Sophie McKenna, Frances Aylward, Xeni Miliara, Rikin J Lau, Camilla Berg Huemer, Sean P Giblin, Kristin K Huse, Mingyang Liang, Lucy Reeves, Max Pearson, Yingqi Xu, Sarah L Rouse, James E Pease, Shiranee Sriskandan, Todd F Kagawa, Jakki Cooney, Stephen Matthews
Annually, over 18 million disease cases and half a million deaths worldwide are estimated to be caused by Group A Streptococcus. ScpA (or C5a peptidase) is a well characterised member of the cell enveleope protease family, which possess a S8 subtilisin-like catalytic domain and a shared multi-domain architecture. ScpA cleaves complement factors C5a and C3a, impairing the function of these critical anaphylatoxins and disrupts complement-mediated innate immunity. Although the of high resolution of structure ScpA is known, the details of how it recognises its substrate are only just emerging...
August 8, 2023: Biochimica et Biophysica Acta. Proteins and Proteomics