Zachary P Billman, Stephen B Kovacs, Bo Wei, Kidong Kang, Ousmane H Cissé, Edward A Miao
UNLABELLED: Gasdermins oligomerize to form pores in the cell membrane, causing programmed lytic cell death called pyroptosis. Mammals encode five gasdermins that can trigger pyroptosis: GSDMA, B, C, D, and E. Caspase and granzyme proteases cleave the linker regions of and activate GSDMB, C, D, and E, but no endogenous activation pathways are yet known for GSDMA. Here, we perform a comprehensive evolutionary analysis of the gasdermin family and focus on the first gene amplification event that gave rise to mammal GSDMA-D by studying GSDMA in non-mammal species including amphibians, reptiles, and birds...
September 28, 2023: bioRxiv