keyword
https://read.qxmd.com/read/33993133/antispasmodics-for-chronic-abdominal-pain-analysis-of-north-american-treatment-options
#21
REVIEW
Darren M Brenner, Brian E Lacy
Chronic abdominal pain is a common gastrointestinal (GI) symptom that characterizes many functional GI disorders/disorders of gut-brain interaction, including irritable bowel syndrome, functional dyspepsia, and centrally mediated abdominal pain syndrome. The symptoms of abdominal pain in these highly prevalent disorders are often treated with antispasmodic agents. Antispasmodic treatment includes a broad range of therapeutic classes with different mechanisms of action, including anticholinergic/antimuscarinic agents (inhibition of GI smooth muscle contraction), calcium channel inhibitors (inhibition of calcium transport into GI smooth muscle), and direct smooth muscle relaxants (inhibition of sodium and calcium transport)...
August 1, 2021: American Journal of Gastroenterology
https://read.qxmd.com/read/33923707/repositioning-trimebutine-maleate-as-a-cancer-treatment-targeting-ovarian-cancer-stem-cells
#22
JOURNAL ARTICLE
Heejin Lee, Oh-Bin Kwon, Jae-Eon Lee, Yong-Hyun Jeon, Dong-Seok Lee, Sang-Hyun Min, Jun-Woo Kim
The overall five-year survival rate for late-stage patients of ovarian cancer is below 29% due to disease recurrence and drug resistance. Cancer stem cells (CSCs) are known as a major contributor to drug resistance and recurrence. Accordingly, therapies targeting ovarian CSCs are needed to overcome the limitations of present treatments. This study evaluated the effect of trimebutine maleate (TM) targeting ovarian CSCs, using A2780-SP cells acquired by a sphere culture of A2780 epithelial ovarian cancer cells...
April 16, 2021: Cells
https://read.qxmd.com/read/33835230/evaluation-of-clinical-outcomes-and-efficacy-of-palonosetron-and-granisetron-in-combination-with-dexamethasone-in-egyptian-patients-receiving-highly-emetogenic-chemotherapy
#23
RANDOMIZED CONTROLLED TRIAL
Mohamed A Mahrous, Gamal A El-Azab, Hisham A Tawfik
BACKGROUND: Chemotherapy-induced nausea and vomiting (CINV) is considered one of the most serious adverse events affecting chemotherapy-receiving cancer patients. It dramatically affects their food intake, nutritional status and more importantly their quality of life. We can observe CINV in highly emetogenic chemotherapy (HEC) such as adriamycin-cyclophosphamide combination (AC) in breast cancer patients and cisplatin-based regimens in other cancer types. This study aimed to evaluate the antiemetic efficacy of palonosetron (PALO) over granisetron (GRA) in combination with dexamethasone for multiple highly emetogenic chemotherapy drugs (HEC), especially in chemotherapy regimens in Egyptian breast cancer patients and cisplatin-based regimens in other diseases...
July 2021: Cancer Chemotherapy and Pharmacology
https://read.qxmd.com/read/33767276/risk-of-qt-prolongation-through-drug-interactions-between-hydroxychloroquine-and-concomitant-drugs-prescribed-in-real-world-practice
#24
JOURNAL ARTICLE
Byung Jin Choi, Yeryung Koo, Tae Young Kim, Wou Young Chung, Yun Jung Jung, Ji Eun Park, Hong-Seok Lim, Bumhee Park, Dukyong Yoon
Hydroxychloroquine has recently received attention as a treatment for COVID-19. However, it may prolong the QTc interval. Furthermore, when hydroxychloroquine is administered concomitantly with other drugs, it can exacerbate the risk of QT prolongation. Nevertheless, the risk of QT prolongation due to drug-drug interactions (DDIs) between hydroxychloroquine and concomitant medications has not yet been identified. To evaluate the risk of QT prolongation due to DDIs between hydroxychloroquine and 118 concurrent drugs frequently used in real-world practice, we analyzed the electrocardiogram results obtained for 447,632 patients and their relevant electronic health records in a tertiary teaching hospital in Korea from 1996 to 2018...
March 25, 2021: Scientific Reports
https://read.qxmd.com/read/33535070/the-trimebutine-effect-on-helicobacter-pylori-related-gastrointestinal-tract-and-brain-disorders-a-hypothesis
#25
REVIEW
Marina Boziki, Nikolaos Grigoriadis, Apostolis Papaefthymiou, Michael Doulberis, Stergios A Polyzos, Emmanuel Gavalas, Georgia Deretzi, Eleni Karafoulidou, Evangelia Kesidou, Charilaos Taloumtzis, Paschalis Theotokis, Electra Sofou, Panagiotis Katsinelos, Elisabeth Vardaka, Ioannis Fludaras, Maria Touloumtzi, Argiro Koukoufiki, Constantina Simeonidou, Christos Liatsos, Jannis Kountouras
The localization of bacterial components and/or metabolites in the central nervous system may elicit neuroinflammation and/or neurodegeneration. Helicobacter pylori (a non-commensal symbiotic gastrointestinal pathogen) infection and its related metabolic syndrome have been implicated in the pathogenesis of gastrointestinal tract and central nervous system disorders, thus medications affecting the nervous system - gastrointestinal tract may shape the potential of Helicobacter pylori infection to trigger these pathologies...
January 31, 2021: Neurochemistry International
https://read.qxmd.com/read/33484186/amelioration-of-the-abnormal-phenotype-of-a-new-l1-syndrome-mouse-mutation-with-l1-mimetics
#26
JOURNAL ARTICLE
Gabriele Loers, Dominik Appel, David Lutz, Ludovica Congiu, Ralf Kleene, Irm Hermans-Borgmeyer, Michael K E Schäfer, Melitta Schachner
L1 syndrome is a rare developmental disorder characterized by hydrocephalus of varying severity, intellectual deficits, spasticity of the legs, and adducted thumbs. Therapy is limited to symptomatic relief. Numerous gene mutations in the L1 cell adhesion molecule (L1CAM, hereafter abbreviated L1) were identified in L1 syndrome patients, and those affecting the extracellular domain of this transmembrane type 1 glycoprotein show the most severe phenotypes. Previously analyzed rodent models of the L1 syndrome focused on L1-deficient animals or mouse mutants with abrogated cell surface expression of L1, making it difficult to test L1 function-triggering mimetic compounds with potential therapeutic value...
February 2021: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/33302063/role-of-ranitidine-in-n-nitrosodimethylamine-formation-during-chloramination-of-competing-micropollutants
#27
JOURNAL ARTICLE
Mingizem Gashaw Seid, Jaeshik Chung, Jaewan Choe, Kangwoo Cho, Seok Won Hong
Ranitidine (RNT) is a widely known precursor of N-nitrosodimethylamine (NDMA) as evinced by the self-catalytic formation of NDMA during chloramination. In the present study, the NDMA formation potentials (NDMA-FP) of 26 micropollutants were assessed, particularly when mixed with RNT. 11 compounds were identified as individual precursors, including trimebutine and cimetidine, which exhibited substantial NDMA-FP, with up to 10% molar yield. In addition, nitrosamines, other than NDMA, namely N-nitrosodiethylamine and N-nitrosomethylamine, were observed from diethylamine-containing precursors, such as metoclopramide...
February 20, 2021: Science of the Total Environment
https://read.qxmd.com/read/33299403/acupuncture-for-adults-with-diarrhea-predominant-irritable-bowel-syndrome-or-functional-diarrhea-a-systematic-review-and-meta-analysis
#28
REVIEW
Jianbo Guo, Xiaoxiao Xing, Jiani Wu, Hui Zhang, Yongen Yun, Zongshi Qin, Qingyong He
Obj ective. To evaluate the clinical effectiveness and safety of acupuncture therapy in the treatment of diarrhea-predominant irritable bowel syndrome (IBS-D) or functional diarrhea (FD) in adults. Method. Five electronic databases-PubMed, EMBASE, CNKI, VIP, and Wanfang-were searched, respectively, until June 8, 2020. The literature of clinical randomized controlled trials of acupuncture for the treatment of IBS-D or FD in adults were collected. Meta-analysis was conducted by Using Stata 16.0 software, the quality of the included studies was assessed by the RevMan ROB summary and graph, and the results were graded by GRADE...
2020: Neural Plasticity
https://read.qxmd.com/read/32650518/trimebutine-maleate-monotherapy-for-functional-dyspepsia-a-multicenter-randomized-double-blind-placebo-controlled-prospective-trial
#29
JOURNAL ARTICLE
Jannis Kountouras, Emmanuel Gavalas, Apostolis Papaefthymiou, Ioannis Tsechelidis, Stergios A Polyzos, Serhat Bor, Mircea Diculescu, Κhaled Jadallah, Mazurek Tadeusz, Tarkan Karakan, Αnna Bochenek, Jerzy Rozciecha, Piotr Dabrowski, Zeno Sparchez, Orhan Sezgin, Macit Gülten, Niazy Abu Farsakh, Michael Doulberis
Background and Objectives: Functional dyspepsia (FD) is one of the most common functional gastrointestinal disorders; it has a great impact on patient quality of life and is difficult to treat satisfactorily. This study evaluates the efficacy and safety of trimebutine maleate (TM) in patients with FD. Materials and Methods : Α multicenter, randomized, double-blind, placebo controlled, prospective study was conducted, including 211 patients with FD. Participants were randomized to receive TM 300 mg twice per day (BID, 108 patients) or placebo BID (103 patients) for 4 weeks...
July 8, 2020: Medicina
https://read.qxmd.com/read/31617696/trimebutine-a-state-of-the-art-review
#30
REVIEW
Beatrice Salvioli
Trimebutine maleate has been used extensively, since the late 1960's, for the treatment of functional gastrointestinal disorders, including irritable bowel syndrome (IBS). It is usually linked to the antispasmodic class of agents, but its properties make trimebutine an unmatched and multi-tasking compound. The efficacy on relieving abdominal pain has been demonstrated in various clinical studies with different protocols of treatment. The main effect was first believed to be merely due to its antispastic activity, but further evidences expanded the acknowledgement of a broader impact on the gastrointestinal tract...
September 2019: Minerva Gastroenterologica e Dietologica
https://read.qxmd.com/read/31614275/green-conventional-and-first-order-derivative-fluorimetry-methods-for-determination-of-trimebutine-and-its-degradation-product-eudesmic-acid-emphasis-on-the-solvent-and-ph-effects-on-their-emission-spectral-properties
#31
JOURNAL ARTICLE
Rania El-Shaheny, Fathalla Belal
In this report, the fluorescence properties of the antimuscarinic drug trimebutine maleate (TRB) were fully studied and characterized. TRB exhibited intrinsic fluorescence that is greatly dependent on the local environmental factors including the solvent nature and the pH. Yet, its fluorescence was not significantly influenced by the existence of some surface active agents and polymer. The outcomes of this investigation verified that TRB fluorescence emission is intense in ethanol: 1.0 M aqueous acetic acid (9:1, v/v) with emission maxima at 357 nm and excitation maxima at 270 nm...
February 5, 2020: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://read.qxmd.com/read/31040633/gastroesophageal-reflux-disease-irritable-bowel-syndrome-and-functional-dyspepsia-as-overlapping-conditions-focus-on-effect-of-trimebutine
#32
JOURNAL ARTICLE
Jannis Kountouras, Michael Doulberis, Apostolis Papaefthimiou, Stergios A Polyzos
No abstract text is available yet for this article.
2019: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://read.qxmd.com/read/30723513/clinical-effects-and-safety-of-tongxieyaofang-on-diarrhea-predominant-irritable-bowel-syndrome-a-meta-analysis-of-randomized-trails
#33
REVIEW
Yuhong Zhou, Shutang Han, Yamin He
Background. Tongxieyaofang (TXYF), a prescription originated from traditional Chinese medicine (TCM), has been widely used on treating Diarrhea Predominant Irritable Bowel Syndrome (IBS-D). The purpose of this meta-analysis was to investigate whether TXYF was effective and safe for IBS-D. Methods. We searched seven electronic databases including CENTRAL, MEDLINE, PubMed, CNKI, VIP, CBM, and Wanfang Data up to 26 July 2017. Randomized controlled trails (RCTs) were eligible, regardless of blinding. Risk of bias of included trials was evaluated according to the Cochrane Handbook...
2019: Evidence-based Complementary and Alternative Medicine: ECAM
https://read.qxmd.com/read/30484889/trimebutine-maleate-relaxes-the-isolated-rat-thoracic-aorta-the-role-of-nitric-oxide-and-l-type-calcium-channels
#34
JOURNAL ARTICLE
Mine Kadioglu, Yesim Kaya Yasar, Elif Nur Barut, Seckin Engin
Trimebutine maleate (TMB), a widely prescribed drug for functional gastrointestinal disorders, has been reported to regulate smooth muscle contractility by modulating multiple ion channel activities in the gastrointestinal tract. However, its action on isolated aorta has not yet been reported. The aim of the present study was to evaluate in vitro vasorelaxant properties and the underlying pharmacological mechanisms of TMB in isolated rat thoracic aortic rings. Vascular activity experiments were performed on thoracic aorta isolated from Sprague-Dawley rats in vitro, including endothelium-intact and endothelium-denuded aortic rings...
April 2019: Clinical and Experimental Pharmacology & Physiology
https://read.qxmd.com/read/30114898/the-effect-of-trimebutine-on-the-overlap-syndrome-model-of-guinea-pigs
#35
JOURNAL ARTICLE
Zahid Hussain, Da Hyun Jung, Young Ju Lee, Hyojin Park
Background/Aims: Functional dyspepsia (FD) and irritable bowel syndrome (IBS) are common gastrointestinal (GI) disorders and these patients frequently overlap. Trimebutine has been known to be effective in controlling FD co-existing diarrhea-dominant IBS, however its effect on overlap syndrome (OS) patients has not been reported. Therefore, we investigated the effect of trimebutine on the model of OS in guinea pigs. Methods: Male guinea pigs were used to evaluate the effects of trimebutine in corticotropin-releasing factor (CRF) induced OS model...
October 1, 2018: Journal of Neurogastroenterology and Motility
https://read.qxmd.com/read/29977208/trimebutine-promotes-glioma-cell-apoptosis-as-a-potential-anti-tumor-agent
#36
JOURNAL ARTICLE
Yi-Pu Fan, Pei Liu, Wei-Kang Xue, Wei-Jiang Zhao, Hong-Chao Pan
Gliomas are the most common primary brain tumors with a usually fatal malignancy. They are associated with a poor prognosis although multiple therapeutic options have been available. Trimebutine is one of the prokinetic agents and it has been mainly used for treatment of disorders of the gastrointestinal (GI) tract such as irritable bowel syndrome. However, its effects on glioma cells remain unknown. Here, we used various concentrations of trimebutine to treat SHG44, U251, and U-87 MG human glioma/glioblastoma cells...
2018: Frontiers in Pharmacology
https://read.qxmd.com/read/28966237/inhibitory-effects-of-gastrointestinal-drugs-on-cyp-activities-in-human-liver-microsomes
#37
JOURNAL ARTICLE
Mariko Iwase, Yuki Nishimura, Norimitsu Kurata, Hokuto Namba, Takahito Hirai, Yuji Kiuchi
OTC drugs have an important role in self-medication. However, the pharmacokinetic properties of some OTC drugs have not been fully investigated and reports concerning their drug interactions are insufficient. Several gastrointestinal drugs are available as OTC drugs. Because of their pharmacological properties, these drugs are often used concomitantly with other drugs. Therefore, it is important to predict the possible drug interactions among these drugs. In the current study, we investigated the inhibitory effects of five gastrointestinal drugs, namely loperamide, oxethazaine, papaverine, pirenzepine, and trimebutine, on CYP activities in human liver microsomes...
2017: Biological & Pharmaceutical Bulletin
https://read.qxmd.com/read/28714852/trimebutine-a-small-molecule-mimetic-agonist-of-adhesion-molecule-l1-contributes-to-functional-recovery-after-spinal-cord-injury-in-mice
#38
JOURNAL ARTICLE
Junping Xu, Chengliang Hu, Qiong Jiang, Hongchao Pan, Huifan Shen, Melitta Schachner
Curing spinal cord injury (SCI) in mammals is a daunting task because of the lack of permissive mechanisms and strong inhibitory responses at and around the lesion. The neural cell adhesion molecule L1CAM (L1) has been shown to favor axonal regrowth and enhance neuronal survival and synaptic plasticity but delivery of full-length L1 or its extracellular domain could encounter difficulties in translation to therapy in humans. We have, therefore, identified several small organic compounds that bind to L1 and stimulate neuronal survival, neuronal migration and neurite outgrowth in an L1-dependent manner...
September 1, 2017: Disease Models & Mechanisms
https://read.qxmd.com/read/28651565/prokinetics-for-the-treatment-of-functional-dyspepsia-bayesian-network-meta-analysis
#39
JOURNAL ARTICLE
Young Joo Yang, Chang Seok Bang, Gwang Ho Baik, Tae Young Park, Suk Pyo Shin, Ki Tae Suk, Dong Joon Kim
BACKGROUND: Controversies persist regarding the effect of prokinetics for the treatment of functional dyspepsia (FD). This study aimed to assess the comparative efficacy of prokinetic agents for the treatment of FD. METHODS: Randomized controlled trials (RCTs) of prokinetics for the treatment of FD were identified from core databases. Symptom response rates were extracted and analyzed using odds ratios (ORs). A Bayesian network meta-analysis was performed using the Markov chain Monte Carlo method in WinBUGS and NetMetaXL...
June 26, 2017: BMC Gastroenterology
https://read.qxmd.com/read/28236087/gastrointestinal-pharmacology
#40
REVIEW
Miguel Saps, Adrian Miranda
There is little evidence for most of the medications currently used to treat functional abdominal pain disorders (FAPDs) in children. Not only are there very few clinical trials, but also most have significant variability in the methods used and outcomes measured. Thus, the decision on the most appropriate pharmacological treatment is frequently based on adult studies or empirical data. In children, peppermint oil, trimebutine, and drotaverine have shown significant benefit compared with placebo, each of them in a single randomized clinical trial...
2017: Handbook of Experimental Pharmacology
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