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plaque characterization

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https://www.readbyqxmd.com/read/29771915/inactivation-of-bpsl1039-1040-atp-binding-cassette-transporter-reduces-intracellular-survival-in-macrophages-biofilm-formation-and-virulence-in-the-murine-model-of-burkholderia-pseudomallei-infection
#1
Peechanika Pinweha, Pornpan Pumirat, Jon Cuccui, Niramol Jitprasutwit, Veerachat Muangsombut, Varintip Srinon, Usa Boonyuen, Parameth Thiennimitr, Paiboon Vattanaviboon, Felipe Cia, Sam Willcocks, Gregory J Bancroft, Brendan W Wren, Sunee Korbsrisate
Burkholderia pseudomallei, a gram-negative intracellular bacillus, is the causative agent of a tropical infectious disease called melioidosis. Bacterial ATP-binding cassette (ABC) transporters import and export a variety of molecules across bacterial cell membranes. At present, their significance in B. pseudomallei pathogenesis is poorly understood. We report here characterization of the BPSL1039-1040 ABC transporter. B. pseudomallei cultured in M9 medium supplemented with nitrate, demonstrated that BPSL1039-1040 is involved in nitrate transport for B...
2018: PloS One
https://www.readbyqxmd.com/read/29771632/immunohistochemical-expression-hif1%C3%AE-in-chronic-plaque-psoriasis-an-association-with-angiogenesis-and-proliferation
#2
Asmaa Gaber Abdou, Azza G A Farag, Moustafa Hammam, Doha Maher Taie, Reem Ahmed Abdelaziz
Psoriasis is characterized by excessive cell proliferation, angiogenesis, and regions of hypoxia. Hypoxia stimulates production of hypoxia inducible factors (HIFs) such as HIF1α. The aim of the present study is to investigate the possible role of HIF1α in pathogenesis of psoriasis and to correlate its expression with angiogenesis and proliferation in involved and uninvolved skin in patients with plaque psoriasis using CD34 and Ki-67. The current study was performed on 40 skin specimens of patients presented with chronic plaque psoriasis both involved and uninvolved together with 40 specimens from age- and sex-matched healthy volunteers as a control group...
May 17, 2018: Journal of Immunoassay & Immunochemistry
https://www.readbyqxmd.com/read/29765969/cutaneous-leishmaniasis-a-case-involving-the-scalp-clinical-and-videodermoscopic-findings
#3
Carlos Daniel Sánchez Cárdenas, Yolanda Judith Álvarez Luna, Yesenia Bello Hernández, Daniel Asz Sigall, Roberto Arenas Guzmán
Cutaneous leishmaniasis (CL) is a worldwide infectious disease caused by flagellate protozoa of the genus Leishmania . In America, the species most commonly responsible for CL are L. mexicana and L. brasiliensis . Usually, in America, it is transmitted by sand flies mainly of the genus Lutzomyia and Psychodopygus . CL most commonly affects exposed areas and is characterized by an erythematous infiltrated and ulcerated papular or nodular lesion. We report a 28-year-old male, with a 6-month history and a previous trip to the forest in the south of Mexico...
April 2018: Skin Appendage Disorders
https://www.readbyqxmd.com/read/29765908/the-subgingival-microbiome-of-periodontal-pockets-with-different-probing-depths-in-chronic-and-aggressive-periodontitis-a-pilot-study
#4
Meng Shi, Yiping Wei, Wenjie Hu, Yong Nie, Xiaolei Wu, Ruifang Lu
Periodontitis is a kind of infectious disease initiated by colonization of subgingival periodontal pathogens, which cause destruction of tooth-supporting tissues, and is a predominant threat to oral health as the most common cause of loss of teeth. The aim of this pilot study was to characterize the subgingival bacterial biodiversity of periodontal pockets with different probing depths in patients with different forms of periodontitis. Twenty-one subgingival plaque samples were collected from three patients with chronic periodontitis (ChP), three patients with aggressive periodontitis (AgP) and three periodontally healthy subjects (PH)...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29760458/hyperglycemia-does-not-affect-tissue-repair-responses-in-shear-stress-induced-atherosclerotic-plaques-in-apoe-mice
#5
Sabrina Hsiung, Anki Knutsson, Jenifer Vallejo, Pontus Dunér, Suvi E Heinonen, Ann-Cathrine Jönsson-Rylander, Eva Bengtsson, Jan Nilsson, Anna Hultgårdh-Nilsson
The mechanisms responsible for macrovascular complications in diabetes remain to be fully understood. Recent studies have identified impaired vascular repair as a possible cause of plaque vulnerability in diabetes. This notion is supported by observations of a reduced content of fibrous proteins and smooth muscle cell mitogens in carotid endarterectomy from diabetic patients along with findings of decreased circulating levels of endothelial progenitor cells. In the present study we used a diabetic mouse model to characterize how hyperglycemia affects arterial repair responses...
May 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29758300/alzheimer-s-disease-and-the-autophagic-lysosomal-system
#6
REVIEW
Kyung Min Chung, Nancy Hernández, Andrew Sproul, Wai Haung Yu
Age-related neurodegenerative diseases are of critical concern to the general population and research/medical community due to their health impact and socioeconomic consequences. A feature of most, if not all, neurodegenerative disorders is the presence of proteinopathies, in which misfolded or conformationally altered proteins drive disease progression and are often used as a primary neuropathological marker of disease. In particular, Alzheimer's disease (AD) is characterized by abnormal accumulation of protein aggregates, primarily extracellular plaques composed of the Aβ peptide and intracellular tangles comprised of the tau protein, both of which may indicate a primary defect in protein clearance...
May 11, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29758264/anti-il17-treatment-ameliorates-down-syndrome-phenotypes-in-mice
#7
Noemí Rueda, Verónica Vidal, Susana García-Cerro, Josep Oriol Narcís, María Llorens-Martín, Andrea Corrales, Sara Lantigua, Marcos Iglesias, Jesús Merino, Ramón Merino, Carmen Martínez-Cué
Down syndrome (DS) is characterized by structural and functional anomalies that are present prenatally and that lead to intellectual disabilities. Later in life, the cognitive abilities of DS individuals progressively deteriorate due to the development of Alzheimer's disease (AD)-associated neuropathology (i.e., β-amyloid (Aβ) plaques, neurofibrillary tangles (NFTs), neurodegeneration, synaptic pathology, neuroinflammation and increased oxidative stress). Increasing evidence has shown that among these pathological processes, neuroinflammation plays a predominant role in AD etiopathology...
May 11, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29755842/lipopolysaccharide-endotoxemia-induces-amyloid-%C3%AE-and-p-tau-formation-in-the-rat-brain
#8
Li-Ming Wang, Qi Wu, Ryan A Kirk, Kevin P Horn, Ahmed H Ebada Salem, John M Hoffman, Jeffrey T Yap, Joshua A Sonnen, Rheal A Towner, Fernando A Bozza, Rosana S Rodrigues, Kathryn A Morton
Amyloid beta (Aβ) plaques are not specific to Alzheimer's disease and occur with aging and neurodegenerative disorders. Soluble brain Aβ may be neuroprotective and increases in response to neuroinflammation. Sepsis is associated with neurocognitive compromise. The objective was to determine, in a rat endotoxemia model of sepsis, whether neuroinflammation and soluble Aβ production are associated with Aβ plaque and hyperphosphorylated tau deposition in the brain. Male Sprague Dawley rats received a single intraperitoneal injection of 10 mg/kg of lipopolysaccharide endotoxin (LPS)...
2018: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29755512/proton-pump-inhibitors-and-dementia-physiopathological-mechanisms-and-clinical-consequences
#9
REVIEW
Gloria Ortiz-Guerrero, Diana Amador-Muñoz, Carlos Alberto Calderón-Ospina, Daniel López-Fuentes, Mauricio Orlando Nava Mesa
Alzheimer's disease (AD) is the most common type of dementia, mainly encompassing cognitive decline in subjects aged ≥65 years. Further, AD is characterized by selective synaptic and neuronal degeneration, vascular dysfunction, and two histopathological features: extracellular amyloid plaques composed of amyloid beta peptide (A β ) and neurofibrillary tangles formed by hyperphosphorylated tau protein. Dementia and AD are chronic neurodegenerative conditions with a complex physiopathology involving both genetic and environmental factors...
2018: Neural Plasticity
https://www.readbyqxmd.com/read/29754908/an-operational-definition-of-shats-systemic-hemodynamic-atherosclerotic-syndrome-role-of-arterial-stiffness-and-blood-pressure-variability-in-elderly-hypertensive-subjects
#10
Angelo Scuteri, Valentina Rovella, Danilo Alunni Fegatelli, Manfredi Tesauro, Marco Gabriele, Nicola Di Daniele
BACKGROUND: CV risk exponentially increases as the number of damaged organs increases The Systemic Hemodynamic Atherosclerotic Syndrome (SHATS) represents a novel conceptualization of the CV continuum focusing on simultaneous multi-organ alteration. This is the first study operationally defining SHATS and aimed at identifying its determinants. METHODS: Left Ventricular Hypertrophy (echocardiography), Common Carotid Artery plaque and increased thickness (ultrasound), and Chronic Kidney Disease (estimated Glomerular Filtration Rate) indexed selective target organ damage...
July 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29754526/recurrent-pityriasis-rubra-pilaris-a-case-report
#11
Megan E MacGillivray, Loretta Fiorillo
Pityriasis rubra pilaris (PRP) is an uncommon papulosquamous dermatosis characterized by follicular, erythematous, hyperkeratotic papules coalescing to salmon-coloured plaques with islands of sparing. The disease tends to be self-limited and resolves spontaneously after a few years. In some cases, the disease is persistent. However, recurrence of this disease has rarely been described. An 8-year-old male was diagnosed with type III (classic juvenile) PRP. He was treated with acitretin, and his skin was clear after 6 months...
May 1, 2018: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29753872/molecular-and-biological-characterization-of-the-human-bovine-rotavirus-based-reassortant-rotavirus
#12
Ehsan Zafari, Hoorieh Soleimanjahi, Ashraf Mohammadi, Ali Teimoori, Homayon Mahravani
Rotaviruses (RV) are the leading cause of acute infantile gastroenteritis, associated with elevated mortality in low-income countries. Morbidity and mortality, length and rates of hospitalization due to RV gastroenteritis are dropping. Improving the quality of newborns life is an ongoing challenge for health-care providers. In this study, homemade reassortant human-bovine rotavirus was developed and biological activity and molecular characterization of candidate vaccine were evaluated for the vaccine stability...
May 10, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29751505/passive-a%C3%AE-immunotherapy-current-achievements-and-future-perspectives
#13
REVIEW
Stephan Schilling, Jens-Ulrich Rahfeld, Inge Lues, Cynthia A Lemere
Passive immunotherapy has emerged as a very promising approach for the treatment of Alzheimer’s disease and other neurodegenerative disorders, which are characterized by the misfolding and deposition of amyloid peptides. On the basis of the amyloid hypothesis, the majority of antibodies in clinical development are directed against amyloid β (Aβ), the primary amyloid component in extracellular plaques. This review focuses on the current status of Aβ antibodies in clinical development, including their characteristics and challenges that came up in clinical trials with these new biological entities (NBEs)...
May 3, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29745818/novel-insights-into-renal-mineralization-and-stone-formation-through-advanced-imaging-modalities
#14
Scott V Wiener, Ling Chen, Alex R Shimotake, Misun Kang, Marshall L Stoller, Sunita P Ho
Purpose/Aim: The most common kidney stone composed of calcium oxalate forms on interstitial calcium phosphate mineral known as a Randall's plaque (RP). Due to limited information about events leading to the initial deposition of nanometer size interstitial calcium phosphate pre-clusters, there continues to be a debate on the initial site of calcium phosphate deposition and factors leading to stone formation. MATERIALS AND METHODS: High-resolution X-ray micro-computed tomography (CT), and light and electron microscopy techniques were used to characterize human renal pyramids and five representative kidney stones with identifiable stems...
December 2018: Connective Tissue Research
https://www.readbyqxmd.com/read/29744913/cartilage-hair-hypoplasia-with-cutaneous-lymphomatoid-granulomatosis
#15
D Sathishkumar, J E Gach, M Ogboli, M Desai, T Cole, W Högler, J Motwani, A Norton, B Morland, I Colmenero
Cartilage-hair hypoplasia (CHH) is an autosomal recessive chondrodysplasia characterized by short-stature, sparse hair and impaired cellular immunity. We describe a young girl who was diagnosed with CHH based on the findings of recurrent infections, short stature with metaphyseal chondrodysplasia, and a confirmed bi-allelic RMRP gene mutation. At 13 years, the patient developed an Epstein-Barr virus (EBV)-driven lymphoproliferative disorder involving the lung, which responded partially to chemotherapy. Simultaneously, she developed multiple indurated plaques involving her face, which had histological findings of granulomatous inflammation and EBV-associated low-grade lymphomatoid granulomatosis...
May 10, 2018: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/29744850/incorporation-of-an-azobenzene-%C3%AE-turn-peptidomimetic-into-amyloid-%C3%AE-to-probe-potential-structural-motifs-leading-to-%C3%AE-sheet-self-assembly
#16
Todd M Doran, Bradley L Nilsson
Alzheimer's disease (AD) is characterized by chronic neurodegeneration and the insidious accumulation of senile plaques comprised of the amyloid-β (Aβ) peptide. An important goal in AD research is to characterize the structural basis for how Aβ aggregates exert their noxious effects on neurons. We describe herein synthetic steps to incorporate a light-controlled β-turn mimetic, 3-(3-aminomethylphenylazo)-phenylacetic acid (AMPP), into the backbone of a putative turn region within Aβ. AMPP adopts a rigid β-hairpin turn when azobenzene is in the cis conformation, and can adopt an extended "β-arc" turn in the trans-azobenzene conformation...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29741759/anionic-nanoliposomes-reduced-atherosclerosis-progression-in-low-density-lipoprotein-receptor-ldlr-deficient-mice-fed-a-high-fat-diet
#17
Smriti M Krishna, Joseph V Moxon, Roby J Jose, Jiaze Li, Amirhossein Sahebkar, Mahmoud R Jaafari, Mahdi Hatamipour, Dawie Liu, Jonathan Golledge
Atherosclerosis is a systemic disease characterized by the deposition of cholesterol and inflammatory cells within the arterial wall. Removal of cholesterol from the vessel wall may have an impact on the size and composition of atherosclerotic lesions. Anionic phospholipids or liposome vesicles composed of a lipid bilayer such as nanoliposomes have been suggested as treatments for dyslipidemia. In this study, we investigated the effect of anionic nanoliposomes on atherosclerosis in a mouse model. Low-density lipoprotein receptor knockout mice (Ldlr-/- ) were fed with an atherosclerosis promoting high fat and cholesterol (HFC) diet for 12 weeks...
May 9, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29737271/human-and-equine-infection-with-alphaviruses-and-flaviviruses-in-panam%C3%A3-during-2010-a-cross-sectional-study-of-household-contacts-during-an-encephalitis-outbreak
#18
Jean-Paul Carrera, Karoun H Bagamian, Amelia P Travassos da Rosa, Eryu Wang, Davis Beltran, Nathan D Gundaker, Blas Armien, Gianfranco Arroyo, Néstor Sosa, Juan Miguel Pascale, Anayansi Valderrama, Robert B Tesh, Amy Y Vittor, Scott C Weaver
Members of the genera Alphavirus (family Togaviridae ) and Flavivirus (family Flaviridae ) are important zoonotic human and equine etiologic agents of neurologic diseases in the New World. In 2010, an outbreak of Madariaga virus (MADV; formerly eastern equine encephalitis virus) and Venezuelan equine encephalitis virus (VEEV) infections was reported in eastern Panamá. We further characterized the epidemiology of the outbreak by studying household contacts of confirmed human cases and equine cases with neurological disease signs...
May 7, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29736839/stricturing-and-fistulizing-crohn-s-disease-is-associated-with-anti-tumor-necrosis-factor-induced-psoriasis-in-patients-with-inflammatory-bowel-disease
#19
Adam V Weizman, Robyn Sharma, N M Afzal, Wei Xu, Scott Walsh, Joanne M Stempak, Geoffrey C Nguyen, Ken Croitoru, A Hillary Steinhart, Mark S Silverberg
BACKGROUND: Paradoxical development of psoriasis in patients on anti-TNF agents has been increasingly reported. AIM: The aim was to characterize the prevalence and clinical characteristics of anti-TNF-associated psoriasis in a large cohort of inflammatory bowel disease patients. METHODS: Medical records of patients with Crohn's disease or ulcerative colitis treated with anti-TNF therapy at a single, tertiary IBD center were identified between 2004 and 2016...
May 8, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29736391/the-effects-of-antimicrobial-peptide-nal-p-113-on-inhibiting-periodontal-pathogens-and-improving-periodontal-status
#20
Hongyan Wang, Lisi Ai, Yu Zhang, Jyawei Cheng, Huiyuan Yu, Chen Li, Dongmei Zhang, Yaping Pan, Li Lin
Periodontal disease consists of chronic gingival inflammation characterized by both degradation of the periodontal connective tissue and alveolar bone loss. Drug therapy is used as an auxiliary treatment method in severe chronic periodontitis, aggressive periodontitis, and periodontitis-associated systemic disease. Nal-P-113, a modified antimicrobial peptide, specifically replaces the histidine residues of P-113 with the bulky amino acid β -naphthylalanine, and our previous studies have verified that this novel peptide is not toxic to the human body within a certain concentration range...
2018: BioMed Research International
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