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Inmune reconstitution

Anju Seth, Sudha Deepa, Renu Dutta, Jagdish Chandra
BACKGROUND: Children with HIV (CLHIV) respond poorly to primary immunization with measles vaccine and those responding tend to lose protective titer of antibodies by 2-3 years old. Revaccinating CLHIV after immune reconstitution with antiretroviral therapy (ART) may result in good seroconversion, thereby conferring them protection from measles. The objective was to study prevalence of measles antibodies in CLHIV receiving ART before and after immunization with MMR vaccine. METHODS: CLHIV in the age 5-18 years receiving ART for >6 months and with CD 4 count >15% were included in this prospective study...
January 2016: Pediatric Infectious Disease Journal
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