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https://www.readbyqxmd.com/read/28933180/-viral-hepatitis-c-and-organ-transplantation
#1
Libuše Husová, Vladimír Mejzlík
At the Centre for Cardiovascular and Transplantation Surgery, Brno (CKTCH), a total of 638 liver transplantations were performed from the beginning of the transplantation programme on 2/2 1983 to 1/1 2017. Of the overall number of 638 transplantations indicated based on cirrhosis with chronic hepatitis C (HCV), 68 patients (11 %) underwent liver transplantation. Patients with HCV diagnosis were treated both while on the waiting list and after liver transplantation (LT). There was interferon as well as interferon-free therapy used during the treatment...
2017: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/28932298/expression-of-hnrnpk-claudin-4-in-hcv-induced-early-hcc-and-adjacent-liver-tissue
#2
Olfat Hammam, Mona Magdy, Amgad Anas, Ali Abdel Rahim, Mohamed Heedaya, Ahmed Helmy
BACKGROUND: HCC in Egypt usually occurs in HCV cirrhotic livers with poor prognosis due to late diagnosis. High hnRNPK & low Claudin-4 profiles indicate Epithelial Mesenchymal Transition (EMT), malignant transformation and high-grade tumours. AIM: We studied the immunohistochemical expression of hnRNPK and Claudin-4 in HCV induced early HCC (eHCC) and adjacent liver tissue in Egyptian patients to improve eHCC detection in cirrhotic livers with better curative therapy options...
August 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28931062/factors-associated-with-hepatitis-c-prevalence-differ-by-the-stage-of-liver-fibrosis-a-cross-sectional-study-in-the-general-population-in-poland-2012-2016
#3
Magdalena Rosińska, Natalia Parda, Agnieszka Kołakowska, Paulina Godzik, Karolina Zakrzewska, Kazimierz Madaliński, Andrzej Zieliński, Anna Boguradzka, Rafał Gierczyński, Małgorzata Stępień
BACKGROUND & AIMS: There is a considerable burden of hepatitis C in Europe related to the lack of prompt diagnosis. We aimed to estimate the prevalence and related risk factors of HCV infections by the stages of liver fibrosis, using non-invasive methods, to understand testing needs in Poland. METHODS: A cross-sectional study was conducted in 2012-2016 adopting a stratified random sampling of primary health care units followed by systematic sampling of patients within each unit...
2017: PloS One
https://www.readbyqxmd.com/read/28927831/-beyond-the-willing-the-waiting-the-role-of-peer-based-approaches-in-hepatitis-c-diagnosis-treatment
#4
Charles Henderson, Annie Madden, Jenny Kelsall
This commentary seeks to examine the role, value and importance of peer-based programmatic approaches for ensuring the effective roll-out of the new hepatitis C (HCV) treatments among those most affected - that is, people who inject drugs (PWID). The authors examine recent approaches to HCV treatment in Australia including the provision of universal access to the new DAA regimens regardless of acquisition, genotype or severity of disease. These approaches are contextualised within wider global strategies to support HCV elimination as a public health threat by 2030 (WHO, 2016)...
September 15, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28926326/prevalence-of-hepatitis-a-virus-antibody-in-portuguese-travelers-a-new-paradigm
#5
Sónia Rocha, Sandra Tejo, Eugénia Ferreira, Luís Trindade, Eduardo Rabadão, Nuno Marques, José Saraiva da Cunha
INTRODUCTION: In Portugal, the prevalence of hepatitis A virus infection has decreased in the past decades, especially in young adults. The aim of this study was to detect the prevalence of antibody to hepatitis A virus in a population observed in our Travel Clinic. MATERIAL AND METHODS: Antibodies against hepatitis A, hepatitis B, hepatitis C and human immunodeficiency virus were tested using standard enzyme immunoassay in patients older than 18. The exclusion criteria were: prior vaccination for hepatitis A virus, previous diagnosis of infection with hepatitis B virus, hepatitis C virus and/or human immunodeficiency virus, foreign travelers and long-term expatriates...
August 31, 2017: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28924527/hepatitis-c-screening-the-downstream-dissemination-of-evolving-guidelines-in-a-resident-continuity-clinic
#6
Kamraan Madhani, Ali Aamar, David Chia
Background In 2012, the Centers for Disease Control and Prevention (CDC) published guidelines supporting one-time screening for hepatitis C (HCV) in all persons born between 1945 and 1965. It is estimated that 75% of adults infected with HCV fall within this cohort. Furthermore, it is projected that this preventative health intervention would lead to the diagnosis of 800,000 unknown cases and the prevention of 120,000 deaths. Objectives The primary objectives are to measure adherence to HCV screening in a continuity practice staffed by internal medicine residents and attending physicians and to measure the effect of educational interventions to enhance HCV screening...
July 7, 2017: Curēus
https://www.readbyqxmd.com/read/28924485/hypogonadotropic-hypogonadism-in-human-immunodeficiency-virus-infected-men-uncommonly-low-testosterone-levels
#7
Ana Coelho Gomes, José Maria Aragüés, Sílvia Guerra, Joana Fernandes, Mário Rui Mascarenhas
Hypogonadotropic hypogonadism (HH) is common and occurs prematurely in HIV-infected men. However, HH with very low testosterone has not been described. Three men with normal pubertal development and HIV1 diagnosis at the ages of 22, 34 and 35 years. All complained of decreased libido, anejaculation and erectile dysfunction thirteen years, six months and one year after HIV diagnosis, respectively. Two had depressive syndrome and two were treated with antiretroviral therapy. Laboratory tests revealed isolated HH in all...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/28914118/universal-opt-out-screening-for-hepatitis-c-virus-hcv-within-correctional-facilities-is-an-effective-intervention-to-improve-public-health
#8
Meghan D Morris, Brandon Brown, Scott A Allen
Purpose Worldwide efforts to identify individuals infected with the hepatitis C virus (HCV) focus almost exclusively on community healthcare systems, thereby failing to reach high-risk populations and those with poor access to primary care. In the USA, community-based HCV testing policies and guidelines overlook correctional facilities, where HCV rates are believed to be as high as 40 percent. This is a missed opportunity: more than ten million Americans move through correctional facilities each year. Herein, the purpose of this paper is to examine HCV testing practices in the US correctional system, California and describe how universal opt-out HCV testing could expand early HCV detection, improve public health in correctional facilities and communities, and prove cost-effective over time...
September 11, 2017: International Journal of Prisoner Health
https://www.readbyqxmd.com/read/28903508/effect-of-paritaprevir-ritonavir-ombitasvir-dasabuvir-and-ledipasvir-sofosbuvir-regimens-on-survival-compared-with-untreated-hepatitis-c-virus-infected-persons-results-from-erchives
#9
Adeel Ajwad Butt, Peng Yan, Tracey G Simon, Abdul-Badi Abou-Samra
Background: Interferon-based regimens are associated with a substantial survival benefit for persons infected with hepatitis C virus (HCV). Survival data with direct-acting antiviral agents are not available. We conducted this study to quantify the effect of paritaprevir/ritonavir, ombitasvir, dasabuvir (PrOD) and ledipasvir/sofosbuvir (LDV/SOF) regimens upon mortality. Methods: In the Electronically Retrieved Cohort of HCV Infected Veterans (ERCHIVES), a well-established national cohort of HCV-infected Veterans, we identified HCV-infected persons initiated on PrOD or LDV/SOF, excluding those with human immunodeficiency virus, hepatitis B surface antigen positivity, hepatocellular carcinoma, or missing HCV RNA or FIB-4 scores...
September 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28894901/imaging-features-of-microvascular-invasion-in-hepatocellular-carcinoma-developed-after-direct-acting-antiviral-therapy-in-hcv-related-cirrhosis
#10
Matteo Renzulli, Federica Buonfiglioli, Fabio Conti, Stefano Brocchi, Ilaria Serio, Francesco Giuseppe Foschi, Paolo Caraceni, Giuseppe Mazzella, Gabriella Verucchi, Rita Golfieri, Pietro Andreone, Stefano Brillanti
OBJECTIVES: To evaluate imaging features of microvascular invasion (MVI) in hepatocellular carcinoma (HCC) developed after direct-acting antiviral (DAA) therapy in HCV-related cirrhosis. METHODS: Retrospective cohort study on 344 consecutive patients with HCV-related cirrhosis treated with DAA and followed for 48-74 weeks. Using established imaging criteria for MVI, HCC features were analysed and compared with those in nodules not occurring after DAA. RESULTS: After DAA, HCC developed in 29 patients (single nodule, 18 and multinodular, 11)...
September 11, 2017: European Radiology
https://www.readbyqxmd.com/read/28884440/disappearance-of-multiple-hyperechoic-liver-nodules-in-sporadic-porphyria-cutanea-tarda-after-treatment-with-ledipasvir-sofosbuvir-for-hepatitis-c
#11
Kazuhide Takata, Satoshi Shakado, Keiko Sakamoto, Hiromi Fukuda, Ryo Yamauchi, Sho Fukuda, Hideo Kunimoto, Kaoru Umeda, Takashi Tanaka, Keiji Yokoyama, Daisuke Morihara, Yasuaki Takeyama, Makoto Irie, Shotaro Sakisaka
Ultrasonography in a 60-year-old man with chronic hepatitis C (CHC) demonstrated multiple hyperechoic nodules. Radiological investigations did not reveal any signs of malignancy. However, magnetic resonance chemical shift imaging showed multiple focal fatty changes in the liver. Urinary levels of uroporphyrin and coproporphyrin were elevated, and we made a diagnosis of porphyria cutanea tarda. Direct-acting antivirals, ledipasvir/sofosbuvir, were initiated for CHC, which led to sustained viral response, resolution of the liver nodules, and normalization of urinary porphyrin...
September 7, 2017: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/28884240/the-serological-markers-of-acute-infection-with-hepatitis-a-b-c-d-e-and-g-viruses-revisited
#12
REVIEW
Robério Amorim de Almeida Pondé
Viral hepatitis is a liver infection caused by one of the six hepatitis viruses: hepatitis A, B, C, D, E, and G virus (HAV to HEV and HGV). These agents differ in their biological, immunological, pathological and epidemiological characteristics. They cause infections that, when symptomatic, lead to clinical manifestations and laboratory findings that are not specific to a particular virus, often making differential diagnosis difficult, especially when no knowledge is available regarding the patient's medical history or the epidemiological background...
September 7, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28881157/identifying-cost-effective-screening-algorithms-for-active-hepatitis-c-virus-infections-in-a-high-prevalence-setting
#13
Paul Jülicher, Claudio Galli
OBJECTIVE: To evaluate the cost-effectiveness of different screening patterns for active chronic hepatitis C virus (HCV) infections utilizing the hepatitis C core antigen test compared to standard care in the context of a general screening program in a high-prevalence country. METHODS: This study developed a decision analytic model to estimate the cost-effectiveness of four screening algorithms for the detection of active HCV infections among asymptomatic individuals with an unknown HCV status in a context of high (>5%) HCV prevalence...
September 7, 2017: Journal of Medical Economics
https://www.readbyqxmd.com/read/28881064/misdiagnosis-of-hepatocellular-carcinoma-in-patients-receiving-no-loco-regional-therapy-prior-to-liver-transplant-an-analysis-of-the-optn-explant-pathology-form
#14
Neil Mehta, Jennifer L Dodge, John P Roberts, Ryutaro Hirose, Francis Y Yao
Patients with T1 hepatocellular carcinoma (HCC) are not eligible for MELD exception for liver transplant (LT) in part due to a high rate of misdiagnosis (no HCC on explant). The likelihood of misdiagnosis for T2 HCC and factors associated with misdiagnosis are unknown. We analyzed the OPTN database including 5664 adults who underwent LT from 2012-2015 with MELD exception for T2 HCC, and searched for no evidence of HCC in the explant pathology file. We focused on those (n=324) receiving no local regional therapy (LRT) to evaluate the probability of no HCC found in explant...
September 7, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28875827/multiple-myeloma-associated-intestinal-amyloidosis-intestinal-pseudo-obstruction-falsely-considered-as-an-ascites
#15
Vladimir Milivojevic, Maja Stojanovic, Ivan Rankovic, Marjan Micev, Rada Jesic Vukicevic, Tomica Milosavljevic
INTRODUCTION: Amyloidosis is a group of diseases pathohistologicaly diagnosed by characteristic extracellular deposition of an abnormal fibrillary protein (i.e. amyloid) into organs, leading to organ dysfunction secondary to destruction of normal tissue architecture. METHOD: Case-report of a 44 year-old female, presenting with massive abdominal distension clinically suspected of ascites. RESULTS: On admission, the patient was complaining of nausea, vomiting, abdominal pain, distension and bloating associated with weight loss and diarrhea...
August 29, 2017: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/28873034/the-absence-of-hcv-rna-and-ns5a-protein-in-peripheral-blood-mononuclear-cells-is-a-prognostic-tool-for-sustained-virological-response
#16
Azhar Mehmood, Muhammad Javaid Asad, Muhammad Ovais, Nasib Zaman, Hafsa Aziz, Javaid Irfan, Irshad Ahmad, Abida Raza
Hepatitis C Virus (HCV) infection is a major health concern worldwide. The presence of both HCV viral RNA and NS5A proteins in peripheral blood mononuclear cells (PBMCs) indicate the efficacy of the treatment during sustained virological response (SVR) and end of treatment response (ETR). The main objective of this study was to detect the absence or presence of HCV RNA and NS5A proteins in PBMCs. Blood samples were taken from selected patients (Islamabad, Pakistan) before treatment, at ETR, and during SVR. Two hundred HCV responders to pegylated IFN-α-2a plus ribavirin were selected...
September 5, 2017: Viral Immunology
https://www.readbyqxmd.com/read/28844561/increased-risk-of-concurrent-hepatitis-c-among-male-patients-with-schizophrenia
#17
Yu-Lung Chiu, Herng-Ching Lin, Nai-Wen Kao, Senyong Kao, Hsin-Chien Lee
Prior studies attempted to explore the association between schizophrenia and hepatitis C virus (HCV). However, their conclusions were inconsistent. This study aimed to examine the association of schizophrenia with HCV using a population-based dataset in Taiwan. There were 6097 patients with schizophrenia and 6097 sex- and age-matched comparison patients without schizophrenia included in this study. We defined the dependent variable of interest as whether or not a patient had received a diagnosis of HCV. We found that of the sampled patients, 2...
August 18, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28843621/early-detection-of-hiv-infection-and-of-asymptomatic-sexually-transmitted-infections-among-men-who-have-sex-with-men
#18
Josep Coll, Sebastián Videla, Agathe Leon, Arelly Ornelas, Felipe García, Emma Fernández, José Luis Blanco, Antonio Carrillo, Isabel Bravo, Michael Meulbroek, Francesc García-Cuyas, Victoria González, Jordi Casabona, Lorna Leal, Bonaventura Clotet, Christian Brander
OBJECTIVE: To provide data on incidence of early diagnosis of HIV infections and define prevalence and incidence of asymptomatic STI in MSM. METHODS: Prospective cohort study of HIV-uninfected MSM at high-risk for HIV-infection. Participants were selected through a risk-assessment questionnaire, and screened for HIV-infection (quarterly) and for other STIs (yearly): syphilis, hepatitis A, B and C (serology); C. trachomatis and N. gonorrhoeae in penis and rectum and Human Papillomavirus in anus and mouth (PCR)...
August 23, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28839428/from-diagnosis-to-treatment-of-hepatocellular-carcinoma-an-epidemic-problem-for-both-developed-and-developing-world
#19
REVIEW
Dimitrios Dimitroulis, Christos Damaskos, Serena Valsami, Spyridon Davakis, Nikolaos Garmpis, Eleftherios Spartalis, Antonios Athanasiou, Demetrios Moris, Stratigoula Sakellariou, Stylianos Kykalos, Gerasimos Tsourouflis, Anna Garmpi, Ioanna Delladetsima, Konstantinos Kontzoglou, Gregory Kouraklis
Hepatocellular carcinoma (HCC) is the most frequent primary liver malignancy and the third cause of cancer-related death in the Western Countries. The well-established causes of HCC are chronic liver infections such as hepatitis B virus or chronic hepatitis C virus, nonalcoholic fatty liver disease, consumption of aflatoxins and tobacco smocking. Clinical presentation varies widely; patients can be asymptomatic while symptomatology extends from right upper abdominal quadrant paint and weight loss to obstructive jaundice and lethargy...
August 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28833342/the-higher-prevalence-of-truncal-obesity-and-diabetes-in-american-than-chinese-patients-with-chronic-hepatitis-c-might-contribute-to-more-rapid-progression-to-advanced-liver-disease
#20
H Rao, E Wu, S Fu, M Yang, B Feng, A Lin, R Fei, R J Fontana, A S Lok, L Wei
BACKGROUND: Chronic hepatitis C virus (HCV) infection is the leading cause of cirrhosis and hepatocellular carcinoma (HCC) in the United States (US) and an emerging cause in China. AIM: To compare the clinical characteristics of hepatitis C patients in the US and China, and factors influencing disease stage. METHODS: Prospective study of 2 cohorts of HCV patients recruited at 1 site in the US and 3 sites in China. Standardised questionnaire on risk factors and medical history were used and diagnosis of cirrhosis and HCC was based on pre-defined criteria...
August 22, 2017: Alimentary Pharmacology & Therapeutics
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