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https://www.readbyqxmd.com/read/27639087/integration-of-ligand-and-structure-based-approaches-for-identification-of-novel-mbti-inhibitors-in-mycobacterium-tuberculosis-and-molecular-dynamics-simulation-studies
#1
Lakshmi Maganti, Pradeep Grandhi, Nanda Ghoshal
Mycobacterium tuberculosis is an obligate pathogen of mammals and is responsible for more than two million deaths annually. The ability to acquire iron from the extracellular environment is a key determinant of pathogenicity in mycobacteria. M. tuberculosis acquires iron exclusively through the siderophores. Several lines of evidence suggest that siderophores have a critical role in bacterial growth and virulence. Hence, in the present study, we have used a combined ligand and structure-based drug design approach for identification of novel inhibitors against salicylate synthase MbtI, a unique and essential enzyme for the biosynthesis of siderophores in M...
September 5, 2016: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/27302443/the-role-of-the-myers-briggs-personality-type-and-emotional-intelligence-in-marital-satisfaction-among-married-female-students-at-tehran-university
#2
Galin Shirzad
The present descriptive correlational study was conducted to predict the role of emotional intelligence and the Myers-Briggs personality type in marital satisfaction in married female students Tehran University in 2015. The study population consisted of all the married female students at Tehran University who visited Iran MBTI center between 22.04.2015 and 21.06.2015. A total of 140 students were selected as the study samples. Data were collected using the Myer-Briggs Type Indicator, the Bar-On Emotional Intelligence Questionnaire and the Enrich Marital Satisfaction Scale and were then analyzed in SPSS-20 using the multivariate regression analysis...
1, 2016: Global Journal of Health Science
https://www.readbyqxmd.com/read/27281295/iron-acquisition-pathways-as-targets-for-antitubercular-drugs
#3
Fiorella Meneghetti, Stefania Villa, Arianna Gelain, Daniela Barlocco, Laurent Roberto Chiarelli, Maria Rosalia Pasca, Luca Costantino
Tuberculosis nowadays ranks as the second leading cause of death from an infectious disease worldwide. In the last twenty years, this disease has again started to spread mainly for the appearance of multi-drug resistant forms. Therefore, new targets are needed to address the growing emergence of bacterial resistance and for antitubercular drug development. Efficient iron acquisition is crucial for the pathogenesis of Mycobacterium tuberculosis, because it serves as cofactor in many essential biological processes, including DNA biosynthesis and cellular respiration...
June 7, 2016: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/27192365/myers-briggs-typology-and-jungian-individuation
#4
Steve Myers
Myers-Briggs typology is widely seen as equivalent to and representative of Jungian theory by the users of the Myers-Briggs Type Indicator (MBTI) and similar questionnaires. However, the omission of the transcendent function from the theory, and the use of typological functions as its foundation, has resulted in an inadvertent reframing of the process of individuation. This is despite some attempts to integrate individuation and typology, and reintroduce the transcendent function into Myers-Briggs theory. This paper examines the differing views of individuation in Myers-Briggs and Jungian theory, and some of the challenges of reconciling those differences, particularly in the context of normality...
June 2016: Journal of Analytical Psychology
https://www.readbyqxmd.com/read/26951414/examining-the-variability-of-sleep-patterns-during-treatment-for-chronic-insomnia-application-of-a-location-scale-mixed-model
#5
Jason C Ong, Donald Hedeker, James K Wyatt, Rachel Manber
STUDY OBJECTIVES: The purpose of this study was to introduce a novel statistical technique called the location-scale mixed model that can be used to analyze the mean level and intra-individual variability (IIV) using longitudinal sleep data. METHODS: We applied the location-scale mixed model to examine changes from baseline in sleep efficiency on data collected from 54 participants with chronic insomnia who were randomized to an 8-week Mindfulness-Based Stress Reduction (MBSR; n = 19), an 8-week Mindfulness-Based Therapy for Insomnia (MBTI; n = 19), or an 8-week self-monitoring control (SM; n = 16)...
2016: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/26851600/the-association-between-myers-briggs-type-indicator-and-psychiatry-as-the-specialty-choice
#6
Chong Yang, George Richard, Martin Durkin
OBJECTIVE: The purpose of this pilot study is to examine the association between Myers-Briggs Type Indicator (MBTI) and prospective psychiatry residents. METHODS: Forty-six American medical schools were contacted and asked to participate in this study. Data were collected and an aggregated list was compiled that included the following information: date of MBTI administration, academic year, MBTI form/version, residency match information and student demographic information...
2016: International Journal of Medical Education
https://www.readbyqxmd.com/read/26835528/influence-of-personality-on-tooth-shade-selection
#7
Satheesh B Haralur, Khalid Saleh Al-Shehri, Hassan Mohammed Assiri, Mushabab AbdulRahman Al-Qahtani
PURPOSE: The harmonious shade matching of restorations with adjacent natural teeth is a prerequisite for a successful esthetic restoration. Color is a combined effect of the physical properties of an object, the light source, and the perception of the observer. The interpretation of color is influenced by both the physiological and psychological health of an individual. It is critical to understand the influence of an individual's psychological state on the shade selection procedure to achieve better shade matching and post-treatment patient counseling...
2016: International Journal of Esthetic Dentistry
https://www.readbyqxmd.com/read/26390335/the-value-of-mindfulness-meditation-in-the-treatment-of-insomnia
#8
REVIEW
Joanne Martires, Michelle Zeidler
PURPOSE OF REVIEW: Insomnia is the most common reported sleep disorder with limited treatment options including pharmacotherapy and cognitive behavioral therapy for insomnia. Pharmacotherapy can be complicated by tolerance and significant side-effects and cognitive behavioral therapy for insomnia providers are limited in number. This article reviews mindfulness meditation as an additional therapy for insomnia. RECENT FINDINGS: Both mindfulness-based stress reduction (MBSR) and mindfulness-based therapy for insomnia (MBTI) have been studied in the treatment of insomnia...
November 2015: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/26035083/stereocontrolled-synthesis-of-a-potential-transition-state-inhibitor-of-the-salicylate-synthase-mbti-from-mycobacterium-tuberculosis
#9
Zheng Liu, Feng Liu, Courtney C Aldrich
Mycobactins are small-molecule iron chelators (siderophores) produced by Mycobacterium tuberculosis (Mtb) for iron mobilization. The bifunctional salicylate synthase MbtI catalyzes the first step of mycobactin biosynthesis through the conversion of the primary metabolite chorismate into salicylic acid via isochorismate. We report the design, synthesis, and biochemical evaluation of an inhibitor based on the putative transition state (TS) for the isochorismatase partial reaction of MbtI. The inhibitor mimics the hypothesized charge buildup at C-4 of chorismate in the TS as well as C-O bond formation at C-6...
July 2, 2015: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/25800264/change-of-acknowledgments-in-the-relationship-between-dental-graduate-students-mbti-types-and-academic-achievement-in-problem-based-learning
#10
(no author information available yet)
No abstract text is available yet for this article.
March 2015: Korean Journal of Medical Education
https://www.readbyqxmd.com/read/25800261/how-to-provide-tailored-career-coaching-for-medical-students
#11
Yera Hur, A Ra Cho, Sun Kim
PURPOSE: This study was performed to develop a counseling strategy, based on the profiles of medical students' Strong Interest Inventory (STRONG) and Myer-Briggs Type Indicator (MBTI) results, focusing on the three following questions: Into what distinct levels are students categorized by STRONG and MBTI? and What is the dispersion of the integrated profiles? METHODS: Freshmen students from Konyang University College of Medicine who matriculated between March 2011 and 2013 were administered the MBTI personality type test and the STRONG interest inventory assessment...
March 2015: Korean Journal of Medical Education
https://www.readbyqxmd.com/read/25800236/-the-relationship-between-dental-graduate-students-mbti-types-and-academic-achievement-in-problem-based-learning
#12
Min-Jin Kim, Kyung-Pyo Park, Deog-Gyu Seo, Jung-Joon Ihm
PURPOSE: The study aimed to determine the personality types of the graduate students in Seoul National University School of Dentistry (SNU SD) and analyze the specific personal types that were linked to their performance in problem-based learning (PBL). METHODS: A total of 263 graduate students in SNU SD from 2011 to 2013, participated in PBL and completed the Myers-Briggs Type Indicator (MBTI) GS form, which was analyzed statistically to determine whether their MBTI personality types were independent of their PBL performance...
December 2014: Korean Journal of Medical Education
https://www.readbyqxmd.com/read/25586582/a-new-salicylate-synthase-ams-is-identified-for-siderophores-biosynthesis-in-amycolatopsis-methanolica-239-t
#13
Feng Xie, Shengwang Dai, Jinzhao Shen, Biao Ren, Pei Huang, Qiushui Wang, Xueting Liu, Buchang Zhang, Huanqin Dai, Lixin Zhang
Siderophores are important for the growth of bacteria or the applications in treatment of iron overload-associated diseases due to the iron-chelating property. Salicylate synthase played a key role in the biosynthesis of some NRPS-derived siderophores by the providing of an iron coordination moiety as the initial building block. A new salicylate synthase, namely AmS, was identified in the biosynthesis pathway of siderophore amychelin in Amycolatopsis methanolica 239(T), since it shunt chorismate, an integrant precursor, from primary to secondary metabolite flow...
July 2015: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/25345890/an-exploratory-study-of-the-relationship-between-learning-styles-and-academic-performance-among-students-in-different-nursing-programs
#14
Yuh-Shiow Li, Wen-Pin Yu, Chin-Fang Liu, Sue-Heui Shieh, Bao-Huan Yang
Abstract Background: Learning style is a major consideration in planning for effective and efficient instruction and learning. Learning style has been shown to influence academic performance in the previous research. Little is known about Taiwanese students' learning styles, particularly in the field of nursing education. Aim: This purpose of this study was to identify the relationship between learning styles and academic performance among nursing students in a five-year associate degree of nursing (ADN) program and a two-year bachelor of science in nursing (BSN) program in Taiwan...
October 27, 2014: Contemporary Nurse
https://www.readbyqxmd.com/read/25214695/a-randomized-controlled-trial-of-mindfulness-meditation-for-chronic-insomnia
#15
Jason C Ong, Rachel Manber, Zindel Segal, Yinglin Xia, Shauna Shapiro, James K Wyatt
STUDY OBJECTIVES: To evaluate the efficacy of mindfulness meditation for the treatment of chronic insomnia. DESIGN: Three-arm, single-site, randomized controlled trial. SETTING: Academic medical center. PARTICIPANTS: Fifty-four adults with chronic insomnia. INTERVENTIONS: Participants were randomized to either mindfulness-based stress reduction (MBSR), mindfulness-based therapy for insomnia (MBTI), or an eight-week self-monitoring (SM) condition...
2014: Sleep
https://www.readbyqxmd.com/read/25142566/a-randomized-controlled-trial-of-mindfulness-meditation-for-chronic-insomnia
#16
RANDOMIZED CONTROLLED TRIAL
Jason C Ong, Rachel Manber, Zindel Segal, Yinglin Xia, Shauna Shapiro, James K Wyatt
STUDY OBJECTIVES: To evaluate the efficacy of mindfulness meditation for the treatment of chronic insomnia. DESIGN: Three-arm, single-site, randomized controlled trial. SETTING: Academic medical center. PARTICIPANTS: Fifty-four adults with chronic insomnia. INTERVENTIONS: Participants were randomized to either mindfulness-based stress reduction (MBSR), mindfulness-based therapy for insomnia (MBTI), or an eight-week self-monitoring (SM) condition...
September 1, 2014: Sleep
https://www.readbyqxmd.com/read/24946256/missing-a-follow-up-after-mild-traumatic-brain-injury-does-it-matter
#17
Eirik Vikane, Torgeir Hellstrøm, Cecilie Røe, Erik Bautz-Holter, Jörg Assmus, Jan Sture Skouen
OBJECTIVE: This study sought to identify potential differing clinical characteristics between patients with a mild traumatic brain injury (MTBI) who attended a planned follow-up session and not. This study investigated whether clinical characteristics and attendance for a planned follow-up service 2-months after injury could be related to return-to-work (RTW) 1-year later. METHOD: Prospective cohort study of 343 patients with MTBI admitted consecutively to the Department of Neurosurgery in 2009-2011...
2014: Brain Injury: [BI]
https://www.readbyqxmd.com/read/24706688/personality-preference-distribution-of-dental-students-admitted-to-one-dental-school-using-different-selection-methods
#18
COMPARATIVE STUDY
Hsingchi von Bergmann, Kirsten R Dalrymple, Charles F Shuler
This study sought to determine whether using the Myers-Briggs Type Indicator (MBTI) would detect differences in personality preferences in first-year dental students admitted to the same dental school through different admission methods. First-year dental students admitted in 2000 and 2001 were given the MBTI instrument during orientation prior to the start of classes. In fall 2000, the Class of 2004 had 140 students, with 116 in the traditional track and twenty-four in the parallel problem-based learning (PBL) track...
April 2014: Journal of Dental Education
https://www.readbyqxmd.com/read/24209660/the-influence-of-surgeon-personality-factors-on-risk-tolerance-a-pilot-study
#19
REVIEW
Jack Contessa, Luis Suarez, Tassos Kyriakides, Geoffrey Nadzam
OBJECTIVE: This study attempts to assess the association between surgeon personality factors (measured by the Myers-Briggs Type Indicator personality inventory (MBTI(®))) and risk tolerance (measured by the Revised Physicians' Reactions to Uncertainty (PRU) and Physician Risk Attitude (PRA) scales). DESIGN: Instrument assessing surgeon personality profile (MBTI) and 2 questionnaires measuring surgeon risk tolerance and risk aversion (PRU and PRA). SETTING: Saint Raphael campus of Yale New Haven Hospital in New Haven, Connecticut...
November 2013: Journal of Surgical Education
https://www.readbyqxmd.com/read/23944668/personality-type-in-occupational-therapy-students-implications-for-teaching-and-learning-strategies
#20
Paula W Jamison, Diane Dirette
SUMMARY In this descriptive study, 130 occupational therapy students completed a widely-used personality inventory (the MBTI-M) as part of coursework in their first semester. The majority of students evinced a preference for seven out of the 16 possible personality types; one type was not selected by anyone. These findings closely resembled data from the 1970s on practicing occupational therapists. Common characteristics, such as a high premium on personal connectedness and a dependable working environment, have important implications for faculty...
2004: Occupational Therapy in Health Care
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