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https://www.readbyqxmd.com/read/28212155/molecular-markers-in-lung-cancer-role-of-ebus
#1
Semra Bilaçeroğlu
PURPOSE OF REVIEW: As demonstrated by the recent therapeutic advances in nonsmall cell lung cancer (NSCLC), a personalized approach can considerably reduce its mortality. RECENT FINDINGS: Molecular tests identifying genetic mutations in NSCLC have led to a shift towards more effective and personalized therapies targeted to these alterations. Adequate tissue is required for diagnosing, subcharacterizing, and genotyping NSCLC by morphological, immunohistochemical, and molecular techniques...
February 16, 2017: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/28212154/optical-coherence-tomography-and-confocal-laser-endomicroscopy-in-pulmonary-diseases
#2
Lizzy Wijmans, Julia N S d'Hooghe, Peter I Bonta, Jouke T Annema
PURPOSE OF REVIEW: Current imaging techniques (X-ray, computed tomography scan, ultrasound) have limitations in the identification and quantification of pulmonary diseases, in particular, on highly detailed level. The purpose of this review is to provide an overview of the current knowledge of innovative light- and laser-based imaging techniques that might fill this gap. RECENT FINDINGS: Optical coherence tomography (OCT) and confocal laser endomicroscopy (CLE) are high-resolution imaging techniques, which, combined with bronchoscopy, provide 'near histology' detailed imaging of the airway wall, lung parenchyma, mediastinal lymph nodes, and pulmonary vasculature...
February 16, 2017: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/28212115/predictor-of-hand-radiological-progression-in-patients-with-rheumatoid-arthritis-receiving-tnf-antagonist-therapy-by-change-in-grayscale-synovitis-a-preliminary-study
#3
Ying-Chou Chen, Fu-Mei Su, Shih-Wei Hsu, Jia-Feng Chen, Tien-Tsai Cheng, Han-Ming Lai, Wen-Chan Chiu
OBJECTIVES: This prospective study aimed to compare synovial ultrasound scores to conventional measures (DAS28, CRP levels) in predicting radiographic progression in patients with rheumatoid arthritis under TNF antagonist therapy. METHODS: Patients with RA who received TNF antagonist therapy were enrolled, all of whom underwent clinical, laboratory, and ultrasonographic assessments with grayscale and power Doppler assessments of bilateral elbows (anterior and posterior recess), wrists (dorsal, palmar, and ulnar aspects), second and third MCP joints (dorsal and palmar recess), and PIP II and III (dorsal and palmar) at baseline and at 1, 3 months...
February 17, 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/28212081/a-comparative-analysis-of-cmut-receiving-architectures-for-design-optimization-of-integrated-transceiver-front-ends
#4
Marco Sautto, Alessandro Stuart Savoia, Fabio Quaglia, Giosue Caliano, Andrea Mazzanti
A formal comparison between fundamental RX amplifier configurations for Capacitive Micromachined Ultrasonic Transducers (CMUT) is proposed in this paper. The impact on both RX and the pulse-echo frequency response and on the output SNR are thoroughly analysed and discussed. It is shown that the resistive-feedback amplifier yields a band-pass RX frequency response, while both open-loop voltage and capacitivefeedback amplifiers exhibit a low-pass frequency response. For a given power dissipation, it is formally proved that a capacitivefeedback amplifier provides a remarkable SNR improvement against the commonly adopted resistive feedback stage, achieved at the expense of a reduced pulse-echo center frequency, making its use convenient in low and mid-frequency ultrasound imaging applications...
February 13, 2017: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/28211980/constitutional-bone-impairment-in-noonan-syndrome
#5
Giuseppina Baldassarre, Alessandro Mussa, Diana Carli, Cristina Molinatto, Giovanni Battista Ferrero
Noonan syndrome (NS) is an autosomal dominant trait characterized by genotypic and phenotypic variability. It belongs to the Ras/MAPK pathway disorders collectively named Rasopathies or neurocardiofaciocutaneous syndromes. Phenotype is characterized by short stature, congenital heart defects, facial dysmorphisms, skeletal and ectodermal anomalies, cryptorchidism, mild to moderate developmental delay/learning disability, and tumor predisposition. Short stature and skeletal dysmorphisms are almost constant and several studies hypothesized a role for the RAS pathway in regulating bone metabolism...
March 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28211807/two-dimensional-shear-wave-elastography-of-breast-lesions-comparison-of-two-different-systems
#6
Wei-Wei Ren, Xiao-Long Li, Ya-Ping He, Dan-Dan Li, Dan Wang, Chong-Ke Zhao, Xiao-Wan Bo, Bo-Ji Liu, Wen-Wen Yue, Hui-Xiong Xu
OBJECTIVE: To evaluate the diagnostic performance of two different shear wave elastography (SWE) techniques in distinguishing malignant breast lesions from benign ones. MATERIALS AND METHODS: From March 2016 to May 2016, a total of 153 breast lesions (mean diameter, 16.8 mm±10.5; range 4.1-90.0 mm) in 153 patients (mean age, 46.4 years±15.1; age range 20-86 years) were separately performed by two different SWE techniques (i.e. T-SWE, Aplio500, Toshiba Medical System, Tochigi, Japan; and S-SWE, the Aixplorer US system, SuperSonic Imagine, Provence, France)...
February 17, 2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/28211805/diagnostic-accuracy-and-interobserver-variability-of-dynamic-vascular-pattern-dvp-in-primary-liver-malignancies-a-simple-semiquantitative-tool-for-the-analysis-of-contrast-enhancement-patterns
#7
B Schellhaas, M J Waldner, R S GÖrtz, F Vitali, Ch Kielisch, L Pfeifer, D Strobel, R Janka, M F Neurath, D Wildner
BACKGROUND: Contrast-enhanced ultrasound (CEUS) is a valuable tool in the diagnostic approach of focal liver lesions, but occasionally subjective and observer-dependent. Semiquantitative evaluation of dynamic CEUS (DCEUS) with standardised software programmes such as Dynamic Vascular Pattern (DVP) could help to improve diagnostic accuracy and objectivity in liver tumour assessment. OBJECTIVES: The present study aimed at evaluation of diagnostic accuracy of DVP in a clinical setting...
February 17, 2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/28211804/comparison-of-elastography-based-on-transvaginal-ultrasound-and-mri-in-assessing-parametrial-invasion-of-cervical-cancer
#8
Xi Ma, Qi Li, Jian-Liang Wang, Jun Shao, Yu-Chun Zhu, Wei Ding, Hou-Sheng Zhang, Hong-Yan Wang, Jun-Kang Shen
OBJECTIVE: The purpose of this study was to evaluate the clinical value of transvaginal elastography (TVES) combined with high-resolution transvaginal ultrasound (TVS) in the detection of parametrial invasion in cervical cancer and to compare the diagnostic performance with magnetic resonance imaging (MRI). MATERIALS AND METHODS: 52 women with histologically confirmed cervical cancer over a 2-year period were staged using International Federation of Gynecology and Obstetrics (FIGO) criteria and underwent MRI and TVES combined with TVS according to a standardized protocol before treatment...
February 17, 2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/28211702/antimicrobial-effect-of-biocompatible-silicon-nanoparticles-activated-by-therapeutic-ultrasound
#9
Svetlana N Shevchenko, Markus Burkhardt, Eugene V Sheval, Ulyana A Natashina, Christina Große, Alexander L Nikolaev, Alexander V Gopin, Ute Neugebauer, Andrew A Kudryavtsev, Vladimir Sivakov, Liubov Andreevna Osminkina
In this study, we report on a method for suppressing of Escherichia coli (E.coli) vitality by means of therapeutic ultrasound irradiation (USI) using biocompatible silicon nanoparticles as cavitation sensitizers. Silicon nanoparticles without (SiNPs) and with polysaccharide (dextran) coating (DSiNPs) were used. Both types of nanoparticles were non-toxic to Hep 2 cells up to concentration of 2 mg/ml. The treatment of bacteria with nanoparticles and application of 1 W/cm2 USI resulted in reduction of their viability up to 35% and 72% for SiNPs and DSiNPs, respectively...
February 17, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28211622/mri-guided-focused-ultrasound-robotic-system-for-animal-experiments
#10
Marinos Yiannakou, Georgios Menikou, Christos Yiallouras, Cleanthis Ioannides, Christakis Damianou
BACKGROUND: In this paper an MRI-guided focused ultrasound (MRgFUS) robotic system was developed that can be used for conducting experiments in small animals.The target for this robotic system regarding motion was to move a therapeutic ultrasound transducer in two Cartesian axes. METHODS: A single element spherically focused transducer of 3 cm diameter, focusing at 7 cm and operating at 0.4 MHz was used. The positioning device incorporates only MRI compatible materials...
February 17, 2017: International Journal of Medical Robotics + Computer Assisted Surgery: MRCAS
https://www.readbyqxmd.com/read/28211610/fibroid-vascularisation-assessed-with-three-dimensional-power-doppler-ultrasound-is-a-predictor-for-uterine-fibroid-growth-a-prospective-cohort-study
#11
L L Nieuwenhuis, A L Keizer, B Stoelinga, J W R Twisk, W J K Hehenkamp, H A M Brölmann, J A F Huirne
OBJECTIVE: To analyse fibroid vascularisation measured with 3D Power Doppler in relation to absolute fibroid volume change during 12 months follow up and in relation to fibroid growth rate per year DESIGN: A prospective cohort study was performed between March 2012 and March 2014. SETTING: Outpatient clinic of the VU medical centre, Amsterdam. POPULATION OR SAMPLE: All premenopausal women diagnosed with a maximum of 2 fibroids with expectative management were consecutively included...
February 17, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28211510/broadband-gradient-impedance-matching-using-an-acoustic-metamaterial-for-ultrasonic-transducers
#12
Zheng Li, Dan-Qing Yang, Shi-Lei Liu, Si-Yuan Yu, Ming-Hui Lu, Jie Zhu, Shan-Tao Zhang, Ming-Wei Zhu, Xia-Sheng Guo, Hao-Dong Wu, Xin-Long Wang, Yan-Feng Chen
High-quality broadband ultrasound transducers yield superior imaging performance in biomedical ultrasonography. However, proper design to perfectly bridge the energy between the active piezoelectric material and the target medium over the operating spectrum is still lacking. Here, we demonstrate a new anisotropic cone-structured acoustic metamaterial matching layer that acts as an inhomogeneous material with gradient acoustic impedance along the ultrasound propagation direction. When sandwiched between the piezoelectric material unit and the target medium, the acoustic metamaterial matching layer provides a broadband window to support extraordinary transmission of ultrasound over a wide frequency range...
February 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28211471/phosphorene-quantum-dot-saturable-absorbers-for-ultrafast-fiber-lasers
#13
J Du, M Zhang, Z Guo, J Chen, X Zhu, G Hu, P Peng, Z Zheng, H Zhang
We fabricate ultrasmall phosphorene quantum dots (PQDs) with an average size of 2.6 ± 0.9 nm using a liquid exfoliation method involving ultrasound probe sonication followed by bath sonication. By coupling the as-prepared PQDs with microfiber evanescent light field, the PQD-based saturable absorber (SA) device exhibits ultrafast nonlinear saturable absorption property, with an optical modulation depth of 8.1% at the telecommunication band. With the integration of the all-fiber PQD-based SA, a continuous-wave passively mode-locked erbium-doped (Er-doped) laser cavity delivers stable, self-starting pulses with a pulse duration of 0...
February 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28211204/evaluation-of-the-enhanced-permeability-and-retention-effect-in-the-early-stages-of-lymph-node-metastasis
#14
Mamoru Mikada, Ariunbuyan Sukhbaatar, Yoshinobu Miura, Sachiko Horie, Maya Sakamoto, Shiro Mori, Tetsuya Kodama
Most solid cancers spread to new sites via the lymphatics before hematogenous dissemination. However, only a small fraction of an intravenously administered anti-cancer drug enters the lymphatic system to reach metastatic lymph nodes (LNs). Here, we show that the enhanced permeability and retention (EPR) effect is not induced during the early stages of LN metastasis. Luciferase-expressing tumor cells were injected into the subiliac LN of the MXH10/Mo-lpr/lpr mouse to induce metastasis to the proper axillary LN (PALN)...
February 17, 2017: Cancer Science
https://www.readbyqxmd.com/read/28211004/point-of-care-ultrasound-and-doppler-ultrasound-evaluation-of-vascular-injuries-in-penetrating-and-blunt-trauma
#15
REVIEW
Miguel Angel Montorfano, Fernando Pla, Leonardo Vera, Omar Cardillo, Stefano Geniere Nigra, Lisandro Miguel Montorfano
BACKGROUND: The aim of this study is to describe point-of-care ultrasound and Color flow Duplex Doppler characteristics of penetrating and blunt trauma-related vascular injuries of the limbs and neck. METHODS: Penetrating and blunt trauma-related vascular injuries such as vein disruption, intimal flap, deep vein thrombosis, arterial dissection, pseudoaneurysm, and arteriovenous fistulae are discussed in this manuscript. Images of the most significant lesions of our personal clinical experience are presented to illustrate point-of-care ultrasound and Color flow Duplex Doppler ultrasound findings...
December 2017: Critical Ultrasound Journal
https://www.readbyqxmd.com/read/28211003/an-easy-to-build-low-budget-point-of-care-ultrasound-simulator-from-linux-to-a-web-based-solution
#16
Domagoj Damjanovic, Ulrich Goebel, Benedikt Fischer, Martin Huth, Hartmut Breger, Hartmut Buerkle, Axel Schmutz
BACKGROUND: Hands-on training in point-of-care ultrasound (POC-US) should ideally comprise bedside teaching, as well as simulated clinical scenarios. High-fidelity phantoms and portable ultrasound simulation systems are commercially available, however, at considerable costs. This limits their suitability for medical schools. A Linux-based software for Emergency Department Ultrasound Simulation (edus2TM) was developed by Kulyk and Olszynski in 2011. Its feasibility for POC-US education has been well-documented, and shows good acceptance...
December 2017: Critical Ultrasound Journal
https://www.readbyqxmd.com/read/28210824/ultrasound-palpation-for-fast-in-situ-quantification-of-articular-cartilage-stiffness-thickness-and-relaxation-capacity
#17
M Schöne, R M Schulz, H Tzschätzsch, P Varga, K Raum
Most current cartilage testing devices require the preparation of excised samples and therefore do not allow intra-operative application for diagnostic purposes. The gold standard during open or arthroscopic surgery is still the subjective perception of manual palpation. This work presents a new diagnostic method of ultrasound palpation (USP) to acquire applied stress and strain data during manual palpation of articular cartilage. With the proposed method, we obtain cartilage thickness and stiffness. Moreover, repeated palpations allow the quantification of relaxation effects...
February 16, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28210800/preservation-of-the-endometrial-enhancement-after-magnetic-resonance-imaging-guided-high-intensity-focused-ultrasound-ablation-of-submucosal-uterine-fibroids
#18
Young-Sun Kim, Tae-Joong Kim, Hyo Keun Lim, Hyunchul Rhim, Sin-Ho Jung, Joong Hyun Ahn, Jeong-Won Lee, Byoung-Gie Kim
OBJECTIVE: To evaluate the integrity of endometrial enhancement after magnetic resonance imaging-guided high-intensity focused ultrasound (MR-HIFU) ablation of submucosal uterine fibroids based on contrast-enhanced MRI findings, and to identify the risk factors for endometrial impairment. METHODS: In total, 117 submucosal fibroids (diameter: 5.9 ± 3.0 cm) in 101 women (age: 43.6 ± 4.4 years) treated with MR-HIFU ablation were retrospectively analysed...
February 16, 2017: European Radiology
https://www.readbyqxmd.com/read/28210714/fetal-cholelithiasis-antenatal-diagnosis-and-neonatal-follow-up-in-a-case-of-twin-pregnancy-a-case-report-and-review-of-the-literature
#19
Yannick Hurni, Francesco Vigo, Begoña Lipp von Wattenwyl, Nicole Ochsenbein, Claudia Canonica
Fetal cholelithiasis is a rare finding during a third-trimester ultrasound with an average incidence rate of 0.07-1.15%. We report a case of fetal cholelithiasis in twins, observed in a patient with monochorionic diamniotic twin pregnancy hospitalized at our unit for signs of premature labor. We present the outcome of the 2 neonates with a clinical and sonographic follow-up. In addition, we offer a comprehensive review of the literature available to date.
February 2017: Ultrasound International Open
https://www.readbyqxmd.com/read/28210709/clinical-outcomes-of-eus-guided-drainage-of-debris-containing-pancreatic-pseudocysts-a-large-multicenter-study
#20
Dennis Yang, Sunil Amin, Susana Gonzalez, Daniel Mullady, Steven A Edmundowicz, John M DeWitt, Mouen A Khashab, Andrew Y Wang, Satish Nagula, Jonathan M Buscaglia, Juan Carlos Bucobo, Mihir S Wagh, Peter V Draganov, Tyler Stevens, John J Vargo, Harshit S Khara, David L Diehl, Rajesh N Keswani, Srinadh Komanduri, Patrick S Yachimski, Anoop Prabhu, Richard S Kwon, Rabindra R Watson, Adam J Goodman, Petros Benias, David L Carr-Locke, Christopher J DiMaio
Background and study aims Data on clinical outcomes of endoscopic drainage of debris-free pseudocysts (PDF) versus pseudocysts containing solid debris (PSD) are very limited. The aims of this study were to compare treatment outcomes between patients with PDF vs. PSD undergoing endoscopic ultrasound (EUS)-guided drainage via transmural stents. Patients and methods Retrospective review of 142 consecutive patients with pseudocysts who underwent EUS-guided transmural drainage (TM) from 2008 to 2014 at 15 academic centers in the United States...
February 2017: Endoscopy International Open
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