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https://www.readbyqxmd.com/read/29775451/-recurrent-urolithiasis-as-a-symptom-of-primary-hyperparathyroidism-in-a-16-year-old-boy
#1
Monika Wojciechowska, Beata Bieniaś, Aleksandra Sobieszczańska-Droździel, Anna Wieczorkiewicz-Płaza, Iwona Beń-Skowronek, Przemysław Sikora
Primary hyperparathyroidism is one of the most common endocrine diseases, however, it is rare in children. In most cases, it is caused by adenoma of these organs. Its most common complications include urolithiasis, nephrocalcinosis and osteoporosis. CASE REPORT: A 16-year-old patient was admitted to our Clinic because of his first-ever renal colic. The ultrasound examination revealed rightsided hydronephrosis caused by the presence of 9 mm stone in the upper part of the right ureter. In addition, the presence of 8 mm stone in the middle calyx of the left kidney was found...
April 23, 2018: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29775417/targeting-histone-methyltransferase-enhancer-of-zeste-homolog-2-inhibits-renal-epithelial-mesenchymal-transition-and-attenuates-renal-fibrosis
#2
Xiaoxu Zhou, Chongxiang Xiong, Evelyn Tolbert, Ting C Zhao, George Bayliss, Shougang Zhuang
Enhancer of zeste homolog-2 (EZH2) is a methyltransferase that induces histone H3 lysine 27 trimethylation (H3K27me3) and functions as an oncogenic factor in many cancer types. Its role in renal epithelial-mesenchymal transition (EMT) remains unknown. In this study, we found that EZH2 and H3K27me3 were highly expressed in mouse kidney with unilateral ureteral obstruction and cultured mouse kidney proximal tubular (TKPT) cells undergoing EMT. Inhibition of EZH2 with 3-deazaneplanocin A (3-DZNeP) attenuated renal fibrosis, which was associated with preserving E-cadherin expression and inhibiting Vimentin up-regulation in the obstructed kidney...
May 18, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29774807/robotic-pyelolithotomy-extended-pyelolithotomy-nephrolithotomy-and-anatrophic-nephrolithotomy
#3
Rabii Madi, Ashok Hemal
INTRODUCTION: We are a reporting on the indications, techniques, and limitations of robotic surgery in the management of renal stones disease. Robotic surgery is a good tool to manage large kidney and ureteral stones, particularly in patients with anatomic anomalies. We describe three techniques in managing staghorn kidney stones: robotic anatrophic nephrolithotomy, robotic pyelolithotomy, and robotic nephrolithotomy. MATERIAL AND METHODS: Robotic pyelolithotomy (RP) is ideal for patients with large renal pelvis and partial staghorn stone with a wide extra-renal pelvis...
May 2018: Journal of Endourology
https://www.readbyqxmd.com/read/29772616/-recurrent-urothelial-carcinoma-in-the-uretero-vesical-junction-treated-with-partial-ureterectomy-and-ureteroneocystostomy-during-long-term-follow-up-a-case-report
#4
Soichiro Shimura, Kazumasa Matsumoto, Ken-Ichi Tabata, Tetsuo Fujita, Masatsugu Iwamura
A 54-year-old woman who had been treated with transurethral resection of bladder tumor for nonmuscle invasive urothelial carcinoma approximately nine years before presented with gross hematuria. Cystoscopy demonstrated a papillary tumor at the left side of the ureteral orifice. Magnetic resonance imaging showed a 1.3 cm non-muscle invasive lesion in the lower ureter from the ureteral orifice. She suffered from connective tissue disease treated with steroids. To avoid renal failure, we performed partial ureterectomy and ureteroneocystostomy...
April 2018: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/29772114/effect-of-highly-concentrated-hyaluronic-acid-chondroitin-sulfate-instillation-on-ureteral-stent-induced-discomfort-after-ureteroscopic-lithotripsy-a-multicenter-randomized-controlled-pilot-study
#5
Jung Ki Jo, Jae Heon Kim, Kyu Shik Kim, Jae Hoon Chung, Sung Yul Park, Yong Tae Kim, Hong Yong Choi, Eun-Seop Song, Bora Lee, Seung Wook Lee
OBJECTIVE: To investigate the efficacy and safety of instilling highly concentrated hyaluronic acid (HA)/chondroitin sulfate (CS) on the ureteral stent-related pain, urinary symptoms, and quality of life (QoL) of patients who underwent ureteroscopic lithotripsy for ureter stones followed by ureteral stent placement. PATIENTS AND METHODS: Eligible patients were randomly allocated to receive intravesical instillation with HA/CS or normal saline just after ureteral stent placement...
May 17, 2018: BJU International
https://www.readbyqxmd.com/read/29771425/fhl2-participates-in-renal-interstitial-fibrosis-by-altering-the-phenotype-of-renal-tubular-epithelial-cells-via-regulating-the-%C3%AE-catenin-pathway
#6
S-G Zhou, H-J Ma, Z-Y Guo, W Zhang, X Yang
OBJECTIVE: To investigate the potential role of FHL2 (four and a half LIM domains protein 2) in the renal interstitial fibrosis and its underlying mechanism. MATERIALS AND METHODS: NRK-52E, the rat tubular epithelial cell line, was selected for the in vitro experiments. The unilateral ureteral obstruction (UUO) mouse model and phenotype changes of NRK-52E cells were induced by TGF-β (transforming growth factor-β) treatment. Protein and mRNA expressions of biomarkers of tubular cells and renal fibrosis in NRK-52E cells were detected...
May 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29767556/hydronephrosis-is-associated-with-elevated-plasmin-in-urine-in-pediatric-patients-and-rats-and-changes-in-ncc-and-%C3%AE-enac-abundance-in-rat-kidney
#7
Rikke Zachar, Ammar Al-Mashhadi, Henrik Dimke, Per Svenningsen, Boye L Jensen, Mattias Carlström
Obstruction of urine flow at the level of the pelvo-ureteric junction (UPJO) and subsequent development of hydronephrosis is one of the most common congenital renal malformations. UPJO is associated with development of salt-sensitive hypertension, which is set by the obstructed kidney, and with a stimulated renin-angiotensin-aldosterone system (RAAS) in rodent models. This study aimed at investigating the hypothesis that i) in pediatric patients with UPJO the RAAS is activated prior to surgical relief of the obstruction; ii) in rats with UPJO the RAAS activation is reflected by increased abundance of renal aldosterone-stimulated Na+ transporters; and iii) the injured UPJO kidney allows aberrant filtration of plasminogen leading to proteolytic activation of the epithelial sodium channel gamma subunit (γ-ENaC)...
May 16, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29767455/ureterocalicostomy-with-lower-pole-nephrectomy-in-a-renal-transplant-a-case-report
#8
Rafael Haddad Astolfi, Guilherme Alonso Daud Patavino, Claudia Felipe Rosso, Helio Tedesco Silva Junior, Jose Osmar Medina Pestana, Alex Elton Meller, Wilson Aguiar
As the number of kidney transplants continues to rise, so does the number and complexities of surgical-related complications, which may be associated with increased morbidity and potentially graft loss. Ureteral stenosis, the most prevalent urological complication, may require diverse techniques for surgical correction depending on several recipient and graft abnormalities. Here we report the surgical and clinical outcomes of a 62-year-old man with a postransplant pyeloureterostomy stricture successfully treated with ureterocalycostomy after a lower pole nephrectomy...
May 16, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29767451/feline-ureteral-obstructions-part-1-medical-management
#9
REVIEW
D L Clarke
Feline ureteral obstructions are an increasingly recognised and challenging diagnostic and management problem. Many cats with ureteral obstructions are critically ill at the time of diagnosis, especially if there is dysfunction of the contralateral kidney. They may present with varying severities of acute kidney injury, electrolyte disturbances, and may have comorbidities such as heart disease that complicate perioperative and long-term management. Medical management, which may consist of rehydration and restoration of intravascular volume with intravenous fluid therapy, osmotic diuresis, ureteral muscle relaxation, and antimicrobials for infection, is important in feline ureteral obstruction patients...
May 16, 2018: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/29766318/a-randomized-controlled-trial-evaluating-sildenafil-citrate-in-relieving-ureteral-stent-related-symptoms
#10
Mohamed Tharwat, Mohamed M Elsaadany, Ahmed M Lashin, Ahmed R El-Nahas
PURPOSE: To evaluate the role of sildenafil in relieving ureteral stent symptoms. PATIENTS AND METHODS: A randomized controlled trial was conducted between March 2014 and November 2016. It included adult men who underwent unilateral ureteric stent after ureteroscopy. Patients who were taking PDE5-Is, alpha-blockers or anticholinergics, had contraindication to sildenafil or developed postoperative complications were not included. Eligible patients were randomized using sealed closed envelops to one of two groups (S and C)...
May 15, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29764771/external-stent-in-laparoscopic-pyeloplasty-the-k-wire-technique
#11
A Upasani, A Paul, A Cherian
The majority of surgeons leave internal stents following laparoscopic pyeloplasty, which necessitates a second anaesthetic for removal. A novel technique of placing external nephro-ureteric stents, thus obviating a second procedure for retrieval, is shown in this video bank. As demonstrated in the video, a Kirschner wire (K-wire) is used to thread the stent in place. Although, there are few reports of using externalised stents in laparoscopic pyeloplasty, it is believed that this technique has not been previously described...
April 26, 2018: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29761687/emergency-extracorporeal-shockwave-lithotripsy-eswl-as-opposed-to-delayed-swl-dswl-for-the-treatment-of-acute-renal-colic-due-to-obstructive-ureteral-stone-a-prospective-randomized-trial
#12
Stefano Bucci, Paolo Umari, Michele Rizzo, Nicola Pavan, Giovanni Liguori, Fabio Barbone, Carlo Trombetta
BACKGROUND: To assess the efficacy of emergency extracorporeal shockwave lithotripsy (eSWL) as first-line treatment in patients with acute colic due to obstructive ureteral stone. METHODS: 74 patients were randomized to emergency SWL within 12 hours (eSWL group) and deferred SWL later than 3 days (dSWL group). Follow-up included ultrasound, KUB (Kidney-Ureter-Bladder) radiography and CT (computed tomography) scan at 24 hours, 7 days, 1 and 3 months from the treatment...
May 14, 2018: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/29761227/outcome-of-flexible-ureteroscopy-for-renal-stone-with-overnight-ureteral-catheterization-a-propensity-score-matching-analysis
#13
Mitsuru Komeya, Kimitsugu Usui, Takuo Asai, Takehiko Ogawa, Masataka Taguri, Koshi Kataoka, Masahiro Yao, Junichi Matsuzaki
PURPOSE: To evaluate the influence of overnight ureteral catheterization and determine if routine long-term post-stenting can be avoided in flexible ureterorenoscopy (fURS) procedure for kidney stone. METHODS: Three hundred ninety-three patients who underwent single fURS for kidney stone between January 2013 and June 2016 at a single institute were retrospectively analyzed. The stone-free (SF) and perioperative complication rates in patients with routine long-term post-stenting after fURS (long-term stent group) were compared with those of patients with overnight ureteral catheterization (short-term stent group)...
May 14, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29759484/runt-related-transcription-factor-1-runx1-promotes-tgf-%C3%AE-induced-renal-tubular-epithelial-to-mesenchymal-transition-emt-and-renal-fibrosis-through-the-pi3k-subunit-p110%C3%AE
#14
Tong Zhou, Maocai Luo, Wei Cai, Siyuan Zhou, Danying Feng, Chundi Xu, Hongyan Wang
Renal fibrosis is widely considered a common mechanism leading to end-stage renal failure. Epithelial-to-mesenchymal transition (EMT) plays important roles in the pathogenesis of renal fibrosis. Runt-related transcription factor 1(RUNX1) plays a vital role in hematopoiesis via Endothelial-to-Hematopoietic Transition (EHT), a process that is conceptually similar to EMT, but its role in EMT and renal fibrosis is unclear. Here, we demonstrate that RUNX1 is overexpressed in the processes of TGF-β-induced partial EMT and renal fibrosis and that the expression level of RUNX1 is SMAD3-dependent...
May 11, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29756043/surgical-management-of-nephrolithiasis-in-the-bottlenose-dolphin-collaborations-between-the-urologist-and-veterinarian
#15
Roger L Sur, Jenny M Meegan, Cynthia R Smith, Todd Schmitt, James L'Esperance, Dean Hendrikson, Jason R Woo
Background: Cohorts of bottlenose ( Tursiops truncatus ) dolphins are at significant risk for nephrolithiasis development. However, effective surgical treatment has been limited due to absence of literature and also familiarity by both veterinarians and urologists. Recently a joint veterinarian and urology team were called to treat local bottlenose dolphins in San Diego, CA, and they performed several cases. The fund of knowledge from these cases is presented for future providers who may be asked to surgically treat these animals...
2018: Journal of Endourology Case Reports
https://www.readbyqxmd.com/read/29752980/evaluation-of-a-ureteral-catheter-coating-by-means-of-a-bioencrustation-in-vitro-model
#16
M Frant, E Dayyoub, U Bakowsky, K Liefeith
Biomaterials for applications in the urinary tract are challenged with both biofilm formation and encrustation, two highly interconnected processes. While great effort has been achieved developing promising materials there is only a limited choice of sophisticated in vitro models that are available to analyse the performance of biomaterials prior to performing delicate and expensive in vivo studies. In this study we present a complex BioEncrustation model that imitates both the processes of multi-species biofilm formation and encrustation in vitro...
May 9, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29752769/systematic-review-on-ureteral-access-sheaths-facts-and-myths
#17
REVIEW
Vincent De Coninck, Etienne Xavier Keller, María Rodríguez-Monsalve, Marie Audouin, Steeve Doizi, Olivier Traxer
OBJECTIVES: To review literature on all available ureteral access sheaths (UASs) with their indications, limitations, risks, advantages and disadvantages in current modern endourological practice. PATIENTS AND METHODS: Two authors searched Medline, Scopus, Embase and Web of Science databases to identify studies on UASs published in English. No time period restriction was applied. All original articles reporting about outcomes or innovations were included. Additional articles identified through references lists were also included...
May 11, 2018: BJU International
https://www.readbyqxmd.com/read/29751025/laparoscopic-yang-monti-ureteral-reconstruction-in-children
#18
Dehong Liu, Huixia Zhou, Xuemei Hao, Hualin Cao, Lifei Ma, Xiaoguang Zhou, Tian Tao, Wei Cheng, Zhichun Feng
OBJECTIVE: To investigate the clinical outcome of surgical treatment for long ureteral defect in children, we evaluated our experience of managing six children with the long defect utilizing laparoscopic ureteral reconstruction technique using Yang-Monti technique. MATERIALS AND METHODS: Six children with long ureteral defect who underwent laparoscopic Yang-Monti ureteral reconstruction between January 2013 and March 2016 were reviewed. The diagnosis and outcomes of long ureteral defects were reviewed based on clinical and imaging data...
May 8, 2018: Urology
https://www.readbyqxmd.com/read/29749461/upregulation-of-allograft-inflammatory-factor%C3%A2-1-expression-and-secretion-by-macrophages-stimulated-with-aldosterone-promotes-renal-fibroblasts-to-a-profibrotic-phenotype
#19
Yushu Li, Xingzhi Wang, Lei Zhang, Xueying Yuan, Jianbing Hao, Jie Ni, Lirong Hao
Macrophages have been identified as a key cell type in the pathogenesis of renal interstitial fibrosis (RIF). However, the mechanism through which macrophages drive fibrosis remains unclear. The current study focuses on the effects and possible underlying mechanism of allograft inflammatory factor‑1 (AIF‑1), an inflammation‑responsive scaffold protein expressed and secreted by macrophages, in promoting fibroblasts to a profibrotic phenotype. In vivo experiments indicated that AIF‑1, CD68 and α‑smooth muscle actin (α‑SMA) were upregulated in kidney tissues of mice subjected to unilateral ureteric obstruction, while their expressions were inhibited by an aldosterone receptor antagonist, spironolactone...
May 10, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29748123/vesicoscopic-cross-trigonal-ureteral-reimplantation-high-success-rate-for-elimination-of-primary-reflux
#20
V R Jayanthi
INTRODUCTION: Open ureteral reimplantation (UR) is the gold standard for the surgical management of vesicoureteral reflux (VUR). There have been increasing reports on robot-assisted UR, but this approach remains controversial due to reports suggesting increased complications and reduced success compared with open repair. This study presented extensive experience with vesicoscopic ureteral reimplantation (VR) for primary reflux. In this procedure, cross-trigonal reimplantation was performed in a manner analogous to open repair under carbon dioxide 'pneumovesicum'...
April 28, 2018: Journal of Pediatric Urology
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