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Likelihood ratios

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https://www.readbyqxmd.com/read/28926826/a-low-cerebroplacental-ratio-at-20-24-weeks-of-gestation-can-predict-reduced-fetal-size-later-in-pregnancy-or-at-birth
#1
Edgar Hernandez-Andrade, Eli Maymon, Offer Erez, Homam Saker, Suchaya Luewan, Maynor Garcia, Hyunyoung Ahn, Adi L Tarca, Bogdan Done, Steven J Korzeniewski, Sonia S Hassan, Roberto Romero
AIM: To determine whether Doppler evaluation at 20-24 weeks of gestation can predict reduced fetal size later in pregnancy or at birth. METHODS: Fetal biometry and Doppler velocimetry were performed in 2,986 women with a singleton pregnancy at 20-24 weeks of gestation. Predictive performances of the umbilical artery pulsatility index (UA-PI) or the mean uterine artery pulsatility index (UtA-PI) >95th percentile, middle cerebral artery pulsatility index, or cerebroplacental ratio (CPR) <5th percentile for early small for gestational age (SGA; <34 weeks of gestation), late SGA (≥34 weeks of gestation), or SGA at birth (birthweight <10th percentile) were analyzed...
September 20, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28926500/occipital-lobe-and-posterior-cingulate-perfusion-in-the-prediction-of-dementia-with-lewy-body-pathology-in-a-clinical-sample
#2
Angus M J Prosser, Livia Tossici-Bolt, Christopher M Kipps
OBJECTIVE: The aim of this study was to investigate the diagnostic value of occipital lobe and posterior cingulate perfusion in predicting dopamine transporter imaging outcome using a quantitative measure of analysis. PATIENTS AND METHODS: In total, 99 patients with cognitive complaints who had undergone both technetium-99m-hexamethylpropyleneamine oxime single-photon emission computed tomography (Tc-HMPAO SPECT) and I ioflupane (I-FP-CIT also called DaTSCAN) imaging in a dementia diagnostic center were analyzed...
September 18, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28926136/serum-hotair-and-gas5-levels-as-predictors-of-survival-in-patients-with-glioblastoma
#3
Jie Shen, Tiffany R Hodges, Renduo Song, Ye Gong, George A Calin, Amy B Heimberger, Hua Zhao
BACKGROUND: Circulating long non-coding RNAs (lncRNAs) are a new class of cancer biomarkers. However, their significance in predicting outcomes in glioblastoma patients is unclear. METHODS: We measured the levels of six known oncogenic lncRNAs -- CRNDE, GAS5, H19, HOTAIR, MALAT1 and TUG1 in serum samples from 106 patients with primary glioblastoma and analyzed their association with outcomes. RESULTS: High levels of HOTAIR were associated with increased likelihood of death (adjusted hazard ratio [HR] = 2...
September 19, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/28924583/screening-for-primary-aldosteronism-using-the-newly-developed-ids-isys%C3%A2-automated-assay-system
#4
P M O'Shea, T P Griffin, G A Browne, N Gallagher, J J Brady, M C Dennedy, M Bell, D Wall, M Fitzgibbon
BACKGROUND: The recommended approach to screening for primary aldosteronism (PA) in at-risk populations is to determine the ratio of aldosterone concentration (serum (SAC)/plasma (PAC)) to renin measured in plasma as activity (PRA) or concentration (DRC). However, lack of assay standardisation mandates the need for method-specific decision thresholds and clinical validation in the local population. AIM: The study objective was to establish method-specific aldosterone: renin ratio (ARR) cut-offs for PA in men and women using the IDS-iSYS® assay system (IDS plc)...
April 2017: Pract Lab Med
https://www.readbyqxmd.com/read/28924253/quantitative-trait-loci-responsible-for-sharp-eyespot-resistance-in-common-wheat-ci12633
#5
Xujiang Wu, Kai Cheng, Renhui Zhao, Shujiang Zang, Tongde Bie, Zhengning Jiang, Ronglin Wu, Derong Gao, Boqiao Zhang
Sharp eyespot is a major fungal disease of wheat caused by Rhizoctonia cerealis in cool and humid environments worldwide. In this study, 224 single seed descent derived F13, F14 and F15 recombinant inbred lines (RILs) from the cross between CI12633 (a resistant cultivar) and Yangmai 9 (a susceptible cultivar) were assessed for sharp eyespot resistance (R.cerealis isolate R0301) in field and greenhouse conditions in three growing seasons. Different agronomic characteristics were also evaluated in the field with no disease infection...
September 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28923844/red-flag-screening-for-low-back-pain-nothing-to-see-here-move-along-a-narrative-review
#6
REVIEW
Chad E Cook, Steven Z George, Michael P Reiman
Screening for red flags in individuals with low back pain (LBP) has been a historical hallmark of musculoskeletal management. Red flag screening is endorsed by most LBP clinical practice guidelines, despite a lack of support for their diagnostic capacity. We share four major reasons why red flag screening is not consistent with best practice in LBP management: (1) clinicians do not actually screen for red flags, they manage the findings; (2) red flag symptomology negates the utility of clinical findings; (3) the tests lack the negative likelihood ratio to serve as a screen; and (4) clinical practice guidelines do not include specific processes that aid decision-making...
September 18, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28923070/univariate-and-multivariate-spatial-models-of-health-facility-utilisation-for-childhood-fevers-in-an-area-on-the-coast-of-kenya
#7
Paul O Ouma, Nathan O Agutu, Robert W Snow, Abdisalan M Noor
BACKGROUND: Precise quantification of health service utilisation is important for the estimation of disease burden and allocation of health resources. Current approaches to mapping health facility utilisation rely on spatial accessibility alone as the predictor. However, other spatially varying social, demographic and economic factors may affect the use of health services. The exclusion of these factors can lead to the inaccurate estimation of health facility utilisation. Here, we compare the accuracy of a univariate spatial model, developed only from estimated travel time, to a multivariate model that also includes relevant social, demographic and economic factors...
September 18, 2017: International Journal of Health Geographics
https://www.readbyqxmd.com/read/28922780/use-of-alternative-medicine-for-cancer-and-its-impact-on-survival
#8
Skyler B Johnson, Henry S Park, Cary P Gross, James B Yu
There is limited available information on patterns of utilization and efficacy of alternative medicine (AM) for patients with cancer. We identified 281 patients with nonmetastatic breast, prostate, lung, or colorectal cancer who chose AM, administered as sole anticancer treatment among patients who did not receive conventional cancer treatment (CCT), defined as chemotherapy, radiotherapy, surgery, and/or hormone therapy. Independent covariates on multivariable logistic regression associated with increased likelihood of AM use included breast or lung cancer, higher socioeconomic status, Intermountain West or Pacific location, stage II or III disease, and low comorbidity score...
January 1, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28922692/phosphodiesterase-4-inhibitors-for-chronic-obstructive-pulmonary-disease
#9
REVIEW
Jimmy Chong, Bonnie Leung, Phillippa Poole
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is associated with cough, sputum production or dyspnoea and a reduction in lung function, quality of life and life expectancy. Apart from smoking cessation, there are no other treatments that slow lung function decline. Roflumilast and cilomilast are oral phosphodiesterase 4 (PDE4) inhibitors proposed to reduce the airway inflammation and bronchoconstriction seen in COPD. This is an update of a Cochrane review first published in 2011 and updated in 2013...
September 19, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28919460/a-likelihood-based-approach-to-p-value-interpretation-provided-a-novel-plausible-and-clinically-useful-research-study-metric
#10
Nicholas G Adams, Gerard O'Reilly
OBJECTIVES: Interpretation of clinical research findings using the paradigm of null hypothesis significance testing has a number of limitations. These include arbitrary dichotomization of results, lack of incorporation of study power and prior probability, and the confusing use of conditional probability. This study aimed to describe a novel method of P-value interpretation that would address these limitations. STUDY SETTING AND DESIGN: Published clinical research was re-interpreted using the delta likelihood ratio...
September 14, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28919232/the-accuracy-of-shape-irregularity-and-density-heterogeneity-on-non-contrast-computed-tomography-for-predicting-hematoma-expansion-in-spontaneous-intracerebral-hemorrhage-a-systematic-review-and-meta-analysis
#11
Zhiyuan Yu, Jun Zheng, Zhao Xu, Mou Li, Xiaoze Wang, Sen Lin, Hao Li, Chao You
OBJECTIVE: This systematic review and meta-analysis was aimed to evaluate the predictive values of shape irregularity and density heterogeneity of hematoma on non-contrast computed tomography (NCCT) for hematoma expansion (HE). METHODS: A literature search was performed in PubMed, EMBASE, SCOPUS, Web of Science and Cochrane Library. Studies about predictive values of shape regularity or density heterogeneity of hematoma on NCCT for HE in sICH were included. Meta-analysis was performed to pool the data...
September 12, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28919182/population-based-study-of-the-incidence-and-survival-for-intraductal-carcinoma-of-the-prostate
#12
Brian F Dinerman, Francesca Khani, Ron Golan, Adrien N Bernstein, Michael F Cosiano, Daniel J Margolis, Jim C Hu
PURPOSE: The degree to which intraductal carcinoma of the prostate (IDC-P) affects clinical course remains poorly understood owing to small sample sizes from single-center studies. We sought to determine prognostic factors and outcomes associated with IDC-P in radical prostatectomy (RP) specimens. MATERIALS AND METHODS: This is a retrospective study of RP during 2004 to 2013 using Surveillance, Epidemiology, and End Results to compare IDC-P with non-IDC-P. The effect of IDC-P on overall and disease-specific survival was assessed using Cox regression with a median follow-up of 4...
September 14, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28918414/a-protocol-of-a-cross-sectional-study-evaluating-an-online-tool-for-early-career-peer-reviewers-assessing-reports-of-randomised-controlled-trials
#13
Anthony Chauvin, David Moher, Doug Altman, David L Schriger, Sabina Alam, Sally Hopewell, Daniel R Shanahan, Alessandro Recchioni, Philippe Ravaud, Isabelle Boutron
INTRODUCTION: Systematic reviews evaluating the impact of interventions to improve the quality of peer review for biomedical publications highlighted that interventions were limited and have little impact. This study aims to compare the accuracy of early career peer reviewers who use an innovative online tool to the usual peer reviewer process in evaluating the completeness of reporting and switched primary outcomes in completed reports. METHODS AND ANALYSIS: This is a cross-sectional study of individual two-arm parallel-group randomised controlled trials (RCTs) published in the BioMed Central series medical journals, BMJ, BMJ Open and Annals of Emergency Medicine and indexed with the publication type 'Randomised Controlled Trial'...
September 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/28917240/snack-and-beverage-consumption-and-preferences-in-a-sample-of-chinese-children-are-they-influenced-by-advertising
#14
Peng Liu, Yang Yu, Lesley King, Mu Li
BACKGROUND AND OBJECTIVES: The consumption of unhealthy snack and beverages can lead to childhood obesity, which has become a major concern globally. Television food advertisements may influence children's snack and beverages preferences. This article aims to explore children's snack and beverage consumption habits; examine the extent of television advertising for non-core (energy-dense, nutrient poor) snack and beverages; and assess the influence of television advertising on children's snack and beverages preferences in Harbin, China...
2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28916590/us-emergency-department-trends-in-imaging-for-pediatric-nontraumatic-abdominal-pain
#15
Lauren M Niles, Monika K Goyal, Gia M Badolato, James M Chamberlain, Joanna S Cohen
OBJECTIVES: To describe national emergency department (ED) trends in computed tomography (CT) and ultrasound imaging for the evaluation of pediatric nontraumatic abdominal pain from 2007 through 2014. METHODS: We used data from the National Hospital Ambulatory Medical Care Survey to measure trends in CT and ultrasound use among children with nontraumatic abdominal pain. We performed multivariable logistic regression to measure the strength of the association of ED type (pediatric versus general ED) with CT and ultrasound use adjusting for potential confounding variables...
September 15, 2017: Pediatrics
https://www.readbyqxmd.com/read/28916424/predictors-of-epinephrine-dispensing-and-allergy-follow-up-after-emergency-department-visit-for-anaphylaxis
#16
Megan Motosue, M Fernanda Bellolio, Holly K Van Houten, Nilay D Shah, Ronna L Campbell
BACKGROUND: National guidelines recommend that patients with anaphylaxis be prescribed an epinephrine auto-injector (EAI) and referred to an allergy/immunology (A/I) specialist. OBJECTIVE: To evaluate guideline concordance and identify predictors of EAI dispensing and A/I follow-up in patients with anaphylaxis treated in the emergency department (ED). METHODS: We identified patients seen in the ED for anaphylaxis from 2010 through 2014 from an administrative claims database using an expanded International Classification of Diseases, Ninth Revision, Clinical Modification diagnosis code algorithm...
September 12, 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28915773/does-motor-development-in-infancy-predict-spinal-pain-in-later-childhood-a-cohort-study
#17
Steven J Kamper, Christopher M Williams, Lise Hestbaek
Study Design Longitudinal cohort study. Background Spinal pain is responsible for a huge personal and societal burden but the aetiology remains unclear. Deficits in motor control have been implicated with spinal pain in adults, and delayed motor development is associated with a range of health problems and risks in children. Objectives To assess whether there is an independent relationship between the age at which infants first sit and walk without support, and spinal pain at age 11 years. Methods Data from the Danish National Birth Cohort were analysed...
September 15, 2017: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/28915317/the-theoretical-reliability-of-pcr-based-fish-viral-diagnostic-methods-is-critically-affected-when-they-are-applied-to-fish-populations-with-low-prevalence-and-virus-loads
#18
C P Dopazo, P Moreno, J G Olveira, J J Borrego
AIMS: The reliability of PCR techniques is an important issue in viral diagnosis, and it is even crucial when they must be applied for detection of viruses in asymptomatic carriers. The problems will arise when the aim is to study fish wild populations, where the viral loads and prevalence values are extremely low. We have evaluated several PCR procedures employed by two laboratories for monitoring fish captured in several oceanographic campaigns performed in the Gulf of Cádiz. METHODS AND RESULTS: To evaluate the reliability of different diagnostics test used, we have re-analyzed fish samples that had been previously subjected to diagnosis for a surveillance of viruses performed in 2010-2011 in wild fish populations...
September 15, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28915303/prevalence-of-functional-dentition-in-a-group-of-mexican-adult-males
#19
Mirna Minaya-Sánchez, Carlo Eduardo Medina-Solís, Juan Fernando Casanova-Rosado, Ana Alicia Vallejos-Sánchez, Alejandro José Casanova-Rosado, María de Lourdes Márquez-Corona, Martha Mendoza-Rodríguez, Gerardo Maupomé
OBJECTIVE: To determine the prevalence of functional dentition and associated periodontal variables in a sample of Mexican adult males. METHODS: A cross-sectional study of 161 policemen in Campeche, Mexico, was carried out. A clinical examination using an electronic probe was used to collect variables (dental plaque, periodontal pockets, gingival recession, suppuration, and bleeding on probing) on 6 periodontal sites (a maximum of 168 sites, excluding third molars)...
September 2017: Puerto Rico Health Sciences Journal
https://www.readbyqxmd.com/read/28915153/associations-of-early-opioid-use-with-patient-reported-outcomes-and-healthcare-utilization-among-older-adults-with-low-back-pain
#20
Laura S Gold, Ryan N Hansen, Andrew L Avins, Zoya Bauer, Bryan A Comstock, Richard A Deyo, Patrick J Heagerty, Sean D Rundell, Pradeep Suri, Judith A Turner, Jeffrey G Jarvik
OBJECTIVES: To compare outcomes and healthcare utilization of older patients who did versus did not fill opioid prescriptions within 90 days of initiating care for low back pain. MATERIALS AND METHODS: For patients ≥65 years with new back pain visits, we used propensity scores to match those who filled no opioid prescriptions to those who filled ≥2 opioid prescriptions within 90 days (and the first opioid prescription within 30 d) of the index visit. Over 24 months, we examined patient-reported outcomes, healthcare utilization, and subsequent opioid prescription fills...
September 14, 2017: Clinical Journal of Pain
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