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https://www.readbyqxmd.com/read/29337703/new-antibiotics-for-ventilator-associated-pneumonia
#1
Matteo Bassetti, Antionio Vena, Nadia Castaldo, Elda Righi, Maddalena Peghin
PURPOSE OF REVIEW: Ventilator-associated pneumonia (VAP) caused by multidrug-resistant (MDR) bacteria represents a global emerging problem. Delayed prescription of an adequate treatment for VAP has been associated with higher morbidity and mortality. New molecules have been developed to face the need of compounds that are active against resistant Gram-positive and Gram-negative pathogens. The aim of this review is to summarize the current scenario of new therapeutic options for the treatment of VAP...
January 13, 2018: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/29327810/nebulized-hypertonic-saline-in-infants-hospitalized-with-moderately-severe-bronchiolitis-due-to-rsv-infection-a-multicenter-randomized-controlled-trial
#2
Yoshihiko Morikawa, Masaru Miura, Megumi Y Furuhata, Saeko Morino, Tae Omori, Masahiro Otsuka, Michiko Chiga, Toshimasa Obonai, Hiroshi Hataya, Tetsuji Kaneko, Kenji Ishikura, Masataka Honda, Yukihiro Hasegawa
INTRODUCTION: The efficacy of nebulized hypertonic saline (HS) therapy for shortening hospital length of stay (LOS) or improving bronchiolitic symptoms remains controversial. Most studies enrolled small numbers of subjects and did not consider the role of respiratory syncytial virus (RSV), the most common cause of acute bronchiolitis. Our aim was to evaluate the efficacy and safety of nebulized HS therapy for acute bronchiolitis due to RSV in moderately ill hospitalized infants. MATERIALS AND METHODS: This was an open-label, multicenter, randomized controlled trial comparing a nebulized HS treatment group with a normal saline (NS) group...
January 12, 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29325508/mesh-nebulizers-have-become-the-first-choice-for-new-nebulized-pharmaceutical-drug-developments
#3
John N Pritchard, Ross Hm Hatley, John Denyer, Dirk von Hollen
In the 24 years since first being marketed, the mesh nebulizer has been developed by five main manufacturers into a viable solution for the delivery of high-value nebulized drugs. Mesh nebulizers provide increased portability, convenience and energy efficiency along with similar lung deposition and increased ease of use compared with jet nebulizers. An analysis of EU and US clinical trial databases has shown that mesh nebulizers are now preferred over jet nebulizers for clinical trials sponsored by pharmaceutical companies...
February 2018: Therapeutic Delivery
https://www.readbyqxmd.com/read/29321923/idiopathic-pulmonary-vein-thrombosis
#4
Timothy J Barreiro, Venkateswara K Kollipara, David J Gemmel
Idiopathic pulmonary vein thrombosis (PVT) is a rare disease which is likely under-diagnosed because of nebulous presentations. Accurate diagnosis is essential to prevent complications.
January 2018: Respirology Case Reports
https://www.readbyqxmd.com/read/29321114/nebulized-ketamine-to-avoid-mechanical-ventilation-in-a-pediatric-patient-with-severe-asthma-exacerbation
#5
Abdelghafour Elkoundi, Aziza Bentalha, Alae El Koraichi, Salma Ech-Cherif El Kettani
Asthma is a major cause of morbidity and mortality despite advances in outpatient treatment. Sometimes, children fail to respond to standard treatment and can potentially require mechanical ventilation. We describe a case of a 26-month-old girl with a severe asthma exacerbation successfully managed by ketamine administration via nebulization route that permitted to avoid mechanical ventilation. Nebulized ketamine might be a reasonable option to avoid mechanical ventilation in children who fail to respond to standard treatment of severe asthma exacerbation...
January 6, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29319329/a-case-of-nebulized-naloxone-use-with-confirmatory-serum-naloxone-concentrations
#6
Faisal S Minhaj, Rachel F Schult, Aaron Fields, Timothy J Wiegand
No abstract text is available yet for this article.
January 1, 2018: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29318460/nebulization-of-antimicrobial-agents-in-mechanically-ventilated-adults-in-2017-an-international-cross-sectional-survey
#7
Joana Alves, Emine Alp, Despoina Koulenti, Zhongheng Zhang, Stephan Ehrmann, Stijn Blot, Matteo Bassetti, Andrew Conway-Morris, Rosa Reina, Enrique Teran, Candela Sole-Lleonart, Maria Ruiz-Rodríguez, Jordi Rello
2017 ESCMID practice guidelines reported safety concerns and weak evidence of benefit supporting use of aerosolized antibiotics in mechanically ventilated patients. Our primary goal was to assess current patterns of aerosolized antibiotic prescription in mechanically ventilated patients. A sequential global survey was performed prior to the release of the ESCMID guidelines, from the 1st of February to the 30th of April 2017, using an electronic platform. Responses were analyzed comparing geographical regions...
January 9, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29310221/determination-of-the-structure-and-composition-of-au-ag-bimetallic-spherical-nanoparticles-using-single-particle-icp-ms-measurements-performed-with-normal-and-high-temporal-resolution
#8
Albert Kéri, Ildikó Kálomista, Ditta Ungor, Ádám Bélteki, Edit Csapó, Imre Dékány, Thomas Prohaska, Gábor Galbács
In this study, the information that can be obtained by combining normal and high resolution single particle ICP-MS (spICP-MS) measurements for spherical bimetallic nanoparticles (BNPs) was assessed. One commercial certified core-shell Au-Ag nanoparticle and three newly synthesized and fully characterized homogenous alloy Au-Ag nanoparticle batches of different composition were used in the experiments as BNP samples. By scrutinizing the high resolution spICP-MS signal time profiles, it was revealed that the width of the signal peak linearly correlates with the diameter of nanoparticles...
March 1, 2018: Talanta
https://www.readbyqxmd.com/read/29281786/rapid-detection-of-volatile-organic-compounds-in-a-drop-urine-by-ultrasonic-nebulization-extraction-proton-transfer-reaction-mass-spectrometry
#9
Xue Zou, Yan Lu, Lei Xia, Yating Zhang, Aiyue Li, Hongmei Wang, Chaoqun Huang, Chengyin Shen, Yannan Chu
Detection of volatile organic compounds (VOCs) in human urine has potential application value in screening for disease and toxic exposure. However, the current technologies are too slow to get the concentration of VOCs in fresh urine. In this study, we developed a novel ultrasonic nebulization extraction proton transfer reaction mass spectrometry (UNE-PTR-MS) technology. The urinary VOCs can be rapidly extracted to gaseous VOCs using the UNE system and then delivered using a carrier gas to the PTR-MS instrument for rapid detection...
December 27, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29277689/aerosol-delivery-during-spontaneous-breathing-with-different-types-of-nebulizers-in-vitro-ex-vivo-models-evaluation
#10
Hui-Ling Lin, Tien-Pei Fang, Hui-Sun Cho, Gwo-Hwa Wan, Meng-Jer Hsieh, James B Fink
BACKGROUND: Nebulizers for spontaneous breathing have been evaluated through different study designs. There are limitations in simulated bench models related to patient and nebulizer factors. The aim of this study was to determine the correlation of inhaled drug mass between in vitro and ex vivo studies by testing aerosol deposition of various types of nebulizers. METHODS: Ten healthy subjects were recruited to receive aerosol therapy with five nebulizers in random order: 1) a jet nebulizer (JN); 2) a breath-enhanced nebulizer (BEN); 3) a manually triggered nebulizer (MTN), 4) a breath-actuated nebulizer (BAN), and 5) a vibrating mesh nebulizer (VMN) with valved-adapter...
December 19, 2017: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29276868/rational-drug-use-for-acute-bronchiolitis-in-emergency-care
#11
Metin Uysalol, Fatih Haşlak, Zeynep Güneş Özünal, Hayriye Vehid, Nedret Uzel
Uysalol M, Haşlak F, Özünal ZG, Vehid H, Uzel N. Rational drug use for acute bronchiolitis in emergency care. Turk J Pediatr 2017; 59: 155-161. Despite the large variety of inhaled treatment options of acute bronchiolitis, there is no generally agreed treatment regime. This study aimed to determine the most appropriate treatment option. This was a double-blind randomized prospective clinical trial and has been performed in emergency department. The mean age of the 378 infants included in the study was 7...
2017: Turkish Journal of Pediatrics
https://www.readbyqxmd.com/read/29276307/in-vitro-assessment-of-small-charged-pharmaceutical-aerosols-in-a-model-of-a-ventilated-neonate
#12
Landon Holbrook, Michael Hindle, P Worth Longest
Aerosolized medications may benefit infants receiving mechanical ventilation; however, the lung delivery efficiency of these aerosols is unacceptably low. In vitro experiments were conducted to evaluate aerosol delivery through conventional and modified ventilation systems to the end of a 3mm endotracheal tube (ETT) under steady state and realistic cyclic flow conditions. System modifications were employed to investigate the use of small charged particles and included streamlined components, a reduction in nebulizer liquid flow rate, synchronization with inspiration, and implementation of a previously designed low-flow induction charger (LF-IC), which was further modified in this study...
August 2017: Journal of Aerosol Science
https://www.readbyqxmd.com/read/29276238/treatment-of-hypertriglyceridemia-induced-acute-pancreatitis-with-insulin-heparin-and-gemfibrozil-a-case-series
#13
Drayton A Hammond, Laura Finlay
Hypertriglyceridemia is the third most common worldwide cause of acute pancreatitis. Resolving the underlying etiology is imperative for optimal management. This is especially true with regard to hypertriglyceridemia, as this etiology may cause more severe acute pancreatitis and worse symptoms than other causes of the disease. Many pharmacological treatment options for hypertriglyceridemia-induced acute pancreatitis (HTGP) have been proposed; however, the safety and efficacy for specific treatment regimens remain nebulous...
November 2017: Hospital Pharmacy
https://www.readbyqxmd.com/read/29273349/nebulized-tranexamic-acid-as-a-therapeutic-alternative-in-pulmonary-hemorrhage
#14
Alejandro González-Castro, Juan Carlos Rodriguez-Borregán, Enrique Chicote, Patricia Escudero, Diego Ferrer
No abstract text is available yet for this article.
December 19, 2017: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/29261402/oral-versus-nasal-high-flow-bronchodilator-inhalation-in-chronic-obstructive-pulmonary-disease
#15
Jens Bräunlich, Hubert Wirtz
BACKGROUND: Nasal high flow (NHF) alters breathing patterns, stabilizes fraction of inspired oxygen (FiO2) during respiratory distress, helps to keep up hemostasis in the airways, and washes out the upper airways. Particularly the support of inspiratory flow and decrease in functional dead space are interesting mechanisms of action with regard to aerosol delivery. Several laboratory investigations have studied aerosol delivery via the nasal route by using NHF, whereas clinical benefits are poorly evaluated...
December 20, 2017: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/29260784/-the-role-of-local-immunotherapy-in-the-treatment-of-the-patients-presenting-with-virus-associated-allergic-rhinitis
#16
N S Tataurshchikova, B Sangidorzh
The objective of the present study was to evaluate the clinical effectiveness of intranasal immunotherapy with the use of сycloferon in the patients presenting with seasonal virus-associated allergic rhinitis during the period of pollination. The results of the treatment of 50 patients with virus-associated allergic rhinitis (i.e. those allergic to the sagebrush pollen) were analyzed. The patients were divided into two groups depending on the therapeutic modality being used. Those comprising the main group (21 patients) received immunotherapy with сycloferon in addition to allergen-specific immunotherapy (by sublingual administration)...
2017: Vestnik Otorinolaringologii
https://www.readbyqxmd.com/read/29260071/transient-anisocoria-in-a-patient-treated-with-nebulized-ipratropium-bromide
#17
Renato Pejic, Branka Klaric
Purpose: We present a case report of a 44-year old female patient with complicated pneumonia who developed anisocoria after treatment with inhaled ipratropium bromide. Discontinuation of ipratropium bromide treatment led to complete resolution of anisocoria. Observation: A 44-year old female patient was admitted to the Department of Pulmonology due to high body temperature (40.0 °C), coughing and general weakness. After a general examination and tests the patient was diagnosed with right-sided pneumonia...
September 2017: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29259642/ethnopharmacological-evaluation-of-breu-essential-oils-from-protium-species-administered-by-inhalation
#18
Eduardo Rodrigues da Silva, Danilo Ribeiro de Oliveira, Patrícia Dias Fernandes, Humberto Ribeiro Bizzo, Suzana Guimarães Leitão
Background: Breu is an aromatic oleoresin which has been used by Amazonian traditional communities as a remedy for headaches and migraines by burning and inhaling the smoke produced during its combustion. This study evaluated the antinociceptive and sedative activities of formulations containing breu essential oils administered by inhalation. Methods: Five different formulations (A-E) containing breu essential oils were evaluated for their sedative and antinociceptive activities in mice...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29250438/faraday-waves-based-integrated-ultrasonic-micro-droplet-generator-and-applications
#19
Chen S Tsai, Rong W Mao, Shirley C Tsai, Kaveh Shahverdi, Yun Zhu, Shih K Lin, Yu-Hsiang Hsu, Gerry Boss, Matt Brenner, Sari Mahon, Gerald C Smaldone
An in-depth review on a new ultrasonic micro-droplet generator which utilizes megahertz (MHz) Faraday waves excited by silicon-based multiple Fourier horn ultrasonic nozzles (MFHUNs) and its potential applications is presented. The new droplet generator has demonstrated capability for producing micro droplets of controllable size and size distribution and desirable throughput at very low electrical drive power. For comparison, the serious deficiencies of current commercial droplet generators (nebulizers) and the other ultrasonic droplet generators explored in recent years are first discussed...
2017: Micromachines
https://www.readbyqxmd.com/read/29243015/relational-autonomy-in-the-care-of-the-vulnerable-health-care-professionals-reasoning-in-moral-case-deliberation-mcd
#20
Kaja Heidenreich, Anders Bremer, Lars Johan Materstvedt, Ulf Tidefelt, Mia Svantesson
In Moral Case Deliberation (MCD), healthcare professionals discuss ethically difficult patient situations in their daily practice. There is a lack of knowledge regarding the content of MCD and there is a need to shed light on this ethical reflection in the midst of clinical practice. Thus, the aim of the study was to describe the content of healthcare professionals' moral reasoning during MCD. The design was qualitative and descriptive, and data consisted of 22 audio-recorded inter-professional MCDs, analysed with content analysis...
December 14, 2017: Medicine, Health Care, and Philosophy
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