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rhinosinusitis antibiotics

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https://www.readbyqxmd.com/read/29350509/measuring-overuse-with-electronic-health-records-data
#1
Thomas Isaac, Meredith B Rosenthal, Carrie H Colla, Nancy E Morden, Alexander J Mainor, Zhonghe Li, Kevin H Nguyen, Elizabeth A Kinsella, Thomas D Sequist
OBJECTIVES: To measure overuse of low-value care using electronic health record (EHR) data and manual chart review and to evaluate whether certain low-value services are better captured using EHR data. STUDY DESIGN: We implemented algorithms to extract performance on 13 Choosing Wisely-identified healthcare services using EHR data at a large physician practice group between 2011 and 2013. METHODS: We calculated rates of overuse using automated EHR extracts...
January 2018: American Journal of Managed Care
https://www.readbyqxmd.com/read/29336283/headaches-and-facial-pain-in-rhinology
#2
Asitha D L Jayawardena, Rakesh Chandra
"Sinus headache" is a common chief complaint that often leads patients to an otolaryngologist's office. Because facial pain may or may not be sinogenic in origin, the otolaryngologist should be equipped to evaluate and treat or to appropriately refer these patients. Analysis of current data indicates that the majority of patients who present with sinus headaches actually have migraines. Furthermore, the downstream effect of the cytokine cascade initiated in migraine physiology can cause rhinologic symptoms, including rhinorrhea, congestion, and lacrimation, which may also confound diagnosis...
January 1, 2018: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/29331046/prevalence-severity-and-risk-factors-for-acute-exacerbations-of-nasal-and-sinus-symptoms-by-chronic-rhinosinusitis-status
#3
Jordan R Kuiper, Annemarie G Hirsch, Karen Bandeen-Roche, Agnes S Sundaresan, Bruce K Tan, Robert P Schleimer, Robert C Kern, Walter F Stewart, Brian S Schwartz
BACKGROUND: Nasal and sinus symptoms (NSS) are common to many health conditions, including chronic rhinosinusitis (CRS). Few studies have investigated the occurrence and severity of, and risk factors for, acute exacerbations of NSS (AENSS) by CRS status (current, past, or never met European Position Paper on Rhinosinusitis [EPOS] criteria for CRS). METHODS: Four seasonal questionnaires were mailed to a stratified random sample of Geisinger primary care patients...
January 13, 2018: Allergy
https://www.readbyqxmd.com/read/29317801/is-there-a-conflict-between-general-practitioners-applying-guidelines-for-antibiotic-prescribing-and-including-their-patients-preferences
#4
Anne Em Brabers, Thamar Em Van Esch, Peter P Groenewegen, Karin Hek, Pé Mullenders, Liset Van Dijk, Judith D De Jong
Objectives: One perceived barrier to guideline adherence is the existence of conflicting patient preferences. We examined whether patient preferences influence the prescription of antibiotics in general practice, and how this affects guideline adherence. We hypothesized that preferences play a larger role in prescribing antibiotics if the guideline allows for preferences to be taken into account, ie, if prescribing antibiotics is an option which can be considered rather than a clear recommendation to prescribe or not...
2018: Patient Preference and Adherence
https://www.readbyqxmd.com/read/29316282/are-multiple-sinus-cultures-necessary-during-sinus-surgery-for-chronic-rhinosinusitis
#5
Craig Miller, Greg E Davis
BACKGROUND: Multiple cultures are commonly obtained from different sinuses where purulence is encountered during endoscopic sinus surgery (ESS). This brings into question the utility and necessity of obtaining multiple cultures. The purpose of this study was to evaluate if multiple cultures obtained during a single case is informative in finding additional pathogens or if it is a redundant, cost-increasing practice. We hypothesized that multiple sinus cultures are necessary to identify the pathogens responsible for an individual's sinus disease...
January 5, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29247803/staphylococcus-aureus-controls-interleukin-5-release-in-upper-airway-inflammation
#6
C Bachert, G Holtappels, M Merabishvili, T Meyer, A Murr, N Zhang, K Van Crombruggen, E Gevaert, U Völker, B M Bröker, M Vaneechoutte, F Schmidt
Staphylococcus aureus is a frequent colonizer of the upper airways in chronic rhinosinusitis with nasal polyps, but also resides intramucosally; it has been shown that secreted staphylococcal proteins such as enterotoxins and serine proteases induce the release of cytokines such as IL-5. We have analyzed nasal polyp tissue freshly obtained during routine surgery, which did or did not contain cultivatable S. aureus, to study spontaneous IL-5 production by nasal polyp tissue over 24 and 72h in tissue culture...
December 13, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/29240296/bacteriophage-effectively-kills-multidrug-resistant-staphylococcus-aureus-clinical-isolates-from-chronic-rhinosinusitis-patients
#7
Guimin Zhang, Yin Zhao, Sathish Paramasivan, Katharina Richter, Sandra Morales, Peter-John Wormald, Sarah Vreugde
BACKGROUND: Bacteriophage (phage) therapy has been proposed as an alternative to antibiotics. Phages have been shown to kill antibiotic resistant Staphylococcus aureus strains; however, it is unknown whether stress-induced antibiotic tolerance affects S. aureus susceptibility to phages. Our objective was to determine the effectiveness of 2 phages currently in clinical development, against antibiotic-resistant and induced antibiotic-tolerant clinical S. aureus isolates. METHODS: Antibiotic tolerant S...
December 14, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29106996/chronic-rhinosinusitis-endotypes-biomarkers-and-treatment-response
#8
Jose Gurrola, Larry Borish
It is increasingly recognized that chronic rhinosinusitis (CRS) comprises a spectrum of different diseases with distinct clinical presentations and pathogenic mechanisms. Defining the distinct phenotypes and endotypes of CRS impacts prognosis and most importantly is necessary as the basis for making therapeutic decisions. The need for individualized defining of pathogenic mechanisms prior to initiating therapy extends to virtually all therapeutic considerations. This is clearly crucial with antibiotics where, barring an influence from their off-target anti-inflammatory pharmacological effects, an understanding of the role of individual biome predicts likelihood of therapeutic benefit...
October 26, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29094889/chronic-rhinosinusitis
#9
REVIEW
Ahmad R Sedaghat
Chronic rhinosinusitis is an inflammatory disease of the paranasal sinuses that occurs in 1% to 5% of the U.S. POPULATION: It may significantly decrease quality of life. Chronic rhinosinusitis is defined by the presence of at least two out of four cardinal symptoms (i.e., facial pain/pressure, hyposmia/anosmia, nasal drainage, and nasal obstruction) for at least 12 consecutive weeks, in addition to objective evidence. Objective evidence of chronic rhinosinusitis may be obtained on physical examination (anterior rhinoscopy, endoscopy) or radiography, preferably from sinus computed tomography...
October 15, 2017: American Family Physician
https://www.readbyqxmd.com/read/29083529/evaluation-of-patient-nasal-saline-irrigation-practices-following-endoscopic-sinus-surgery
#10
Frederick Yoo, Elisabeth H Ference, Edward C Kuan, Jivianne T Lee, Marilene B Wang, Jeffrey D Suh
BACKGROUND: Functional endoscopic sinus surgery (FESS) is an effective treatment for chronic rhinosinusitis (CRS). Postoperative management strategies after FESS often vary from surgeon to surgeon. Recent data suggests that nasal saline irrigation following FESS is almost universally recommended; however, patient adherence has not been formally evaluated. The purpose of this study is to evaluate postoperative nasal irrigation practices and its effects on short-term outcomes in post-FESS patients...
January 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29070622/sepsis-ptosis-an-unusual-diagnosis
#11
Brooke Leigh Powell, Oliver Toby Charles Morgan
The authors present the case of a 19-year old man presenting to the emergency department with a 2-day history of left eye pain and ptosis, facial pain around the maxillae, coryza, headaches and fevers. He had a background of autism, mild learning disability, obsessive-compulsive disorder and asthma. Within the last month, his risperidone and sertraline doses had been increased. Basic observations and investigations suggested sepsis: tachypnoea, sinus tachycardia, fever and a raised white cell count and C reactive protein level...
October 25, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29018773/activity-of-bacteriophages-in-removing-biofilms-of-pseudomonas-aeruginosa-isolates-from-chronic-rhinosinusitis-patients
#12
Stephanie A Fong, Amanda Drilling, Sandra Morales, Marjolein E Cornet, Bradford A Woodworth, Wytske J Fokkens, Alkis J Psaltis, Sarah Vreugde, Peter-John Wormald
Introduction:Pseudomonas aeruginosa infections are prevalent amongst chronic rhinosinusitis (CRS) sufferers. Many P. aeruginosa strains form biofilms, leading to treatment failure. Lytic bacteriophages (phages) are viruses that infect, replicate within, and lyse bacteria, causing bacterial death. Aim: To assess the activity of a phage cocktail in eradicating biofilms of ex vivo P.aeruginosa isolates from CRS patients. Methods: P. aeruginosa isolates from CRS patients with and without cystic fibrosis (CF) across three continents were multi-locus sequence typed and tested for antibiotic resistance...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28992906/renal-amyloidosis-associated-with-kartagener-syndrome-in-a-dog
#13
Bartolo Celona, Chiara Crinò, Carmelo Bruno, Simona Di Pietro, Elisabetta Giudice
A 4-year-old cocker spaniel, male, of 12kg body weight was presented because of the onset of polyuria or polydipsia. From the first months of its life, the dog had exhibited constant serous to mucopurulent nasal discharge, productive cough, sneezing, reverse sneezing, otitis, and recurrent episodes of fever. The respiratory signs had been treated several times with antibiotics, without ever achieving a complete resolution. Clinical examination revealed normal rectal temperature (38.3°C), increased respiratory rate (40breaths/min), a copious mucous nasal discharge and right deviation of the heart apex beat (ictus cordis)...
June 2017: Topics in Companion Animal Medicine
https://www.readbyqxmd.com/read/28989817/medical-and-surgical-advancements-in-the-management-of-cystic-fibrosis-chronic-rhinosinusitis
#14
Kiranya E Tipirneni, Bradford A Woodworth
PURPOSE OF REVIEW: The purpose of this review is to provide otolaryngologists with the most up-to-date advancements in both the medical and surgical management of CF-related sinus disease. RECENT FINDINGS: Recent studies have supported more aggressive CRS management, often with a combination of both medical and surgical therapies. Comprehensive treatment strategies have been shown to reduce hospital admissions secondary to pulmonary exacerbations in addition to improving CRS symptoms...
March 2017: Current Otorhinolaryngology Reports
https://www.readbyqxmd.com/read/28963721/relationship-between-chronic-rhinosinusitis-exacerbation-frequency-and-asthma-control
#15
Raphael G Banoub, Katie M Phillips, Lloyd P Hoehle, David S Caradonna, Stacey T Gray, Ahmad R Sedaghat
OBJECTIVES/HYPOTHESIS: To determine the association between the frequency of acute chronic rhinosinusitis (CRS) exacerbations (AECRS) and the degree of asthma control in asthmatic CRS patients. STUDY DESIGN: Cross-sectional study. METHODS: We prospectively recruited 108 asthmatic CRS patients as participants. Asthma control was assessed using the Asthma Control Test (ACT). The frequency of AECRS was assessed using three previously described indirect metrics for AECRS: the frequency of patient-reported sinus infections, CRS-related antibiotics use, and CRS-related oral corticosteroids use in the last 3 months...
September 30, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28961815/quality-of-antibiotic-prescribing-of-swiss-primary-care-physicians-with-high-prescription-rates-a-nationwide-survey
#16
Dominik Glinz, Selene Leon Reyes, Ramon Saccilotto, Andreas F Widmer, Andreas Zeller, Heiner C Bucher, Lars G Hemkens
Objectives: To assess the quality of antibiotic prescribing of Swiss primary care physicians with high prescription rates. Methods: In January 2015, we mailed a structured questionnaire to 2900 primary care physicians in Switzerland. They were included in a nationwide pragmatic randomized controlled trial on routine antibiotic prescription monitoring and feedback based on health insurance claims data. We asked them to record the diagnosis and antibiotic treatment for 44 consecutive patients with the most common conditions associated with antibiotic prescribing in primary care...
November 1, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28895150/chemosensory-function-before-and-after-multimodal-treatment-in-chronic-rhinosinusitis-patients
#17
Ute Walliczek-Dworschak, Robert Pellegrino, Franziska Taube, Christian A Mueller, Boris Alexander Stuck, Philipp Dworschak, Christian Güldner, Silke Steinbach
OBJECTIVES/HYPOTHESIS: Olfactory dysfunction is common among the general population, with chronic rhinosinusitis (CRS) as one of the leading causes. Patients affected by CRS often report changes in taste sensations; however, quantitative measurements have not been performed to date. Therefore, the present study aimed to investigate gustatory and olfactory function in CRS patients prior to and after multimodal treatment. STUDY DESIGN: Prospective cohort study. METHODS: Twenty-one patients suffering from CRS with nasal polyps (14 male, seven female) with a mean age of 48 ± 15 years were included in the study...
September 12, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28894828/the-role-of-antibiotics-in-pediatric-chronic-rhinosinusitis
#18
REVIEW
Itzhak Brook
OBJECTIVES: Presenting the role of antibiotics in pediatric chronic rhinosinusitis based on its pathophysiology and microbiology. DATA SOURCE: Review of the literature searching PubMed for microbiology and treatment of pediatric chronic rhinosinusitis. RESULTS: Chronic rhinosinusitis (CRS) is an inflammatory condition of the paranasal sinuses that persists for 12 weeks or longer, despite medical management. The microbiology of rhinosinusitis evolves through several stages...
June 2017: Laryngoscope Investigative Otolaryngology
https://www.readbyqxmd.com/read/28894821/the-role-of-infection-and-antibiotics-in-chronic-rhinosinusitis
#19
REVIEW
Miriam Baron Barshak, Marlene L Durand
OBJECTIVE: To review the current understanding of the role of infection and antibiotics in chronic rhinosinusitis. REVIEW METHODS: PubMed literature search. RESULTS: Chronic rhinosinusitis (CRS) in adults is an inflammatory condition and the role of infection is unclear. Biofilms are present in both CRS and normal patients so their role in CRS is unknown. Sinus cultures in CRS demonstrate a mixture of aerobic and anaerobic bacteria but may be hard to interpret due to contaminating nasal flora...
February 2017: Laryngoscope Investigative Otolaryngology
https://www.readbyqxmd.com/read/28887201/reactive-oxygen-therapy-a-novel-antimicrobial
#20
REVIEW
Matthew Dryden
The main solution to the global antibiotic resistance crisis is reducing the volume of antibiotic use in medicine, agriculture and the environment. However there is also a pressing need for novel antimicrobials. Despite much rhetoric, there are few entirely novel agents in development. One such therapy to reach clinical use is an agent using Reactive Oxygen Species (ROS), oxygen radicals, as an antimicrobial mechanism. ROS can be delivered to the site of infection in various formats. ROS is highly antimicrobial against Gram positive and negative bacteria, viruses and fungi...
September 5, 2017: International Journal of Antimicrobial Agents
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