keyword
https://read.qxmd.com/read/38506028/-acute-and-chronic-rhinosinusitis-age-characteristics
#1
JOURNAL ARTICLE
S V Ryazantsev, I M Kirichenko, E L Savlevich, V I Popadyuk, N S Kozlova, A I Chernolev
Children's and adults' rhinosinusitis are two diseases that have both similarities and differences in anatomy, epidemiology, causes, pathogenesis, diagnosis and treatment. At the same rhinosinusitis is one of the most common in otorhinolaryngology's practice, both in children and adults. The of adults paranasal sinuses (PNS) anatomy differs from children's PNS anatomy. Although ostiomeatal complex occlusion is recognized as a major cause of poor ventilation and drainage of the adult paranasal sinuses, it does not have a strong effect on pediatric rhinosinusitis, but adenoids play a key role...
2024: Vestnik Otorinolaringologii
https://read.qxmd.com/read/38497762/clinical-outcomes-of-functional-endoscopic-sinus-surgery-in-cystic-fibrosis-patients-a-single-centre-experience
#2
JOURNAL ARTICLE
Y Devabalan, R Towning, J Magill, H Saleh, C Rennie
BACKGROUND: Endoscopic sinus surgery (ESS) is an established surgical option for cystic fibrosis (CF) patients with chronic rhinosinusitis that is refractory to conventional medical management. Objective and subjective evidence of benefit of ESS in this cohort of patients is currently conflicting in the literature. METHODOLOGY: A single center retrospective study was undertaken of all CF patients (transplanted and non-transplanted) over the age of 16 who underwent an ESS over a six-year period from 2015 to 2021...
March 18, 2024: Rhinology
https://read.qxmd.com/read/38472346/-difficult-to-treat-chronic-rhinosinusitis-when-the%C3%A2-standard-treatment-is-not-effective-and-biologics-are-not-available
#3
REVIEW
Robert Böscke
BACKGROUND: In recent years, significant improvements have been made in the treatment options for uncontrolled chronic rhinosinusitis (CRS) refractory to standard medical and surgical therapy. This is the result of a better understanding of the pathophysiology and the resulting development of biologicals for CRS with nasal polyps (CRSwNP). However, biologics are not (yet) available for all patients in Europe. OBJECTIVE: Based on the session "Difficult-to-treat CRS, when biologics are not available" at the 29th Congress of the European Rhinologic Society (ERS) 2023 in Sofia, Bulgaria, the treatment options for uncontrolled CRS with the exclusion of biologics will be discussed...
April 2024: HNO
https://read.qxmd.com/read/38459950/microbial-analysis-in-chronic-rhinosinusitis-patients-with-chronic-kidney-disease-and-end-stage-renal-disease
#4
JOURNAL ARTICLE
Sheng-Wei Lo, Meng-Chang Ding, Yao-Te Tsai, Ming-Shao Tsai, Chia-Yen Liu, Cheng-Ming Hsu, Yao-Hsu Yang, Geng-He Chang
INTRODUCTION: This study aimed to elucidate the bacterial profile of chronic rhinosinusitis (CRS) in patients with end-stage renal disease (ESRD) and chronic kidney disease (CKD) compared with nonrenal patients, guiding antibiotic selection for clinicians. METHODS: We retrospectively analyzed 13,906 inpatients from the Chang Gung Research Database who underwent sinus surgery (2004-2018). Patients were categorized into ESRD-CRS, CKD-CRS, and non-CKD-CRS based on the estimated glomerular filtration rate...
March 9, 2024: Laryngoscope
https://read.qxmd.com/read/38440589/nasal-microbiota-and-sensitivity-pattern-in-rhinosinusitis
#5
JOURNAL ARTICLE
Prerana P, Arvind Sangavi, Venkatesh U, Saif Naziruddin Saiyad, Bhushan Chickle
AIMS: To know the microorganism causing rhinosinusitis & to study the antibiotic sensitivity pattern for the isolated nasal microbiota in this region. BACKGROUND: Rhinosinusitis is inflammatory condition of nose and paranasal sinuses [1]. It is multifactorial condition, in which microorganisms play pathogenic role [2]. Interactions between microorganisms, mucosa and environmental changes influence on composition of bacterial ecosystem [2]. Though antibiotics are frequently used for medical management of rhinosinusitis, sensitivity directed antibiotics are rarely prescribed...
February 2024: Indian Journal of Otolaryngology and Head and Neck Surgery
https://read.qxmd.com/read/38440469/a-prospective-clinical-study-of-bacteriological-profile-and-their-antibiotic-susceptibilty-profile-in-patients-with-chronic-rhinosinusitis-the-recent-scenario-in-northern-india
#6
JOURNAL ARTICLE
Nainsi Gupta, Aftab Ahmed, Rubina Galib, Adil Raza
OBJECTIVES: 1. To determine the prevailing scenario of the bacteriological profile of patients with CRS, 2. To identify their antibiotic susceptibility profile. MATERIAL AND METHODS: The study was conducted on 100 patients in the Department of ENT and Microbiology from December 2020-2022. Patients above the age of 12 years were evaluated. Those who received antibiotics in the last 12 months. and age < 12 years were excluded. Patients were subjected to a detailed history, clinical and radiological examination...
February 2024: Indian Journal of Otolaryngology and Head and Neck Surgery
https://read.qxmd.com/read/38286789/-cymbopogon-citratus-l-essential-oil-as-a-potential-anti-biofilm-agent-active-against-antibiotic-resistant-bacteria-isolated-from-chronic-rhinosinusitis-patients
#7
JOURNAL ARTICLE
Mintra Khosakueng, Suwimol Taweechaisupapong, Wongwarut Boonyanugomol, Pornpan Prapatpong, Saharut Wongkaewkhiaw, Sakawrat Kanthawong
Chronic rhinosinusitis (CRS) is long-term inflammation of the sinuses that can be caused by infection due to antibiotic-resistant bacteria. Biofilm developed by microbes is postulated to cause antibiotic treatment failure. Thus, the anti-biofilm activities of seven Thai herbal essential oils (EOs) against antibiotic-resistant bacteria isolated from CRS patients was investigated. Lemongrass ( Cymbopogon citratus L.) EO showed the most effective antibiofilm activity against Klebsiella pneumoniae , Pseudomonas aeruginosa and Staphylococcus epidermidis grown as biofilm...
January 29, 2024: Biofouling
https://read.qxmd.com/read/38268092/frailty-is-an-independent-predictor-of-postoperative-rescue-medication-use-after-endoscopic-sinus-surgery
#8
JOURNAL ARTICLE
Kolin E Rubel, Andrea Lopez, Rory J Lubner, Diane L Lee, Kristen Yancey, Rakesh K Chandra, Naweed I Chowdhury, Justin H Turner
INTRODUCTION: The modified five-item frailty index (mFI-5) is a validated risk stratification tool with the ability to predict adverse outcomes following surgery. In this study, we sought to use mFI-5 to assess the potential relationship between unhealthy aging and postoperative endoscopic sinus surgery (ESS) outcomes. METHODS: Patients who underwent sinus surgery at Vanderbilt between 2014 and 2018 were identified and assessed using the mFI-5, which is calculated based on the presence of five comorbidities: diabetes mellitus, hypertension requiring medication, chronic obstructive pulmonary disease, congestive heart failure, and non-independent functional status...
January 24, 2024: International Forum of Allergy & Rhinology
https://read.qxmd.com/read/38262225/orbital-complications-of-sinusitis-in-children-retrospective-analysis-of-an-8-5-year-experience
#9
JOURNAL ARTICLE
Vera Lohnherr, Ingo Baumann
OBJECTIVE: Orbital complications account for approximately 74-85 % of all complications of acute sinusitis, affect the pediatric population more frequently, and can have devastating consequences. In the years following the COVID-19 pandemic (2022, 2023), a high number of children presented to our clinic with orbital complications. 1)Has there been an increase in orbital complications in the post-covid era? 2)To what extent has the use of MRI reduced radiation in pediatric patients? DESIGN: In our retrospective data analysis, all pediatric patients (age 0-16 years) treated at a university ENT clinic during the period 01/2014-06/2023 who presented with an orbital complication of rhinosinusitis were included...
February 2024: International Journal of Pediatric Otorhinolaryngology
https://read.qxmd.com/read/38251402/a-pharmacist-s-role-in-a-case-of-allergy-labeling-and-acute-bacterial-rhinosinusitis-treatment
#10
Megan R Undeberg, Dana R Bowers, Cindy N Chau, Kimberly C McKeirnan
This case report describes a pharmacist's intervention with a 58-year-old female who presented with recurrent rhinosinusitis symptoms and limited treatment options due to a complicated allergy history. Using guidelines for treatment of acute bacterial rhinosinusitis coupled with a thorough antibiotic allergy assessment, the pharmacist developed a treatment plan that was acceptable to both the patient and the provider. Pharmacists can play an essential role in verification of allergies to both medications and non-pharmaceutical products, which further ensures patient safety as well as optimization of appropriate treatment methods...
January 3, 2024: Pharmacy (Basel, Switzerland)
https://read.qxmd.com/read/38173477/identification-of-the-role-of-pyroptosis-related-genes-in-chronic-rhinosinusitis-based-on-wgcna
#11
JOURNAL ARTICLE
Yarui Wan, Yanfei Wang, Sheng Xu, Hui Du, Zhiqi Liu
BACKGROUND: Chronic rhinosinusitis (CRS) is a complex chronic inflammatory disease of the nose, paranasal sinus, and upper respiratory tract. Its treatment methods mainly include antibiotic treatment and surgical treatment. However, the molecular mechanism of its inflammation is still unclear. Pyroptosis is a programmed cell death. As an important natural immune response, pyroptosis plays an essential role in fighting infection. METHODS: In this paper, a weighted co-expression network (WGCNA) was used to screen gene modules significantly related to CRS...
January 15, 2024: Heliyon
https://read.qxmd.com/read/38153893/-phage-therapy-in-overcoming-antibiotic-resistance-in-chronic-rhinosinusitis
#12
JOURNAL ARTICLE
A A Krivopalov, N V Moroz, E G Belicheva, M A Lengina
UNLABELLED: The relevance of the study is due to the observed increase in antibiotic resistance of the main pathogens of chronic rhinosinusitis. OBJECTIVE: To evaluate the effectiveness of phage therapy in the complex treatment of exacerbations of chronic rhinosinusitis. MATERIAL AND METHODS: The study included 55 patients with a verified diagnosis of chronic rhinosinusitis and a history of periodic exacerbations throughout the year, hospitalized at the St...
2023: Vestnik Otorinolaringologii
https://read.qxmd.com/read/38085499/remission-in-type-2-inflammatory-diseases-current-evidence-unmet-needs-and-suggestions-for-defining-remission-in-chronic-rhinosinusitis-with-nasal-polyps
#13
REVIEW
Marco Caminati, Eugenio De Corso, Giancarlo Ottaviano, Carlotta Pipolo, Michele Schiappoli, Veronica Seccia, Francesca Romana Spinelli, Edoardo Vincenzo Savarino, Paolo Gisondi, Gianenrico Senna
PURPOSE OF REVIEW: The development of biological therapies for type 2 inflammatory diseases raises the possibility of addressing remission in those dis-immune conditions. No consensus exists for a definition of remission in chronic rhinosinusitis with nasal polyps (CRSwNP). This review aims to critically evaluate the published data to provide the basis for defining remission in CRSwNP. RECENT FINDINGS: The published evidence has yet to provide an unequivocal definition on remission in type 2 inflammatory diseases, in part reflecting differences in approaches to diagnosis and follow-up...
December 12, 2023: Current Allergy and Asthma Reports
https://read.qxmd.com/read/38063253/surgery-for-nasal-polyposis-in-cystic-fibrosis
#14
REVIEW
Paula Ribeiro Lopes Almeida, Osmar C Person, Maria Es Puga, Álvaro N Atallah, Virginia Fm Trevisani
BACKGROUND: Cystic fibrosis (CF) is a life-shortening, autosomal recessive disease that leads to abnormal electrolyte concentration in exocrine secretions. Secretion stasis in paranasal sinuses determines chronic rhinosinusitis (CRS) and nasal polyposis. Endoscopic sinus surgery is used to open the sinuses and allow medical treatment to work properly. OBJECTIVES: To determine the effects of sinus surgery alone or in combination with medical treatment (non-surgical) compared to medical treatment (non-surgical) alone on both nasal and pulmonary function in people with CF diagnosed with CRS with nasal polyposis...
December 8, 2023: Cochrane Database of Systematic Reviews
https://read.qxmd.com/read/38058534/abducens-nerve-neuropraxia-due-to-acute-bacterial-rhinosinusitis-case-report-and-literature-review
#15
Abdulrahman Alghulikah, Sarah Alseneidi, Hedayah Alsaady, Ahmed Alhussien, Surayie Al-Dousary, Saud Alromaih, Abdulrahman AlHumaizi
BACKGROUND: Acute bacterial rhinosinusitis (ABRS) is a common infection of the paranasal sinuses that can lead to complications such as orbital and intracranial extension. The abducens nerve course is adjacent to the sphenoid sinus. Diplopia is rarely the initial presentation of sphenoid sinus pathology. In this article, we present the case of a middle-aged male who presented with diplopia and abducens nerve palsy secondary to ABRS, and we conducted a literature review in search of similar cases...
2023: Case Reports in Otolaryngology
https://read.qxmd.com/read/38046461/difficulty-in-management-of-acute-invasive-fungal-rhinosinusitis-in-indonesia-during-the-covid-19-pandemic-a-case-report
#16
Michael Lusida, M Vitanata Arifijanto, Brian Eka Rachman, Firas Farisi Alkaff
Invasive fungal rhinosinusitis is a rare disease with a high morbidity and mortality rate. Lately, COVID-19 has been associated with an increased incidence of this disease. We present the first case of COVID-19-associated acute invasive fungal rhinosinusitis found in Indonesia. The risk factors for the disease include corticosteroid use and antibiotic use. The case was complicated with left orbital cellulitis and cerebral abscess. Difficulty of management in Indonesia during the COVID-19 pandemic includes hesitancy of the patient to seek medical care and the availability of surgical team for COVID-19-positive patients...
2023: Respiratory Medicine Case Reports
https://read.qxmd.com/read/38043186/role-of-acute-rhinosinusitis-in-periorbital-infections-in-children
#17
JOURNAL ARTICLE
Amani Kais, Erica McArdle, Rafka Chaiban, Ruifeng Cui, Chadi A Makary, Hassan H Ramadan
OBJECTIVE: Periorbital cellulitis in children are commonly caused by acute rhinosinusitis (ARS). This study investigated the association of ARS and the severity of periorbital cellulitis in children. STUDY DESIGN: Retrospective case-control study of children with periorbital cellulitis with ARS versus periorbital cellulitis without ARS. SETTING: Patients were seen at West Virginia University Children's Hospitals between August 2011 to August 2022...
November 30, 2023: International Journal of Pediatric Otorhinolaryngology
https://read.qxmd.com/read/38032332/microbiota-and-antibiotic-therapy-in-rhinosinusitis
#18
JOURNAL ARTICLE
Lidia Zawadzka-Głos
Rhinosinusitis is one of the most frequently diagnosed diseases in patients seeking medical consultation. Sinusitis is a heterogeneous group of diseases and can be acute or chronic. The current state of knowledge on rhinosinusitis is presented in the recommendations of the European Position Paper on Rhinosynusitis and Nasal Polyps 2020 (EPOS 2020). More and more attention is paid to the condition of the microbiota in the context of inflammatory changes in the sinuses. There is also a negative effect of excessively prescribed antibiotics on the increase in bacterial resistance to drugs and significant changes in the disturbance in the composition of the microbiota during antibiotic therapy...
September 13, 2023: Otolaryngologia Polska
https://read.qxmd.com/read/38010322/the-intra-host-evolutionary-landscape-and-pathoadaptation-of-persistent-staphylococcus-aureus-in-chronic-rhinosinusitis
#19
JOURNAL ARTICLE
Ghais Houtak, George Bouras, Roshan Nepal, Gohar Shaghayegh, Clare Cooksley, Alkis James Psaltis, Peter-John Wormald, Sarah Vreugde
Chronic rhinosinusitis (CRS) is a common chronic sinonasal mucosal inflammation associated with Staphylococcus aureus biofilm and relapsing infections. This study aimed to determine rates of S. aureus persistence and pathoadaptation in CRS patients by investigating the genomic relatedness and antibiotic resistance/tolerance in longitudinally collected S. aureus clinical isolates. A total of 68 S . aureus paired isolates (34 pairs) were sourced from 34 CRS patients at least 6 months apart. Isolates were grown into 48 h biofilms and tested for tolerance to antibiotics...
November 2023: Microbial Genomics
https://read.qxmd.com/read/38004305/biologics-for-chronic-rhinosinusitis-a-modern-option-for-therapy
#20
REVIEW
Romica Cergan, Ovidiu Nicolae Berghi, Mihai Dumitru, Daniela Vrinceanu, Felicia Manole, Crenguta Sorina Serboiu
Chronic rhinosinusitis (CRS) is an important ENT pathology which affects about 5-12% of the general population. The treatment of CRS can be pharmacological (nasal sprays, douches, systemic antibiotics and steroids), surgical (endoscopic sinus surgery) or immunological according to established algorithms. CRS was divided for many years into CRS with nasal polyps (CRSwNP) and CRS without nasal polyps (CRSsNP). New ways of classifying CRS by endotypes (presence of neutrophilia, eosinophilia, fibrosis, glandular hypertrophy and epithelial dysmorphisms) appeared after the most recent understandings of the pathophysiology of the disease...
November 5, 2023: Life
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