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cystic fibrosis antibiotics

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https://www.readbyqxmd.com/read/28187782/sputum-dna-sequencing-in-cystic-fibrosis-non-invasive-access-to-the-lung-microbiome-and-to-pathogen-details
#1
Rounak Feigelman, Christian R Kahlert, Florent Baty, Frank Rassouli, Rebekka L Kleiner, Philipp Kohler, Martin H Brutsche, Christian von Mering
BACKGROUND: Cystic fibrosis (CF) is a life-threatening genetic disorder, characterized by chronic microbial lung infections due to abnormally viscous mucus secretions within airways. The clinical management of CF typically involves regular respiratory-tract cultures in order to identify pathogens and to guide treatment. However, culture-based methods can miss atypical or slow-growing microbes. Furthermore, the isolated microbes are often not classified at the strain level due to limited taxonomic resolution...
February 10, 2017: Microbiome
https://www.readbyqxmd.com/read/28184354/gallium-protoporphyrin-ix-inhibits-pseudomonas-aeruginosa-growth-by-targeting-cytochromes
#2
Sarah Hijazi, Paolo Visca, Emanuela Frangipani
Pseudomonas aeruginosa is a challenging pathogen due to both innate and acquired resistance to antibiotics. It is capable of causing a variety of infections, including chronic lung infection in cystic fibrosis (CF) patients. Given the importance of iron in bacterial physiology and pathogenicity, iron-uptake and metabolism have become attractive targets for the development of new antibacterial compounds. P. aeruginosa can acquire iron from a variety of sources to fulfill its nutritional requirements both in the environment and in the infected host...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28184305/once-daily-aerosolised-tobramycin-in-adult-patients-with-cystic-fibrosis-in-the-management-of-pseudomonas-aeruginosa-chronic-infection
#3
Marco Mantero, Andrea Gramegna, Giovanna Pizzamiglio, Alice D'Adda, Paolo Tarsia, Francesco Blasi
It is estimated that about 60-70% of Cystic Fibrosis patients develop Pseudomonas aeruginosa chronic infection, with progressive loss of lung function, as well as increased antibiotic resistance and mortality. The current strategy is to maintain lung function by chronic suppressive antipseudomonas antibiotic therapy. Tobramycin inhalation solution was the first approved aerosolised antibiotic to be used against P. aeruginosa; inhalatory tobramycin frequency of administration is twice daily and inhalation time is estimated to be 15 to 20 min...
2017: Multidisciplinary Respiratory Medicine
https://www.readbyqxmd.com/read/28178305/clinical-utility-of-c-reactive-protein-to-predict-treatment-response-during-cystic-fibrosis-pulmonary-exacerbations
#4
Ashutosh Sharma, Gordon Kirkpatrick, Virginia Chen, Kate Skolnik, Zsuzsanna Hollander, Pearce Wilcox, Bradley S Quon
RATIONALE: C-reactive protein (CRP) is a systemic marker of inflammation that correlates with disease status in cystic fibrosis (CF). The clinical utility of CRP measurement to guide pulmonary exacerbation (PEx) treatment decisions remains uncertain. OBJECTIVES: To determine whether monitoring CRP during PEx treatment can be used to predict treatment response. We hypothesized that early changes in CRP can be used to predict treatment response. METHODS: We reviewed all PEx events requiring hospitalization for intravenous (IV) antibiotics over 2 years at our institution...
2017: PloS One
https://www.readbyqxmd.com/read/28173787/first-time-identification-of-pandoraea-sputorum-from-a-patient-with-cystic-fibrosis-in-argentina-a-case-report
#5
Pablo F Martina, Mónica Martínez, Guillermo Frada, Florencia Alvarez, Lorena Leguizamón, Claudia Prieto, Carolina Barrias, Marisa Bettiol, Antonio Lagares, Alejandra Bosch, Julián Ferreras, Martha Von Specht
BACKGROUND: Pandoraea species are considered emerging pathogens in the context of cystic fibrosis (CF) and are difficult to identify by conventional biochemical methods. These multidrug resistant bacteria remain poorly understood particularly in terms of natural resistance, mechanisms of acquired resistance and impact on the prognosis of the disease and the lung function. Among them, Pandoraea sputorum has been previously described in few cases of CF patients from Spain, Australia, France and United States, underlining the need of more clinical data for a better knowledge of its pathogenicity...
February 7, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/28170403/longitudinal-assessment-of-sputum-microbiome-by-sequencing-of-the-16s-rrna-gene-in-non-cystic-fibrosis-bronchiectasis-patients
#6
Michael J Cox, Elena M Turek, Catherine Hennessy, Ghazala K Mirza, Phillip L James, Meg Coleman, Andrew Jones, Robert Wilson, Diana Bilton, William O C Cookson, Miriam F Moffatt, Michael R Loebinger
BACKGROUND: Bronchiectasis is accompanied by chronic bronchial infection that may drive disease progression. However, the evidence base for antibiotic therapy is limited. DNA based methods offer better identification and quantification of microbial constituents of sputum than standard clinical culture and may help inform patient management strategies. Our study objective was to determine the longitudinal variability of the non-cystic fibrosis (CF) bronchiectasis microbiome in sputum with respect to clinical variables...
2017: PloS One
https://www.readbyqxmd.com/read/28164789/preliminary-data-on-antibacterial-activity-of-echinacea-purpurea-associated-bacterial-communities-against-burkholderia-cepacia-complex-strains-opportunistic-pathogens-of-cystic-fibrosis-patients
#7
Carolina Chiellini, Isabel Maida, Valentina Maggini, Emanuele Bosi, Stefano Mocali, Giovanni Emiliani, Elena Perrin, Fabio Firenzuoli, Alessio Mengoni, Renato Fani
Burkholderia cepacia complex bacteria (Bcc) represent a serious threat for immune-compromised patient affected by Cystic Fibrosis (CF) since they are resistant to many substances and to most antibiotics. For this reason, the research of new natural compounds able to inhibit the growth of Bcc strains has raised new interest during the last years. A source of such natural compounds is represented by medicinal plants and, in particular, by bacterial communities associated with these plants able to produce molecules with antimicrobial activity...
March 2017: Microbiological Research
https://www.readbyqxmd.com/read/28144069/a-severe-mycoplasma-pneumoniae-pneumonia-inducing-an-acute-antibody-mediated-pulmonary-graft-rejection
#8
Sarah Démir, Julien Saison, Agathe Sénéchal, Jean-Francois Mornex
A 40-year-old cystic fibrosis woman with a history of double-lung transplantation 2 years previously was admitted for a progressive respiratory distress. Physical examination revealed fever (39°C) and diffuse bilateral lung crackles. Laboratory findings included severe hypoxemia and inflammatory syndrome. Bronchoalveolar lavage and serological test were positive for mycoplasma pneumonia. As the patient did not improve after 3 days of antibiotics and donor-specific HLA antibodies had been detected, an acute antibody-mediated graft rejection was treated with high-dose corticosteroids, plasma exchange, intravenous immunoglobulin, and rituximab...
January 2017: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/28137807/inhibition-of-pseudomonas-aeruginosa-by-peptide-conjugated-phosphorodiamidate-morpholino-oligomers
#9
James J Howard, Carolyn R Sturge, Dina A Moustafa, Seth M Daly, Kimberly R Marshall-Batty, Christina F Felder, Danniel Zamora, Marium Yabe-Gill, Maria Labandeira-Rey, Stacey M Bailey, Michael Wong, Joanna B Goldberg, Bruce L Geller, David E Greenberg
Pseudomonas aeruginosa is a highly virulent, multidrug-resistant pathogen that causes significant morbidity and mortality in hospitalized patients and is particularly devastating in those with cystic fibrosis (CF). Increasing antibiotic resistance coupled with decreasing numbers of antibiotics in the developmental pipeline demands novel antibacterial approaches. Here we tested peptide-conjugated phosphorodiamidate morpholino oligomers (PPMOs), which inhibit translation of complementary mRNA from specific, essential genes in P...
January 30, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28137803/importance-of-the-exopolysaccharide-matrix-in-antimicrobial-tolerance-of-pseudomonas-aeruginosa-aggregates
#10
Lise Goltermann, Tim Tolker-Nielsen
Pseudomonas aeruginosa is an opportunistic pathogen that can infect the lungs of cystic fibrosis (CF) patients, and persist in the form of antibiotic tolerant aggregates in the mucus. It has recently been suggested that such aggregates are formed due to restricted bacterial motility independent of the production of extracellular matrix components, and that they do not rely on an extracellular matrix for antimicrobial tolerance. However, we show here that biofilm matrix over-expression, as displayed by various clinical isolates, significantly protects P...
January 30, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28137800/the-mechanism-of-killing-by-the-proline-rich-peptide-bac7-1-35-against-clinical-strains-of-pseudomonas-aeruginosa-differs-from-that-showed-against-other-gram-negative-bacteria
#11
Giulia Runti, Monica Benincasa, Grazia Giuffrida, Giulia Devescovi, Vittorio Venturi, Renato Gennaro, Marco Scocchi
P. aeruginosa infections represent a serious threat to worldwide health. Proline-rich antimicrobial peptides (PR-AMPs), a particular group of peptide antibiotics, have demonstrated in vitro activity against P. aeruginosa strains. Here we show that the mammalian PR-AMP Bac7 (1-35) is active against some multi-drug-resistant cystic fibrosis isolates of P. aeruginosa By confocal microscopy and cytometric analyses we investigated the mechanism of killing against P. aeruginosa PAO1 and three selected isolates and we observed that the peptide inactivated the target cells by disrupting their cellular membranes...
January 30, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28133546/glomerular-and-tubular-renal-function-after-repeated-once-daily-tobramycin-courses-in-cystic-fibrosis-patients
#12
Florian Stehling, Rainer Büscher, Jörg Grosse-Onnebrink, Peter F Hoyer, Uwe Mellies
Introduction. Antibiotic treatment regimens against Pseudomonas aeruginosa lung infection in cystic fibrosis (CF) patients often include aminoglycoside antibiotics that may cause chronic renal failure after repeated courses. Aminoaciduria is an early marker of acute aminoglycoside-induced renal tubular dysfunction. We hypothesized that urinary amino acid reabsorption is decreased after repeated once-daily tobramycin therapies. Methods. In this prospective cross-sectional study creatinine clearance was estimated by the Schwartz and the Cockcroft-Gault formula...
2017: Pulmonary Medicine
https://www.readbyqxmd.com/read/28131546/a-qualitative-analysis-of-the-information-needs-of-parents-of-children-with-cystic-fibrosis-prior-to-first-admission
#13
Vera Fixter, Catherine Butler, Jo Daniels, Samantha Phillips
PURPOSE: Hospitalization can be stressful for patients and their families. Pre-hospitalization information is crucial in establishing a good basis for patient satisfaction. In order to develop better preparatory material for parents, this qualitative study explored whether parents of children with cystic fibrosis, admitted to a UK Children's Hospital, felt adequately prepared for their child's admission. DESIGN AND METHODS: Data were collected from twelve parents whose children had been admitted within the last two years for routine intravenous antibiotics...
January 25, 2017: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/28128097/high-level-resistance-to-meropenem-in-clinical-isolates-of-pseudomonas-aeruginosa-in-the-absence-of-carbapenemases-role-of-active-efflux-and-porin-alterations
#14
Hussein Chalhoub, Yolanda Sáenz, Hector Rodriguez-Villalobos, Olivier Denis, Barbara C Kahl, Paul M Tulkens, Françoise Van Bambeke
High-level carbapenem resistance is worryingly increasing in clinical isolates and is often attributed to carbapenemase expression. This study aimed to determine the mechanisms leading to high-level meropenem resistance in six carbapenemase-negative Pseudomonas aeruginosa isolated from cystic fibrosis (CF) patients and seven carbapenemase-positive isolates from patients suffering from hospital-acquired pneumonia (HAP). MICs were determined in the absence or presence of l-arginine or glycine-glutamate as competitive substrates for OprD (OccD1) or OpdP (OccD3), respectively, or the efflux pump inhibitor Phe-Arg β-naphthylamide (PAβN)...
December 2016: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28127392/bacterial-competition-and-quorum-sensing-signalling-shape-the-eco-evolutionary-outcomes-of-model-in-vitro-phage-therapy
#15
Rachel Mumford, Ville-Petri Friman
The rapid rise of antibiotic resistance has renewed interest in phage therapy - the use of bacteria-specific viruses (phages) to treat bacterial infections. Even though phages are often pathogen-specific, little is known about the efficiency and eco-evolutionary outcomes of phage therapy in polymicrobial infections. We studied this experimentally by exposing both quorum-sensing (QS) signalling PAO1 and QS-deficient lasR Pseudomonas aeruginosa genotypes (differing in their ability to signal intraspecifically) to lytic PT7 phage in the presence and absence of two bacterial competitors: Staphylococcus aureus and Stenotrophomonas maltophilia-two bacteria commonly associated with P...
February 2017: Evolutionary Applications
https://www.readbyqxmd.com/read/28127379/antibiofilm-and-antioxidant-activity-of-propolis-and-bud-poplar-resins-versus-pseudomonas-aeruginosa
#16
Stefania De Marco, Miranda Piccioni, Rita Pagiotti, Donatella Pietrella
Pseudomonas aeruginosa is a common biofilm-forming bacterial pathogen implicated in lung, skin, and systemic infections. Biofilms are majorly associated with chronic lung infection, which is the most severe complication in cystic fibrosis patients characterized by drug-resistant biofilms in the bronchial mucus with zones, where reactive oxygen species concentration is increased mainly due to neutrophil activity. Aim of this work is to verify the anti-Pseudomonas property of propolis or bud poplar resins extracts...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28126911/characterization-of-inpatient-cystic-fibrosis-pulmonary-exacerbations
#17
Jonathan D Cogen, Assaf P Oron, Ronald L Gibson, Lucas R Hoffman, Matthew P Kronman, Thida Ong, Margaret Rosenfeld
BACKGROUND AND OBJECTIVES: Pulmonary exacerbations lead to significant morbidity and mortality in patients with cystic fibrosis (CF). National consensus guidelines exist, but few studies report current practice in the treatment and monitoring of pulmonary exacerbations. The goal of this study was to characterize consistency and variability in the inpatient management of CF-related pulmonary exacerbations. We focused on the use of guideline-recommended maintenance therapies, antibiotic selection and treatment regimens, use of systemic corticosteroids, and frequency of lung function testing...
February 2017: Pediatrics
https://www.readbyqxmd.com/read/28124968/-accurate-diagnosis-of-pseudomonas-luteola-in-routine-microbiology-laboratory-on-the-occasion-of-two-isolates
#18
Muharrem Çiçek, Gülşen Hasçelik, H Kaan Müştak, K Serdar Diker, Burçin Şener
Pseudomonas luteola which was previously known as Chryseomonas luteola; is a gram-negative, non-fermentative, aerobic, motile, non-spore-forming bacillus. It is frequently found as a saprophyte in soil, water and other damp environments and is an opportunistic pathogen in patients with underlying medical disorders or with indwelling catheters. It has been reported as an uncommon cause of bacteremia, sepsis, septic arthritis, meningitis, endocarditis, and peritonitis. Thus, early and accurate identification of this rare species is important for the treatment and also to provide information about the epidemiology of P...
October 2016: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/28124652/culture-directed-topical-antibiotic-treatment-for-chronic-rhinosinusitis
#19
Victoria S Lee, Greg E Davis
BACKGROUND: Topical antibiotics, delivered optimally as high-volume culture-directed sinus irrigations, are being increasingly used for recalcitrant chronic rhinosinusitis (CRS). Their impact on subjective and objective outcome measures, however, is still unclear. OBJECTIVE: To assess if the use of topical antibiotics in recalcitrant CRS is associated with improved 20-Item Sino-Nasal Outcome Test and Lund-Kennedy endoscopic scores, and to determine the negative posttreatment culture "control" rate...
November 1, 2016: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/28118021/notification-of-nontuberculous-mycobacteria-an-australian-perspective
#20
Rachel Thomson, Ellen Donnan, Anastasios Konstantinos
In Queensland, Australia, all cases of mycobacterial infection (TB and NTM) are notifiable under the Queensland Public Health Act (2005). This process originally emerged to avoid NTM confounding with notification of cases of Tuberculosis, but has facilitated awareness of the increasing incidence and changing epidemiology of NTM.(1) While initially not a public health priority, the notification process has facilitated research that has led to an appreciation of both public health and environmental health issues associated with these pathogens...
January 24, 2017: Annals of the American Thoracic Society
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