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https://www.readbyqxmd.com/read/29777043/new-advances-in-amblyopia-therapy-i-binocular-therapies-and-pharmacologic-augmentation
#1
Courtney L Kraus, Susan M Culican
Amblyopia therapy options have traditionally been limited to penalisation of the non-amblyopic eye with either patching or pharmaceutical penalisation. Solid evidence, mostly from the Pediatric Eye Disease Investigator Group, has validated both number of hours a day of patching and days per week of atropine use. The use of glasses alone has also been established as a good first-line therapy for both anisometropic and strabismic amblyopia. Unfortunately, visual acuity equalisation or even improvement is not always attainable with these methods...
May 18, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29754206/convective-influx-glymphatic-system-tracers-injected-into-the-csf-enter-and-leave-the-brain-along-separate-periarterial-basement-membrane-pathways
#2
Nazira J Albargothy, David A Johnston, Matthew MacGregor-Sharp, Roy O Weller, Ajay Verma, Cheryl A Hawkes, Roxana O Carare
Tracers injected into CSF pass into the brain alongside arteries and out again. This has been recently termed the "glymphatic system" that proposes tracers enter the brain along periarterial "spaces" and leave the brain along the walls of veins. The object of the present study is to test the hypothesis that: (1) tracers from the CSF enter the cerebral cortex along pial-glial basement membranes as there are no perivascular "spaces" around cortical arteries, (2) tracers leave the brain along smooth muscle cell basement membranes that form the Intramural Peri-Arterial Drainage (IPAD) pathways for the elimination of interstitial fluid and solutes from the brain...
May 12, 2018: Acta Neuropathologica
https://www.readbyqxmd.com/read/29746530/survey-of-potential-receptivity-to-robotic-assisted-exercise-coaching-in-a-diverse-sample-of-smokers-and-nonsmokers
#3
Christi Patten, James Levine, Ioannis Pavlidis, Joyce Balls-Berry, Arya Shah, Christine Hughes, Tabetha Brockman, Miguel Valdez Soto, Daniel Witt, Gabriel Koepp, Pamela Sinicrope, Jamie Richards
A prior project found that an intensive (12 weeks, thrice weekly sessions) in-person, supervised, exercise coaching intervention was effective for smoking cessation among depressed women smokers. However, the sample was 90% White and of high socioeconomic status, and the intensity of the intervention limits its reach. One approach to intervention scalability is to deliver the supervised exercise coaching using a robotic human exercise trainer. This is done in real time via an iPad tablet placed on a mobile robotic wheel base and controlled remotely by an iOS device or computer...
2018: PloS One
https://www.readbyqxmd.com/read/29740914/effects-of-physical-activity-on-psychological-well-being-outcomes-in-breast-cancer-survivors-from-pre-diagnosis-to-post-treatment-survivorship
#4
Susan Aguiñaga, Diane K Ehlers, Josh Cosman, Joan Severson, Arthur F Kramer, Edward McAuley
OBJECTIVE: The purpose of this study was to examine the effects of physical activity from pre-diagnosis to post-treatment survivorship on the psychological well-being (PWB) outcomes of fatigue, depression, anxiety, and quality of life (QoL) in breast cancer survivors (BCS). METHODS: Participants (N=387) completed a questionnaire battery using an iPad-based platform. Measures included self-reported PA (before diagnosis and currently), and perceptions of fatigue, depression, anxiety, and QoL...
May 8, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/29728192/comparison-of-the-computer-aided-articulation-therapy-application-with-printed-material-in-children-with-speech-sound-disorders
#5
Rana Dural, Özlem Ünal-Logacev
OBJECTIVES: The aim of the present study was to develop an iPad application for computer-aided articulation therapy called the Turkish Articulation Therapy Application (TARTU), and make comparisons between the efficacy of TARTU and printed material. METHOD: A single subject research design, adapted alternating treatments model, was used for this purpose. The study was carried out with 2 children, at the age of 5; 1 and 5; 11, both of whom have a speech sound disorder...
June 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29720876/can-a-single-session-of-motor-imagery-promote-motor-learning-of-locomotion-in-older-adults-a-randomized-controlled-trial
#6
Vaughan P Nicholson, Justin Wl Keogh, Nancy L Low Choy
Purpose: To investigate the influence of a single session of locomotor-based motor imagery training on motor learning and physical performance. Patients and methods: Thirty independent adults aged >65 years took part in the randomized controlled trial. The study was conducted within an exercise science laboratory. Participants were randomly divided into three groups following baseline locomotor testing: motor imagery training, physical training, and control groups...
2018: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29718523/cost-effective-virtual-clinical-site-visits-for-nurse-practitioner-students
#7
Suzanne Alton, Sheba A Luke, Maureen Wilder
BACKGROUND: Clinical site visits (CSVs) are critical to assess the progress of nurse practitioner (NP) students. To overcome the challenges of effectively assessing long-distance students while maintaining a reasonable faculty workload, faculty implemented a project using FaceTime® to conduct online CSVs to assess NP student progress. FaceTime is a videoconferencing program available on Apple® devices. METHOD: Site visits were conducted by school of nursing faculty with real-time observation of the NP student-patient encounter...
May 1, 2018: Journal of Nursing Education
https://www.readbyqxmd.com/read/29714498/an-electronic-screening-system-for-oral-health-examination-and-collection-of-critical-data-in-a-nonclinical-setting-validation-trial
#8
Joseph R Greenberg, Stephen Sinclair, Cheryl A Janssen, Kevin Krick, Mimi O'Brien, Kate Flanagan, Michael A Posner
OBJECTIVE: To evaluate the reliability, ease, and efficiency of data entry for an oral health screening app that allows iPad® entry of data, including permanent versus deciduous teeth present, visual image comparison grading of demineralization/caries, fluorosis, periodontal inflammation, oral hygiene status, identification of sealants/restorations, dental trauma, orthodontic malocclusion, mandibular joint dysfunction, and early childhood caries. METHODS: 89 consented children were examined first by a public health dental hygienist in a dental office reception area and then by a dentist in a treatment operatory...
May 2018: Compendium of Continuing Education in Dentistry
https://www.readbyqxmd.com/read/29710115/effects-of-a-tablet-based-home-practice-program-with-telepractice-on-treatment-outcomes-in-chronic-aphasia
#9
Jacquie Kurland, Anna Liu, Polly Stokes
Purpose: The aim of this study was to determine if a tablet-based home practice program with weekly telepractice support could enable long-term maintenance of recent treatment gains and foster new language gains in poststroke aphasia. Method: In a pre-post group study of home practice outcomes, 21 individuals with chronic aphasia were examined before and after a 6-month home practice phase and again at follow-up 4 months later. The main outcome measure studied was change in naming previously treated or untreated, practiced or unpracticed pictures of objects and actions...
April 24, 2018: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/29708852/fab-is-the-most-efficient-format-to-express-functional-antibodies-by-yeast-surface-display
#10
Coline Sivelle, Raphaël Sierocki, Kelly Ferreira-Pinto, Stéphanie Simon, Bernard Maillere, Hervé Nozach
Multiple formats are available for engineering of monoclonal antibodies (mAbs) by yeast surface display, but they do not all lead to efficient expression of functional molecules. We therefore expressed four anti-tumor necrosis factor and two anti-IpaD mAbs as single-chain variable fragment (scFv), antigen-binding fragment (Fab) or single-chain Fabs and compared their expression levels and antigen-binding efficiency. Although the scFv and scFab formats are widely used in the literature, 2 of 6 antibodies were either not or weakly expressed...
April 30, 2018: MAbs
https://www.readbyqxmd.com/read/29695113/presentation-attack-detection-for-iris-recognition-system-using-nir-camera-sensor
#11
Dat Tien Nguyen, Na Rae Baek, Tuyen Danh Pham, Kang Ryoung Park
Among biometric recognition systems such as fingerprint, finger-vein, or face, the iris recognition system has proven to be effective for achieving a high recognition accuracy and security level. However, several recent studies have indicated that an iris recognition system can be fooled by using presentation attack images that are recaptured using high-quality printed images or by contact lenses with printed iris patterns. As a result, this potential threat can reduce the security level of an iris recognition system...
April 24, 2018: Sensors
https://www.readbyqxmd.com/read/29686977/a-prototype-exercise-empowerment-mobile-video-game-for-children-with-cancer-and-its-usability-assessment-developing-digital-empowerment-interventions-for-pediatric-diseases
#12
Carol S Bruggers, Sabrina Baranowski, Mathew Beseris, Rachel Leonard, Derek Long, Elizabeth Schulte, Ashton Shorter, Rowan Stigner, Clinton C Mason, Alisa Bedrov, Ian Pascual, Grzegorz Bulaj
Background: Medical advances continue to improve morbidity and mortality of serious pediatric diseases, including cancer, driving research addressing diminished physical and psychological quality of life in children with these chronic conditions. Empowerment enhances resilience and positively influences health, disease, and therapy understanding. We describe the development and usability assessment of a prototype Empower Stars! mobile video game grounded in behavioral and exercise theories with the purpose of coupling physical exercise with empowerment over disease in children with cancer...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29672980/using-disruptive-insertional-mutagenesis-to-identify-the-in-situ-structure-function-landscape-of-the-shigella-translocator-protein-ipab
#13
Michael L Barta, Shoichi Tachiyama, Meenakumari Muthuramalingam, Olivia Arizmendi, Cecilia E Villanueva, Kasra X Ramyar, Brian V Geisbrecht, Scott Lovell, Kevin P Battaile, Wendy L Picking, William D Picking
Bacterial type III secretion systems (T3SS) are used to inject proteins into mammalian cells to subvert cellular functions. The Shigella T3SS apparatus (T3SA) is comprised of a basal body, cytoplasmic sorting platform and exposed needle with needle "tip complex" (TC). TC maturation occurs when the translocator protein IpaB is recruited to the needle tip where both IpaD and IpaB control secretion induction. IpaB insertion into the host membrane is the first step of translocon pore formation and secretion induction...
April 19, 2018: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/29671643/differences-in-praxis-performance-and-receptive-language-during-fingerspelling-between-deaf-children-with-and-without-autism-spectrum-disorder
#14
Anjana N Bhat, Sudha M Srinivasan, Colleen Woxholdt, Aaron Shield
Children with autism spectrum disorder present with a variety of social communication deficits such as atypicalities in social gaze and verbal and non-verbal communication delays as well as perceptuo-motor deficits like motor incoordination and dyspraxia. In this study, we had the unique opportunity to study praxis performance in deaf children with and without autism spectrum disorder in a fingerspelling context using American Sign Language. A total of 11 deaf children with autism spectrum disorder and 11 typically developing deaf children aged between 5 and 14 years completed a fingerspelling task...
April 2018: Autism: the International Journal of Research and Practice
https://www.readbyqxmd.com/read/29667301/the-feasibility-of-using-the-brighthearts-biofeedback-assisted-relaxation-application-for-the-management-of-pediatric-procedural-pain-a-pilot-study
#15
Karen L O Burton, Angela M Morrow, Brooke V Beswick, George P Khut
OBJECTIVE: The objective of this pilot study was to assess the acceptability and feasibility of using BrightHearts, a biofeedback-assisted relaxation application (app), in children undergoing painful procedures. METHODS: Thirty children 7 to 18 years of age undergoing a medical procedure (peripheral blood collection, botulinum toxin injection, or intravenous cannula insertion) participated. Participants used BrightHearts, a heart rate-controlled biofeedback-assisted relaxation training app delivered via an iPad with heart rate measured through a pulse oximeter worn on the ear or thumb...
April 17, 2018: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/29661702/adolescent-cancer-patients-perceived-quality-of-cancer-care-the-roles-of-patient-engagement-and-supporting-independence
#16
Elizabeth J Siembida, Nina S Kadan-Lottick, Kerry Moss, Keith M Bellizzi
OBJECTIVES: A lack of focus on variation in engagement among cancer populations of differing developmental stages led us to examine the associations between patient engagement, the patient-provider relationship, cognitive development, readiness to transition to adulthood (transitional readiness) and perceived quality of care. METHODS: A sample of 101 adolescent cancer patients (diagnosed 10-20 years) completed survey items concerning patient engagement, dimensions of the patient-provider relationship, cognitive development, transitional readiness, and demographic characteristics using an iPad/tablet during a routine clinic visit...
April 10, 2018: Patient Education and Counseling
https://www.readbyqxmd.com/read/29649398/feasibility-and-patient-perceptions-of-video-declarations-regarding-end-of-life-decisions-by-hospitalized-patients
#17
Lisa M Quintiliani, Jessica E Murphy, Pablo Buitron de la Vega, Katherine R Waite, S Emily Armstrong, Lori Henault, Angelo E Volandes, Michael K Paasche-Orlow
BACKGROUND: A videotaped declaration by patients of their advance care planning preferences could be an opportunity to supplement advance directive forms and be a source of information for family, caregivers, and clinicians, yet research is needed to examine the content and acceptability of making declarations among patients. OBJECTIVE: To evaluate the content and acceptability of 'video declarations': the process of patients videotaping themselves describing their advance care planning preferences...
March 13, 2018: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/29605443/are-the-electronic-and-paper-questionnaires-equivalent-in-assessing-patients-with-overactive-bladder
#18
Cristina Palmer, Bilal Farhan, Nobel Nguyen, Lishi Zhang, Rebecca Do, Danh V Nguyen, Gamal Ghoniem
INTRODUCTION: Overactive bladder (OAB) syndrome is defined as urinary urgency, usually accompanied by frequency and nocturia, with or without urgency urinary incontinence, in the absence of urinary tract infection (UTI) or other obvious pathology. Electronic questionnaires (eQs) have been used in few specialties with hopes of improving treatment outcomes and patient satisfaction. However, they have not been widely utilized in the urological field. In treating OAB the main outcome is to improve patient's quality of life...
March 29, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29597836/validation-of-a-novel-cost-effective-easy-to-produce-and-durable-in-vitro-model-for-kidney-puncture-and-pnl-simulation
#19
Jan Thorsten Klein, Jens Rassweiler, Marie-Claire Charlotte Rassweiler-Seyfried
INTRODUCTION: Nephrolithiasis is one of the most common diseases in urology. According to the EAU Guidelines, a percutaneous nephrolitholapaxy (PNL) is recommended when treating a kidney stone >2 cm. Nowadays PNL is performed even for smaller stones (<1 cm) using miniaturized instruments. The most challenging part of any PNL is the puncture of the planned site. PNL-novice surgeons need to practice this step in a safe environment with an ideal training model. We developed and evaluated a new, easy to produce, in-vitro model for the training of the freehand puncture of the kidney...
March 29, 2018: Journal of Endourology
https://www.readbyqxmd.com/read/29588860/technology-based-functional-assessment-in-early-childhood-intervention-a-pilot-study
#20
Mary A Khetani, Beth M McManus, Kristen Arestad, Zachary Richardson, Renee Charlifue-Smith, Cordelia Rosenberg, Briana Rigau
Background: Electronic patient-reported outcomes (e-PROs) may provide valid and feasible options for obtaining family input on their child's functioning for care planning and outcome monitoring, but they have not been adopted into early intervention (EI). The purpose of this pilot study was to evaluate the feasibility of implementing technology-based functional assessment into EI practice and to examine child, family, service, and environmental correlates of caregiver-reported child functioning in the home...
2018: Pilot and Feasibility Studies
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