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Herpes simplex virus and t cells

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https://www.readbyqxmd.com/read/27903680/herpes-simplex-virus-specific-t-cell-response-in-a-cohort-with-primary-genital-infection-correlates-inversely-with-frequency-of-subsequent-recurrences
#1
Elisabeth Franzen-Röhl, Danika Schepis, Fredrik Atterfelt, Kristina Franck, Arne Wikström, Jan-Åke Liljeqvist, Tomas Bergström, Elisabeth Aurelius, Klas Kärre, Louise Berg, Hans Gaines
OBJECTIVES: During the last decades, a changing epidemiological pattern of genital herpes simplex virus (HSV) infection has emerged. Primary infection is now caused as often by HSV-1 as by HSV-2. Once established, HSV can be reactivated leading to recurrent mucocutaneous lesions as well as meningitis. Why some otherwise immune-competent individuals experience severe and frequent recurrences is not known, and the immunological mechanism underlying recurrent symptomatic HSV infection is not fully understood...
November 30, 2016: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/27894330/marek-s-disease-in-chickens-a-review-with-focus-on-immunology
#2
REVIEW
Nitish Boodhoo, Angila Gurung, Shayan Sharif, Shahriar Behboudi
Marek's disease (MD), caused by Marek's disease virus (MDV), is a commercially important neoplastic disease of poultry which is only controlled by mass vaccination. Importantly, vaccines that can provide sterile immunity and inhibit virus transmission are lacking; such that vaccines are only capable of preventing neuropathy, oncogenic disease and immunosuppression, but are unable to prevent MDV transmission or infection, leading to emergence of increasingly virulent pathotypes. Hence, to address these issues, developing more efficacious vaccines that induce sterile immunity have become one of the important research goals for avian immunologists today...
November 28, 2016: Veterinary Research
https://www.readbyqxmd.com/read/27866863/il-2-complex-treatment-amplifies-cd8-t-cell-mediated-immunity-following-herpes-simplex-virus-1-infection
#3
Naveen K Rajasagi, Barry T Rouse
CD8(+) T cells play an important role in controlling numerous virus infections and some tumors and therefore several strategies have been adopted to modulate CD8(+) T cell responses. One such approach includes treatment with IL-2 bound to a monoclonal antibody against IL-2 (IL-2 complex) which was shown to enhance CD8(+) T cell responses and provide protection against some cancers and pathogens. This report analyses the value of IL-2 complex therapy to protect against a cutaneous virus infection as occurs with herpes simplex virus-1 (HSV-1) infection...
November 17, 2016: Microbes and Infection
https://www.readbyqxmd.com/read/27860276/regulation-of-kynurenine-biosynthesis-during-influenza-virus-infection
#4
Lana Gaelings, Sandra Söderholm, Andrii Bugai, Yu Fu, Jatin Nandania, Bert Schepens, Martina B Lorey, Janne Tynell, Liesbeth Vande Ginste, Ronan Le Goffic, Matthew S Miller, Marika Kuisma, Varpu Marjomäki, Jef De Brabander, Sampsa Matikainen, Tuula A Nyman, Dennis Bamford, Xavier Saelens, Ilkka Julkunen, Henrik Paavilainen, Veijo Hukkanen, Vidya Velagapudi, Denis E Kainov
Influenza A viruses (IAVs) remain serious threats to public health because of the shortage of effective means of control. Developing more effective virus control modalities requires better understanding of virus-host interactions. It has previously been shown that IAV induces the production of kynurenine, which suppresses T-cell responses, enhances pain hypersensitivity and disturbs behaviour in infected animals. However, the regulation of kynurenine biosynthesis during IAV infection remains elusive. Here we showed that IAV infection induced expression of interferons (IFNs), which upregulated production of indoleamine-2,3-dioxygenase (IDO1), which catalysed the kynurenine biosynthesis...
November 18, 2016: FEBS Journal
https://www.readbyqxmd.com/read/27859428/low-p16-ink4a-expression-in-early-passage-human-prostate-basal-epithelial-cells-enables-immortalization-by-telomerase-expression-alone
#5
Mindy Kim Graham, Lorenzo Principessa, Lizamma Antony, Alan K Meeker, John T Isaacs
BACKGROUND: There are two principal senescence barriers that must be overcome to successfully immortalize primary human epithelial cells in culture, stress-induced senescence, and replicative senescence. The p16(INK4a) /retinoblastoma protein (p16/Rb) pathway mediates stress-induced senescence, and is generally upregulated by primary epithelial cells in response to the artificial conditions from tissue culture. Replicative senescence is associated with telomere loss. Following each round of cell division, telomeres progressively shorten...
November 8, 2016: Prostate
https://www.readbyqxmd.com/read/27847359/human-asymptomatic-epitopes-identified-from-the-herpes-simplex-virus-tegument-protein-vp13-14-ul47-preferentially-recall-polyfunctional-effector-memory-cd44highcd62llowcd8-tem-cells-and-protect-humanized-hla-a-02-01-transgenic-mice-against-ocular-herpes
#6
Ruchi Srivastava, Arif A Khan, Sumit Garg, Sabrina A Syed, Julie N Furness, Hawa Vahed, Tiffany Pham, Howard T Yu, Anthony B Nesburn, Lbachir BenMohamed
: The herpes simplex virus type 1 (HSV-1) infection is widespread among humans. The HSV-1 virion protein 13/14 (VP13/14), also known as UL47, is a tegument antigen targeted by CD8(+) T cells from HSV-seropositive individuals. However, whether VP13/14-specific CD8(+) T cells play a role in the "natural protection" seen in asymptomatic (ASYMP) individuals (have never had a clinical herpetic disease) has not been elucidated. Using predictive computer-assisted algorithms, we identified 10 potential HLA-A*02:01-restricted CD8(+) T cell epitopes from the 693 amino acids sequence of VP13/14 protein...
November 9, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27835685/light-tnfsf14-increases-the-survival-and-proliferation-of-human-bone-marrow-derived-mesenchymal-stem-cells
#7
Sook-Kyoung Heo, Eui-Kyu Noh, Gi-Dong Gwon, Jeong Yi Kim, Jae-Cheol Jo, Yunsuk Choi, SuJin Koh, Jin Ho Baek, Young Joo Min, Hawk Kim
LIGHT (HVEM-L, TNFSF14, or CD258), an entity homologous to lymphotoxins, with inducible nature and the ability to compete with herpes simplex virus glycoprotein D for herpes virus entry mediator (HVEM)/tumor necrosis factor (TNF)-related 2, is a member of the TNF superfamily. It is expressed as a homotrimer on activated T cells and dendritic cells (DCs), and has three receptors: HVEM, LT-β receptor (LTβR), and decoy receptor 3 (DcR3). So far, three receptors with distinct cellular expression patterns are known to interact with LIGHT...
2016: PloS One
https://www.readbyqxmd.com/read/27817117/differences-in-t-cell-cytotoxicity-and-cell-death-mechanisms-between-progressive-multifocal-leukoencephalopathy-herpes-simplex-virus-encephalitis-and-cytomegalovirus-encephalitis
#8
Susanne Laukoter, Helmut Rauschka, Anna R Tröscher, Ulrike Köck, Etsuji Saji, Kurt Jellinger, Hans Lassmann, Jan Bauer
During the appearance of human immunodeficiency virus infection in the 1980 and the 1990s, progressive multifocal leukoencephalopathy (PML), a viral encephalitis induced by the JC virus, was the leading opportunistic brain infection. As a result of the use of modern immunomodulatory compounds such as Natalizumab and Rituximab, the number of patients with PML is once again increasing. Despite the presence of PML over decades, little is known regarding the mechanisms leading to death of infected cells and the role the immune system plays in this process...
November 5, 2016: Acta Neuropathologica
https://www.readbyqxmd.com/read/27815507/suppression-of-neointima-formation-by-targeting-%C3%AE-catenin-tcf-pathway
#9
Helen Williams, Sadie Slater, Sarah Jane George
Coronary artery disease is treated by vein grafting and stent implantation.  Late vein graft failure and restenosis of stented arteries reduces the success rates of these approaches and is caused by neointima formation. We have previously shown that Wnt proteins are upregulated during intimal thickening, and have speculated that these lead to activation of downstream genes with β-catenin/T-cell factor (TCF)-responsive promoters. In this study we aimed to provide evidence that β-catenin/TCF signalling promotes neointima formation and assess whether targeting this pathway has potential for reducing neointima formation...
November 4, 2016: Bioscience Reports
https://www.readbyqxmd.com/read/27803463/rapid-screening-by-cell-based-fusion-assay-for-identifying-novel-antivirals-of-glycoprotein-b-mediated-herpes-simplex-virus-type-1-infection
#10
Naoyoshi Maeda, Atsushi Furukawa, Kosuke Kakita, Masahiro Anada, Shunichi Hashimoto, Shigeki Matsunaga, Kimiko Kuroki, Toyoyuki Ose, Akihisa Kato, Jun Arii, Yasushi Kawaguchi, Hisashi Arase, Katsumi Maenaka
Herpes simplex virus type 1 (HSV-1) is a causative agent for a variety of diseases. Although antiherpetic drugs such as acyclovir have been developed to inhibit virus replication through interaction with DNA kinases, their continuous administration leads to an increase in the frequency of drug-resistant HSV-1, which is an important clinical issue that requires urgent solution. Recently, we reported that the sialylated O-linked sugar T antigen (sTn) and its attached peptide region (O-glycosylated sTn peptide) derived from the HSV-1 glycoprotein B (gB) protein inhibited HSV-1 infection by specifically targeting paired immunoglobulin-like type 2 receptor alpha (PILRα) in vitro...
2016: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27793552/herpes-simplex-virus-type-1-hsv-1-specific-t-cell-generation-from-hla-a1-and-hla-a2-positive-donors-for-adoptive-immunotherapy
#11
Chun K K Ma, Leighton Clancy, Shivashni Deo, Emily Blyth, Kenneth P Micklethwaite, David J Gottlieb
BACKGROUND AIMS: Herpes simplex virus (HSV) reactivation and infection is common in patients undergoing hematopoietic stem cell transplant (HSCT) and requires routine antiviral prophylaxis. Drug-resistant strains are increasingly common, and effective alternative therapy is currently unavailable. We generated and characterized HSV-1-specific T cells for use in adoptive cellular immunotherapy following allogeneic stem cell transplantation. METHODS: Peripheral blood mononuclear cells from HLA-A1 and HLA-A2 HSV-seropositive hereditary hemochromatosis donors were used as the antigen source...
October 25, 2016: Cytotherapy
https://www.readbyqxmd.com/read/27792980/synthesis-and-evaluation-of-novel-hybrids-%C3%AE-carboline-4-thiazolidinones-as-potential-antitumor-and-antiviral-agents
#12
Valéria Aquilino Barbosa, Paula Baréa, Renata Sespede Mazia, Tania Ueda-Nakamura, Willian Ferreira da Costa, Mary Ann Foglio, Ana Lucia T Goes Ruiz, João Ernesto de Carvalho, Débora Barbosa Vendramini-Costa, Celso Vataru Nakamura, Maria Helena Sarragiotto
A series of novel hybrids β-carboline-4-thiazolidinones were synthesized and evaluated for their in vitro antitumor activity against human cancer cell lines and for antiviral activity towards Herpes simplex virus type-1 (HSV-1). From the N'-(2-ylidene-4-thiazolidinone)-β-carboline-3-carbohydrazide series (9-11), compounds 9c and 11d were the most active, showing growth inhibition 50% (GI50) values less than 5 μM for all cell lines tested. Compound 9c, bearing the 4-dimethylaminophenyl group at C-1 of β-carboline was selected for further investigation concerning cell death and cell cycle profile, focusing on the human renal adenocarcinoma cell line 786-0...
October 11, 2016: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27791177/towards-a-transcriptome-based-theranostic-platform-for-unfavorable-breast-cancer-phenotypes
#13
Andrey S Dobroff, Sara D'Angelo, Bedrich L Eckhardt, Fortunato Ferrara, Daniela I Staquicini, Marina Cardó-Vila, Fernanda I Staquicini, Diana N Nunes, Kisu Kim, Wouter H P Driessen, Amin Hajitou, Lesley C Lomo, Marc Barry, Savitri Krishnamurthy, Aysegul Sahin, Wendy A Woodward, Eric R Prossnitz, Robin L Anderson, Emmanuel Dias-Neto, Ursa A Brown-Glaberman, Melanie E Royce, Naoto T Ueno, Massimo Cristofanilli, Gabriel N Hortobagyi, Serena Marchiò, Juri G Gelovani, Richard L Sidman, Wadih Arap, Renata Pasqualini
Inflammatory breast carcinoma (IBC) is one of the most lethal forms of human breast cancer, and effective treatment for IBC is an unmet clinical need in contemporary oncology. Tumor-targeted theranostic approaches are emerging in precision medicine, but only a few specific biomarkers are available. Here we report up-regulation of the 78-kDa glucose-regulated protein (GRP78) in two independent discovery and validation sets of specimens derived from IBC patients, suggesting translational promise for clinical applications...
October 24, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27784340/il-12-expressing-oncolytic-herpes-simplex-virus-promotes-anti-tumor-activity-and-immunologic-control-of-metastatic-ovarian-cancer-in-mice
#14
Eric D Thomas, Selene Meza-Perez, Kerri S Bevis, Troy D Randall, G Yancey Gillespie, Catherine Langford, Ronald D Alvarez
BACKGROUND: Despite advances in surgical aggressiveness and conventional chemotherapy, ovarian cancer remains the most lethal cause of gynecologic cancer mortality; consequently there is a need for new therapeutic agents and innovative treatment paradigms for the treatment of ovarian cancer. Several studies have demonstrated that ovarian cancer is an immunogenic disease and immunotherapy represents a promising and novel approach that has not been completely evaluated in ovarian cancer...
October 27, 2016: Journal of Ovarian Research
https://www.readbyqxmd.com/read/27775709/rna-binding-protein-cpeb1-remodels-host-and-viral-rna-landscapes
#15
Ranjan Batra, Thomas J Stark, Elizabeth Clark, Jean-Philippe Belzile, Emily C Wheeler, Brian A Yee, Hui Huang, Chelsea Gelboin-Burkhart, Stephanie C Huelga, Stefan Aigner, Brett T Roberts, Tomas J Bos, Shashank Sathe, John Paul Donohue, Frank Rigo, Manuel Ares, Deborah H Spector, Gene W Yeo
Host and virus interactions occurring at the post-transcriptional level are critical for infection but remain poorly understood. Here, we performed comprehensive transcriptome-wide analyses revealing that human cytomegalovirus (HCMV) infection results in widespread alternative splicing (AS), shortening of 3' untranslated regions (3' UTRs) and lengthening of poly(A)-tails in host gene transcripts. We found that the host RNA-binding protein CPEB1 was highly induced after infection, and ectopic expression of CPEB1 in noninfected cells recapitulated infection-related post-transcriptional changes...
December 2016: Nature Structural & Molecular Biology
https://www.readbyqxmd.com/read/27759701/concomitant-cutaneous-langerhans-cell-hystiocytosis-and-leukemia-cutis
#16
Sergio Pina-Oviedo, Carlos A Torres-Cabala, Roberto N Miranda, Michael T Tetzlaff, Selina Singh, Ronald P Rapini, Victor G Prieto, Phyu P Aung
Leukemia cutis develops in <4% of all acute leukemias. Concurrent acute myeloid leukemia (AML) and Langerhans cell histiocytosis (LCH) is rare, with most cases involving lymph nodes or spleen, and no cutaneous involvement. We report the case of a 59-year-old man who presented with fever, malaise, and fatigue. The CBC showed leukocytosis (30.4 × 10/L, 9% blasts), anemia, and thrombocytopenia. Bone marrow biopsy was diagnosed with AML, not otherwise specified, with mutations of FLT3 and IDH2 (R140Q). The patient developed skin rash on the right flank with the clinical differential diagnosis of herpes simplex virus or varicella-zoster virus infection/reactivation versus leukemia cutis...
October 18, 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/27752180/-panuveitis-with-oral-and-genital-ulcer-misdiagnosed-as-behcet-s-disease-two-cases-report-and-literature-review
#17
Y Wang, L Yang, Z L Zhang
Here we reported two patients who presented with panuveitis and were transferred from ophthalmologists to rheumatologists, for both the patients had oral and genital ulcers. They were misdiagnosed with Behcet's disease at first glance. Two young males presented with acute uveitis with history of recurrent oral and genital ulcers. They initially presented with symptoms and signs resembling Behcet's disease and were treated with systemic steroids with suboptimal responses. Routine laboratory test revealed syphilis and human immunodeficiency virus (HIV) infection...
October 18, 2016: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/27639955/generation-and-characterization-of-eptesicus-fuscus-big-brown-bat-kidney-cell-lines-immortalized-using-the-myotis-polyomavirus-large-t-antigen
#18
Arinjay Banerjee, Noreen Rapin, Megan Miller, Philip Griebel, Yan Zhou, Vincent Munster, Vikram Misra
It is speculated that bats are important reservoir hosts for numerous viruses, with 27 viral families reportedly detected in bats. Majority of these viruses have not been isolated and there is little information regarding their biology in bats. Establishing a well-characterized bat cell line supporting the replication of bat-borne viruses would facilitate the analysis of virus-host interactions in an in vitro model. Currently, few bat cell lines have been developed and only Tb1-Lu, derived from Tadarida brasiliensis is commercially available...
November 2016: Journal of Virological Methods
https://www.readbyqxmd.com/read/27622024/investigating-potential-exogenous-tumor-initiating-and-promoting-factors-for-cutaneous-t-cell-lymphomas-ctcl-a-rare-skin-malignancy
#19
REVIEW
Ivan V Litvinov, Anna Shtreis, Kenneth Kobayashi, Steven Glassman, Matthew Tsang, Anders Woetmann, Denis Sasseville, Niels Ødum, Madeleine Duvic
Most skin malignancies are caused by external and often preventable environmental agents. Multiple reports demonstrated that cutaneous T-cell lymphomas (CTCL) can occur in married couples and cluster in families. Furthermore, recent studies document geographic clustering of this malignancy in Texas as well as in other areas of the United States. Multiple infectious, occupational, and medication causes have been proposed as triggers or promoters of this malignancy including hydrochlorothiazide diuretics, Staphylococcus aureus, dermatophytes, Mycobacterium leprae, Chlamydia pneumoniae, human T-Cell lymphotropic virus type 1 (HTLV1), Epstein-Barr virus (EBV), and herpes simplex virus (HSV)...
July 2016: Oncoimmunology
https://www.readbyqxmd.com/read/27604476/gag-mimetic-functionalised-solid-and-mesoporous-silica-nanoparticles-as-viral-entry-inhibitors-of-herpes-simplex-type-1-and-type-2-viruses
#20
Edward C Lee, Nicholas Davis-Poynter, Chau T H Nguyen, Amelia A Peters, Gregory R Monteith, Ekaterina Strounina, Amirali Popat, Benjamin P Ross
A glycosaminoglycan mimetic was attached to the surface of solid and mesoporous silica nanoparticles to create novel antiviral agents against herpes simplex type 1 and type 2 viruses. The nanoparticles act as viral entry inhibitors that appear to block viral attachment and penetration into susceptible cells.
September 28, 2016: Nanoscale
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