Yaseen A Al-Soud, Sondos O Al-Sawakhnah, Raed A Al-Qawasmeh, Najim A Al-Masoudi, Ala'a H Al-Ahmad, Lamiaa Al-Maliki, Lasse van Geelen, Rainer Kalscheuer, Bahjat A Saeed, Amneh Shtaiwi, Holger Stark
A new series of 4-nitroimidazole bearing aryl piperazines 7-16 , tetrazole 17 and 1,3,4-thiadiazole 18 derivatives was synthesized. All derivatives were screened for their anticancer activity against eight diverse human cancer cell lines (Capan-1, HCT-116, LN229, NCI-H460, DND-41, HL-60, K562, and Z138). Compound 17 proved the most potent compound of the series inhibiting proliferation of most of the selected human cancer cell lines with IC50 values in the low micromolar range. In addition, compound 11 exhibited IC50 values ranging 8...
April 8, 2024: Zeitschrift Für Naturforschung. C, A Journal of Biosciences