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https://www.readbyqxmd.com/read/28214774/multimodality-imaging-of-bone-marrow-derived-dendritic-cell-migration-and-antitumor-immunity
#1
Su-Bi Ahn, Sang Bong Lee, Thoudam Debraj Singh, Sung Jin Cho, Sang Kyoon Kim, In-Kyu Lee, Shin Young Jeong, Byeong-Cheol Ahn, Jaetae Lee, Sang-Woo Lee, Yong Hyun Jeon
Here, we sought to monitor bone marrow-derived dendritic cell (BMDC) migration and antitumor effects using a multimodal reporter imaging strategy in living mice. BMDCs were transduced with retroviral vector harboring human sodium iodide symporter (hNIS, nuclear imaging reporter), firefly luc2 (optical imaging reporter), and thy1.1 (surrogate marker of NIS and luc2) genes (BMDC/NF cells). No significant differences in biological functions, including cell proliferation, antigen uptake, phenotype expression, and migration ability, were observed between BMDC and BMDC/NF cells...
February 16, 2017: Translational Oncology
https://www.readbyqxmd.com/read/28208099/the-impact-of-walking-while-using-a-smartphone-on-pedestrians-awareness-of-roadside-events
#2
Ming-I Brandon Lin, Yu-Ping Huang
Previous studies have shown that using a cell phone to talk or text while walking changes gait kinematics and encourages risky street-crossing behaviors. However, less is known about how the motor-cognitive interference imposed by smartphone tasks affects pedestrians' situational awareness to environmental targets relevant to pedestrian safety. This study systematically investigated the influence of smartphone use on detection of and responses to a variety of roadside events in a semi-virtual walking environment...
February 13, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28206841/stressors-and-protective-factors-among-veterinary-students-in-new-zealand
#3
Jenny F Weston, Dianne Gardner, Polly Yeung
A study was undertaken to investigate the stressors faced by veterinary students and the protective factors against those stressors. The study was conducted as a workshop during which students collaborated with their peers through an iterative process to identify personal and external factors that contributed to or protected against stress as a veterinary student, and then to suggest strategies that would protect their mental health and well-being. Workload and assessment were the most commonly reported stressors...
2017: Journal of Veterinary Medical Education
https://www.readbyqxmd.com/read/28199915/rumination-s-effect-on-suicide-ideation-through-grit-and-gratitude-a-path-analysis-study
#4
Evan J White, Morganne A Kraines, Raymond P Tucker, LaRicka R Wingate, Tony T Wells, DeMond M Grant
The current study documents the relationship between suicide ideation, grit and gratitude, and rumination subtypes of brooding and reflection. The relationship between rumination and suicide ideation has been well documented and previous research has demonstrated that grit and gratitude are protective factors against suicide. We hypothesized that both subtypes of rumination would have an indirect effect on suicide ideation through levels of grit and gratitude. Results of a conditional indirect effects path analysis indicated that brooding was indirectly related to suicide ideation through gratitude...
January 31, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28190394/neuroprotective-effect-of-atremorine-in-an-experimental-model-of-parkinson%C3%A2-s-disease
#5
Ivan Carrera, Lucia Fernandez-Novoa, Carolina Sampedro, Ramon Cacabelos
Parkinsonian-like state was generated in mice by the administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to study the effects of Atremorine in Parkinson's disease (PD) related neuropathology and behavior deficits. This devastating disease is caused by the progressive degeneration of dopaminergic neurons in the substantia nigra. Numerous therapeutic strategies have been developed to protect neuronal damage, although no effective treatment for PD has been validated yet. This study tested the preventive and therapeutic neuroprotective effect of Atremorine on MPTP parkinsonian mouse model...
February 10, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28187512/a-review-of-gradient-stiffness-hydrogels-used-in-tissue-engineering-and-regenerative-medicine
#6
REVIEW
Xia Tingting, Liu Wanqian, Yang Li
Substrate stiffness is known to impact characteristics including cell differentiation, proliferation, migration and apoptosis. Hydrogels are polymeric materials distinguished by high water content and diverse physical properties. Gradient stiffness hydrogels are designed by the need to develop biologically friendly materials as extracellular matrix (ECM) alternatives to replace the separated and narrow-ranged hydrogel substrates. Important new discoveries in cell behaviors have been realized with model gradient stiffness hydrogel systems from the two-dimensional (2D) to three-dimensional (3D) scale...
February 10, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28183303/usefulness-of-an-educational-lecture-focusing-on-improvement-in-public-awareness-of-and-attitudes-toward-depression-and-its-treatments
#7
Takashi Yakushi, Teizo Kuba, Yuzuru Nakamoto, Hiroshi Fukuhara, Munenaga Koda, Osamu Tanaka, Tsuyoshi Kondo
BACKGROUND: There is an urgent need to establish effective strategies for suicide prevention. Stigma against depression may be a potential anti-protective factor for suicide. Thus, we investigated baseline levels of awareness and attitudes toward depression and its treatment among the general population by our original 18-item questionnaire, which we aimed to validate in the present study. Next, we conducted two types of educational interventions and examined the results to clarify the difference in the quality of these lectures...
February 10, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28181797/a-thermosensitive-heparin-poloxamer-hydrogel-bridge-afgf-to-treat-spinal-cord-injury
#8
Qingqing Wang, Yan He, Yingzheng Zhao, Huixu Xie, Qian Lin, Zili He, Xiaoyan Wang, Jiawei Li, Hongyu Zhang, Chenggui Wang, Fanghua Gong, Xiaokun Li, Huazi Xu, Qingsong Ye, Jian Xiao
Acidic fibroblast growth factor (aFGF) exerts a protective effect on spinal cord injury (SCI) but is limited by the lack of physicochemical stability andthe ability to cross the blood spinal cord barrier (BSCB). As promising biomaterials, hydrogels contain substantial amounts of water and a 3D porous structureand are commonly used to load and deliver growth factors. Heparin can not only enhance growth factor loading onto hydrogels but also can stabilize the structure and control the release behavior. Herein, a novel aFGF-loaded thermosensitive heparin-poloxamer (aFGF-HP) hydrogel was developed and applied to provide protection and regeneration after SCI...
February 9, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28178181/inside-honeybee-hives-impact-of-natural-propolis-on-the-ectoparasitic-mite-varroa-destructor-and-viruses
#9
Nora Drescher, Alexandra-Maria Klein, Peter Neumann, Orlando Yañez, Sara D Leonhardt
Social immunity is a key factor for honeybee health, including behavioral defense strategies such as the collective use of antimicrobial plant resins (propolis). While laboratory data repeatedly show significant propolis effects, field data are scarce, especially at the colony level. Here, we investigated whether propolis, as naturally deposited in the nests, can protect honeybees against ectoparasitic mites Varroa destructor and associated viruses, which are currently considered the most serious biological threat to European honeybee subspecies, Apis mellifera, globally...
February 6, 2017: Insects
https://www.readbyqxmd.com/read/28177574/characterization-of-protein-interactions-with-molecularly-imprinted-hydrogels-that-possess-engineered-affinity-for-high-isoelectric-point-biomarkers
#10
John R Clegg, Justin X Zhong, Afshan S Irani, Joann Gu, David S Spencer, Nicholas A Peppas
Molecularly imprinted polymers (MIPs) with selective affinity for protein biomarkers could find extensive utility as environmentally robust, cost-efficient biomaterials for diagnostic and therapeutic applications. In order to develop recognitive, synthetic biomaterials for prohibitively expensive protein biomarkers, we have developed a molecular imprinting technique that utilizes structurally similar, analogue proteins. Hydrogel microparticles synthesized by molecular imprinting with trypsin, lysozyme, and cytochrome c possessed an increased affinity for alternate high isoelectric point biomarkers both in isolation and plasma-mimicking adsorption conditions...
February 8, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28177549/factors-relating-to-professional-self-concept-among-nurse-managers
#11
Filiz Kantek, Belkıs Şimşek
AIMS AND OBJECTIVES: his study aims to investigate the self concept in nurse managers in Turkey and the effects of certain variables on professional self concept. BACKGROUND: Professional self concept plays a significant role in improving certain professional behaviors. Nursing managers have the potential to influence other members of the profession with their attitudes and behaviors. DESIGN: The study was designed as a cross-sectional descriptive study...
February 8, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28177188/management-of-hepatic-angiomyolipoma-a-systematic-review
#12
Anne J Klompenhouwer, Danielle Verver, Shiromani Janki, Wichor M Bramer, Michail Doukas, Roy S Dwarkasing, Robert A de Man, Jan N M IJzermans
BACKGROUND & AIMS: Hepatic Angiomyolipoma (HAML) is a rare mesenchymal liver tumor assumed to be predominantly benign, although incidental cases with malignant behavior such as invasive growth, recurrence after resection and metastases have been reported. The aim of this systematic review was to assess the biological behavior, estimate the risk of HAML related mortality and recommend on a justifiable management strategy. METHODS: We performed a systematic literature search in Embase, Medline, Web-of-Science, Scopus, Pubmed Publisher, Cochrane and Google Scholar...
February 8, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28177160/learning-new-sequential-stepping-patterns-requires-striatal-plasticity-during-the-earliest-phase-of-acquisition
#13
Toru Nakamura, Masatoshi Nagata, Takeshi Yagi, Ann M Graybiel, Tetsuo Yamamori, Takashi Kitsukawa
Animals including humans execute motor behavior to reach their goals. For this purpose, they must choose correct strategies according to environmental conditions and shape many parameters of their movements, including their serial order and timing. To investigate the neurobiology underlying such skills, we used a multi-sensor equipped, motor-driven running wheel with adjustable sequences of foothold pegs on which mice ran to obtain water reward. When the peg patterns changed from a familiar pattern to a new pattern, the mice had to learn and implement new locomotor strategies in order to receive reward...
February 8, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28173688/meeting-recommended-levels-of-physical-activity-in-relation-to-preventive-health-behavior-and-health-status-among-adults
#14
Peter D Hart, Gabriel Benavidez, James Erickson
Objectives: The purpose of this study was to examine the relationship of meeting the recommended levels of physical activity (PA) with health status and preventive health behavior in adults. Methods: A total of 5630 adults 18 years of age or older were included in this study. PA was assessed using a series of questions that categorized activities based on their metabolic equivalent values and then categorized individuals based on the reported frequency and duration of such activities...
January 2017: Journal of Preventive Medicine and Public Health, Yebang Ŭihakhoe Chi
https://www.readbyqxmd.com/read/28161900/reduced-chromatin-acetylation-of-malignant-salivary-gland-tumors-correlates-with-enhanced-proliferation
#15
Vivian Petersen Wagner, Manoela Domingues Martins, Douglas Magno Guimaraes, Artur Cunha Vasconcelos, Luise Meurer, Pablo Agustin Vargas, Felipe Paiva Fonseca, Cristiane Helena Squarize, Rogerio Moraes Castilho
BACKGROUND: Epigenetic changes refer to any heritable modification in gene expression independent of alterations in the DNA sequence. Currently, it is well established that epigenetics represents a crucial player for tumor development. Nevertheless, the epigenetic mechanisms involved in the development and progression of salivary gland tumors (SGTs) remain poorly understood. METHODS: In the present study, we analyzed the pattern of acetyl-histone H3 (lys9) expression in benign and malignant SGTs and further correlate our results with tumors' proliferative activity and clinical outcomes...
February 4, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28161584/analytical-and-numerical-modeling-of-the-hearing-system-advances-towards-the-assessment-of-hearing-damage
#16
REVIEW
Annalisa De Paolis, Marom Bikson, Jeremy T Nelson, J Alexander de Ru, Mark Packer, Luis Cardoso
Hearing is an extremely complex phenomenon, involving a large number of interrelated variables that are difficult to measure in vivo. In order to investigate such process under simplified and well-controlled conditions, models of sound transmission have been developed through many decades of research. The value of modeling the hearing system is not only to explain the normal function of the hearing system and account for experimental and clinical observations, but to simulate a variety of pathological conditions that lead to hearing damage and hearing loss, as well as for development of auditory implants, effective ear protections and auditory hazard countermeasures...
February 1, 2017: Hearing Research
https://www.readbyqxmd.com/read/28161525/racial-ethnic-differences-in-young-women-s-health-promoting-strategies-to-reduce-vulnerability-to-sexually-transmitted-infections
#17
Danielle Cipres, Amanda Rodriguez, Janette Alvarez, Lisa Stern, Jody Steinauer, Dominika Seidman
PURPOSE: Young women of color in the United States are disproportionately affected by sexually transmitted infections (STIs). We characterize the protective behaviors used by young women to reduce their vulnerability to STI acquisition and examine how STI prevention strategies differ by race/ethnicity. METHODS: From 2015 to 2016, women aged 13-24 years presenting to five Northern California family planning clinics were surveyed about their STI prevention strategies...
February 1, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/28138827/improving-receipt-and-preventive-care-delivery-for-adolescents-and-young-adults-initial-lessons-from-top-performing-states
#18
Claire D Brindis, Lauren Twietmeyer, M Jane Park, Sally Adams, Charles E Irwin
Purpose Provisions of the Patient Protection and Affordable Care Act (ACA) of 2010 hold promise for improving access to and receipt of preventive services for adolescents and young adults (AYAs). The Title V Block Grant transformation also includes a focus on improving adolescent preventive care. This brief report describes and discusses an inquiry of promising strategies for improving access and preventive care delivery identified in selected high-performing states. Methods Two data sources were used to identify top-performing states in insurance enrollment and preventive care delivery: National Survey of Children's Health for adolescents (ages 12-17 years) and Behavioral Risk Factors Surveillance System for young adults (ages 18-25 years)...
January 30, 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/28134655/a-central-role-for-r7bp-in-the-regulation-of-itch-sensation
#19
Mritunjay Pandey, Jian-Hua Zhang, Santosh K Mishra, Poorni R Adikaram, Benjamin Harris, John F Kahler, Anna Loshakov, Roxanne Sholevar, Allison Genis, Claire Kittock, Juraj Kabat, Sundar Ganesan, Richard R Neubig, Mark A Hoon, William F Simonds
Itch is a protective sensation producing a desire to scratch. Pathologic itch can be a chronic symptom of illnesses such as uremia, cholestatic liver disease, neuropathies and dermatitis, however current therapeutic options are limited. Many types of cell surface receptors, including those present on cells in the skin, on sensory neurons and on neurons in the spinal cord, have been implicated in itch signaling. The role of G protein signaling in the regulation of pruriception is poorly understood. We identify here two G protein signaling components whose mutation impairs itch sensation...
January 27, 2017: Pain
https://www.readbyqxmd.com/read/28130899/investigating-the-self-protective-potential-of-immobility-in-victims-of-rape
#20
Brooke A de Heer, Lynn C Jones
Using a nationwide sample of reported rape cases collected by the Federal Bureau of Investigation (FBI; 389 victims; 89% stranger rapes), this study investigates assumptions about self-protective behaviors for rape victims. Past research on victim resistance strategies often specifies active resistance as self-protective, inadvertently underestimating the potential for biologically based reactions, such as tonic immobility, to be self-protective as well. Results confirm that rape victims who were verbally and physically immobile during the attack were less likely to be injured and have force used against them...
January 27, 2017: Violence and Victims
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