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Safer drinking

Viswanathan Rajagopalan, Youhua Zhang, Christine Pol, Clifford Costello, Samantha Seitter, Ann Lehto, Olga V Savinova, Yue-Feng Chen, A Martin Gerdes
Background: We have shown that thyroid hormones (THs) are cardioprotective and can be potentially used as safe therapeutic agents for diabetic cardiomyopathy and permanent infarction. However, no reliable, clinically translatable protocol exists for TH treatment of myocardial ischemia-reperfusion (IR) injury. We hypothesized that modified low-dose triiodo-L-thyronine (T3) therapy would confer safe therapeutic benefits against IR injury. Methods: Adult female rats underwent left coronary artery ligation for 60 min or sham surgeries...
2017: Frontiers in Physiology
B Scott-Parker, L Stokes, S Panaho, M Cawkwell, J Caldwell
Objective Drink driving is widely recognised as a major road safety problem. In Australia, health promotion messages encourage monitoring the number of standard drinks consumed prior to driving. The pilot research aimed to investigate commuting behaviour and blood alcohol concentration (BAC) of diners, including intended-drivers, at Sunshine Coast restaurants. Methods Five hundred and forty-four diners (n = 260 males) consented to participate in a brief interview and to use a breathalyser device to measure their BAC...
February 25, 2017: Traffic Injury Prevention
Supamas Napavichayanun, Pornanong Aramwit
Wound healing is a natural process of body reaction to repair itself after injury. Nonetheless, many internal and external factors such as aging, comorbidity, stress, smoking, alcohol drinking, infections, malnutrition, or wound environment significantly affect the quality and speed of wound healing. The unsuitable conditions may delay wound healing process and cause chronic wound or scar formation. Therefore, many researches have attempted to search for agents that can accelerate wound healing with safety and biocompatibility to human body...
March 9, 2017: Journal of Biomaterials Science. Polymer Edition
Randall Jasper, Barbara A Stewart, Andrew Knight
Issue addressed: Recreational fishing, particularly rock fishing, can be dangerous; 30 fatalities were recorded in Western Australia from 2002-2014. This study investigates differences in behaviours and attitudes towards safety among fishers at a fishing fatality 'black spot' in Australia.Methods: A total of 236 fishers were surveyed at Salmon Holes, Western Australia in 2015. Fishers were grouped by country of origin and significant differences among groups for behaviours and attitudes towards personal safety were identified...
January 27, 2017: Health Promotion Journal of Australia
Alan R Clough, Stephen A Margolis, Adrian Miller, Anthony Shakeshaft, Christopher M Doran, Robyn McDermott, Robert Sanson-Fisher, Valmae Ypinazar, David Martin, Jan A Robertson, Michelle S Fitts, Katrina Bird, Bronwyn Honorato, Simon Towle, Caryn West
BACKGROUND: In Australia, 'Alcohol Management Plans' (AMPs) provide the policy infrastructure for State and Commonwealth Governments to address problematic alcohol use among Aboriginal and Torres Strait Islanders. We report community residents' experiences of AMPs in 10 of Queensland's 15 remote Indigenous communities. METHODS: This cross-sectional study used a two-stage sampling strategy: N = 1211; 588 (48%) males, 623 (52%) females aged ≥18 years in 10 communities...
January 10, 2017: BMC Public Health
Justin Knox, Vasu Reddy, Tim Lane, Deborah Hasin, Theo Sandfort
Research studies suggest an association between substance use and sexual risk behavior, but are not completely consistent. The moderating effects of other psychosocial factors might help explain these inconsistencies. The current study therefore assessed whether substance use is associated with sexual risk behavior, and whether this relationship is modified by expectancies about the effects of alcohol, reasons for consuming alcohol, or intentions to engage in safe sex. A cross-sectional survey was conducted among 480 black South African men who have sex with men recruited using respondent-driven sampling...
December 26, 2016: AIDS and Behavior
Zachary Burt, Robert M Njee, Yolanda Mbatia, Veritas Msimbe, Joe Brown, Thomas F Clasen, Hamisi M Malebo, Isha Ray
Almost half of all deaths from drinking microbiologically unsafe water occur in Sub-Saharan Africa. Household water treatment and safe storage (HWTS) systems, when consistently used, can provide safer drinking water and improve health. Social marketing to increase adoption and use of HWTS depends both on the prices of and preferences for these systems. This study included 556 households from rural Tanzania across two low-income districts with low-quality water sources. Over 9 months in 2012 and 2013, we experimentally evaluated consumer preferences for six "low-cost" HWTS options, including boiling, through an ordinal ranking protocol...
January 2017: Social Science & Medicine
William C Goedel, Dustin T Duncan
Background: Geosocial-networking smartphone applications (apps) have been used increasingly by men who have sex with men (MSM) to meet new sexual partners. The purpose of this study was to examine associations between contexts of app use (e.g. using apps when drinking) and condomless anal intercourse among a sample of MSM who use these apps. Methods: MSM (n=174) in New York City were recruited through Grindr, a geosocial-networking app popular among MSM, using broadcast advertisements asking MSM to complete an Internet-based survey about their app use and sexual behaviours...
October 7, 2016: Sexual Health
Karim Adinehvand, Amin Sahebnasagh, Mehdi Hashemi-Tilehnoee
BACKGROUND: According to the world health organization, radon is a leading cause of cancer in various internal organs and should be regarded with concern. OBJECTIVES: The aim of this study is to evaluate the concentration of soluble radon in the drinking water of the city of Aliabad Katoul, Iran. MATERIALS AND METHODS: The radon concentration was measured by using a radon meter, SARAD(TM) model RTM 1688-2, according to accepted standards of evaluation...
July 2016: Iranian Red Crescent Medical Journal
Dominic Conroy, Richard de Visser
BACKGROUND: Evaluations of "the prototypical nondrinker" and of "the prototypical regular drinker" have been demonstrated to hold associations with more harmful drinking behavior, yet the extent to which the relative evaluation of these prototypes is associated with drinking intention remains to be tested. OBJECTIVES: To explore whether relatively unfavorable nondrinker prototypes are associated with increased drinking intention and whether this relationship is moderated by personality variables...
December 5, 2016: Substance Use & Misuse
Shahana Parveen, M Saiful Islam, Momtaz Begum, Mahbub-Ul Alam, Hossain M S Sazzad, Rebeca Sultana, Mahmudur Rahman, Emily S Gurley, M Jahangir Hossain, Stephen P Luby
BACKGROUND: During a fatal Nipah virus (NiV) outbreak in Bangladesh, residents rejected biomedical explanations of NiV transmission and treatment and lost trust in the public healthcare system. Field anthropologists developed and communicated a prevention strategy to bridge the gap between the biomedical and local explanation of the outbreak. METHODS: We explored residents' beliefs and perceptions about the illness and care-seeking practices and explained prevention messages following an interactive strategy with the aid of photos showed the types of contact that can lead to NiV transmission from bats to humans by drinking raw date palm sap and from person-to-person...
2016: BMC Public Health
K Lohit, Chanda Kulkarni, R B Galgali
OBJECTIVE: To examine the factors influencing the pattern and extent of anti-craving medication adherence and drinking outcomes in alcohol-dependent patients. MATERIALS AND METHODS: Demographic data from 102 inpatients were collected at discharge from hospital. The pattern of anti-craving medication, extent of adherence, and drinking outcome was collected at 1(st), 3(rd), 8(th), and 12(th) week follow-up. Patients' self-reported adherence, medication diary, and simplified medication adherence questionnaire were used and data were analyzed using SPSS...
April 2016: Journal of Pharmacology & Pharmacotherapeutics
Michael Goodman, Aleisha Elliott, Stanley Gitari, Philip H Keiser, Lauren A Raimer-Goodman
Water quality is an important determinant of diarrheal illnesses, especially affecting children in sub-Saharan Africa. Orphans and vulnerable children (OVC) in sub-Saharan Africa are at increased risk of poor quality drinking water, and therefore of diarrheal illness. The present study assesses primary drinking water source and typical household water purification among OVC households involved in a multi-sectoral empowerment program in semi-rural Kenya. Findings show water purification practices, but not water source, significantly increase with more time in the program...
June 2016: Journal of Water and Health
Narayan Dutt Pant, Nimesh Poudyal, Shyamal Kumar Bhattacharya
BACKGROUND: Water-related diseases are of great concern in developing countries like Nepal. Every year, there are countless morbidity and mortality due to the consumption of unsafe drinking water. Recently, there have been increased uses of bottled drinking water in an assumption that the bottled water is safer than the tap water and its use will help to protect from water-related diseases. So, the main objective of this study was to analyze the bacteriological quality of bottled drinking water and that of municipal tap water...
2016: Journal of Health, Population, and Nutrition
Cathy Su, Allison J Allum, Yasushi Aizawa, Takamitsu A Kato
Glyceryl glucoside (GG, α-d-glucosyglycerol) is a natural glycerol derivative found in alcoholic drinks. Recently GG has been used as an alternative for glycerol in cosmetic products. However, the safety of using GG is still unclear. Currently, dimethyl sulfoxide (DMSO) and glycerol are wildly used in cryopreservation. Despite GG being a derivative of glycerol, the ability of GG in cryopreservation is still unknown. By using a system of Chinese Hamster Ovary cells (CHO), A549 cells and AG1522 cells, the study examined the cryoprotective effects of DMSO, glycerol and GG...
August 5, 2016: Biochemical and Biophysical Research Communications
Calum Wk Chong, Sarah B Wang, Neeranjali S Jain, Cassandra S Bank, Ravjit Singh, Allan Bank, Ian C Francis, Ashish Agar
BACKGROUND: To compare the agreement between peak intraocular pressures measured through the water drinking test and the supine test, in patients with primary open angle glaucoma. DESIGN: Consecutive, prospective, blinded. PARTICIPANTS: Twenty-one patients from the Glaucoma Unit, Prince of Wales Hospital, Sydney, Australia. METHODS: For the supine test, intraocular pressure was recorded immediately after the patient had lain down and at 20 and 40 min...
December 2016: Clinical & Experimental Ophthalmology
María Del Pilar Ramírez-Góngora, Franklyn Edwin Prieto-Alvarado
Participation in amateur street marathons has become increasingly popular and requires prior individual health risk assessment. The objective was to identify risk factors and readiness in registered runners. This was a cross-sectional study in a random sample (n = 510) of registered amateur runners 18-64 years of age, using a digital survey with IPAQ, Par-Q+, and STEPwise, with an expected physical inactivity rate of 35% (±5%). The study explored physical activity, (binge) alcohol consumption, fruit, vegetable, and salt intake, smoking, and readiness...
2016: Cadernos de Saúde Pública
Shogo Kasuda, Kohei Tatsumi, Yoshihiko Sakurai, Midori Shima, Katsuhiko Hatake
Hemophilia A is an X-linked rescessive bleeding disorder that results from F8 gene aberrations. Previously, we established embryonic stem (ES) cells (tet-226aa/N6-Ainv18) that secrete human factor VIII (hFVIII) by introducing the human F8 gene in mouse Ainv18 ES cells. Here, we explored the potential of cell transplantation therapy for hemophilia A using the ES cells. Transplant tet-226aa/N6-Ainv18 ES cells were injected into the spleens of severe combined immunodeficiency (SCID) mice, carbon tetrachloride (CCl4)-pretreated wild-type mice, and CCl4-pretreated hemophilia A mice...
June 2016: Hematology/oncology and Stem Cell Therapy
Gough Yumu Lui, David Roser, Richard Corkish, Nicholas J Ashbolt, Richard Stuetz
Improvements in point-of-use (POU) drinking water disinfection technologies for remote and regional communities are urgently needed. Conceptually, UV-C light-emitting diodes (LEDs) overcome many drawbacks of low-pressure mercury tube based UV devices, and UV-A or visible light LEDs also show potential. To realistically evaluate the promise of LED disinfection, our study assessed the performance of a model 1.3 L reactor, similar in size to solar disinfection bottles. In all, 12 different commercial or semi-commercial LED arrays (270-740 nm) were compared for their ability to inactivate Escherichia coli K12 ATCC W3110 and Enterococcus faecalis ATCC 19433 over 6h...
May 15, 2016: Science of the Total Environment
Jibran Y Khokhar, Alan I Green
Alcohol use disorder in patients with schizophrenia dramatically worsens their clinical course, and few treatment options are available. Clozapine appears to reduce alcohol use in these patients, but its toxicity limits its use. To create a safer clozapine-like drug, we tested whether the antipsychotic iloperidone, a drug that combines a weak dopamine D2 receptor blockade and a potent norepinephrine alpha-2 receptor blockade would reduce alcohol drinking, and whether its effect on alcohol drinking could be increased if combined with an agent to facilitate norepinephrine activity...
June 2016: Neuropharmacology
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