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Jaw Necrosis

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https://www.readbyqxmd.com/read/29352770/concentration-dependent-effect-of-bleaching-agents-on-the-immunolabeling-of-interleukin-6-interleukin-17-and-cd5-positive-cells-in-the-dental-pulp
#1
F Benetti, J E Gomes-Filho, L L Ferreira, G Sivieri-Araújo, E Ervolino, A L F Briso, L T A Cintra
AIM: To evaluate lymphocyte-like cell activation (CD5-positive cells) and the expression of interleukin (IL)-6 and IL-17 in the pulp after dental bleaching with two concentrations of hydrogen peroxide (H2 O2 ). METHODOLOGY: The right and left maxillary molars from 40 rats were treated randomly with bleaching gel with 20% H2 O2 (BLUE group, 1 application of 50 min), 35% H2 O2 (MAXX group, 3 applications of 15 min), or placebo gel (Control). After 2 and 30 days, the rats were killed (n=10), and the jaws were processed for histological and immunohistochemistry analysis of the pulp tissue...
January 20, 2018: International Endodontic Journal
https://www.readbyqxmd.com/read/29303860/mandibular-osteonecrosis-associated-with-raloxifene
#2
Hélder Antônio Rebelo Pontes, Lucas Lacerda de Souza, Daniel Cavalléro Colares Uchôa, João Mateus Mendes Cerqueira
Osteonecrosis is a disease with diverse pathophysiology, clinical presentation, and management. It may be associated with some medications used to treat systemic issues with bone metabolism. A few cases of jaw bone osteonecrosis have been associated with raloxifene. In this paper, the authors present a clinical report of a 64-year-old woman who presented with a necrosis foci in the right alveolar ridge of the mandible, associated with continued raloxifene use.
January 4, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29233701/in%C3%A2-vivo-effects-of-geranylgeraniol-on-the-development-of-bisphosphonate-related-osteonecrosis-of-the-jaws
#3
Filip Koneski, Danica Popovic-Monevska, Icko Gjorgoski, Jovanka Krajoska, Mirjana Popovska, Ilijana Muratovska, Boris Velickovski, Gordana Petrushevska, Vladimir Popovski
BACKGROUND: Bisphosphonate-related osteonecrosis of the jaws (BRONJ) is a complication of the bisphosphonate (BP) treatment and its pathopysiology is still not fully understood. The existing preventive and treatment options require updates and more attention. Geranylgeraniol (GGOH) so far demonstrated an increased activity and viability of the cells previously treated with zoledronic acid (ZA). The aim of this study was to evaluate the in vivo effects of GGOH on the development of BRONJ...
November 20, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29215680/effects-of-zoledronic-acid-in-experimental-periapical-lesions-in-rats-an-imaging-and-histological-analysis
#4
Talita Ribeiro Tenório de França, Flávia Maria de Moraes Ramos-Perez, Andrea Dos Anjos Pontual, Jurema Freire Lisboa de Castro, Paulo Rogério Ferreti Bonan, Danyel Elias da Cruz Perez
The aim of this study was to assess the imaging and histological features of experimental periapical lesions, including the adjacent alveolar bone, in rats under zoledronic acid treatment. The study used 40 male Wistar rats distributed into 8 groups of 5 animals each: G1: induction of periapical lesion (PL) and weekly intraperitoneal administration (WIPA) of saline solution (0.9% NaCl) for 4 weeks; G2: PL induction and WIPA of zoledronic acid (0.15 mg/kg/week) for 4 weeks; G3: PL induction and WIPA of saline solution for 8 weeks; G4: PL induction and WIPA of zoledronic acid for 8 weeks; G5:WIPA of saline solution for 4 weeks and subsequent PL induction; G6: WIPA of zoledronic acid for 4 weeks and subsequent PL induction; G7: WIPA of saline solution for 8 weeks and subsequent PL induction; G8: WIPA of zoledronic acid for 8 weeks and subsequent PL induction...
September 2017: Brazilian Dental Journal
https://www.readbyqxmd.com/read/29184499/aliskiren-improves-ischemia-and-oxygen-glucose-deprivation-induced-cardiac-injury-through-activation-of-autophagy-and-amp-activated-protein-kinase
#5
Ming-Hsien Chiang, Chan-Jung Liang, Chen-Wei Liu, Bo-Jhih Pan, Wen-Ping Chen, Yi-Fan Yang, I-Ta Lee, Jaw-Shiun Tsai, Chiang-Wen Lee, Yuh-Lien Chen
Aliskiren is a direct renin inhibitor that has been effective in anti-hypertension. We investigated whether aliskiren could improve the ischemia-induced cardiac injury and whether the autophagy was involved in this effect. A myocardial infarction (MI) model was created by the ligation of the left anterior coronary artery in C57J/BL6 mice. They were treated for 1, 3, 7, and 14 days with vehicle or aliskiren (25 mg/kg/day via subcutaneous injection). In vivo, the MI mice exhibited worse cardiac function by echocardiographic assessment and showed larger myocardial scarring by light microscopy, whereas aliskiren treatment reversed these effects, which were also associated with the changes in caspase-3 and Bcl-2 expression as well as in the number of apoptotic cells...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29184447/aseptic-avascular-osteonecrosis-local-silent-inflammation-in-the-jawbone-and-rantes-ccl5-overexpression
#6
Johann Lechner, Sabine Schuett, Volker von Baehr
Of the definitions listed in the International Statistical Classification of Diseases and Related Health Problems, tenth revision (ICD-10), two disease descriptions can be found together: "idiopathic aseptic bone necrosis" and "avascular bone necrosis." The relevant literature on both the conditions abbreviates both as "aseptic ischemic osteonecrosis in the jawbone" (AIOJ). To shed light on the clinical details of this condition, osteolytic jawbone samples of 24 patients with different systemic immunological diseases were examined using four steps: presurgical dental X-ray, postsurgical histology, polymerase chain reaction DNA analysis (PCR DNA) of bacteria, and RANTES/CCL5 (R/C) expression...
2017: Clinical, Cosmetic and Investigational Dentistry
https://www.readbyqxmd.com/read/29169968/evaluation-of-several-clinical-parameters-after-bleaching-with-hydrogen-peroxide-at-different-concentrations-a-randomized-clinical-trial
#7
Suellen Nogueira Linares Lima, Izabella Santos Ribeiro, Marcos Augusto Grisotto, Elizabeth Soares Fernandes, Viviane Hass, Rudys Rodolfo de Jesus Tavarez, Shelon Cristina Souza Pinto, Darlon Martins Lima, Alessandro D Loguercio, Matheus Coelho Bandeca
OBJECTIVE: This randomized double-blind clinical trial compared tooth sensitivity (TS), bleaching efficacy, and cytokine levels after applying in-office bleaching treatments containing 15% and 35% hydrogen peroxide (HP15% and HP35%, respectively). METHODS: Twenty-five volunteers were randomly assigned to receive HP15% or HP35% treatment. The bleaching agent was applied in three 15-minute applications per session. Two bleaching sessions were separated by a 1-week interval...
November 20, 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/29109954/role-of-periapical-diseases-in-medication-related-osteonecrosis-of-the-jaws
#8
Nian Jing Rao, Jing Yi Wang, Ru Qing Yu, Yiu Yan Leung, Li Wu Zheng
Objective: The present study aimed to investigate the role of periapical diseases in inducing medication-related osteonecrosis of the jaws (MRONJ) using an ovariectomized (OVX) mice model. Materials and Methods: Twenty C57BL/6N female mice were randomly assigned to two groups. All mice were subjected to bilateral ovariectomy and then treated with oncologic dose of zoledronic acid (ZA) or vehicle for twelve weeks. Eight weeks after commence of drug administration, a pulpal exposure (PE) operation was performed on the first right lower molar to induce periapical periodontitis; the contralateral non-PE tooth was used as control...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29071028/successful-use-of-lower-level-laser-therapy-in-the-treatment-of-medication-related-osteonecrosis-of-the-jaw
#9
Gustavo Antonio Correa Momesso, Fábio Roberto de Souza Batista, Cecília Alves de Sousa, Valthierre Nunes de Lima, Tárik Ocon Braga Polo, Jaqueline Suemi Hassumi, Idelmo Rangel Garcia Júnior, Leonardo Perez Faverani
Case Presentation: This study aimed to report a case of medication related osteonecrosis of the jaw (MRONJ) of a 65-year-old female patient referred to the Oral and Maxillofacial Surgery team from Araçatuba Dental School, complaining about mobility of a previously dental implant placed on the posterior maxillary region. Clinical examination revealed an extensive necrosis area around the implant region. The patient reported bisphosphonate therapy with sodium alendronate for prevention of osteoporosis 5 years ago...
2017: Journal of Lasers in Medical Sciences
https://www.readbyqxmd.com/read/29063702/antiresorptive-treatment-associated-onj
#10
REVIEW
Evangelos Eleutherakis-Papaiakovou, Aristotelis Bamias
Osteonecrosis of the jaw (ONJ) is a severe complication of therapy with antiresorptive agents (e.g. bisphosphonates and denosumab), which are used to manage bone metastases from cancer, to reduce the incidence of skeletal-related events. Available data indicate that 0-27, 5% of patients exposed to antiresorptive agents may develop ONJ, depending on the number of infusions and the duration of therapy. Besides antiresorptive therapy, a number of risk factors for osteonecrosis have been identified. Oral surgical procedures, tooth extractions and infection to the jawbones are considered the main risk factors for developing ONJ, when receiving antiresorptive therapy...
November 2017: European Journal of Cancer Care
https://www.readbyqxmd.com/read/29030280/mobilization-of-malpositioned-dental-implant-using-segmental-osteotomy-a-case-report
#11
M Gholami
By increasing the number of replaced tooth with dental implants, the number of poorly positioned implants is also increased. In this article, we present our experience about a 48-year-old female who was referred to our department for resolving prosthetic problem regarding two malpositioned implants inserted in the upper jaw. The interocclusal space was insufficient and the two adjacent implants had excessive buccal angulation. To overcome these problems, segmental osteotomy of the alveolar bone containing two implants has been done...
October 10, 2017: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28977694/denosumab-related-osteonecrosis-of-the-jaw-a-retrospective-study
#12
Claire Egloff-Juras, Aurélie Gallois, Julia Salleron, Vincent Massard, Gilles Dolivet, Julie Guillet, Bérengère Phulpin
BACKGROUND: Osteonecrosis of the jaw is a very delicate side effect of Denosumab. The aim of this retrospective study was to assess the occurrence rate of Denosumab-related osteonecrosis of the jaw (DRONJ) at the Cancer Institute of Lorraine (ICL) and to highlight necrosis risk factors. METHODS: To that purpose, we analyzed the medical records of 249 consecutive patients treated with Denosumab at the ICL during the past 5 years. Patients who received orofacial radiotherapy or a previous treatment with a bisphosphonate were excluded...
October 4, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28967493/the-influence-of-adalimumab-on-the-healing-of%C3%A2-apical-periodontitis-in-ferrets
#13
Elisabetta Cotti, Kenneth Abramovitch, James Jensen, Elia Schirru, Dwight D Rice, Udochukwu Oyoyo, Mahmoud Torabinejad
INTRODUCTION: Given the increasing use of anti-tumor necrosis factor α (anti-TNFα) biologic medications, and their interferences with the immune-inflammatory response, this study evaluated the effect of adalimumab (anti-TNFα), on healing and healing time of apical periodontitis (AP) in ferrets. METHODS: Twelve male ferrets received cone beam computed tomography of the jaws at baseline health (T0); AP confirmation (T1); and 30 (T2), 60 (T3), and 90 (T4) days after root canal treatment (RCT) to monitor healing...
November 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28966691/wogonoside-alleviates-inflammation-induced-by-traumatic-spinal-cord-injury-by-suppressing-nf-%C3%AE%C2%BAb-and-nlrp3-inflammasome-activation
#14
Yonglin Zhu, Hanzhong Zhu, Zhaojie Wang, Fengguang Gao, Jingsheng Wang, Wenqiang Zhang
Wogonoside possesses anti-oxidative, anti-inflammatory, anti-allergy and anti-tumor properties. The aim of the present study was to evaluate whether wogonoside alleviates spinal cord injury (SCI)-induced inflammation via nuclear factor (NF)-κB and nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 3 (NLRP3) inflammasome activation. Sprague-Dawley rats were positioned in the jaws of a calibrated aneurysm clip with a closing pressure of 55 g. The jaws were placed on the dorsal and ventral surfaces of the spinal cord and left in place for 1 min...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28935761/impact-of-tnf-308-g-a-rs1800629-gene-polymorphism-in-modulation-of-leprosy-risk-a-reappraise-meta-analysis-of-14-case-control-studies
#15
Mohammed Y Areeshi, Raju K Mandal, Sajad A Dar, Arshad Jawed, Mohd Wahid, Mohtashim Lohani, Aditya K Panda, Bhartendu N Mishra, Naseem Akhter, Shafiul Haque
PURPOSE: Earlier studies have shown that tumor necrosis factor (TNF) -308 G>A (rs1800629) gene polymorphism is implicated in the susceptibility to leprosy, but results were inconsistent. METHODS: A meta-analysis of 14 studies involving 3327 leprosy cases and 3203 controls was performed to appraise the association of TNF -308 G>A polymorphism with leprosy using MEDLINE (PUBMED), EMBASE, and Google Scholar web databases. RESULTS: Overall, no significant association was observed in allelic (A vs...
October 31, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28918879/axitinib-related-osteonecrosis-of-the-jaw
#16
Vinod Patel, Chris Sproat, Jerry Kwok, Nikki Tanna
Tyrosine kinase inhibitors (TKIs) are oral chemotherapy drugs used primarily to treat leukemias, renal cell carcinomas, gastrointestinal stromal tumors, and neuroendocrine tumors. Within this group, a number of drugs have already been implicated in jaw necrosis. Axitinib (Inlyta) is a novel TKI currently licensed for the treatment of renal cell carcinoma. We report the first case, to our knowledge, of jaw necrosis solely related to this medication and review the literature surrounding TKIs and their implication in osteonecrosis of the jaw...
November 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/28803745/further-development-of-the-mronj-minipig-large-animal-model
#17
Sven Otto, Christoph Pautke, Olga Martin Jurado, Dirk Nehrbass, Martin J Stoddart, Michael Ehrenfeld, Stephan Zeiter
Medication-related osteonecrosis of the jaw (MRONJ) is a rare but serious and potentially severe side effect of antiresorptive therapy with bisphosphonates or denosumab. Recently, a large animal minipig MRONJ model was introduced which led to early necrotic lesions in the majority of extraction sites after bisphosphonate administration. The aim of this project was to modify the preoperative cumulative bisphosphonate dose (zoledronate) and hereby firstly to demonstrate the reliability and reproducibility of the established model...
September 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28740273/mandibular-osteonecrosis-due-to-the-pulpal-periodontal-syndrome-a-case-report-and-review-of-the-literature
#18
Dragana Gabrić, Sven Seiwerth, Anja Baraba, Vanja Vučićević, Boras
OBJECTIVE: Ishemic bone disease has multifactorial etiologies. Cronic dental infections should be eliminated to prevent osteonecrosis of the jaw. CASE REPORT: We report an unusual case of osteonecrosis due to the pulpal-peridontal syndrome and subsequent pulp necrosis. A case of 38 year old woman who presented with exposed bone, 8 mm in diameter, in the lingual area of the right lower third molar. The patient was otherwise healthy and was not taking any medications...
March 2017: Acta Stomatologica Croatica
https://www.readbyqxmd.com/read/28715092/the-origins-of-oral-medicine-in-the-hippocratic-collected-works
#19
REVIEW
Helen Askitopoulou, Vasileia Nyktari, Alexandra Papaioannou, Georgios Stefanakis, Elina Konsolaki
The collected works of Hippocrates describe for the first time in a systematic way a large number of oral diseases, such as ulcers, inflammations, abscesses and tumours from the epiglottis, mouth, tongue, palate, uvula and the sublingual area. Several of these case reports are remarkable for the accurate observation of clinical symptoms and signs, the aetiology, the pathogenesis and their therapeutic approach in relation to prognosis. The Hippocratic authors report cases of aphthae as part of a polysystemic disease, described many centuries later by Behçet and Adamantiades, while they associate features of splenomegaly from endemic malaria with gingivitis (ulitis)...
October 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28709454/comparison-of-skin-sparing-mastectomy-using-ligasure%C3%A2-small-jaw-and-electrocautery
#20
Young Woo Chang, Hwan Soo Kim, Seung Pil Jung, Sang Uk Woo, Jae Bok Lee, Jeoung Won Bae, Gil Soo Son
BACKGROUND: Skin-sparing mastectomy (SSM) is increasingly used in patients with breast cancer. We compared the differences between use of electrocautery and LigaSure™ Small Jaw in patients with breast cancer who underwent SSM. METHODS: Between January 2012 and December 2015, 81 patients with breast cancer who underwent SSM were selected and were divided into the electrocautery group and the LigaSure™ Small Jaw group based on the devices that were used. Clinicopathological characteristics, body mass index, operative time, and weight of removed breast were obtained from medical records...
July 14, 2017: World Journal of Surgical Oncology
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