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https://www.readbyqxmd.com/read/28094052/the-association-of-cancer-risks-with-pentachlorophenol-exposure-focusing-on-community-population-in-the-areas-along-certain-section-of-yangtze-river-in-china
#1
Yanjie Cui, Ling Liang, Qi Zhong, Qian He, Xiaomei Shan, Keyang Chen, Fen Huang
Pentachlorophenol (PCP) was used in large quantities, and mainly for killing the intermediate host snails of schistosome in China, thereby resulting in ubiquitous PCP residue in the environment. However, studies considering the carcinogenicity of PCP for humans mainly focused on occupational workers, and the actual carcinogenicity of PCP for general population is uncertain. To investigate the association between cancer risks and PCP exposure in a community population, an ecological study was conducted in three contaminated areas along the Yangtze River...
January 13, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28092725/strontium-ranelate-a-promising-disease-modifying-osteoarthritis-drug
#2
Weiyu Han, Shicai Fan, Xiaochun Bai, Changhai Ding
The articular cartilage and subchondral bone may have potential crosstalk in the development and progression of osteoarthritis (OA). Strontium ranelate (SrR) has the ability to dissociate the bone remodeling process and to change the balance between bone resorption and bone formation. Its effect on subchondral bone makes it a potential disease- modifying osteoarthritis drug (DMOAD) in the treatment of OA. The aim of the current review is to summarize up-to-date pharmacological and clinical data of SrR for OA treatment...
January 16, 2017: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/28078921/regional-differences-in-mortality-hospital-discharges-and-primary-care-contacts-for-cardiovascular-disease
#3
Sigridur Haraldsdottir, Sigurdur Gudmundsson, Guđmundur Thorgeirsson, Sigrun H Lund, Unnur A Valdimarsdottir
AIMS: Surveillance of geographical variations in cardiovascular health is important in order to achieve the objectives of reducing regional health disparities. We aimed to explore differences in cardiovascular disease (CVD) mortality and prevalence of CVD diagnoses made in primary and in-patient care, as well as risk factor distribution by geographic regions (urban/rural) in Iceland. METHODS: From nationwide health registers, we obtained data on CVD mortalities ( N = 7113), primary healthcare CVD contacts ( N = 58,246) and hospital CVD discharges ( N = 14,039), as well as data on CVD risk factors from a national health survey ( N = 5909; response rate 60...
January 1, 2017: Scandinavian Journal of Public Health
https://www.readbyqxmd.com/read/28067550/association-between-consumption-of-soy-and-risk-of-cardiovascular-disease-a-meta-analysis-of-observational-studies
#4
Zhaoli Yan, Xinyue Zhang, Chunlin Li, Shouchun Jiao, Wenyao Dong
Background The relationships between dietary intake of soy foods and risk of cardiovascular disease are uncertain. The aims of this study were to evaluate and summarize the evidence on the association between consumption of soy and risk of cardiovascular disease (including stroke and coronary heart disease). Methods We systematically searched the MEDLINE and EMBASE databases from their inception up to 22 February 2016. We included only observational studies, and used random-effects models to calculate summary relative risks (SRRs) and 95% confidence intervals (CIs)...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28059401/single-sideband-photonic-microwave-generation-with-an-optically-injected-quantum-dot-semiconductor-laser
#5
Chih-Ying Chen, Chih-Hao Cheng, Fan-Yi Lin
We studied single-sideband (SSB) photonic microwave generation with a high sideband rejection ratio (SRR) based on the period-one dynamical states of an optically injected quantum-dot (QD) semiconductor laser and demonstrated that the SSB signals have SRRs of approximately 15 dB higher than those generated with a conventional quantum-well semiconductor laser under conditions of optimal microwave power. The enhancement of SRR in the QD laser, which is important in mitigating the power penalty effect in applications such as radio-over-fiber optical communications, could be primarily attributed to a lower carrier decay rate in the dots, smaller linewidth enhancement factor, and reduced photon decay rate...
December 26, 2016: Optics Express
https://www.readbyqxmd.com/read/28059143/influence-of-coronary-artery-disease-and-subclinical-atherosclerosis-related-polymorphisms-on-the-risk-of-atherosclerosis-in-rheumatoid-arthritis
#6
Raquel López-Mejías, Alfonso Corrales, Esther Vicente, Montserrat Robustillo-Villarino, Carlos González-Juanatey, Javier Llorca, Fernanda Genre, Sara Remuzgo-Martínez, Trinidad Dierssen-Sotos, José A Miranda-Filloy, Marco A Ramírez Huaranga, Trinitario Pina, Ricardo Blanco, Juan J Alegre-Sancho, Enrique Raya, Verónica Mijares, Begoña Ubilla, Iván Ferraz-Amaro, Carmen Gómez-Vaquero, Alejandro Balsa, Francisco J López-Longo, Patricia Carreira, Isidoro González-Álvaro, J Gonzalo Ocejo-Vinyals, Luis Rodríguez-Rodríguez, Benjamín Fernández-Gutiérrez, Santos Castañeda, Javier Martín, Miguel A González-Gay
A genetic component influences the development of atherosclerosis in the general population and also in rheumatoid arthritis (RA). However, genetic polymorphisms associated with atherosclerosis in the general population are not always involved in the development of cardiovascular disease (CVD) in RA. Accordingly, a study in North-American RA patients did not show the association reported in the general population of coronary artery disease with a series of relevant polymorphisms (TCF21, LPA, HHIPL1, RASD1-PEMT, MRPS6, CYP17A1-CNNM2-NT5C2, SMG6-SRR, PHACTR1, WDR12 and COL4A1-COL4A2)...
January 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28052066/effects-of-strontium-ranelate-on-spinal-interbody-fusion-surgery-in-an-osteoporotic-rat-model
#7
Tsung-Ting Tsai, Ching-Lung Tai, Natalie Yi-Ju Ho, Po-Liang Lai, Tsai-Sheng Fu, Chi-Chien Niu, Lih-Huei Chen, Wen-Jer Chen
Osteoporosis is a bone disease that afflicts millions of people around the world, and a variety of spinal integrity issues, such as degenerative spinal stenosis and spondylolisthesis, are frequently concomitant with osteoporosis and are sometimes treated with spinal interbody fusion surgery. Previous studies have demonstrated the efficacy of strontium ranelate (SrR) treatment of osteoporosis in improving bone strength, promoting bone remodeling, and reducing the risk of fractures, but its effects on interbody fusion surgery have not been adequately investigated...
2017: PloS One
https://www.readbyqxmd.com/read/28000770/angle-and-polarization-insensitive-metamaterial-absorber-using-via-array
#8
Daecheon Lim, Dongju Lee, Sungjoon Lim
In this paper, we propose an angle- and polarization-insensitive metamaterial absorber. We design a metamaterial unit cell that is based on a split ring cross resonator (SRCR). We observe that the absorption frequency and absorption ratio are insensitive to incident angles when a via array surrounds the SRR. We demonstrate the effect of the via array using full-wave simulations by comparing the absorptivity of the SRCR with and without the via array. Because of the symmetric geometry, we also realize polarization insensitivity...
December 21, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27995560/racial-disparities-in-above-knee-amputations-after-tka-a-national-database-study
#9
Jaiben George, Suparna M Navale, Nicholas K Schiltz, Miguel Siccha, Alison K Klika, Carlos A Higuera
BACKGROUND: Above-knee amputation (AKA) is a rare but devastating complication of TKA. Although racial disparities have been previously reported in the utilization of TKA, it is unclear whether disparities exist in the rates of AKA after TKA. QUESTIONS/PURPOSES: (1) Which gender-racial group has the highest rate of AKA from septic and aseptic complications of TKA? (2) Which age groups have higher rates of AKA from septic and aseptic complications of TKA? METHODS: Using National Inpatient Sample data from 2000 to 2011, AKAs resulting from complications of TKA were identified using a combination of International Classification of Diseases, 9th Revision procedure and diagnosis codes...
December 19, 2016: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/27994515/dose-dependent-effects-of-strontium-ranelate-on-ovariectomy-rat-bone-marrow-mesenchymal-stem-cells-and-human-umbilical-vein-endothelial-cells
#10
Xiaojing Guo, Silong Wei, Mengmeng Lu, Zhengwei Shao, Jiayu Lu, Lunguo Xia, Kaili Lin, Derong Zou
In clinic, strontium ranelate (SrR) is a useful drug to treat osteoporosis by orally taken method, but some side effect appeared in recent years. The aim of this study is to evaluate the effectiveness and safety of SrR on cells by direct application, to study the possibility of local application of this drug. Qualitative ALP staining, quantitative ALP activity assay, alizarin red staining, realtime PCR and westernblot assay were used to evaluate the osteogenesis ability of SrR under normal or osteogenic induction environment of ovariectomy bone marrow mesenchymal stem cells (OVX-BMSCs)...
2016: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/27978606/level-of-genetic-differentiation-affects-relative-performances-of-est-and-genomic-ssrs
#11
Aurélie Khimoun, Anthony Ollivier, Bruno Faivre, Stéphane Garnier
Microsatellites, also called simple sequence repeats (SSRs) are markers of choice to estimate relevant parameters for conservation genetics, such as migration rates, effective population size and kinship. Cross-amplification of SSRs is the simplest way to obtain sets of markers and highly conserved SSRs have recently been developed from Expressed Sequence Tags (EST) to improve SRR cross-species utility. As EST-SSRs are located in coding regions, the higher stability of their flanking regions reduces the frequency of null alleles and improves cross-species amplification...
December 15, 2016: Molecular Ecology Resources
https://www.readbyqxmd.com/read/27927192/daily-milk-consumption-and-all-cause-mortality-coronary-heart-disease-and-stroke-a-systematic-review-and-meta-analysis-of-observational-cohort-studies
#12
Patrick Mullie, Cécile Pizot, Philippe Autier
BACKGROUND: Observational studies and meta-analyses relating milk consumption by adults to all-cause mortality, coronary heart disease and stroke have obtained contradictory results. Some studies found a protective effect of milk consumption, whilst other found an increased risk. METHODS: We performed a systematic literature search until June 2015 on prospective studies that looked at milk consumption, all-cause mortality, coronary heart disease and stroke. Random-effect meta-analyses were performed with dose-response...
December 8, 2016: BMC Public Health
https://www.readbyqxmd.com/read/27917167/potential-for-sulfate-reduction-in-mangrove-forest-soils-comparison-between-two-dominant-species-of-the-americas
#13
Melike Balk, Joost A Keuskamp, Hendrikus J Laanbroek
Avicennia and Rhizophora are globally occurring mangrove genera with different traits that place them in different parts of the intertidal zone. It is generally accepted that the oxidizing capacity of Avicennia roots is larger than that of Rhizophora roots, which initiates more reduced conditions in the soil below the latter genus. We hypothesize that the more reduced conditions beneath Rhizophora stands lead to more active sulfate-reducing microbial communities compared to Avicennia stands. To test this hypothesis, we measured sulfate reduction traits in soil samples collected from neighboring Avicennia germinans and Rhizophora mangle stands at three different locations in southern Florida...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27906284/electrically-reconfigurable-split-ring-resonator-covered-by-nematic-liquid-crystal-droplet
#14
Kepeng Qiu, Ning Jia, Zijun Liu, Chen Wu, Yuancheng Fan, Quanhong Fu, Fuli Zhang, Weihong Zhang
In this paper, an electrically reconfigurable split ring resonator (SRR) covered by sessile droplet of nematic liquid crystal (LC) is demonstrated experimentally. The magnetic resonance of single SRR decreases gradually by 237 MHz as external bias voltage is applied, resulting from increasing fringing capacitance due to liquid crystal molecular reorientation along local electric field distribution. The transmission phase can be modulated by more than 100 degrees. Furthermore, frequency tuning range of SRR increases with the droplet height, because of the significant enhancement for SRR capacitance difference between LC states with/without bias voltage...
November 28, 2016: Optics Express
https://www.readbyqxmd.com/read/27880078/serine-racemase-is-expressed-in-islets-and-contributes-to-the-regulation-of-glucose-homeostasis
#15
Amber D Lockridge, Daniel C Baumann, Brian Akhaphong, Alleah Abrenica, Robert F Miller, Emilyn U Alejandro
NMDA receptors (NMDARs) have recently been discovered as functional regulators of pancreatic β-cell insulin secretion. While these excitatory receptor channels have been extensively studied in the brain for their role in synaptic plasticity and development, little is known about how they work in β-cells. In neuronal cells, NMDAR activation requires the simultaneous binding of glutamate and a rate-limiting co-agonist, such as D-serine. D-serine levels and availability in most of the brain rely on endogenous synthesis by the enzyme serine racemase (Srr)...
November 2016: Islets
https://www.readbyqxmd.com/read/27769678/serine-rich-repeat-adhesin-gordonii-surface-protein-b-is-important-for-streptococcus-gordonii-biofilm-formation
#16
A Reum Kim, Ki Bum Ahn, Hyun Young Kim, Ho Seong Seo, Cheol-Heui Yun, Seung Hyun Han
INTRODUCTION: Streptococcus gordonii is a predominant member of the oral microflora and has been isolated from root canals of teeth with refractory apical periodontitis. Biofilm formation is important for various dental diseases, and S. gordonii is involved in dental biofilm formation as an early colonizer. Although serine-rich repeat (SRR) adhesins of S. gordonii such as gordonii surface protein B (GspB) are associated with bacterial colonization, the role of GspB in biofilm formation is not clearly understood...
December 2016: Journal of Endodontics
https://www.readbyqxmd.com/read/27765402/type-2-diabetes-and-gender-differences-in-liver-cancer-by-considering-different-confounding-factors-a-meta-analysis-of-cohort-studies
#17
Yuqin Wang, Baochan Wang, Shiyan Yan, Feng Shen, Haixia Cao, Jiangao Fan, Rongrong Zhang, Jun Gu
PURPOSE: Questions remain uncertainty regarding the gender differences in the relationship between type 2 diabetes (T2DM) and liver cancer risk. By considering several confounding factors, we aimed to identify this issue according to a meta-analysis of cohort studies. METHODS: We searched EMBASE and MEDLINE for studies on the association between T2DM and risk of liver cancer up to November 30, 2014. A random-effects model was performed to calculate summary relative risks (SRRs) with corresponding 95% confidence intervals (CIs)...
September 22, 2016: Annals of Epidemiology
https://www.readbyqxmd.com/read/27750167/mercury-methylation-and-sulfate-reduction-rates-in-mangrove-sediments-rio-de-janeiro-brazil-the-role-of-different-microorganism-consortia
#18
Raquel Rose Silva Correia, Jean Remy Davée Guimarães
Recent studies have shown Hg methylation in mangrove sediments, however, little is known about the different microorganism consortia involved. We investigated the participation of prokaryotes in general, iron-reducing bacteria-IRB, sulfate-reducing bacteria-SRB, methanogens and fungi in Hg methylation and sulfate reduction rates (SRR) in mangrove sediments using iron amendments for IRB and specific inhibitors for the other microorganisms. Sediment samples were collected from two mangrove zones, tidal flat and mangrove forest (named root sediments)...
January 2017: Chemosphere
https://www.readbyqxmd.com/read/27747739/injury-risk-in-british-columbia-canada-1986-to-2009-are-aboriginal-children-and-youth-over-represented
#19
M Anne George, Andrew Jin, Mariana Brussoni, Christopher E Lalonde, Rod McCormick
BACKGROUND: Children and youth worldwide are at high risk of injury resulting in morbidity, disability or mortality. Disparities in risk exist between and within countries, and by sex and ethnicity. Our aim is to contribute data on disparities of injury rates for Aboriginal children and youth compared with those of the general population in British Columbia (BC), Canada, by examining risks for the two populations, utilizing provincial administrative data over a 24-year period. METHODS: Hospital discharge records from the provincial health care database for children and youth were used to identify injury for the years 1986 to 2009...
December 2015: Injury Epidemiology
https://www.readbyqxmd.com/read/27736623/impact-of-the-australian-national-cervical-screening-program-in-women-of-different-ages
#20
Megan Smith, Karen Canfell
OBJECTIVES: The Australian National Cervical Screening Program (NCSP) will transition in 2017 from cytology-based screening every two years, starting from age 18-20 years, to HPV-based screening every 5 years, starting from age 25. To examine the impact of the program before this transition we analysed trends in the incidence of cervical cancer, by age and histological subtype. DESIGN, SETTING AND PARTICIPANTS: National cervical cancer incidence data, 1982-2010...
October 17, 2016: Medical Journal of Australia
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