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Sara Gandini, Giovanna Masala, Domenico Palli, Benedetta Cavicchi, Calogero Saieva, Ilaria Ermini, Federica Baldini, Patrizia Gnagnarella, Saverio Caini
PURPOSE: Several studies in recent years have investigated the relationship between alcohol intake and melanoma risk, with conflicting results. To help clarify this issue, we conducted a literature review and dose-response meta-analysis of studies published until June 30th, 2017, that examined the association between alcohol intake (overall and by beverage type) and melanoma risk. METHODS: We used random effect models with maximum likelihood estimation to calculate summary relative risk (SRR) and 95% confidence intervals (95%CI)...
January 11, 2018: European Journal of Nutrition
Yan Cui, William F Delaney, Taghi Darroudi, Pingshan Wang
A microwave technique is demonstrated to measure floating giant unilamellar vesicle (GUV) membranes in a 25 μm wide and 18.8 μm high microfluidic channel. The measurement is conducted at 2.7 and 7.9 GHz, at which a split-ring resonator (SRR) operates at odd modes. A 500 nm wide and 100 μm long SRR split gap is used to scan GUVs that are slightly larger than 25 μm in diameter. The smaller fluidic channel induces flattened GUV membrane sections, which make close contact with the SRR gap surface. The used GUVs are synthesized with POPC (16:0-18:1 PC 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine), SM (16:0 Egg Sphingomyelin) and cholesterol at different molecular compositions...
January 11, 2018: Scientific Reports
Kota Kasahara, Masaaki Shiina, Junichi Higo, Kazuhiro Ogata, Haruki Nakamura
Multi-modal interactions are frequently observed in intrinsically disordered regions (IDRs) of proteins upon binding to their partners. In many cases, post-translational modifications in IDRs are accompanied by coupled folding and binding. From both molecular simulations and biochemical experiments with mutational studies, we show that the IDR including a Ser rich region (SRR) of the transcription factor Ets1, just before the DNA-binding core domain, undergoes multi-modal interactions when the SRR is not phosphorylated...
January 4, 2018: Nucleic Acids Research
Hironori Ozaki, Ran Inoue, Takako Matsushima, Masakiyo Sasahara, Atsushi Hayashi, Hisashi Mori
Diabetic retinopathy (DR) is a leading cause of blindness. DR is recognized as a microvascular disease and inner retinal neurodegeneration. In the course of retinal neurodegeneration, N-methyl-D-aspartate receptor (NMDAR)-mediated excitotoxicity is involved. Full activation of NMDAR requires binding of agonist glutamate and coagonist glycine or D-serine. D-Serine is produced from L-serine by serine racemase (SRR) and contributes to retinal neurodegeneration in rodent models of DR. However, the involvement of SRR in both neurodegeneration and microvascular damage in DR remains unclear...
2018: PloS One
Wilson Bautista-Molano, Robert Landewé, Rubén Burgos-Vargas, José Maldonado-Cocco, Anna Moltó, Filip van den Bosch, Rafael Valle-Oñate, Maxime Dougados, Désirée van der Heijde
OBJECTIVE: Increased risk of comorbidities has been reported in spondyloarthritis (SpA). The objective of this study was to determine the prevalence and risk of developing comorbidities in patients with SpA in 3 Latin American (LA) countries, and to compare that prevalence with the general population. METHODS: Data were analyzed from 390 patients with SpA enrolled in the Assessment of SpondyloArthritis international Society of Comorbidities in SpA study from Argentina, Colombia, and Mexico...
December 15, 2017: Journal of Rheumatology
D Bruce Burckel, Bryan M Adomanis, Michael B Sinclair, Salvatore Campione
This paper investigates three-dimensional cut wire pair (CWP) behavior in vertically oriented meta-atoms. We first analyze CWP metamaterial inclusions using full-wave electromagnetic simulations. The scattering behavior of the vertical CWP differs substantially from that of the planar version of the same structure. In particular, we show that the vertical CWP supports a magnetic resonance that is solely excited by the incident magnetic field. This is in stark contrast to the bianisotropic resonant excitation of in-plane CWPs...
December 11, 2017: Optics Express
Roxana Moslehi, Nur Zeinomar, Francis P Boscoe
OBJECTIVES: Ultraviolet radiation (UVR), with UVB and UVA as the relevant components, is a risk factor for melanoma. Complete ascertainment and registration of melanoma in Iran was conducted in five provinces (Ardabil, Golestan, Mazandaran, Gilan and Kerman) during 1996-2000. The aim of our study was to compare population-based incidence data from these provinces with rates in the United States (US) while standardizing ambient UVR. METHODS: Population-based rates representing all incident cases of melanoma (1996-2000) across the five Iranian provinces were compared to rates of melanoma among white non-Hispanics in the US...
December 11, 2017: Environmental Pollution
Guillermo A Naranjo, Xomalin G Peralta
We measured the transmission spectra of an array of split-ring resonators (SRRs) up to 10 terahertz for parallel and perpendicular polarizations. Calculations of the lattice and plasmon mode dispersion relations, in combination with electromagnetic simulations, confirm the presence of multiple higher-order lattice and plasmon modes. We modify the quality factor of higher-order plasmon resonances by modulating the lattice-plasmon mode coupling via changes in the period of the array. We also propose single frequency switches and a broadband dual-state amplitude modulator based on structured illumination that actively modifies the period of the SRR array...
December 1, 2017: Optics Letters
Chieh-Hsin Lin, Eugene Lin, Hsien-Yuan Lane
With ever-increasing elder populations, age-related cognitive decline, which is characterized as a gradual decline in cognitive capacity in the aging process, has turned out to be a mammoth public health concern. Since genetic information has become increasingly important to explore the biological mechanisms of cognitive decline, the search for genetic biomarkers of cognitive aging has received much attention. There is growing evidence that single-nucleotide polymorphisms (SNPs) within the ADAMTS9, BDNF, CASS4, COMT, CR1, DNMT3A, DTNBP1, REST, SRR, TOMM40, circadian clock, and Alzheimer's diseases-associated genes may contribute to susceptibility to cognitive aging...
2017: Frontiers in Psychiatry
Ning Jiang, Feng Huang, Xiurong Zhang
Background: Conflicting evidence exists for observational studies on whether tobacco smoking is a risk factor for diabetic nephropathy (DN) in patients with type 1 (T1DM) and type 2 diabetes mellitus (T2DM). In this meta-analysis, we aimed to assess the effects of tobacco smoking on the development of DN. Materials and Methods: We searched MEDLINE and EMBASE databases from their inception to March 31st, 2017 for cross-sectional, case-control, and prospective cohort studies...
November 3, 2017: Oncotarget
Roberto Tozzi, Jvan Casarin, Riccardo Garruto-Campanile, Hooman Soleymani Majd, Matteo Morotti
OBJECTIVE: To investigate the morbidity of diverting loop ileostomy (DLI) performed during Visceral Peritoneal Debulking (VPD) for stage IIIC-IV ovarian cancer and to report the rate, timing, and morbidity of DLI reversal. METHODS: We retrieved the data of all consecutive patients who underwent sigmoid-rectum resection (SRR) followed by DLI. Morbidity was defined as any surgical/medical complications clearly correlated to the DLI. The reversal rate of DLI was defined as the number of patients who had the continuity of the gastrointestinal tract restored in the study period...
November 20, 2017: Gynecologic Oncology
Donald J Noble, William N Goolsby, Sandra M Garraway, Karmarcha K Martin, Shawn Hochman
In humans, exercises involving slowed respiratory rate (SRR) counter autonomic sympathetic bias and reduce responses to stressors, including in individuals with various degrees of autonomic dysfunction. In the rat, we examined whether operant conditioning could lead to reductions in respiratory rate (RR) and performed preliminary studies to assess whether conditioned SRR was sufficient to decrease physiological and behavioral responsiveness to stressors. RR was continuously monitored during 20 2-h sessions using whole body plethysmography...
2017: Frontiers in Physiology
Xinyue Zhang, Ning Jiang, Lijuan Wang, Huaman Liu, Rong He
Background: Studies exploring the association between chronic obstructive pulmonary disease (COPD) and lung cancer have yielded mixed results. We conducted a meta-analysis of the published prospective cohort studies to have a clear understanding about this association. Methods: We searched the MEDLINE and EMBASE databases from inception to December 31, 2016. Bibliographies were also reviewed for additional information. Random-effects model was used to calculate summary relative risk (SRR) and corresponding 95% confidence interval (CI)...
September 29, 2017: Oncotarget
Shaojing Zhang, Qingwei Wang, Juanjuan He
Background: Findings on the association between intake of red and processed meat with renal cell carcinoma (RCC) risk are mixed. We conducted a meta-analysis to investigate this association. Materials and Methods: Eligible studies up to August 31, 2016, were identified and retrieved by searching the MEDLINE and Embase databases along with manual review of the reference lists from the retrieved studies. The quality of the included studies was evaluated using the Newcastle-Ottawa Quality Assessment Scale...
September 29, 2017: Oncotarget
Andrew E Lincoln, Robert A Vogel, Thomas W Allen, Reginald E Dunn, Kezia Alexander, Nathaniel D Kaufman, Andrew M Tucker
PURPOSE: Previous research identified decreased overall and cardiovascular mortality for National Football League (NFL) players from the 1959-1988 era. The present study explored the mortality risk among recent NFL players who played in an era of heavier linemen and nearly year-round physical conditioning. METHODS: This cohort study included 9778 former NFL players with at least one year in the NFL whose last season was between 1986 and 2012. Players' pension fund records were matched to the National Death Index (NDI) to determine vital status, date of death, and cause of death...
October 26, 2017: Medicine and Science in Sports and Exercise
Chen Chen, Guan Wang, Lilan Peng, Kai Zhang
The development of surface enhanced infrared absorption has been constrained by the limited field enhancement and narrow-band resonance of commonly used metal resonators. In this theoretical work, the design of a crescent resonator (CR) combined with graphene-enabled plasmon tuning is proposed to settle the drawbacks. The CR is similar to a split ring resonator (SRR), but exhibits a much improved field enhancement. The influence of graphene on the field enhancement of the CR has been systematically investigated...
September 18, 2017: Optics Express
Zhenyu Zhao, Xiaobo Zheng, Wei Peng, Jianbing Zhang, Hongwei Zhao, Zhijian Luo, Wangzhou Shi
We experimentally investigate the terahertz (THz) electromagnetically-induced transparency (EIT)-like phenomenon in a metamolecule (MM) of three-body system. This system involves a couple of geometrically identical split-ring resonators (SRRs) in orthogonal layout conductively coupled by a cut-wire resonator. Such a three-body system exhibits two frequency response properties upon to the polarization of incident THz beam: One is the dark-bright-bright layout to the horizontally polarized THz beam, where there is no EIT-like effect; the other is bright-dark-dark layout to the vertically polarized THz beam, where an EIT-like effect is observable...
October 2, 2017: Optics Express
Chenyu Li, Chun-Chieh Chang, Qingli Zhou, Cunlin Zhang, Hou-Tong Chen
We investigate edge-coupling of twisted split-ring resonator (SRR) pairs in the terahertz (THz) frequency range. Using a simple coupled-resonator model we show that such a system exhibits resonance splitting and cross-polarization conversion. Numerical simulations and experimental measurements agree well with theoretical calculations, verifying the resonance splitting as a function of the coupling strength given by the SRR separation. We further show that a metal ground plane can be integrated to significantly enhance the resonance coupling, which enables the effective control of resonance splitting and the efficiency and bandwidth of the cross-polarization conversion...
October 16, 2017: Optics Express
Dalius Seliuta, Gediminas Šlekas, Andrius Vaitkūnas, Žilvinas Kancleris, Gintaras Valušis
It is demonstrated that higher-order plasmonic modes in the split-ring resonators (SRRs) are strongly enhanced when SRRs are arranged in a densely spaced two-dimensional array. The mode enhancement results from the near-field electrical coupling between the adjacent resonators. The effect is most pronounced in narrow gap SRRs which allows to observe experimentally plasmon modes up to the seventh order. In the array of narrow gap SRRs, the fifth-order resonance demonstrates high Q-factor, high resonance strength and wide tunability which opens up attractive features for practical applications of planar SRR structures...
October 16, 2017: Optics Express
Darrick T Balu, Kendall Taylor Presti, Cathy C Y Huang, Kevin Muszynski, Inna Radzishevsky, Herman Wolosker, Guia Guffanti, Kerry J Ressler, Joseph T Coyle
BACKGROUND: The amygdala is a central component of the neural circuitry that underlies fear learning. N-methyl-D-aspartate receptor-dependent plasticity in the amygdala is required for pavlovian fear conditioning and extinction. N-methyl-D-aspartate receptor activation requires the binding of a coagonist, D-serine, which is synthesized from L-serine by the neuronal enzyme serine racemase (SR). However, little is known about SR and D-serine function in the amygdala. METHODS: We used immunohistochemical methods to characterize the cellular localization of SR and D-serine in the mouse and human amygdala...
August 26, 2017: Biological Psychiatry
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