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JOURNAL ARTICLE
Carlos Abril-Pérez, Miguel Mansilla-Polo, Begoña Escutia-Muñoz, Onofre Sanmartín, Joan R Garcés, Manuel A Rodríguez-Prieto, Verónica Ruiz-Salas, Esther de Eusebio-Murillo, Román Miñano-Medrano, Beatriz González-Sixto, Juan L Artola-Igarza, Alberto Alfaro-Rubio, Pedro Redondo, Yolanda Delgado-Jiménez, Julia M Sánchez-Schmidt, Irati Allende-Markixana, María L Alonso-Pacheco, Beatriz García-Bracamonte, Pablo de la Cueva-Dobao, Raquel Navarro-Tejedor, Cristina Ciudad-Blanco, Lucía Carnero-González, Hugo Vázquez-Veiga, Natividad Cano-Martínez, Carlos Serra-Guillén, Eva Vilarrasa, Pedro Sánchez-Sambucety, José L López-Estebaranz, Ángeles Flórez-Menéndez, Antonio Martorell-Calatayud, Pilar Gil, Victoriano Morales-Gordillo, Agustí Toll, Izascun Ocerin-Guerra, Matías Mayor-Arenal, Ricardo Suárez-Fernández, Laura Sainz-Gaspar, Miguel A Descalzo, Ignacio Garcia-Doval, Rafael Botella-Estrada
BACKGROUND: Immunosuppressed (IS) patients, particularly solid organ transplant recipients and those on immunosuppressive therapy, face a higher incidence and recurrence of nonmelanoma skin cancers (NMSC), including basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). Mohs micrographic surgery (MMS) is the preferred treatment for high-risk NMSC due to its high cure rate and margin examination capabilities. However, IS patients may experience more complications, such as surgical site infections, and a greater risk of recurrence, making their outcomes a subject of interest...
May 11, 2024: Journal of the European Academy of Dermatology and Venereology: JEADV
#2
REVIEW
Haiyan Shi, Jun Du, Guifang Jin, Huayu Yang, Haiyun Guo, Guojing Yuan, Zhihui Zhu, Wenzhuo Xu, Sainan Wang, Hao Guo, Kele Jiang, Jiahu Hao, Ying Sun, Puyu Su, Zhihua Zhang
BACKGROUND: Human immunodeficiency virus (HIV) infection has become a major contributor to the global burden of disease. Globally, the number of cases of HIV continues to increase. Electronic health (eHealth) interventions have emerged as promising tools to support disease self-management among people living with HIV. The purpose of this umbrella review is to systematically evaluate and summarize the evidence and results of published systematic reviews and meta-analyses on the effectiveness of eHealth interventions for HIV prevention, testing and management...
May 11, 2024: International Journal of STD & AIDS
#3
JOURNAL ARTICLE
Matthias Augustin, Dominik Beier, Jennifer Branner, Dennis Häckl, Regina Hampel, Thomas Kramps, Hjalmar Kurzen, Hannah Lintener, Nima Melzer, Malina Müller, Petra Staubach, Uwe Schwichtenberg, Christian Termeer, Alexander Zink, Petra Nathan, Marcus Maurer
BACKGROUND AND STUDY AIM: Data from the AWARE study (A Worldwide Antihistamine-Refractory chronic urticaria patient Evaluation) illustrate a substantial disease burden in German patients with H1-antihistamine (-H1-AH)-refractory chronic spontaneous urticaria (CSU). Detrimental effects on patients' quality of life, poor disease control and impairment in the ability to work and perform other daily activities are reported. Based on these findings, this study aims to quantify the epidemiological and socio-economic burden of H1-AH-refractory CSU in Germany...
May 11, 2024: Journal of the European Academy of Dermatology and Venereology: JEADV
#4
JOURNAL ARTICLE
Alon Scope, Konstantinos Liopyris, Jochen Weber, Raymond L Barnhill, Ralph P Braun, Clara N Curiel-Lewandrowski, David E Elder, Gerardo Ferrara, Jane M Grant-Kels, Thiago Jeunon, Aimilios Lallas, Jennifer Y Lin, Michael A Marchetti, Ashfaq A Marghoob, Cristian Navarrete-Dechent, Giovanni Pellacani, Hans Peter Soyer, Alexander Stratigos, Luc Thomas, Harald Kittler, Veronica Rotemberg, Allan C Halpern
BACKGROUND: A common terminology for diagnosis is critically important for clinical communication, education, research and artificial intelligence. Prevailing lexicons are limited in fully representing skin neoplasms. OBJECTIVES: To achieve expert consensus on diagnostic terms for skin neoplasms and their hierarchical mapping. METHODS: Diagnostic terms were extracted from textbooks, publications and extant diagnostic codes. Terms were hierarchically mapped to super-categories (e...
May 11, 2024: Journal of the European Academy of Dermatology and Venereology: JEADV
#5
JOURNAL ARTICLE
Cailin Liu, Jing Yu, Chunguang Chen, Xiaogai Li, Yafei Ye, Yani Dong, Xinxin Ying, Haijun Li, Wanhai Wang
BACKGROUND: Recently, linezolid-resistant staphylococci have become an emerging problem worldwide. Understanding the mechanisms of resistance, molecular epidemiology and transmission of linezolid-resistant CoNS in hospitals is very important. METHODS: The antimicrobial susceptibilities of all isolates were determined by the microdilution method. The resistance mechanisms and molecular characteristics of the strains were determined using whole-genome sequencing and PCR...
May 10, 2024: BMC Infectious Diseases
#6
JOURNAL ARTICLE
Tamizhini Loganathan, John Fletcher, Priya Abraham, Rajesh Kannangai, Chiranjib Chakraborty, Achraf El Allali, Alsamman M Alsamman, Hatem Zayed, George Priya Doss C
BACKGROUND: Monkeypox (Mpox) is an important human pathogen without etiological treatment. A viral-host interactome study may advance our understanding of molecular pathogenesis and lead to the discovery of suitable therapeutic targets. METHODS: GEO Expression datasets characterizing mRNA profile changes in different host responses to poxviruses were analyzed for shared pathway identification, and then, the Protein-protein interaction (PPI) maps were built. The viral gene expression datasets of Monkeypox virus (MPXV) and Vaccinia virus (VACV) were used to identify the significant viral genes and further investigated for their binding to the library of targeting molecules...
May 10, 2024: BMC Infectious Diseases
#7
JOURNAL ARTICLE
Jules Mongane, Erick Hendwa, Dieudonné Sengeyi, Etienne Kajibwami, Freddy Kampara, Serge Chentwali, Claude Kalegamire, Isaac Barhishindi, Yvette Kujirakwinja, Jeanne Beija Maningo, Benjamin Kasago, Guy Mulinganya
BACKGROUND: Tubal factor infertility (TFI) is common in sub-Saharan Africa and often secondary to pelvic inflammatory disease (PID). Anaerobes associated with bacterial vaginosis (BV) are also found in PIDs widely dominated by Chlamydia trachomatis (C. trachomatis), whose role in TFI is better demonstrated than that of BV. OBJECTIVES: To determine the prevalence of BV and C. trachomatis and to investigate the association between BV, C. trachomatis and TFI. METHODS: We included 137 patients treated for infertility between January 2020 and November 2021...
May 10, 2024: BMC Infectious Diseases
#8
JOURNAL ARTICLE
Daniela Neudecker, Nora Fritisch, Thomas Sutter, Lenette Lu, Pei Lu, Marc Tebruegge, Begoña Santiago-Garcia, Nicole Ritz
BACKGROUND: Tuberculosis (TB) poses a major public health challenge, particularly in children. A substantial proportion of children with TB disease remain undetected and unconfirmed. Therefore, there is an urgent need for a highly sensitive point-of-care test. This study aims to assess the performance of serological assays based on various antigen targets and antibody properties in distinguishing children (0-18 years) with TB disease (1) from healthy TB-exposed children, (2) children with non-TB lower respiratory tract infections, and (3) from children with TB infection...
May 10, 2024: BMC Infectious Diseases
#9
JOURNAL ARTICLE
Yuxin Lin, Yifan Chen, Weiyin Lu, Yu Zhang, Rongqian Wu, Zhaoqing Du
BACKGROUND & AIMS: Pyogenic liver abscess (PLA) is a common hepatobiliary infection that has been shown to have an increasing incidence, with biliary surgery being identified as a trigger. Our aim was to investigate the clinical characteristics and treatments of PLA patients with and without a history of biliary surgery (BS). METHODS: The study included a total of 353 patients with PLA who received treatment at our hospital between January 2014 and February 2023...
May 10, 2024: BMC Infectious Diseases
#10
JOURNAL ARTICLE
Lin Wu, Jingshi Wang, Deli Song, Yahong You, Zhao Wang
BACKGROUND: Haemophagocytic lymphohistiocytosis (HLH) is a syndrome that occurs in patients with severe systemic hyperinflammation. GATA binding protein 2 (GATA2) is a transcription factor and key component in haematopoiesis and stem cell biology. CASE PRESENTATION: Three patients with HLH, one with Mycobacterium avium infection, one with Epstein-Barr virus (EBV) infection, and one with Mycobacterium kansasii infection, were all subsequently found to have a defect in the GATA2 gene through genetic testing...
May 10, 2024: BMC Infectious Diseases
#11
JOURNAL ARTICLE
Wei Zhuang, Tao He, Jianyekai Tuerheng, Guang He, Bao-Li Wang, Yi-Heng Yang, Lan Zhang, Xian-Zhe Dong, Sheng-Yan Xi
BACKGROUND: Neurobrucellosis (NB) is a rare and serious complication of brucellosis. Its clinical manifestations vary, with no obvious specificity. At present, there is no clear clinical diagnosis or treatment for reference. In this study, we retrospectively analyzed the clinical data for 21 patients with NB to provide reference data for its further study. METHODS: We analyzed the epidemiological and clinical manifestations, laboratory tests, imaging examinations, cerebrospinal fluid, and treatment plans of 21 patients diagnosed with NB in the Department of Neurology, Xuanwu Hospital, Capital Medical University Beijing, China...
May 10, 2024: BMC Infectious Diseases
#12
JOURNAL ARTICLE
Hanies Yuhana Othman, Izzati Abdul Halim Zaki, Mohamad Rodi Isa, Long Chiau Ming, Hanis Hanum Zulkifly
Thromboembolic (TE) complications [myocardial infarction (MI), stroke, deep vein thrombosis (DVT), and pulmonary embolism (PE)] are common causes of mortality in hospitalised COVID-19 patients. Therefore, this review was undertaken to explore the incidence of TE complications and mortality associated with TE complications in hospitalised COVID-19 patients from different studies. A literature search was performed using ScienceDirect and PubMed databases using the MeSH term search strategy of "COVID-19", "thromboembolic complication", "venous thromboembolism", "arterial thromboembolism", "deep vein thrombosis", "pulmonary embolism", "myocardial infarction", "stroke", and "mortality"...
May 10, 2024: BMC Infectious Diseases
#13
JOURNAL ARTICLE
Amanda Apato, Stephany Nuñez Cruz, Dharati Desai, Giles W Slocum
BACKGROUND: The updated 2021 CDC treatment guidelines recommend a single dose of 500 mg intramuscular ceftriaxone for Neisseria gonorrhea and doxycycline 100 mg by mouth twice daily for 7 days for Chlamydia trachomatis coinfection. However, there is a significant public health concern regarding patient non-adherence to the 7-day course of doxycycline. To date, there are no studies assessing this concern. Therefore, the objective of this study was to evaluate a patient's adherence to doxycycline for chlamydial infections after discharge from the Emergency Department (ED)...
May 5, 2024: American Journal of Emergency Medicine
#14
JOURNAL ARTICLE
Burcu Beyazgul, Fatma Koruk, Ibrahim Koruk
OBJECTIVES: Determination of the attitudes of individuals toward sexually transmitted infections (STIs) can also help identify barriers to health service-seeking behavior. Hence, this study aimed to develop a scale for determining the attitudes of individuals toward sexually transmitted diseases. STUDY DESIGN: This was a methodological study. The Health Belief Model (HBM) framework was used to elucidate the perceptions and interpretations of illnesses among individuals...
April 28, 2024: European Journal of Obstetrics, Gynecology, and Reproductive Biology
#15
JOURNAL ARTICLE
Kyma Schnoor, Esther P W A Talboom-Kamp, Muamer Hajtić, Niels H Chavannes, Anke Versluis
BACKGROUND: Health care lags in digital transformation, despite the potential of technology to improve the well-being of individuals. The COVID-19 pandemic has accelerated the uptake of technology in health care and increased individuals' willingness to perform self-management using technology. A web-based service, Directlab Online, provides consumers with direct digital access to diagnostic test packages, which can digitally support the self-management of health. OBJECTIVE: This study aims to identify the facilitators, barriers, and needs of Directlab Online, a self-management service for web-based access to diagnostic testing...
May 10, 2024: JMIR Human Factors
#16
JOURNAL ARTICLE
Arthur H Owora, Rebecca F Houghton, John L Ferrand, Erik Parker, Pamela Anderson, Karin Coyle, Stephanie Guinosso, Eric R Walsh-Buhi
PURPOSE: To examine the impact of About Us, an innovative healthy relationships intervention that promotes positive adolescent romantic relationships and the use of effective contraceptives, on improving behavior, attitudes, and intentions related to sexual intercourse, relationship communication, and conflict resolution at 3- and 9-month follow-up, compared to services as usual. METHODS: This was a multi-site, two-group, parallel, randomized-controlled trial with an intervention/comparison allocation ratio of 3:2 conducted at seven high schools in California between February 2018 and May 2021...
May 9, 2024: Journal of Adolescent Health
#17
JOURNAL ARTICLE
Paul K Tang, Peter Lepping, Sophie G Lepping, Eric O Noorthoorn, Stephen B Squire, Padma Mohandas, Anthony Bewley
BACKGROUND: Data remain scarce for the first-line antipsychotic choice in treating delusional infestation (DI). OBJECTIVES: We evaluated the treatment responses associated with different antipsychotics in DI patients. METHODS: We undertook a multicentre, retrospective observational study using anonymised electronic patient records from two hospitals in the United Kingdom from 1 January 2011 to 1 January 2023. Eligible participants were adults (≥18 years) diagnosed with DI treated with an antipsychotic, and had both an assigned baseline and follow-up Clinical Global Impression Scale (CGI-S) score...
May 10, 2024: Journal of the European Academy of Dermatology and Venereology: JEADV
#18
JOURNAL ARTICLE
J Perez-Anker, S Soglia, C Lenoir, R Albero, L Alos, A García, B Alejo, E Cinotti, C Orte Cano, C Habougit, Ch Dorado Cortes, L Pellegrino, L Tognetti, P Castillo, P Rubegni, M Suppa, J L Perrot, V Del Marmol, S Puig, J Malvehy
BACKGROUND: Line-field confocal optical coherence tomography (LC-OCT) is an emerging diagnostic tool with imaging depth reaching ~400 μm and a novel three-dimensional (3D) cube providing cellular resolution. As far as we are aware, there are only a limited number of papers that have reported diagnostic criteria for melanocytic lesions using this technique, and none of them have been multicentric. OBJECTIVES: Our aim was to establish the diagnostic criteria for melanocytic lesions using LC-OCT and identify the most significant architectural and cytologic features associated with malignancy...
May 10, 2024: Journal of the European Academy of Dermatology and Venereology: JEADV
#19
JOURNAL ARTICLE
Maha T Alsharif, Elham Alsahafi
(1) Background: Human papillomavirus (HPV) infection is significantly associated with oropharyngeal squamous cell carcinoma (HPV-OPSCC), which is one of the fastest-growing cancer incidences globally. Dental practitioners play a crucial role in the primary and secondary prevention of HPV-OPSCC. There is little known about dental students' awareness regarding HPV-OPSCC and HPV vaccination, as well as their intention to promote 'primordial prevention' among their patients. HPV vaccine, and the extent of their professional responsibilities...
April 26, 2024: Healthcare (Basel, Switzerland)
#20
JOURNAL ARTICLE
Olivia Peuchant, Cécile Laurier-Nadalié, Laura Albucher, Carla Balcon, Amandine Dolzy, Nadège Hénin, Arabella Touati, Cécile Bébéar
BackgroundIn France, lymphogranuloma venereum (LGV) testing switched from universal to selective testing in 2016.AimTo investigate changes in LGV-affected populations, we performed a nationwide survey based on temporarily reinstated universal LGV testing from 2020 to 2022.MethodsEach year, during three consecutive months, laboratories voluntarily sent anorectal Chlamydia trachomatis -positive samples from men and women to the National Reference Centre for bacterial sexually transmitted infections. We collected patients' demographic, clinical and biological data...
May 2024: Euro Surveillance
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