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https://www.readbyqxmd.com/read/29444341/high-fat-diet-induced-obesity-promotes-expansion-of-bone-marrow-adipose-tissue-and-impairs-skeletal-stem-cell-functions-in-mice
#1
Michaela Tencerova, Florence Figeac, Nicholas Ditzel, Hanna Taipaleenmäki, Tina Kamilla Nielsen, Moustapha Kassem
Obesity represents a risk factor for development of insulin resistance and Type 2 Diabetes. In addition, it has been associated with increased adipocyte formation in the bone marrow (BM) along with increased risk for bone fragility fractures. However, little is known on the cellular mechanisms that link obesity, BM adiposity and bone fragility. Thus, in an obesity intervention study in C57BL/6J mice fed with high fat diet (HFD) for 12 weeks, we investigated the molecular and cellular phenotype of bone marrow adipose tissue (BMAT), BM progenitor cells and BM microenvironment in comparison to peripheral adipose tissue (AT)...
February 14, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29425272/endometriosis-alters-brain-electro-physiology-gene-expression-and-increased-pain-sensitization-anxiety-and-depression-in-female-mice
#2
Tian Li, Ramanaiah Mamillapalli, Sheng Ding, Hao Chang, Zhong-Wu Liu, Xiao-Bing Gao, Hugh S Taylor
Endometriosis is an estrogen-dependent inflammatory disorder among reproductive-aged women associated with pelvic pain, anxiety, and depression. Pain is characterized by central sensitization, however it is not clear if endometriosis leads to increased pain perception or if women with the disease are more sensitive to pain, increasing the detection of endometriosis. Endometriosis was induced in mice and changes in behavior including pain perception, brain electrophysiology, and gene expression were characterized...
February 7, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29423384/perspectives-in-lipocalin-2-emerging-biomarker-for-medical-diagnosis-and-prognosis-for-alzheimer-s-disease
#3
REVIEW
Juhyun Song, Oh Yoen Kim
Lipocalin-2 (LCN2), a secreted glycoprotein belonging to the lipocalin superfamily was reported to participate in various biological processes including cell migration, cell survival, inflammatory responses, and insulin sensitivity. LCN2 is expressed in the multiple tissues such as kidney, liver, uterus, and bone marrow. The receptors for LCN2 were additionally found in microglia, astrocytes, epithelial cells, and neurons, but the role of LCN2 in the central nervous system (CNS) has not been fully understood yet...
January 2018: Clinical Nutrition Research
https://www.readbyqxmd.com/read/29395573/increased-levels-of-lipocalin-2-in-palmoplantar-pustular-psoriasis
#4
Kerstin Wolk, Yvonne Frambach, Arnd Jacobi, Dagmar Wilsmann-Theis, Sandra Phillipp, Ellen Witte-Händel, Jörg Wenzel, Rotraut Mössner, Robert Sabat
BACKGROUND: Palmoplantar pustular psoriasis (PPP) is a recalcitrant chronic skin disease affecting the palms and soles. OBJECTIVE: To identify and characterize pathogenetic players in PPP. METHODS: Clinical and anamnestic data as well as skin and blood samples of 60 PPP patients were collected. Healthy participants served as controls. Analysis of patient samples and cultured primary skin cells was performed by ELISA, qRT-PCR, and immunohistochemistry...
January 11, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29378951/holo-lipocalin-2-derived-siderophores-increase-mitochondrial-ros-and-impair-oxidative-phosphorylation-in-rat-cardiomyocytes
#5
Erfei Song, Sofhia V Ramos, Xiaojing Huang, Ying Liu, Amy Botta, Hye Kyoung Sung, Patrick C Turnbull, Michael B Wheeler, Thorsten Berger, Derek J Wilson, Christopher G R Perry, Tak W Mak, Gary Sweeney
Lipocalin-2 (Lcn2), a critical component of the innate immune response which binds siderophores and limits bacterial iron acquisition, can elicit spillover adverse proinflammatory effects. Here we show that holo-Lcn2 (Lcn2-siderophore-iron, 1:3:1) increases mitochondrial reactive oxygen species (ROS) generation and attenuates mitochondrial oxidative phosphorylation in adult rat primary cardiomyocytes in a manner blocked by N-acetyl-cysteine or the mitochondria-specific antioxidant SkQ1. We further demonstrate using siderophores 2,3-DHBA (2,3-dihydroxybenzoic acid) and 2,5-DHBA that increased ROS and reduction in oxidative phosphorylation are direct effects of the siderophore component of holo-Lcn2 and not due to apo-Lcn2 alone...
January 29, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29350016/biomarkers-of-treatment-efficacy-in-patients-with-chronic-spontaneous-urticaria
#6
M Sánchez-Borges, A Capriles-Hulett, F Caballero-Fonseca, L González-Aveledo
Background. Currently there are no biomarkers useful to predict the future evolution and the therapeutic response in patients with chronic spontaneous urticaria (CSU). Objective. To review the available information on biomarkers that might be applied for the follow up of the response to guideline recommended therapies for CSU. Methods. A review of the medical literature on CSU potential clinical and laboratory biomarkers in PubMed and MEDLINE including the terms urticaria, chronic urticaria, chronic idiopathic urticaria, chronic spontaneous urticaria, antihistamines (AHs), omalizumab (OMA), cyclosporine (CyA), and treatment...
January 2018: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29346801/early-gene-expression-profile-in-retinal-ganglion-cell-layer-after-optic-nerve-crush-in-mice
#7
Satoru Ueno, Azusa Yoneshige, Yoshiki Koriyama, Man Hagiyama, Yoshikazu Shimomura, Akihiko Ito
Purpose: Optic nerve crush (ONC) induces retinal ganglion cell (RGC) death, which causes vision loss in glaucoma. To investigate early events leading to apoptosis of RGCs, we performed gene expression analysis of injured retinas in the period before RGC loss. Methods: The temporal changes of gene profiles at 0, 1, and 4 days after ONC were determined by DNA microarray. To verify the gene expression changes in RGCs, we enriched RGCs by laser-captured microdissection and performed real-time RT-PCR of 14 selected genes...
January 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29325893/stilamin-inhibits-intestinal-and-pancreatic-injury-in-rats-with-severe-acute-pancreatitis-by-down-regulating-lcn2-expression
#8
Yifan Ren, Qing Cui, Jianbin Bi, Zhaoqing Du, Jia Zhang, Xufeng Zhang, Yi Lv, Rongqian Wu
OBJECTIVE: This study was aimed at exploring the function and mechanism of Stilamin on severe acute pancreatitis (SAP) in rats. METHODS: We analyzed the histology of small intestine and pancreatic tissues of SAP rats and SAP rats plus treatment with Stilamin. The expression levels of IL-6 and TNF-α in serum were detected using ELISA. The expressions of Caspase-3, bcl-2, Bax and p53 in rat tissues of SAP group were verified by qRT-PCR and western blot. The differential expressed mRNAs in rats of SAP group were screened out by microarray analysis...
January 2, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29321030/crabp1-c1ql1-and-lcn2-are-biomarkers-of-differentiated-thyroid-carcinoma-and-predict-extrathyroidal-extension
#9
Ricardo Celestino, Torfinn Nome, Ana Pestana, Andreas M Hoff, A Pedro Gonçalves, Luísa Pereira, Bruno Cavadas, Catarina Eloy, Trine Bjøro, Manuel Sobrinho-Simões, Rolf I Skotheim, Paula Soares
BACKGROUND: The prognostic variability of thyroid carcinomas has led to the search for accurate biomarkers at the molecular level. Follicular thyroid carcinoma (FTC) is a typical example of differentiated thyroid carcinomas (DTC) in which challenges are faced in the differential diagnosis. METHODS: We used high-throughput paired-end RNA sequencing technology to study four cases of FTC with different degree of capsular invasion: two minimally invasive (mFTC) and two widely invasive FTC (wFTC)...
January 10, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29311111/dual-blockade-of-interleukin-1%C3%AE-and-interleukin-17a-reduces-murine-arthritis-pathogenesis-but-also-leads-to-spontaneous-skin-infections-in-non-human-primates
#10
Melanie C Ruzek, Lili Huang, Ting Ting Zhang, Shaughn Bryant, Peter F Slivka, Carolyn A Cuff, Catherine Tripp, Guenter Blaich
Despite the efficacy of biologics for treatment of rheumatoid arthritis (RA), many patients show inadequate responses and likely require neutralization of multiple mediators. Neutralization of both interleukin (IL)-1β and IL-17A with monoclonal antibodies showed greater efficacy than either agent alone in a mouse arthritis model with cooperative inhibition of key inflammatory factors, IL-6, granulocyte colony stimulating factor (G-CSF) and CXC chemokine ligand (CXCL)1. Given the potential clinical benefit in RA, we generated a human dual variable domain antibody (DVD-Ig), ABBV-615, capable of simultaneous binding and neutralization of IL-1β and IL-17A...
January 8, 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29285270/metformin-alleviates-nickel-induced-autophagy-and-apoptosis-via-inhibition-of-hexokinase-2-activating-lipocalin-2-in-human-bronchial-epithelial-cells
#11
Yu-Ting Kang, Wen-Cheng Hsu, Chih-Hsien Wu, I-Lun Hsin, Pei-Ru Wu, Kun-Tu Yeh, Jiunn-Liang Ko
Autophagy is an intracellular recycling and degradation process for regulating tumor progression, survival and drug resistance. Nickel compounds have been identified as human carcinogens. However, the role of nickel-induced autophagy in lung carcinogenesis has not yet been fully elucidated. In this study, we determined that hexokinase 2 (HK2), which phosphorylates glucose and regulates autophagy, is the key mediator in nickel-induced autophagy in lung bronchial epithelial cells. We attempted to investigate the effects of the antidiabetic drug metformin on HK2 expression and lung cancer chemoprevention...
December 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/29234288/lipocalin-2-in-fructose-induced-fatty-liver-disease
#12
Jessica Lambertz, Thorsten Berger, Tak W Mak, Josef van Helden, Ralf Weiskirchen
The intake of excess dietary fructose most often leads to non-alcoholic fatty liver disease (NAFLD). Fructose is metabolized mainly in the liver and its chronic consumption results in lipogenic gene expression in this organ. However, precisely how fructose is involved in NAFLD progression is still not fully understood, limiting therapy. Lipocalin-2 (LCN2) is a small secreted transport protein that binds to fatty acids, phospholipids, steroids, retinol, and pheromones. LCN2 regulates lipid and energy metabolism in obesity and is upregulated in response to insulin...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29204091/lipocalin-2-as-a-clinical-significance-in-rheumatoid-arthritis
#13
Arif Gulkesen, Gurkan Akgol, Ahmet K Poyraz, Suleyman Aydin, Affan Denk, Tulay Yildirim, Arzu Kaya
Aim of the study: In this study, serum lipokalin 2 (LCN-2) levels and its clinical and radiological significance in patients with rheumatoid arthritis was evaluated. Material and methods: The study enrolled 37 patients with RA and 34 healthy controls. Serum LCN-2 level was measured using ELISA method. Patients with DAS 28 scores ≤ 3.2, and > 3.2 were allocated into lower and high/moderate disease activity groups, respectively. Additionally patients were divided into 2 groups as early RA (disease duration ≤ 2 years) and established RA (duration of the disease ≥ 2 years)...
2017: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/29168343/lipocalin-2-lcn2-interferes-with-iron-uptake-by-brucella-abortus-and-dampens-immunoregulation-during-infection-of-raw-264-7-macrophages
#14
Huynh Tan Hop, Lauren Togonon Arayan, Tran Xuan Ngoc Huy, Alisha Wehdnesday Bernardo Reyes, Eun Jin Baek, WonGi Min, Hu Jang Lee, Man Hee Rhee, Kenta Watanabe, Hong Hee Chang, Suk Kim
Lipocalin 2 (Lcn2) is an important innate immunity component against bacterial pathogens. In this study, we report that Lcn2 is induced by Brucella (B.) abortus infection and significantly contributes to the restriction of intracellular survival of Brucella in macrophages. We found that Lcn2 prevented iron uptake by B. abortus through two distinct mechanisms. First, Lcn2 is secreted to capture bacterial siderophore(s) and abrogate iron import by Brucella. Second, Lcn2 decreases the intracellular iron levels during Brucella infection, which probably deprives the invading Brucella of the iron source needed for growth...
November 22, 2017: Cellular Microbiology
https://www.readbyqxmd.com/read/29154799/integrative-omics-data-analyses-of-repeated-dose-toxicity-of-valproic-acid-in-vitro-reveal-new-mechanisms-of-steatosis-induction
#15
Simone G J van Breda, Sandra M H Claessen, Marcel van Herwijnen, Daniël H J Theunissen, Danyel G J Jennen, Theo M C M de Kok, Jos C S Kleinjans
Valproic acid (VPA) is a very potent anti-cancer and neuro-protective drug probably by its HDAC inhibiting properties, which may cause steatosis in the liver. The present study investigates the effect of repetitive VPA treatment of primary human hepatocytes (PHH) on whole genome gene expression-, DNA methylation-, and miRNA changes, using microarrays and integrated data analyses. PHH were exposed to a non-cytotoxic dose of VPA for 5days daily which induced lipid accumulation. Part of the PHH was left untreated for 3days for studying the persistence of 'omics' changes...
November 14, 2017: Toxicology
https://www.readbyqxmd.com/read/29138470/obesity-promoting-and-anti-thermogenic-effects-of-neutrophil-gelatinase-associated-lipocalin-in-mice
#16
Akira Ishii, Goro Katsuura, Hirotaka Imamaki, Hiroyuki Kimura, Keita P Mori, Takashige Kuwabara, Masato Kasahara, Hideki Yokoi, Kousaku Ohinata, Tomoko Kawanishi, Junichi Tsuchida, Yuji Nakamoto, Kazuwa Nakao, Motoko Yanagita, Masashi Mukoyama, Kiyoshi Mori
Neutrophil gelatinase-associated lipocalin (NGAL, lipocalin 2 or LCN2) is an iron carrier protein whose circulating level is increased by kidney injury, bacterial infection and obesity, but its metabolic consequence remains elusive. To study physiological role of LCN2 in energy homeostasis, we challenged female Lcn2 knockout (KO) and wild-type (WT) mice with high fat diet (HFD) or cold exposure. Under normal diet, physical constitutions of Lcn2 KO and WT mice were indistinguishable. During HFD treatment, Lcn2 KO mice exhibited larger brown adipose tissues (BAT), consumed more oxygen, ate more food and gained less body weights as compared to WT mice...
November 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29122651/downregulation-of-lipocalin-2-and-bim-expression-after-remote-limb-preconditioning-in-the-ischemic-rat-brain
#17
Mingli Liu, Jing Chen, Shufan Zhang, Chuancheng Ren
Although it has been proved that remote limb preconditioning (RPC) can exert neurological protection effects after ischemic cerebral stroke (ICS), the underlying mechanisms of RPC still need to be elucidated for its better transformation to clinical application. Lipocalin-2 (LCN2) was upregulated after cerebral ischemia and mediated reperfusion injury in the models of ischemic stroke. So here, we investigated that whether RPC could downregulate the levels of LCN2 protein and its receptor resulting from cerebral ischemia reperfusion (I/R) injury...
November 6, 2017: Brain Research
https://www.readbyqxmd.com/read/29108879/remyelination-modulators-in-multiple-sclerosis-patients
#18
Rabeah Al-Temaimi, Jehad AbuBaker, Irina Al-Khairi, Raed Alroughani
Multiple Sclerosis (MS) is a complex autoimmune neuro-inflammatory disorder characterized by persistent MS plaques in the central nervous system. Resolution of MS plaques is dependent on the remyelination competence of surviving oligodendrocytes and surrounding environment. Here, we assessed myelination modulators in a 100 MS patients against 77 healthy controls. Plasma fractions were used for the assessment of insulin growth factor binding protein1 (IGFBP1), brain-derived neurotrophic factor (BDNF), and lipocalin2 (LCN2) using a Luminex multiplex assay, whereas neurofilament light chain (NF-L) was assessed with an enzyme-linked immunosorbent assay...
December 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/29098164/cell-signaling-pathway-in-12-o-tetradecanoylphorbol-13-acetate-induced-lcn2-gene-transcription-in-esophageal-squamous-cell-carcinoma
#19
Lingying Meng, Muting Wang, Zepeng Du, Zhongmin Fang, Bingli Wu, Jianyi Wu, Wenming Xie, Jian Shen, Tianxiang Zhu, XieE Xu, Liandi Liao, Liyan Xu, Enmin Li, Bin Lan
LCN2 is involved in various cellular functions, including transport of small hydrophobic molecules, protection of MMP9 from proteolytic degradation, and regulating innate immunity. LCN2 is elevated in multiple human cancers, frequently being associated with tumor size, stage, and invasiveness. Our previous studies have shown that LCN2 expression could be induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in esophageal squamous cell carcinoma (ESCC) by the binding of five nucleoproteins (MISP, KLF10, KLF15, PPP1R18, and RXRβ) at a novel TPA-responsive element (TRE), at -152~-60 bp of the 5' flanking region of the LCN2 promoter...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29078046/dendritic-polyglycerol-sulfates-in-the-prevention-of-synaptic-loss-and-mechanism-of-action-on-glia
#20
Dusica Maysinger, Jeff Ji, Alexandre Moquin, Shireen Hossain, Mark A Hancock, Issan Zhang, Philip K Y Chang, Matthew Rigby, Madeleine Anthonisen, Peter Grutter, John C S Breitner, R Anne McKinney, Sabine Reimann, Rainer Haag, Gerhard Multhaup
Dendritic polyglycerols (dPG), particularly dendritic polyglycerol sulfates (dPGS), have been intensively studied due to their intrinsic anti-inflammatory activity. As related to brain pathologies involving neuroinflammation, the current study examined if dPG and dPGS can (i) regulate neuroglial activation, and (ii) normalize the morphology and function of excitatory postsynaptic dendritic spines adversely affected by the neurotoxic 42 amino acid amyloid-β (Aβ42) peptide of Alzheimer disease (AD). The exact role of neuroglia, such as microglia and astrocytes, remains controversial especially their positive and negative impact on inflammatory processes in AD...
October 27, 2017: ACS Chemical Neuroscience
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