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https://www.readbyqxmd.com/read/28104402/racial-and-ethnic-differences-in-the-polycystic-ovary-syndrome-pcos-metabolic-phenotype
#1
Lawrence Engmann, Susan Jin, Fangbai Sun, Richard S Legro, Alex J Polotsky, Karl R Hansen, Christos Coutifaris, Michael P Diamond, Esther Eisenberg, Heping Zhang, Nanette Santoro
BACKGROUND: Women with polycystic ovarian syndrome have a high prevalence of metabolic syndrome and type 2 diabetes mellitus. Blacks and Hispanics have a high morbidity and mortality due to cardiovascular disease and diabetes mellitus in the general population. Since metabolic syndrome is a risk factor for development of type 2 diabetes and cardiovascular disease, understanding any racial and ethnic differences in metabolic syndrome amongst women with polycystic ovarian syndrome is important for prevention strategies...
January 16, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28094826/response-to-dittrich-et-al-non-embryo-destructive-extraction-of-pluripotent-embryonic-stem-cells-overlooked-legal-prohibitions-professional-legal-consequences-and-inconsistencies-in-patent-law
#2
REVIEW
T Faltus, U Storz
The publication of "Non-embryo-destructive Extraction of Pluripotent Embryonic Stem Cells: Implications for Regenerative Medicine and Reproductive Medicine" by Dittrich et al. in Geburtshilfe und Frauenheilkunde 2015; 75: 1239-1242 1 describes various possibilities which could result from the non-embryo-destructive extraction of embryonic stem cells from human blastocysts. But implementing this method is more problematic, both legally and ethically, than the authors have represented it to be and is illegal in Germany...
December 2016: Geburtshilfe und Frauenheilkunde
https://www.readbyqxmd.com/read/28092845/cinnamaldehyde-potentially-attenuates-gestational-hyperglycemia-in-rats-through-modulation-of-ppar%C3%AE-proinflammatory-cytokines-and-oxidative-stress
#3
Ahmed A Hosni, A Adel Abdel-Moneim, Eman S Abdel-Reheim, Samah M Mohamed, Hamdi Helmy
Cinnamon has a history of use for medicinal purposes and its major benefits have been linked to cinnamaldehyde. The present study aimed to investigate the hypoglycemic action of cinnamaldehyde against fatty-sucrosed diet/streptozotocin (FSD/STZ)-rat model of gestational diabetes. Female albino rats were divided into three groups. Group I fed with normal diet (ND) while group II and III were fed with FSD for eight weeks (five weeks pre-gestational and three weeks gestational). Rats of group III were administered with a daily oral dose of 20mg/kg cinnamaldehyde one week before mating onward...
January 13, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28092229/decamethylcyclopentasiloxane-d5
#4
(no author information available yet)
Decamethylcyclopentasiloxane (D5; CAS No. 541-02-6) is a precursor in the production of siloxane polymers for industry and medicine and is a carrier ingredient in many toiletries and cosmetics. D5 has a relatively low order of toxicity following acute administration via the oral, dermal, and inhalation routes of exposure. It is not considered to be a dermal or eye irritant or a dermal sensitizer. There is no appreciable dermal absorption of D5 based on results from in vivo and in vitro studies. It has not been shown to be genotoxic/mutagenic when tested in a number of short-term in vitro and in vivo assays and did not cause reproductive or developmental toxicity in rats...
January 2017: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/28089575/association-of-uterine-fibroids-and-pregnancy-outcomes-after-ovarian-stimulation-intrauterine-insemination-for-unexplained-infertility
#5
Aaron K Styer, Susan Jin, Dan Liu, Baisong Wang, Alex J Polotsky, Mindy S Christianson, Wendy Vitek, Lawrence Engmann, Karl Hansen, Robert Wild, Richard S Legro, Christos Coutifaris, Ruben Alvero, Randal D Robinson, Peter Casson, Gregory M Christman, Alicia Christy, Michael P Diamond, Esther Eisenberg, Heping Zhang, Nanette Santoro
OBJECTIVE: To investigate the association of non-cavity-distorting uterine fibroids and pregnancy outcomes after ovarian stimulation-intrauterine insemination (OS-IUI) in couples with unexplained infertility. DESIGN: Secondary analysis from a prospective, randomized, multicenter clinical trial investigating fertility outcomes after OS-IUI. SETTING: Reproductive Medicine Network clinical sites. PATIENT(S): Nine hundred couples with unexplained infertility who participated in the Assessment of Multiple Intrauterine Gestations from Ovarian Stimulation (AMIGOS) clinical trial...
January 12, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28088261/parquetina-nigrescens-leaves-chemical-profile-and-influence-on-the-physical-and-biochemical-indices-of-sexual-activity-of-male-wistar-rats
#6
Omowumi Titilola Kayode, Musa Toyin Yakubu
OBJECTIVE: The leaves of Parquetina nigrescens have been claimed in folk medicine to be useful for managing sexual dysfunction, but there is inadequate scientific evidence for this claim. This investigation was conducted to assess the effects of aqueous leaf extract of Parquetina nigrescens (AEPN) in rats induced with sexual dysfunction. METHODS: Male rats were allocated into various groups after being induced into sexual dysfunction with paroxetine hydrochloride...
January 2017: Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28079902/phenx-measures-for-phenotyping-rare-genetic-conditions
#7
Michael Phillips, Tracey Grant, Philip Giampietro, Joann Bodurtha, Rodolfo Valdez, Deborah R Maiese, Tabitha Hendershot, Sharon F Terry, Carol M Hamilton
INTRODUCTION: The PhenX Toolkit, an online resource of well-established measures of phenotypes and exposures, now has 16 new measures recommended for assessing rare genetic conditions. MATERIALS AND METHODS: These measures and their protocols were selected by a working group of domain experts with input from the scientific community. RESULTS: The measures, which cover life stages from birth through adulthood, include clinical scales, characterization of rare genetic conditions, bioassays, and questionnaires...
January 12, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/28079780/subspecialty-influence-on-scientific-peer-review-for-an-obstetrics-and-gynecology-journal-with-a-high-impact-factor
#8
Laura I Parikh, Rebecca S Benner, Thomas W Riggs, Nicholas Hazen, Nancy C Chescheir
OBJECTIVE: To evaluate whether quality of peer review and reviewer recommendation differ based on reviewer subspecialty in obstetrics and gynecology and to determine the role of experience on reviewer recommendation. METHODS: We performed a retrospective cohort study of reviews submitted to Obstetrics & Gynecology between January 2010 and December 2014. Subspecialties were determined based on classification terms selected by each reviewer and included all major obstetrics and gynecology subspecialties, general obstetrics and gynecology, and nonobstetrics and gynecology categories...
January 9, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28077678/disruptive-reproductive-technologies
#9
REVIEW
I Glenn Cohen, George Q Daley, Eli Y Adashi
In vitro gametogenesis raises new possibilities for reproductive and regenerative medicine as well as vexing policy challenges.
January 11, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28069181/recommendations-for-practices-utilizing-gestational-carriers-a-committee-opinion
#10
(no author information available yet)
This document provides the latest recommendations for evaluation of gestational carriers and intended parents. It incorporates recent information from the US Centers for Disease Control and Prevention, the US Food and Drug Administration, and the American Association of Tissue Banks, with which all programs offering gestational carrier services must be thoroughly familiar. This document replaces the previous document of the same name, last published in 2015 (Fertil Steril 2015; 103:e1-8).
January 6, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28068904/long-term-kinetics-of-zika-virus-rna-and-antibodies-in-body-fluids-of-a-vasectomized-traveller-returning-from-martinique-a-case-report
#11
Guenter Froeschl, Kristina Huber, Frank von Sonnenburg, Hans-Dieter Nothdurft, Gisela Bretzel, Michael Hoelscher, Lothar Zoeller, Matthias Trottmann, Francisco Pan-Montojo, Gerhard Dobler, Silke Woelfel
BACKGROUND: The magnitude of the current Zika virus (ZIKV) epidemic has led to a declaration of a Public Health Emergency of International Concern by the WHO. Findings of viable viral particles in semen for several weeks are corroborating reports of sexual transmission of ZIKV. Serious consequences of a positive diagnostic result particularly in the pregnant patient are calling for precise diagnostic tools also at later time points after infection. Currently, recommendations suggest a diagnostic period of direct viral detection of 5 to 7 days after onset of symptoms in serum or plasma, and up to 3 weeks in urine samples...
January 10, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28052344/understanding-the-molecular-mechanisms-of-the-interplay-between-herbal-medicines-and-gut-microbiota
#12
REVIEW
Jun Xu, Hu-Biao Chen, Song-Lin Li
Herbal medicines (HMs) are much appreciated for their significant contribution to human survival and reproduction by remedial and prophylactic management of diseases. Defining the scientific basis of HMs will substantiate their value and promote their modernization. Ever-increasing evidence suggests that gut microbiota plays a crucial role in HM therapy by complicated interplay with HM components. This interplay includes such activities as: gut microbiota biotransforming HM chemicals into metabolites that harbor different bioavailability and bioactivity/toxicity from their precursors; HM chemicals improving the composition of gut microbiota, consequently ameliorating its dysfunction as well as associated pathological conditions; and gut microbiota mediating the interactions (synergistic and antagonistic) between the multiple chemicals in HMs...
January 4, 2017: Medicinal Research Reviews
https://www.readbyqxmd.com/read/28050670/personalizing-reproductive-medicine-a-biological-or-technocratic-imperative
#13
EDITORIAL
David F Albertini
No abstract text is available yet for this article.
January 3, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28049346/genoproteomics-assisted-improvement-of-andrographis-paniculata-toward-a-promising-molecular-and-conventional-breeding-platform-for-autogamous-plants-affecting-the-pharmaceutical-industry
#14
Alireza Valdiani, Daryush Talei, Surrinder K Lattoo, Rodomiro Ortiz, Søren Kjærsgaard Rasmussen, Jacqueline Batley, Mohd Yusop Rafii, Mahmood Maziah, Kallevettankuzhy K Sabu, Rambod Abiri, Suchirat Sakuanrungsirikul, Soon Guan Tan
Andrographis paniculata (Burm. f.) Wall. ex Nees. (AP) is a hermaphroditic, self-compatible, and habitual inbreeding plant. Its main bioactive component is andrographolide, which is capable of inducing autophagic cell death in some human cancer cells and helps fight HIV/AIDS. Increasing the andrographolide content by investigating the genetic mechanisms controlling its biosynthesis in order to improve and develop high-yielding cultivars are the main breeding targets for AP. However, there might exist some limitations or barriers for crossability within AP accessions...
January 3, 2017: Critical Reviews in Biotechnology
https://www.readbyqxmd.com/read/28046159/technical-note-a-new-surgical-technique-for-ovariohysterectomy-during-early-pregnancy-in-beef-heifers
#15
K J McLean, C R Dahlen, P P Borowicz, L P Reynolds, M R Crosswhite, B W Neville, S D Walden, J S Caton
We hypothesized that a standing flank ovariohysterectomy procedure could be developed in beef heifers that would provide high quality tissues for addressing critical questions during early pregnancy, while concomitantly keeping livestock stewardship a high priority. To test the hypothesis, we: 1) developed a standing flank ovariohysterectomy procedure for use in beef heifers, and 2) implemented this procedure in a cohort of heifers up to d 50 of pregnancy for tissue collections, documentation of post-surgical recovery, and assessment of feedlot finishing performance...
December 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/28035407/the-development-and-biological-characteristics-of-a-novel-potentially-radioresistant-inbred-mouse-strain
#16
Qin Wang, Liqing Du, Yan Wang, Chang Xu, Zhijuan Sun, Yue Fu, Bing Yang, Yueying Wang, Chuanjie Mu, Saijun Fan, Lu Cai, Takanori Katsube, Qiang Liu
The growth of biomedical research over the previous decades has been accompanied by an increase in the number, complexity and diversity of experimental animals developed as research tools, and inbred mice are some of the most widely used. However, thus far, no inbred mice have exhibited strong radioresistance for use in radiation‑damage research. To develop a radioresistant mouse model, a female Japanese outbreeding strain ICR/JCL mouse was mated with a male Chinese inbred strain 615 mouse. From the F1 generation, the mouse line was maintained by brother‑to‑sister mating...
February 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28035266/simple-and-noninvasive-method-for-assessment-of-digestive-efficiency-validation-of-fecal-steatocrit-in-greenfinch-coccidiosis-model
#17
Richard Meitern, Mari-Ann Lind, Ulvi Karu, Peeter Hõrak
Animals' capability to absorb energy and nutrients from food poses a major internal constraint that affects the amount of resources available for allocation to maintenance, growth, signaling, and reproduction. Intestinal surface is the largest area of contact between immune system and microbial antigens; gut thus appears the main arena where trade-offs between immune function and other components of fitness arise. Assessment of the integrity of digestive machinery should therefore be of high priority in ecophysiological research...
December 2016: Ecology and Evolution
https://www.readbyqxmd.com/read/28034651/patient-surgeon-and-hospital-disparities-associated-with-benign-hysterectomy-approach-and-perioperative-complications
#18
Ambar Mehta, Tim Xu, Susan Hutfless, Martin A Makary, Abdulrahman K Sinno, Edward J Tanner, Rebecca L Stone, Karen Wang, Amanda N Fader
BACKGROUND: Hysterectomy is among the most common major surgical procedures performed in women. Approximately 450,000 hysterectomy procedures are performed each year in the United States for benign indications. However, little is known regarding contemporary U.S. hysterectomy trends for women with benign disease with respect to operative technique and perioperative complications, and the association between these two factors with patient, surgeon, and hospital characteristics. OBJECTIVES: To describe contemporary hysterectomy trends and explore associations between patient, surgeon, and hospital characteristics with surgical approach and perioperative complications...
December 26, 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28033658/multiple-exposures-to-environmental-pollutants-and-oxidative-stress-is-there-a-sex-specific-risk-of-developmental-complications-for-fetuses
#19
REVIEW
Kaïs H Al-Gubory
Medically assisted procreation significantly contributes to an increase in twin pregnancies. One of the major factors contributing to more twin births is the use of fertility treatments. Twin pregnancy is not without a risk for fetal organ development and the health outcome of new-borns, children, and adults. Multiple pregnancies are associated with an increased risk of developmental complications, such as perinatal mortality, premature births, and low birth weight. Oxidative stress is involved in pregnancy disorders such as abortion, intrauterine growth retardation, and prenatal mortality...
December 2016: Birth Defects Research. Part C, Embryo Today: Reviews
https://www.readbyqxmd.com/read/28031375/urinary-phytoestrogen-concentrations-are-not-associated-with-incident-endometriosis-in-premenopausal-women
#20
Sunni L Mumford, Jennifer Weck, Kurunthachalam Kannan, Germaine M Buck Louis
BACKGROUND: Phytoestrogens have been associated with subtle hormonal changes, but their effects on endometriosis are largely unknown. OBJECTIVE: We assessed the association between urinary concentrations of phytoestrogens and incident endometriosis. METHODS: We included an operative sample of 495 premenopausal women aged 18-44 y undergoing laparoscopies and laparotomies at 14 clinical sites between 2007 and 2009 and a general population sample of 131 women from the same geographic area who were matched on age and menstruation status...
December 28, 2016: Journal of Nutrition
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