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hydroxycitric acid

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https://www.readbyqxmd.com/read/27904492/hydroxycitric-acid-ameliorates-inflammation-and-oxidative-stress-in-mouse-models-of-multiple-sclerosis
#1
Mahdi Goudarzvand, Sanaz Afraei, Somaye Yaslianifard, Saleh Ghiasy, Ghazal Sadri, Mustafa Kalvandi, Tina Alinia, Ali Mohebbi, Reza Yazdani, Shahin Khadem Azarian, Abbas Mirshafiey, Gholamreza Azizi
Hydroxycitric acid (HCA) is derived primarily from the Garcinia plant and is widely used for its anti-inflammatory effects. Multiple sclerosis can cause an inflammatory demyelination and axonal damage. In this study, to validate the hypothesis that HCA exhibits therapeutic effects on multiple sclerosis, we established female C57BL/6 mouse models of multiple sclerosis, i.e., experimental autoimmune encephalomyelitis, using Complete Freund's Adjuvant (CFA) emulsion containing myelin oligodendrocyte glycoprotein (35-55)...
October 2016: Neural Regeneration Research
https://www.readbyqxmd.com/read/27689010/knockdown-of-atp-citrate-lyase-in-pancreatic-beta-cells-does-not-inhibit-insulin-secretion-or-glucose-flux-and-implicates-the-acetoacetate-pathway-in-insulin-secretion
#2
Mahmoud El Azzouny, Melissa J Longacre, Israr-Ul H Ansari, Robert T Kennedy, Charles F Burant, Michael J MacDonald
OBJECTIVE: Glucose-stimulated insulin secretion in pancreatic beta cells requires metabolic signals including the generation of glucose-derived short chain acyl-CoAs in the cytosol from mitochondrially-derived metabolites. One concept of insulin secretion is that ATP citrate lyase generates short chain acyl-CoAs in the cytosol from mitochondrially-derived citrate. Of these, malonyl-CoA, is believed to be an important signal in insulin secretion. Malonyl-CoA is also a precursor for lipids...
October 2016: Molecular Metabolism
https://www.readbyqxmd.com/read/27586962/suppression-of-fat-deposition-in-broiler-chickens-by-hydroxycitric-acid-supplementation-a-proteomics-perspective
#3
Mengling Peng, Jing Han, Longlong Li, Haitian Ma
(-)-Hydroxycitric acid (HCA) suppresses fatty acid synthesis in animals, but its biochemical mechanism in poultry is unclear. This study identified the key proteins associated with fat metabolism and elucidated the biochemical mechanism of (-)-HCA in broiler chickens. Four groups (n = 30 each) received a diet supplemented with 0, 1000, 2000 or 3000 mg/kg (-)-HCA for 4 weeks. Of the differentially expressed liver proteins, 40 and 26 were identified in the mitochondrial and cytoplasm respectively. Pyruvate dehydrogenase E1 components (PDHA1 and PDHB), dihydrolipoyl dehydrogenase (DLD), aconitase (ACO2), a-ketoglutarate dehydrogenase complex (DLST), enoyl-CoA hydratase (ECHS1) and phosphoglycerate kinase (PGK) were upregulated, while NADP-dependent malic enzyme (ME1) was downregulated...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27471516/organic-acids-the-pools-of-fixed-carbon-involved-in-redox-regulation-and-energy-balance-in-higher-plants
#4
REVIEW
Abir U Igamberdiev, Alexander T Eprintsev
Organic acids are synthesized in plants as a result of the incomplete oxidation of photosynthetic products and represent the stored pools of fixed carbon accumulated due to different transient times of conversion of carbon compounds in metabolic pathways. When redox level in the cell increases, e.g., in conditions of active photosynthesis, the tricarboxylic acid (TCA) cycle in mitochondria is transformed to a partial cycle supplying citrate for the synthesis of 2-oxoglutarate and glutamate (citrate valve), while malate is accumulated and participates in the redox balance in different cell compartments (via malate valve)...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27468467/identification-of-molecular-markers-to-study-the-garcinia-spp-diversity
#5
Utpala Parthasarathy, O P Nandakishore, O B Rosana, K Nirmal Babu, R Senthil Kumar, V A Parthasarathy
The genus Garcinia shows a considerable variation in its morphological characters such as leaf, flower and fruit with taxonomic ambiguity. It is a potential under-exploited multipurpose crop that gained considerable attention for the presence of (-) hydroxycitric acid, an anti-obesity compound, in its fruit rind and leaves. Here, we evaluated the genetic relationship through molecular markers among the selected 9 species commonly available in the Western Ghats and the Northeastern Himalayan foot hills of India...
June 2016: Indian Journal of Experimental Biology
https://www.readbyqxmd.com/read/27465721/nutrition-supplements-to-stimulate-lipolysis-a-review-in-relation-to-endurance-exercise-capacity
#6
Jisu Kim, Jonghoon Park, Kiwon Lim
Athletes make great efforts to increase their endurance capacity in many ways. Using nutrition supplements for stimulating lipolysis is one such strategy to improve endurance performance. These supplements contain certain ingredients that affect fat metabolism; furthermore, in combination with endurance training, they tend to have additive effects. A large body of scientific evidence shows that nutrition supplements increase fat metabolism; however, the usefulness of lipolytic supplements as ergogenic functional foods remains controversial...
2016: Journal of Nutritional Science and Vitaminology
https://www.readbyqxmd.com/read/27152103/acute-garcinia-mangostana-mangosteen-supplementation-does-not-alleviate-physical-fatigue-during-exercise-a-randomized-double-blind-placebo-controlled-crossover-trial
#7
Chih-Wei Chang, Tzu-Zung Huang, Wen-Hsin Chang, Yi-Chun Tseng, Yu-Tse Wu, Mei-Chich Hsu
BACKGROUND: The purple mangosteen (Garcinia mangostana), known as the "queen of fruit," is widely consumed and unique not only because of its outstanding appearance and flavor but also its remarkable and diverse pharmacological effects. The aim of the present study is to evaluate the effect of acute mangosteen supplementation on physical fatigue during exercise. METHODS: A randomized, double-blind, placebo-controlled, crossover study was carried out by 12 healthy adults...
2016: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/27145492/-hydroxycitric-acid-nourishes-protein-synthesis-via-altering-metabolic-directions-of-amino-acids-in-male-rats
#8
Ningning Han, Longlong Li, Mengling Peng, Haitian Ma
(-)-Hydroxycitric acid (HCA), a major active ingredient of Garcinia Cambogia extracts, had shown to suppress body weight gain and fat accumulation in animals and humans. While, the underlying mechanism of (-)-HCA has not fully understood. Thus, this study was aimed to investigate the effects of long-term supplement with (-)-HCA on body weight gain and variances of amino acid content in rats. Results showed that (-)-HCA treatment reduced body weight gain and increased feed conversion ratio in rats. The content of hepatic glycogen, muscle glycogen, and serum T4 , T3 , insulin, and Leptin were increased in (-)-HCA treatment groups...
August 2016: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/26974136/hydroxycitric-acid-ameliorates-high-fructose-induced-redox-imbalance-and-activation-of-stress-sensitive-kinases-in-male-wistar-rats
#9
Ramalingam Sripradha, Magadi Gopalakrishna Sridhar, Nachimuthu Maithilikarpagaselvi
BACKGROUND: Excess fructose consumption causes dyslipidemia, oxidative stress, and various complications. Hydroxycitric acid (HCA), one of the principal components of the fruit Garcinia cambogia, has been shown to possess antiobesity properties. The objective was to investigate the effects of HCA on redox imbalance and activation of stress sensitive kinases in high fructose-fed rats. METHODS: Male Wistar rats (n=40) were randomly divided into four groups with 10 rats in each group...
June 1, 2016: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/26912252/-hydroxycitric-acid-reduced-fat-deposition-via-regulating-lipid-metabolism-related-gene-expression-in-broiler-chickens
#10
Jing Han, Longlong Li, Dian Wang, Haitian Ma
BACKGROUND: Chicken as a delicious food for a long history, and it is well known that excess fat deposition in broiler chickens will not only induced metabolic diseases, but also lead to adverse effect in the consumer's health. (-)-Hydroxycitric acid (HCA), a major active ingredient of Garcinia Cambogia extracts, had shown to suppress fat accumulation in animals and humans. While, the precise physiological mechanism of HCA has not yet been full clarified, especially its action in broiler chickens...
2016: Lipids in Health and Disease
https://www.readbyqxmd.com/read/26792024/effects-of-intraduodenal-hydroxycitrate-on-glucose-absorption-incretin-release-and-glycemia-in-response-to-intraduodenal-glucose-infusion-in-health-and-type-2-diabetes-a-randomised-controlled-trial
#11
Sony S Thazhath, Tongzhi Wu, Michelle J Bound, Helen L Checklin, Scott Standfield, Karen L Jones, Michael Horowitz, Christopher K Rayner
OBJECTIVE: Hydroxycitric acid (HCA), derived from the fruit Garcinia cambogia, reduces the rate of glucose absorption and lowers postprandial glycemia in rodents, but its effect in humans is unknown. The aim of this study was to investigate the effects of small intestinal perfusion with HCA on glucose absorption, as well as the incretin and glycemic responses to a subsequent intraduodenal glucose infusion, in both healthy individuals and patients with type 2 diabetes. METHODS: Twelve healthy participants and 8 patients with type 2 diabetes received an intraduodenal infusion of HCA (2800 mg in water) or control (water) over 60 min, followed by an intraduodenal infusion of 60 g glucose over 120 min, in a double-blind, randomized crossover design...
May 2016: Nutrition
https://www.readbyqxmd.com/read/25879768/effect-of-organic-acids-on-calcium-phosphate-nucleation-and-osteogenic-differentiation-of-human-mesenchymal-stem-cells-on-peptide-functionalized-nanofibers
#12
Danial Barati, Joshua D Walters, Seyed Ramin Pajoum Shariati, Seyedsina Moeinzadeh, Esmaiel Jabbari
Carboxylate-rich organic acids play an important role in controlling the growth of apatite crystals and the extent of mineralization in the natural bone. The objective of this work was to investigate the effect of organic acids on calcium phosphate (CaP) nucleation on nanofiber microsheets functionalized with a glutamic acid peptide and osteogenic differentiation of human mesenchymal stem cells (hMSCs) seeded on the CaP-nucleated microsheets. High molecular weight poly(dl-lactide) (DL-PLA) was mixed with low molecular weight L-PLA conjugated with Glu-Glu-Gly-Gly-Cys peptide, and the mixture was electrospun to generate aligned nanofiber microsheets...
May 12, 2015: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/25732350/a-comprehensive-scientific-overview-of-garcinia-cambogia
#13
REVIEW
Ruchi Badoni Semwal, Deepak Kumar Semwal, Ilze Vermaak, Alvaro Viljoen
The fruit rind of Garcinia gummi-gutta, commonly known as Garcinia cambogia (syn.), is extensively used traditionally as a flavourant in fish curries due to its sharp sour taste. Additional ethnobotanical uses include its use as a digestive and a traditional remedy to treat bowel complaints, intestinal parasites and rheumatism. This small fruit, reminiscent of a pumpkin in appearance, is currently most popularly used and widely advertised as a weight-loss supplement. Studies have shown that the extracts as well as (-)-hydroxycitric acid (HCA), a main organic acid component of the fruit rind, exhibited anti-obesity activity including reduced food intake and body fat gain by regulating the serotonin levels related to satiety, increased fat oxidation and decreased de novo lipogenesis...
April 2015: Fitoterapia
https://www.readbyqxmd.com/read/25484097/caloric-restriction-mimetics-natural-physiological-pharmacological-autophagy-inducers
#14
EDITORIAL
Guillermo Mariño, Federico Pietrocola, Frank Madeo, Guido Kroemer
Nutrient depletion, which is one of the physiological triggers of autophagy, results in the depletion of intracellular acetyl coenzyme A (AcCoA) coupled to the deacetylation of cellular proteins. We surmise that there are 3 possibilities to mimic these effects, namely (i) the depletion of cytosolic AcCoA by interfering with its biosynthesis, (ii) the inhibition of acetyltransferases, which are enzymes that transfer acetyl groups from AcCoA to other molecules, mostly leucine residues in cellular proteins, or (iii) the stimulation of deacetylases, which catalyze the removal of acetyl groups from leucine residues...
2014: Autophagy
https://www.readbyqxmd.com/read/25296242/metabolomic-fingerprint-classification-of-brachychiton-acerifolius-organs-via-uplc-qtof-pda-ms-analysis-and-chemometrics
#15
Mohamed A Farag, Aisha H Abou Zeid, Manal A Hamed, Zeinab Kandeel, Hanaa M El-Rafie, Radwa H El-Akad
Brachychiton acerifolius, or Sterculia acerifolia as formerly known, is a member of a genus reported for a myriad of bioactive compounds. Metabolome analysis of B. acerifolius--leaves, flowers and seeds--and quantification of its major compounds are demonstrated in this study. Metabolites were analysed via UPLC-PDA-qTOF-(±) ESI-MS and UPLC/ITMS, with a total of 56 metabolites characterised including 30 flavonoids, 2 anthocyanins, 6 phenolic acids (i.e. citric and hydroxycitric acid conjugates) and 8 fatty acids (FAs)...
2015: Natural Product Research
https://www.readbyqxmd.com/read/25175938/-hydroxycitric-acid-attenuates-endoplasmic-reticulum-stress-mediated-alterations-in-3t3-l1-adipocytes-by-protecting-mitochondria-and-downregulating-inflammatory-markers
#16
V M Nisha, A Priyanka, S S Anusree, K G Raghu
Endoplasmic reticulum (ER) stress is an emerging potential therapeutic target for metabolic syndrome due to its role in synthesis, secretion, and folding of proteins. It leads to an increased production of reactive oxygen species (ROS) which, along with mitochondrial dysfunction and reduced antioxidant defense, causes chronic cell injury. The present investigation aims to observe the alterations in adipocytes due to ER stress and the protective effect of hydroxycitric acid (HCA), a bioactive from Garcinia species, to develop the same as a nutraceutical...
November 2014: Free Radical Research
https://www.readbyqxmd.com/read/25038696/hibiscus-sabdariffa-l-a-phytochemical-and-pharmacological-review
#17
REVIEW
Inês Da-Costa-Rocha, Bernd Bonnlaender, Hartwig Sievers, Ivo Pischel, Michael Heinrich
Hibiscus sabdariffa L. (Hs, roselle; Malvaceae) has been used traditionally as a food, in herbal drinks, in hot and cold beverages, as a flavouring agent in the food industry and as a herbal medicine. In vitro and in vivo studies as well as some clinical trials provide some evidence mostly for phytochemically poorly characterised Hs extracts. Extracts showed antibacterial, anti-oxidant, nephro- and hepato-protective, renal/diuretic effect, effects on lipid metabolism (anti-cholesterol), anti-diabetic and anti-hypertensive effects among others...
December 15, 2014: Food Chemistry
https://www.readbyqxmd.com/read/24944404/effects-of-garcinia-cambogia-hydroxycitric-acid-on-visceral-fat-accumulation-a-double-blind-randomized-placebo-controlled-trial
#18
Kohsuke Hayamizu, Yuri Ishii, Izuru Kaneko, Manzhen Shen, Yasuhide Okuhara, Norihiro Shigematsu, Hironori Tomi, Mitsuhiro Furuse, Gen Yoshino, Hiroyuki Shimasaki
BACKGROUND: (-)-Hydroxycitric acid (HCA) is an active ingredient extracted from the rind of the Indian fruit Garcinia cambogia. It inhibits adenosine triphosphate citrate lyase and has been used in the treatment of obesity. OBJECTIVE: The primary end point of this study was the effects of 12 weeks of G cambogia extract administration on visceral fat accumulation. The secondary end points were body indices (including height, body weight, body mass index [BMI], waist and hip circumference, and waist-hip ratio) and laboratory values (including total cholesterol, triacylglycerol, and free fatty acid)...
September 2003: Current Therapeutic Research, Clinical and Experimental
https://www.readbyqxmd.com/read/24511042/metabolic-treatment-of-cancer-intermediate-results-of-a-prospective-case-series
#19
Laurent Schwartz, Ludivine Buhler, Philippe Icard, Hubert Lincet, Jean-Marc Steyaert
BACKGROUND: The combination of hydroxycitrate and lipoic acid has been demonstrated by several laboratories to be effective in reducing murine cancer growth. PATIENTS AND METHODS: All patients had failed standard chemotherapy and were offered only palliative care by their referring oncologist. Karnofsky status was between 50 and 80. Life expectancy was estimated to be between 2 and 6 months. Ten consecutive patients with chemoresistant advanced metastatic cancer were offered compassionate metabolic treatment...
February 2014: Anticancer Research
https://www.readbyqxmd.com/read/24133059/hypolipemic-effect-of-garcinia-cambogia-in-obese-women
#20
RANDOMIZED CONTROLLED TRIAL
Carlos A R Vasques, Ricardo Schneider, Luiz C Klein-Júnior, Andressa Falavigna, Ivone Piazza, Simone Rossetto
Garcinia cambogia seems to promote weight reduction and improvement on lipid profile by its major compound, hydroxycitric acid (HCA), blocking ATP-citratelyase, potentially inhibiting lipogenesis. Furthermore, it is suggested that its extract is able to change the adipokine levels. Thus, the aim of this study was to analyse the effect of G. cambogia on the lipid profile, endocrine, calorimetric and anthropometric parameters of obese women. The women (BMI > 25 kg/m(2) ; age 25-60 years), divided in treated (n = 30) and control (n = 13) groups, received 2...
June 2014: Phytotherapy Research: PTR
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