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https://www.readbyqxmd.com/read/28804986/effects-of-hydroxycitric-acid-on-lipid-droplet-accumulation-in-chicken-embryos
#1
Mengling Peng, Longlong Li, Lei Yu, Chongyang Ge, Haitian Ma
This study was conducted to determine the impact of (-)-hydroxycitric acid ((-)-HCA) on biochemical indices and lipid metabolism parameters in chicken embryos. Two hundred and forty fertilized eggs were divided into six groups and injected with (-)-HCA at concentrations of 0, 0.1, 0.5, 1.0, 10.0 and 50 mg/kg (n = 40). After 19 days of incubation, serum and liver were collected for analysis of biochemical indices and lipid metabolism parameters. Results showed no significant differences on serum biochemical indices: 1-50 mg/kg (-)-HCA significantly increased serum glucose and hepatic glycogen contents (P < 0...
August 14, 2017: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/28777081/binding-of-hydroxycitrate-to-human-atp-citrate-lyase
#2
Jinhong Hu, Aruna Komakula, Marie E Fraser
Hydroxycitrate from the fruit of Garcinia cambogia [i.e. (2S,3S)-2-hydroxycitrate] is the best-known inhibitor of ATP-citrate lyase. Well diffracting crystals showing how the inhibitor binds to human ATP-citrate lyase were grown by modifying the protein. The protein was modified by introducing cleavage sites for Tobacco etch virus protease on either side of a disordered linker. The protein crystallized consisted of residues 2-425-ENLYFQ and S-488-810 of human ATP-citrate lyase. (2S,3S)-2-Hydroxycitrate binds in the same orientation as citrate, but the citrate-binding domain (residues 248-421) adopts a different orientation with respect to the rest of the protein (residues 4-247, 490-746 and 748-809) from that previously seen...
August 1, 2017: Acta Crystallographica. Section D, Structural Biology
https://www.readbyqxmd.com/read/28636136/capillary-zone-electrophorsis-for-the-analysis-of-naturally-occurring-2-hydroxycitric-acids-and-their-lactones
#3
B L Abhijith, Moolya Mohan, David Joseph, Simimole Haleema, Hassan Y Aboul-Enein, Ibrahim Ibnusaud
A simple capillary zone electrophoresis method with direct ultraviolet detection has been developed for the analysis of naturally occurring diastereomeric 2-hydroxycitric acid lactones. Using 50 mM sodium phosphate buffer of pH 7, a baseline resolution Rs > 3.0 was observed for all organic acids selected for the present study. This method was employed for the quantitative determination of title acids present in the plant sources namely G. cambogia fruit rinds and H. sabdariffa calyx. Conversion of 2-hydroxycitric acids to their lactones on heating above plant sources is deliberated...
June 21, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28326002/anti-obesity-effect-of-solidago-virgaurea-var-gigantea-extract-through-regulation-of-adipogenesis-and-lipogenesis-pathways-in-high-fat-diet-induced-obese-mice-c57bl-6n
#4
Zhiqiang Wang, Ju Hee Kim, Young Soo Jang, Chea Ha Kim, Jae-Yong Lee, Soon Sung Lim
Background: Obesity is associated with an increase in adipogenesis and is becoming a serious health problem in modern society. Objective: The effects of various Solidago virgaurea var. gigantean (SV) ethanolic aqueous extracts on anti-adipogenesis in 3T3-L1 cells were investigated. In addition, the effect of SV 10% ethanolic extract (SV10E) on preventing obesity was studied in high-fat diet-induced obese mice (C57BL/6 N). Design: The effect of SV10E on preventing obesity was studied in mice (n = 6): normal-fat diet, high-fat diet (HFD), HFD supplemented with 1% (10 g/kg) Garcinia cambogia extract of 60% (-)-hydroxycitric acid (positive control), HFD supplemented with 0...
2017: Food & Nutrition Research
https://www.readbyqxmd.com/read/28322589/comparison-of-metabolic-profiles-and-bioactivities-of-the-leaves-of-three-edible-congolese-hibiscus-species
#5
Paulin Mutwale Kapepula, Nadege Kabamba Ngombe, Pascal Tshisekedi Tshibangu, César Tsumbu, Thierry Franck, Ange Mouithys-Mickalad, Dieudonné Mumba, Désiré Tshala-Katumbay, Didier Serteyn, Monique Tits, Luc Angenot, Pascal Dibungi T Kalenda, Michel Frédérich
Methanolic and dichloromethane extracts from the leaves of Congolese Hibiscus species were characterised by chromatographic and spectroscopic techniques and their in vitro biochemical activities against ROS production were evaluated in cellular models and on an enzyme, myeloperoxidase (MPO), involved in inflammation. Hibiscus acetosella has a chemical fingerprint different from Hibiscus cannabinus and Hibiscus sabdariffa both having similar fingerprints. Major compounds were polyphenols, represented mainly by caffeoyl-hydroxycitric acid for H...
March 21, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28288493/inhibitory-effects-of-garcinia-cambogia-extract-on-cyp2b6-enzyme-activity
#6
Jun Sang Yu, Min Sun Choi, Jong Suk Park, Shaheed Ur Rehman, Katsunori Nakamura, Hye Hyun Yoo
This study assessed the inhibitory effects of Garcinia cambogia extract on the cytochrome P450 enzymes in vitro. G. cambogia extract was incubated with cytochrome P450 isozyme-specific substrates in human liver microsomes and recombinant CYP2B6 isozyme, and the formation of the marker metabolites was measured to investigate the inhibitory potential on cytochrome P450 enzyme activities. The results showed that G. cambogia extract has significant inhibitory effects on CYP2B6 activity in a concentration-dependent manner...
July 2017: Planta Medica
https://www.readbyqxmd.com/read/28271601/phytochemical-compounds-in-sport-nutrition-synephrine-and-hydroxycitric-acid-hca-as-examples-for-evaluation-of-possible-health-risks
#7
REVIEW
Nadiya Bakhiya, Rainer Ziegenhagen, Karen I Hirsch-Ernst, Birgit Dusemund, Klaus Richter, Katharina Schultrich, Sophie Pevny, Bernd Schäfer, Alfonso Lampen
Numerous food supplements contain phytochemical compounds as active ingredients. Although such supplements are often perceived by consumers as being risk-free, the safety of many of them is currently uncertain. The present review provides two examples for risk assessment for phytochemical ingredients that are used in certain supplements marketed for sportspeople-synephrine (extracted from fruits of Citrus aurantium) and hydroxycitric acid (HCA, isolated from fruits of Garcinia cambogia). Animal and human studies, as well as case reports, provide evidence for cardiovascular effects due to ingestion of high synephrine doses, especially in combination with caffeine and physical exertion...
June 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28122260/out-of-warburg-effect-an-effective-cancer-treatment-targeting-the-tumor-specific-metabolism-and-dysregulated-ph
#8
REVIEW
Laurent Schwartz, Thomas Seyfried, Khalid O Alfarouk, Jorgelindo Da Veiga Moreira, Stefano Fais
As stated by Otto Warburg nearly a century ago, cancer is a metabolic disease, a fermentation caused by malfunctioning mitochondria, resulting in increased anabolism and decreased catabolism. Treatment should, therefore, aim at restoring the energy yield. To decrease anabolism, glucose uptake should be reduced (ketogenic diet). To increase catabolism, the oxidative phosphorylation should be restored. Treatment with a combination of α-lipoic acid and hydroxycitrate has been shown to be effective in multiple animal models...
April 2017: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/28018115/dangerous-dietary-supplements-garcinia-cambogia-associated-hepatic-failure-requiring-transplantation
#9
Keri E Lunsford, Adam S Bodzin, Diego C Reino, Hanlin L Wang, Ronald W Busuttil
Commercial dietary supplements are marketed as a panacea for the morbidly obese seeking sustainable weight-loss. Unfortunately, many claims cited by supplements are unsupported and inadequately regulated. Most concerning, however, are the associated harmful side effects, often unrecognized by consumers. Garcinia cambogia extract and Garcinia cambogia containing products are some of the most popular dietary supplements currently marketed for weight loss. Here, we report the first known case of fulminant hepatic failure associated with this dietary supplement...
December 7, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27904492/hydroxycitric-acid-ameliorates-inflammation-and-oxidative-stress-in-mouse-models-of-multiple-sclerosis
#10
Mahdi Goudarzvand, Sanaz Afraei, Somaye Yaslianifard, Saleh Ghiasy, Ghazal Sadri, Mustafa Kalvandi, Tina Alinia, Ali Mohebbi, Reza Yazdani, Shahin Khadem Azarian, Abbas Mirshafiey, Gholamreza Azizi
Hydroxycitric acid (HCA) is derived primarily from the Garcinia plant and is widely used for its anti-inflammatory effects. Multiple sclerosis can cause an inflammatory demyelination and axonal damage. In this study, to validate the hypothesis that HCA exhibits therapeutic effects on multiple sclerosis, we established female C57BL/6 mouse models of multiple sclerosis, i.e., experimental autoimmune encephalomyelitis, using Complete Freund's Adjuvant (CFA) emulsion containing myelin oligodendrocyte glycoprotein (35-55)...
October 2016: Neural Regeneration Research
https://www.readbyqxmd.com/read/27689010/knockdown-of-atp-citrate-lyase-in-pancreatic-beta-cells-does-not-inhibit-insulin-secretion-or-glucose-flux-and-implicates-the-acetoacetate-pathway-in-insulin-secretion
#11
Mahmoud El Azzouny, Melissa J Longacre, Israr-Ul H Ansari, Robert T Kennedy, Charles F Burant, Michael J MacDonald
OBJECTIVE: Glucose-stimulated insulin secretion in pancreatic beta cells requires metabolic signals including the generation of glucose-derived short chain acyl-CoAs in the cytosol from mitochondrially-derived metabolites. One concept of insulin secretion is that ATP citrate lyase generates short chain acyl-CoAs in the cytosol from mitochondrially-derived citrate. Of these, malonyl-CoA, is believed to be an important signal in insulin secretion. Malonyl-CoA is also a precursor for lipids...
October 2016: Molecular Metabolism
https://www.readbyqxmd.com/read/27586962/suppression-of-fat-deposition-in-broiler-chickens-by-hydroxycitric-acid-supplementation-a-proteomics-perspective
#12
Mengling Peng, Jing Han, Longlong Li, Haitian Ma
(-)-Hydroxycitric acid (HCA) suppresses fatty acid synthesis in animals, but its biochemical mechanism in poultry is unclear. This study identified the key proteins associated with fat metabolism and elucidated the biochemical mechanism of (-)-HCA in broiler chickens. Four groups (n = 30 each) received a diet supplemented with 0, 1000, 2000 or 3000 mg/kg (-)-HCA for 4 weeks. Of the differentially expressed liver proteins, 40 and 26 were identified in the mitochondrial and cytoplasm respectively. Pyruvate dehydrogenase E1 components (PDHA1 and PDHB), dihydrolipoyl dehydrogenase (DLD), aconitase (ACO2), a-ketoglutarate dehydrogenase complex (DLST), enoyl-CoA hydratase (ECHS1) and phosphoglycerate kinase (PGK) were upregulated, while NADP-dependent malic enzyme (ME1) was downregulated...
September 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27471516/organic-acids-the-pools-of-fixed-carbon-involved-in-redox-regulation-and-energy-balance-in-higher-plants
#13
REVIEW
Abir U Igamberdiev, Alexander T Eprintsev
Organic acids are synthesized in plants as a result of the incomplete oxidation of photosynthetic products and represent the stored pools of fixed carbon accumulated due to different transient times of conversion of carbon compounds in metabolic pathways. When redox level in the cell increases, e.g., in conditions of active photosynthesis, the tricarboxylic acid (TCA) cycle in mitochondria is transformed to a partial cycle supplying citrate for the synthesis of 2-oxoglutarate and glutamate (citrate valve), while malate is accumulated and participates in the redox balance in different cell compartments (via malate valve)...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27468467/identification-of-molecular-markers-to-study-the-garcinia-spp-diversity
#14
Utpala Parthasarathy, O P Nandakishore, O B Rosana, K Nirmal Babu, R Senthil Kumar, V A Parthasarathy
The genus Garcinia shows a considerable variation in its morphological characters such as leaf, flower and fruit with taxonomic ambiguity. It is a potential under-exploited multipurpose crop that gained considerable attention for the presence of (-) hydroxycitric acid, an anti-obesity compound, in its fruit rind and leaves. Here, we evaluated the genetic relationship through molecular markers among the selected 9 species commonly available in the Western Ghats and the Northeastern Himalayan foot hills of India...
June 2016: Indian Journal of Experimental Biology
https://www.readbyqxmd.com/read/27465721/nutrition-supplements-to-stimulate-lipolysis-a-review-in-relation-to-endurance-exercise-capacity
#15
REVIEW
Jisu Kim, Jonghoon Park, Kiwon Lim
Athletes make great efforts to increase their endurance capacity in many ways. Using nutrition supplements for stimulating lipolysis is one such strategy to improve endurance performance. These supplements contain certain ingredients that affect fat metabolism; furthermore, in combination with endurance training, they tend to have additive effects. A large body of scientific evidence shows that nutrition supplements increase fat metabolism; however, the usefulness of lipolytic supplements as ergogenic functional foods remains controversial...
2016: Journal of Nutritional Science and Vitaminology
https://www.readbyqxmd.com/read/27152103/acute-garcinia-mangostana-mangosteen-supplementation-does-not-alleviate-physical-fatigue-during-exercise-a-randomized-double-blind-placebo-controlled-crossover-trial
#16
RANDOMIZED CONTROLLED TRIAL
Chih-Wei Chang, Tzu-Zung Huang, Wen-Hsin Chang, Yi-Chun Tseng, Yu-Tse Wu, Mei-Chich Hsu
BACKGROUND: The purple mangosteen (Garcinia mangostana), known as the "queen of fruit," is widely consumed and unique not only because of its outstanding appearance and flavor but also its remarkable and diverse pharmacological effects. The aim of the present study is to evaluate the effect of acute mangosteen supplementation on physical fatigue during exercise. METHODS: A randomized, double-blind, placebo-controlled, crossover study was carried out by 12 healthy adults...
2016: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/27145492/-hydroxycitric-acid-nourishes-protein-synthesis-via-altering-metabolic-directions-of-amino-acids-in-male-rats
#17
Ningning Han, Longlong Li, Mengling Peng, Haitian Ma
(-)-Hydroxycitric acid (HCA), a major active ingredient of Garcinia Cambogia extracts, had shown to suppress body weight gain and fat accumulation in animals and humans. While, the underlying mechanism of (-)-HCA has not fully understood. Thus, this study was aimed to investigate the effects of long-term supplement with (-)-HCA on body weight gain and variances of amino acid content in rats. Results showed that (-)-HCA treatment reduced body weight gain and increased feed conversion ratio in rats. The content of hepatic glycogen, muscle glycogen, and serum T4 , T3 , insulin, and Leptin were increased in (-)-HCA treatment groups...
August 2016: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/26974136/hydroxycitric-acid-ameliorates-high-fructose-induced-redox-imbalance-and-activation-of-stress-sensitive-kinases-in-male-wistar-rats
#18
Ramalingam Sripradha, Magadi Gopalakrishna Sridhar, Nachimuthu Maithilikarpagaselvi
BACKGROUND: Excess fructose consumption causes dyslipidemia, oxidative stress, and various complications. Hydroxycitric acid (HCA), one of the principal components of the fruit Garcinia cambogia, has been shown to possess antiobesity properties. The objective was to investigate the effects of HCA on redox imbalance and activation of stress sensitive kinases in high fructose-fed rats. METHODS: Male Wistar rats (n=40) were randomly divided into four groups with 10 rats in each group...
June 1, 2016: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/26912252/-hydroxycitric-acid-reduced-fat-deposition-via-regulating-lipid-metabolism-related-gene-expression-in-broiler-chickens
#19
Jing Han, Longlong Li, Dian Wang, Haitian Ma
BACKGROUND: Chicken as a delicious food for a long history, and it is well known that excess fat deposition in broiler chickens will not only induced metabolic diseases, but also lead to adverse effect in the consumer's health. (-)-Hydroxycitric acid (HCA), a major active ingredient of Garcinia Cambogia extracts, had shown to suppress fat accumulation in animals and humans. While, the precise physiological mechanism of HCA has not yet been full clarified, especially its action in broiler chickens...
February 24, 2016: Lipids in Health and Disease
https://www.readbyqxmd.com/read/26792024/effects-of-intraduodenal-hydroxycitrate-on-glucose-absorption-incretin-release-and-glycemia-in-response-to-intraduodenal-glucose-infusion-in-health-and-type-2-diabetes-a-randomised-controlled-trial
#20
RANDOMIZED CONTROLLED TRIAL
Sony S Thazhath, Tongzhi Wu, Michelle J Bound, Helen L Checklin, Scott Standfield, Karen L Jones, Michael Horowitz, Christopher K Rayner
OBJECTIVE: Hydroxycitric acid (HCA), derived from the fruit Garcinia cambogia, reduces the rate of glucose absorption and lowers postprandial glycemia in rodents, but its effect in humans is unknown. The aim of this study was to investigate the effects of small intestinal perfusion with HCA on glucose absorption, as well as the incretin and glycemic responses to a subsequent intraduodenal glucose infusion, in both healthy individuals and patients with type 2 diabetes. METHODS: Twelve healthy participants and 8 patients with type 2 diabetes received an intraduodenal infusion of HCA (2800 mg in water) or control (water) over 60 min, followed by an intraduodenal infusion of 60 g glucose over 120 min, in a double-blind, randomized crossover design...
May 2016: Nutrition
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