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Aida Castellanos, Alba Andres, Laura Bernal, Gerard Callejo, Nuria Comes, Arcadi Gual, Jonathan P Giblin, Carolina Roza, Xavier Gasull
Pyrethroid insecticides are widely used for pest control, in agriculture or in human public health commonly as a topical treatment for scabies and head lice. Exposure to pyrethroids such as permethrin or tetramethrin (TM) causes sensory alterations such as transient pain, burning, stinging sensations and paraesthesias. Despite the well-known effects of pyrethroids on sodium channels, actions on other channels that control sensory neuron excitability are less studied. Given the role of two-pore domain potassium (K2P) channels in modulating sensory neuron excitability and firing, both in physiological and pathological conditions, we examined the effect of pyrethroids on K2P channels mainly expressed in sensory neurons...
September 19, 2017: Pain
Natasha M Agramonte, Jeffrey R Bloomquist, Ulrich R Bernier
Emerging insecticide resistance is a major issue for vector control. It decreases the effectiveness of insecticides, thereby requiring greater quantities for comparable control with a net increase in risk of disease resurgence, product cost, and damage risk to the ecosystem. Pyrethroid resistance has been documented in Puerto Rican populations of Aedes aegypti (L.) mosquitoes. In this study, topical toxicity of five insecticides (permethrin, etofenprox, deltamethrin, DDT, transfluthrin) was determined for susceptible (Orlando-ORL) and resistant (Puerto Rico-PR) strains of Ae...
September 20, 2017: PLoS Neglected Tropical Diseases
Mustafa Şengül, Nida Kaçar, Mehmet Karaca, Sedef Zeliha Öner, Çağrı Ergin
Dermanyssus gallinae is one of the important hematophagous ectoparasite species of poultry like chicken, pigeon and wild bird species. These ectoparasites in the form of nymphs or adults who can not find their hosts are also seen in mammals and even in humans. For this reason, they are considered as important for public health. The ectoparasite causes a clinical condition named gamasoidosis among pet owners and people who live or work close to animal shelters, barns and chicken farms. Pruritus dermatitis is also caused by D...
July 2017: Mikrobiyoloji Bülteni
Tobias Suter, Mônica Maria Crespo, Mariana Francelino de Oliveira, Thaynan Sama Alves de Oliveira, Maria Alice Varjal de Melo-Santos, Cláudia Maria Fontes de Oliveira, Constância Flávia Junqueira Ayres, Rosângela Maria Rodrigues Barbosa, Ana Paula Araújo, Lêda Narcisa Regis, Eleonora Flacio, Lukas Engeler, Pie Müller, Maria Helena Neves Lobo Silva-Filha
BACKGROUND: Aedes aegypti and Ae. albopictus are two highly invasive mosquito species, both vectors of several viruses, including dengue, chikungunya and Zika. While Ae. aegypti is the primary vector in the tropics and sub-tropics, Ae. albopictus is increasingly under the public health watch as it has been implicated in arbovirus-transmission in more temperate regions, including continental Europe. Vector control using insecticides is the pillar of most control programmes; hence development of insecticide resistance is of great concern...
September 19, 2017: Parasites & Vectors
Heike Kohler-Aanesen, Seppo Saari, Rob Armstrong, Karine Péré, Janina Taenzler, Eva Zschiesche, Anja R Heckeroth
BACKGROUND: The clinical efficacy of fluralaner chewable tablets (Bravecto™, MSD Animal Health) against naturally acquired Linognathus setosus infestations on dogs was evaluated compared with permethrin (Exspot®, MSD Animal Health) treatment. METHODS: Privately-owned dogs naturally infested with L. setosus from 21 different households were randomly allocated to two treatment groups. Fourteen dogs were treated once orally with fluralaner and ten dogs were treated once topically with permethrin, at the recommended label dose...
September 18, 2017: Parasites & Vectors
Kadarkarai Murugan, Udaiyan Suresh, Chellasamy Panneerselvam, Rajapandian Rajaganesh, Mathath Roni, Al Thabiani Aziz, Jiang-Shiou Hwang, Kuppusamy Sathishkumar, Aruliah Rajasekar, Suresh Kumar, Abdullah A Alarfaj, Akon Higuchi, Giovanni Benelli
The development of novel mosquito control tools is a key prerequisite to build effective and reliable Integrated Vector Management strategies. Here, we proposed a novel method using cigarette butts for the synthesis of Ag nanostructures toxic to young instars of the malaria vector Anopheles stephensi, chloroquine (CQ)-resistant malaria parasites Plasmodium falciparum and microbial pathogens. The non-target impact of these nanomaterials in the aquatic environment was evaluated testing them at sub-lethal doses on the predatory copepod Mesocyclops aspericornis...
September 14, 2017: Environmental Science and Pollution Research International
Saada Mbepera, Gamba Nkwengulila, Rose Peter, Emmanuel A Mausa, Aneth M Mahande, Maureen Coetzee, Eliningaya J Kweka
BACKGROUND: Insecticide resistance is the major emerging challenge facing the malaria vector control programmes in Tanzania. Proper monitoring and detection is of paramount importance guiding the vector control programmes. This paper presents the effect of mosquito aging on insecticide resistance status in Anopheles arabiensis populations in dry and rainy seasons in northern Tanzania. METHODS: Anopheles gambiae s.l. larvae were sampled from rice fields in both dry and rainy seasons and reared in the insectary to adults...
September 11, 2017: Malaria Journal
Linda A Deanovic, Marie Stillway, Bruce G Hammock, Stephanie Fong, Inge Werner
Pyrethroid insecticides are commonly used in pest control and are present at toxic concentrations in surface waters of agricultural and urban areas worldwide. Monitoring is challenging due to their high hydrophobicity and low toxicity thresholds, which often fall below the detection limits of analytical methods. Standard daphnid bioassays used in surface water monitoring are not sensitive enough to protect more susceptible invertebrate species such as the amphipod, Hyalella azteca, and chemical loss during toxicity testing is of concern...
September 9, 2017: Environmental Toxicology and Chemistry
Elinas J Nnko, Charles Kihamia, Filemoni Tenu, Zul Premji, Eliningaya J Kweka
BACKGROUND: Evidence of insecticide resistance has been documented in different malaria endemic areas. Surveillance studies to allow prompt investigation of associated factors to enable effective insecticide resistance management are needed. The objective of this study was to assess insecticide use pattern and phenotypic susceptibility level of Anopheles gambiae sensu lato to insecticides commonly used in malaria control in Moshi, northern Tanzania. METHODS: A cross-sectional survey was conducted to assess insecticide usage pattern...
September 6, 2017: BMC Research Notes
Gerwin Louis Tapan Dela Torre, Kerstin Mariae Gonzales Ponsaran, Angelica Louise Dela Peña de Guzman, Richelle Ann Mallapre Manalo, Erna Custodio Arollado
The high prevalence of pediculosis capitis, commonly known as head lice (Pediculus humanus capitis) infestation, has led to the preparation of a community-based pediculicidal ointment, which is made of common household items and the extract of Tinospora crispa stem. The present study aimed to evaluate the safety, efficacy, and physicochemical characteristics of the T. crispa pediculicidal ointment. The physicochemical properties of the ointment were characterized, and safety was determined using acute dermal irritation test (OECD 404), while the efficacy was assessed using an in vitro pediculicidal assay...
August 2017: Korean Journal of Parasitology
Xiao Xiao, Weipeng Qi, John M Clark, Yeonhwa Park
Permethrin, a pyrethroid insecticide, was previously reported to promote adipogenesis in vitro and weight gain in vivo. The mechanism by which permethrin promotes adipogenesis/obesity, however, has not been fully explored. Intracellular calcium and endoplasmic reticulum (ER) stress have been reported to be linked with adipogenesis and obesity. Because pyrethroid insecticides have been determined to influence intracellular calcium and ER stress in vitro, the purpose of this current study was to investigate whether permethrin potentiates adipogenesis via a change in intracellular calcium, leading to endoplasmic reticulum (ER) stress in 3T3-L1 adipocytes...
September 6, 2017: Food and Chemical Toxicology
Leila Shirani-Bidabadi, Alireza Zahraei-Ramazani, Mohammad Reza Yaghoobi-Ershadi, Yavar Rassi, Amir Ahmad Akhavan, Mohammad Ali Oshaghi, Ahmad Ali Enayati, Zahra Saeidi, Reza Jafari, Hassan Vatandoost
Leishmaniasis is a Neglected Tropical Disease (NTD) and emerging parasitic infection that affect mainly poor regions around the world. This study aimed to determine the baseline susceptibility of Phlebotomus papatasi to commonly used insecticides in a hyper endemic area using WHO standard procedure in central Iran. A total of 4-5 replicates containing 120-200 sand flies were used for each insecticide. Baseline susceptibility to DDT and pyrethroids was assessed on 5326 specimens collected from the study area...
September 8, 2017: Acta Tropica
Hirokatsu Saito, Kenshiro Hara, Kentaro Tanemura
Permethrin, a pyrethroid chemical, is widely used as a pesticide because of its rapid insecticidal activity. Although permethrin is considered to exert very low toxicity on mammalian reproductive organs, the effects of early low-level and chronic exposure on adult spermatogenesis are unclear. We exposed mice to environmentally relevant concentrations of permethrin (0, 0.3, and 30ppm) in drinking water during prenatal and postnatal period and examined the effects on the testis in mice offspring when they reached maturity (12 weeks of age)...
September 1, 2017: Reproductive Toxicology
Quancai Sun, Ye Peng, Weipeng Qi, Yoo Kim, John M Clark, Daeyoung Kim, Yeonhwa Park
Previously 10 μM permethrin (38.7% cis and 59.4% trans isomers), a pyrethroid insecticide widely used in agriculture and household products for pest control, was reported to reduce insulin-stimulated glucose uptake and phosphorylation of protein kinase B (p-AKT) in C2C12 mouse myotubes. The underlying mechanisms on how permethrin decreases insulin-stimulated AKT phosphorylation, however, are unknown. Thus, the goal of this study was to determine the possible mechanism(s) through which permethrin reduced insulin-stimulated AKT phosphorylation in C2C12 myotubes...
September 1, 2017: Food and Chemical Toxicology
Sheena Francis, Karla Saavedra-Rodriguez, Rushika Perera, Mark Paine, William C Black, Rupika Delgoda
[This corrects the article DOI: 10.1371/journal.pone.0179673.].
2017: PloS One
Victoria A Ingham, Patricia Pignatelli, Jonathan D Moore, Simon Wagstaff, Hilary Ranson
BACKGROUND: Malaria control in Africa is dependent upon the use insecticides but intensive use of a limited number of chemicals has led to resistance in mosquito populations. Increased production of enzymes that detoxify insecticides is one of the most potent resistance mechanisms. Several metabolic enzymes have been implicated in insecticide resistance but the processes controlling their expression have remained largely elusive. RESULTS: Here, we show that the transcription factor Maf-S regulates expression of multiple detoxification genes, including the key insecticide metabolisers CYP6M2 and GSTD1 in the African malaria vector Anopheles gambiae...
August 30, 2017: BMC Genomics
Junaid Rahim, Abu H Ahmad, Hamdan Ahmad, Intan H Ishak, Adanan Che Rus, Hamisu A Maimusa
Insecticide-based vector control approaches are facing challenges due to the development of resistance in vector mosquitoes. Therefore, a proper resistance surveillance program using baseline lethal concentrations is crucial for resistance management strategies. Currently, the World Health Organization's (WHO) diagnostic doses established for Aedes aegypti and Anopheles species are being used to study the resistance status of Aedes albopictus. In this study, we established the diagnostic doses for permethrin, deltamethrin, and malathion using a known susceptible reference strain...
September 2017: Journal of the American Mosquito Control Association
Muhammad Farooq, Ali Fulcher, Rui-De Xue, Michael L Smith, Jeremy L Anderson, Alex R Richardson, Jennifer A Knapp
Inconsistencies in efficacy of ultra-low volume (ULV) ground applications in the literature are linked to the lack of adjustments in sprayer parameters. To investigate the effect of nozzle orientation of a truck-mounted ULV sprayer on application efficacy, a study was conducted at St. Johns County Fairground, Elkton, FL, during the summer of 2014. The efficacy was assessed by mortality of caged adult Aedes aegypti, spray deposition, and droplet size spectrum up to 122 m from the spray line. Aqualuer 20-20 (20...
September 2017: Journal of the American Mosquito Control Association
Jean-Desire Rakotoson, Christen M Fornadel, Allison Belemvire, Laura C Norris, Kristen George, Angela Caranci, Bradford Lucas, Dereje Dengela
BACKGROUND: Insecticide-based vector control, which comprises use of insecticide-treated bed nets (ITNs) and indoor residual spraying (IRS), is the key method to malaria control in Madagascar. However, its effectiveness is threatened as vectors become resistant to insecticides. This study investigated the resistance status of malaria vectors in Madagascar to various insecticides recommended for use in ITNs and/or IRS. METHODS: WHO tube and CDC bottle bioassays were performed on populations of Anopheles gambiae (s...
August 23, 2017: Parasites & Vectors
Matteo Anaclerio, Marco Pellizzoni, Valeria Todeschini, David Kane, Ahmad Hanafi, Marco Trevisan, Lucini Luigi
BACKGROUND: Pest control in post-harvest food storage represents a great challenge in the sustainable prevention of food losses, and insecticide-treated netting may represent a valid alternative to traditional practices such as direct application of insecticides. In our work, the efficacy of a permethrin-incorporated net, in combination with polypropylene or jute sacking, was tested, for the control of S. oryzae. Contamination of maize grain by permethrin from the treated netting was also evaluated...
August 23, 2017: Pest Management Science
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