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https://www.readbyqxmd.com/read/28624474/-exposure-to-the-insecticides-permethrin-and-malathion-induces-leukemia-and-lymphoma-associated-gene-aberrations-in-vitro
#1
M P Navarrete-Meneses, C Salas-Labadía, M Sanabrais-Jiménez, J Santana-Hernández, A Serrano-Cuevas, R Juárez-Velázquez, A Olaya-Vargas, P Pérez-Vera
Epidemiological studies have associated the exposure to permethrin and malathion with increased risk of leukemia and lymphoma. The aim of this study was to evaluate whether in vitro exposure to permethrin and malathion induces aberrations in genes involved in the etiology of these hematological malignancies. Genetic abnormalities in the IGH, KMT2A (MLL), ETV6 and RUNX1 genes; and aneuploidy induced by the in vitro exposure to permethrin and malathion (200μM, 24h), were analyzed by FISH in peripheral blood mononuclear cells (PBMCs)...
June 14, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28623302/insecticide-susceptibility-of-anopheles-mosquitoes-changes-in-response-to-variations-in-the-larval-environment
#2
Henry F Owusu, Nakul Chitnis, Pie Müller
Insecticide resistance threatens the success achieved through vector control in reducing the burden of malaria. An understanding of insecticide resistance mechanisms would help to develop novel tools and strategies to restore the efficacy of insecticides. Although we have substantially improved our understanding of the genetic basis of insecticide resistance over the last decade, we still know little of how environmental variations influence the mosquito phenotype. Here, we measured how variations in larval rearing conditions change the insecticide susceptibility phenotype of adult Anopheles mosquitoes...
June 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28622373/a-versatile-and-low-cost-open-source-pipetting-robot-for-automation-of-toxicological-and-ecotoxicological-bioassays
#3
Sebastian Steffens, Leonie Nüßer, Thomas-Benjamin Seiler, Nadine Ruchter, Mark Schumann, Ricarda Döring, Catrina Cofalla, Avi Ostfeld, Elad Salomons, Holger Schüttrumpf, Henner Hollert, Markus Brinkmann
In the past decades, bioassays and whole-organism bioassay have become important tools not only in compliance testing of industrial chemicals and plant protection products, but also in the monitoring of environmental quality. With few exceptions, such test systems are discontinuous. They require exposure of the biological test material in small units, such as multiwell plates, during prolonged incubation periods, and do not allow online read-outs. It is mostly due to these shortcomings that applications in continuous monitoring of, e...
2017: PloS One
https://www.readbyqxmd.com/read/28595924/mechanisms-of-acaricide-resistance-in-the-cattle-tick-rhipicephalus-boophilus-microplus-in-sri-lanka
#4
K M U Janadaree Bandara, S H P Parakrama Karunaratne
High tolerance of ticks to acaricides is increasingly becoming a problem to cattle farmers. Resistance status of Rhipicephalus (Boophilus) microplus (Acari: Ixodidae)from two cattle farms of Sri Lanka were determined against different concentrations of pyrethroid permethrin, organophosphate malathion, organochlorine DDT and carbamate propoxur using Larval Packet Test (LPT) as recommended by Food and Agriculture Organization (FAO). Mechanisms of acaricide resistance were studied by conducting biochemical and PCR assays...
June 2017: Pesticide Biochemistry and Physiology
https://www.readbyqxmd.com/read/28595653/habitat-productivity-and-pyrethroid-susceptibility-status-of-aedes-aegypti-mosquitoes-in-dar-es-salaam-tanzania
#5
Leah Mathias, Vito Baraka, Anitha Philbert, Ester Innocent, Filbert Francis, Gamba Nkwengulila, Eliningaya J Kweka
BACKGROUND: Aedes aegypti (Diptera: Culicidae) is the main vector of the dengue virus globally. Dengue vector control is mainly based on reducing the vector population through interventions, which target potential breeding sites. However, in Tanzania, little is known about this vector's habitat productivity and insecticide susceptibility status to support evidence-based implementation of control measures. The present study aimed at assessing the productivity and susceptibility status of A...
June 9, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28589271/surveillance-of-pesticide-residues-in-fruits-and-vegetables-from-accra-metropolis-markets-ghana-2010-2012-a-case-study-in-sub-saharan-africa
#6
Paul Osei Fosu, Augustine Donkor, Cephas Ziwu, Brajesh Dubey, Robert Kingsford-Adaboh, Isaac Asante, Stephen Nyarko, Rose Tawiah, Noble Nazzah
Monitoring of pesticide residues in food commodities of plant origin is part of the regular controls on food to safeguard consumer's health. This study reports for the first time in Ghana a 3-year (2010-2012) monitoring of pesticide contamination of fruits and vegetables and their health implications. A total of 3483 samples were purchased in notable markets within Accra Metropolis and analysed for pesticide residues, employing the modified quick, easy, cheap, effective, rugged and safe analytical procedure...
June 6, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28586286/optimization-of-a-methodology-for-the-simultaneous-determination-of-deltamethrin-permethrin-and-malathion-in-stored-wheat-samples-using-dispersive-liquid-liquid-microextraction-with-solidification-of-floating-organic-drop-and-hplc-uv
#7
Meghdad Pirsaheb, Mansour Rezaei, Nazir Fattahi, Mohammad Karami, Kiomars Sharafi, Hamid R Ghaffari
The purpose of this study was to investigate common pesticides in stored wheat at Kermanshah province's silos in Iran. A simple, inexpensive, reliable and environmentally friendly method based on dispersive liquid-liquid microextraction with solidification of floating organic drop was developed. The analytical characteristics of the method were determined. Also, various parameters such as the materials of the silos, types of ownerships of the silos, geographic orientation of silo locations and climatic conditions of silo locations on pesticide residues in studied wheat samples were investigated...
June 6, 2017: Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes
https://www.readbyqxmd.com/read/28583207/knockdown-resistance-kdr-of-the-voltage-gated-sodium-channel-gene-of-aedes-aegypti-population-in-denpasar-bali-indonesia
#8
Penny Humaidah Hamid, Joko Prastowo, Anis Widyasari, Anja Taubert, Carlos Hermosilla
BACKGROUND: Aedes aegypti is the main vector of several arthropod-borne viral infections in the tropics profoundly affecting humans, such as dengue fever (DF), West Nile (WN), chikungunya and more recently Zika. Eradication of Aedes still largely depends on insecticides, which is the most cost-effective strategy, and often inefficient due to resistance development in exposed Aedes populations. We here conducted a study of Ae. aegypti resistance towards several insecticides regularly used in the city of Denpasar, Bali, Indonesia...
June 5, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28577330/treated-wastewater-effluents-as-a-source-of-pyrethroids-and-fipronil-at-todos-santos-bay-mexico-its-impact-on-sediments-and-organisms
#9
Félix Augusto Hernández-Guzmán, José Vinicio Macías-Zamora, Nancy Ramírez-Álvarez, Arturo Alvarez-Aguilar, Cristina Quezada-Hernández, Ana Paula Fonseca
Pyrethroids are insecticides widely used to control pests and disease vectors in residential areas and agricultural lands. As pyrethroids are emerging pollutants, their use is a growing concern due to their toxicity potential on aquatic organisms. Todos Santos Bay and Punta Banda estuary, two coastal bodies located to the south of Southern California Bight, were studied to establish a baseline of the current conditions of pollution by pyrethroids and fipronil. Eight pyrethroids along with fipronil and its two metabolites were determined in effluents from wastewater treatment plants (n = 3), surface sediments (n = 32), and three locations with mussels [Mytilus californianus] (n = 9)...
June 3, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28561292/guideline-for-the-diagnosis-and-treatment-of-scabies-in-japan-third-edition-executive-committee-of-guideline-for-the-diagnosis-and-treatment-of-scabies
#10
(no author information available yet)
In the current work, we present our new guideline for the diagnosis and treatment of scabies which we, the Executive Committee convened by the Japanese Dermatological Association, developed to ensure proper diagnosis and treatment of scabies in Japan. Approval of phenothrin topical use under the National Health Insurance in August 2014 led to this action. Permethrin, a topical anti-scabietic medication belonging to the same pyrethroid group as phenothrin, is already in use worldwide. In this guideline, we introduce criteria for a proper diagnosis of scabies, treatment algorithm for common and crusted (hyperkeratotic) scabies, and prevention...
May 31, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28542335/interventions-that-effectively-target-anopheles-funestus-mosquitoes-could-significantly-improve-control-of-persistent-malaria-transmission-in-south-eastern-tanzania
#11
Emmanuel W Kaindoa, Nancy S Matowo, Halfan S Ngowo, Gustav Mkandawile, Arnold Mmbando, Marcelina Finda, Fredros O Okumu
Malaria is transmitted by many Anopheles species whose proportionate contributions vary across settings. We re-assessed the roles of Anopheles arabiensis and Anopheles funestus, and examined potential benefits of species-specific interventions in an area in south-eastern Tanzania, where malaria transmission persists, four years after mass distribution of long-lasting insecticide-treated nets (LLINs). Monthly mosquito sampling was done in randomly selected households in three villages using CDC light traps and back-pack aspirators, between January-2015 and January-2016, four years after the last mass distribution of LLINs in 2011...
2017: PloS One
https://www.readbyqxmd.com/read/28536878/erratum-to-long-lasting-permethrin-impregnated-clothing-protective-efficacy-against-malaria-in-hyperendemic-foci-and-laundering-wearing-and-weathering-effects-on-residual-bioactivity-after-worst-case-use-in-the-rain-forests-of-french-guiana
#12
Bruno Most, Vincent Pommier de Santi, Frédéric Pagès, Marie Mura, Waltraud M Uedelhoven, Michael K Faulde
No abstract text is available yet for this article.
May 23, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28536439/pesticides-in-fine-airborne-particles-from-a-green-analysis-method-to-atmospheric-characterization-and-risk-assessment
#13
Madson M Nascimento, Gisele O da Rocha, Jailson B de Andrade
The intensive use of pesticides such as herbicides, insecticides, fungicides and acaricides has been lead to ubiquitous contamination, being present not only in soils, water bodies and/or crops, but also in the atmosphere. Considering the massive amount of pesticides employed globally, together to their persistence, this may be an important concern regarding air quality and human health worldwide. In the present study we developed a green sensitive sample preparation method for determination of nine organophosphates, two pyrethroids, one carbamate, and one strobirulin in PM2...
May 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28523490/ivermectin-lipid-based-nanocarriers-as-novel-formulations-against-head-lice
#14
Gabriela Ullio-Gamboa, Santiago Palma, Jean Pierre Benoit, Daniel Allemandi, María Inés Picollo, Ariel Ceferino Toloza
The use of pyrethroids to control the human head louse, Pediculus humanus capitis De Geer (Anoplura: Pediculidae), has suffered considerable loss of efficacy due to the evolution of resistance. Thus, the development of efficiently insecticide delivery systems is imperative for the control of head lice. We studied the insecticidal activity of ivermectin-loaded lipid nanocapsules (IVM-LNC) against permethrin-resistant head lice from Argentina. The LNC, prepared by a phase inversion procedure, were characterized in terms of size, surface potential, and physical stability...
May 18, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28505888/fipronil-washoff-to-municipal-wastewater-from-dogs-treated-with-spot-on-products
#15
Jennifer Teerlink, Jorge Hernandez, Robert Budd
Fipronil and fipronil degradates have been reported in treated wastewater effluent at concentrations that exceed USEPA Aquatic Life Benchmarks, posing a potential risk to the surface waters to which they discharge. Fipronil is a common insecticide found in spot-on flea and tick treatment products that have the potential for down-the-drain transport and direct washoff into surface water. Volunteers currently treating their dogs with a fipronil-containing spot-on product were recruited. Dogs were washed either 2, 7, or 28days after product application, and rinsate from 34 discrete bathing events were analyzed by LC-MS/MS for fipronil and fipronil degradates (collectively known as fiproles)...
December 1, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28495520/brain-uptake-of-deltamethrin-in-rats-as-a-function-of-plasma-protein-binding-and-blood-brain-barrier-maturation
#16
Manoj Amaraneni, Jing Pang, Tanzir B Mortuza, Srinivasa Muralidhara, Brian S Cummings, Catherine A White, Charles V Vorhees, Jason Zastre, James V Bruckner
Pyrethroids, including permethrin and deltamethrin (DLM), are very widely used of insecticides. It was hypothesized that lower plasma binding and increased blood-brain barrier (BBB) penetration of DLM in immature rats contribute to the higher brain concentrations of DLM and more pronounced neurotoxicity reported in this age group. The left brain of anesthetized adult rats was perfused for 2min via a carotid artery with 1μM (14)C-DLM in: 2-5% human serum albumin (HSA); plasma from adult and 15- and 21-d-old rats; and plasma from human donors of: birth-1 week, 1-4 weeks, 4 weeks-1 year, 1-3 years and adults...
May 8, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28493716/bifenthrin-causes-toxicity-in-urban-stormwater-wetlands-field-and-laboratory-assessment-using-austrochiltonia-amphipoda
#17
Katherine J Jeppe, Claudette R Kellar, Stephen Marshall, Valentina Colombo, Georgia M Sinclair, Vincent Pettigrove
Stormwater wetlands are engineered to accumulate sediment and pollutants from stormwater and provide environmental value to urban environments. Therefore, contaminated sediment risks causing toxicity to aquatic fauna. This research identifies contaminants of concern in urban wetland sediments by assessing sediment toxicity using the amphipod Austrochiltonia subtenuis. Sediments from 98 wetlands were analyzed for contaminants, and laboratory bioassays were performed with A. subtenuis. Wild Austrochiltonia spp...
May 30, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28472570/scabies-a-clinical-update
#18
Myra Hardy, Daniel Engelman, Andrew Steer
BACKGROUND: Scabies is a common, yet neglected, skin disease. Scabies occurs across Australia, but most frequently in socioeconomically disadvantaged populations in tropical regions, including in remote Aboriginal and Torres Strait Islander communities. In temperate settings, the disease clusters in institutional care facilities. OBJECTIVE: The objective of this article is to provide updates on the clinical diagnosis and treatment approaches for scabies in Australia...
2017: Australian Family Physician
https://www.readbyqxmd.com/read/28469858/case-report-a-new-method-for-treatment-of-permethrin-resistant-head-lice
#19
Farhad Jahangiri
Head lice (Pediculus humanus capitis) infestation is an important disease worldwide, especially in children under 11 years old. Permethrin is the most common insecticide for treatment of human pediculosis, but nowadays resistance to permethrin and other pyrethroids has caused many treatment failures. The second treatment of choice is malathion.
May 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28456543/subchronic-toxicity-of-low-dose-propoxur-permethrin-and-their-combination-on-the-redox-status-of-rat-liver
#20
Pan Wang, Ming-Yuan Xu, Yu-Jie Liang, Hui-Ping Wang, Ying-Jian Sun, Ding-Xin Long, Yi-Jun Wu
Carbamates and pyrethroids are widely used pesticides. However, their joint toxicity at low doses with long-term exposure remains unknown. Therefore, we investigated the subchronic joint hepatotoxicity of the two representative pesticides within these two classes, i.e., propoxur (PR) and permethrin (PE) in rats. The male Wistar rats were orally treated with three different doses of PR, PE and their mixtures for 90 consecutive days. Liver weight, serum clinical chemistry parameters and histopathological changes were measured to access the hepatotoxicity...
June 25, 2017: Chemico-biological Interactions
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