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https://www.readbyqxmd.com/read/29784773/associated-patterns-of-insecticide-resistance-in-field-populations-of-malaria-vectors-across-africa
#1
Penelope A Hancock, Antoinette Wiebe, Katherine A Gleave, Samir Bhatt, Ewan Cameron, Anna Trett, David Weetman, David L Smith, Janet Hemingway, Michael Coleman, Peter W Gething, Catherine L Moyes
The development of insecticide resistance in African malaria vectors threatens the continued efficacy of important vector control methods that rely on a limited set of insecticides. To understand the operational significance of resistance we require quantitative information about levels of resistance in field populations to the suite of vector control insecticides. Estimation of resistance is complicated by the sparsity of observations in field populations, variation in resistance over time and space at local and regional scales, and cross-resistance between different insecticide types...
May 21, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29780007/hidradenitis-suppurativa-metabolic-syndrome-and-demodex-spp-infestation
#2
Emine Ünal, Ulviye Güvendi Akçınar, Ayşe Arduç
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease. This type of dermatosis with underlying chronic inflammation significantly affects the quality of life and may be accompanied by many comorbidities. In this case, Demodex spp. was associated with treatment-resistant and persistent course of skin diseases. A 46-year-old female patient applied to our clinic with complaints of lesions on the body and hip. Her dermatological examination revealed abscess formation and post-inflammatory pigmentation...
May 21, 2018: Türkiye Parazitolojii Dergisi
https://www.readbyqxmd.com/read/29779827/zika-virus-report-from-the-task-force-on-tropical-diseases-by-the-world-federation-of-societies-of-intensive-and-critical-care-medicine
#3
Gisele Sampaio Silva, Guy A Richards, Tim Baker, Jorge Hidalgo, Juan Ignacio Silesky Jiménez, Pravin Amin
Zika fever is an acute infectious disease caused by the Zika virus (ZIKV), an RNA virus belonging to the genus Flavivirus. ZIKV can be transmitted by bites from Aedes aegypti and Aedes albopictus species, sexual activity, blood transfusion and from mother to fetus during pregnancy and delivery. A total of 50 territories and countries in the Americas had reported ZIKV infections. For those with symptoms, the presentation is similar to dengue fever with body aches, joint pain, fatigue, malaise, fever and conjunctivitis lasting up to seven days...
April 5, 2018: Journal of Critical Care
https://www.readbyqxmd.com/read/29779438/metabolism-of-deltamethrin-and-cis-and-trans-permethrin-by-human-expressed-cytochrome-p450-and-carboxylesterase-enzymes
#4
Laura Hedges, Susan Brown, A Kenneth MacLeod, Audrey Vardy, Edward Doyle, Gina Song, Marjory Moreau, Miyoung Yoon, Thomas G Osimitz, Brian G Lake
1. The metabolism of the pyrethroids deltamethrin (DLM), cis-permethrin (CPM) and trans-permethrin (TPM) was studied in human expressed cytochrome P450 (CYP) and carboxylesterase (CES) enzymes. 2. DLM, CPM and TPM were metabolised by human CYP2B6 and CYP2C19, with the highest apparent intrinsic clearance (CLint ) values for pyrethroid metabolism being observed with CYP2C19. Other CYP enzymes contributing to the metabolism of one or more of the three pyrethroids were CYP1A2, CYP2C8, CYP2C9*1, CYP2D6*1, CYP3A4 and CYP3A5...
May 21, 2018: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/29779193/functional-role-of-tyr12-in-the-catalytic-activity-of-novel-zeta-like-glutathione-s-transferase-from-acidovorax-sp-kks102
#5
Dayyabu Shehu, Zazali Alias
Glutathione S-transferases (GSTs) are a family of enzymes that function in the detoxification of variety of electrophilic substrates. In the present work, we report a novel zeta-like GST (designated as KKSG9) from the biphenyl/polychlorobiphenyl degrading organism Acidovorax sp. KKS102. KKSG9 possessed low sequence similarity but similar biochemical properties to zeta class GSTs. Functional analysis showed that the enzyme exhibits wider substrate specificity compared to most zeta class GSTs by reacting with 1-chloro-2,4-dinitrobenzene (CDNB), p-nitrobenzyl chloride (NBC), ethacrynic acid (EA), hydrogen peroxide, and cumene hydroperoxide...
May 19, 2018: Protein Journal
https://www.readbyqxmd.com/read/29771941/efficacy-of-ivermectin-mass-drug-administration-to-control-scabies-in-asylum-seekers-in-the-netherlands-a-retrospective-cohort-study-between-january-2014-march-2016
#6
Dorien T Beeres, Sofanne J Ravensbergen, Annelies Heidema, Darren Cornish, Machiel Vonk, Leonie D Wijnholds, Jessica J H Hendriks, Johanneke Kleinnijenhuis, Till F Omansen, Ymkje Stienstra
Scabies is a skin infestation with the mite Sarcoptes scabiei causing itch and rash and is a major risk factor for bacterial skin infections and severe complications. Here, we evaluated the treatment outcome of 2866 asylum seekers who received (preventive) scabies treatment before and during a scabies intervention programme (SIP) in the main reception centre in the Netherlands between January 2014 and March 2016. A SIP was introduced in the main national reception centre based on frequent observations of scabies and its complications amongst Eritrean and Ethiopian asylum seekers in the Netherlands...
May 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29763445/pyrethroid-insecticides-maintain-repellent-effect-on-knock-down-resistant-populations-of-aedes-aegypti-mosquitoes
#7
Natalie M Bowman, Kristin Akialis, Grayson Cave, Roberto Barrera, Charles S Apperson, Steven R Meshnick
Pyrethroid-treated clothing is commonly worn for protection against mosquitoes; pyrethroids are both insecticides and repellents. Pyrethroid resistance has become increasingly common in Aedes aegypti, the vector of dengue, Zika, and other arboviruses, but it is not clear whether resistance is associated with reductions in repellency. In order to determine whether long-lasting permethrin impregnated (LLPI) clothing is protective, we used Aedes aegypti from New Orleans, LA (pyrethroid-sensitive) and San Juan, PR (resistant) to measure both lethality and repellency...
2018: PloS One
https://www.readbyqxmd.com/read/29758171/aedes-aegypti-linnaeus-larvae-from-dengue-outbreak-areas-in-selangor-showing-resistance-to-pyrethroids-but-susceptible-to-organophosphates
#8
Cherng Shii Leong, Indra Vythilingam, Meng Li Wong, Wan-Yusoff Wan Sulaiman, Yee Ling Lau
The resistance status of Selangor Aedes aegypti (Linnaeus) larvae against four major groups of insecticides (i.e., organochlorines, carbamates, organophosphates and pyrethroids) was investigated. Aedes aegypti were susceptible against temephos (organophosphate), although resistance (RR50  = 0.21 - 2.64) may be developing. The insecticides susceptibility status of Ae. aegypti larvae were found heterogeneous among the different study sites. Results showed that Ae. aegypti larvae from Klang, Sabak Bernam and Sepang were susceptible against all insecticides tested...
May 11, 2018: Acta Tropica
https://www.readbyqxmd.com/read/29753004/aggregate-exposure-of-the-adult-french-population-to-pyrethroids
#9
Keyvin Darney, Laurent Bodin, Michèle Bouchard, Jonathan Côté, Jean-Luc Volatier, Virginie Desvignes
The French Nutrition and Health Survey (ENNS) reported higher biomarker levels of exposure to pyrethroids than those observed in North American and German biomonitoring studies. The authors therefore investigated aggregate exposure to permethrin as an initial case study because this compound is one of the most widely-used pyrethroid insecticides. We assessed several contamination sources-such as indoor and outdoor air, settled dust and diet-and several pathways, including oral, inhalation and dermal routes...
May 9, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29751049/increased-butyrate-priming-in-the-gut-stalls-microbiome-associated-gastrointestinal-inflammation-and-hepatic-metabolic-reprogramming-in-a-mouse-model-of-gulf-war-illness
#10
Ratanesh Kumar Seth, Diana Kimono, Firas Alhasson, Sutapa Sarkar, Muayad Albadrani, Stephen K Lasley, Ronnie Horner, Patricia Janulecewicz, Mitzi Nagarkatti, Prakash Nagarkatti, Kimberly Sullivan, Saurabh Chatterjee
Most of the associated pathologies in Gulf War Illness (GWI) have been ascribed to chemical and pharmaceutical exposures during the war. Since an increased number of veterans complain of gastrointestinal (GI), neuroinflammatory and metabolic complications as they age and there are limited options for a cure, the present study was focused to assess the role of butyrate, a short chain fatty acid for attenuating GWI-associated GI and metabolic complications. Results in a GWI-mouse model of permethrin and pyridostigmine bromide (PB) exposure showed that oral butyrate restored gut homeostasis and increased GPR109A receptor copies in the small intestine (SI)...
May 8, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29741206/low-concentrations-of-permethrin-and-malathion-induce-numerical-and-structural-abnormalities-in-kmt2a-and-igh-genes-in-vitro
#11
M P Navarrete-Meneses, A I Pedraza-Meléndez, C Salas-Labadía, D Moreno-Lorenzana, P Pérez-Vera
Pesticides are commonly used worldwide and almost every human is potentially exposed to these chemicals. Exposure to pesticides such as permethrin and malathion has been associated with hematological malignancies in epidemiological studies. However, biological evidence showing if these chemicals induce genetic aberrations involved in the etiology of leukemia and lymphoma is missing. In our previous work, we have shown that a single high exposure (200 μm, 24 hours) of permethrin and malathion induce damage in genes associated with hematological malignancies in peripheral blood mononuclear cells analyzed by interphase fluorescence in situ hybridization (FISH)...
May 9, 2018: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/29728155/malaria-infection-in-mosquitoes-decreases-the-personal-protection-offered-by-permethrin-treated-bednets
#12
Kevin Thiévent, Lorenz Hofer, Elise Rapp, Mgeni Mohamed Tambwe, Sarah Moore, Jacob C Koella
BACKGROUND: Insecticides targeting adult mosquitoes are the main way of controlling malaria. They work not only by killing mosquitoes, but also by repelling and irritating them. Indeed their repellent action gives valuable personal protection against biting mosquitoes. In the context of malaria control this personal protection is especially relevant when mosquitoes are infectious, whereas to protect the community we would prefer that the mosquitoes that are not yet infectious are killed (so, not repelled) by the insecticide...
May 4, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29724237/larval-density-mediates-knockdown-resistance-to-pyrethroid-insecticides-in-adult-aedes-aegypti
#13
Marissa K Grossman, Valentin Uc-Puc, Adriana E Flores, Pablo C Manrique-Saide, Gonzalo M Vazquez-Prokopec
BACKGROUND: Understanding mechanisms driving insecticide resistance in vector populations remains a public health priority. To date, most research has focused on the genetic mechanisms underpinning resistance, yet it is unclear what role environmental drivers may play in shaping phenotypic expression. One of the key environmental drivers of Aedes aegypti mosquito population dynamics is resource-driven intraspecific competition at the larval stage. We experimentally investigated the role of density-dependent larval competition in mediating resistance evolution in Ae...
May 3, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29718490/patterns-of-tarnished-plant-bug-hemiptera-miridae-resistance-to-pyrethroid-insecticides-in-the-lower-mississippi-delta-for-2008-2015-linkage-to-pyrethroid-use-and-cotton-insect-management
#14
Katherine A Parys, Randall G Luttrell, Gordon L Snodgrass, Maribel R Portilla
Populations of tarnished plant bug, Lygus lineolaris (Palisot de Beauvois) (Hemiptera: Miridae), from the Lower Mississippi Delta regions of Arkansas, Louisiana, and Mississippi were evaluated from 2008 through 2015 for susceptibility to pyrethroid insecticides using a diagnostic-dose assay with permethrin. Resulting data add to the compilation of pyrethroid susceptibility data carefully tracked in this pest since 1994 and provide continuing evidence of high frequencies of pyrethroid resistance in field populations of the tarnished plant bug...
March 1, 2018: Journal of Insect Science
https://www.readbyqxmd.com/read/29707654/first-report-of-the-presence-of-l1014s-knockdown-resistance-mutation-in-anopheles-gambiae-s-s-and-anopheles-coluzzii-from-togo-west-africa
#15
Innocent Djègbè, Romaric Akoton, Genevieve Tchigossou, Koffi Mensah Ahadji-Dabla, Seun Michael Atoyebi, Razack Adéoti, Francis Zeukeng, Guillaume Koffivi Ketoh, Rousseau Djouaka
Background: To optimize the success of insecticide-based malaria control intervention, knowledge of the distribution of Anopheles gambiae species and insecticide resistance mechanisms is necessary. This paper reported an updated data on pyrethroids/DDT resistance in the An. gambiae s.l population from Togo.  Methods: From December 2013 to April 2015, females of indoor-resting An. gambiae s.l were captured in three locations belonging to three different ecological zones. Resistance to DDT, permethrin and deltamethrin was screened in F1 progeny of collected mosquitoes using WHO susceptibility tests...
2018: Wellcome Open Research
https://www.readbyqxmd.com/read/29707002/determination-of-pyrethroids-in-tea-brew-by-gc-ms-combined-with-spme-with-multiwalled-carbon-nanotube-coated-fiber
#16
Dongxia Ren, Chengjun Sun, Guanqun Ma, Danni Yang, Chen Zhou, Jiayu Xie, Yongxin Li
A new method has been developed to simultaneously determine 7 pyrethroid residues in tea brew using gas chromatography-mass spectrometry (GC-MS) combined with solid phase microextraction (SPME) with multiwalled carbon nanotubes (MWCNTs) coated fiber. The MWCNTs coated fiber of SPME was homemade by using stainless steel wire as coating carrier and polyacrylonitrile (PAN) solution as adhesive glue. Under the optimized conditions, a good linearity was shown for bifenthrin, fenpropathrin, permethrin, and cyfluthrin in 1-50 ng mL-1 and for cypermethrin, fenvalerate, and deltamethrin in 5-50 ng mL-1 ...
2018: International Journal of Analytical Chemistry
https://www.readbyqxmd.com/read/29693596/measurement-of-pesticide-residues-from-chemical-control-of-the-invasive-spodoptera-frugiperda-lepidoptera-noctuidae-in-a-maize-experimental-field-in-mokwa-nigeria
#17
Abou Togola, Silvestro Meseka, Abebe Menkir, Baffour Badu-Apraku, Ousmane Boukar, Manuele Tamò, Rousseau Djouaka
The management of the fall armyworm Spodoptera frugiperda in maize field necessitates the use a big quantities of insecticides and sometimes the use of multiple types and formulations of chemicals. The use of insecticides in crops is associated with environmental risks and health hazards to both producers and consumers. This study was designed to evaluate the residue of 11 insecticides that were used to control high population of the fall armyworm in maize field in Mokwa, Nigeria. Maize and soil samples were collected from an experimental field to investigate the residue level using high performance liquid chromatography (HPLC, Agilent Technologies, Santa Clara, CA, USA) analysis techniques...
April 25, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29687728/exposure-to-permethrin-and-cancer-risk-a-systematic-review
#18
Paolo Boffetta, Vimi Desai
No systematic reviews are available on data from humans on cancer risk from exposure to permethrin, a widely used insecticide for which some animal studies have reported positive findings based on mechanisms that may not be relevant to humans. We identified potentially relevant articles through a search of electronic databases which included all studies of pesticide exposure and human cancer. A total of 18 articles were selected, including six identified from the list of references of other articles. Most articles were based on analyzes of the Agriculture Health Study (AHS); they provided no evidence of an increased risk of cancers of colon, rectum, pancreas, lung, melanoma, female breast, prostate, urinary bladder, as well as non-Hodgkin lymphoma (including its main subtypes), and leukemia...
April 24, 2018: Critical Reviews in Toxicology
https://www.readbyqxmd.com/read/29670071/susceptibility-status-and-resistance-mechanisms-in-permethrin-selected-laboratory-susceptible-and-field-collected-aedes-aegypti-from-malaysia
#19
Rosilawati Rasli, Han Lim Lee, Nazni Wasi Ahmad, Siti Futri Farahininajua Fikri, Roziah Ali, Khairul Asuad Muhamed, Azahari Abdul Hadi, Qi-Yong Liu, Feng Xia Meng
This study is intended to provide a comprehensive characterization of the resistance mechanisms in the permethrin-selected (IMR-PSS) and laboratory susceptible (IMR-LS) Aedes aegypti strain from Malaysia. Both IMR-PSS and IMR-LS provide a standard model for use in assessing the pyrethroid resistance in field-collected strains collected from three dengue hotspots: the Taman Seri Bayu (TSB), the Flat Camar (FC), and the Taman Dahlia (TD). Two established methods for determining the resistance mechanisms of the pyrethroid are the quantification of detoxification enzymes via enzyme microassay and the nucleotide sequencing of the domain 2 region from segment 1 to 6 via classical polymerase chain reaction (PCR) amplification-were employed...
April 18, 2018: Insects
https://www.readbyqxmd.com/read/29661207/repellent-efficacy-of-a-new-combination-of-fipronil-and-permethrin-against-lutzomyia-longipalpis
#20
André Antonio Cutolo, Fredy Galvis-Ovallos, Elisangela de Souza Neves, Fabiano O Silva, S Theodore Chester, Becky Fankhauser
BACKGROUND: Lutzomyia longipalpis is the main vector of Leishmania infantum, the agent of canine and human visceral leishmaniosis in the Americas. Considering that the dog is the main domestic host of the parasite, repellent treatment is a measure that might contribute to the prevention of canine visceral leishmaniosis. The repellent efficacy of a single treatment of a new spot-on topical combination of fipronil and permethrin (Frontline Tri-Act®, Merial, now part of Boehringer-Ingelheim) to repel Lu...
April 16, 2018: Parasites & Vectors
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