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https://www.readbyqxmd.com/read/28453973/determinants-of-children-s-exposure-to-pyrethroid-insecticides-in-western-france
#1
Philippe Glorennec, Tania Serrano, Morgane Fravallo, Charline Warembourg, Christine Monfort, Sylvaine Cordier, Jean-François Viel, Florent Le Gléau, Barbara Le Bot, Cécile Chevrier
Pyrethroids are insecticides frequently used in agriculture and in the home; exposure occurs through dietary and non-dietary pathways, including indoor and outdoor environmental contamination. Our objective was to study the potential determinants of pyrethroid metabolite concentrations measured in children's urine samples and in the dust of their homes. Specifically, we measured urinary metabolites from morning spot samples of 245 six-year-old children living in Brittany (France) in 2009-2012 and from dust vacuumed from the floor of their homes...
April 25, 2017: Environment International
https://www.readbyqxmd.com/read/28453542/phospholipid-profiling-of-plasma-from-gw-veterans-and-rodent-models-to-identify-potential-biomarkers-of-gulf-war-illness
#2
Tanja Emmerich, Zuchra Zakirova, Nancy Klimas, Kimberly Sullivan, Ashok K Shetty, James E Evans, Ghania Ait-Ghezala, Gary S Laco, Bharathi Hattiangady, Geetha A Shetty, Michael Mullan, Gogce Crynen, Laila Abdullah, Fiona Crawford
Gulf War Illness (GWI), which affects at least one fourth of the 700,000 veterans deployed to the Gulf War (GW), is characterized by persistent and heterogeneous symptoms, including pain, fatigue and cognitive problems. As a consequence, this illness remains difficult to diagnose. Rodent models have been shown to exhibit different symptomatic features of GWI following exposure to particular GW agents (e.g. pyridostigmine bromide, permethrin and DEET) and/or stress. Preclinical analyses have shown the activation of microglia and astroglia as a pathological hallmark in these mouse and rat models...
2017: PloS One
https://www.readbyqxmd.com/read/28445697/influence-of-maturation-on-in-vivo-tissue-to-plasma-partition-coefficients-for-cis-and-trans-permethrin
#3
Manoj Amaraneni, Jing Pang, James V Bruckner, Srinivasa Muralidhara, Tanzir B Mortuza, Darren Gullick, Shirin Hooshfar, Catherine A White, Brian S Cummings
Permethrin, the most widely used household insecticide in the U.S., is marketed as a mixture of its cis (CIS) and trans (TRANS) isomers. The major objective of this investigation was to develop and utilize a reliable approach to determine in vivo partition coefficients (PCs) for CIS and TRANS in immature and adult Sprague-Dawley rats. Adult, postnatal day (PND) 21 and PND 15 rats were infused with environmentally relevant concentrations of CIS or TRANS via a s.c. osmotic pump for 48 or 72 h. The adult and PND 21 rats also received an oral loading dose...
April 23, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28437449/insecticide-resistance-status-of-malaria-vectors-in-lao-pdr
#4
Sébastien Marcombe, Julie Bobichon, Boutsady Somphong, Nothasin Phommavan, Santi Maithaviphet, Simone Nambanya, Vincent Corbel, Paul T Brey
Knowledge on insecticide resistance in Anopheles species is a basic requirement to guide malaria vector control programs. In Lao PDR, vector control relies on insecticide residual spraying (IRS) and impregnated bed-nets (ITNs) with the use of pyrethroids. Here, the susceptibility of Anopheles species, including several malaria vectors (An. maculatus and An. minimus), to various insecticides was investigated in ten provinces of Lao PDR through a north-south transect. Bioassays were performed on field caught female mosquitoes using the standard WHO susceptibility tests with DDT (4%), deltamethrin (0...
2017: PloS One
https://www.readbyqxmd.com/read/28431163/an-evaluation-of-the-human-relevance-of-the-lung-tumors-observed-in-female-mice-treated-with-permethrin-based-on-mode-of-action
#5
Tomoya Yamada, Miwa Kondo, Kaori Miyata, Keiko Ogata, Masahiko Kushida, Kayo Sumida, Satoshi Kawamura, Thomas G Osimitz, Brian G Lake, Samuel M Cohen
Permethrin increased the incidence of bronchiolo-alveolar adenomas in female mice but not male mice or female or male rats. Studies were conducted to determine whether permethrin has mitogenic activity in Club cells in mouse lung as the basis for the mode of action (MOA) for the lung adenoma induction. Several short term experiments focusing on time-course, dose-response, reversibility, sex difference, strain difference, and species difference were evaluated for Club cell proliferation and morphology. The findings demonstrated that permethrin slightly and continuously enhanced Club cell proliferation at tumor-associated dose levels in female mice, but did not increase proliferation in male mice or in female rats...
April 18, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28428243/genome-wide-transcription-and-functional-analyses-reveal-heterogeneous-molecular-mechanisms-driving-pyrethroids-resistance-in-the-major-malaria-vector-anopheles-funestus-across-africa
#6
Jacob M Riveron, Sulaiman S Ibrahim, Charles Mulamba, Rousseau Djouaka, Helen Irving, Murielle J Wondji, Intan H Ishak, Charles S Wondji
Pyrethroid resistance in malaria vector, An. Funestus is increasingly reported across Africa, threatening the sustainability of pyrethroid-based control interventions including long lasting insecticidal Nets (LLINs). Managing this problem requires understanding of the molecular basis of the resistance from different regions of the continent, to establish whether it is being driven by a single or independent selective events. Here, using a genome-wide transcription profiling of pyrethroid resistant populations from Southern (Malawi), East (Uganda) and West Africa (Benin), we investigated the molecular basis of resistance, revealing strong differences between the different African regions...
April 19, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/28427447/benchmarking-insecticide-resistance-intensity-bioassays-for-anopheles-malaria-vector-species-against-resistance-phenotypes-of-known-epidemiological-significance
#7
Nelius Venter, Shȕné V Oliver, Mbanga Muleba, Craig Davies, Richard H Hunt, Lizette L Koekemoer, Maureen Coetzee, Basil D Brooke
BACKGROUND: Insecticide use via indoor residual spraying (IRS) or treated nets is the primary method for controlling malaria vector populations. The incidence of insecticide resistance in vector populations is burgeoning globally making resistance management key to the design of effective malaria control and elimination strategies. Vector populations can be assessed for insecticide resistance using a binary (susceptible or resistant) classification based on the use of the standard WHO insecticide susceptibility assay for adult anopheline mosquitoes...
April 20, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28424101/limited-impacts-of-truck-based-ultra-low-volume-applications-of-mosquito-adulticides-on-mortality-in-honey-bees-apis-mellifera
#8
F D Rinkevich, J W Margotta, V Pokhrel, T W Walker, R H Vaeth, W C Hoffman, B K Fritz, R G Danka, T E Rinderer, R L Aldridge, K J Linthicum, J A Ottea, K B Healy
Adulticides applied against mosquitoes can reduce vector populations during times of high arbovirus transmission. However, impacts of these insecticides on pollinators and other non-target organisms are of concern to mosquito control professionals, beekeepers and others. We evaluated mortality of Culex quinquefasciatus and Apis mellifera when caged insects were exposed to low and high label rates of four common adulticides (Aqua-Pursuit™ [permethrin], Duet® [prallethrin + sumithrin], Fyfanon® [malathion] and Scourge® [resmethrin]) at six distances up to 91...
April 20, 2017: Bulletin of Entomological Research
https://www.readbyqxmd.com/read/28421653/permethrin-and-malathion-ld90-values-for-culex-quinquefasciatus-vary-with-topical-application-site
#9
R L Aldridge, P E Kaufman, J R Bloomquist, S A Gezan, K J Linthicum
Prior research in multiple insect species has demonstrated that insecticide-induced mortality varies according to the body region exposed on the insect. This variation has been demonstrated in Culex quinquefasciatus Say (Diptera: Culicidae), but has not been quantified using dose-response curves. Applications of technical permethrin or malathion to one of three body regions on Cx. quinquefasciatus resulted in dose-response curves that were not equivalent to one another. The generated LD90 values and curves for each body region were compared with previously reported LD values for analogous sites in several mosquito species, specifically the mesothorax...
April 19, 2017: Medical and Veterinary Entomology
https://www.readbyqxmd.com/read/28408046/-evaluation-of-practices-in-the-management-of-scabies-in-children
#10
M-S Lê, M-A Richard, K Baumstarck, S Hesse, C Gaudy-Marqueste, J-J Grob, S Mallet
BACKGROUND: Scabies has been on the rise in France in recent years and has posed therapeutic problems, mainly due to the withdrawal of benzyl benzoate. The objective of this study was to describe prescribing practices for scabies in children. METHODS: A national survey was conducted by means of a standardized questionnaire covering various clinical situations of scabies and the drugs used preferentially according to age, which was sent out between December 2014 and March 2015 to members of the clinical research group of the French Society of Paediatric Dermatology...
April 10, 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/28399311/molecular-markers-of-pesticide-resistance-and-pathogens-in-human-head-lice-phthiraptera-pediculidae-from-rural-georgia-usa
#11
Marina E Eremeeva, Danielle Capps, Emmanuel B Winful, Shamta S Warang, Sarah E Braswell, Nikolay K Tokarevich, Denise L Bonilla, Lance A Durden
Although the head louse, Pediculus humanus capitis De Geer, and body louse, Pediculus humanus humanus L., both have a worldwide distribution, the occurrence of head louse pediculosis appears to be more prevalent in modern societies despite systematic use of various pediculicides. This study tested head lice collected in rural Georgia and body lice collected in Russia for the prevalence of a kdr-biomarker that is associated with permethrin resistance. This study also screened lice for the presence of DNA from Bartonella quintana and Acinetobacter species...
March 2, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/28399272/baseline-insecticide-susceptibility-screening-against-six-active-ingredients-for-culex-and-aedes-diptera-culicidae-mosquitoes-in-the-united-states
#12
Stephanie L Richards, Jo Anne G Balanay, Melinda Fields, Kurt Vandock
Mosquitoes may develop resistance to insecticide active ingredients (AI). Thus, mosquitoes should be tested for resistance to confirm efficacy of insecticide-based control, inform management decisions, and protect public and environmental health. Our objectives were to determine a baseline of resistance for six AIs used in mosquito control in the United States to assess how resistance differs between mosquito collection location, AI, and mosquito species (container-ovipositing Aedes and Culex that may oviposit in containers or other sources)...
March 9, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/28398415/misdiagnosed-crusted-scabies-in-an-aids-patient-leads-to-hyperinfestation
#13
Niloofar Yari, C Helen Malone, Antonio Rivas
Crusted scabies is a severe, highly contagious form of classic scabies caused by the mite Sarcoptes scabiei var hominis. Crusted scabies is more common in immunosuppressed populations and overcrowded environments. In this condition, the host's immune system is overwhelmed and unable to defend against the mites on the skin, resulting in hyperinfestation of the host. Diagnosis can be challenging because the condition resembles other common skin conditions, such as plaque psoriasis. Furthermore, delayed diagnosis and inappropriate treatment can lead to worsening of the condition...
March 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/28388328/efficacy-of-deltagard-%C3%A2-fyfanon-%C3%A2-and-evoluer%C3%A2-31-66-against-culex-quinquefasciatus-in-harris-county-texas
#14
James A Dennett, Pamela M Stark, Chris L Fredregill, Mustapha Debboun
The comparative efficacy of ultra-low volume applications of deltamethrin, permethrin, and malathion against specific adult populations of Culex quinquefasciatus , a primary regional vector of Saint Louis encephalitis and West Nile virus, using field cage tests is described. At labeled application rates, the estimated mass median diameters for Fyfanon(®), Evoluer™, and DeltaGard(®) were 18.32, 19.24, and 17.44 μm, respectively. No significant differences (P ≥ 0.01) in mean percent control were observed across all 3 wild populations and a susceptible Sebring strain tested with Fyfanon, DeltaGard, and Evoluer, providing 98...
March 2017: Journal of the American Mosquito Control Association
https://www.readbyqxmd.com/read/28388320/entomological-investigations-during-early-stages-of-a-chikungunya-outbreak-in-the-united-states-virgin-islands-2014
#15
Joan L Kenney, Kristen L Burkhalter, Mariah L Scott, Janet McAllister, Francine E Lang, Stevie Webster, Dwayne J Maduro, Juanita Johannes, Alistair Liburd, John-Paul Mutebi
During the 2014 chikungunya (CHIK) outbreak in the Caribbean, we performed entomological surveys on 3 United States Virgin Islands (USVI): St. Croix, St. Thomas, and St. John. We aimed to evaluate the potential for chikungunya virus (CHIKV) transmission in the USVI. The surveys took place between June 19, 2014, and June 29, 2014, during the dry season in USVI. A total of 1,929 adult mosquitoes belonging to 4 species- Culex quinquefasciatus (68.4%), Aedes aegypti (29.7%), Ae. mediovittatus (1.3%), and Ae. sollicitans (<1%)-were detected...
March 2017: Journal of the American Mosquito Control Association
https://www.readbyqxmd.com/read/28385489/developmental-neurotoxicity-of-different-pesticides-in-pc-12-cells-in-vitro
#16
Verena Christen, Manuel Rusconi, Pierre Crettaz, Karl Fent
The detection of developmental neurotoxicity (DNT) of chemicals has high relevance for protection of human health. However, DNT of many pesticides is only little known. Furthermore, validated in vitro systems for assessment of DNT are not well established. Here we employed the rat phaeochromocytoma cell line PC-12 to evaluate DNT of 18 frequently used pesticides of different classes, including neonicotinoids, pyrethroids, organophosphates, organochlorines, as well as quaternary ammonium compounds, the organic compound used in pesticides, piperonyl butoxide, as well as the insect repellent diethyltoluamide (DEET)...
April 3, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28373679/the-function-of-two-p450s-cyp9m10-and-cyp6aa7-in-the-permethrin-resistance-of-culex-quinquefasciatus
#17
Youhui Gong, Ting Li, Yucheng Feng, Nannan Liu
Cytochrome P450 monooxygenases play a critical role in insecticide resistance by allowing resistant insects to metabolize insecticides. Previous studies revealed that two P450 genes, CYP9M10 and CYP6AA7, are not only up-regulated but also induced in resistant Culex mosquitoes. In this study, CYP9M10 and CYP6AA7 were separately co-expressed with cytochrome P450 reductase (CPR) in insect Spodoptera frugiperda (Sf9) cells using a baculovirus-mediated expression system and the enzymatic activity and metabolic ability of CYP9M10/CPR and CYP6AA7/CPR to permethrin and its metabolites, including 3-phenoxybenzoic alcohol (PBOH) and 3-phenoxybenzaldehyde (PBCHO), characterized...
April 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28371386/complementary-proteomic-approaches-reveal-mitochondrial-dysfunction-immune-and-inflammatory-dysregulation-in-a-mouse-model-of-gulf-war-illness
#18
Zuchra Zakirova, Jon Reed, Gogce Crynen, Lauren Horne, Samira Hassan, Venkatarajan Mathura, Michael Mullan, Fiona Crawford, Ghania Ait-Ghezala
PURPOSE: Long term consequences of combined pyridostigmine bromide and permethrin exposure in C57BL6/J mice using a well characterized mouse model of exposure to these Gulf War (GW) agents were explored at the protein level. EXPERIMENTAL DESIGN: We used orthogonal proteomic approaches to identify pathways that are chronically impacted in the mouse CNS due to semi-acute GW agent exposure early in life. These analyses were performed on soluble and membrane-bound protein fractions from brain samples using two orthogonal isotopic labeling LC-MS/MS proteomic approaches - stable isotope dimethyl labeling and isobaric tags for relative and absolute quantitation...
March 28, 2017: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/28359289/insecticide-resistance-in-malaria-vectors-along-the-thailand-myanmar-border
#19
Victor Chaumeau, Dominique Cerqueira, John Zadrozny, Praphan Kittiphanakun, Chiara Andolina, Theeraphap Chareonviriyaphap, François Nosten, Vincent Corbel
BACKGROUND: There is a paucity of data about the susceptibility status of malaria vectors to Public Health insecticides along the Thailand-Myanmar border. This lack of data is a limitation to guide malaria vector-control in this region. The aim of this study was to assess the susceptibility status of malaria vectors to deltamethrin, permethrin and DDT and to validate a simple molecular assay for the detection of knock-down resistance (kdr) mutations in the study area. METHODS: Anopheles mosquitoes were collected in four sentinel villages during August and November 2014 and July 2015 using human landing catch and cow bait collection methods...
March 31, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28347352/combined-target-site-kdr-mutations-play-a-primary-role-in-highly-pyrethroid-resistant-phenotypes-of-aedes-aegypti-from-saudi-arabia
#20
Ashwaq M Al Nazawi, Jabir Aqili, Mohammed Alzahrani, Philip J McCall, David Weetman
BACKGROUND: Pyrethroid resistance is a threat to effective vector control of Aedes aegypti, the vector of dengue, Zika and other arboviruses, but there are many major knowledge gaps on the mechanisms of resistance. In Jeddah and Makkah, the principal dengue-endemic areas of Saudi Arabia, pyrethroids are used widely for Ae. aegypti control but information about resistance remains sparse, and the underlying genetic basis is unknown. Findings from an ongoing study in this internationally significant area are reported here...
March 27, 2017: Parasites & Vectors
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