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https://www.readbyqxmd.com/read/28542335/interventions-that-effectively-target-anopheles-funestus-mosquitoes-could-significantly-improve-control-of-persistent-malaria-transmission-in-south-eastern-tanzania
#1
Emmanuel W Kaindoa, Nancy S Matowo, Halfan S Ngowo, Gustav Mkandawile, Arnold Mmbando, Marcelina Finda, Fredros O Okumu
Malaria is transmitted by many Anopheles species whose proportionate contributions vary across settings. We re-assessed the roles of Anopheles arabiensis and Anopheles funestus, and examined potential benefits of species-specific interventions in an area in south-eastern Tanzania, where malaria transmission persists, four years after mass distribution of long-lasting insecticide-treated nets (LLINs). Monthly mosquito sampling was done in randomly selected households in three villages using CDC light traps and back-pack aspirators, between January-2015 and January-2016, four years after the last mass distribution of LLINs in 2011...
2017: PloS One
https://www.readbyqxmd.com/read/28536878/erratum-to-long-lasting-permethrin-impregnated-clothing-protective-efficacy-against-malaria-in-hyperendemic-foci-and-laundering-wearing-and-weathering-effects-on-residual-bioactivity-after-worst-case-use-in-the-rain-forests-of-french-guiana
#2
Bruno Most, Vincent Pommier de Santi, Frédéric Pagès, Marie Mura, Waltraud M Uedelhoven, Michael K Faulde
No abstract text is available yet for this article.
May 23, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28536439/pesticides-in-fine-airborne-particles-from-a-green-analysis-method-to-atmospheric-characterization-and-risk-assessment
#3
Madson M Nascimento, Gisele O da Rocha, Jailson B de Andrade
The intensive use of pesticides such as herbicides, insecticides, fungicides and acaricides has been lead to ubiquitous contamination, being present not only in soils, water bodies and/or crops, but also in the atmosphere. Considering the massive amount of pesticides employed globally, together to their persistence, this may be an important concern regarding air quality and human health worldwide. In the present study we developed a green sensitive sample preparation method for determination of nine organophosphates, two pyrethroids, one carbamate, and one strobirulin in PM2...
May 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28523490/ivermectin-lipid-based-nanocarriers-as-novel-formulations-against-head-lice
#4
Gabriela Ullio-Gamboa, Santiago Palma, Jean Pierre Benoit, Daniel Allemandi, María Inés Picollo, Ariel Ceferino Toloza
The use of pyrethroids to control the human head louse, Pediculus humanus capitis De Geer (Anoplura: Pediculidae), has suffered considerable loss of efficacy due to the evolution of resistance. Thus, the development of efficiently insecticide delivery systems is imperative for the control of head lice. We studied the insecticidal activity of ivermectin-loaded lipid nanocapsules (IVM-LNC) against permethrin-resistant head lice from Argentina. The LNC, prepared by a phase inversion procedure, were characterized in terms of size, surface potential, and physical stability...
May 18, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28505888/fipronil-washoff-to-municipal-wastewater-from-dogs-treated-with-spot-on-products
#5
Jennifer Teerlink, Jorge Hernandez, Robert Budd
Fipronil and fipronil degradates have been reported in treated wastewater effluent at concentrations that exceed USEPA Aquatic Life Benchmarks, posing a potential risk to the surface waters to which they discharge. Fipronil is a common insecticide found in spot-on flea and tick treatment products that have the potential for down-the-drain transport and direct washoff into surface water. Volunteers currently treating their dogs with a fipronil-containing spot-on product were recruited. Dogs were washed either 2, 7, or 28days after product application, and rinsate from 34 discrete bathing events were analyzed by LC-MS/MS for fipronil and fipronil degradates (collectively known as fiproles)...
May 11, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28495520/brain-uptake-of-deltamethrin-in-rats-as-a-function-of-plasma-protein-binding-and-blood-brain-barrier-maturation
#6
Manoj Amaraneni, Jing Pang, Tanzir B Mortuza, Srinivasa Muralidhara, Brian S Cummings, Catherine A White, Charles V Vorhees, Jason Zastre, James V Bruckner
Pyrethroids, including permethrin and deltamethrin (DLM), are very widely used of insecticides. It was hypothesized that lower plasma binding and increased blood-brain barrier (BBB) penetration of DLM in immature rats contribute to the higher brain concentrations of DLM and more pronounced neurotoxicity reported in this age group. The left brain of anesthetized adult rats was perfused for 2min via a carotid artery with 1μM (14)C-DLM in: 2-5% human serum albumin (HSA); plasma from adult and 15- and 21-d-old rats; and plasma from human donors of: birth-1 week, 1-4 weeks, 4 weeks-1 year, 1-3 years and adults...
May 8, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28493716/bifenthrin-causes-toxicity-in-urban-stormwater-wetlands-field-and-laboratory-assessment-using-austrochiltonia-amphipoda
#7
Katherine Joanna Jeppe, Claudette Robin Kellar, Stephen Marshall, Valentina Colombo, Georgia May Sinclair, Vincent J Pettigrove
Stormwater wetlands are engineered to accumulate sediment and pollutants from stormwater and provide environmental value to urban environments. Therefore, contaminated sediment risks causing toxicity to aquatic fauna. This research identifies contaminants of concern in urban wetland sediments by assessing sediment toxicity using the amphipod Austrochiltonia subtenuis. Sediments from 99 wetlands were analyzed for contaminants and laboratory bioassays were performed with A. subtenuis. Wild Austrochiltonia spp...
May 11, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28472570/scabies-a-clinical-update
#8
Myra Hardy, Daniel Engelman, Andrew Steer
BACKGROUND: Scabies is a common, yet neglected, skin disease. Scabies occurs across Australia, but most frequently in socioeconomically disadvantaged populations in tropical regions, including in remote Aboriginal and Torres Strait Islander communities. In temperate settings, the disease clusters in institutional care facilities. OBJECTIVE: The objective of this article is to provide updates on the clinical diagnosis and treatment approaches for scabies in Australia...
2017: Australian Family Physician
https://www.readbyqxmd.com/read/28469858/case-report-a-new-method-for-treatment-of-permethrin-resistant-head-lice
#9
Farhad Jahangiri
Head lice (Pediculus humanus capitis) infestation is an important disease worldwide, especially in children under 11 years old. Permethrin is the most common insecticide for treatment of human pediculosis, but nowadays resistance to permethrin and other pyrethroids has caused many treatment failures. The second treatment of choice is malathion.
May 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28456543/subchronic-toxicity-of-low-dose-propoxur-permethrin-and-their-combination-on-the-redox-status-of-rat-liver
#10
Pan Wang, Ming-Yuan Xu, Yu-Jie Liang, Hui-Ping Wang, Ying-Jian Sun, Ding-Xin Long, Yi-Jun Wu
Carbamates and pyrethroids are widely used pesticides. However, their joint toxicity at low doses with long-term exposure remains unknown. Therefore, we investigated the subchronic joint hepatotoxicity of the two representative pesticides within these two classes, i.e., propoxur (PR) and permethrin (PE) in rats. The male Wistar rats were orally treated with three different doses of PR, PE and their mixtures for 90 consecutive days. Liver weight, serum clinical chemistry parameters and histopathological changes were measured to access the hepatotoxicity...
April 26, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28454576/a-field-trial-of-a-fixed-combination-of-permethrin-and-fipronil-effitix-%C3%A2-for-the-treatment-and-prevention-of-flea-infestation-in-dogs-living-with-sheep
#11
Manolis K Chatzis, Dimitris Psemmas, Elias Papadopoulos, Christelle Navarro, Manolis N Saridomichelakis
BACKGROUND: A large number of fleas parasitize dogs living with sheep in Greece. The primary aim of this randomized, blinded, placebo-controlled trial was to examine the efficacy of a permethrin-fipronil combination (Effitix(®)) for the treatment and prevention of flea infestation in dogs living with sheep and the secondary aim was to examine the efficacy of this intervention on flea infestation, pruritus and skin lesions of the people in contact with these dogs. METHODS: Thirty dogs living with sheep and infested by at least 10 fleas and all 80 sheep living on the same premises were randomly allocated into equal groups...
April 28, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28453973/determinants-of-children-s-exposure-to-pyrethroid-insecticides-in-western-france
#12
Philippe Glorennec, Tania Serrano, Morgane Fravallo, Charline Warembourg, Christine Monfort, Sylvaine Cordier, Jean-François Viel, Florent Le Gléau, Barbara Le Bot, Cécile Chevrier
Pyrethroids are insecticides frequently used in agriculture and in the home; exposure occurs through dietary and non-dietary pathways, including indoor and outdoor environmental contamination. Our objective was to study the potential determinants of pyrethroid metabolite concentrations measured in children's urine samples and in the dust of their homes. Specifically, we measured urinary metabolites from morning spot samples of 245 six-year-old children living in Brittany (France) in 2009-2012 and from dust vacuumed from the floor of their homes...
April 25, 2017: Environment International
https://www.readbyqxmd.com/read/28453542/phospholipid-profiling-of-plasma-from-gw-veterans-and-rodent-models-to-identify-potential-biomarkers-of-gulf-war-illness
#13
Tanja Emmerich, Zuchra Zakirova, Nancy Klimas, Kimberly Sullivan, Ashok K Shetty, James E Evans, Ghania Ait-Ghezala, Gary S Laco, Bharathi Hattiangady, Geetha A Shetty, Michael Mullan, Gogce Crynen, Laila Abdullah, Fiona Crawford
Gulf War Illness (GWI), which affects at least one fourth of the 700,000 veterans deployed to the Gulf War (GW), is characterized by persistent and heterogeneous symptoms, including pain, fatigue and cognitive problems. As a consequence, this illness remains difficult to diagnose. Rodent models have been shown to exhibit different symptomatic features of GWI following exposure to particular GW agents (e.g. pyridostigmine bromide, permethrin and DEET) and/or stress. Preclinical analyses have shown the activation of microglia and astroglia as a pathological hallmark in these mouse and rat models...
2017: PloS One
https://www.readbyqxmd.com/read/28445697/influence-of-maturation-on-in-vivo-tissue-to-plasma-partition-coefficients-for-cis-and-trans-permethrin
#14
Manoj Amaraneni, Jing Pang, James V Bruckner, Srinivasa Muralidhara, Tanzir B Mortuza, Darren Gullick, Shirin Hooshfar, Catherine A White, Brian S Cummings
Permethrin, the most widely used household insecticide in the U.S., is marketed as a mixture of its cis (CIS) and trans (TRANS) isomers. The major objective of this investigation was to develop and utilize a reliable approach to determine in vivo partition coefficients (PCs) for CIS and TRANS in immature and adult Sprague-Dawley rats. Adult, postnatal day (PND) 21 and PND 15 rats were infused with environmentally relevant concentrations of CIS or TRANS via a s.c. osmotic pump for 48 or 72 h. The adult and PND 21 rats also received an oral loading dose...
April 23, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28437449/insecticide-resistance-status-of-malaria-vectors-in-lao-pdr
#15
Sébastien Marcombe, Julie Bobichon, Boutsady Somphong, Nothasin Phommavan, Santi Maithaviphet, Simone Nambanya, Vincent Corbel, Paul T Brey
Knowledge on insecticide resistance in Anopheles species is a basic requirement to guide malaria vector control programs. In Lao PDR, vector control relies on insecticide residual spraying (IRS) and impregnated bed-nets (ITNs) with the use of pyrethroids. Here, the susceptibility of Anopheles species, including several malaria vectors (An. maculatus and An. minimus), to various insecticides was investigated in ten provinces of Lao PDR through a north-south transect. Bioassays were performed on field caught female mosquitoes using the standard WHO susceptibility tests with DDT (4%), deltamethrin (0...
2017: PloS One
https://www.readbyqxmd.com/read/28431163/an-evaluation-of-the-human-relevance-of-the-lung-tumors-observed-in-female-mice-treated-with-permethrin-based-on-mode-of-action
#16
Tomoya Yamada, Miwa Kondo, Kaori Miyata, Keiko Ogata, Masahiko Kushida, Kayo Sumida, Satoshi Kawamura, Thomas G Osimitz, Brian G Lake, Samuel M Cohen
Permethrin increased the incidence of bronchiolo-alveolar adenomas in female mice but not male mice or female or male rats. Studies were conducted to determine whether permethrin has mitogenic activity in Club cells in mouse lung as the basis for the mode of action (MOA) for the lung adenoma induction. Several short term experiments focusing on time-course, dose-response, reversibility, sex difference, strain difference, and species difference were evaluated for Club cell proliferation and morphology. The findings demonstrated that permethrin slightly and continuously enhanced Club cell proliferation at tumor-associated dose levels in female mice, but did not increase proliferation in male mice or in female rats...
April 18, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28428243/genome-wide-transcription-and-functional-analyses-reveal-heterogeneous-molecular-mechanisms-driving-pyrethroids-resistance-in-the-major-malaria-vector-anopheles-funestus-across-africa
#17
Jacob M Riveron, Sulaiman S Ibrahim, Charles Mulamba, Rousseau Djouaka, Helen Irving, Murielle J Wondji, Intan H Ishak, Charles S Wondji
Pyrethroid resistance in malaria vector, An. Funestus is increasingly reported across Africa, threatening the sustainability of pyrethroid-based control interventions including long lasting insecticidal Nets (LLINs). Managing this problem requires understanding of the molecular basis of the resistance from different regions of the continent, to establish whether it is being driven by a single or independent selective events. Here, using a genome-wide transcription profiling of pyrethroid resistant populations from Southern (Malawi), East (Uganda) and West Africa (Benin), we investigated the molecular basis of resistance, revealing strong differences between the different African regions...
April 19, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/28427447/benchmarking-insecticide-resistance-intensity-bioassays-for-anopheles-malaria-vector-species-against-resistance-phenotypes-of-known-epidemiological-significance
#18
Nelius Venter, Shȕné V Oliver, Mbanga Muleba, Craig Davies, Richard H Hunt, Lizette L Koekemoer, Maureen Coetzee, Basil D Brooke
BACKGROUND: Insecticide use via indoor residual spraying (IRS) or treated nets is the primary method for controlling malaria vector populations. The incidence of insecticide resistance in vector populations is burgeoning globally making resistance management key to the design of effective malaria control and elimination strategies. Vector populations can be assessed for insecticide resistance using a binary (susceptible or resistant) classification based on the use of the standard WHO insecticide susceptibility assay for adult anopheline mosquitoes...
April 20, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28424101/limited-impacts-of-truck-based-ultra-low-volume-applications-of-mosquito-adulticides-on-mortality-in-honey-bees-apis-mellifera
#19
F D Rinkevich, J W Margotta, V Pokhrel, T W Walker, R H Vaeth, W C Hoffman, B K Fritz, R G Danka, T E Rinderer, R L Aldridge, K J Linthicum, J A Ottea, K B Healy
Adulticides applied against mosquitoes can reduce vector populations during times of high arbovirus transmission. However, impacts of these insecticides on pollinators and other non-target organisms are of concern to mosquito control professionals, beekeepers and others. We evaluated mortality of Culex quinquefasciatus and Apis mellifera when caged insects were exposed to low and high label rates of four common adulticides (Aqua-Pursuit™ [permethrin], Duet® [prallethrin + sumithrin], Fyfanon® [malathion] and Scourge® [resmethrin]) at six distances up to 91...
April 20, 2017: Bulletin of Entomological Research
https://www.readbyqxmd.com/read/28421653/permethrin-and-malathion-ld90-values-for-culex-quinquefasciatus-vary-with-topical-application-site
#20
R L Aldridge, P E Kaufman, J R Bloomquist, S A Gezan, K J Linthicum
Prior research in multiple insect species has demonstrated that insecticide-induced mortality varies according to the body region exposed on the insect. This variation has been demonstrated in Culex quinquefasciatus Say (Diptera: Culicidae), but has not been quantified using dose-response curves. Applications of technical permethrin or malathion to one of three body regions on Cx. quinquefasciatus resulted in dose-response curves that were not equivalent to one another. The generated LD90 values and curves for each body region were compared with previously reported LD values for analogous sites in several mosquito species, specifically the mesothorax...
April 19, 2017: Medical and Veterinary Entomology
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