keyword
https://read.qxmd.com/read/38535458/using-constellation-pharmacology-to-characterize-a-novel-%C3%AE-conotoxin-from-conus-ateralbus
#1
JOURNAL ARTICLE
Jorge L B Neves, Cristoval Urcino, Kevin Chase, Cheryl Dowell, Arik J Hone, David Morgenstern, Victor M Chua, Iris Bea L Ramiro, Julita S Imperial, Lee S Leavitt, Jasmine Phan, Fernando A Fisher, Maren Watkins, Shrinivasan Raghuraman, Jortan O Tun, Beatrix M Ueberheide, J Michael McIntosh, Vitor Vasconcelos, Baldomero M Olivera, Joanna Gajewiak
The venom of cone snails has been proven to be a rich source of bioactive peptides that target a variety of ion channels and receptors. α-Conotoxins (αCtx) interact with nicotinic acetylcholine receptors (nAChRs) and are powerful tools for investigating the structure and function of the various nAChR subtypes. By studying how conotoxins interact with nAChRs, we can improve our understanding of these receptors, leading to new insights into neurological diseases associated with nAChRs. Here, we describe the discovery and characterization of a novel conotoxin from Conus ateralbus , αCtx-AtIA, which has an amino acid sequence homologous to the well-described αCtx-PeIA, but with a different selectivity profile towards nAChRs...
February 29, 2024: Marine Drugs
https://read.qxmd.com/read/38535451/rational-design-of-potent-%C3%AE-conotoxin-peia-analogues-with-non-natural-amino-acids-for-the-inhibition-of-human-%C3%AE-9%C3%AE-10-nicotinic-acetylcholine-receptors
#2
JOURNAL ARTICLE
Tianmiao Li, Han-Shen Tae, Jiazhen Liang, Zixuan Zhang, Xiao Li, Tao Jiang, David J Adams, Rilei Yu
α-Conotoxins (α-CTxs) are structurally related peptides that antagonize nicotinic acetylcholine receptors (nAChRs), which may serve as new alternatives to opioid-based treatment for pain-related conditions. The non-natural amino acid analogues of α-CTxs have been demonstrated with improved potency compared to the native peptide. In this study, we chemically synthesized Dab/Dap-substituted analogues of α-CTx PeIA and evaluated their activity at heterologously expressed human α9α10 nAChRs...
February 27, 2024: Marine Drugs
https://read.qxmd.com/read/38532858/anthranilic-acid-a-gpr109a-agonist-and-schizophrenia
#3
JOURNAL ARTICLE
Gregory Oxenkrug, Brent Forester
INTRODUCTION: Limited clinical efficiency of current medications warrants search for new antipsychotic agents. Deorphanized G-protein coupled receptor (GPR)109A has not attracted much of attention of schizophrenia researchers. We analyzed literature and our data on endogenous agonists of GPR109A, beta-hydroxybutyrate (BHB), anthranilic (AA), butyric (BA), and nicotinic (NA) acids, in individuals with schizophrenia. DATA: Sex specific differences: plasma AA levels were 27% higher in female than in male patients and correlated with PANSS before 6 weeks of antipsychotics treatment ( r  = ...
2024: International Journal of Tryptophan Research: IJTR
https://read.qxmd.com/read/38531835/identifying-plasma-metabolic-characteristics-of-major-depressive-disorder-bipolar-disorder-and-schizophrenia-in-adolescents
#4
JOURNAL ARTICLE
Bangmin Yin, Yuping Cai, Teng Teng, Xiaolin Wang, Xueer Liu, Xuemei Li, Jie Wang, Hongyan Wu, Yuqian He, Fandong Ren, Tianzhang Kou, Zheng-Jiang Zhu, Xinyu Zhou
Major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia (SCZ) are classified as major mental disorders and together account for the second-highest global disease burden, and half of these patients experience symptom onset in adolescence. Several studies have reported both similar and unique features regarding the risk factors and clinical symptoms of these three disorders. However, it is still unclear whether these disorders have similar or unique metabolic characteristics in adolescents. We conducted a metabolomics analysis of plasma samples from adolescent healthy controls (HCs) and patients with MDD, BD, and SCZ...
March 26, 2024: Translational Psychiatry
https://read.qxmd.com/read/38523150/fe-3-o-4-chitosan-zif-8-rvg29-an-anti-glioma-nanoplatform-guided-by-fixed-and-activated-by-alternating-magnetic-field
#5
JOURNAL ARTICLE
Mohammad-Nabil Savari
There is considerable interest in developing anti-glioma nanoplatforms. They make the all-in-one combination of therapies possible. Here we show how the selective Glioblastoma multiforme (GBM) cell killing of the here-established nanoplatforms increased after each coating and how the here-established vibration-inducing Alternating magnetic field (AMF) decreased the treatment time from 72 h to 30 s. Thanks to their magnetite core, these nanoplatforms can be guided to the tumor's specific site by a Fixed magnetic field, they bypass the Blood-Brain Barrier (BBB) and accumulate at the tumor site thanks to the RVG29 bonding to the G-protein on the ion-gated channel receptor known as the nicotinic acetylcholine receptor (nAchR), which expresses on BBB cells and overexpresses on GBM cells, and thanks to the positive charge gained by both chitosan and RVG29's peptide...
March 24, 2024: Scientific Reports
https://read.qxmd.com/read/38517647/a-new-co-ii-coordination-polymer-fluorescence-performances-loaded-with-paclitaxel-hydrogel-on-breast-cancer-and-molecular-docking-study
#6
JOURNAL ARTICLE
Lijun Di, Zhihong Lv, Haiping Zhang, Hui Li
In the current context of the increasing incidence of breast cancer, we aim to develop an efficient drug carrier for breast cancer by constructing an innovative complex consisting of a metal-organic framework (MOF) and a hydrogel. The aim of this initiative is to provide new ideas and tools for breast cancer treatment strategies through scientific research, so as to address the current challenges in breast cancer treatment. In the present study, by employment of a new Co(II)-based coordination polymer with the chemical formula of [Co(H2 O)(CH3 OH)L]n (1) (H2 L = 5-(1 H-tetrazol-5-yl)nicotinic acid) was solvothermally synthesized by reaction of Co(NO3 )2 ·6H2 O a mixed solvent of MeOH and water...
March 22, 2024: Journal of Fluorescence
https://read.qxmd.com/read/38513929/activation-of-alpha-7-nicotinic-acetylcholine-receptor-by-tropisetron-mitigates-3-nitropropionic-acid-induced-huntington-s-disease-in-rats-role-of-pi3k-akt-and-jak2-nf-%C3%AE%C2%BAb-signaling-pathways
#7
JOURNAL ARTICLE
Mostafa A Rabie, Ahmed T Ghoneim, Mohamed I Fahmy, Mohammed F El-Yamany, Rabab H Sayed
Huntington's disease (HD) is an inheritable autosomal-dominant disorder that targets mainly the striatum. 3-Nitropropionic acid (3-NP) induces obvious deleterious behavioral, neurochemical, and histological effects similar to the symptoms of HD. Our study aimed to examine the neuroprotective activity of tropisetron, an alpha-7 neuronal nicotinic acetylcholine receptor (α-7nAChR) agonist, against neurotoxic events associated with 3-NP-induced HD in rats. Forty-eight rats were randomly allocated into four groups...
March 19, 2024: Chemico-biological Interactions
https://read.qxmd.com/read/38513779/a-metabolomics-approach-reveals-metabolic-disturbance-of-human-cholangiocarcinoma-cells-after-parthenolide-treatment
#8
JOURNAL ARTICLE
Yongping He, Qianxue Yu, Xiaoyu Ma, Diya Lv, Hui Wang, Weian Qiu, Xiao Fei Chen, Yang Jiao, Yue Liu
ETHNOPHARMACOLOGICAL RELEVANCE: Tanacetum parthenium (L.) Schultz-Bip, commonly known as feverfew, has been traditionally used to treat fever, migraines, rheumatoid arthritis, and cancer. Parthenolide (PTL), the main bioactive ingredient isolated from the shoots of feverfew, is a sesquiterpene lactone with anti-inflammatory and antitumor properties. Previous studies showed that PTL exerts anticancer activity in various cancers, including hepatoma, cholangiocarcinoma, acute myeloid leukemia, breast, prostate, and colorectal cancer...
March 19, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38505670/essential-role-of-cd38-in-platelet-aggregation-through-the-pkc-mediated-internalization-and-activation
#9
JOURNAL ARTICLE
Mazhar Mushtaq, Maira Mahmood, Uzma Jabbar, Uh-Hyun Kim
INTRODUCTION: CD38 is a multifunctional enzyme with a potent Ca2+ mobilizing effect, cyclic ADP-ribose (cADPR), and nicotinic acid adenine dinucleotide phosphate (NAADP). Here, we aimed to demonstrate the role of CD38 in platelets via protein kinase C (PKC)-mediated internalization and activation. METHODS: Mouse platelets were used in this study. Thrombin, an agonist of platelet function, provoked a prompt and long-lasting increase in intracellular Ca2+ concentration ([Ca2+ ]i), resulting from an interplay of multifold Ca2+ mobilizing messengers...
2024: BioImpacts: BI
https://read.qxmd.com/read/38476136/invasive-ant-learning-is-not-affected-by-seven-potential-neuroactive-chemicals
#10
JOURNAL ARTICLE
Henrique Galante, Tomer J Czaczkes
Argentine ants Linepithema humile are one of the most damaging invasive alien species worldwide. Enhancing or disrupting cognitive abilities, such as learning, has the potential to improve management efforts, for example by increasing preference for a bait, or improving ants' ability to learn its characteristics or location. Nectar-feeding insects are often the victims of psychoactive manipulation, with plants lacing their nectar with secondary metabolites such as alkaloids and non-protein amino acids which often alter learning, foraging, or recruitment...
February 2024: Current Zoology
https://read.qxmd.com/read/38453966/a-ketogenic-diet-rich-in-fish-oil-is-superior-to-other-fats-in-preventing-nnk-induced-lung-cancer-in-a-j-mice
#11
JOURNAL ARTICLE
Ingrid Elisia, Michelle Yeung, Sara Kowalski, Taras Shyp, Jason Tee, Serena Hollman, Amy Wong, Janette King, Roger Dyer, Poul H Sorensen, Gerald Krystal
Given that ketogenic diets (KDs) are extremely high in dietary fat, we compared different fats in KDs to determine which was the best for cancer prevention. Specifically, we compared a Western and a 15% carbohydrate diet to seven different KDs, containing either Western fats or fats enriched in medium chain fatty acids (MCTs), milk fat (MF), palm oil (PO), olive oil (OO), corn oil (CO) or fish oil (FO) for their ability to reduce nicotine-derived nitrosamine ketone (NNK)-induced lung cancer in mice. While all the KDs tested were more effective at reducing lung nodules than the Western or 15% carbohydrate diet, the FO-KD was most effective at reducing lung nodules...
March 7, 2024: Scientific Reports
https://read.qxmd.com/read/38450679/the-cytotoxic-and-antiproliferative-properties-of-ruthenium-nitrosyl-complexes-and-their-modulation-effect-on-cytochrome-p450-in-the-hepg2-cell-line
#12
JOURNAL ARTICLE
L S Klyushova, V A Vavilin, A Yu Grishanova
Ruthenium nitrosyl complexes are actively investigated as antitumor agents. Evaluation of potential interactions between cytochromes P450 (CYPs) with new compounds is carried out regularly during early drug development. In this study we have investigated the cytotoxic and antiproliferative activities of ruthenium nitrosyl complexes with methyl/ethyl esters of nicotinic and isonicotinic acids and γ-picoline against 2D and 3D cultures of human hepatocellular carcinoma HepG2 and non-cancer human lung fibroblasts MRC-5, assessed their photoinduced activity at λrad = 445 nm, and also evaluated their modulating effect on CYP3A4, CYP2C9, and CYP2C19...
February 2024: Biomedit︠s︡inskai︠a︡ Khimii︠a︡
https://read.qxmd.com/read/38450359/one-year-evaluation-of-pharmacist-medication-charting-service-in-a-principal-referral-women-and-newborn-hospital
#13
JOURNAL ARTICLE
Stephanie Teoh, Nabeelah Mukadam, Michael Petrovski
Background: Accuracy of medication charts on admission to hospital has previously shown that inadvertent omission of therapy was the most common discrepancy, accounting for 40% to 60% of errors. Partnered Pharmacist Medication Charting (PPMC) has shown to reduce medicationrelated problems. Objective: The aim of this study was to evaluate the implementation of Pharmacist Medication Charting (PMC), a derivative of PPMC, in a maternity and gynecological hospital. The occurrence of medication omission identified by the pharmacists was assessed and the pharmacist interventions involving PMC analyzed...
April 2024: Hospital Pharmacy
https://read.qxmd.com/read/38445598/oleic-acid-could-act-as-a-channel-blocker-in-the-inhibition-of-nachr-insights-from-molecular-dynamics-simulations
#14
JOURNAL ARTICLE
Diego J Obiol, María J Amundarain, Fernando Zamarreño, Agustín Vietri, Silvia S Antollini, Marcelo D Costabel
The activation of the muscular nicotinic acetylcholine receptor (nAChR) produces the opening of the channel, with the consequent increase in the permeability of cations, triggering an excitatory signal. Free fatty acids (FFA) are known to modulate the activity of the receptor as noncompetitive antagonists, acting at the membrane-AChR interface. We present molecular dynamics simulations of a model of nAChR in a desensitized closed state embedded in a lipid bilayer in which distinct membrane phospholipids were replaced by two different monounsaturated FFA that differ in the position of a double bond...
March 6, 2024: Journal of Physical Chemistry. B
https://read.qxmd.com/read/38444949/polyaspartic-acid-increases-potassium-content-and-reduces-the-ratio-of-total-sugar-to-nicotine-in-tobacco-leaves
#15
JOURNAL ARTICLE
Zetao Zhang, Hui Tian, Jinsheng Li, Dian Wang, Xiuwen Wu
Tobacco is an important cash crop in China, but the low potassium (K) content and high ratio of total sugar to nicotine in tobacco leaves have seriously affected the quality of tobacco leaves. As a fertilizer synergist, polyaspartic acid (PASP) can improve the K content in tobacco leaves, but it is unknown how it affects the K content in different parts of tobacco leaves, and how PASP affects the ratio of total sugar to nicotine in tobacco leaves has not been reported. Therefore, "Zhongyan 100" was selected for pot experiments with 5 different PASP addition levels: CK (0...
February 29, 2024: Heliyon
https://read.qxmd.com/read/38441031/in-depth-characterization-of-a-selection-of-gut-commensal-bacteria-reveals-their-functional-capacities-to-metabolize-dietary-carbohydrates-with-prebiotic-potential
#16
JOURNAL ARTICLE
Cassandre Bedu-Ferrari, Paul Biscarrat, Frederic Pepke, Sarah Vati, Cyril Chaudemanche, Florence Castelli, Céline Chollet, Olivier Rué, Christelle Hennequet-Antier, Philippe Langella, Claire Cherbuy
UNLABELLED: The microbial utilization of dietary carbohydrates is closely linked to the pivotal role of the gut microbiome in human health. Inherent to the modulation of complex microbial communities, a prebiotic implies the selective utilization of a specific substrate, relying on the metabolic capacities of targeted microbes. In this study, we investigated the metabolic capacities of 17 commensal bacteria of the human gut microbiome toward dietary carbohydrates with prebiotic potential...
March 5, 2024: MSystems
https://read.qxmd.com/read/38434019/analysis-of-differences-in-aroma-and-sensory-characteristics-of-the-mainstream-smoke-of-six-cigars
#17
JOURNAL ARTICLE
Lin Yang, Lulu Liu, Lingbo Ji, Chenxi Jiang, Zhongrong Jiang, Dongliang Li, Zhen Yang, Wen Cai, Quanwei Zhou, Jinshan Lei, Pinhe Li, Yuhong Jia, Jie Liu, Heng Xu, Jun Hu
Cigars have unique aroma and style characteristics. In order to clarify the differences of aroma components between domestic and imported cigars and the material basis of the stylistic characteristics of different cigars, gas chromatography-mass spectrometry (GC-MS) and sensory evaluation were used to compare and analyze the aroma components in the mainstream smoke of four domestic cigars and two imported cigars. The GC-MS results showed that a total of 97 aroma components were measured in the smoke of the six cigars, and the types of aroma components were similar, but there were differences in their contents...
February 29, 2024: Heliyon
https://read.qxmd.com/read/38417847/chronic-ethanol-intake-impairs-niacin-nutritional-status-in-mice
#18
JOURNAL ARTICLE
Amane Mizutani, Chihiro Goto, Hidetsugu Fujigaki, Yasuko Yamamoto, Kuniaki Saito, Sho Hatayama, Tsutomu Fukuwatari
Niacin is involved in many biological reactions relating energy metabolism, redox reactions, DNA repair and longevity. Since niacin deficiency has been reported in alcoholic patients, and niacin coenzyme NAD is used as substrate to dehydrogenate ethanol in the liver, ethanol consumption can be a factor to impair niacin nutritional status. We have recently established the niacin insufficient model mice using kynurenine 3-monooxygenase knock out (KMO-/- ) mice with niacin-limited diet, which lack the de novo NAD synthesis pathway from tryptophan...
2024: Journal of Nutritional Science and Vitaminology
https://read.qxmd.com/read/38417123/jpt2-affects-trophoblast-functions-and-macrophage-polarization-and-metabolism-and-acts-as-a-potential-therapeutic-target-for-recurrent-spontaneous-abortion
#19
JOURNAL ARTICLE
Xin Chen, Qian Lin Song, Rui Ji, Jia Yu Wang, Ming Liang Cao, Duan Ying Guo, Yan Zhang, Jing Yang
Recurrent spontaneous abortion (RSA) is a pregnancy-related condition with complex etiology. Trophoblast dysfunction and abnormal macrophage polarization and metabolism are associated with RSA; however, the underlying mechanisms remain unknown. Jupiter microtubule-associated homolog 2 (JPT2) is essential for calcium mobilization; however, its role in RSA remains unclear. In this study, it is found that the expression levels of JPT2, a nicotinic acid adenine dinucleotide phosphate-binding protein, are decreased in the villous tissues of patients with RSA and placental tissues of miscarried mice...
February 28, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38409846/salvianolic-acid-b-ameliorated-chemotherapeutic-injury-of-cardiac-myocytes-through-the-nrf2-are-signaling-pathway
#20
JOURNAL ARTICLE
Yaping Wu, Zhenjian Lin, Yuyan Bao, Yuebo Liu, Xiaomin Zhang
BACKGROUND: Cardiotoxicity has been corroborated to be the toxic influence of cisplatin (CDDP). Oxidative stress and cardiomyocyte apoptosis play a vital part in cardiotoxicity induced by CDDP. Salvianolic acid Salvianolic acid B (SalB) is a monomeric component of Salvia miltiorrhiza, which has antioxidant and anti-inflammatory influences. In this research, we explored the mechanism of SalB in cardiotoxicity induced by CDDP. METHOD: 36 Wistar rats were separated into sham subgroup, CDDP (10 mg/kg) subgroup, CDDP (10 mg/kg) + SalB (1 μM) subgroup at random, CDDP (10 mg/kg) + SalB (5 μM) subgroup and CDDP (10 mg/kg) + SalB (10 μM) subgroup, Nicotinic Acid Riboside (NAR, 5 μM), with 6 rats in each subgroup...
February 2024: Discovery Medicine
keyword
keyword
49435
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.