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nicotinic acid

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https://www.readbyqxmd.com/read/28321502/molecularly-imprinted-polymers-as-selective-adsorbents-for-ambient-plasma-mass-spectrometry
#1
Michał Cegłowski, Marek Smoluch, Edward Reszke, Jerzy Silberring, Grzegorz Schroeder
The application of molecularly imprinted polymers (MIPs) as molecular scavengers for ambient plasma ionization mass spectrometry has been reported for the first time. MIPs were synthesized using methacrylic acid as functional monomer; nicotine, propyphenazone, or methylparaben as templates; ethylene glycol dimethacrylate as a cross-linker; and 2,2'-azobisisobutyronitrile as polymerization initiator. To perform ambient plasma ionization experiments, a setup consisting of the heated crucible, a flowing atmospheric-pressure afterglow (FAPA) plasma ion source, and a quadrupole ion trap mass spectrometer has been used...
March 20, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28314204/stability-speciation-and-spectral-properties-of-npo2-complexes-with-pyridine-monocarboxylates-in-aqueous-solution
#2
Rama Mohana Rao Dumpala, Neetika Rawat, B S Tomar
Neptunyl ion as NpO2(+) is the least reacting and most mobile radioactive species among all the actinides. The picolinic acid used for decontamination is co-disposed along with the radioactive waste. Thus, in long term storage of HLW, there is high possibility of interaction of actinides and long lived fission products with the picolinate and can cause migration. The complexation of NpO2(+) with the three structural isomers of pyridine monocarboxylates provides an insight to explore the role of hetero atom (nitrogen) with respect to key binding moiety (carboxylate)...
March 6, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28303787/screening-natural-content-of-water-soluble-b-vitamins-in-fish-enzymatic-extraction-hilic-separation-and-tandem-mass-spectrometric-determination
#3
Niladri Sekhar Chatterjee, K Ashok Kumar, K K Ajeeshkumar, K R Remya Kumari, K V Vishnu, Rangasamy Anandan, Suseela Mathew, C N Ravishankar
Despite the potential of LC with tandem MS (MS/MS) in improving sensitivity and selectivity, analytical methods are scarce for the determination of protein-bound and phosphorylated forms of B vitamins in food. This prompted us to develop a method for LC-MS/MS determination of naturally occurring nicotinamide, nicotinic acid, thiamine, pyridoxine, riboflavin, pantothenic acid, biotin, folic acid, and cyanocobalamin in fish. Baseline separation of the vitamins was achieved in a hydrophilic interaction LC condition...
March 16, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28302506/xanthine-oxidase-inhibitory-activity-of-nicotino-isonicotinohydrazides-a-systematic-approach-from-in-vitro-in-silico-to-in-vivo-studies
#4
Humaira Zafar, Muhammad Hayat, Sumayya Saied, Momin Khan, Uzma Salar, Rizwana Malik, M Iqbal Choudhary, Khalid Mohammed Khan
Change in life style and eating habits has led to an increased prevalence of hyperuricemia worldwide. The role of hyperuricemia is no more restricted to gout, but it has a central role in progression of CVD, hypertension, metabolic syndrome, and arthritis. Among the different factors involved in regulation of serum uric acid, xanthine oxidase (XO) is the best pharmacological target to control the levels of serum uric acid as it catalyzes the final steps in uric acid production. In the current study, a systemic search for the inhibitors of xanthine oxidase, starting from synthesis to in vitro screening and leading to in vivo studies is presented...
February 28, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28273388/enhanced-transport-of-plant-produced-rabies-single-chain-antibody-rvg-peptide-fusion-protein-across-an-in-cellulo-blood-brain-barrier-device
#5
Waranyoo Phoolcharoen, Christophe Prehaud, Craig J van Dolleweerd, Leonard Both, Anaelle da Costa, Monique Lafon, Julian K-C Ma
The biomedical applications of antibody engineering are developing rapidly and have been expanded to plant expression platforms. In the present study, we have generated a novel antibody molecule in planta for targeted delivery across the blood-brain barrier (BBB). Rabies virus (RABV) is a neurotropic virus for which there is no effective treatment after entry into the central nervous system (CNS). This study investigated the use of a RABV glycoprotein peptide sequence to assist delivery of a rabies neutralising single-chain antibody (ScFv) across an in cellulo model of human BBB...
March 8, 2017: Plant Biotechnology Journal
https://www.readbyqxmd.com/read/28273096/benzene-formation-in-electronic-cigarettes
#6
James F Pankow, Kilsun Kim, Kevin J McWhirter, Wentai Luo, Jorge O Escobedo, Robert M Strongin, Anna K Duell, David H Peyton
BACKGROUND/OBJECTIVE: The heating of the fluids used in electronic cigarettes ("e-cigarettes") used to create "vaping" aerosols is capable of causing a wide range of degradation reaction products. We investigated formation of benzene (an important human carcinogen) from e-cigarette fluids containing propylene glycol (PG), glycerol (GL), benzoic acid, the flavor chemical benzaldehyde, and nicotine. METHODS/MAIN RESULTS: Three e-cigarette devices were used: the JUULTM "pod" system (provides no user accessible settings other than flavor cartridge choice), and two refill tank systems that allowed a range of user accessible power settings...
2017: PloS One
https://www.readbyqxmd.com/read/28267333/transcriptional-regulation-of-human-udp-glucuronosyltransferase-2b10-by-farnesoid-x-receptor-in-human-hepatoma-hepg2-cells
#7
Danyi Lu, Shuai Wang, Qian Xie, Lianxia Guo, Baojian Wu
Little is known about transcriptional regulators of UDP-glucuronosyltransferase 2B10 (UGT2B10), an enzyme known to glucuronidate many chemicals and drugs such as nicotine and tricyclic antidepressants. Here, we uncovered that UGT2B10 was transcriptionally regulated by farnesoid X receptor (FXR), the bile acid sensing nuclear receptor. GW4064 and chenodeoxycholic acid (two specific FXR agonists) treatment of HepG2 cells led to a significant increase in the mRNA level of UGT2B10. The treated cells also showed enhanced glucuronidation activities toward amitriptyline (an UGT2B10 probe substrate)...
March 14, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28256591/nicotinic-acid-inhibits-glioma-invasion-by-facilitating-snail1-degradation
#8
Jiejing Li, Jiagui Qu, Yu Shi, Mark Perfetto, Zhuxian Ping, Laura Christian, Hua Niu, Shuting Mei, Qin Zhang, Xiangcai Yang, Shuo Wei
Malignant glioma is a formidable disease that commonly leads to death, mainly due to the invasion of tumor cells into neighboring tissues. Therefore, inhibition of tumor cell invasion may provide an effective therapy for malignant glioma. Here we report that nicotinic acid (NA), an essential vitamin, inhibits glioma cell invasion in vitro and in vivo. Treatment of the U251 glioma cells with NA in vitro results in reduced invasion, which is accompanied by a loss of mesenchymal phenotype and an increase in cell-cell adhesion...
March 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28256030/cloning-and-functional-characterization-of-quinolinic-acid-phosphoribosyl-transferase-qpt-gene-of-nicotiana-tabacum
#9
Sana Khan, Shiv Shanker Pandey, Jyotshna, Karuna Shanker, Feroz Khan, Laiq Ur Rahman
The quinolinic acid phosphoribosyl transferase (QPT) is a key enzyme that converts quinolinic acid into nicotinic acid mononucleotide. The QPT gene plays an essential role in the pyridine nucleotide cycle as well as in the biosynthetic pathway of the alkaloid nicotine. However, a clear role for QPT is yet to be characterized to validate the actual function of this gene in planta. In the present study, an RNAi approach was used to reveal the functional role of QPT. Transformation and analysis of the hairy roots of the Nicotiana leaf explants was used, followed by plant regeneration and analysis...
March 2, 2017: Physiologia Plantarum
https://www.readbyqxmd.com/read/28242176/2017-taiwan-lipid-guidelines-for-high-risk-patients
#10
REVIEW
Yi-Heng Li, Kwo-Chang Ueng, Jiann-Shing Jeng, Min-Ji Charng, Tsung-Hsien Lin, Kuo-Liong Chien, Chih-Yuan Wang, Ting-Hsing Chao, Ping-Yen Liu, Cheng-Huang Su, Shih-Chieh Chien, Chia-Wei Liou, Sung-Chun Tang, Chun-Chuan Lee, Tse-Ya Yu, Jaw-Wen Chen, Chau-Chung Wu, Hung-I Yeh
In Taiwan, the prevalence of hyperlipidemia increased due to lifestyle and dietary habit changes. Low density lipoprotein cholesterol (LDL-C) and non-high density lipoprotein cholesterol (non-HDL-C) are all significant predicting factors of coronary artery disease in Taiwan. We recognized that lipid control is especially important in patients with existed atherosclerotic cardiovascular diseases (ASCVD), including coronary artery disease (CAD), ischemic stroke and peripheral arterial disease (PAD). Because the risk of ASCVD is high in patients with diabetes mellitus (DM), chronic kidney disease (CKD) and familial hypercholesterolemia (FH), lipid control is also necessary in these patients...
February 24, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28240543/integrated-analytical-and-statistical-two-dimensional-spectroscopy-strategy-for-metabolite-identification-application-to-dietary-biomarkers
#11
Joram M Posma, Isabel Garcia-Perez, James C Heaton, Paula Burdisso, John C Mathers, John Draper, Matt Lewis, John C Lindon, Gary Frost, Elaine Holmes, Jeremy K Nicholson
A major purpose of exploratory metabolic profiling is for the identification of molecular species that are statistically associated with specific biological or medical outcomes; unfortunately, the structure elucidation process of unknowns is often a major bottleneck in this process. We present here new holistic strategies that combine different statistical spectroscopic and analytical techniques to improve and simplify the process of metabolite identification. We exemplify these strategies using study data collected as part of a dietary intervention to improve health and which elicits a relatively subtle suite of changes from complex molecular profiles...
March 21, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28239368/connection-of-nicotine-to-diet-induced-obesity-and-non-alcoholic-fatty-liver-disease-cellular-and-mechanistic-insights
#12
REVIEW
Amiya P Sinha-Hikim, Indrani Sinha-Hikim, Theodore C Friedman
Non-alcoholic fatty liver disease (NAFLD) poses a serious health hazard affecting 20-40% of adults in the general population in the USA and over 70% of the obese and extremely obese people. In addition to obesity, nicotine is recognized as a risk factor for NAFLD, and it has been reported that nicotine can exaggerate obesity-induced hepatic steatosis. The development of NAFLD has serious clinical complications because of its potential progression from simple hepatic steatosis to non-alcoholic steatohepatitis (NASH), liver cirrhosis, and hepatocellular carcinoma...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28239341/adeno-associated-viral-vectors-serotype-8-for-cell-specific-delivery-of-therapeutic-genes-in-the-central-nervous-system
#13
Diego Pignataro, Diego Sucunza, Lucia Vanrell, Esperanza Lopez-Franco, Iria G Dopeso-Reyes, Africa Vales, Mirja Hommel, Alberto J Rico, Jose L Lanciego, Gloria Gonzalez-Aseguinolaza
Adeno-associated viruses (AAVs) have become highly promising tools for research and clinical applications in the central nervous system (CNS). However, specific delivery of genes to the cell type of interest is essential for the success of gene therapy and therefore a correct selection of the promoter plays a very important role. Here, AAV8 vectors carrying enhanced green fluorescent protein (eGFP) as reporter gene under the transcriptional control of different CNS-specific promoters were used and compared with a strong ubiquitous promoter...
2017: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/28237557/synthesis-of-1-3-5-trisubstituted-pyrazolines-as-potential-antimalarial-and-antimicrobial-agents
#14
Vikash K Mishra, Mitali Mishra, Varsha Kashaw, Sushil K Kashaw
A series of novel 1,3,5-trisubstituted pyrazolines derivatives have been synthesized from chalcones and nicotinic acid hydrazide in two steps. In first step, chalcones were prepared by treatment of 4-hydroxy acetophenone with different substituted benzaldehyde by Claisen-Schimidt Condensation. In second step, various pyrazoline derivatives were prepared by reflux reaction of chalcones with nicotinic acid hydrazide in ethanolic solution. Compounds were confirmed by elemental analyses, IR, (1)H NMR and (13)C NMR spectral data and were evaluated for antimalarial and antibacterial activity...
February 14, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28225158/solid-state-17-o%C3%A2-nmr-reveals-hydrogen-bonding-energetics-not-all-low-barrier-hydrogen-bonds-are-strong
#15
Jiasheng Lu, Ivan Hung, Andreas Brinkmann, Zhehong Gan, Xianqi Kong, Gang Wu
While NMR and IR spectroscopic signatures and structural characteristics of low-barrier hydrogen bond (LBHB) formation are well documented in the literature, direct measurement of the LBHB energy is difficult. Here, we show that solid-state (17) O NMR spectroscopy can provide unique information about the energy required to break a LBHB. Our solid-state (17) O NMR data show that the HB enthalpy of the O⋅⋅⋅H⋅⋅⋅N LBHB formed in crystalline nicotinic acid is only 7.7±0.5 kcal mol(-1) , suggesting that not all LBHBs are particularly strong...
February 22, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28225105/elucidating-the-biosynthetic-pathways-of-volatile-organic-compounds-in-mycobacterium-tuberculosis-through-a-computational-approach
#16
Purva Bhatter, Karthik Raman, Vani Janakiraman
Microbial volatile organic compounds (VOCs) have gained prominence in the recent past for their potential use as disease markers. The discovery of microbial VOCs has benefited 'difficult to detect' diseases such as tuberculosis (TB). Few of the identified VOCs of Mycobacterium tuberculosis (Mtb) are currently being explored for their diagnostic potential. However, very little is known about the biosynthesis of these small lipophilic molecules. Here, we propose putative biosynthetic pathways in Mycobacterium tuberculosis for three VOCs, namely methyl nicotinate, methyl phenylacetate and methyl p-anisate, using computational approaches...
February 22, 2017: Molecular BioSystems
https://www.readbyqxmd.com/read/28224315/modeling-of-free-fatty-acid-dynamics-insulin-and-nicotinic-acid-resistance-under-acute-and-chronic-treatments
#17
Robert Andersson, Tobias Kroon, Joachim Almquist, Mats Jirstrand, Nicholas D Oakes, Neil D Evans, Michael J Chappel, Johan Gabrielsson
Nicotinic acid (NiAc) is a potent inhibitor of adipose tissue lipolysis. Acute administration results in a rapid reduction of plasma free fatty acid (FFA) concentrations. Sustained NiAc exposure is associated with tolerance development (drug resistance) and complete adaptation (FFA returning to pretreatment levels). We conducted a meta-analysis on a rich pre-clinical data set of the NiAc-FFA interaction to establish the acute and chronic exposure-response relations from a macro perspective. The data were analyzed using a nonlinear mixed-effects framework...
February 21, 2017: Journal of Pharmacokinetics and Pharmacodynamics
https://www.readbyqxmd.com/read/28216063/the-nad-precursor-nicotinic-acid-improves-genomic-integrity-in-human-peripheral-blood-mononuclear-cells-after-x-irradiation
#18
Kathrin Weidele, Sascha Beneke, Alexander Bürkle
NAD(+) is an essential cofactor for enzymes catalyzing redox-reactions as well as an electron carrier in energy metabolism. Aside from this, NAD(+) consuming enzymes like poly(ADP-ribose) polymerases and sirtuins are important regulators involved in chromatin-restructuring processes during repair and epigenetics/transcriptional adaption. In order to replenish cellular NAD(+) levels after cleavage, synthesis starts from precursors such as nicotinamide, nicotinamide riboside or nicotinic acid to match the need for this essential molecule...
February 13, 2017: DNA Repair
https://www.readbyqxmd.com/read/28213944/separation-of-hydroxynorketamine-stereoisomers-using-capillary-electrophoresis-with-sulfated-%C3%AE-cyclodextrin-and-highly-sulfated-%C3%AE-cyclodextrin
#19
Friederike A Sandbaumhüter, Regula Theurillat, Wolfgang Thormann
The racemic N-methyl-d-aspartate receptor antagonist ketamine is used in anesthesia, analgesia and the treatment of depressive disorders. It is known that interactions of hydroxylated norketamine metabolites and 5,6-dehydronorketamine (DHNK) with the α7 -nicotinic acetylcholine receptor and the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor are responsible for the antidepressive effects. Ketamine and its first metabolite norketamine are not active on these receptors. As stereoselectivity plays a role in ketamine metabolism, a cationic capillary electrophoresis based method capable of resolving and analyzing the stereoisomers of four hydroxylated norketamine metabolites, norketamine and DHNK was developed...
February 18, 2017: Electrophoresis
https://www.readbyqxmd.com/read/28208643/synthesis-of-some-new-1-3-4-thiadiazole-thiazole-and-pyridine-derivatives-containing-1-2-3-triazole-moiety
#20
Nadia A Abdelriheem, Ali M M Mohamed, Abdou O Abdelhamid
In this study, 1-(5-Methyl-1-(p-tolyl)-1H-1,2,3-triazol-4-yl)ethan-1-one, was reacted with Thiosemicarbazide, alkyl carbodithioate and benzaldehyde to give thiosemicarbazone, alkylidenehydrazinecarbodithioate and 3-phenylprop-2-en-1-one-1,2,3-triazole derivatives. The 1,3,4-thiadiazole derivatives containing the 1,2,3-triazole moiety were obtained via reaction of alkylidenecarbodithioate with hydrazonoyl halides. Also, hydrazonoyl halides were reacted with thiosemicarbazone and pyrazolylthioamide to give 1,3-thiazoles derivatives...
February 10, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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