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https://www.readbyqxmd.com/read/28904017/eliciting-improved-antibacterial-efficacy-of-host-proteins-in-the-presence-of-antibiotics
#1
Joanna Jammal, Fadia Zaknoon, Amram Mor
We recently reported the aptitude of a membrane-active lipopeptide (C10OOc12O) to sensitize gram-negative bacilli (GNB) to host antibacterial proteins. Here we explored the potential of harnessing such capacity in the presence of antibiotics. For this purpose, we compared Escherichia coli sensitization to antibiotics in broth and plasma; assessed inner and outer membrane damages using scanning electron microscopy, dyes, and mutant strains; and assessed the ability to affect disease course using the mouse peritonitis-sepsis model for mono- and combination therapies...
September 13, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28903718/understanding-the-mba-gender-gap-women-respond-to-gender-norms-by-reducing-public-assertiveness-but-not-private-effort
#2
Aaron S Wallen, Michael W Morris, Beth A Devine, Jackson G Lu
Women's underperformance in MBA programs has been the subject of recent debate and policy interventions, despite a lack of rigorous evidence documenting when and why it occurs. The current studies document a performance gap, specifying its contours and contributing factors. Two behaviors by female students that may factor into the gap are public conformity and private internalization. We predicted that women conform to the norm associating maleness with technical prowess by minimizing their public assertiveness in class discussions and meetings, but that they do not internalize the norm by reducing private effort...
August 2017: Personality & Social Psychology Bulletin
https://www.readbyqxmd.com/read/28900615/exploring-genetic-numeracy-skills-in-a-sample-of-u-s-university-students
#3
Margo W Bergman, Patricia Goodson, Heather Honoré Goltz
Misconceptions concerning numerical genetic risk exist even within educated populations. To more fully characterize and understand the extent of these risk misunderstandings, which have large potential impact on clinical care, we analyzed the responses from 2,576 students enrolled at 2 Southwestern universities using the PGRID tool, a 138-item web-based survey comprising measures of understanding of genetics, genetic disease, and genetic risk. The primary purpose of this study was to characterize the intersection of risk perception and knowledge, termed genetic numeracy (GN)...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28892186/investigating-the-impact-of-innate-dexterity-skills-and-visuospatial-aptitude-on-the-performance-of-baseline-laparoscopic-skills-in-veterinary-students
#4
Mathew R A MacCormick, Jessica J Kilkenny, Meagan Walker, Alex Zur Linden, Ameet Singh
OBJECTIVE: To determine if manual dexterity and visuospatial skills can be used to predict baseline laparoscopic surgery skills in veterinary students. STUDY DESIGN: Pilot study. METHODS: Veterinary students (n = 45) from years 1-4 volunteered for this study. An hour-long electronic questionnaire was completed by participants. The first section was used to collect demographics and information about prior nonsurgical experiences. The second section included 3 tests of visuospatial skills, including the Purdue Visualization of Rotations Test, Mental Rotations Test, and Raven's Advanced Progressive Matrices Test...
September 11, 2017: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/28884999/near-infrared-trigged-stimulus-responsive-photonic-crystals-with-hierarchical-structures
#5
Tao Lu, Hui Pan, Jun Ma, Yao Li, Shenmin Zhu, Di Zhang
Stimuli-responsive photonic crystals (PCs) trigged by light would provide a novel intuitive and quantitative method for noninvasive detection. Inspired by the flame-detecting aptitude of fire beetles and the hierarchical photonic structures of butterfly wings, we herein developed near-infrared stimuli-responsive PCs through coupling photothermal Fe3O4 nanoparticles with thermoresponsive poly(N-isopropylacrylamide) (PNIPAM), with hierarchical photonic structured butterfly wing scales as the template. The nanoparticles within 10 seconds transferred near-infrared radiation into heat that triggered the phase transition of PNIPAM; this almost immediately posed an anticipated effect on the PNIPAM refractive index, and resulted in a composite spectrum change of ~26 nm, leading to the direct visual readout...
September 8, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28880883/multi-scale-modelling-to-evaluate-building-energy-consumption-at-the-neighbourhood-scale
#6
Dasaraden Mauree, Silvia Coccolo, Jérôme Kaempf, Jean-Louis Scartezzini
A new methodology is proposed to couple a meteorological model with a building energy use model. The aim of such a coupling is to improve the boundary conditions of both models with no significant increase in computational time. In the present case, the Canopy Interface Model (CIM) is coupled with CitySim. CitySim provides the geometrical characteristics to CIM, which then calculates a high resolution profile of the meteorological variables. These are in turn used by CitySim to calculate the energy flows in an urban district...
2017: PloS One
https://www.readbyqxmd.com/read/28877098/a-3-dimensional-printed-ultrasound-probe-visuospatial-trainer
#7
Ryan T McKenna, Jesse C Dove, Robert A Ratzlaff, Jose L Diaz-Gomez, Daniel J Cox, Leslie V Simon
Training adult learners to use ultrasound in clinical practice relies on the ability of the learner to apply visuospatial concepts to the anatomy of the human body. We describe a visuospatial trainer that replicates the housing of an ultrasound transducer, through which a linear laser projects light in the same plane and orientation as the ultrasonic sound waves. We use this trainer in combination with a porcine heart dissection laboratory to teach bedside cardiac ultrasound and transthoracic echocardiography (TTE)...
September 4, 2017: Ultrasound Quarterly
https://www.readbyqxmd.com/read/28869802/deadly-experience-the-association-between-firing-a-gun-and-various-aspects-of-suicide-risk
#8
Michael D Anestis, Daniel W Capron
Firearms account for half of all U.S. suicide deaths, but research on mechanisms through which firearms confer risk is limited. Although research has indicated firearm ownership and the unsafe storage of firearms are associated with an elevated risk of suicide, such research cannot provide insight into the extent to which a history of using a gun plays a role. We recruited a community sample (N = 100; 76% female; 44% Black) oversampled for prior suicidal behavior in a high gun ownership state (Mississippi)...
September 4, 2017: Suicide & Life-threatening Behavior
https://www.readbyqxmd.com/read/28860227/the-relationship-between-school-type-and-academic-performance-at-medical-school-a-national-multi-cohort-study
#9
Ben Kumwenda, Jennifer A Cleland, Kim Walker, Amanda J Lee, Rachel Greatrix
OBJECTIVES: Differential attainment in school examinations is one of the barriers to increasing student diversity in medicine. However, studies on the predictive validity of prior academic achievement and educational performance at medical school are contradictory, possibly due to single-site studies or studies which focus only on early years' performance. To address these gaps, we examined the relationship between sociodemographic factors, including school type and average educational performance throughout medical school across a large number of diverse medical programmes...
August 31, 2017: BMJ Open
https://www.readbyqxmd.com/read/28852917/perceptual-training-of-second-language-vowels-does-musical-ability-play-a-role
#10
Payam Ghaffarvand Mokari, Stefan Werner
The present study attempts to extend the research on the effects of phonetic training on the production and perception of second-language (L2) vowels. We also examined whether success in learning L2 vowels through high-variability intensive phonetic training is related to the learners' general musical abilities. Forty Azerbaijani learners of Standard Southern British English participated in a pre-test/training/post-test setting. Discrimination and production tests were used in pre- and post-tests. The participants' musical ability was evaluated through three musical aptitude tests...
August 29, 2017: Journal of Psycholinguistic Research
https://www.readbyqxmd.com/read/28846438/my-secret-life
#11
Mary-Dell Chilton
In my early childhood, my parents gave me to my maternal grandparents for a "visit" that extended over a period of nine years. I seemed to be a fairly ordinary student in primary grades, and had to take a remedial general science class upon entering high school, my first exposure to science. It was the teacher of that class, Mr. Auer, who told me that I had scored amazingly high on a science aptitude test given to all freshmen. The people who administered the testing were convinced that I must have cheated somehow...
August 28, 2017: Annual Review of Plant Biology
https://www.readbyqxmd.com/read/28844884/effect-of-sulfonylurea-tribenuron-methyl-herbicide-on-soil-actinobacteria-growth-and-characterization-of-resistant-strains
#12
Kounouz Rachedi, Ferial Zermane, Radja Tir, Fatima Ayache, Robert Duran, Béatrice Lauga, Solange Karama, Maryse Simon, Abderrahmane Boulahrouf
Repeated application of pesticides disturbs microbial communities and cause dysfunctions on soil biological processes. Granstar(®) 75 DF is one of the most used sulfonylurea herbicides on cereal crops; it contains 75% of tribenuron-methyl. Assessing the changes on soil microbiota, particularly on the most abundant bacterial groups, will be a useful approach to determine the impact of Granstar(®) herbicide. For this purpose, we analyzed Actinobacteria, which are known for their diversity, abundance, and aptitude to resist to xenobiotic substances...
August 9, 2017: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
https://www.readbyqxmd.com/read/28834106/%C3%AE-carbonyl-cations-in-sulfoxide-driven-oxidative-cyclizations
#13
Tobias Stopka, Meike Niggemann, Nuno Maulide
A selective, metal-free generation of α-carbonyl cations from simple internal alkynes was accomplished by addition of a sulfoxide to a congested vinyl cation. The high reactivity of the thus generated α-carbonyl cations was found to efficiently induce hydrogen- and even carbon shift reactions with unusual selecivities. Thereby, complex and highly congested tertiary and quartenary, all-carbon-substituted centers are accessed in a single step from simple precursors. Mechanistic analysis strongly supports the intermediacy of the title species and provides a simple predictive scheme for the migratory aptitude of different substituents...
August 21, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28807002/high-resolution-measurement-of-duf1220-domain-copy-number-from-whole-genome-sequence-data
#14
David P Astling, Ilea E Heft, Kenneth L Jones, James M Sikela
BACKGROUND: DUF1220 protein domains found primarily in Neuroblastoma BreakPoint Family (NBPF) genes show the greatest human lineage-specific increase in copy number of any coding region in the genome. There are 302 haploid copies of DUF1220 in hg38 (~160 of which are human-specific) and the majority of these can be divided into 6 different subtypes (referred to as clades). Copy number changes of specific DUF1220 clades have been associated in a dose-dependent manner with brain size variation (both evolutionarily and within the human population), cognitive aptitude, autism severity, and schizophrenia severity...
August 14, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28803877/face-pareidolia-in-the-rhesus-monkey
#15
Jessica Taubert, Susan G Wardle, Molly Flessert, David A Leopold, Leslie G Ungerleider
Face perception in humans and nonhuman primates is rapid and accurate [1-4]. In the human brain, a network of visual-processing regions is specialized for faces [5-7]. Although face processing is a priority of the primate visual system, face detection is not infallible. Face pareidolia is the compelling illusion of perceiving facial features on inanimate objects, such as the illusory face on the surface of the moon. Although face pareidolia is commonly experienced by humans, its presence in other species is unknown...
August 21, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28801254/the-effect-of-visual-parameters-on-neural-activation-during-nonsymbolic-number-comparison-and-its-relation-to-math-competency
#16
Eric D Wilkey, Jordan C Barone, Michèle M M Mazzocco, Stephan E Vogel, Gavin R Price
Nonsymbolic numerical comparison task performance (whereby a participant judges which of two groups of objects is numerically larger) is thought to index the efficiency of neural systems supporting numerical magnitude perception, and performance on such tasks has been related to individual differences in math competency. However, a growing body of research suggests task performance is heavily influenced by visual parameters of the stimuli (e.g. surface area and dot size of object sets) such that the correlation with math is driven by performance on trials in which number is incongruent with visual cues...
August 8, 2017: NeuroImage
https://www.readbyqxmd.com/read/28800956/adult-hippocampal-neurogenesis-is-it-the-alpha-and-omega-of-antidepressant-action
#17
REVIEW
Hoda Eliwa, Catherine Belzung, Alexandre Surget
It is now well established that all clinically available antidepressants share a common aptitude: they increase the production of adult-generated neurons in the dentate gyrus of the hippocampus. This was first observed in animal models and subsequently in human populations, highlighting the clinical relevance of this finding. Later, it was suggested that hippocampal neurogenesis was not an epiphenomenal correlate of antidepressant action but was causally involved. Indeed, when neurogenesis is suppressed, antidepressant compounds can no longer achieve remission...
August 8, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28780167/emotion-related-brain-structures-associated-with-trait-creativity-in-middle-children
#18
Yunman Xia, Kaixiang Zhuang, Jiangzhou Sun, Qunlin Chen, Dongtao Wei, Wenjing Yang, Jiang Qiu
Middle childhood is an important period for individual trait shaping, during which children are likely to generate and own their distinct neuromechanism of creative-related traits. This study used voxel-based morphometry (VBM) to identify the brain structures that underlie trait creativity (as measured by the Williams Creativity Aptitude Test) in a sample of typical developing children (aged 9-12, n=64). The results indicated that several emotion-related regions may relate to trait creativity in middle children...
August 2, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28759707/relevance-of-cystatin-c-n-acetylglucosaminidase-and-interleukin-18-with-the-diagnosis-of-acute-kidney-injury-induced-by-cadmium-in-rats
#19
Ola Sayed Mohamed Ali, Shereen Saeid Elshaer, Hend Mohamed Anwar, Mamdouh Salah El-Din Zohni
The diagnosis of acute kidney injury (AKI) is frequently established on modifications in serum creatinine (SCr). The discriminative and prognostic aptitudes of serum cystatin-C as well as N-acetylglucosaminidase (NAG) and Interleukin-18 (IL-18) were inspected for the estimation of AKI. In this study twelve rats were alienated into two groups: control group received saline, second group received cadmium chloride at a dose (2.4 mg Cd/kg/day, i.p) for 30 days. Blood urea nitrogen (BUN), SCr, and IL-18 serum level were measured in addition to serum and tissue content of cystatin-C and NAG...
July 31, 2017: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/28748196/developing-interactive-antimicrobial-stewardship-and-infection-prevention-curricula-for-diverse-learners-a-tailored-approach
#20
Priya Nori, Theresa Madaline, Iona Munjal, Shubha Bhar, Yi Guo, Susan K Seo, Andrea Porrovecchio, Elizabeth Gancher, Joshua Nosanchuk, Liise-Anne Pirofski, Belinda Ostrowsky
BACKGROUND: To impart principles of antimicrobial stewardship (AS) and infection prevention and control (IPC), we developed a curriculum tailored to the diverse aptitudes of learners at our medical center. METHODS: We integrated case-based modules, group learning activities, smartphone applications (apps), decision support tools, and prescription audit and feedback into curricula of the medical school, medicine residency program, infectious diseases (ID) fellowship program, and hospital medicine program operations...
2017: Open Forum Infectious Diseases
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