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https://www.readbyqxmd.com/read/28632057/rotation-sequence-to-report-humerothoracic-kinematics-during-3d-motion-involving-large-horizontal-component-application-to-the-tennis-forehand-drive
#1
Thomas Creveaux, Violaine Sevrez, Raphaël Dumas, Laurence Chèze, Isabelle Rogowski
The aim of this study was to examine the respective aptitudes of three rotation sequences (YtXf'Yh'', ZtXf'Yh'', and XtZf'Yh'') to effectively describe the orientation of the humerus relative to the thorax during a movement involving a large horizontal abduction/adduction component: the tennis forehand drive. An optoelectronic system was used to record the movements of eight elite male players, each performing ten forehand drives. The occurrences of gimbal lock, phase angle discontinuity and incoherency in the time course of the three angles defining humerothoracic rotation were examined for each rotation sequence...
February 28, 2017: Sports Biomechanics
https://www.readbyqxmd.com/read/28624230/the-correlation-between-fundamental-characteristics-and-first-time-performance-in-laparoscopic-tasks
#2
Cuan M Harrington, Richard Bresler, Donncha Ryan, Patrick Dicker, Oscar Traynor, Dara O Kavanagh
BACKGROUND: The ability of characteristics to predict first time performance in laparoscopic tasks is not well described. Videogame experience predicts positive performance in laparoscopic experiences but its mechanism and confounding-association with aptitude remains to be elucidated. This study sought to evaluate for innate predictors of laparoscopic performance in surgically naive individuals with minimal videogame exposure. METHODS: Participants with no prior laparoscopic exposure and minimal videogaming experience were recruited consecutively from preclinical years at a medical university...
June 8, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28624216/gold-nanoparticles-for-bcr-abl1-gene-silencing-improving-tyrosine-kinase-inhibitor-efficacy-in-chronic-myeloid-leukemia
#3
Raquel Vinhas, Alexandra R Fernandes, Pedro V Baptista
Introduction of tyrosine kinase inhibitors for chronic myeloid leukemia treatment is associated with a 63% probability of maintaining a complete cytogenetic response, meaning that over 30% patients require an alternative methodology to overcome resistance, tolerance, or side effects. Considering the potential of nanotechnology in cancer treatment and the benefits of a combined therapy with imatinib, a nanoconjugate was designed to achieve BCR-ABL1 gene silencing. Gold nanoparticles were functionalized with a single-stranded DNA oligonucleotide that selectively targets the e14a2 BCR-ABL1 transcript expressed by K562 cells...
June 16, 2017: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/28615084/community-wide-stable-isotope-analysis-reveals-two-distinct-trophic-groups-in-a-service-providing-carabid-community
#4
S Kamenova, C Leroux, S E Polin, M Plantegenest
Disentangling trophic interactions among species is important for elucidating mechanisms underlying ecosystem functioning and services. Carabid beetles are an important guild of predators that may regulate pest populations in arable landscapes, but their generalist feeding behavior hinders predictions about their actual contribution to pest control. In order to assess carabids' potential for pest control, we simultaneously analyzed the carbon and nitrogen stable isotope ratios of a community of 45 co-occurring species in wheat and oilseed rape fields...
June 15, 2017: Bulletin of Entomological Research
https://www.readbyqxmd.com/read/28614293/histone-deacetylase-3-prepares-brown-adipose-tissue-for-acute-thermogenic-challenge
#5
Matthew J Emmett, Hee-Woong Lim, Jennifer Jager, Hannah J Richter, Marine Adlanmerini, Lindsey C Peed, Erika R Briggs, David J Steger, Tao Ma, Carrie A Sims, Joseph A Baur, Liming Pei, Kyoung-Jae Won, Patrick Seale, Zachary Gerhart-Hines, Mitchell A Lazar
Brown adipose tissue is a thermogenic organ that dissipates chemical energy as heat to protect animals against hypothermia and to counteract metabolic disease. However, the transcriptional mechanisms that determine the thermogenic capacity of brown adipose tissue before environmental cold are unknown. Here we show that histone deacetylase 3 (HDAC3) is required to activate brown adipose tissue enhancers to ensure thermogenic aptitude. Mice with brown adipose tissue-specific genetic ablation of HDAC3 become severely hypothermic and succumb to acute cold exposure...
June 14, 2017: Nature
https://www.readbyqxmd.com/read/28595593/specialty-preferences-among-medical-students-in-botswana
#6
Ambrose Rukewe, W A Abebe, A A Fatiregun, M Kgantshang
BACKGROUND: With the establishment of a new medical college in Botswana to train generalist-doctors and specialists, we set out to explore the career preferences of medical students, factors that influence their choices and attitude to local postgraduate training. METHODS: A descriptive cross-sectional questionnaire-based study was conducted among medical students in their third to fifth year, at the Faculty of Medicine, University of Botswana. The structured, self-administered questionnaires which were hand-delivered covered demographic characteristics of responders, career choices, preferred location of specialisation and factors that influenced the choices...
June 8, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28584286/genome-wide-meta-analysis-of-cognitive-empathy-heritability-and-correlates-with-sex-neuropsychiatric-conditions-and-cognition
#7
V Warrier, K L Grasby, F Uzefovsky, R Toro, P Smith, B Chakrabarti, J Khadake, E Mawbey-Adamson, N Litterman, J-J Hottenga, G Lubke, D I Boomsma, N G Martin, P K Hatemi, S E Medland, D A Hinds, T Bourgeron, S Baron-Cohen
We conducted a genome-wide meta-analysis of cognitive empathy using the 'Reading the Mind in the Eyes' Test (Eyes Test) in 88,056 research volunteers of European Ancestry (44,574 females and 43,482 males) from 23andMe Inc., and an additional 1497 research volunteers of European Ancestry (891 females and 606 males) from the Brisbane Longitudinal Twin Study. We confirmed a female advantage on the Eyes Test (Cohen's d=0.21, P<2.2 × 10(-16)), and identified a locus in 3p26.1 that is associated with scores on the Eyes Test in females (rs7641347, Pmeta=1...
June 6, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28579322/er-membrane-phospholipids-and-surface-tension-control-cellular-lipid-droplet-formation
#8
Kalthoum Ben M'barek, Dalila Ajjaji, Aymeric Chorlay, Stefano Vanni, Lionel Forêt, Abdou Rachid Thiam
Cells convert excess energy into neutral lipids that are made in the endoplasmic reticulum (ER) bilayer. The lipids are then packaged into spherical or budded lipid droplets (LDs) covered by a phospholipid monolayer containing proteins. LDs play a key role in cellular energy metabolism and homeostasis. A key unanswered question in the life of LDs is how they bud off from the ER. Here, we tackle this question by studying the budding of artificial LDs from model membranes. We find that the bilayer phospholipid composition and surface tension are key parameters of LD budding...
June 19, 2017: Developmental Cell
https://www.readbyqxmd.com/read/28578375/knowledge-aptitudes-and-preferences-in-implant-dentistry-teaching-training-among-undergraduate-dental-students-at-the-university-of-barcelona
#9
M-A Sánchez-Garcés, E Berástegui-Jimeno, C Gay-Escoda
BACKGROUND: Oral implant rehabilitation should be considered a treatment option for any edentulous patient and Implant Dentistry is currently a discipline taught in the undergraduate formation. The level of knowledge acquired and how the students perceive the quality of training in Implant Dentistry could assess to know if it is necessary to improve the syllabus. MATERIAL AND METHODS: A questionnaire was developed with 11 questions: Basic knowledge (7); Perception of training received (2); Ways in which students would receive training (2)...
June 4, 2017: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/28567593/the-social-aptitudes-scale-looking-at-both-ends-of-the-social-functioning-dimension
#10
Luiza Kvitko Axelrud, Diogo Araújo DeSousa, Gisele Gus Manfro, Pedro Mario Pan, Ana Cláudia Knackfuss, Jair de Jesus Mari, Eurípedes Constantino Miguel, Luis Augusto Rohde, Giovanni Abrahão Salum
PURPOSE: Dimensional approaches are likely to advance understanding of human behaviors and emotions. Nevertheless, it is unclear whether instruments in psychiatry capture variability at the full spectrum of these dimensions. We aimed to investigate this issue for two scales assessing distinct aspects of social functioning: the Social Aptitudes Scale (SAS), a "bidirectional" scale constructed to investigate both "ends" of social functioning; and the social Child Behavior Checklist (CBCL-social), a "unidirectional" scale constructed to assess social problems...
May 31, 2017: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/28545613/self-efficacy-in-prosthetics-orthotics-students-who-did-and-did-not-participate-in-short-term-study-abroad-programs-preliminary-results
#11
Goeran Fiedler, Uta Kremer
It is conventional knowledge that travel is educational and that a study stay in a foreign country contributes to a student's personality formation and well-roundedness. The benefit of such experiences on attitudes that shape professional aptitude and career success may, however, be debated. It could be argued that exposure to experiences that are irrelevant to a student's chosen profession may have no sizeable impact - thus not justifying the invested time and money - or, in an extreme case, may even be detrimental to career success if the wrong conclusions are drawn...
April 2017: Zeitschrift Für Evidenz, Fortbildung und Qualität Im Gesundheitswesen
https://www.readbyqxmd.com/read/28537811/aptitude-mother-s-day-winter-beach
#12
Gregory A Abel
No abstract text is available yet for this article.
May 24, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28533183/dedicated-research-time-during-surgery-residency-leads-to-a-significant-decline-in-self-assessed-clinical-aptitude-and-surgical-skills
#13
Monica M Grova, Anthony D Yang, Misty D Humphries, Joseph M Galante, Edgardo S Salcedo
OBJECTIVE: The surgical community commonly perceives a decline in surgical and patient care skills among residents who take dedicated time away from clinical activity to engage in research. We hypothesize that residents perceive a decline in their skills because of dedicated research time. SETTING: UC Davis Medical Center, Sacramento, CA, an institutional tertiary care center. PARTICIPANTS: General surgery residents and graduates from UC Davis general surgery residency training program, who had completed at least 1 year of research during their training...
May 19, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/28520272/a-focus-on-polarity-investigating-the-role-of-orientation-cues-in-mediating-student-performance-on-mrna-synthesis-tasks-in-an-introductory-cell-and-molecular-biology-course
#14
Jeffrey T Olimpo, Daniel A Quijas, Anita M Quintana
The central dogma has served as a foundational model for information flow, exchange, and storage in the biological sciences for several decades. Despite its continued importance, however, recent research suggests that novices in the domain possess several misconceptions regarding the aforementioned processes, including those pertaining specifically to the formation of messenger ribonucleic acid (mRNA) transcripts. In the present study, we sought to expand upon these observations through exploration of the influence of orientation cues on students' aptitude at synthesizing mRNAs from provided deoxyribonucleic acid (DNA) template strands...
May 18, 2017: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/28514897/biomaterials-and-bioactive-agents-in-spinal-fusion
#15
Rui M Duarte, Pedro Varanda, Rui L Reis, Ana Rita C Duarte, Jorge Correia-Pinto
Management of degenerative spine pathologies frequently leads to the need for spinal fusion, where bone growth is induced towards stabilization of the interventioned spine. Autologous bone graft (ABG) remains the gold standard inducer, while new bone graft substitutes attempt to achieve effective de novo bone formation and solid fusion. Limited fusion outcomes have driven motivation for more sophisticated and multidisciplinary solutions, involving new biomaterials and/or biologics, through innovative delivery platforms...
May 17, 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/28507738/mark-e-josephson-clinical-investigator
#16
EDITORIAL
John M Miller
Mark E Josephson entered the world of clinical cardiac electrophysiology (EP) almost at its inception (1972); with so much to learn and so many directions one could take, he dived into the field with unbridled enthusiasm and an uncommon - perhaps almost unique - aptitude for asking questions and finding ways to answer them. Few aspects of EP escaped his indelible influence. In this short paper, I will attempt to touch on some of the high points of his astounding career as a clinical investigator.
April 2017: Arrhythmia & Electrophysiology Review
https://www.readbyqxmd.com/read/28487664/engagement-persistence-and-gender-in-computer-science-results-of-a-smartphone-esm-study
#17
Carolina Milesi, Lara Perez-Felkner, Kevin Brown, Barbara Schneider
While the underrepresentation of women in the fast-growing STEM field of computer science (CS) has been much studied, no consensus exists on the key factors influencing this widening gender gap. Possible suspects include gender differences in aptitude, interest, and academic environment. Our study contributes to this literature by applying student engagement research to study the experiences of college students studying CS, to assess the degree to which differences in men and women's engagement may help account for gender inequity in the field...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28484409/studying-irony-detection-beyond-ironic-criticism-let-s-include-ironic-praise
#18
Richard Bruntsch, Willibald Ruch
Studies of irony detection have commonly used ironic criticisms (i.e., mock positive evaluation of negative circumstances) as stimulus materials. Another basic type of verbal irony, ironic praise (i.e., mock negative evaluation of positive circumstances) is largely absent from studies on individuals' aptitude to detect verbal irony. However, it can be argued that ironic praise needs to be considered in order to investigate the detection of irony in the variety of its facets. To explore whether the detection ironic praise has a benefit beyond ironic criticism, three studies were conducted...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28457682/-quality-of-life-measures-in-sle-an-update
#19
H Devilliers, N Vernier, G Muller, A Turcu, M Samson, P Bielefeld, J-F Besancenot
Systemic lupus erythematosus (SLE) is a chronic disease that considerably hampers patient's daily living. Qualitative studies with patients' interviews have been conducted to describe the experiences and perspectives of adults living with SLE. Among existing generic and disease-specific quality of life (QOL) questionnaires, none succeeded to exhaustively measure patient's preoccupations. However, these tools are useful to quantify the burden of the disease. Social precariousness, socioeconomic status and education level are intimately correlated to QOL measures, either generic or disease-specific...
April 27, 2017: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/28439565/shared-temporoparietal-dysfunction-in-dyslexia-and-typical-readers-with-discrepantly-high-iq
#20
Roeland Hancock, John D E Gabrieli, Fumiko Hoeft
It is currently believed that reading disability (RD) should be defined by reading level without regard to broader aptitude (IQ). There is debate, however, about how to classify individuals who read in the typical range but less well than would be expected by their higher IQ. We used functional magnetic resonance imaging (fMRI) in 49 children to examine whether those with typical, but discrepantly low reading ability relative to IQ, show dyslexia-like activation patterns during reading. Children who were typical readers with high-IQ discrepancy showed reduced activation in left temporoparietal neocortex relative to two control groups of typical readers without IQ discrepancy...
December 2016: Trends in Neuroscience and Education
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