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Alla Bezhentseva, Harpreet Singh, Randy J Boudrieau
OBJECTIVE:  This article describes corrective antebrachiocarpal re-alignment and arthrodesis for bilateral radial hemimelia (radial agenesis) in an 8-month-old domestic short-haired cat. METHODS:  Bilateral forelimb deformity of ulnocarpal varus with complete luxation and rotation of the antebrachiocarpal joint spaces, and joint contracture, was observed. Several carpal bones and metacarpal bones I and II and their associated phalanges were absent. Abnormal ambulation and weight bearing on the dorsolateral part of the manus were present...
June 20, 2018: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
Tyler Keeley, Shengchen Lin, Daniel K Lester, Eric K Lau, Shengyu Yang
The fucose salvage pathway is a two-step process in which mammalian cells transform L-fucose into GDP-L-fucose, a universal fucose donor used by fucosyltransferases to modify glycans. Emerging evidence indicates the fucose salvage pathway and the fucosylation of proteins are altered during melanoma progression and metastasis. However the underlying mechanisms are not completely understood. Here, we report that the fucose salvage pathway inhibits invadopodia formation and extracellular matrix degradation by promoting α-1,2 fucosylation...
2018: PloS One
R E Kalinin, I A Suchkov, R V Deev, N D Mzhavanadze, A A Krylov
Analysed in the article are the results of a comprehensive approach to treatment of patients presenting with lower limb critical ischaemia and diabetes mellitus by means of gene-induced angiogenesis. The study comprised a total of 65 patients found to have an ill-suited for surgical reconstruction peripheral arterial bed and undergoing conservative therapy. The patients were divided into two groups. The Study Group patients additionally to the conventional conservative therapy received 2 intramuscular injections of therapeutic agent Neovasculgen at a course dose of 2...
2018: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
Takamasa Kayama, Shinya Sato, Kaori Sakurada, Junki Mizusawa, Ryo Nishikawa, Yoshitaka Narita, Minako Sumi, Yasuji Miyakita, Toshihiro Kumabe, Yukihiko Sonoda, Yoshiki Arakawa, Susumu Miyamoto, Takaaki Beppu, Kazuhiko Sugiyama, Hirohiko Nakamura, Motoo Nagane, Yoko Nakasu, Naoya Hashimoto, Mizuhiko Terasaki, Akira Matsumura, Eiichi Ishikawa, Toshihiko Wakabayashi, Yasuo Iwadate, Shiro Ohue, Hiroyuki Kobayashi, Manabu Kinoshita, Kenichiro Asano, Akitake Mukasa, Katsuyuki Tanaka, Akio Asai, Hideo Nakamura, Tatsuya Abe, Yoshihiro Muragaki, Koichi Iwasaki, Tomokazu Aoki, Takao Watanabe, Hikaru Sasaki, Shuichi Izumoto, Masahiro Mizoguchi, Takayuki Matsuo, Hideo Takeshima, Motohiro Hayashi, Hidefumi Jokura, Takashi Mizowaki, Eiji Shimizu, Hiroki Shirato, Masao Tago, Hiroshi Katayama, Haruhiko Fukuda, Soichiro Shibui
Purpose Whereas whole-brain radiotherapy (WBRT) has been the standard treatment of brain metastases (BMs), stereotactic radiosurgery (SRS) is increasingly preferred to avoid cognitive dysfunction; however, it has not been clearly determined whether treatment with SRS is as effective as that with WBRT or WBRT plus SRS. We thus assessed the noninferiority of salvage SRS to WBRT in patients with BMs. Patients and Methods Patients age 20 to 79 years old with performance status scores of 0 to 2-and 3 if caused only by neurologic deficits-and with four or fewer surgically resected BMs with only one lesion > 3 cm in diameter were eligible...
June 20, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Rebecca Kern, Jill Cannoy
No abstract text is available yet for this article.
July 2018: Pediatric Physical Therapy
Saori Braun, Kristie Bjornson, Erin Dillon-Naftolin, Melissa Sheiko, Kit Song, Minsoo Kang
PURPOSE: The study purpose was to determine the minimum number of monitoring days necessary to reliably capture walking among individuals with lower limb salvage. METHODS: Nineteen participants with lower limb salvage wore an ankle-mounted motion sensor over a 7-day period to obtain step counts. Generalizability theory was used to examine the variance components in step counts (G study) and to determine the appropriate length of activity monitoring using various combinations of days (D study)...
July 2018: Pediatric Physical Therapy
Gerardo Rosati, Nunzio Del Gaudio, Enrico Scarano, Rosa Anna Cifarelli, Lucia Altucci, Domenico Bilancia
RATIONALE: Regorafenib is an oral multikinase inhibitor and is approved as salvage therapy in the standard treatment of advanced colorectal cancer (CRC). Due to its limited efficacy, toxicity profile, and cost, it is necessary to identify those patients who may have the most benefit from regorafenib. In a previous case report, kinase insert domain receptor (KDR) mutation has been associated with exceptional clinical response (CR) in an elderly patient treated with a low dose of regorafenib; thus, it was hypothesized that it could represent a new predictive marker of drug response...
June 2018: Medicine (Baltimore)
Xiaodong Sun, Zhongqi Fan, Wei Qiu, Yuguo Chen, Chao Jiang, Guoyue Lv
RATIONALE: Median arcuate ligament (MAL) may compress the coeliac trunk inducing median arcuate ligament syndrome (MALS). MALS is a risk factor for hepatic artery thrombosis (HAT) in liver transplant recipients. PATIENT CONCERNS: A thin female complained about upper abdominal pain for two months. DIAGNOSES: The patient was diagnosed as primary biliary cirrhosis. INTERVENTIONS: The patient received two liver transplantations...
June 2018: Medicine (Baltimore)
April C Cockcroft, Alexey M Markelov
Background: Trapeziectomy with interpositional arthroplasty using Repriza acellular dermal matrix is a novel technique to treat primary and secondary carpometacarpal joint arthritis. Early studies with nonautograft interposition indicate promising post-trapeziectomy space maintenance with results similar to ligament reconstruction with tendon interposition, without the potential risks and increased operating time of harvesting a tendon autograft. Methods: Eleven patients in a retrospective cohort were followed for a minimum of 6 weeks (mean, 12)...
May 2018: Plastic and Reconstructive Surgery. Global Open
Alonso A Lopez-Zavala, Eduardo Guevara-Hernandez, Luz H Vazquez-Lujan, Arturo Sanchez-Paz, Karina D Garcia-Orozco, Carmen A Contreras-Vergara, Gamaliel Lopez-Leal, Aldo A Arvizu-Flores, Adrian Ochoa-Leyva, Rogerio R Sotelo-Mundo
Thymidylate synthase (TS, E.C. is a crucial enzyme for de novo deoxythymidine monophosphate (dTMP) biosynthesis. The gene for this enzyme is thyA , which encodes the folate-dependent TS that converts deoxyuridine monophosphate group (dUMP) into (dTMP) using the cofactor 5,10-methylenetetrahydrofolate (mTHF) as a carbon donor. We identified the thyA gene in the genome of the Vibrio parahaemolyticus strain FIM-S1708+ that is innocuous to humans but pathogenic to crustaceans. Surprisingly, we found changes in the residues that bind the substrate dUMP and mTHF, previously postulated as invariant among all TSs known (Finer-Moore, Santi & Stroud, 2003)...
2018: PeerJ
Qin Tong, Shuming Ouyang, Lingling Feng, Hanyu Wang, Yunfei Xia, Yujing Zhang
Background: This study aims to retrospectively analyze the salvage treatment outcomes and prognostic factors of patients with early stage locoregionally recurrent (LRR) extranodal natural killer (NK)/T-cell lymphoma, nasal type (ENKTCL). Methods: Between January 1995 and December 2014, 540 patients with stage IE-IIE ENKTCL received chemotherapy (ChT) and/or radiotherapy (RT) in our hospital, and among these, 56 patients who experienced LRR were included in this study...
2018: Therapeutics and Clinical Risk Management
Anthony P Y Liu, Pamela P W Lee, Janette S Y Kwok, Rock Y Y Leung, Alan K S Chiang, Shau-Yin Ha, Daniel K L Cheuk, Godfrey C F Chan
Relapsed/refractory NB carries a bleak outcome, warranting novel treatment options. HaploHSCT induces a graft-versus-NB effect via natural killer cell alloreactivity. Review of patients with relapsed/refractory NB who underwent haploHSCT with ex vivo T-cell depletion in our unit from 2013 through 2018. Ten patients were identified (male=5; median age at haploHSCT=6.45 y, range: 3.49-11.02 y). Indications were relapsed in 7 and refractoriness in 3; disease status at haploHSCT was CR in 2, PR in 6, and PD in 2...
June 19, 2018: Pediatric Transplantation
Ramon Sanchez-Ocana, Irene Penas-Herrero, Paula Gil-Simon, Carlos de la Serna-Higuera, Manuel Perez-Miranda
No abstract text is available yet for this article.
December 2017: VideoGIE: an official video journal of the American Society for Gastrointestinal Endoscopy
Helle D Zacho, Julie B Nielsen, Katja Dettmann, Uwe Haberkorn, Niels C Langkilde, Jørgen B Jensen, Lars J Petersen
PURPOSE OF THE REPORT: The aim of this study was to prospectively investigate the detection rate of Ga-PSMA PET/CT in biochemical recurrence (BCR) of prostate cancer and its impact on patient management. MATERIALS AND METHODS: Patients with BCR after curatively intended treatment of prostate cancer were included. Each patient underwent a Ga-PSMA PET/CT. Changes in patient management based on the results of Ga-PSMA PET/CT were assessed. RESULTS: Seventy patients were included...
June 19, 2018: Clinical Nuclear Medicine
Hyun Ho Han, Hyung Bae Kim, Eun Key Kim, Jin Sup Eom
BACKGROUND: Immediate single-stage direct-to-implant breast reconstruction requires caution owing to the possibility of skin necrosis and implant failure. Nevertheless, this method has been performed widely for breast reconstruction. This study aimed to analyze the safety of single-stage implant reconstruction by comparing it with 2-stage reconstruction (TSR). METHODS: Immediate single-stage reconstructions (SSRs) and TSRs with a tissue expander, performed from January 2011 to December 2016, were retrospectively reviewed...
June 19, 2018: Annals of Plastic Surgery
Yi-Syuan Li, Chun-Yu Chen, Shan-Wei Yang, Yih-Wen Tarng
Objectives Fingertip amputation is often encountered in emergency departments, especially in hospitals located near industrial areas. Replantation of the fingertip can be considered when the normal architecture is preserved in cases of sharp amputation. The goal of replantation is to preserve cosmesis and function, especially for the thumb because of its involvement in grasping and the key pinch. Even when microsurgical vascular anastomosis is applied, the absence of venous anastomosis along with the high rate of failure of arterial anastomosis in zone 1A fingertip amputation may lead to replantation failure...
January 1, 2018: Journal of International Medical Research
Muhammet Uraloğlu, Murat Livaoğlu, Özgür Agdoğan, Şafak Ersöz, Naci Karaçal
Background/aim: Multiple zones of injuries are formed after burns, consisting of a zone of coagulative necrosis, a zone of hyperemia, and a zone of stasis, in which progressive microcirculatory thrombosis leads to degeneration and deepening of the wound. We used an experimental rat comb burn model to test the hypothesis that use of low molecular weight heparin (LMWH) may save the zone of stasis. Materials and methods: Adult female rats were randomly divided two groups: the LMWH group (n = 8) rats received subcutaneous LMWH injections, while the saline group (n = 8) rats were injected with the same volume of saline solution by the same route...
June 14, 2018: Turkish Journal of Medical Sciences
Hyuk Jae Jung, Soon Chon Lee, Kyung Yun Kim, Sang Su Lee
The purpose of revascularization in lower extremity arterial occlusive disease is to prevent amputation and improve walking ability. Many surgical techniques for peripheral vascular disease (PAD) have been reported. The hybrid operation composed of open surgery and endovascular procedure has been increasingly used for multilevel revascularization. The goal of this study is to evaluate feasibility of simultaneous hybrid femoral endarterectomy and endovascular treatment in patients who need multilevel revascularization with critical limb ischemia...
April 2018: Indian Journal of Surgery
Dean J Arnaoutakis, Gaurav Sharma, Stuart Blackwood, Samir K Shah, Matthew Menard, C Keith Ozaki, Michael Belkin
BACKGROUND: Failure of endovascular aneurysm repairs (EVARs) requiring open conversion remains a major challenge. We analyzed indications for repair, operative strategies, and outcomes with a focus on iliac artery degeneration after endograft removal. METHODS: A prospective, institutional database was reviewed to identify patients who underwent explantation of a failed EVAR device. Demographics, reason for failure, operative details including extent of endograft removal, and complications/survival were examined...
June 15, 2018: Journal of Vascular Surgery
Jie Chen, Jian Hua Wan, Dang Yan Wu, Wen Qing Shu, Liang Xia, Nong Hua Lu
BACKGROUND: It is generally accepted that precut sphincterotomy during endoscopic retrograde cholangiopancreatography (ERCP) increases the risk of pancreatitis. However, patients with difficult biliary access may be different. We implemented a meta-analysis to explore the effects of early and delayed precut sphincterotomy on post-ERCP pancreatitis in patients with difficult biliary access. METHODS: We searched studies in PubMed, EMBASE, and the Cochrane Central Register of Randomized Controlled Trials for meeting requirement in which precut sphincterotomy was compared with persistent standard cannulation during ERCP...
June 16, 2018: Journal of Clinical Gastroenterology
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