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https://www.readbyqxmd.com/read/29453945/evaluation-of-lipid-peroxidation-and-antioxidant-defense-mechanisms-in-the-bone-of-rats-in-conditions-of-separate-and-combined-administration-of-vanadium-v-and-magnesium-mg
#1
Agnieszka Ścibior, Dorota Gołębiowska, Agnieszka Adamczyk, Joanna Kurus, Magdalena Staniszewska, Ilona Sadok
The impact of vanadium (V) and magnesium (Mg) applied as sodium metavanadate (SMV, 0.125 mg V/ml) and magnesium sulfate (MS, 0.06 mg Mg/ml) on oxidative stress markers in bone of male Wistar rats was investigated. Some of them were also measured in the liver, e.g. l-ascorbic acid (hepatic L-AA). Additionally, relationships between selected indices determined in bone were examined. SMV alone (Group II) did not significantly alter the level of TBARS and the activity of SOD, compared with the control (Group I), but it slightly reduced the GR activity (by 13%) and the L-AA level (by 15...
February 14, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29453817/endocrine-and-psychological-aspects-of-sexual-dysfunction-in-klinefelter-patients
#2
A Ferlin, R Selice, S Angelini, M Di Grazia, N Caretta, F Cavalieri, A Di Mambro, C Foresta
Klinefelter syndrome is a frequent cause of hypogonadism, but despite hundreds of publications on different aspects of Klinefelter syndrome, only a few studies dealt with sexual dysfunction. In particular, testosterone is critical for various aspects of sexual response, but its role on sexuality in Klinefelter syndrome patients is debatable and no studies have evaluated the efficacy of testosterone treatment on sexual dysfunction in these subjects. Furthermore, the impact of psychological and relational aspects on sexual function of Klinefelter syndrome subjects is poorly defined...
February 17, 2018: Andrology
https://www.readbyqxmd.com/read/29453534/nanoparticles-caused-oxidative-imbalance
#3
Mariusz Zuberek, Agnieszka Grzelak
Application of nanomaterials in nearly every single branch of industry results in their accumulation in both abiotic environment and tissues of living organisms. Despite the common use of nanomaterials, we are not able to precisely define their toxicity towards humans and surrounding biota. Although we were able to determine final effects of chronic exposure to nanoparticles which consist of many pathologies such as respiratory diseases, allergies, diseases of cardiovascular system, disorders in embryonic life differentiation and growth disorders, toxic effects on the immune system and cancers...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29453509/critical-thresholds-for-eventual-extinction-in-randomly-disturbed-population-growth-models
#4
Scott D Peckham, Edward C Waymire, Patrick De Leenheer
This paper considers several single species growth models featuring a carrying capacity, which are subject to random disturbances that lead to instantaneous population reduction at the disturbance times. This is motivated in part by growing concerns about the impacts of climate change. Our main goal is to understand whether or not the species can persist in the long run. We consider the discrete-time stochastic process obtained by sampling the system immediately after the disturbances, and find various thresholds for several modes of convergence of this discrete process, including thresholds for the absence or existence of a positively supported invariant distribution...
February 16, 2018: Journal of Mathematical Biology
https://www.readbyqxmd.com/read/29453445/alterations-in-interhemispheric-gamma-band-connectivity-are-related-to-the-emergence-of-auditory-verbal-hallucinations-in-healthy-subjects-during-nmda-receptor-blockade
#5
Thiebes Stephanie, Steinmann Saskia, Curic Stjepan, Polomac Nenad, Andreou Christina, Eichler Iris-Carola, Eichler Lars, Zöllner Christian, Gallinat Jürgen, Leicht Gregor, Mulert Christoph
Auditory verbal hallucinations (AVH) are a common positive symptom of schizophrenia. Excitatory-to-inhibitory (E/I) imbalance related to disturbed N-methyl-D-aspartate receptor (NMDAR) functioning has been suggested as a possible mechanism underlying altered connectivity and AVH in schizophrenia. The current study examined the effects of ketamine, a NMDAR antagonist, on glutamate-related mechanisms underlying interhemispheric gamma-band connectivity, conscious auditory perception during dichotic listening (DL), and the emergence of auditory verbal distortions and hallucinations (AVD/AVH) in healthy volunteers...
February 5, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29453118/effects-of-forest-regeneration-practices-on-the-flux-of-soil-co-2-after-clear-cutting-in-subtropical-china
#6
Yixiang Wang, Xudan Zhu, Shangbin Bai, Tingting Zhu, Wanting Qiu, Yujie You, Minjuan Wu, Frank Berninger, Zhibin Sun, Hui Zhang, Xiaohong Zhang
Reforestation after clear-cutting is used to facilitate rapid establishment of new stands. However, reforestation may cause additional soil disturbance by affecting soil temperature and moisture, thus potentially influencing soil respiration. Our aim was to compare the effects of different reforestation methods on soil CO 2 flux after clear-cutting in a Chinese fir plantation in subtropical China: uncut (UC), clear-cut followed by coppicing regeneration without soil preparation (CC), clear-cut followed by coppicing regeneration and reforestation with soil preparation, tending in pits and replanting (CCR P ), and clear-cut followed by coppicing regeneration and reforestation with overall soil preparation, tending and replanting (CCR O )...
February 13, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29452983/orchestration-of-nlrp3-inflammasome-activation-by-ion-fluxes
#7
REVIEW
Tao Gong, Yanqing Yang, Tengchuan Jin, Wei Jiang, Rongbin Zhou
The assembly of the NLRP3 inflammasome can promote the release of IL-1β/IL-18 and initiate pyroptosis. Accordingly, the dysregulation of NLRP3 inflammasome activation is involved in a variety of human diseases, including gout, diabetes, and Alzheimer's disease. NLRP3 can sense a variety of structurally unrelated pathogen-associated molecular patterns (PAMPs) or danger-associated molecular patterns (DAMPs) to trigger inflammation, but the unifying mechanism of NLRP3 activation is still poorly understood. Increasing evidence suggests that intracellular ions, such as K + , Ca 2+ , and Cl - , have a significant role in NLRP3 inflammasome activation...
February 13, 2018: Trends in Immunology
https://www.readbyqxmd.com/read/29452801/systematic-review-of-the-effects-of-intensive-care-unit-noise-on-sleep-of-healthy-subjects-and-the-critically-ill
#8
REVIEW
S Horsten, L Reinke, A R Absalom, J E Tulleken
Intensive-care-unit (ICU) patients exhibit disturbed sleeping patterns, often attributed to environmental noise, although the relative contribution of noise compared to other potentially disrupting factors is often debated. We therefore systematically reviewed studies of the effects of ICU noise on the quality of sleep to determine to what extent noise explains the observed sleep disruption, using the Cochrane Collaboration method for non-randomized studies. Searches in Scopus, PubMed, Embase, CINAHL, Web of Science, and the Cochrane Library were conducted until May 2017...
March 2018: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29452675/dbs-for-parkinson-s-disease-with-behavioural-disturbances
#9
Angelo Antonini, Jose A Obeso
No abstract text is available yet for this article.
March 2018: Lancet Neurology
https://www.readbyqxmd.com/read/29452400/sleep-quality-in-well-defined-lyme-disease-a-clinical-cohort-study-in-maryland
#10
Eric R Weinstein, Alison W Rebman, John N Aucott, Doug Johnson-Greene, Kathleen T Bechtold
Study Objectives: Lyme disease (LD) is the most common vector-borne disease in the United States. Approximately 5-15% of patients develop post-antibiotic treatment symptoms termed post-treatment LD syndrome (PTLDS). The primary objective of this study was to examine and quantify sleep quality among patients with early Lyme disease during the acute and convalescent periods, including among the subset who met criteria for PTLDS. Methods: This paper draws from a clinical cohort study of early LD participants (n=122) and a sub-cohort of individuals who later met criteria for PTLDS (n=6)...
February 14, 2018: Sleep
https://www.readbyqxmd.com/read/29452205/impaired-cerebral-microcirculation-induced-by-ammonium-chloride-in-rats-is-due-to-cortical-adenosine-release
#11
Peter Nissen Bjerring, Esben Jannik Bjerrum, Fin Stolze Larsen
BACKGROUND: Liver failure results in hyperammonaemia, impaired regulation of cerebral microcirculation, encephalopathy and death. However, the key mediator that alters cerebral microcirculation remains unidentified. In this study we show that topical ammonium significantly increases periarteriolar adenosine tone on the brain surface of healthy rats and is associated with a disturbed microcirculation. METHODS: Cranial windows were prepared in anaesthetized Wistar rats...
February 13, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/29452128/are-sleep-disturbances-causally-linked-to-the-presence-and-severity-of-psychotic-like-dissociative-and-hypomanic-experiences-in-non-clinical-populations-a-systematic-review
#12
REVIEW
Jack Barton, Simon D Kyle, Filippo Varese, Steven H Jones, Gillian Haddock
The present review aimed to 1) identify what sleep disturbances co-occur alongside psychotic-like, dissociative and hypomanic experiences; 2) assess the strength of potential associations between the severity of sleep disturbances and of the experiences studied; and 3) appraise evidence for a causal link. MedLine and PsycInfo were searched and 44 studies were deemed eligible. Results showed that insomnia was associated with all individual psychotic-like, dissociative and hypomanic experiences reviewed (effect size range: small-to-large)...
February 13, 2018: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29451956/posttraumatic-stress-disorder-ptsd-and-complex-ptsd-cptsd-as-per-icd-11-proposals-a-population-study-in-israel
#13
Menachem Ben-Ezra, Thanos Karatzias, Philip Hyland, Chris R Brewin, Marylene Cloitre, Jonathan I Bisson, Neil P Roberts, Brigitte Lueger-Schuster, Mark Shevlin
BACKGROUND: The current study sought to advance the existing literature by providing the first assessment of the factorial and discriminant validity of the ICD-11 proposals for posttraumatic stress disorder (PTSD) and complex PTSD (CPTSD) in a nationwide level. METHODS: A nationally representative sample from Israel (n = 1,003) using a disorder-specific measure (ITQ; International Trauma Questionnaire) in order to assess PTSD and CPTSD along with the Life Events Checklist and the World Health Organization Well-Being Index...
February 16, 2018: Depression and Anxiety
https://www.readbyqxmd.com/read/29451892/assessing-site-formation-and-assemblage-integrity-through-stone-tool-refitting-at-gruta-da-oliveira-almonda-karst-system-torres-novas-portugal-a-middle-paleolithic-case-study
#14
Marianne Deschamps, João Zilhão
We use stone tool refitting to assess palimpsest formation and stratigraphic integrity in the basal units of the Gruta da Oliveira archeo-stratigraphic sequence, layers 15-27, which TL and U-series dating places in late Marine Isotope Stage (MIS) 5 or early MIS 4. As in most karst contexts, the formation of this succession involved multiple and complex phenomena, including subsidence, bioturbation, carnivore activity and runoff as agents of potential post-depositional disturbance. During phases of stabilization, such as represented by layers 15, 21 and 22, the excavated area was inhabited and refits corroborate that post-depositional displacement is negligible...
2018: PloS One
https://www.readbyqxmd.com/read/29451818/overexpression-of-heart-specific-small-subunit-of-myosin-light-chain-phosphatase-results-in-heart-failure-and-conduction-disturbance
#15
Takuro Arimura, Antoine Muchir, Masayoshi Kuwahara, Sachio Morimoto, Taisuke Ishikawa, Cheng-Kun Du, Dong-Yun Zhan, Shu Nakao, Noboru Machida, Ryo Tanaka, Yoshihisa Yamane, Takeharu Hayashi, Akinori Kimura
Mutations in genes encoding components of sarcomere cause cardiomyopathy, which is often associated with abnormal Ca 2+ sensitivity of muscle contraction. We previously showed that a heart-specific myosin light chain phosphatase small subunit, hHS-M 21 , increases the Ca 2+ -sensitivity of muscle contraction. The aim of this study was to investigate the function of hHS-M 21 in vivo and the causative role of abnormal Ca 2+ sensitivity in cardiomyopathy. We generated transgenic (Tg) mice with cardiac-specific overexpression of hHS-M 21 ...
February 16, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29451455/laser-ablative-therapy-of-sessile-hypothalamic-hamartomas-in-children-using-interventional-mri-report-of-5-cases
#16
Derek G Southwell, Harjus S Birk, Paul S Larson, Philip A Starr, Leo P Sugrue, Kurtis I Auguste
Hypothalamic hamartomas (HHs) are benign lesions that cause medically refractory seizures, behavioral disturbances, and endocrine dysfunction. Open resection of HHs does not guarantee seizure freedom and carries a relatively high risk of morbidity. Minimally invasive stereotactic laser ablation has recently been described as an effective and safe alternative for HH treatment. Prior studies have not, however, assessed HH lesion size and morphology, 2 factors that may influence treatment results and, ultimately, the generalizability of their findings...
February 16, 2018: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29451300/decreased-anterior-cingulate-activation-in-a-motor-task-in-youths-with-bipolar-disorder
#17
Jace B King, Jeffrey S Anderson, Deborah A Yurgelun-Todd, Punitha Subramaniam, Marie R Ehrler, Melissa P Lopez-Larson
BACKGROUND: Bipolar disorder (BP) is characterized by abnormal shifts in mood between episodes of mania and severe depression, both of which have been linked with psychomotor disturbances. This study compares brain activation patterns in motor networks between euthymic youths with BP and healthy controls (HC) during the completion of a simple motor task. METHODS: Thirty-five youths with BP and 35 HC (aged 10-19) completed a self-paced sequential bilateral finger-tapping task, consisting of a 4-minute scan block with alternating 20-second periods of either the tapping task (six blocks) or rest (six blocks), while undergoing functional magnetic resonance imaging...
February 16, 2018: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/29451297/enhancement-of-the-conductivity-detection-signal-in-capillary-electrophoresis-systems-using-neutral-cyclodextrins-as-sweeping-agents
#18
Milan Boublík, Martina Riesová, Pavel Dubský, Bohuslav Gaš
Conductivity detection is a universal detection technique often encountered in electrophoretic separation systems, especially in modern chip-electrophoresis based devices. On the other hand, it is sparsely combined with another contemporary trend of enhancing limits of detection by means of various preconcentration strategies. This can be attributed to the fact that a preconcentration experimental setup usually brings about disturbances in a conductivity baseline. Sweeping with a neutral sweeping agent seems a good candidate for overcoming this problem...
February 16, 2018: Electrophoresis
https://www.readbyqxmd.com/read/29451224/hypogonadism-in-male-thalassemia-major-patients-pathophysiology-diagnosis-and-treatment
#19
Vincenzo De Sanctis, Ashraf T Soliman, Mohamed A Yassin, Salvatore Di Maio, Shahina Daar, Heba Elsedfy, Nada Soliman, Christos Kattamis
Failure of pubertal growth, delay or absence of sexual development, infertility and sexual dysfunction due to hypogonadism and defective spermatogenesis are frequent and well recognized disturbances among male patients with transfusion dependent (TD) thalassaemia major (β-thal). These problems are attributed mainly to the damage caused by chronic anaemia and the deposition of excess iron in the pituitary gland and testicles. This is a short review of male pubertal disorders in patients with β-thal written by pediatric endocrinologists and haematologists with an interest and active involvement, in the diagnosis and management of these complications in this group of patients...
February 16, 2018: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/29451074/negative-emotional-face-perception-is-diminished-on-a-very-early-level-of-processing-in-autism-spectrum-disorder
#20
Alexander Prehn-Kristensen, Anna Lorenzen, Fabian Grabe, Lioba Baving
Deficits in facial affect recognition (FAR) are often reported in autism spectrum disorders (ASD) due to inappropriate visual search strategies. It is unclear, however, whether or not deficits in subliminal FAR are still present in autism when visual focus is controlled. Thirteen persons with ASD and 13 healthy participants took part in this experiment. Supraliminal FAR was assessed using a standardized, computer-aided test. Subliminal FAR was obtained by an emotional face priming paradigm. By using an eye-tracking technique, it was assured that the initial visual focus was on the eyes of the prime...
February 16, 2018: Social Neuroscience
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