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https://www.readbyqxmd.com/read/29929197/sleep-disordered-breathing-in-children-with-rare-skeletal-disorders-a-survey-of-clinical-records
#1
Marco Zaffanello, Giorgio Piacentini, Luca Sacchetto, Angelo Pietrobelli, Emma Gasperi, Marco Barillari, Nicolò Cardobi, Luana Nosetti, Diego Ramaroli, Franco Antoniazzi
OBJECTIVE: Craniofacial disharmony in skeletal diseases is strongly associated with sleep-disordered breathing. Our aim was to study sleep respiratory patterns in young children with rare skeletal disorders. DESIGN: This retrospective study included children with achondroplasia, osteogenesis imperfecta and Ellis van Creveld Syndrome. Our subjects underwent an in-laboratory overnight respiratory polygraph between January 2012 and April 2016. All medical records were reviewed and brain Magnetic Resonance Imaging was conducted on patients with achondroplasia, nasopharynx, oropharynx and laryngopharynx spaces...
June 21, 2018: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/29929189/dexmedetomidine-protects-neural-stem-cells-from-ketamine-induced-injury
#2
Pan Lu, Shan Lei, Weisong Li, Yang Lu, Juan Zheng, Ning Wang, Yongjun Xia, Haixia Lu, Xinlin Chen, Yong Liu, Peng-Bo Zhang
BACKGROUND/AIMS: Ketamine inhibits the proliferation of neural stem cells (NSCs) and disturbs normal neurogenesis. Dexmedetomidine provides neuroprotection against volatile anesthetic-induced neuroapoptosis and cognitive impairment in the developing brain. Whether it may protect NSCs from ketamine-induced injury remains unknown. In this study, we investigated the protective effects of dexmedetomidine on ketamine-exposed NSCs and explored the mechanisms potentially involved. METHODS: Primary NSC cultures were characterized using immunofluorescence...
June 19, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29929142/persisting-responses-of-salt-marsh-fungal-communities-to-the-deepwater-horizon-oil-spill
#3
Candice Y Lumibao, Stephen Formel, Vijaikrishnah Elango, John H Pardue, Michael Blum, Sunshine A Van Bael
The plant microbiome, composed of diverse interacting microorganisms, is thought to undergird host integrity and well-being. Though it is well understood that environmental perturbations like oil pollution can alter the diversity and composition of microbiomes, remarkably little is known about how disturbance alters plant-fungal associations. Using Next-Generation sequencing of the 18S rDNA internal transcribed spacer (ITS1) region, we examined outcomes of enduring oil exposure on aboveground leaf and belowground endophytic root and rhizosphere fungal communities of Spartina alterniflora, a highly valued ecosystem engineer in southeastern Louisiana marshes affected by the 2010 Deepwater Horizon accident...
June 18, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29929033/central-herniation-induced-by-craniotomy-prompting-air-replacement-for-subdural-fluid-collection-due-to-cerebrospinal-fluid-hypovolemia-a-case-report
#4
Takahide Haku, Yasushi Motoyama, Yoshiaki Takamura, Shuichi Yamada, Ichiro Nakagawa, Young-Su Park, Hiroyuki Nakase
BACKGROUND: Chronic subdural hematoma (CSDH) often occurs in association with cerebrospinal fluid (CSF) hypovolemia. Many cases with CSDH due to CSF hypovolemia and treated by burr-hole surgery have been reported to present with paradoxical deterioration. However, the mechanisms and pathology of deterioration after surgery for CSDH due to CSF hypovolemia remain obscure. CASE DESCRIPTION: We report herein a 62-year-old man with gait disturbance due to subdural fluid collection (SDFC) who underwent burr-hole irrigation and additional craniotomy, in which postoperative deterioration resulted from rapidly progressing central herniation with large amount of air accumulation...
June 18, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29929027/percutaneous-pedicle-screw-fixation-with-bone-cement-augmentation-under-epidural-anesthesia-for-the-treatment-of-k%C3%A3-mmell-s-disease-at-extremely-old-age-a-case-report
#5
Keun Lee, Nitin Adsul, Hyeun-Sung Kim, Yong-Hun Pee, Kwang Lae Lee, Il-Tae Jang
BACKGROUND: In cases of Kümmell's disease without neuro deficit, percutaneous vertebroplasty or Kyphoplasty have achieved short-term favorable outcomes. In the long term, re-collapse of the augmented vertebral body and aggravation of the kyphosis at the index level is often reported. On the other hand, owing to medical comorbidities, the elderly are often not suited for extensive open spine surgery under general anesthesia. CASE DESCRIPTION: A 95-year-old man presented with a one-month history of intractable back pain and gait disturbance...
June 18, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29928918/combined-exposure-to-carbon-disulfide-and-low-frequency-noise-reversibly-affects-vestibular-function
#6
Monique Chalansonnet, Maria Carreres-Pons, Thomas Venet, Aurélie Thomas, Lise Merlen, Carole Seidel, Frédéric Cosnier, Hervé Nunge, Benoît Pouyatos, Jordi Llorens, Pierre Campo
Chronic occupational exposure to carbon disulfide (CS2) has debilitating motor and sensory effects in humans, which can increase the risk of falls. Although no mention of vestibulotoxic effects is contained in the literature, epidemiological and experimental data suggest that CS2 could cause low-frequency hearing loss when associated with noise exposure. Low-frequency noise might also perturb the peripheral balance receptor through an as-yet unclear mechanism. Here, we studied how exposure to a low-frequency noise combined with 250-ppm CS2 affected balance in rats...
June 18, 2018: Neurotoxicology
https://www.readbyqxmd.com/read/29928886/chronic-sleep-restriction-increases-pain-sensitivity-over-time-in-a-periaqueductal-gray-and-nucleus-accumbens-dependent-manner
#7
Natalia Fantin Sardi, Mayla Ketlyn Lazzarim, Vinicius Augusto Guilhen, Renata Scuzziatto Marcílio, Priscila Shizue Natume, Thainá Caldeiras Watanabe, Marcelo de Meira Santos Lima, Glaucia Tobaldini, Luana Fischer
Painful conditions and sleep disturbances are major public health problems worldwide and one directly affects the other. Sleep loss increases pain prevalence and severity; while pain disturbs sleep. However, the underlying mechanisms are largely unknown. Here we asked whether chronic sleep restriction for 6 h daily progressively increases pain sensitivity and if this increase is reversed after two days of free sleep. Also, whether the pronociceptive effect of chronic sleep restriction depends on the periaqueductal grey and on the nucleus accumbens, two key regions involved in the modulation of pain and sleep-wake cycle...
June 18, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29928764/inhomogeneous-down-regulation-of-i-na-underlies-piceatannol-pro-arrhythmic-mechanism-in-regional-ischemia-reperfusion
#8
Po-Cheng Chang, Yu-Chang Huang, Hui-Ling Lee, Gwo-Jyh Chang, Yen Chu, Ming-Shien Wen, Chung-Chuan Chou
BACKGROUND: Piceatannol, a grape-derived polyphenol, has been linked to pro-arrhythmic properties by aggravating inhomogeneous conduction delay in the ischemia-reperfusion (IR) zone to enhance arrhythmogenic alternans in heart failure (HF) rabbits. The underlying molecular mechanisms of piceatannol-induced conduction disturbance were unclear in this model. METHODS: HF was induced by 4-weeks rapid ventricular pacing. IR injury was induced in vivo using a protocol of left coronary artery ligation and release...
June 21, 2018: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29928703/evaluating-the-prevalence-and-predictive-factors-of-vasomotor-and-psychological-symptoms-in-prostate-cancer-patients-receiving-hormonal-therapy-results-from-a-single-institution-experience
#9
Amarnath Challapalli, Steve M Edwards, Paul Abel, Stephen A Mangar
Background & purpose: The impact of vasomotor symptoms (VMS) occurring in prostate cancer (PC) patients whilst on androgen deprivation therapy (ADT) has not been extensively researched. This longitudinal study sought to assess the VMS and identify any predictive factors. Material & methods: Data from 250 PC patients on ADT were prospectively evaluated between January 10 and August 13 using a physician-directed questionnaire, to assess the impact of VMS. Parameters including height, weight, body surface area (BSA), body mass index (BMI), duration/type of ADT, co-morbidities and ethnicity were recorded...
March 2018: Clinical and Translational Radiation Oncology
https://www.readbyqxmd.com/read/29928596/predictive-timing-disturbance-is-a-precise-marker-of-schizophrenia
#10
Valentina Ciullo, Federica Piras, Daniela Vecchio, Nerisa Banaj, Jennifer T Coull, Gianfranco Spalletta
Timing disturbances have being proposed as a key component of schizophrenia pathogenesis. However, the contribution of cognitive impairment to such disorders has not been clarified. Here, we investigated duration estimation and predictive timing in 30 patients with DSM-5 diagnosis of schizophrenia (SZ) compared to 30 healthy controls (HC). Duration estimation was examined in a temporal and colour discrimination task, fully controlled for working memory (WM) and attention requirements, and by more traditional temporal production and temporal bisection tasks...
June 2018: Schizophrenia Research. Cognition
https://www.readbyqxmd.com/read/29928520/can-muscle-protein-metabolism-be-specifically-targeted-by-nutritional-support-and-exercise-training-in-chronic-obstructive-pulmonary-disease
#11
REVIEW
Ramzi Lakhdar, Roberto A Rabinovich
Chronic obstructive pulmonary disease (COPD) associates with several extra-pulmonary effects. Muscle dysfunction and wasting is one of the most prominent extra-pulmonary effects and contributes to exercise limitation and health related quality of life (HRQoL), morbidity as well as mortality. The loss of muscle mass is characterised by an impaired balance between protein synthesis (anabolism) and protein breakdown (catabolism) which relates to nutritional disturbances, muscle disuse and the presence of a systemic inflammation, among other factors...
May 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29928451/an-exceptional-presentation-of-pituicytoma-apoplexy-a-case-report
#12
Giulia Cossu, Julien Dimitriou, Jean-Philippe Brouland, Roy Thomas Daniel, Mahmoud Messerer
Pituicytomas are a rare form of indolent neoplasms, which typically present with visual disturbance and hypopituitarism. Complete resection by a trans-sphenoidal approach is the optimal treatment. Only 80 cases have been described thus far in the current literature and the present case is the first to describe the development of pituitary apoplexy in the context of a pituicytoma. A 77-year-old man presented with fatigue and clinical signs of hypogonadism and a sellar lesion was diagnosed at cerebral magnetic resonance imaging (MRI)...
July 2018: Oncology Letters
https://www.readbyqxmd.com/read/29928449/primary-cauda-equina-lymphoma-diagnosed-by-nerve-biopsy-a-case-report-and-literature-review
#13
Kayo Suzuki, Taketoshi Yasuda, Toshihito Hiraiwa, Masahiko Kanamori, Tomoatsu Kimura, Yoshiharu Kawaguchi
Primary cauda equina lymphoma (CEL) is a rare malignant tumor among various neoplasms that affects the cauda equina nerve roots. The present case report described the case of a 65-year-old man who presented with cauda equina syndrome with progressive motor palsy in the legs and gait disturbance over the last 5 months. Magnetic resonance (MR) images showed enlargement of the cauda equina occupying the dural sac from the L1-S1 level with isointensity to the spinal cord signal on both T1- and T2-weighted imaging...
July 2018: Oncology Letters
https://www.readbyqxmd.com/read/29928395/proprotein-convertase-subtilisin-kexin-type-6-activates-the-extracellular-signal-regulated-kinase-1-2-and-wnt-family-member-3a-pathways-and-promotes-in-vitro-proliferation-migration-and-invasion-of-breast-cancer-mda-mb-231-cells
#14
Ping Wang, Feifei Wang, Lin Wang, Jihong Pan
Breast cancer progression results from the acquisition of genetic and epigenetic alterations that promote tumor cell proliferation and survival. Proprotein convertase subtilisin/kexin type 6 (PCSK6) is a proteinase that regulates the proteolytic activity of various precursor proteins as well as protein maturation. PCSK6 also influences cancer cell proliferation, invasion and migration. Therefore, to investigate the effects of PCSK6 in breast cancer, human breast cancer MDA-MB-231 cells were treated with recombinant human PCSK6 in vitro ...
July 2018: Oncology Letters
https://www.readbyqxmd.com/read/29928383/research-progress-on-common-adverse-events-caused-by-targeted-therapy-for-colorectal-cancer
#15
REVIEW
Bo Zhang, Chenyan Fang, Dehou Deng, Liang Xia
As targeted drug therapy is increasingly applied in the treatment of colon cancer, understanding and managing the adverse reactions of patients is becoming increasingly important. The present review examines the mechanisms of and adverse reactions to the most commonly used targeted drugs for colon cancer, and discusses methods of coping with these adverse reactions. Approved targeted drugs for metastatic colon cancer include monoclonal antibodies targeting vascular endothelial growth factor (VEGF), including bevacizumab, ziv-aflibercept and regorafenib, and monoclonal antibodies targeting epithelial growth factor receptor (EGFR), including cetuximab and panitumumab...
July 2018: Oncology Letters
https://www.readbyqxmd.com/read/29928218/severe-acute-axonal-neuropathy-induced-by-ciprofloxacin-a-case-report
#16
Cyprian Popescu
Fluoroquinolones increase the risk of peripheral neuropathy. The present work aims to report a case of fluoroquinolone-related severe axonal neuropathy. The subject of this study was a 62-year-old man who exhibited generalized sensory disturbances 4 days after treatment by ciprofloxacin prescribed for urinary infection. Electrodiagnostic studies revealed severe motor-sensory axonal neuropathy with widespread fibrillation potentials in support of generalized motor polyradiculopathy. There was no evidence of conduction blocks or albuminocytologic dissociation in favor of an autoimmune inflammatory reaction...
May 2018: Case Reports in Neurology
https://www.readbyqxmd.com/read/29928186/hypothermia-related-acute-pancreatitis
#17
Kyawzaw Lin, Emmanuel Ofori, Aung Naing Lin, Sithu Lin, Thinzar Lin, Ameer Rasheed, Viswanath Vasudevan, Madhavi Reddy
Acute pancreatitis (AP) is an inflammatory disease presenting from mild localized inflammation to severe infected necrotic pancreatic tissue. In the literature, there are a few cases of hypothermia-induced AP. However, the association between hypothermia and AP is still a myth. Generally, mortality from acute pancreatitis is nearly 3-6%. Here, we present a 40-year-old chronic alcoholic female who presented with acute pancreatitis induced by transient hypothermia. A 40-year-old chronic alcoholic female was hypothermic at 81°F on arrival which was improved to 91...
May 2018: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/29927894/body-weight-and-mood-state-modifications-in-mixed-martial-arts-an-exploratory-pilot
#18
Ricardo Brandt, Guilherme G Bevilacqua, Danilo R Coimbra, Luiz C Pombo, Bianca Miarka, Andrew M Lane
Brandt, R, Bevilacqua, GG, Coimbra, DR, Pombo, LC, Miarka, B, and Lane, AM. Body weight and mood state modifications in mixed martial arts: An exploratory pilot. J Strength Cond Res XX(X): 000-000, 2018-Mixed martial arts (MMA) fighters typically use rapid weight loss (RWL) as a strategy to make competition weight. The aim of the present study was to compare body weight and mood changes in professional male MMA athletes who used strategies to rapidly lose weight (n = 9) and with MMA athletes who did not (n = 3)...
June 20, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29927875/depressed-physical-performance-outlasts-hormonal-disturbances-after-military-training
#19
Håvard Hamarsland, Gøran Paulsen, Paul A Solberg, Ole Gunnar Slaathaug, Truls Raastad
INTRODUCTION: The aim of this study was to investigate the effect of an arduous one-week military course on measures of physical performance, body composition and blood biomarkers. METHODS: Participants were apprentices in an annual selection course for the Norwegian Special Forces. Fifteen soldiers (23±4 yrs., 1.81±0.06 m, 78±7 kg) completed a hell-week consisting of rigorous activity only interspersed by 2-3 hours of sleep per day. Testing was conducted before and 0, 1, 3, 7 and 14 days after the hell-week...
June 21, 2018: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29927659/limitations-in-the-prediction-of-mass-violence-cautionary-tales
#20
Robert P Archer
The incidents of mass violence that have occurred in the United States have been deeply disturbing to the public as well as to mental health professionals. The public, the media, as well as our patients, family members, and friends have reached out to mental health professionals in the hope that we can provide an understanding of these events that might serve to reduce their frequency in the future. This article explores how we can best respond to these requests, including the current limitations of psychologists in the prediction of mass violence...
June 21, 2018: Journal of Personality Assessment
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