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https://www.readbyqxmd.com/read/29447437/j-shaped-association-between-post-operative-levothyroxine-dosage-and-fracture-risk-in-thyroid-cancer-patients-a-retrospective-cohort-study
#1
Dong Wook Shin, Beomseok Suh, Hyunsun Lim, Jae Moon Yun, Sun Ok Song, Youngmin Park
Long-term administration of supraphysiologic dosages of levothyroxine can have detrimental effect on the bone. We aimed to investigate fracture incidence among post-thyroidectomy thyroid cancer patients compared with matched comparison group, and explore the association between levothyroxine dosage and fracture risk. From the Korean National Health Insurance database, virtually all thyroid cancer patients who received thyroidectomy in Korea from January 1, 2004 to December 31, 2012 were included. Matched subjects were selected by 1:1 propensity score matching...
February 15, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29446077/coffee-drinking-and-colorectal-cancer-and-its-subsites-a-pooled-analysis-of-8-cohort-studies-in-japan
#2
Ikuko Kashino, Shamima Akter, Tetsuya Mizoue, Norie Sawada, Ayaka Kotemori, Keitaro Matsuo, Isao Oze, Hidemi Ito, Mariko Naito, Tomio Nakayama, Yuri Kitamura, Akiko Tamakoshi, Ichiro Tsuji, Yumi Sugawara, Manami Inoue, Chisato Nagata, Atsuko Sadakane, Keitaro Tanaka, Shoichiro Tsugane, Taichi Shimazu
Coffee is a rich source of bioactive compounds that have potential anti-carcinogenic effects. However, it remains unclear whether coffee drinking is associated with colorectal cancer. Also, despite different etiological factors involved in gut physiology, few studies have investigated this association by anatomical site of the lesion. To address these issues, this study examined the association between coffee drinking and colorectal cancer in a pooled analysis from 8 cohort studies conducted in Japan. Among 320,322 participants followed up for 4,503,276 person-years, 6,711 incident colorectal cancer cases were identified...
February 15, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29444207/the-functional-network-signature-of-heterogeneity-in-freezing-of-gait
#3
Kaylena A Ehgoetz Martens, Julie M Hall, Matthew J Georgiades, Moran Gilat, Courtney C Walton, Elie Matar, Simon J G Lewis, James M Shine
Freezing of gait is a complex, heterogeneous, and highly variable phenomenon whose pathophysiology and neural signature remains enigmatic. Evidence suggests that freezing is associated with impairments across cognitive, motor and affective domains; however, most research to date has focused on investigating one axis of freezing of gait in isolation. This has led to inconsistent findings and a range of different pathophysiological models of freezing of gait, due in large part to the tendency for studies to investigate freezing of gait as a homogeneous entity...
February 9, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29440761/intimate-partner-violence-correlates-with-a-higher-hiv-incidence-among-msm-a-12-month-prospective-cohort-study-in-shenyang-china
#4
Hong-Yi Wang, Ning Wang, Zhen-Xing Chu, Jing Zhang, Xiang Mao, Wen-Qing Geng, Yong-Jun Jiang, Hong Shang, Jun-Jie Xu
Intimate partner violence (IPV) and HIV are highly prevalent worldwide among MSM. However, the association between IPV and HIV seroconversion is virtually unknown. This 12-month prospective cohort study was conducted among MSM in Shenyang, China to explore the causality between IPV and the incidence of HIV. Adjusted Hazard Ratios (aHRs) of HIV acquisition were derived from a multivariate time-dependent Cox model and applied to calculate population attributable fractions (PAFs). Among 476 HIV-negative MSM subjects, 89(18...
February 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29427550/clinically-relevant-discrepancies-between-different-rheumatoid-factor-assays
#5
Willem J J Falkenburg, Helen J von Richthofen, Jana Koers, Cas Weykamp, Marco W J Schreurs, Liesbeth E Bakker-Jonges, Inez-Anne Haagen, Willem F Lems, Dörte Hamann, Dirkjan van Schaardenburg, Theo Rispens
BACKGROUND: Accurate measurements of rheumatoid factors (RFs), autoantibodies binding IgG, are important for diagnosing rheumatoid arthritis (RA) and for predicting disease course. Worldwide, various RF assays are being used that differ in technique and target antigens. We studied whether assay choice leads to clinically important discrepancies in RF status and level. METHODS: RF measurements using four commercial RF assays were compared in 32 RF+ samples. Using enzyme-linked immunosorbent assays (ELISAs), the influence of the target antigen source - human IgG (hIgG) versus rabbit IgG (rIgG) - on measured RF levels was investigated in arthralgia patients and RA patients...
February 10, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29424675/intradural-spinal-arachnoid-cyst-resection-implications-of-duraplasty-in-a-large-case-series
#6
Ziev B Moses, Gabriel N Friedman, David L Penn, Isaac H Solomon, John H Chi
OBJECTIVE Optimal diagnosis and management strategies for intradural spinal arachnoid cysts (SACs) are still unresolved given the rare nature of this entity, with few large case series and virtually no statistical analyses of patient characteristics in the literature. Here, the authors studied a large patient cohort with these lesions to determine whether pre- or postoperative attributes could be used to aid in either diagnosis or prognosis. METHODS A chart review was completed at a single institution for the period from 2002 to 2016 to determine the preoperative characteristics and postoperative outcomes of 21 patients with exclusively intradural SACs...
February 9, 2018: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29401334/financial-and-temporal-advantages-of-virtual-consultation-in-veterans-requiring-specialty-care
#7
Daniel E Abbott, Ryan A Macke, Jodi Kurtz, Nasia Safdar, Caprice C Greenberg, Sharon M Weber, Corrine I Voils, Deborah A Fisher, James D Maloney
Background: Access to specialty health care in the Veterans Affairs (VA) system continues to be problematic. Given the potential temporal and fiscal benefits of telehealth, the Madison VA developed a virtual consultation (VC) mechanism to expedite diagnostic and therapeutic interventions for Veterans with incidentally discovered pulmonary nodules. Materials and. Methods: VC, a remote encounter between referring provider and thoracic surgeon for incidentally discovered pulmonary nodules, was implemented at the Madison VA between 2009 and 2011...
January 1, 2018: Military Medicine
https://www.readbyqxmd.com/read/29394918/expanded-hiv-pre-exposure-prophylaxis-prep-implementation-in-communities-in-new-south-wales-australia-epic-nsw-design-of-an-open-label-single-arm-implementation-trial
#8
Iryna B Zablotska, Christine Selvey, Rebecca Guy, Karen Price, Jo Holden, Heather-Marie Schmidt, Anna McNulty, David Smith, Fengyi Jin, Janaki Amin, David A Cooper, Andrew E Grulich
BACKGROUND: The New South Wales (NSW) HIV Strategy 2016-2020 aims for the virtual elimination of HIV transmission in NSW, Australia, by 2020. Despite high and increasing levels of HIV testing and treatment since 2012, the annual number of HIV diagnoses in NSW has remained generally unchanged. Pre-exposure prophylaxis (PrEP) is highly effective in preventing HIV infection among gay and bisexual men (GBM) when taken appropriately. However, there have been no population-level studies that evaluate the impact of rapid PrEP scale-up in high-risk GBM...
February 2, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29365340/towards-implementation-of-omop-in-a-german-university-hospital-consortium
#9
C Maier, L Lang, H Storf, P Vormstein, R Bieber, J Bernarding, T Herrmann, C Haverkamp, P Horki, J Laufer, F Berger, G Höning, H W Fritsch, J Schüttler, T Ganslandt, H U Prokosch, M Sedlmayr
BACKGROUND:  In 2015, the German Federal Ministry of Education and Research initiated a large data integration and data sharing research initiative to improve the reuse of data from patient care and translational research. The Observational Medical Outcomes Partnership (OMOP) common data model and the Observational Health Data Sciences and Informatics (OHDSI) tools could be used as a core element in this initiative for harmonizing the terminologies used as well as facilitating the federation of research analyses across institutions...
January 2018: Applied Clinical Informatics
https://www.readbyqxmd.com/read/29355977/helicobacter-pylori-infection-is-associated-with-favorable-outcome-in-advanced-gastric-cancer-patients-treated-with-s-1-adjuvant-chemotherapy
#10
Satoshi S Nishizuka, Gen Tamura, Masahiro Nakatochi, Norimasa Fukushima, Yukimi Ohmori, Chihiro Sumida, Takeshi Iwaya, Takashi Takahashi, Keisuke Koeda
BACKGROUND AND OBJECTIVES: Limited information exists regarding beneficial effects of Helicobacter pylori. To examine the effect in advanced gastric cancer, we compared survival for patients treated with surgery-only or adjuvant chemotherapy on the basis of H. pylori infection status. METHODS: A cohort of 491 patients who underwent R0 resection for locally advanced gastric cancer between 2000 and 2009 at 12 institutions in northern Japan was included. H. pylori infection status, was assessed from paraffin-embedded formalin-fixed samples...
January 22, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29352674/the-effect-of-vertical-split-flow-patient-management-on-emergency-department-throughput-and-efficiency
#11
John S Garrett, Colyn Berry, Hao Wong, Huanying Qin, Jeffery A Kline
BACKGROUND: To address emergency department overcrowding operational research seeks to identify efficient processes to optimize flow of patients through the emergency department. Vertical flow refers to the concept of utilizing and assigning patients virtual beds rather than to an actual physical space within the emergency department to care of low acuity patients. The aim of this study is to evaluate the impact of vertical flow upon emergency department efficiency and patient satisfaction...
January 11, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29349543/saving-robots-improves-laparoscopic-performance-transfer-of-skills-from-a-serious-game-to-a-virtual-reality-simulator
#12
Wouter M IJgosse, Harry van Goor, Jan-Maarten Luursema
BACKGROUND: Residents find it hard to commit to structural laparoscopic skills training. Serious gaming has been proposed as a solution on the premise that it is effective and more motivating than traditional simulation. We establish construct validity for the laparoscopic serious game Underground by comparing laparoscopic simulator performance for a control group and an Underground training group. METHODS: A four-session laparoscopic basic skills course is part of the medical master students surgical internship at the Radboud University Medical Centre...
January 18, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29348623/fetal-vitamin-d-concentration-and-growth-adiposity-and-neurodevelopment-during-infancy
#13
H Wang, X D Yu, L S Huang, Q Chen, F X Ouyang, X Wang, J Zhang
BACKGROUND/OBJECTIVES: To determine the association between cord blood 25-hydroxyvitamin D (25(OH)D) concentration with growth, adiposity and neurodevelopment during infancy. SUBJECTS/METHODS: Serum 25(OH)D was measured in cord blood by the liquid chromatography tandem mass spectrometry (LC-MS/MS) from the Shanghai's "Allergy and Obesity Cohort study" (n = 1244). Weight, length, head circumference, and body mass index (BMI) z-scores for age were calculated based on World Health Organization Standard (at 6 months, 1 years, and 2 years)...
January 18, 2018: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29344295/peptide-receptor-radionuclide-therapy-as-a-new-tool-in-treatment-refractory-sarcoidosis-initial-experience-in-two-patients
#14
Constantin Lapa, Malte Kircher, Heribert Hänscheid, Andreas Schirbel, Götz Ulrich Grigoleit, Erdwine Klinker, Markus Böck, Samuel Samnick, Theo Pelzer, Andreas K Buck
Sarcoidosis is a multisystem granulomatous disorder of unknown etiology that can involve virtually all organ systems. Whereas most patients present without symptoms, progressive and disabling organ failure can occur in up to 10% of subjects. Somatostatin receptor (SSTR)-directed peptide receptor radionuclide therapy (PRRT) has recently received market authorization for treatment of SSTR-positive neuroendocrine tumors. Methods: We describe the first case series comprising two patients with refractory multi-organ involvement of sarcoidosis who received 4 cycles of PRRT...
2018: Theranostics
https://www.readbyqxmd.com/read/29340835/repurposed-fda-approved-drugs-targeting-genes-influencing-aging-can-extend-lifespan-and-healthspan-in-rotifers
#15
Terry W Snell, Rachel K Johnston, Amelia B Matthews, Hongyi Zhou, Mu Gao, Jeffrey Skolnick
Pharmaceutical interventions can slow aging in animals, and have advantages because their dose can be tightly regulated and the timing of the intervention can be closely controlled. They also may complement environmental interventions like caloric restriction by acting additively. A fertile source for therapies slowing aging is FDA approved drugs whose safety has been investigated. Because drugs bind to several protein targets, they cause multiple effects, many of which have not been characterized. It is possible that some of the side effects of drugs prescribed for one therapy may have benefits in retarding aging...
January 16, 2018: Biogerontology
https://www.readbyqxmd.com/read/29338321/are-wishes-for-death-or-suicidal-ideation-symptoms-of-depression-in-older-adults
#16
Rebecca C Rossom, Greg E Simon, Karen J Coleman, Arne Beck, Malia Oliver, Christine Stewart, Brian Ahmedani
OBJECTIVE: Clinicians may question whether thoughts of being better off dead are normal consequences of aging or symptoms of depression. We examine whether thoughts of suicide are as strongly linked to depression severity in older adults as they are in other age groups. METHODS: Cross-sectional cohort study. Participants included 509,945 outpatients >18 years old from four large integrated healthcare systems in the Mental Health Research Network who completed 1...
January 17, 2018: Aging & Mental Health
https://www.readbyqxmd.com/read/29332429/engagement-as-predictors-of-performance-in-a-single-cohort-of-undergraduate-chiropractic-students
#17
Jacqueline Rix, Philip Dewhurst, Caroline Cooke, David Newell
OBJECTIVE: To investigate the potential association of novel academic and nonacademic factors with chiropractic student academic performance. METHODS: Students enrolled into year 1 of a chiropractic master's degree (MChiro) at our college were selected for this study. Data collected included demographics, attendance, virtual learning environment use, additional learning needs, previous degree qualifications, and summative marks. Differences between students who had to take an examination more than once (resit) and nonresit students were explored using t test and χ2 analysis...
January 13, 2018: Journal of Chiropractic Education
https://www.readbyqxmd.com/read/29313124/development-of-a-train-to-proficiency-curriculum-for-the-technical-skills-component-of-the-fundamentals-of-endoscopic-surgery-exam
#18
Susan Gearhart, Michael Marohn, Saowanee Ngamruengphong, Gina Adrales, Oluwafemi Owodunni, Kim Duncan, Emil Petrusa, Pamela Lipsett
BACKGROUND: The demonstration of competency in endoscopy is required prior to obtaining American Board of Surgery Certification. To demonstrate competency, the resident must pass a national high-stakes cognitive test and a technical skills exam on a virtual reality simulator. The purpose of this preliminary study was to design a proficiency-based endoscopy simulation curriculum to meet this competency requirement. METHODS: This is a mixed methods prospective cohort study at a single academic medical institution...
January 8, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29310624/adhd-medication-in-offspring-of-immigrants-does-the-income-level-of-the-country-of-parental-origin-matter
#19
Arzu Arat, Viveca Östberg, Bo Burström, Anders Hjern
BACKGROUND: Child psychiatric treatment facilities vary greatly worldwide and are virtually non-existent in many low-income countries. One of the most common psychiatric disorders in childhood is ADHD, with an estimated prevalence of 3-5% in Sweden. Previous studies have shown a similar prevalence of ADHD in minority and majority children in Sweden and the UK. However, clinical studies demonstrated that children from immigrant families living in Sweden received less psychiatric care than those of native-born parents...
January 8, 2018: BMC Psychiatry
https://www.readbyqxmd.com/read/29305952/yield-and-bias-in-defining-a-cohort-study-baseline-from-electronic-health-record-data
#20
Jason L Vassy, Yuk-Lam Ho, Jacqueline Honerlaw, Kelly Cho, J Michael Gaziano, Peter W F Wilson, David R Gagnon
AIMS: Despite growing interest in using electronic health records (EHR) to create longitudinal cohort studies, the distribution and missingness of EHR data might introduce selection bias and information bias to such analyses. We aimed to examine the yield and potential for these healthcare process biases in defining a study baseline using EHR data, using the example of cholesterol and blood pressure (BP) measurements. METHODS: We created a virtual cohort study of cardiovascular disease (CVD) from patients with eligible cholesterol profiles in the New England (NE) and Southeast (SE) networks of the Veterans Health Administration in the United States...
January 3, 2018: Journal of Biomedical Informatics
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