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https://www.readbyqxmd.com/read/29667471/cost-effectiveness-analysis-of-suvorexant-for-the-treatment-of-japanese-elderly-patients-with-chronic-insnomnia-in-a-virtual-cohort
#1
Shinichi Nishimura, Mutsuhiro Nakao
AIMS: We assessed the cost effectiveness of the orexin receptor antagonist suvorexant against zolpidem, the most widely used hypnotic benzodiazepine receptor agonist in Japan. To this end, a model was used that factored in insomnia and the risk for hip fractures, which have devastating effects on the elderly. METHODS: Data were derived from published papers. The target population was a virtual cohort of elderly patients (≥65 years) with insomnia residing in Japan...
April 18, 2018: Journal of Medical Economics
https://www.readbyqxmd.com/read/29628512/hot-news-sexually-transmitted-infections-on-the-rise-in-prep-users
#2
Pablo Barreiro
Pre-exposure prophylaxis (PrEP) with oral Truvada (tenofovir plus emtricitabine) is effective at preventing HIV infection in high-risk homosexual men. In the United States, PrEP was approved in 2012 and is reimbursed by Medicaid and the majority of private insurers. The situation is diverse and not uniform in the European Union, being PrEP more widely used in France than in the rest of countries. Concerns have been raised that PrEP use may be accompanied by the phenomena of risk compensation or behavioral disinhibition, whereby PrEP users' perception of decreased risk of HIV acquisition may lead them to engage in overall riskier sexual practices and increase their chances of acquiring sexually transmitted infections (STIs) (Blumenthal, et al...
January 2018: AIDS Reviews
https://www.readbyqxmd.com/read/29626260/clinical-utility-of-pharmacogenetic-testing-in-children-and-adolescents-with-severe-mental-disorders
#3
Hilario Blasco-Fontecilla
This is a retrospective cohort study of 20 children and adolescents to evaluate the clinical utility of a pharmacogenetic decision support tool. Twenty children and adolescents underwent pharmacogenetic testing between June 2014 and May 2017. All children and adolescents were evaluated at Puerta de Hierro University Hospital-Majadahonda (Madrid, Spain). We report the proportion of patients achieving clinical improvement, amelioration of side effects, and changes in number of drugs. Data normality was assessed with the Shapiro-Wilk test, and changes of pre- and post-pharmacogenetic testing were analyzed with the Wilcoxon test for paired samples...
April 6, 2018: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29604264/european-prevention-of-alzheimer-s-dementia-registry-recruitment-and-prescreening-approach-for-a-longitudinal-cohort-and-prevention-trials
#4
Lisa Vermunt, Colin D Veal, Lea Ter Meulen, Charalambos Chrysostomou, Wiesje van der Flier, Giovanni B Frisoni, Idris Guessous, Miia Kivipelto, Moira Marizzoni, Pablo Martinez-Lage, José Luis Molinuevo, David Porteus, Karen Ritchie, Philip Scheltens, Pierre-Jean Ousset, Craig W Ritchie, Gerald Luscan, Anthony J Brookes, Pieter Jelle Visser
BACKGROUND: It is a challenge to find participants for Alzheimer's disease (AD) prevention trials within a short period of time. The European Prevention of Alzheimer's Dementia Registry aims to facilitate recruitment by preselecting subjects from ongoing cohort studies. This article introduces this novel approach. METHODS: A virtual registry, with access to risk factors and biomarkers for AD through minimal data sets of ongoing cohort studies, was set up. RESULTS: To date, ten cohorts have been included in the European Prevention of Alzheimer's Dementia Registry...
March 28, 2018: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/29603918/the-effect-of-age-on-cancer-specific-mortality-in-patients-with-small-renal-masses-a-population-based-analysis
#5
Marco Bandini, Michele Marchioni, Raisa S Pompe, Zhe Tian, Tristan Martel, Felix K Chun, Luca Cindolo, Anil Kapoor, Francesco Montorsi, Shahrokh F Shariat, Alberto Briganti, Pierre I Karakiewicz
INTRODUCTION: Contemporary data regarding the effect of age, especially in the elderly patients, on cancer-specific mortality (CSM) for pT1a renal cell cancer (RCC) are lacking. The objective of the current study is to evaluate CSM in a large population-based cohort of surgically treated pT1a RCC patients according to age groups. METHODS: Within the Surveillance Epidemiology and End Results database (2000-2013), we identified 37 121 pT1a RCC patients who underwent either partial or radical nephrectomy...
March 19, 2018: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/29595812/rapid-prenatal-diagnosis-using-targeted-exome-sequencing-a-cohort-study-to-assess-feasibility-and-potential-impact-on-prenatal-counseling-and-pregnancy-management
#6
Natalie Chandler, Sunayna Best, Jane Hayward, Francesca Faravelli, Sahar Mansour, Emma Kivuva, Dagmar Tapon, Alison Male, Catherine DeVile, Lyn S Chitty
PurposeUnexpected fetal abnormalities occur in 2-5% of pregnancies. While traditional cytogenetic and microarray approaches achieve diagnosis in around 40% of cases, lack of diagnosis in others impedes parental counseling, informed decision making, and pregnancy management. Postnatally exome sequencing yields high diagnostic rates, but relies on careful phenotyping to interpret genotype results. Here we used a multidisciplinary approach to explore the utility of rapid fetal exome sequencing for prenatal diagnosis using skeletal dysplasias as an exemplar...
March 29, 2018: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/29584523/brain-behavior-mechanisms-for-the-transfer-of-neuromuscular-training-adaptions-to-simulated-sport-initial-findings-from-the-train-the-brain-project
#7
Dustin R Grooms, Adam W Kiefer, Michael A Riley, Jonathan D Ellis, Staci Thomas, Katie Kitchen, Christopher DiCesare, Scott Bonnette, Brooke Gadd, Kim D Barber Foss, Weihong Yuan, Paula Silva, Ryan Galloway, Jed Diekfuss, James Leach, Kate Berz, Gregory D Myer
CONTEXT: A limiting factor for reducing anterior cruciate ligament (ACL) injury risk is ensuring that the movement adaptions made during the prevention program transfer to sport-specific activity. Virtual reality provides a mechanism to assess transferability and neuroimaging provides a means to assay the neural processes allowing for such skill transfer. OBJECTIVE: To determine the neural mechanisms for injury risk reducing biomechanics transfer to sport after ACL injury prevention training...
March 27, 2018: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/29554234/a-computational-analysis-of-different-endograft-designs-for-zone-0-aortic-arch-repair
#8
Theodorus M van Bakel, Christopher J Arthurs, Joost A van Herwaarden, Frans L Moll, Kim A Eagle, Himanshu J Patel, Santi Trimarchi, C Alberto Figueroa
OBJECTIVES: Aortic arch repair remains a major surgical challenge. Multiple manufacturers are developing branched endografts for Zone 0 endovascular repair, extending the armamentarium for minimally invasive treatment of aortic arch pathologies. We hypothesize that the design of the Zone 0 endograft has a significant impact on the postoperative haemodynamic performance, particularly in the cervical arteries. The goal of our study was to compare the postoperative haemodynamic performance of different Zone 0 endograft designs...
March 15, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29553555/an-objective-and-child-friendly-assessment-of-arm-function-by-using-a-3-d-sensor
#9
Xing Chen, Detlef Wolf, Juliane Siebourg-Polster, Christian Czech, Ulrike Bonati, Dirk Fischer, Omar Khwaja, Martin Strahm
Progressive and irreversible muscle atrophy characterizes Spinal Muscular Atrophy (SMA) and other similar muscle disorder diseases. Objective assessment of muscle functions is an essential and important, although challenging, prerequisite for successful clinical trials. Current clinical rating scales restrain the movement abnormalities to certain predefined coarse-grained individual items. The Kinect 3-D sensor has emerged as a low-cost and portable motion sensing technology used to capture and track people's movement in many medical and research fields...
February 12, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29549202/can-virtual-autopsy-with-postmortem-ct-improve-clinical-diagnosis-of-cause-of-death-a-retrospective-observational-cohort-study-in-a-dutch-tertiary-referral-centre
#10
Lianne J P Sonnemans, Bela Kubat, Mathias Prokop, Willemijn M Klein
OBJECTIVE: To investigate whether virtual autopsy with postmortem CT (PMCT) improves clinical diagnosis of the immediate cause of death. DESIGN: Retrospective observational cohort study. INCLUSION CRITERIA: inhospital and out-of-hospital deaths over the age of 1 year in whom virtual autopsy with PMCT and conventional autopsy were performed. EXCLUSION CRITERIA: forensic cases, postmortal organ donors and cases with incomplete scanning procedures...
March 16, 2018: BMJ Open
https://www.readbyqxmd.com/read/29548061/the-role-of-virtual-rehabilitation-in-total-and-unicompartmental-knee-arthroplasty
#11
Morad Chughtai, John J Kelly, Jared M Newman, Assem A Sultan, Anton Khlopas, Nipun Sodhi, Anil Bhave, Michael C Kolczun, Michael A Mont
This study evaluated the use of telerehabilitation during the postoperative period for patients who underwent total knee arthroplasty (TKA) or unicompartmental knee arthroplasty (UKA). Specifically, this study evaluated the following: (1) patient compliance and adherence to the program, (2) time spent performing physical therapy exercises, (3) the usability of the virtual rehabilitation platform, and (4) clinical outcome scores in a selected primary knee arthroplasty cohort. A total of 157 consecutive patients underwent TKA ( n  = 18) or UKA ( n  = 139)...
March 16, 2018: Journal of Knee Surgery
https://www.readbyqxmd.com/read/29547985/smoking-smoking-cessation-and-the-risk-of-hearing-loss-japan-epidemiology-collaboration-on-occupational-health-study
#12
Huanhuan Hu, Naoko Sasaki, Takayuki Ogasawara, Satsue Nagahama, Shamima Akter, Keisuke Kuwahara, Takeshi Kochi, Masafumi Eguchi, Ikuko Kashino, Taizo Murakami, Makiko Shimizu, Akihiko Uehara, Makoto Yamamoto, Tohru Nakagawa, Toru Honda, Shuichiro Yamamoto, Ai Hori, Chihiro Nishiura, Hiroko Okazaki, Teppei Imai, Akiko Nishihara, Toshiaki Miyamoto, Kentaro Tomita, Isamu Kabe, Tetsuya Mizoue, Naoki Kunugita, Seitaro Dohi
Introduction: We aimed to determine the prospective association of smoking status, smoking intensity, and smoking cessation with the risk of hearing loss in a large Japanese cohort. Methods: The cohort study included 50195 employees, who were aged 20-64 years and free of hearing loss at baseline. Participants were followed up for a maximum of 8 years. Pure-tone audiometric testing was performed annually to identify hearing loss at 1 and 4 kHz. Cox proportional hazards regression models were used to investigate the association between smoking and hearing loss...
March 14, 2018: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/29543944/validation-of-the-colorado-retinopathy-of-prematurity-screening-model
#13
Emily A McCourt, Gui-Shuang Ying, Anne M Lynch, Alan G Palestine, Brandie D Wagner, Erica Wymore, Lauren A Tomlinson, Gil Binenbaum
Importance: The Colorado Retinopathy of Prematurity (CO-ROP) model uses birth weight, gestational age, and weight gain at the first month of life (WG-28) to predict risk of severe retinopathy of prematurity (ROP). In previous validation studies, the model performed very well, predicting virtually all cases of severe ROP and potentially reducing the number of infants who need ROP examinations, warranting validation in a larger, more diverse population. Objective: To validate the performance of the CO-ROP model in a large multicenter cohort...
March 15, 2018: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29541863/distribution-of-innate-psychomotor-skills-recognized-as-important-for-surgical-specialization-in-unconditioned-medical-undergraduates
#14
Andrea Moglia, Luca Morelli, Vincenzo Ferrari, Mauro Ferrari, Franco Mosca, Alfred Cuschieri
BACKGROUND: There is an increasing interest for a test assessing objectively the innate aptitude for surgery as a craft specialty to complement the current selection process of surgical residents. The aim of this study was to quantify the size of individuals with high, average, and low level of innate psychomotor skills among medical students. METHODS: A volunteer sample of 155 medical students, without prior experience with surgical simulator, executed five tasks at a virtual simulator for robot-assisted surgery...
March 14, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29535212/breast-cancer-histologic-grading-using-digital-microscopy-concordance-and-outcome-association
#15
Emad A Rakha, Mohamed Aleskandarani, Michael S Toss, Andrew R Green, Graham Ball, Ian O Ellis, Leslie W Dalton
AIMS: Virtual microscopy utilising digital whole slide imaging (WSI) is increasingly used in breast pathology. Histologic grade is one of the strongest prognostic factors in breast cancer (BC). This study aims at investigating the agreement between BC grading using traditional light microscopy (LM) and digital WSI with consideration of reproducibility and impact on outcome prediction. METHODS: A large (n=1675) well-characterised cohort of BC originally graded by LM was re-graded using WSI...
March 13, 2018: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29516649/vert-a-virtual-clinical-environment-enhances-understanding-of-radiation-therapy-planning-concepts
#16
Aidan Leong, Patries Herst, Paul Kane
INTRODUCTION: The ability to understand treatment plan dosimetry and apply this understanding clinically is fundamental to the role of the radiation therapist. This study evaluates whether or not the Virtual Environment for Radiotherapy Training (VERT) contributes to teaching treatment planning concepts to a cohort of first-year radiation therapy students. METHODS: We directly compared a custom-developed VERT teaching module with a standard teaching module with respect to the understanding of treatment planning concepts using a cross-over design...
March 8, 2018: Journal of Medical Radiation Sciences
https://www.readbyqxmd.com/read/29513855/intake-of-sugar-sweetened-beverages-milk-and-its-association-with-body-mass-index-in-adolescence-a-systematic-review
#17
Ana Carolina Corrêa Café, Carlos Alexandre de Oliveira Lopes, Rommel Larcher Rachid Novais, Wendell Costa Bila, Daniely Karoline da Silva, Márcia Christina Caetano Romano, Joel Alves Lamounier
OBJECTIVE: To systematize literature references addressing the association of sugar-sweetened beverage (SSB) and milk intake with body mass index (BMI) in adolescents. DATA SOURCE: A search was carried out in PubMed (US National Library of Medicine National Institutes of Health) and BVS (Virtual Library in Health). The descriptors used were: adolescents, young adult, beverages, drinking, obesity, overweight, BMI, and nutritional status. The following filters were applied: age ranging from 10 to 19 years, studies published in Portuguese or English language between 2011-2015...
January 2018: Revista Paulista de Pediatria: Orgão Oficial da Sociedade de Pediatria de São Paulo
https://www.readbyqxmd.com/read/29511424/the-relationship-between-mean-platelet-volume-and-fasting-plasma-glucose-and-hba1c-levels-in-a-large-cohort-of-unselected-health-check-up-participants
#18
Shinichiro Oshima, Takakazu Higuchi, Sadamu Okada, Osamu Takahashi
Background: Larger platelets are more active and mean platelet volume (MPV) is an indicator of platelet activation and an independent risk factor of cardiovascular diseases. While MPV is reported to be higher in diabetic patients, the relationship between MPV and glycemic parameters in general population remains inconclusive. Methods: In this cross-sectional study, we studied relationship between MPV and fasting plasma glucose (FPG) and HbA1c levels in 38,204 unselected participants of general health check-up aged 20 years or older in the year of 2014 who were considered to be representative of the general population...
April 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29511043/establishing-objective-benchmarks-in-robotic-virtual-reality-simulation-at-the-level-of-a-competent-surgeon-using-the-robotix-mentor-simulator
#19
William Watkinson, Nicholas Raison, Takashige Abe, Patrick Harrison, Shamim Khan, Henk Van der Poel, Prokar Dasgupta, Kamran Ahmed
BACKGROUND: To establish objective benchmarks at the level of a competent robotic surgeon across different exercises and metrics for the RobotiX Mentor virtual reality (VR) simulator suitable for use within a robotic surgical training curriculum. METHODS: This retrospective observational study analysed results from multiple data sources, all of which used the RobotiX Mentor VR simulator. 123 participants with varying experience from novice to expert completed the exercises...
March 6, 2018: Postgraduate Medical Journal
https://www.readbyqxmd.com/read/29496806/a-scoring-system-for-assessing-learning-progression-of-dental-students-clinical-skills-using-haptic-virtual-workstations
#20
Sama Ria, Margaret J Cox, Barry F Quinn, Jonathan P San Diego, Ali Bakir, Mark J Woolford
The aim of this study was to develop and test a scoring system to assess the learning progression of novice dental students using haptic virtual workstations. For the study, 101 first-year dental students at a UK dental school conducted one practice task (task 1) and four simulated cavity removal tasks (tasks 2-5) of increasing difficulty over two laboratory sessions in 2015. Performance data on the students' attempts were recorded as haptic technology-enhanced learning (hapTEL) log-files showing the percentage of caries, healthy tissue, and pulp removed...
March 2018: Journal of Dental Education
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