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https://www.readbyqxmd.com/read/28340245/unacceptable-human-leucocyte-antigens-for-organ-offers-in-the-era-of-organ-shortage-influence-on-waiting-time-before-kidney-transplantation
#1
Malte Ziemann, Nicole Heßler, Inke R König, Nils Lachmann, Andrea Dick, Vanessa Ditt, Klemens Budde, Petra Reinke, Ute Eisenberger, Barbara Suwelack, Thomas Klein, Timm H Westhoff, Wolfgang Arns, Katrin Ivens, Antje Habicht, Lutz Renders, Dirk Stippel, Dominik Bös, Florian Sommer, Siegfried Görg, Martin Nitschke, Thorsten Feldkamp, Falko M Heinemann, Reinhard Kelsch
Background.: The assignment of human leucocyte antigens (HLAs) against which antibodies are detected as unacceptable antigens (UAGs) avoids allocation of HLA- incompatible allografts. There is uncertainty as to what extent UAGs decrease the probability of receiving a kidney offer. Methods.: Kidney transplantations in 3264 patients on the waiting lists of six German transplant centres were evaluated for a period of at least 2 years. The proportion of excluded offers due to UAGs was calculated as virtual panel-reactive antibodies (vPRAs)...
March 15, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28339409/practice-based-evidence-from-a-clinical-cohort-that-received-pediatric-constraint-induced-movement-therapy
#2
Stephanie C DeLuca, Mary Rebekah Trucks, Dorian A Wallace, Sharon L Ramey
PURPOSE: Constraint-Induced Movement Therapy (CIMT) is now designated a highly efficacious treatment for children with cerebral palsy, based on rigorous clinical trials. Yet virtually no evidence confirms that these moderate to large size effects can be replicated in clinical practice for a more heterogeneous clinical population. Thus there is a need to collect and report treatment outcome data based on actual clinical practice as a critical next step for implementation. METHODS: This study presents results from a prospective study conducted on a clinical cohort of 88 children, 18 months to 12 years old (M = 55 months, SD = 5 months), who received high-intensity CIMT known as ACQUIREc...
2017: Journal of Pediatric Rehabilitation Medicine
https://www.readbyqxmd.com/read/28330651/serial-assessment-of-tissue-precursors-and%C3%A2-progression-of-coronary-calcification-analyzed-by-fusion-of-ivus-and-oct-5-year-follow-up-of-scaffolded-and-nonscaffolded-arteries
#3
Yaping Zeng, Hiroki Tateishi, Rafael Cavalcante, Erhan Tenekecioglu, Pannipa Suwannasom, Yohei Sotomi, Carlos Collet, Shaoping Nie, Hans Jonker, Jouke Dijkstra, Maria D Radu, Lorenz Räber, Dougal R McClean, Robert-Jan van Geuns, Evald H Christiansen, Therese Fahrni, Jacques Koolen, Yoshinobu Onuma, Nico Bruining, Patrick W Serruys
OBJECTIVES: The aim of this study was to assess calcium growth with fused grayscale intravascular ultrasound (IVUS), IVUS-virtual histology, and optical coherence tomography (OCT) from baseline to 5-year follow-up in patients treated with bioresorbable vascular scaffolds. BACKGROUND: IVUS and OCT have individual strengths in assessing plaque composition and volume. Fusion of images obtained using these methods could potentially aid in coronary plaque assessment...
March 10, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28327945/enhancing-knowledge-discovery-from-cancer-genomics-data-with-galaxy
#4
Marco A Albuquerque, Bruno M Grande, Elie J Ritch, Prasath Pararajalingam, Selin Jessa, Martin Krzywinski, Jasleen K Grewal, Sohrab P Shah, Paul C Boutros, Ryan D Morin
The field of cancer genomics has demonstrated the power of massively parallel sequencing techniques to inform on the genes and specific alterations that drive tumor onset and progression. Although large comprehensive sequence data sets continue to be made increasingly available, data analysis remains an ongoing challenge, particularly for laboratories lacking dedicated resources and bioinformatics expertise. To address this, we have produced a collection of Galaxy tools that represent many popular algorithms for detecting somatic genetic alterations from cancer genome and exome data...
March 9, 2017: GigaScience
https://www.readbyqxmd.com/read/28326003/effects-of-organic-food-consumption-on-human-health-the-jury-is-still-out
#5
Marcin Barański, Leonidas Rempelos, Per Ole Iversen, Carlo Leifert
The most recent systematic literature reviews and meta-analyses have indicated significant and nutritionally-relevant composition differences between organic and conventional foods. This included higher antioxidant, but lower cadmium and pesticide levels in organic crops, and higher omega-3 fatty acids concentrations in organic meat and dairy products. Also, results from a small number of human cohort studies indicate that there are positive associations between organic food consumption and reduced risk/incidence of certain acute diseases (e...
2017: Food & Nutrition Research
https://www.readbyqxmd.com/read/28291296/-the-role-of-distinctiveness-of-stimulus-in-memory-distrust-as-a-function-of-repeated-checking
#6
Talat Demirsöz, H Belgin Ayvaşık
OBJECTIVE: Recent literature proposes that repeated checking increases familiarity with the material, making recollections less vivid and detailed and promoting distrust in memory. The aim of the current study is to investigate the possible underlying mechanisms of low confidence in memory. METHOD: The Padua Inventory-Washington State University Revision (PI-WSUR) was applied in a cohort of university students. Among the students who completed the PI-WSUR, 84 participants were selected and assigned to low Obsessive-Compulsive Symptomatology (OCS) group or high OCS group according to their PI-WSUR scores...
2017: Türk Psikiyatri Dergisi, Turkish Journal of Psychiatry
https://www.readbyqxmd.com/read/28288604/hiv-prevalence-and-uptake-of-hiv-aids-services-among-youths-15-24-years-in-fishing-and-neighboring-communities-of-kasensero-rakai-district-south-western-uganda
#7
Richardson Mafigiri, Joseph K B Matovu, Fredrick Edward Makumbi, Anthony Ndyanabo, Doreen Nabukalu, Moses Sakor, Godfrey Kigozi, Fred Nalugoda, Rhoda K Wanyenze
BACKGROUND: Although fishing communities have a significantly higher HIV prevalence than the general population, there is paucity of data on the burden of HIV and service utilization, particularly among the youth. We assessed the HIV prevalence and utilization of HIV prevention and treatment services among youth in Kasensero fishing community and the neighboring communities. METHOD: Data were derived from the Rakai Community Cohort Study (RCCS) surveys conducted between 2013 and 2014...
March 14, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28271121/medication-use-among-veterans-across-health-care-systems
#8
Khoa A Nguyen, David A Haggstrom, Susan Ofner, Susan M Perkins, Dustin D French, Laura J Myers, Marc Rosenman, Michael Weiner, Brian E Dixon, Alan J Zillich
INTRODUCTION: Dual healthcare system use can create gaps and fragments of information for patient care. The Department of Veteran Affairs is implementing a health information exchange (HIE) program called the Virtual Lifetime Electronic Record (VLER), which allows providers to access and share information across healthcare systems. HIE has the potential to improve the safety of medication use. However, data regarding the pattern of outpatient medication use across systems of care is largely unknown...
March 8, 2017: Applied Clinical Informatics
https://www.readbyqxmd.com/read/28267622/effectiveness-of-hepatitis-c-antiviral-treatment-in-a-usa-cohort-of-veteran-patients-with-hepatocellular-carcinoma
#9
Lauren A Beste, Pamela K Green, Kristin Berry, Matthew J Kogut, Stephen K Allison, George N Ioannou
BACKGROUND & AIMS: Hepatitis C virus (HCV) treatment for patients with hepatocellular carcinoma (HCC) was uncommon before direct acting antiviral (DAA) medications. Real-world effectiveness of DAAs for HCV in patients with HCC is unclear. We describe rates of sustained virologic response (SVR) with DAA regimens by HCV genotype in patients with history of HCC. METHODS: We identified patients who initiated antiviral treatment between January 1, 2014 and June 30, 2015 in the national Veterans Affairs health care system...
March 3, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28259737/medication-adherence-molecular-monitoring-and-clinical-outcomes-in-patients-with-chronic-myelogenous-leukemia-in-a-large-hmo
#10
Reina Haque, Jiaxiao Shi, Joanie Chung, Xiaoqing Xu, Chantal Avila, Christopher Campbell, Syed A Ahmed, Lei Chen, Joanne E Schottinger
OBJECTIVE: Our objective was to examine the association between adherence to tyrosine kinase inhibitors (TKIs) and molecular monitoring and the risk of disease progression or mortality among patients with chronic phase chronic myeloid leukemia (CML). DESIGN: We assembled a retrospective cohort of patients with CML (chronic phase, no prior cancer history, and confirmed to be Philadelphia chromosome positive) using data from electronic health records and chart reviews...
March 1, 2017: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/28258513/higher-body-mass-index-in-16-19-year-old-jewish-adolescents-of-north-african-middle-eastern-and-european-origins-is-a-predictor-of-acute-myeloid-leukemia-a-cohort-of-2-3%C3%A2-million-israelis
#11
Oded Shamriz, Merav Leiba, Hagai Levine, Estela Derazne, Lital Keinan-Boker, Jeremy D Kark
PURPOSE: Studies evaluating adolescent risk factors for developing acute myeloid leukemia (AML) are virtually nonexistent. We assessed adolescent predictors of AML in adults, with a main focus on adolescent BMI. METHODS: The study included 2,310,922 16-19-year-old Jewish Israeli adolescents (mean age 17.3 ± 0.4, 59.5% male), called up for an obligatory health examination. Sociodemographic and health data, including measured weight and height, were gathered...
March 3, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28229076/locoregional-therapies-of-cholangiocarcinoma
#12
REVIEW
Christof M Sommer, Hans U Kauczor, Philippe L Pereira
BACKGROUND: Cholangiocarcinoma (CC) is the second most primary liver malignancy with increasing incidence in Western countries. Currently, surgical R0 resection is regarded as the only potentially curative treatment. The results of systemic chemotherapy and best supportive care (BSC) in patients with metastatic disease are often disappointing in regard to toxicity, oncologic efficacy, and overall survival. In current practice, the use of different locoregional therapies is increasingly more accepted...
December 2016: Visceral Medicine
https://www.readbyqxmd.com/read/28214469/cost-benefit-analysis-of-chlamydia-trachomatis-screening-in-pregnant-women-in-a-high-burden-setting-in-the-united-states
#13
Jared Ditkowsky, Khushal H Shah, Margaret R Hammerschlag, Stephan Kohlhoff, Tamar A Smith-Norowitz
BACKGROUND: Chlamydia trachomatis is the most common bacterial sexually transmitted infection (STI) in the United States (U.S.) [1] and remains a major public health problem. We determined the cost- benefit of screening all pregnant women aged 15-24 for Chlamydia trachomatis infection compared with no screening. METHODS: We developed a decision analysis model to estimate costs and health-related effects of screening pregnant women for C. trachomatis in a high burden setting (Brooklyn, NY)...
February 18, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28191877/a-virtual-clinical-trial-comparing-static-versus-dynamic-pet-imaging-in-measuring-response-to-breast-cancer-therapy
#14
Kristen A Wangerin, Mark Muzi, Lanell Peterson, Hannah Linden, Alena Novakova, David Mankoff, Paul Kinahan
OBJECTIVE: We developed a method to evaluate variations in the PET imaging process in order to characterize the relative ability of static and dynamic metrics to measure breast cancer response to therapy in a clinical trial setting. METHODS: We performed a virtual clinical trial by generating 540 i.i.d. PET imaging study realizations for each of 22 original dynamic fluorodeoxyglucose (18F-FDG) breast cancer patient studies pre- and post-therapy. Each noise realization accounted for known sources of uncertainty in the imaging process, such as biological variability and SUV uptake time...
February 13, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28187069/virtual-modeling-of-postoperative-alignment-following-adult-spinal-deformity-asd-surgery-helps-predict-associations-between-compensatory-spinopelvic-alignment-changes-overcorrection-and-proximal-junctional-kyphosis-pjk
#15
Renaud Lafage, Shay Bess, Steve Glassman, Christopher Ames, Doug Burton, Robert Hart, Han Jo Kim, Eric Klineberg, Jensen Henry, Breton Line, Justin Scheer, Themistocles Protopsaltis, Frank Schwab, Virginie Lafage
STUDY DESIGN: Retrospective review of a prospective multicenter database. OBJECTIVE: To develop a method to analyze sagittal alignment, free of PJK's influence, and then compare PJK to non-PJK patients using this method. SUMMARY OF BACKGROUND DATA: Proximal Junctional Kyphosis (PJK) following Adult Spinal Deformity (ASD) surgery remains problematic as it alters sagittal alignment. This study proposes a novel virtual modeling technique that attempts to eliminate the confounding effects of PJK on postoperative spinal alignment...
February 9, 2017: Spine
https://www.readbyqxmd.com/read/28186983/differentiation-status-of-primary-chronic-myeloid-leukemia-cells-affects-sensitivity-to-bcr-abl1-inhibitors
#16
Paavo O Pietarinen, Christopher A Eide, Pilar Ayuda-Durán, Swapnil Potdar, Heikki Kuusanmäki, Emma I Andersson, John P Mpindi, Tea Pemovska, Mika Kontro, Caroline A Heckman, Olli Kallioniemi, Krister Wennerberg, Henrik Hjorth-Hansen, Brian J Druker, Jorrit M Enserink, Jeffrey W Tyner, Satu Mustjoki, Kimmo Porkka
Tyrosine kinase inhibitors (TKI) are the mainstay treatment of BCR-ABL1-positive leukemia and virtually all patients with chronic myeloid leukemia in chronic phase (CP CML) respond to TKI therapy. However, there is limited information on the cellular mechanisms of response and particularly on the effect of cell differentiation state to TKI sensitivity in vivo and ex vivo/in vitro. We used multiple, independent high-throughput drug sensitivity and resistance testing platforms that collectively evaluated 295 oncology compounds to characterize ex vivo drug response profiles of primary cells freshly collected from newly-diagnosed patients with BCR-ABL1-positive leukemia (n = 40) and healthy controls (n = 12)...
February 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28178995/reference-ranges-for-cardiac-structure-and-function-using-cardiovascular-magnetic-resonance-cmr-in-caucasians-from-the-uk-biobank-population-cohort
#17
Steffen E Petersen, Nay Aung, Mihir M Sanghvi, Filip Zemrak, Kenneth Fung, Jose Miguel Paiva, Jane M Francis, Mohammed Y Khanji, Elena Lukaschuk, Aaron M Lee, Valentina Carapella, Young Jin Kim, Paul Leeson, Stefan K Piechnik, Stefan Neubauer
BACKGROUND: Cardiovascular magnetic resonance (CMR) is the gold standard method for the assessment of cardiac structure and function. Reference ranges permit differentiation between normal and pathological states. To date, this study is the largest to provide CMR specific reference ranges for left ventricular, right ventricular, left atrial and right atrial structure and function derived from truly healthy Caucasian adults aged 45-74. METHODS: Five thousand sixty-five UK Biobank participants underwent CMR using steady-state free precession imaging at 1...
February 3, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/28176034/patient-satisfaction-with-virtual-obstetric-care
#18
Bethann Mangel Pflugeisen, Jin Mou
Introduction The importance of patient satisfaction in US healthcare is increasing, in tandem with the advent of new patient care modalities, including virtual care. The purpose of this study was to compare the satisfaction of obstetric patients who received one-third of their antenatal visits in videoconference ("Virtual-care") compared to those who received 12-14 face-to-face visits in-clinic with their physician/midwife ("Traditional-care"). Methods We developed a four-domain satisfaction questionnaire; Virtual-care patients were asked additional questions about technology...
February 7, 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/28174552/measuring-mindreading-a-review-of-behavioral-approaches-to-testing-cognitive-and-affective-mental-state-attribution-in-neurologically-typical-adults
#19
REVIEW
Rose Turner, Fatima M Felisberti
Mindreading refers to the ability to attribute mental states, including thoughts, intentions and emotions, to oneself and others, and is essential for navigating the social world. Empirical mindreading research has predominantly featured children, groups with autism spectrum disorder and clinical samples, and many standard tasks suffer ceiling effects with neurologically typical (NT) adults. We first outline a case for studying mindreading in NT adults and proceed to review tests of emotion perception, cognitive and affective mentalizing, and multidimensional tasks combining these facets...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28152846/cancer-communication-in-the-social-media-age-could-twitter-help-clinical-trial-accrual
#20
Roger B Cohen, Raina M Merchant, Marilyn M Schapira
194 Background: Twitter, a social networking site, is transforming communication. Effective use of Twitter might be one way to communicate with the public about cancer clinical trials and increase awareness and perhaps enrollment. We conducted a content analysis of tweets about lung cancer, describing dialogues specific to lung cancer clinical trials and seeing where embedded-links in tweets about therapeutic trials are leading the public. METHODS: We used the Twitter search engine to identify a cohort of 26,059 tweets with the keyword "lung cancer" from January 5 - 21, 2015...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
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