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https://www.readbyqxmd.com/read/28089607/estimates-of-nasal-airflow-at-the-nasal-cycle-mid-point-improve-the-correlation-between-objective-and-subjective-measures-of-nasal-patency
#1
Courtney Gaberino, John S Rhee, Guilherme J M Garcia
INTRODUCTION: The nasal cycle represents a significant challenge when comparing pre- and post-surgery objective measures of nasal airflow. METHODS: Computational fluid dynamics (CFD) simulations of nasal airflow were conducted in 12 nasal airway obstruction patients showing significant nasal cycling between pre- and post-surgery computed tomography scans. To correct for the nasal cycle, mid-cycle models were created virtually. Subjective scores of nasal patency were obtained via the Nasal Obstruction Symptom Evaluation (NOSE) and unilateral visual analog scale (VAS)...
January 9, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/28078758/periconceptional-maternal-high-fish-and-olive-oil-low-meat-dietary-pattern-is-associated-with-increased-embryonic-growth-the-rotterdam-periconceptional-cohort-predict-study
#2
Francesca Parisi, Melek Rousian, Nicole A Huijgen, Anton H J Koning, Sten P Willemsen, Jeanne H M de Vries, Irene Cetin, Eric A P Steegers, Régine P M Steegers-Theunissen
OBJECTIVE: To investigate associations between periconceptional maternal dietary patterns and first trimester embryonic growth. METHODS: 228 women with singleton ongoing pregnancies were enrolled in a prospective periconceptional cohort study, comprising of 135 strictly dated spontaneous pregnancies and 93 pregnancies achieved after in vitro fertilization or intracytoplasmatic sperm injection (IVF/ICSI pregnancies). All women underwent longitudinal transvaginal three-dimensional ultrasound (3D-US) scans from 6(+0) up to 13(+0) weeks of gestation...
January 12, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28077109/cause-of-neonatal-deaths-in-northern-ethiopia-a-prospective-cohort-study
#3
Hayelom Gebrekirstos Mengesha, Berhe W Sahle
BACKGROUND: Despite the significant reduction in childhood mortality, neonatal mortality has shown little or no concomitant decline worldwide. The dilemma arises in that the lack of documentation of cause of death in developing countries, where registration of vital events is virtually nonexistent. Understanding of the causes of death in neonates is important to guide public health interventions. The present study identifies the common causes of neonatal death in Ethiopia. METHODS: A prospective cohort study was conducted among neonates born between April 2014 and July 2014 in seven hospitals, in Tigray region, Ethiopia...
January 11, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28073052/deciduous-neonatal-line-width-is-associated-with-duration-of-delivery
#4
Jaana Hurnanen, Vivian Visnapuu, Matti Sillanpää, Eliisa Löyttyniemi, Jaana Rautava
The delivery-related neonatal line (NNL) appears into the enamel of primary teeth and first permanent molars at birth and is a marker of live birth process. It varies in width and its location, is different in each deciduous tooth type, and is indicative of gestation time. It is unclear which triggers determine NNL at birth. Our objective was to investigate the effect of the duration and mode of delivery on NNL width. NNL of 129 teeth, a collection derived from a long-term, prospectively followed population cohort, was measured under light microscope...
December 21, 2016: Forensic Science International
https://www.readbyqxmd.com/read/28069173/periconceptional-maternal-biomarkers-of-one-carbon%C3%A2-metabolism-and-embryonic-growth-trajectories-the-rotterdam-periconceptional-cohort-predict-study
#5
Francesca Parisi, Melek Rousian, Anton H J Koning, Sten P Willemsen, Irene Cetin, Eric A P Steegers, Régine P M Steegers-Theunissen
OBJECTIVE: To study the associations between the periconceptional maternal biomarkers of one-carbon metabolism and embryonic growth. DESIGN: Prospective, periconceptional hospital-based birth cohort. SETTING: Tertiary medical care center. PATIENT(S): Between 2010 and 2014, 236 women with early singleton ongoing pregnancies that resulted in 139 strictly dated spontaneous pregnancies and 97 pregnancies conceived after assisted reproductive technology...
January 6, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28038897/herbal-supplements-association-with-reversible-cerebral-vasoconstriction-syndrome-a-case-report
#6
Isabel Costa, Marcelo D Mendonça, Vera Cruz E Silva, Sofia Calado, Miguel Viana-Baptista
BACKGROUND: Reversible cerebral vasoconstriction syndrome (RCVS) is a clinico-radiologic syndrome characterized by thunderclap headache and reversible multifocal arterial constrictions that resolves within 3 months. RCVS can be either spontaneous or related to a trigger; vasoactive drugs including over-the-counter medicine are common culprits. Nevertheless, there are sparse data on the association of herbal supplements in the genesis of unexplained RCVS. METHODS: We describe a case of RCVS with a temporal association with the consumption of a diet pill composed of green tea, L-carnitine, and conjugated linoleic acid...
December 27, 2016: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28027600/comparison-of-long-term-outcomes-and-quality-of-life-in-recipients-of-donation-after-cardiac-death-liver-grafts-with-a-propensity-matched-cohort
#7
K P Croome, D D Lee, D K Perry, J M Burns, J H Nguyen, A P Keaveny, C B Taner
BACKGROUND: The use of liver grafts from donation after cardiac death donors (DCD LT) has been limited due to the increased rate of graft failure, mostly related to ischemic cholangiopathy(IC). It is our hypothesis that long term outcomes and quality of life similar to patients undergoing liver transplantation with donation after brain death donors (DBD LT) can be achieved. METHODS: Clinical outcomes of all patients undergoing DCD LT (n = 300) between 1998-2015 were compared to a propensity score matched cohort of patients undergoing DBD LT (n = 300)...
December 27, 2016: Liver Transplantation
https://www.readbyqxmd.com/read/27988433/igg4-related-disease-evidence-from-six-recent-cohorts
#8
REVIEW
Fernando Martínez-Valle, Andreu Fernández-Codina, Iago Pinal-Fernández, Olimpia Orozco-Gálvez, Miquel Vilardell-Tarrés
IgG4-related disease (IgG4-RD) is a rare autoimmune fibrosing disorder. In this review we aim to describe and compare the characteristics of the six largest IgG4-RD cohorts, since the new 2012 consensus diagnostic criteria were released. These observational studies were published between 2012 and 2015. Patients were included using the comprehensive diagnostic criteria or the 2012 consensus criteria. Results were reviewed and summarized. Most patients were middle aged men. Fibro-inflammatory masses developed in virtually all organs except the brain, with an unexplained preference for salivary glands, lymph nodes and pancreas...
December 15, 2016: Autoimmunity Reviews
https://www.readbyqxmd.com/read/27982025/morphological-characterization-of-colorectal-cancers-in-the-cancer-genome-atlas-reveals-distinct-morphology-molecular-associations-clinical-and-biological-implications
#9
Jinru Shia, Nikolaus Schultz, Deborah Kuk, Efsevia Vakiani, Sumit Middha, Neil H Segal, Jaclyn F Hechtman, Michael F Berger, Zsofia K Stadler, Martin R Weiser, Jedd D Wolchok, C Richard Boland, Mithat Gönen, David S Klimstra
The Cancer Genome Atlas data on colorectal carcinoma have provided a comprehensive view of the tumor's genomic alterations and their tumorigenic roles. Tumor morphology, however, has not been fully integrated into the analysis. The aim of this study was to explore relevant associations between tumor morphology and the newly characterized genomic alterations in colorectal carcinoma. Two hundred and seven colorectal carcinomas that had undergone whole-exome sequencing as part of The Cancer Genome Atlas project and had adequate virtual images in the cBioPortal for Cancer Genomics constituted our study population...
December 16, 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/27981866/influence-of-videogames-and-musical-instruments-on-performances-at-a-simulator-for-robotic-surgery
#10
Andrea Moglia, Vittorio Perrone, Vincenzo Ferrari, Luca Morelli, Ugo Boggi, Mauro Ferrari, Franco Mosca, Alfred Cuschieri
OBJECTIVE: To assess if exposure to videogames, musical instrument playing, or both influence the psychomotor skills level, assessed by a virtual reality simulator for robot-assisted surgery (RAS). MATERIALS AND METHODS: A cohort of 57 medical students were recruited: playing musical instruments (group 1), videogames (group 2), both (group 3), and no activity (group 4); all students executed four exercises on a virtual simulator for RAS. RESULTS: Subjects from group 3 achieved the best performances on overall score: 527...
December 16, 2016: Minimally Invasive Therapy & Allied Technologies: MITAT
https://www.readbyqxmd.com/read/27957505/bacterial-colonization-and-antibiotic-resistance-in-a-prospective-cohort-of-newborn-infants-during-the-first-year-of-life
#11
Sharon B Meropol, Kurt C Stange, Michael R Jacobs, Judith K Weiss, Saralee Bajaksouzian, Robert A Bonomo
BACKGROUND: Infants are virtually sterile at birth and frequently use antibiotics; our objective was to (1) characterize the longitudinal colonization with bacterial pathogens and associated antibiotic resistance in a cohort of community-dwelling infants in Northeast Ohio and (2) describe longitudinal concurrent antibiotic and daycare exposures. METHODS: For 35 newborns, nasopharyngeal swabs were cultured for Streptococcus pneumoniae, anterior nasal for Staphylococcus aureus, and perirectal for extended-spectrum beta-lactamase (ESBL)-producing Gram-negative enteric bacteria, at 3-month intervals for 12 months...
October 2016: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/27955651/learning-pathology-using-collaborative-vs-individual-annotation-of-whole-slide-images-a-mixed-methods-trial
#12
Michael Sahota, Betty Leung, Stephanie Dowdell, Gary M Velan
BACKGROUND: Students in biomedical disciplines require understanding of normal and abnormal microscopic appearances of human tissues (histology and histopathology). For this purpose, practical classes in these disciplines typically use virtual microscopy, viewing digitised whole slide images in web browsers. To enhance engagement, tools have been developed to enable individual or collaborative annotation of whole slide images within web browsers. To date, there have been no studies that have critically compared the impact on learning of individual and collaborative annotations on whole slide images...
December 12, 2016: BMC Medical Education
https://www.readbyqxmd.com/read/27915227/prenatal-and-postnatal-polybrominated-diphenyl-ether-exposure-and-visual-spatial-abilities-in-children
#13
Ann M Vuong, Joseph M Braun, Kimberly Yolton, Changchun Xie, Glenys M Webster, Andreas Sjödin, Kim N Dietrich, Bruce P Lanphear, Aimin Chen
Polybrominated diphenyl ethers (PBDEs) are associated with impaired visual spatial abilities in toxicological studies, but no epidemiologic study has investigated PBDEs and visual spatial abilities in children. The Health Outcomes and Measures of the Environment Study, a prospective birth cohort (2003-2006, Cincinnati, OH), was used to examine prenatal and childhood PBDEs and visual spatial abilities in 199 children. PBDEs were measured at 16±3 weeks gestation and at 1, 2, 3, 5, and 8 years using gas chromatography/isotope dilution high-resolution mass spectrometry...
February 2017: Environmental Research
https://www.readbyqxmd.com/read/27898991/nipple-and-areola-sparing-mastectomy-for-the-treatment-of-breast-cancer
#14
REVIEW
Bruna S Mota, Rachel Riera, Marcos Desidério Ricci, Jessica Barrett, Tiago B de Castria, Álvaro N Atallah, Jose Luiz B Bevilacqua
BACKGROUND: The efficacy and safety of nipple-sparing mastectomy and areola-sparing mastectomy for the treatment of breast cancer are still questionable. It is estimated that the local recurrence rates following nipple-sparing mastectomy are very similar to breast-conserving surgery followed by radiotherapy. OBJECTIVES: To assess the efficacy and safety of nipple-sparing mastectomy and areola-sparing mastectomy for the treatment of ductal carcinoma in situ and invasive breast cancer in women...
29, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27888119/prenatal-phthalate-triclosan-and-bisphenol-a-exposures-and-child-visual-spatial-abilities
#15
Joseph M Braun, David C Bellinger, Russ Hauser, Robert O Wright, Aimin Chen, Antonia M Calafat, Kimberly Yolton, Bruce P Lanphear
INTRODUCTION: During fetal development, sex steroids influence sexually dimorphic behaviors, such as visual-spatial abilities. Thus, endocrine disrupting chemicals that impact sex steroids during gestation may affect these behaviors. OBJECTIVE: We investigated the relationship between prenatal urinary phthalate metabolite, triclosan, and BPA concentrations and visual-spatial abilities in a prospective cohort of 198 mother-child dyads. METHODS: Data are from a prospective cohort in Cincinnati, OH (HOME Study)...
November 23, 2016: Neurotoxicology
https://www.readbyqxmd.com/read/27884959/cardiac-responses-to-exercise-distinguish-postural-orthostatic-tachycardia-syndrome-variants
#16
Paolo T Pianosi, Darrell R Schroeder, Philip R Fischer
We previously showed that one-third of adolescents with postural orthostatic tachycardia syndrome (POTS) have hyperkinetic circulation. In a subsequent cohort, we compare participants with POTS grouped according to cardiac output (Q˙) versus oxygen uptake (V˙O2) function, whose circulatory response to exercise lay at the lower end of this distribution. We hypothesized that such grouping determines the circulatory response to incremental-protocol, upright, cycle ergometry by whatever blend of flow and resistance adjustments best maintains normal blood pressure...
November 2016: Physiological Reports
https://www.readbyqxmd.com/read/27884677/mastery-based-virtual-reality-robotic-simulation-curriculum-the-first-step-toward-operative-robotic-proficiency
#17
Melissa E Hogg, Vernissia Tam, Mazen Zenati, Stephanie Novak, Jennifer Miller, Amer H Zureikat, Herbert J Zeh
OBJECTIVE: Hepatobiliary surgery is a highly complex, low-volume specialty with long learning curves necessary to achieve optimal outcomes. This creates significant challenges in both training and measuring surgical proficiency. We hypothesize that a virtual reality curriculum with mastery-based simulation is a valid tool to train fellows toward operative proficiency. This study evaluates the content and predictive validity of robotic simulation curriculum as a first step toward developing a comprehensive, proficiency-based pathway...
November 21, 2016: Journal of Surgical Education
https://www.readbyqxmd.com/read/27856475/assessment-of-cardiovascular-remodelling-following-endovascular-aortic-repair-through-imaging-and-computation-the-core-prospective-observational-cohort-study-protocol
#18
Foeke J H Nauta, Arnoud V Kamman, El-Sayed H Ibrahim, Prachi P Agarwal, Bo Yang, Karen Kim, David M Williams, Joost A van Herwaarden, Frans L Moll, Kim A Eagle, Santi Trimarchi, Himanshu J Patel, C Alberto Figueroa
INTRODUCTION: Thoracic aortic stent grafts are orders of magnitude stiffer than the native aorta. These devices have been associated with acute hypertension, elevated pulse pressure, cardiac remodelling and reduced coronary perfusion. However, a systematic assessment of such cardiovascular effects of thoracic endovascular aortic repair (TEVAR) is missing. The CardiOvascular Remodelling following Endovascular aortic repair (CORE) study aims to (1) quantify cardiovascular remodelling following TEVAR and compare echocardiography against MRI, the reference method; (2) validate computational modelling of cardiovascular haemodynamics following TEVAR using clinical measurements, and virtually assess the impact of more compliant stent grafts on cardiovascular haemodynamics; and (3) investigate diagnostic accuracy of ECG and serum biomarkers for cardiac remodelling compared to MRI...
November 17, 2016: BMJ Open
https://www.readbyqxmd.com/read/27855681/using-telehealth-to-support-end-of-life-care-in-the-community-a-feasibility-study
#19
Jennifer J Tieman, Kate Swetenham, Deidre D Morgan, Timothy H To, David C Currow
BACKGROUND: Telehealth is being used increasingly in providing care to patients in the community setting. Telehealth enhanced service delivery could offer new ways of managing load and care prioritisation for palliative care patients living in the community. The study assesses the feasibility of a telehealth-based model of service provision for community based palliative care patients, carers and clinicians. METHODS: This study was a prospective cohort study of a telehealth-based intervention for community based patients of a specialist palliative care service living in Southern Adelaide, South Australia...
November 17, 2016: BMC Palliative Care
https://www.readbyqxmd.com/read/27847847/inter-observer-agreement-between-2-dimensional-ct-versus-3-dimensional-i-space-model-in-the-diagnosis-of-occult-scaphoid-fractures
#20
Tessa Drijkoningen, Robert Knoter, Emile G Coerkamp, Anton H J Koning, Steven J Rhemrev, Frank J Beeres
BACKGROUND: The I-Space is a radiological imaging system in which Computed Tomography (CT)-scans can be evaluated as a three dimensional hologram. The aim of this study is to analyze the value of virtual reality (I-Space) in diagnosing acute occult scaphoid fractures. METHODS: A convenient cohort of 24 patients with a CT-scan from prior studies, without a scaphoid fracture on radiograph, yet high clinical suspicion of a fracture, were included in this study. CT-scans were evaluated in the I-Space by 7 observers of which 3 observers assessed the scans in the I-Space twice...
October 2016: Archives of Bone and Joint Surgery
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