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Sofie Søndergaard Mørch, Johnny Dohn Holmgren Andersen, Morten Heiberg Bestle
Hyperthermia is an uncontrolled elevation of body temperature exceeding the body's ability to dissipate heat. Hyperthermia can result in dangerously high core temperatures and can rapidly become fatal. Common causes include heat stroke, malignant hyperthermia, serotonin syndrome, neuroleptic syndrome, a few endocrine emergencies as well as numerous intoxications. Rapid diagnosis and prompt cooling are pivotal, since the condition triggers a cascade of metabolic events which may progress to irreversible injury or death...
July 24, 2017: Ugeskrift for Laeger
L Terslev, A P Diamantopoulos, U Møller Døhn, W A Schmidt, S Torp-Pedersen
Ultrasound is used increasingly for diagnosing large vessel vasculitis (LVV). The application of Doppler in LVV is very different from in arthritic conditions. This paper aims to explain the most important Doppler parameters, including spectral Doppler, and how the settings differ from those used in arthritic conditions and provide recommendations for optimal adjustments. This is addressed through relevant Doppler physics, focusing, for example, on the Doppler shift equation and how angle correction ensures correctly displayed blood velocity...
July 20, 2017: Arthritis Research & Therapy
Hyukki Lee, Soohyung Kim, Jong Wook Kim, Yon Dohn Chung
BACKGROUND: Publishing raw electronic health records (EHRs) may be considered as a breach of the privacy of individuals because they usually contain sensitive information. A common practice for the privacy-preserving data publishing is to anonymize the data before publishing, and thus satisfy privacy models such as k-anonymity. Among various anonymization techniques, generalization is the most commonly used in medical/health data processing. Generalization inevitably causes information loss, and thus, various methods have been proposed to reduce information loss...
July 11, 2017: BMC Medical Informatics and Decision Making
Karin Holmsten, Line Dohn, Niels Viggo Jensen, Carl-Henrik Shah, Fredrik Jäderling, Helle Pappot, Anders Ullén
[This corrects the article DOI: 10.3892/ol.2016.4775.].
June 2017: Oncology Letters
Katrine Qvortrup, Rico G Petersen, Asmus O Dohn, Klaus B Møller, Thomas E Nielsen
The synthetic utility and theoretical basis of a photolabile hydroxylamine-linker are presented. The developed protocols enable the efficient synthesis and chemoselective photolytic release of either hydroxamates or carboxamides from solid support. The bidetachable mode of the linker unit is uniquely dependent on the solvent. Hydroxamic acids are obtained by performing photolysis in protic solvents, whereas photolysis in aprotic solvents enables the selective release of carboxamides.
June 1, 2017: Organic Letters
Soohyung Kim, Hyukki Lee, Yon Dohn Chung
INTRODUCTION: The aim of this study is to evaluate the effectiveness and efficiency of privacy-preserving data cubes of electronic medical records (EMRs). An EMR data cube is a complex of EMR statistics that are summarized or aggregated by all possible combinations of attributes. Data cubes are widely utilized for efficient big data analysis and also have great potential for EMR analysis. For safe data analysis without privacy breaches, we must consider the privacy preservation characteristics of the EMR data cube...
January 2017: International Journal of Medical Informatics
Tim B van Driel, Kasper S Kjær, Robert W Hartsock, Asmus O Dohn, Tobias Harlang, Matthieu Chollet, Morten Christensen, Wojciech Gawelda, Niels E Henriksen, Jong Goo Kim, Kristoffer Haldrup, Kyung Hwan Kim, Hyotcherl Ihee, Jeongho Kim, Henrik Lemke, Zheng Sun, Villy Sundström, Wenkai Zhang, Diling Zhu, Klaus B Møller, Martin M Nielsen, Kelly J Gaffney
The interactions between the reactive excited state of molecular photocatalysts and surrounding solvent dictate reaction mechanisms and pathways, but are not readily accessible to conventional optical spectroscopic techniques. Here we report an investigation of the structural and solvation dynamics following excitation of a model photocatalytic molecular system [Ir2(dimen)4](2+), where dimen is para-diisocyanomenthane. The time-dependent structural changes in this model photocatalyst, as well as the changes in the solvation shell structure, have been measured with ultrafast diffuse X-ray scattering and simulated with Born-Oppenheimer Molecular Dynamics...
November 28, 2016: Nature Communications
Wujie Zhang, Matthew J Bissen, Emily S Savela, Joshua N Clausen, Samantha J Fredricks, Xiaoru Guo, Zachary R Paquin, Ryan P Dohn, Ian J Pavelich, Alec L Polovchak, Michael J Wedemeyer, Brock E Shilling, Emily N Dufner, Anna C O'Donnell, Gerardo Rubio, Logan R Readnour, Tyler F Brown, Jung C Lee, Matey G Kaltchev, Junhong Chen, Charles S Tritt
PURPOSE: To improve the stability of pectin-oligochitosan hydrogel microcapsules under physiological conditions. METHODS: Two different approaches were examined: change of the cross-linker length and treatment of the hydrogel microcapsules with 150 Mm CaCl2. Replacement of pectin with alginate was also studied. RESULTS AND CONCLUSIONS: It was observed that the molecular weight of the cross-linker oligochiotsan had no significant improvement on microcapsule stability...
November 16, 2016: International Journal of Artificial Organs
Justin Dohn, David J Augustine, Niall P Hanan, Jayashree Ratnam, Mahesh Sankaran
The majority of research on savanna vegetation dynamics has focused on the coexistence of woody and herbaceous vegetation. Interactions among woody plants in savannas are relatively poorly understood. We present data from a 10-yr longitudinal study of spatially explicit growth patterns of woody vegetation in an East African savanna following exclusion of large herbivores and in the absence of fire. We examined plant spatial patterns and quantified the degree of competition among woody individuals. Woody plants in this semiarid savanna exhibit strongly clumped spatial distributions at scales of 1-5 m...
February 2017: Ecology
Asmus O Dohn, Kasper S Kjær, Tobias B Harlang, Sophie E Canton, Martin M Nielsen, Klaus B Møller
This work provides a detailed mechanism for electron transfer in a heterodinuclear complex designed as a model system in which to study homogeneous molecular photocatalysis. With efficient Born-Oppenheimer molecular dynamics simulations, we show how intermediate, charge-separated states can mediate the electron transfer. We observe how Jahn-Teller distortion effects play out in solution, when the molecule has energetically close-lying states, and how this distortion is averaged out in the thermal sampling. Finally, we demonstrate how the solvent helps stabilize and localize the separated charge...
October 4, 2016: Inorganic Chemistry
S Krabbe, R Bolce, C H Brahe, U M Døhn, B J Ejbjerg, M L Hetland, E H Sasso, D Chernoff, M S Hansen, L S Knudsen, A Hansen, O R Madsen, M Hasselquist, J Møller, M Østergaard
OBJECTIVES: To investigate the multi-biomarker disease activity (MBDA) score by comparison with imaging findings in an investigator-initiated rheumatoid arthritis (RA) trial (HURRAH trial, NCT00696059). METHOD: Fifty-two patients with established RA initiated adalimumab treatment and had magnetic resonance imaging (MRI), ultrasonography (US), computed tomography (CT), and radiography performed at weeks 0, 26, and 52. Serum samples were analysed using MBDA score assays and associations between clinical measures, MBDA score, and imaging findings were investigated...
September 28, 2016: Scandinavian Journal of Rheumatology
Mads Ammitzbøll-Danielsen, Mikkel Østergaard, Viktoria Fana, Daniel Glinatsi, Uffe Møller Døhn, Lykke Midtbøll Ørnbjerg, Esperanza Naredo, Lene Terslev
OBJECTIVE: The aim of this study was to compare the efficacy of intramuscular versus ultrasound (US)-guided intratenosynovial glucocorticoid injection in providing disease control after 2, 4 and 12 weeks in patients with rheumatoid arthritis(RA) with tenosynovitis. METHODS: Fifty patients with RA and tenosynovitis were randomised into two double-blind groups: (A) 'intramuscular group', receiving intramuscular injection of betamethasone and US-guided intratenosynovial isotonic saline injection and (B) 'intratenosynovial group' receiving saline intramuscularly and US-guided intratenosynovial betamethasone injection...
April 2017: Annals of the Rheumatic Diseases
Kristoffer Haldrup, Asmus O Dohn, Megan L Shelby, Michael W Mara, Andrew B Stickrath, Michael R Harpham, Jier Huang, Xiaoyi Zhang, Klaus B Møller, Arnab Chakraborty, Felix N Castellano, David M Tiede, Lin X Chen
Pyrazolate-bridged dinuclear Pt(II) complexes represent a series of molecules with tunable absorption and emission properties that can be directly modulated by structural factors, such as the Pt-Pt distance. However, direct experimental information regarding the structure of the emissive triplet excited state has remained scarce. Using time-resolved wide-angle X-ray scattering (WAXS), the excited triplet state molecular structure of [Pt(ppy)(μ-t-Bu2pz)]2 (ppy = 2-phenylpyridine; t-Bu2pz = 3,5-di-tert-butylpyrazolate), complex 1, was obtained in a dilute (0...
September 29, 2016: Journal of Physical Chemistry. A
Karin Holmsten, Line Dohn, Niels Viggo Jensen, Carl-Henrik Shah, Fredrik Jäderling, Helle Pappot, Anders Ullén
In 2009, vinflunine was introduced as a second-line treatment to be used after the failure of platinum therapy in patients with metastatic urothelial carcinoma (mUC). The present study investigated the administered vinflunine to patients with mUC in standard clinical practice with the aim of evaluating treatment patterns, response, survival parameters and side-effects. Data were collected retrospectively from the first 100 mUC patients treated with vinflunine at three Nordic cancer centers associated with the Nordic Urothelial Cancer Oncology Group...
August 2016: Oncology Letters
Niels Bonderup Dohn, Angela Fago, Johannes Overgaard, Peter Teglberg Madsen, Hans Malte
The laboratory has been given a central role in physiology education, and teachers report that it is motivating for students to undertake experimental work on live animals or measuring physiological responses on the students themselves. Since motivation is a critical variable for academic learning and achievement, then we must concern ourselves with questions that examine how students engage in laboratory work and persist at such activities. The purpose of the present study was to investigate how laboratory work influences student motivation in physiology...
September 2016: Advances in Physiology Education
Elisa Biasin, Tim Brandt van Driel, Kasper S Kjær, Asmus O Dohn, Morten Christensen, Tobias Harlang, Pavel Chabera, Yizhu Liu, Jens Uhlig, Mátyás Pápai, Zoltán Németh, Robert Hartsock, Winnie Liang, Jianxin Zhang, Roberto Alonso-Mori, Matthieu Chollet, James M Glownia, Silke Nelson, Dimosthenis Sokaras, Tadesse A Assefa, Alexander Britz, Andreas Galler, Wojciech Gawelda, Christian Bressler, Kelly J Gaffney, Henrik T Lemke, Klaus B Møller, Martin M Nielsen, Villy Sundström, György Vankó, Kenneth Wärnmark, Sophie E Canton, Kristoffer Haldrup
We study the structural dynamics of photoexcited [Co(terpy)_{2}]^{2+} in an aqueous solution with ultrafast x-ray diffuse scattering experiments conducted at the Linac Coherent Light Source. Through direct comparisons with density functional theory calculations, our analysis shows that the photoexcitation event leads to elongation of the Co-N bonds, followed by coherent Co-N bond length oscillations arising from the impulsive excitation of a vibrational mode dominated by the symmetrical stretch of all six Co-N bonds...
July 1, 2016: Physical Review Letters
Christina H Ruhlmann, Thomas Broe Christensen, Line Hammer Dohn, Merete Paludan, Eva Rønnengart, Ulrich Halekoh, Felix Hilpert, Petra Feyer, Gunnar Kristensen, Olfred Hansen, Dorothy Keefe, Jørn Herrstedt
BACKGROUND: The role of the neurokinin-1 (NK-1) receptor antagonists in the prevention of radiation-induced nausea and vomiting has not been established. The purpose of the GAND-emesis study was to investigate the efficacy and safety of fosaprepitant in combination with palonosetron and dexamethasone in the prevention of nausea and vomiting during 5 weeks of fractionated radiotherapy and concomitant weekly cisplatin in patients with cervical cancer. METHODS: This investigator initiated, multinational, randomised, double-blind, placebo-controlled phase 3 trial, included women with cervical cancer scheduled to receive fractionated radiotherapy and weekly cisplatin 40 mg/m(2) for 5 weeks...
April 2016: Lancet Oncology
Thomas J Caruso, Diane H Steinberg, Nancy Piro, Kimberly Walker, Rebecca Blankenburg, Caroline Rassbach, Juan L Marquez, Laurence Katznelson, Ann Dohn
BACKGROUND: Mentors influence medical trainees' experiences through career enhancement and psychosocial support, yet some trainees never receive benefits from involved mentors. OBJECTIVE: Our goals were to examine the effectiveness of 2 interventions aimed at increasing the number of mentors in training programs, and to assess group differences in mentor effectiveness, the relationship between trainees' satisfaction with their programs given the presence of mentors, and the relationship between the number of trainees with mentors and postgraduate year (PGY)...
February 2016: Journal of Graduate Medical Education
Kristoffer Haldrup, Wojciech Gawelda, Rafael Abela, Roberto Alonso-Mori, Uwe Bergmann, Amélie Bordage, Marco Cammarata, Sophie E Canton, Asmus O Dohn, Tim Brandt van Driel, David M Fritz, Andreas Galler, Pieter Glatzel, Tobias Harlang, Kasper S Kjær, Henrik T Lemke, Klaus B Møller, Zoltán Németh, Mátyás Pápai, Norbert Sas, Jens Uhlig, Diling Zhu, György Vankó, Villy Sundström, Martin M Nielsen, Christian Bressler
In liquid phase chemistry dynamic solute-solvent interactions often govern the path, ultimate outcome, and efficiency of chemical reactions. These steps involve many-body movements on subpicosecond time scales and thus ultrafast structural tools capable of capturing both intramolecular electronic and structural changes, and local solvent structural changes are desired. We have studied the intra- and intermolecular dynamics of a model chromophore, aqueous [Fe(bpy)3](2+), with complementary X-ray tools in a single experiment exploiting intense XFEL radiation as a probe...
February 18, 2016: Journal of Physical Chemistry. B
Huapeng H Yu, Michael R Dohn, Nicholas O Markham, Robert J Coffey, Albert B Reynolds
In vertebrate epithelia, p120-catenin (hereafter referred to as p120; also known as CTNND1) mediates E-cadherin stability and suppression of RhoA. Genetic ablation of p120 in various epithelial tissues typically causes striking alterations in tissue function and morphology. Although these effects could very well involve p120's activity towards Rho, ascertaining the impact of this relationship has been complicated by the fact that p120 is also required for cell-cell adhesion. Here, we have molecularly uncoupled p120's cadherin-stabilizing and RhoA-suppressing activites...
January 1, 2016: Journal of Cell Science
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