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Asmus O Dohn, Kasper S Kjær, Tobias B Harlang, Sophie E Canton, Martin M Nielsen, Klaus B Møller
This work provides a detailed mechanism for electron transfer in a heterodinuclear complex designed as a model system in which to study homogeneous molecular photocatalysis. With efficient Born-Oppenheimer molecular dynamics simulations, we show how intermediate, charge-separated states can mediate the electron transfer. We observe how Jahn-Teller distortion effects play out in solution, when the molecule has energetically close-lying states, and how this distortion is averaged out in the thermal sampling. Finally, we demonstrate how the solvent helps stabilize and localize the separated charge...
October 4, 2016: Inorganic Chemistry
S Krabbe, R Bolce, C H Brahe, U M Døhn, B J Ejbjerg, M L Hetland, E H Sasso, D Chernoff, M S Hansen, L S Knudsen, A Hansen, O R Madsen, M Hasselquist, J Møller, M Østergaard
OBJECTIVES: To investigate the multi-biomarker disease activity (MBDA) score by comparison with imaging findings in an investigator-initiated rheumatoid arthritis (RA) trial (HURRAH trial, NCT00696059). METHOD: Fifty-two patients with established RA initiated adalimumab treatment and had magnetic resonance imaging (MRI), ultrasonography (US), computed tomography (CT), and radiography performed at weeks 0, 26, and 52. Serum samples were analysed using MBDA score assays and associations between clinical measures, MBDA score, and imaging findings were investigated...
September 28, 2016: Scandinavian Journal of Rheumatology
Mads Ammitzbøll-Danielsen, Mikkel Østergaard, Viktoria Fana, Daniel Glinatsi, Uffe Møller Døhn, Lykke Midtbøll Ørnbjerg, Esperanza Naredo, Lene Terslev
OBJECTIVE: The aim of this study was to compare the efficacy of intramuscular versus ultrasound (US)-guided intratenosynovial glucocorticoid injection in providing disease control after 2, 4 and 12 weeks in patients with rheumatoid arthritis(RA) with tenosynovitis. METHODS: Fifty patients with RA and tenosynovitis were randomised into two double-blind groups: (A) 'intramuscular group', receiving intramuscular injection of betamethasone and US-guided intratenosynovial isotonic saline injection and (B) 'intratenosynovial group' receiving saline intramuscularly and US-guided intratenosynovial betamethasone injection...
September 7, 2016: Annals of the Rheumatic Diseases
Kristoffer Haldrup, Asmus O Dohn, Megan L Shelby, Michael W Mara, Andrew B Stickrath, Michael R Harpham, Jier Huang, Xiaoyi Zhang, Klaus B Møller, Arnab Chakraborty, Felix N Castellano, David M Tiede, Lin X Chen
Pyrazolate-bridged dinuclear Pt(II) complexes represent a series of molecules with tunable absorption and emission properties that can be directly modulated by structural factors, such as the Pt-Pt distance. However, direct experimental information regarding the structure of the emissive triplet excited state has remained scarce. Using time-resolved wide-angle X-ray scattering (WAXS), the excited triplet state molecular structure of [Pt(ppy)(μ-t-Bu2pz)]2 (ppy = 2-phenylpyridine; t-Bu2pz = 3,5-di-tert-butylpyrazolate), complex 1, was obtained in a dilute (0...
September 29, 2016: Journal of Physical Chemistry. A
Karin Holmsten, Line Dohn, Niels Viggo Jensen, Carl-Henrik Shah, Fredrik Jäderling, Helle Pappot, Anders Ullén
In 2009, vinflunine was introduced as a second-line treatment to be used after the failure of platinum therapy in patients with metastatic urothelial carcinoma (mUC). The present study investigated the administered vinflunine to patients with mUC in standard clinical practice with the aim of evaluating treatment patterns, response, survival parameters and side-effects. Data were collected retrospectively from the first 100 mUC patients treated with vinflunine at three Nordic cancer centers associated with the Nordic Urothelial Cancer Oncology Group...
August 2016: Oncology Letters
Niels Bonderup Dohn, Angela Fago, Johannes Overgaard, Peter Teglberg Madsen, Hans Malte
The laboratory has been given a central role in physiology education, and teachers report that it is motivating for students to undertake experimental work on live animals or measuring physiological responses on the students themselves. Since motivation is a critical variable for academic learning and achievement, then we must concern ourselves with questions that examine how students engage in laboratory work and persist at such activities. The purpose of the present study was to investigate how laboratory work influences student motivation in physiology...
September 2016: Advances in Physiology Education
Elisa Biasin, Tim Brandt van Driel, Kasper S Kjær, Asmus O Dohn, Morten Christensen, Tobias Harlang, Pavel Chabera, Yizhu Liu, Jens Uhlig, Mátyás Pápai, Zoltán Németh, Robert Hartsock, Winnie Liang, Jianxin Zhang, Roberto Alonso-Mori, Matthieu Chollet, James M Glownia, Silke Nelson, Dimosthenis Sokaras, Tadesse A Assefa, Alexander Britz, Andreas Galler, Wojciech Gawelda, Christian Bressler, Kelly J Gaffney, Henrik T Lemke, Klaus B Møller, Martin M Nielsen, Villy Sundström, György Vankó, Kenneth Wärnmark, Sophie E Canton, Kristoffer Haldrup
We study the structural dynamics of photoexcited [Co(terpy)_{2}]^{2+} in an aqueous solution with ultrafast x-ray diffuse scattering experiments conducted at the Linac Coherent Light Source. Through direct comparisons with density functional theory calculations, our analysis shows that the photoexcitation event leads to elongation of the Co-N bonds, followed by coherent Co-N bond length oscillations arising from the impulsive excitation of a vibrational mode dominated by the symmetrical stretch of all six Co-N bonds...
July 1, 2016: Physical Review Letters
Christina H Ruhlmann, Thomas Broe Christensen, Line Hammer Dohn, Merete Paludan, Eva Rønnengart, Ulrich Halekoh, Felix Hilpert, Petra Feyer, Gunnar Kristensen, Olfred Hansen, Dorothy Keefe, Jørn Herrstedt
BACKGROUND: The role of the neurokinin-1 (NK-1) receptor antagonists in the prevention of radiation-induced nausea and vomiting has not been established. The purpose of the GAND-emesis study was to investigate the efficacy and safety of fosaprepitant in combination with palonosetron and dexamethasone in the prevention of nausea and vomiting during 5 weeks of fractionated radiotherapy and concomitant weekly cisplatin in patients with cervical cancer. METHODS: This investigator initiated, multinational, randomised, double-blind, placebo-controlled phase 3 trial, included women with cervical cancer scheduled to receive fractionated radiotherapy and weekly cisplatin 40 mg/m(2) for 5 weeks...
April 2016: Lancet Oncology
Thomas J Caruso, Diane H Steinberg, Nancy Piro, Kimberly Walker, Rebecca Blankenburg, Caroline Rassbach, Juan L Marquez, Laurence Katznelson, Ann Dohn
BACKGROUND: Mentors influence medical trainees' experiences through career enhancement and psychosocial support, yet some trainees never receive benefits from involved mentors. OBJECTIVE: Our goals were to examine the effectiveness of 2 interventions aimed at increasing the number of mentors in training programs, and to assess group differences in mentor effectiveness, the relationship between trainees' satisfaction with their programs given the presence of mentors, and the relationship between the number of trainees with mentors and postgraduate year (PGY)...
February 2016: Journal of Graduate Medical Education
Kristoffer Haldrup, Wojciech Gawelda, Rafael Abela, Roberto Alonso-Mori, Uwe Bergmann, Amélie Bordage, Marco Cammarata, Sophie E Canton, Asmus O Dohn, Tim Brandt van Driel, David M Fritz, Andreas Galler, Pieter Glatzel, Tobias Harlang, Kasper S Kjær, Henrik T Lemke, Klaus B Møller, Zoltán Németh, Mátyás Pápai, Norbert Sas, Jens Uhlig, Diling Zhu, György Vankó, Villy Sundström, Martin M Nielsen, Christian Bressler
In liquid phase chemistry dynamic solute-solvent interactions often govern the path, ultimate outcome, and efficiency of chemical reactions. These steps involve many-body movements on subpicosecond time scales and thus ultrafast structural tools capable of capturing both intramolecular electronic and structural changes, and local solvent structural changes are desired. We have studied the intra- and intermolecular dynamics of a model chromophore, aqueous [Fe(bpy)3](2+), with complementary X-ray tools in a single experiment exploiting intense XFEL radiation as a probe...
February 18, 2016: Journal of Physical Chemistry. B
Huapeng H Yu, Michael R Dohn, Nicholas O Markham, Robert J Coffey, Albert B Reynolds
In vertebrate epithelia, p120-catenin (hereafter referred to as p120; also known as CTNND1) mediates E-cadherin stability and suppression of RhoA. Genetic ablation of p120 in various epithelial tissues typically causes striking alterations in tissue function and morphology. Although these effects could very well involve p120's activity towards Rho, ascertaining the impact of this relationship has been complicated by the fact that p120 is also required for cell-cell adhesion. Here, we have molecularly uncoupled p120's cadherin-stabilizing and RhoA-suppressing activites...
January 1, 2016: Journal of Cell Science
D E Amanoel, D T Thomas, D Blache, J T B Milton, M G Wilmot, D K Revell, H C Norman
Given the capacity of ruminants to modify diet selection based on metabolic needs, we hypothesised that, when given a choice, lambs experiencing a vitamin E deficiency would consume more of a vitamin E-enriched feed than lambs not deficient in vitamin E. Fifty-six Dohne Merino lambs were divided into two groups and fed either a vitamin E-deficient diet over 40 days to induce low plasma vitamin E or a vitamin E-enriched diet to induce high plasma vitamin E. The lambs were then offered a choice of vitamin E-enriched and vitamin E-deficient pellets...
February 2016: Animal: An International Journal of Animal Bioscience
Line Hammer Dohn, Helle Pappot, Benedikte Richter Iversen, Martin Illemann, Gunilla Høyer-Hansen, Ib Jarle Christensen, Peter Thind, Lisbeth Salling, Hans von der Maase, Ole Didrik Laerum
The objective of the present study was to confirm the expression and localisation pattern of the urokinase-type plasminogen activator receptor (uPAR) focusing on its possible clinical relevance in patients with urothelial neoplasia of the bladder. uPAR is a central molecule in tissue remodelling during cancer invasion and metastasis and is an established prognostic marker in various cancer diseases other than bladder cancer. Formalin-fixed and paraffin-embedded tumour-tissue blocks from 186 patients treated with radical cystectomy were analysed...
2015: PloS One
Rikke V Nielsen, Hanna Siegel, Jonna S Fomsgaard, Johnny D H Andersen, Robertas Martusevicius, Ole Mathiesen, Jørgen B Dahl
Glucocorticoids have attracted increasing attention as adjuvants in the treatment of acute postoperative pain. Furthermore, anecdotal reports may support glucocorticoids for preventing sustained postoperative pain. We explored preoperative dexamethasone combined with paracetamol and ibuprofen on acute and sustained pain after lumbar disk surgery. In this blinded study, 160 patients undergoing lumbar disk surgery were randomly assigned to 16 mg IV dexamethasone or placebo. All patients received perioperative paracetamol and ibuprofen, and postoperative IV patient-controlled analgesia with morphine...
December 2015: Pain
Neeraj Sethi
The facial plastic surgeon potentially has a conflict of interest when confronted with the patients requesting surgery, due to the personal gain attainable by agreeing to perform surgery. The aim of this review is to discuss the potential harm the surgeon can inflict by carrying out facial plastic surgery, beyond the standard surgical complications of infection or bleeding. It will discuss the desire for self-improvement and perfection and increase in the prevalence facial plastic surgery. We address the principles of informed consent, beneficence and non-maleficence, as well as justice and equality and how the clinician who undertakes facial plastic surgery is at risk of breaching these principles without due care and diligence...
September 2016: European Archives of Oto-rhino-laryngology
Marlize Z Viviers, Jan P I Bekker, Barend V Burger, Niel J le Roux, John Morris, Maritha le Roux
Amniotic fluid (AF) was investigated as a possible source of the neonatal recognition cue that plays a crucial role in ewe-lamb bonding in sheep. A total of 70 of the 133 volatile organic compounds (VOCs), previously identified in the cranial wool of neonatal Dohne Merino lambs, was also identified in AF collected individually from neonatal twins. As in the case of the wool of neonatal lambs, the VOC profiles (GC-MS) of the AF of twins were remarkably similar. However, the VOC profiles of the AF differed from that of the wool VOCs of the same lambs...
2015: Zeitschrift Für Naturforschung. C, A Journal of Biosciences
Hanna Siegel, Johnny Dohn Holmgren Andersen, Rikke Vibeke Nielsen, Kristian Lorentzen, Karsten Skovgaard Olsen
No abstract text is available yet for this article.
February 2016: European Journal of Anaesthesiology
Trisha Thunker-Dohn
No abstract text is available yet for this article.
2015: South Dakota Medicine: the Journal of the South Dakota State Medical Association
György Vankó, Amélie Bordage, Mátyás Pápai, Kristoffer Haldrup, Pieter Glatzel, Anne Marie March, Gilles Doumy, Alexander Britz, Andreas Galler, Tadesse Assefa, Delphine Cabaret, Amélie Juhin, Tim B van Driel, Kasper S Kjær, Asmus Dohn, Klaus B Møller, Henrik T Lemke, Erik Gallo, Mauro Rovezzi, Zoltán Németh, Emese Rozsályi, Tamás Rozgonyi, Jens Uhlig, Villy Sundström, Martin M Nielsen, Linda Young, Stephen H Southworth, Christian Bressler, Wojciech Gawelda
Theoretical predictions show that depending on the populations of the Fe 3d xy , 3d xz , and 3d yz orbitals two possible quintet states can exist for the high-spin state of the photoswitchable model system [Fe(terpy)2](2+). The differences in the structure and molecular properties of these (5)B2 and (5)E quintets are very small and pose a substantial challenge for experiments to resolve them. Yet for a better understanding of the physics of this system, which can lead to the design of novel molecules with enhanced photoswitching performance, it is vital to determine which high-spin state is reached in the transitions that follow the light excitation...
March 19, 2015: Journal of Physical Chemistry. C, Nanomaterials and Interfaces
Sophie E Canton, Kasper S Kjær, György Vankó, Tim B van Driel, Shin-ichi Adachi, Amélie Bordage, Christian Bressler, Pavel Chabera, Morten Christensen, Asmus O Dohn, Andreas Galler, Wojciech Gawelda, David Gosztola, Kristoffer Haldrup, Tobias Harlang, Yizhu Liu, Klaus B Møller, Zoltán Németh, Shunsuke Nozawa, Mátyás Pápai, Tokushi Sato, Takahiro Sato, Karina Suarez-Alcantara, Tadashi Togashi, Kensuke Tono, Jens Uhlig, Dimali A Vithanage, Kenneth Wärnmark, Makina Yabashi, Jianxin Zhang, Villy Sundström, Martin M Nielsen
Ultrafast photoinduced electron transfer preceding energy equilibration still poses many experimental and conceptual challenges to the optimization of photoconversion since an atomic-scale description has so far been beyond reach. Here we combine femtosecond transient optical absorption spectroscopy with ultrafast X-ray emission spectroscopy and diffuse X-ray scattering at the SACLA facility to track the non-equilibrated electronic and structural dynamics within a bimetallic donor-acceptor complex that contains an optically dark centre...
2015: Nature Communications
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