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https://www.readbyqxmd.com/read/29862043/definitions-and-reliability-assessment-of-elementary-ultrasound-lesions-in-giant-cell-arteritis-a-study-from-the-omeract-large-vessel-vasculitis-ultrasound-working-group
#1
Stavros Chrysidis, Christina Duftner, Christian Dejaco, Valentin S Schäfer, Sofia Ramiro, Greta Carrara, Carlo Alberto Scirè, Alojzija Hocevar, Andreas P Diamantopoulos, Annamaria Iagnocco, Chetan Mukhtyar, Cristina Ponte, Esperanza Naredo, Eugenio De Miguel, George A Bruyn, Kenneth J Warrington, Lene Terslev, Marcin Milchert, Maria Antonietta D'Agostino, Mattew J Koster, Naina Rastalsky, Petra Hanova, Pierluigi Macchioni, Tanaz A Kermani, Tove Lorenzen, Uffe Møller Døhn, Ulrich Fredberg, Wolfgang Hartung, Bhaskar Dasgupta, Wolfgang A Schmidt
Objectives: To define the elementary ultrasound (US) lesions in giant cell arteritis (GCA) and to evaluate the reliability of the assessment of US lesions according to these definitions in a web-based reliability exercise. Methods: Potential definitions of normal and abnormal US findings of temporal and extracranial large arteries were retrieved by a systematic literature review. As a subsequent step, a structured Delphi exercise was conducted involving an expert panel of the Outcome Measures in Rheumatology (OMERACT) US Large Vessel Vasculitis Group to agree definitions of normal US appearance and key elementary US lesions of vasculitis of temporal and extracranial large arteries...
2018: RMD Open
https://www.readbyqxmd.com/read/29605579/noninvasive-stimulation-of-the-ventromedial-prefrontal-cortex-modulates-emotional-face-processing
#2
Constantin Winker, Maimu A Rehbein, Dean Sabatinelli, Mira Dohn, Julius Maitzen, Carsten H Wolters, Volker Arolt, Markus Junghofer
The ventromedial prefrontal cortex (vmPFC) is associated with emotional states that can be characterized as positive affect. Moreover, a variety of psychiatric disorders that are associated with disturbed reactions toward reward- or safety-signaling stimuli reveal functional or structural anomalies within this area. Thus, neuromodulation of this region via transcranial direct current stimulation (tDCS) offers an attractive opportunity to noninvasively influence pleasant emotional and reward processing. Recent experiments revealed hemodynamic and electrophysiological evidence for valence specific modulations of emotional scene processing after excitatory and inhibitory tDCS of the vmPFC...
July 15, 2018: NeuroImage
https://www.readbyqxmd.com/read/29569762/ndrg1-and-foxo1-regulate-endothelial-cell-proliferation-in-infantile-hemangioma
#3
Ji Won Byun, Hye Young An, Seung Dohn Yeom, Seok Jong Lee, Ho Yun Chung
The etiopathogenesis of infantile hemangioma has not been well understood, and it is accepted that angiogenic mediator dysregulation is the main contributor to the abnormal hemangioma capillary formation. The role of NDRG1, a hypoxia-inducible protein; FOXOs, which are tumor suppressor proteins; and the mTOR complex 2 pathway in infantile hemangioma have not been studied yet. The purpose of this study was to investigate NDRG1 and FOXO1 expression in the infantile hemangioma and the correlation of these proteins with proliferation and involution...
March 23, 2018: Experimental Dermatology
https://www.readbyqxmd.com/read/29551847/perspectives-of-youth-in-foster-care-on-essential-ingredients-for-promoting-self-determination-and-successful-transition-to-adult-life-my-life-model
#4
Laurie E Powers, Ann Fullerton, Jessica Schmidt, Sarah Geenen, Molly Oberweiser-Kennedy, JoAnn Dohn, May Nelson, Rosemary Iavanditti, Jennifer Blakeslee
Research clearly documents the serious challenges and poor outcomes experienced by many young people exiting foster care, as well as compounded disparities for the high percentage of youth in care who are identified with disabilities and/or mental health challenges. However, very little research has been conducted to specify or validate effective models for improving the transition trajectories of youth exiting care. Evidence suggests the My Life self-determination enhancement model offers a promising approach for supporting youths' self-determined and positive transition to adulthood...
February 2018: Children and Youth Services Review
https://www.readbyqxmd.com/read/29488907/anisotropy-enhanced-x-ray-scattering-from-solvated-transition-metal-complexes
#5
Elisa Biasin, Tim B van Driel, Gianluca Levi, Mads G Laursen, Asmus O Dohn, Asbjørn Moltke, Peter Vester, Frederik B K Hansen, Kasper S Kjaer, Tobias Harlang, Robert Hartsock, Morten Christensen, Kelly J Gaffney, Niels E Henriksen, Klaus B Møller, Kristoffer Haldrup, Martin M Nielsen
Time-resolved X-ray scattering patterns from photoexcited molecules in solution are in many cases anisotropic at the ultrafast time scales accessible at X-ray free-electron lasers (XFELs). This anisotropy arises from the interaction of a linearly polarized UV-Vis pump laser pulse with the sample, which induces anisotropic structural changes that can be captured by femtosecond X-ray pulses. In this work, a method for quantitative analysis of the anisotropic scattering signal arising from an ensemble of molecules is described, and it is demonstrated how its use can enhance the structural sensitivity of the time-resolved X-ray scattering experiment...
March 1, 2018: Journal of Synchrotron Radiation
https://www.readbyqxmd.com/read/29318731/absence-of-the-drosophila-jump-muscle-actin-act79b-is-compensated-by-up-regulation-of-act88f
#6
Tracy E Dohn, Richard M Cripps
BACKGROUND: Actins are structural components of the cytoskeleton and muscle, and numerous actin isoforms are found in most organisms. However, many actin isoforms are expressed in distinct patterns allowing each actin to have a specialized function. Numerous studies have demonstrated that actin isoforms both can and cannot compensate for each other under specific circumstances. This allows for an ambiguity of whether isoforms are functionally distinct. RESULTS: In this study, we analyzed mutants of Drosophila Act79B, the predominant actin expressed in the adult jump muscle...
April 2018: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/29157563/nr2f1a-balances-atrial-chamber-and-atrioventricular-canal-size-via-bmp-signaling-independent-and-dependent-mechanisms
#7
Tiffany B Duong, Padmapriyadarshini Ravisankar, Yuntao Charlie Song, Jacob T Gafranek, Ariel B Rydeen, Tracy E Dohn, Lindsey A Barske, J Gage Crump, Joshua S Waxman
Determination of appropriate chamber size is critical for normal vertebrate heart development. Although Nr2f transcription factors promote atrial maintenance and differentiation, how they determine atrial size remains unclear. Here, we demonstrate that zebrafish Nr2f1a is expressed in differentiating atrial cardiomyocytes. Zebrafish nr2f1a mutants have smaller atria due to a specific reduction in atrial cardiomyocyte (AC) number, suggesting it has similar requirements to Nr2f2 in mammals. Furthermore, the smaller atria in nr2f1a mutants are derived from distinct mechanisms that perturb AC differentiation at the chamber poles...
February 1, 2018: Developmental Biology
https://www.readbyqxmd.com/read/29130932/p120-catenin-is-an-obligate-haploinsufficient-tumor-suppressor-in-intestinal-neoplasia
#8
Sarah P Short, Jumpei Kondo, Whitney G Smalley-Freed, Haruna Takeda, Michael R Dohn, Anne E Powell, Robert H Carnahan, Mary K Washington, Manish Tripathi, D Michael Payne, Nancy A Jenkins, Neal G Copeland, Robert J Coffey, Albert B Reynolds
p120-Catenin (p120) functions as a tumor suppressor in intestinal cancer, but the mechanism is unclear. Here, using conditional p120 knockout in Apc-sensitized mouse models of intestinal cancer, we have identified p120 as an "obligatory" haploinsufficient tumor suppressor. Whereas monoallelic loss of p120 was associated with a significant increase in tumor multiplicity, loss of both alleles was never observed in tumors from these mice. Moreover, forced ablation of the second allele did not further enhance tumorigenesis, but instead induced synthetic lethality in combination with Apc loss of heterozygosity...
December 1, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29083921/a-gpaw-implementation-of-qm-mm-electrostatic-embedding-and-application-to-a-solvated-diplatinum-complex
#9
Asmus O Dohn, Elvar Örn Jónsson, Gianluca Levi, Jens Jørgen Mortensen, Olga Lopez-Acevedo, Kristian S Thygesen, Karsten W Jacobsen, Jens Ulstrup, Niels E Henriksen, Klaus Braagaard Moller, Hannes Jonsson
A multiscale DFT-QM/MM scheme is presented, based on an efficient electrostatic coupling between the electronic density obtained from a Grid-based Projector Augmented Wave (GPAW) implementation of density functional theory and a classical potential energy function. The scheme is implemented in a general fashion and can be used with various choices for the descriptions of the QM or MM regions. Tests on H2O clusters, ranging from dimer to decamer show that no systematic energy errors are introduced by the coupling that exceeds the differences in the QM and MM descriptions...
October 30, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/29057127/heat-stroke-a-medical-emergency-appearing-in-new-regions
#10
Sofie Søndergaard Mørch, Johnny Dohn Holmgren Andersen, Morten Heiberg Bestle
Heat stroke is an acute, life-threatening emergency characterized clinically by elevated body temperature and central nervous system dysfunction. Early recognition and treatment including aggressive cooling and management of life-threatening systemic complications are essential to reduce morbidity and mortality. This case report describes two Danish patients diagnosed with heat stroke syndrome during a heat wave in the summer of 2014. Both patients were morbidly obese and had several predisposing illnesses...
2017: Case Reports in Critical Care
https://www.readbyqxmd.com/read/29038237/the-gain-of-function-integrin-%C3%AE-3-pro33-variant-alters-the-serotonin-system-in-the-mouse-brain
#11
Michael R Dohn, Christopher G Kooker, Lisa Bastarache, Tammy Jessen, Capria Rinaldi, Seth Varney, Matthew D Mazalouskas, Hope Pan, Kendra H Oliver, Digna R Velez Edwards, James S Sutcliffe, Joshua C Denny, Ana M D Carneiro
Engagement of integrins by the extracellular matrix initiates signaling cascades that drive a variety of cellular functions, including neuronal migration and axonal pathfinding in the brain. Multiple lines of evidence link the ITGB3 gene encoding the integrin β3 subunit with the serotonin (5-HT) system, likely via its modulation of the 5-HT transporter (SERT). The ITGB3 coding polymorphism Leu33Pro (rs5918, PlA2 ) produces hyperactive αvβ3 receptors that influence whole-blood 5-HT levels and may influence the risk for autism spectrum disorder (ASD)...
November 15, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28990021/ultrafast-x-ray-absorption-study-of-longitudinal-transverse-phonon-coupling-in-electrolyte-aqueous-solution
#12
Yishuo Jiao, Bernhard W Adams, Asmus Ougaard Dohn, Klaus B Møller, Hannes Jónsson, Christoph Rose-Petruck
Ultrafast X-ray absorption spectroscopy is applied to study the conversion of longitudinal to transverse phonons in aqueous solution. Permanganate solutes serve as X-ray probe molecules that permit the measurement of the conversion of 13.5 GHz, longitudinal phonons to 27 GHz, transverse phonons that propagate with high-frequency sound speed. The experimental results, combined with QM/MM MD simulations, show that the hydrogen bond network around the charged solutes has a glass-like stiffness that persists for at least tens of picoseconds...
October 18, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28966522/histiocytoid-sweet-syndrome-in-a-child-without-underlying-systemic-disease
#13
Seung Dohn Yeom, Hye Soo Ko, Jong Hyuk Moon, Min Ji Kang, Ji Won Byun, Gwang Seong Choi, Jeonghyun Shin
Sweet syndrome (acute, febrile, neutrophilic dermatosis) is characterized by the acute onset of an eruption of painful nodules or erythematous or violaceous plaques on the limbs, face and neck. These symptoms are accompanied by fever. The diagnostic features include histopathological findings of dermal neutrophilic infiltration without leukocytoclastic vasculitis or peripheral blood leukocytosis. Sweet syndrome is associated with infection, malignancies, autoimmune disease, pregnancy, and drugs. Patients with Sweet syndrome demonstrate a complete and rapid response to systemic steroid administration...
October 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28789764/-treatment-of-hyperthermia
#14
Sofie Søndergaard Mørch, Johnny Dohn Holmgren Andersen, Morten Heiberg Bestle
Hyperthermia is an uncontrolled elevation of body temperature exceeding the body's ability to dissipate heat. Hyperthermia can result in dangerously high core temperatures and can rapidly become fatal. Common causes include heat stroke, malignant hyperthermia, serotonin syndrome, neuroleptic syndrome, a few endocrine emergencies as well as numerous intoxications. Rapid diagnosis and prompt cooling are pivotal, since the condition triggers a cascade of metabolic events which may progress to irreversible injury or death...
July 24, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28728567/settings-and-artefacts-relevant-for-doppler-ultrasound-in-large-vessel-vasculitis
#15
REVIEW
L Terslev, A P Diamantopoulos, U Møller Døhn, W A Schmidt, S Torp-Pedersen
Ultrasound is used increasingly for diagnosing large vessel vasculitis (LVV). The application of Doppler in LVV is very different from in arthritic conditions. This paper aims to explain the most important Doppler parameters, including spectral Doppler, and how the settings differ from those used in arthritic conditions and provide recommendations for optimal adjustments. This is addressed through relevant Doppler physics, focusing, for example, on the Doppler shift equation and how angle correction ensures correctly displayed blood velocity...
July 20, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28693480/utility-preserving-anonymization-for-health-data-publishing
#16
Hyukki Lee, Soohyung Kim, Jong Wook Kim, Yon Dohn Chung
BACKGROUND: Publishing raw electronic health records (EHRs) may be considered as a breach of the privacy of individuals because they usually contain sensitive information. A common practice for the privacy-preserving data publishing is to anonymize the data before publishing, and thus satisfy privacy models such as k-anonymity. Among various anonymization techniques, generalization is the most commonly used in medical/health data processing. Generalization inevitably causes information loss, and thus, various methods have been proposed to reduce information loss...
July 11, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28588741/erratum-vinflunine-treatment-in-patients-with-metastatic-urothelial-cancer-a-nordic-retrospective-multicenter-analysis
#17
Karin Holmsten, Line Dohn, Niels Viggo Jensen, Carl-Henrik Shah, Fredrik Jäderling, Helle Pappot, Anders Ullén
[This corrects the article DOI: 10.3892/ol.2016.4775.].
June 2017: Oncology Letters
https://www.readbyqxmd.com/read/28570068/solvent-controlled-chemoselectivity-in-the-photolytic-release-of-hydroxamic-acids-and-carboxamides-from-solid-support
#18
Katrine Qvortrup, Rico G Petersen, Asmus O Dohn, Klaus B Møller, Thomas E Nielsen
The synthetic utility and theoretical basis of a photolabile hydroxylamine-linker are presented. The developed protocols enable the efficient synthesis and chemoselective photolytic release of either hydroxamates or carboxamides from solid support. The bidetachable mode of the linker unit is uniquely dependent on the solvent. Hydroxamic acids are obtained by performing photolysis in protic solvents, whereas photolysis in aprotic solvents enables the selective release of carboxamides.
June 1, 2017: Organic Letters
https://www.readbyqxmd.com/read/27919391/privacy-preserving-data-cube-for-electronic-medical-records-an-experimental-evaluation
#19
Soohyung Kim, Hyukki Lee, Yon Dohn Chung
INTRODUCTION: The aim of this study is to evaluate the effectiveness and efficiency of privacy-preserving data cubes of electronic medical records (EMRs). An EMR data cube is a complex of EMR statistics that are summarized or aggregated by all possible combinations of attributes. Data cubes are widely utilized for efficient big data analysis and also have great potential for EMR analysis. For safe data analysis without privacy breaches, we must consider the privacy preservation characteristics of the EMR data cube...
January 2017: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/27892472/atomistic-characterization-of-the-active-site-solvation-dynamics-of-a-model-photocatalyst
#20
Tim B van Driel, Kasper S Kjær, Robert W Hartsock, Asmus O Dohn, Tobias Harlang, Matthieu Chollet, Morten Christensen, Wojciech Gawelda, Niels E Henriksen, Jong Goo Kim, Kristoffer Haldrup, Kyung Hwan Kim, Hyotcherl Ihee, Jeongho Kim, Henrik Lemke, Zheng Sun, Villy Sundström, Wenkai Zhang, Diling Zhu, Klaus B Møller, Martin M Nielsen, Kelly J Gaffney
The interactions between the reactive excited state of molecular photocatalysts and surrounding solvent dictate reaction mechanisms and pathways, but are not readily accessible to conventional optical spectroscopic techniques. Here we report an investigation of the structural and solvation dynamics following excitation of a model photocatalytic molecular system [Ir2(dimen)4](2+), where dimen is para-diisocyanomenthane. The time-dependent structural changes in this model photocatalyst, as well as the changes in the solvation shell structure, have been measured with ultrafast diffuse X-ray scattering and simulated with Born-Oppenheimer Molecular Dynamics...
November 28, 2016: Nature Communications
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