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https://www.readbyqxmd.com/read/28918288/th9-cells-promote-antitumor-immunity-via-il-9-and-il-21-and-demonstrate-atypical-cytokine-expression-in-breast-cancer
#1
Fa-Ping You, Jian Zhang, Tao Cui, Rui Zhu, Chong-Qing Lv, Hai-Tao Tang, Di-Wen Sun
Breast cancer is a major cause of cancer-related death in women. Antitumor T cell responses play critical therapeutic roles, including direct cytotoxicity mediated by CD8(+) T cells and immunomodulatory roles mediated by CD4(+) T cells. The IL-9-expressing Th9 cells are recently found to present antitumor immunity in melanoma and lung adenocarcinoma. In this study, we found that IL-9 expression in the serum and in circulating CD4(+) T cells were significantly upregulated in breast cancer patients compared to healthy controls...
September 14, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28918186/health-related-quality-of-life-in-melanoma-patients-impact-of-melanoma-related-limb-lymphoedema
#2
Caroline A Gjorup, Mogens Groenvold, Helle W Hendel, Karin Dahlstroem, Krzysztof T Drzewiecki, Tobias W Klausen, Lisbet R Hölmich
AIM: To explore health-related quality of life (HRQoL) in recurrence-free melanoma patients, with a focus on the association between melanoma-related limb lymphoedema and HRQoL. METHODS: HRQoL was evaluated using the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30), the breast cancer module (EORTC QLQ-BR23) subscales body image and future perspective, the Functional Assessment for Cancer Therapy-General subscale social/family well-being and the Hospital Anxiety and Depression Scale...
September 14, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28916526/monoclonal-antibodies-directed-against-cadherin-rgd-exhibit-therapeutic-activity-against-melanoma-and-colorectal-cancer-metastasis
#3
Ruben A Bartolomé, Carmen Aizpurua, Marta Jaén, Sofia Torres, Eva Calviño, Juan I Imbaud, J Ignacio Casal
PURPOSE: New targets are required for the control of advanced metastatic disease. We investigated the use of cadherin RGD motifs, which activate the α2β1integrin pathway, as targets for the development of therapeutic monoclonal antibodies (mAbs). EXPERIMENTAL DESIGN: CDH17 fragments and peptides were prepared and used for immunization and antibody development. Antibodies were tested for inhibition of β1 integrin and cell adhesion, proliferation and invasion assays using cell lines from different cancer types: colorectal, pancreatic, melanoma and breast cancer...
September 15, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28914692/increasing-suicide-risk-among-cancer-patients-in-lithuania-from-1993-to-2012-a-cancer-registry-based-study
#4
Auguste Kaceniene, Agne Krilaviciute, Jurgita Kazlauskiene, Giedre Bulotiene, Giedre Smailyte
Certain groups of individuals seem to have an increased risk of committing suicide, and a number of studies have reported an increased risk of suicide among cancer patients. In this study, we aim to estimate the risk of suicide among cancer patients in Lithuania over the period 1993-2012. The records of patients diagnosed with primary cancer were extracted from the population-based Lithuanian Cancer Registry and 273 511 cases of first cancer were included in the analysis. Sex, age and calendar period-standardized mortality ratios (SMRs) were calculated by dividing the observed numbers of suicides among cancer patients by the expected number using national rates...
September 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28912897/genomic-analysis-of-tumor-microenvironment-immune-types-across-14-solid-cancer-types-immunotherapeutic-implications
#5
Yu-Pei Chen, Yu Zhang, Jia-Wei Lv, Ying-Qin Li, Ya-Qin Wang, Qing-Mei He, Xiao-Jing Yang, Ying Sun, Yan-Ping Mao, Jing-Ping Yun, Na Liu, Jun Ma
We performed a comprehensive immuno-genomic analysis of tumor microenvironment immune types (TMITs), which is classified into four groups based on PD-L1+CD8A or PD-L1+cytolytic activity (CYT) expression, across a broad spectrum of solid tumors in order to help identify patients who will benefit from anti- PD-1/PD-L1 therapy. The mRNA sequencing data from The Cancer Genome Atlas (TCGA) of 14 solid cancer types representing 6,685 tumor samples was analyzed. TMIT was classified only for those tumor types that both PD-L1 and CD8A/CYT could prefict mutation and/or neoantigen number...
2017: Theranostics
https://www.readbyqxmd.com/read/28898233/estimating-the-impact-of-a-cancer-diagnosis-on-life-expectancy-by-socio-economic-group-for-a-range-of-cancer-types-in-england
#6
Elisavet Syriopoulou, Hannah Bower, Therese M-L Andersson, Paul C Lambert, Mark J Rutherford
BACKGROUND: Differences in cancer survival exist across socio-economic groups for many cancer types. Standard metrics fail to show the overall impact for patients and the population. METHODS: The available data consist of a population of ∼2.5 million patients and include all patients recorded as being diagnosed with melanoma, prostate, bladder, breast, colon, rectum, lung, ovarian and stomach cancers in England between 1998 and 2013. We estimated the average loss in expectation of life per patient in years and the proportion of life lost for a range of cancer types, separately by deprivation group...
September 12, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28890814/outcomes-and-complications-of-radiation-therapy-in-patients-with-familial-adenomatous-polyposis
#7
Meng Gan, Dustin Boothe, Deborah W Neklason, N Jewel Samadder, Jonathan Frandsen, Megan B Keener, Shane Lloyd
BACKGROUND: The outcomes, complications, and rates of secondary malignancies from radiation therapy (RT) are not known for patients with familial adenomatous polyposis (FAP). METHODS: We queried the Hereditary Gastrointestinal Cancer Registry (HGCR) for patients with FAP who received RT. Outcomes assessed included acute and late treatment toxicity and secondary malignancies. RESULTS: We identified 15 patients undergoing 18 treatment courses...
August 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28890195/gk-1-peptide-reduces-tumor-growth-decreases-metastatic-burden-and-increases-survival-in-a-murine-breast-cancer-model
#8
D Torres-García, A Pérez-Torres, K Manoutcharian, U Orbe, R Servín-Blanco, G Fragoso, E Sciutto
GK-1 is a parasite-derived peptide adjuvant of 18 amino acid-length that enhances T-cell function and increases survival in B16-F10 melanoma tumor-bearing mice. This study was designed to evaluate in vivo the antitumor efficacy of GK-1 on 4T1 mouse mammary carcinoma. BALB/c mice with palpable primary tumors were weekly intravenously injected three times with saline solution or three different concentrations (10, 50, or 100μg per mouse) of GK-1. GK-1 significantly increased lifespan (p<0.0001) and reduced the primary tumor weight (p=0...
September 7, 2017: Vaccine
https://www.readbyqxmd.com/read/28885865/changes-in-insurance-coverage-and-stage-at-diagnosis-among-nonelderly-patients-with-cancer-after-the-affordable-care-act
#9
Ahmedin Jemal, Chun Chieh Lin, Amy J Davidoff, Xuesong Han
Purpose To examine change in the percent uninsured and early-stage diagnosis among nonelderly patients with newly diagnosed cancer after the Affordable Care Act (ACA). Patients and Methods By using the National Cancer Data Base, we estimated absolute change (APC) and relative change in percent uninsured among patients with newly diagnosed cancer age 18 to 64 years between 2011 to the third quarter of 2013 (pre-ACA implementation) and the second to fourth quarter of 2014 (post-ACA) in Medicaid expansion and nonexpansion states by family income level...
September 8, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28883519/monolithic-chip-for-high-throughput-blood-cell-depletion-to-sort-rare-circulating-tumor-cells
#10
Fabio Fachin, Philipp Spuhler, Joseph M Martel-Foley, Jon F Edd, Thomas A Barber, John Walsh, Murat Karabacak, Vincent Pai, Melissa Yu, Kyle Smith, Henry Hwang, Jennifer Yang, Sahil Shah, Ruby Yarmush, Lecia V Sequist, Shannon L Stott, Shyamala Maheswaran, Daniel A Haber, Ravi Kapur, Mehmet Toner
Circulating tumor cells (CTCs) are a treasure trove of information regarding the location, type and stage of cancer and are being pursued as both a diagnostic target and a means of guiding personalized treatment. Most isolation technologies utilize properties of the CTCs themselves such as surface antigens (e.g., epithelial cell adhesion molecule or EpCAM) or size to separate them from blood cell populations. We present an automated monolithic chip with 128 multiplexed deterministic lateral displacement devices containing ~1...
September 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28881846/safety-and-efficacy-of-p62-dna-vaccine-elenagen-in-a-first-in-human-trial-in-patients-with-advanced-solid-tumors
#11
Dmitry M Ponomarenko, Irina D Klimova, Yulia A Chapygina, Viktoria V Dvornichenko, Natalia V Zhukova, Rashida V Orlova, Georgy M Manikhas, Alexandr V Zyryanov, Lilya A Burkhanova, Irina I Badrtdinova, Basile N Oshchepkov, Elena V Filippova, Sergei V Orlov, Sergei I Kolesnikov, Albert A Sufianov, Svetlana R Baum, Olga Y Zaitzeva, Andrey B Komissarov, Mikhail P Grudinin, Oleg I Kiselev, Anatoly F Tsyb, Franco Venanzi, Vita Shcherbinina, Andrey Chursov, Vladimir L Gabai, Alexander M Shneider
Elenagen is a plasmid encoding p62/SQSTM1, the first DNA vaccine possessing two mutually complementing mechanisms of action: it elicits immune response against p62 and mitigates systemic chronic inflammation. Previously, Elenagen demonstrated anti-tumor efficacy and safety in rodent tumor models and spontaneous tumors in dogs. This multicenter I/IIa trial evaluated safety and clinical activity of Elenagen in patients with advanced solid tumors. Fifteen patients were treated with escalating doses of Elenagen (1- 5 mg per doses, 5 times weekly) and additional 12 patients received 1 mg dose...
August 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28868024/isolated-splenic-metastasis-from-non-small-cell-lung-cancer-a-case-report-and-review-of-the-literature
#12
Nikolaos Mitsimponas, Maria Mitsogianni, Felipe Crespo, Karl-Axel Hartmann, Stefan Diederich, Bernd Klosterhalfen, Aristoteles Giagounidis
Metastases to the spleen are rare but have been reported for different tumor entities, including breast cancer, lung cancer, colorectal cancer, ovarian cancer, and melanoma. As an isolated event, splenic metastasis from non-small-cell lung cancer (NSCLC) is exceedingly rare. Until now, only 28 cases have been reported in the medical literature. We report the case of a 66-year-old woman with NSCLC (adenocarcinoma) who presented with a synchronous, isolated splenic metastasis. Operative removal of both primary tumor and metastasis was not possible due to multiple comorbidities...
May 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/28856087/complications-of-bone-metastases-from-malignant-melanoma
#13
Jamal Zekri, Maria Marples, Dominic Taylor, Kiran Kandukurti, Lucy McParland, Janet E Brown
INTRODUCTION: Metastatic bone disease (MBD) carries significant morbidity for patients with cancer. MBD from malignant melanoma (MM) is understudied. We examined the characteristics, morbidity, management and outcome of MBD in patients with MM. METHODS: Patients with metastatic MM managed at two referral cancer centres in England were identified. Those with bone metastases (BMs) were selected. Patient and disease characteristics including skeletal related events (SREs) were extracted from medical records...
September 2017: Journal of Bone Oncology
https://www.readbyqxmd.com/read/28846937/a-novel-imp1-inhibitor-btynb-targets-c-myc-and-inhibits-melanoma-and-ovarian-cancer-cell-proliferation
#14
Lily Mahapatra, Neal Andruska, Chengjian Mao, Jeremy Le, David J Shapiro
The oncofetal mRNA-binding protein, IMP1 or insulin-like growth factor-2 mRNA-binding protein 2 (IGF2BP1), binds to and stabilizes c-Myc, β-TrCP1, and other oncogenic mRNAs, leading to increased expression of the proteins encoded by its target mRNAs. IMP1 is frequently overexpressed in cancer and is strongly correlated with a poor prognosis and reduced survival in melanoma, ovarian, breast, colon, and lung cancer. While IMP1 is an attractive anticancer drug target, there are no small molecule inhibitors of IMP1...
August 25, 2017: Translational Oncology
https://www.readbyqxmd.com/read/28840394/lipophilic-gold-i-complexes-with-1-3-4-oxadiazol-2-thione-or-1-3-thiazolidine-2-thione-moieties-synthesis-and-their-cytotoxic-and-antimicrobial-activities
#15
Angelina Maria de Almeida, Bruno Assis de Oliveira, Pedro Pôssa de Castro, Camille Carvalho de Mendonça, Ricardo Andrade Furtado, Heloiza Nicolella Diniz, Vânia Lúcia da Silva, Cláudio Galuppo Diniz, Denise Crispim Tavares, Heveline Silva, Mauro Vieira de Almeida
Novel lipophilic gold(I) complexes containing 1,3,4-oxadiazol-2-thione or 1,3-thiazolidine-2-thione derivatives were synthesized and characterized by IR, high resolution mass spectrometry, and (1)H, (13)C (31)P NMR. The cytotoxicity of the compounds was evaluated considering cisplatin and/or auranofin as reference in different tumor cell lines: colon cancer (CT26WT), metastatic skin melanoma (B16F10), breast adenocarcinoma (MCF-7), cervical carcinoma (HeLa), glioblastoma (M059 J). Normal human lung fibroblasts (GM07492-A) and kidney normal cell (BHK-21) were also evaluated...
August 24, 2017: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/28836277/the-risk-of-preterm-birth-and-growth-restriction-in-pregnancy-after-cancer
#16
Kathleen P Hartnett, Kevin C Ward, Michael R Kramer, Timothy L Lash, Ann C Mertens, Jessica B Spencer, Amy Fothergill, Penelope P Howards
It is unclear whether cancer and its treatments increase the risk of adverse pregnancy outcomes. Our aim was to examine whether cancer survivors have higher risks of poor outcomes in pregnancies conceived after diagnosis than women without cancer, and whether these risks differ by cancer type and race. Diagnoses from cancer registries were linked to pregnancy outcomes from birth certificates in three U.S. states. Analyses were limited to the first, live singleton birth conceived after diagnosis. Births to women without a previous cancer diagnosis in the registry were matched to cancer survivors on age at delivery, parity, race/ethnicity and education...
August 24, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28832808/prolonged-survival-after-surgical-resection-of-cerebral-metastasis-from-melanoma-with-multisystemic-metastasis-already-present-a-case-report-and-literature-review
#17
Samer Saad Hoz, Ahmed Aman Alkhaleeli, Awfa Aktham
CONTEXT: Malignant melanoma is the third most common cause of cerebral metastases after breast and lung cancer. Despite advances in therapeutic options, the prognosis for patients with cerebral metastases from melanoma remains poor, with a median survival time of six months after diagnosis. CASE REPORT: A 65-year-old woman was diagnosed with a malignant melanoma on the third toe of her left foot.The tumorous spot was excised surgically. However, the melanoma reappeared after one year and skin biopsy confirmed recurrence of malignant melanoma...
August 21, 2017: São Paulo Medical Journal, Revista Paulista de Medicina
https://www.readbyqxmd.com/read/28832172/-metastatic-pituitary-disorders
#18
V Novák, L Hrabálek, M Hampl, J Hoza, Z Fryšák, M Vaverka
BACKGROUND: Pituitary metastases are a rare complication of generalized cancer. Metastases to the pituitary gland occur in only 1% of patients operated on for sellar tumor. The most common presenting symptom in patients with pituitary metastases is diabetes insipidus, whereas this is rare in those with pituitary adenoma. MATERIAL AND METHODS: This publication presents the cases of two patients with pituitary metastases and a systematic review of the literature. English-language publications related to pituitary metastases and published from 1957 to 2016 were identified using the PubMed database...
2017: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/28827399/identification-of-nidogen-1-as-a-lung-metastasis-protein-through-secretome-analysis
#19
Maša Alečković, Yong Wei, Gary LeRoy, Simone Sidoli, Daniel D Liu, Benjamin A Garcia, Yibin Kang
Secreted proteins play crucial roles in mediating tumor-stroma interactions during metastasis of cancer to different target organs. To comprehensively profile secreted proteins involved in lung metastasis, we applied quantitative mass spectrometry-based proteomics and identified 392 breast cancer-derived and 302 melanoma-derived proteins secreted from highly lung metastatic cells. The cancer-specific lung metastasis secretome signatures (LMSSs) displayed significant prognostic value in multiple cancer clinical data sets...
August 21, 2017: Genes & Development
https://www.readbyqxmd.com/read/28820514/topical-opioids-and-antimicrobials-for-the-management-of-pain-infection-and-infection-related-odors-in-malignant-wounds-a-systematic-review
#20
Kathleen Finlayson, Laisa Teleni, Alexandra L McCarthy
PROBLEM IDENTIFICATION: Patients with malignant wounds report pain, distress from odor and exudate, decreased self-esteem, and poor quality of life. This systematic review explores topical opioids, antimicrobials, and odor-reducing agents for preventing or managing malignant wound pain, infection, and odor.
. LITERATURE SEARCH: MEDLINE®, EMBASE, the Cochrane Library, CINAHL®, and reference lists were searched to identify relevant studies.
. DATA EVALUATION: Eligible study designs included interventions with pre- and postintervention data...
September 1, 2017: Oncology Nursing Forum
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