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Breast cancer microRNA

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https://www.readbyqxmd.com/read/28935812/mir-130a-deregulates-pten-and-stimulates-tumor-growth
#1
Huijun Wei, Ri Cui, Julian Bahr, Nicola Zanesi, Zhenghua Luo, Wei Meng, Guang Liang, Carlo M Croce
H-RasV12 oncogene has been shown to promote autophagic cell death. Here we provide evidence of a contextual role for H-RasV12 in cell death that is varied by its effects on miR-130a. In E1A-immortalized murine embryo fibroblasts, acute expression of H-RasV12 promoted apoptosis but not autophagic cell death. miRNA screens in this system showed that miR-130a was strongly downregulated by H-RasV12 in this model system. Enforced expression of miR-130a increased cell proliferation in part via repression of PTEN...
September 21, 2017: Cancer Research
https://www.readbyqxmd.com/read/28935174/timp-3-mrna-expression-levels-positively-correlates-with-levels-of-mir-21-in-in-situ-bc-and-negatively-in-pr-positive-invasive-bc
#2
Nina Petrovic, Ahmad Sami, Jelena Martinovic, Marina Zaric, Irina Nakashidze, Silvana Lukic, Snezana Jovanovic-Cupic
BACKGROUND: Breast carcinomas (BC) belong to a heterogeneous group of malignant diseases. Correct categorization of BC based on molecular biomarkers has a very important role in deciding the proper course of therapy for each patient. It has been already shown that the decrease of TIMP metalloproteinase inhibitor 3 (TIMP-3) together with overexpression of microRNA-21 (miR-21) might be involved in the process of BC invasion. This is the first study that examined relationship among miR-21, TIMP-3 mRNA and TIPM-3 protein levels in BC groups formed according to invasiveness...
September 6, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28933253/the-role-of-p53-microrna-200-moesin-axis-in-invasion-and-drug-resistance-of-breast-cancer-cells
#3
Farheen Alam, Fatima Mezhal, Hussain El Hasasna, Vidhya A Nair, S R Aravind, Maha Saber Ayad, Ahmed El-Serafi, Wael M Abdel-Rahman
This study aimed to analyze the expression of microRNAs in relation to p53 status in breast cancer cells and to delineate the role of Moesin in this axis. We used three isogenic breast carcinoma cell lines MCF7 (with wild-type p53), 1001 (MCF7 with mutated p53), and MCF7-E6 (MCF7 in which p53 function was disrupted). MicroRNA expression was analyzed using microarray analysis and confirmed by real-time polymerase chain reaction. The 1001 clone with mutant p53 showed 22 upregulated and 25 downregulated microRNAs...
September 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28927100/hsa-mir-599-suppresses-the-migration-and-invasion-by-targeting-brd4-in-breast-cancer
#4
Yonghui Wang, Yana Sui, Qinwei Zhu, Xiaomei Sui
Breast cancer is the second leading cause of cancer-associated mortality in females in the USA. Hsa-miR-599 was demonstrated to function as a tumour suppressor during cancer progression. However, the function and mechanism of the hsa-miR-599 in human breast cancer remain elusive. Thus, the aim of the present study was to investigate the potential role of hsa-miR-599 in breast cancer biology. The expression levels of hsa-miR-599 in 40 pairs of surgical specimens and human breast cancer cell lines were detected using quantitative polymerase chain reaction analysis...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28925482/microrna-509-5p-functions-as-an-anti-oncogene-in-breast-cancer-via-targeting-sod2
#5
Y-H Song, J Wang, G Nie, Y-J Chen, X Li, X Jiang, W-H Cao
OBJECTIVE: Breast cancer is one of the most common malignant tumors in women worldwide. Considering the poor therapeutic effect of breast cancer, we are supposed to dissect the functioning mode of miR-509-5p on breast cancer cell growth and metastasis, providing therapeutic targets for breast cancer. PATIENTS AND METHODS: Quantitative Real-time PCR (qRT-PCR) assay was employed to detect miR-509-5p expression level. CCK8 assay and colony formation assay were incorporated to assess cell viability and proliferation capacities...
August 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28920955/mir-25-93-mediates-hypoxia-induced-immunosuppression-by-repressing-cgas
#6
Min-Zu Wu, Wei-Chung Cheng, Su-Feng Chen, Shin Nieh, Carolyn O'Connor, Chia-Lin Liu, Wen-Wei Tsai, Cheng-Jang Wu, Lorena Martin, Yaoh-Shiang Lin, Kou-Juey Wu, Li-Fan Lu, Juan Carlos Izpisua Belmonte
The mechanisms by which hypoxic tumours evade immunological pressure and anti-tumour immunity remain elusive. Here, we report that two hypoxia-responsive microRNAs, miR-25 and miR-93, are important for establishing an immunosuppressive tumour microenvironment by downregulating expression of the DNA sensor cGAS. Mechanistically, miR-25/93 targets NCOA3, an epigenetic factor that maintains basal levels of cGAS expression, leading to repression of cGAS during hypoxia. This allows hypoxic tumour cells to escape immunological responses induced by damage-associated molecular pattern molecules, specifically the release of mitochondrial DNA...
September 18, 2017: Nature Cell Biology
https://www.readbyqxmd.com/read/28915598/urine-mir-21-5p-as-a-potential-non-invasive-biomarker-for-gastric-cancer
#7
Hsiao-Wei Kao, Chao-Yu Pan, Chun-Hung Lai, Chew-Wun Wu, Wen-Liang Fang, Kuo-Hung Huang, Wen-Chang Lin
Many reports have implicated that microRNAs involve in cancer development and progression, such as miR-155 in breast cancers and miR-196 in gastric cancers. Furthermore, microRNAs are more stable than typical protein-coding gene mRNAs in varieties of clinical samples including body fluids. This suggests that they are potentially valuable biomarkers for cancer monitoring. In this study, we have used urine samples of gastric cancer patients to demonstrate the feasibility of urine microRNAs for gastric cancer detection...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28912888/sulforaphane-induced-cell-cycle-arrest-and-senescence-are-accompanied-by-dna-hypomethylation-and-changes-in-microrna-profile-in-breast-cancer-cells
#8
Anna Lewinska, Jagoda Adamczyk-Grochala, Anna Deregowska, Maciej Wnuk
Cancer cells are characterized by genetic and epigenetic alterations and phytochemicals, epigenetic modulators, are considered as promising candidates for epigenetic therapy of cancer. In the present study, we have investigated cancer cell fates upon stimulation of breast cancer cells (MCF-7, MDA-MB-231, SK-BR-3) with low doses of sulforaphane (SFN), an isothiocyanate. SFN (5-10 µM) promoted cell cycle arrest, elevation in the levels of p21 and p27 and cellular senescence, whereas at the concentration of 20 µM, apoptosis was induced...
2017: Theranostics
https://www.readbyqxmd.com/read/28895916/micrornas-in-different-histologies-of-soft-tissue-sarcoma-a-comprehensive-review
#9
REVIEW
Maria Anna Smolle, Andreas Leithner, Florian Posch, Joanna Szkandera, Bernadette Liegl-Atzwanger, Martin Pichler
Soft tissue sarcomas (STS) constitute a rare tumour entity comprising over 50 histological subtypes. MicroRNAs (miRNAs) are short non-protein coding RNA molecules that regulate gene expression by targeting the 3'-untranslated region of messenger RNAs. They are involved in a variety of human diseases, including malignancies, such as endometrial cancer, osteosarcoma, bronchial carcinoma and breast cancer. In STS, various miRNAs are differentially expressed, thus contributing to development, progression and invasion...
September 12, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28894844/microrna-let-7g-directly-targets-forkhead-box-c2-foxc2-to-modulate-bone-metastasis-in-breast-cancer
#10
Lei Wang, Ming Li, Yongxin Zhou, Yu Zhao
Aberrantly expressed microRNAs have been implicated in lots of cancers. Reduced amounts of let-7g have been found in breast cancer tissues. The function of let-7g in bone metastasis of breast cancer remains poorly understood. This study is to explore the significance of let-7g and its novel target gene in bone metastasis of breast cancer. The expression of let-7g or forkhead box C2 (FOXC2) was measured in human clinical breast cancer tissues with bone metastasis by using quantitative real-time Polymerase Chain Reaction (qRT-PCR)...
2017: Open Medicine (Warsaw, Poland)
https://www.readbyqxmd.com/read/28893247/cell-specific-mechanisms-of-tmem16a-ca-2-activated-chloride-channel-in-cancer
#11
REVIEW
Hui Wang, Liang Zou, Ke Ma, Jiankun Yu, Huizhe Wu, Minjie Wei, Qinghuan Xiao
TMEM16A (known as anoctamin 1) Ca(2+)-activated chloride channel is overexpressed in many tumors. TMEM16A overexpression can be caused by gene amplification in many tumors harboring 11q13 amplification. TMEM16A expression is also controlled in many cancer cells via transcriptional regulation, epigenetic regulation and microRNAs. In addition, TMEM16A activates different signaling pathways in different cancers, e.g. the EGFR and CAMKII signaling in breast cancer, the p38 and ERK1/2 signaling in hepatoma, the Ras-Raf-MEK-ERK1/2 signaling in head and neck squamous cell carcinoma and bladder cancer, and the NFκB signaling in glioma...
September 11, 2017: Molecular Cancer
https://www.readbyqxmd.com/read/28886271/microrna-signature-in-the-chemoprevention-of-functionally-enriched-stem-and-progenitor-pools-fespp-by-active-hexose-correlated-compound-ahcc
#12
Émilie A Graham, Jean-François Mallet, Majed Jambi, Hiroshi Nishioka, Kohei Homma, Chantal Matar
PURPOSE: Many breast cancer patients use natural compounds in their battle against breast cancer. Active Hexose Correlated Compound (AHCC®) is a cultured mushroom mycelium extract shown to favorably modulate the immune system and alleviate cancer burden. Cancer Stem cells (CSCs) are a subset of highly tumorigenic cancer cells that are thought to be responsible for recurrence. CSCs can be epigenetically regulated by microRNAs (miRNAs). We hypothesized that AHCC may influence CSCs by modulating tumor-suppressor or oncogenic miRNAs...
September 8, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/28886127/genome-wide-mirna-response-to-anacardic-acid-in-breast-cancer-cells
#13
David J Schultz, Penn Muluhngwi, Negin Alizadeh-Rad, Madelyn A Green, Eric C Rouchka, Sabine J Waigel, Carolyn M Klinge
MicroRNAs are biomarkers and potential therapeutic targets for breast cancer. Anacardic acid (AnAc) is a dietary phenolic lipid that inhibits both MCF-7 estrogen receptor α (ERα) positive and MDA-MB-231 triple negative breast cancer (TNBC) cell proliferation with IC50s of 13.5 and 35 μM, respectively. To identify potential mediators of AnAc action in breast cancer, we profiled the genome-wide microRNA transcriptome (microRNAome) in these two cell lines altered by the AnAc 24:1n5 congener. Whole genome expression profiling (RNA-seq) and subsequent network analysis in MetaCore Gene Ontology (GO) algorithm was used to characterize the biological pathways altered by AnAc...
2017: PloS One
https://www.readbyqxmd.com/read/28886115/androgen-receptor-mediated-downregulation-of-microrna-221-and-222-in-castration-resistant-prostate-cancer
#14
Bin Gui, Chen-Lin Hsieh, Philip W Kantoff, Adam S Kibel, Li Jia
MicroRNAs (miRNAs) play important roles in cancer formation and progression by suppressing the production of key functional proteins at the post-transcriptional level in a sequence-specific manner. While differential expression of miRNAs is widely observed in cancers including prostate cancer (PCa), how these miRNAs are transcriptionally regulated is largely unknown. MiRNA-221 and miRNA-222 (miR-221/-222) are well-established oncogenes and overexpressed in breast, liver, pancreas, and lung cancer, but their expression and biological functions in PCa remain controversial...
2017: PloS One
https://www.readbyqxmd.com/read/28884569/endogenous-microrna-triggered-and-real-time-monitored-drug-release-via-cascaded-energy-transfer-payloads
#15
Fan Yang, Tingting Zhang, Shan-Shan Li, Pei Song, Kai Zhang, Qi-Yuan Guan, Bin Kang, Jing-Juan Xu, Hong-Yuan Chen
It is a great challenge to design a drug delivery system with controlled manner, especially, triggered by an exclusive endogenous disease marker and with an easily-tracked release process. Herein, we developed a drug delivery platform of carbon dots which connected to stem-loop molecular beacon loaded with doxorubicin and polyethylene glycol modified folic acid. Such platform enables to release drugs on demand under the stimuli of endogenous microRNA-21, and turn on the fluorescence of carbon dots and doxorubicin, which allows to monitor the drug release process...
September 8, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28882698/prognostic-value-of-microrna-9-and-microrna-155-expression-in-triple-negative-breast-cancer
#16
Min Hye Jang, Hyun Jeong Kim, Jae Moon Gwak, Yul Ri Chung, So Yeon Park
MicroRNAs (miRNAs) are involved in regulation of epithelial-mesenchymal transition (EMT) during breast cancer progression. The purpose of this study was to analyze the clinicopathologic significance of expression of EMT-related miRNAs, miR-9 and miR-155, in triple-negative breast cancers (TNBCs). We analyzed relative expression levels of miR-9 and miR-155 in 190 surgically resected TNBC specimens using quantitative real-time polymerase chain reaction. Then we analyzed the relationship between these miRNA expression levels and EMT marker expression (vimentin, smooth muscle actin (SMA), osteonectin, N-cadherin, E-cadherin, CD146, and ZEB1) assessed by immunohistochemistry...
September 4, 2017: Human Pathology
https://www.readbyqxmd.com/read/28881990/a-new-method-to-study-the-change-of-mirna-mrna-interactions-due-to-environmental-exposures
#17
Francesca Petralia, Vasily N Aushev, Kalpana Gopalakrishnan, Maya Kappil, Nyan W Khin, Jia Chen, Susan L Teitelbaum, Pei Wang
Motivation: Integrative approaches characterizing the interactions among different types of biological molecules have been demonstrated to be useful for revealing informative biological mechanisms. One such example is the interaction between microRNA (miRNA) and messenger RNA (mRNA), whose deregulation may be sensitive to environmental insult leading to altered phenotypes. The goal of this work is to develop an effective data integration method to characterize deregulation between miRNA and mRNA due to environmental toxicant exposures...
July 15, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28881597/tgfbeta-and-mirna-regulation-in-familial-and-sporadic-breast-cancer
#18
Katia Danza, Simona De Summa, Rosamaria Pinto, Brunella Pilato, Orazio Palumbo, Massimo Carella, Ondina Popescu, Maria Digennaro, Rosanna Lacalamita, Stefania Tommasi
The term 'BRCAness' was introduced to identify sporadic malignant tumors sharing characteristics similar to those germline BRCA-related. Among all mechanisms attributable to BRCA1 expression silencing, a major role has been assigned to microRNAs. MicroRNAs role in familial and sporadic breast cancer has been explored but few data are available about microRNAs involvement in homologous recombination repair control in these breast cancer subgroups. Our aim was to seek microRNAs associated to pathways underlying DNA repair dysfunction in breast cancer according to a family history of the disease...
August 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28880270/circulating-micrornas-in-breast-cancer-novel-diagnostic-and-prognostic-biomarkers
#19
REVIEW
Rimi Hamam, Dana Hamam, Khalid A Alsaleh, Moustapha Kassem, Waleed Zaher, Musaad Alfayez, Abdullah Aldahmash, Nehad M Alajez
Effective management of breast cancer depends on early diagnosis and proper monitoring of patients' response to therapy. However, these goals are difficult to achieve because of the lack of sensitive and specific biomarkers for early detection and for disease monitoring. Accumulating evidence in the past several years has highlighted the potential use of peripheral blood circulating nucleic acids such as DNA, mRNA and micro (mi)RNA in breast cancer diagnosis, prognosis and for monitoring response to anticancer therapy...
September 7, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28876975/mir-129-2-mediates-down-regulation-of-progesterone-receptor-in-response-to-progesterone-in-breast-cancer-cells
#20
Mukul Godbole, Pratik Chandrani, Nilesh Gardi, Hemant Dhamne, Kuldeep Patel, Neelima Yadav, Sudeep Gupta, Rajendra Badwe, Amit Dutt
OBJECTIVE: Hormonal therapy is an important component of first line of treatment for breast cancer. Response to hormonal therapy is influenced by the progesterone receptor (PR)-status of breast cancer patients. However as an early effect, exposure to progesterone decreases expression of PR in breast cancer cells. An understanding of the mechanism underlying down-regulation of PR could help improve response to hormonal therapy. METHODS: We performed small RNA sequencing of breast cancer cells for identification of microRNAs targeting PR in response to progesterone treatment...
September 6, 2017: Cancer Biology & Therapy
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