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Borderline tumors

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https://www.readbyqxmd.com/read/28528215/patients-criteria-determining-difficulty-of-the-laparoscopic-lateral-transperitoneal-adrenalectomy-a-retrospective-cohort-study
#1
Michał Natkaniec, Jadwiga Dworak, Michał Pędziwiatr, Magdalena Pisarska, Piotr Major, Marcin Dembiński, Marek Winiarski, Andrzej Budzyński
BACKGROUND: Identification of patients in whom adrenalectomy may be more difficult, can help in decision making in borderline and doubtful cases. The aim of the study was to determine patients criteria influencing difficulty of laparoscopic lateral transperitoneal adrenalectomy (LTA). MATERIAL AND METHODS: The study enrolled 275 patients who underwent LTA. We analyzed the impact of gender, age, history of previous abdominal surgery, body mass index, risk of anesthesia measured as ASA scale, size, localization (left/right), and histological type of the tumor on parameters reflecting the level of difficulty of the procedure: operative time, intraoperative blood loss, conversion rate and intraoperative complications rate...
May 17, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28523415/pictorial-review-of-vascular-involvement-and-complex-vascular-reconstructions-in-borderline-to-minimally-advanced-pancreatic-malignancies
#2
REVIEW
Donald L Ly, Seng Thipphavong, Boraiah Sreeharsha
PURPOSE: To review borderline resectability criteria for pancreatic malignancies, show examples of few surgically treated minimally advanced pancreatic malignancies, discuss various complex vascular reconstructions, and highlight the imaging appearances. BACKGROUND: Often aggressive surgical approaches are used to treat borderline to minimally advanced pancreatic malignancies in specialist centers. As abdominal radiologists it is essential to have up-to-date knowledge to distinguish such tumors with accuracy and also be well versed with the various vascular reconstructions used in such surgeries...
May 18, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28523039/borderline-tumors-of-the-ovary-a-clinicopathological-study
#3
Samia Yasmeen, Abdul Hannan, Fareeha Sheikh, Amir Ali Syed, Neelam Siddiqui
OBJECTIVE: To report experience with borderline ovarian tumors (BOTs) in a developing country like Pakistan with limited resources and weak database of health system. METHODS: Patients with BOTs managed at Shaukat Khanum Cancer hospital, Lahore, Pakistan from 2004 to 2014 were included and reviewed retrospectively. Data was recorded on histopathological types, age, CA-125, stage of disease, treatment modalities and outcomes. RESULTS: Eighty-six patients with BOT were included with a median age of 35 years...
March 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28507642/diagnostic-imaging-of-pregnant-women-the-role-of-magnetic-resonance-imaging
#4
Monika Bekiesińska-Figatowska, Anna Romaniuk-Doroszewska, Sylwia Szkudlińska-Pawlak, Agnieszka Duczkowska, Jarosław Mądzik, Martyna Szopa-Krupińska, Tomasz M Maciejewski
BACKGROUND: Presentation of magnetic resonance imaging (MRI) findings in pregnant women in the Department of Diagnostic Imaging, Institute of Mother and Child, Warsaw, Poland. MATERIAL/METHODS: Forty-three symptomatic pregnant women underwent MRI between 9 and 33 weeks of gestation (mean of 23 weeks). Moreover, we included 2 pregnant women who underwent fetal MRI and had incidental abnormalities. RESULTS: In 9 cases, we excluded the suspected brain abnormalities...
2017: Polish Journal of Radiology
https://www.readbyqxmd.com/read/28505557/follow-up-of-patients-with-localized-breast-cancer-and-first-indicators-of-advanced-breast-cancer-recurrence-a-retrospective-study
#5
Julien Viot, Martin Bachour, Aurélia Meurisse, Xavier Pivot, Frédéric Fiteni
We conducted a retrospective study to assess the follow-up of patients with localized breast cancer and the first indicators of advanced breast cancer recurrence. All patients with advanced breast cancer recurrence treated between January 2010 and June 2016 in our institution were registered. Among these patients, 303 patients initially treated for early breast cancer with curative intent were identified. After initial curative treatment, follow-up involved the oncologist, the general practitioner and the gynecologist in 68...
May 12, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28503633/reactive-oxygen-species-and-serous-epithelial-ovarian-adenocarcinoma
#6
Shakeria Cohen, Sharifeh Mehrabi, Xuebiao Yao, Stephanie Millingen, Felix O Aikhionbare
Serous ovarian cancer (SOC) is usually diagnosed at late stage and stage-adjusted five year survival rate is low. Mortality is relatively heavy on African-Americans/Black (AA) affected with SOC compared to their Caucasian counterparts, though the cause for the disparity remains unclear. DNA damage induced by oxidative stress has been linked to ovarian cancer, but the role of oxidative stress in distinguishing differences in aggressive SOC tumors among patients is yet to be determined. This study aims to determine the levels of reactive oxygen species (ROS), malondialdehyde (MDA), reactive carbonyl groups and antioxidants in primary SOC normal, precancerous (cystadenoma, borderline) and invasive (III/IV) tissue samples obtained from AA and Caucasian subgroups...
November 2016: Cancer Res J (N Y N Y)
https://www.readbyqxmd.com/read/28500412/-hereditary-breast-and-ovarian-cancer
#7
REVIEW
S F Lax
Hereditary breast and ovarian carcinomas are frequently caused by germline mutations of the BRCA1 and BRCA2 genes (BRCA1/2 syndromes) and are often less associated with other hereditary syndromes such as Li-Fraumeni and Peutz-Jeghers. The BRCA1/2 proteins have a special role in DNA repair. Therefore, loss of function due to mutation causes an accumulation of mutations in other genes and subsequent tumorigenesis at an early age. BRCA1/2 mutations are irregularly distributed over the length of the genes without hot spots, although special mutations are known...
May 12, 2017: Der Pathologe
https://www.readbyqxmd.com/read/28498249/clinicopathological-characteristics-and-prognostic-factors-of-synchronous-endometrial-and-ovarian-cancers-a-single-institute-review-of-43-cases
#8
Vandana Jain, Rupinder Sekhon, Sunil Pasricha, Shveta Giri, Kanika Batra Modi, Eliza Shrestha, Dharma Ram, Sudhir Rawal
OBJECTIVES: The objectives of our study were to demonstrate the clinicopathological characteristics and determine the prognostic factors for women with synchronous primary cancers of the endometrium and ovary. METHODS: A retrospective analysis of 43 pathologically proven cases of synchronous primary endometrial and ovarian cancers diagnosed between January 2005 and December 2015 was carried out. Patients with uterine sarcomas, carcinosarcomas, borderline tumors, and nonepithelial tumors of the ovary and patients who received neoadjuvant chemotherapy were excluded from the study...
June 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28497509/characteristics-and-prognosis-of-glomangiopericytomas-a-systematic-review
#9
REVIEW
Eun Su Park, Jiyoung Kim, Sun-Young Jun
BACKGROUND: Glomangiopericytoma belongs to the category of borderline/low-malignant-potential tumors of the sinonasal tract, but no studies about prognosis have been reported. METHODS: To define the characteristics of glomangiopericytoma and to identify its prognostic factors, a systematic review was performed. A total of 337 cases of glomangiopericytomas were analyzed. RESULTS: Patients with glomangiopericytoma demonstrating resection margin involvement and receiving radiotherapy/chemotherapy had a significantly worse disease-free survival time (P =  ...
May 12, 2017: Head & Neck
https://www.readbyqxmd.com/read/28493803/soft-tissue-sarcomas-of-the-abdomen-and-pelvis-radiologic-pathologic-features-part-2-uncommon-sarcomas
#10
Angela D Levy, Maria A Manning, Markku M Miettinen
Soft-tissue sarcomas occurring in the abdomen and pelvis are an uncommon but important group of malignancies. Recent changes to the World Health Organization classification of soft-tissue tumors include the movement of gastrointestinal stromal tumors (GISTs) into the soft-tissue tumor classification. GIST is the most common intraperitoneal sarcoma. Liposarcoma is the most common retroperitoneal sarcoma, and leiomyosarcoma is the second most common. GIST, liposarcoma, and leiomyosarcoma account for the majority of sarcomas encountered in the abdomen and pelvis and are discussed in part 1 of this article...
May 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28493257/expression-of-p53-and-selected-proliferative-markers-ki-67-mcm3-pcna-and-topoisomerase-ii%C3%AE-in-borderline-ovarian-tumors-correlation-with-clinicopathological-features
#11
Klaudiusz Ciepliński, Maciej Jóźwik, Anna Semczuk-Sikora, Marek Gogacz, Dorota Lewkowicz, Atanas Ignatov, Andrzej Semczuk
BACKGROUND: The expression of p53 has been studied not only in primary human ovarian carcinomas, but also in borderline ovarian tumors, however, the results were discordant. Expression patterns of proteins involved in cell proliferation and apoptosis have been investigated in various human neoplasms, including female genital tract neoplasms. OBJECTIVE: The aim of this investigation was to assess the staining pattern and immunolocalization of p53 and selected proliferative markers (Ki-67, MCM3, PCNA, and topoisomerase IIα) in borderline ovarian tumors (BOTs)...
May 11, 2017: Histology and Histopathology
https://www.readbyqxmd.com/read/28488545/determination-of-braf-v600e-ve1-protein-expression-and-braf-gene-mutation-status-in-codon-600-in-borderline-and-low-grade-ovarian-cancers
#12
Pawel Sadlecki, Pawel Walentowicz, Magdalena Bodnar, Andrzej Marszalek, Marek Grabiec, Malgorzata Walentowicz-Sadlecka
Epithelial ovarian tumors are a group of morphologically and genetically heterogeneous neoplasms. Based on differences in clinical phenotype and genetic background, ovarian neoplasms are classified as low-grade and high-grade tumor. Borderline ovarian tumors represent approximately 10%-20% of all epithelial ovarian masses. Various histological subtypes of ovarian malignancies differ in terms of their risk factor profiles, precursor lesions, clinical course, patterns of spread, molecular genetics, response to conventional chemotherapy, and prognosis...
May 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28487789/abdominopelvic-tuberculosis-with-a-frozen-section-analysis-consistent-with-ovarian-cancer
#13
Agrimaldo Martins-Filho, Paula Carolina Arvelos Crispim, Renata Margarida Etchebehere, Cristina da Cunha Hueb Barata de Oliveira, Eddie Fernando Candido Murta, Rosekeila Simões Nomelini
Pelvic tuberculosis is a type of extrapulmonary tuberculosis. The disease is accompanied by clinical and laboratory findings which may be unspecific and present aspects of other diseases, including gynecological malignancies. In this report, the authors presented a case of pelvic tuberculosis associated with peritoneal tuberculosis in a young woman exhibiting imaging and tumor markers consistent with ovarian neoplasm. An intraoperative frozen section analysis detected atypical cells that were suggestive of ovarian borderline or malignant epithelial neoplasia...
2017: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/28482348/prolonged-neoadjuvant-therapy-for-locally-advanced-pancreatic-cancer
#14
Hidetoshi Eguchi, Daisaku Yamada, Yoshifumi Iwagami, Kunihito Gotoh, Koichi Kawamoto, Hiroshi Wada, Tadafumi Asaoka, Takehiro Noda, Yutaka Takeda, Masahiro Tanemura, Daisuke Sakai, Taroh Satoh, Toshihiro Kudo, Fumiaki Isohashi, Masaki Mori, Yuichiro Doki
PURPOSE: The purpose of this study was to investigate if prolonged neoadjuvant therapy, for locally advanced pancreatic cancer could be used to identify those patients who could benefit from resection surgery. METHODS: Thirty-four patients with locally advanced pancreatic cancer invading the adjacent major arteries underwent chemoradiotherapy, followed by 6 months of systemic chemotherapy, unless their tumor was already resectable. After this combination treatment, surgical resection was performed on those patients with tumors judged to be at least borderline resectable...
May 9, 2017: Digestive Surgery
https://www.readbyqxmd.com/read/28480714/nanoparticle-protein-interactions-therapeutic-approaches-and-supramolecular-chemistry
#15
Mathis Kopp, Sebastian Kollenda, Matthias Epple
Research on nanoparticles has evolved into a major topic in chemistry. Concerning biomedical research, nanoparticles have decisively entered the field, creating the area of nanomedicine where nanoparticles are used for drug delivery, imaging, and tumor targeting. Besides these functions, scientists have addressed the specific ways in which nanoparticles interact with biomolecules, with proteins being the most prominent example. Depending on their size, shape, charge, and surface functionality, specifically designed nanoparticles can interact with proteins in a defined way...
May 8, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28479065/frequency-of-incidental-serous-tubal-intraepithelial-carcinoma-stic-in-women-without-a-history-of-or-genetic-risk-factor-for-high-grade-serous-carcinoma-a-six-year-study
#16
Emily E K Meserve, Jelena Mirkovic, James R Conner, Eric Yang, Michael G Muto, Neil Horowitz, Kyle C Strickland, Brooke E Howitt, Christopher P Crum
Objective The purpose of this study was to determine the prevalence of incidentally discovered serous tubal intraepithelial carcinoma in women without a genetic risk for or history of high grade serous carcinoma (HGSC) in the gynecologic tract. METHODS: All pathology reports at our institution that included bilateral salpingectomies from January 2006-December 2011 were examined in women >50years old in which the entire tube or the distal one-third was examined histologically with the complete (proximal and distal fallopian tube) or modified (distal one third of the tube) SEE-FIM protocol...
May 4, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28479047/the-analysis-of-expression-of-p16-protein-in-group-of-53-patients-treated-for-sinonasal-inverted-papilloma
#17
Roland Zydroń, Andrzej Marszałek, Magdalena Bodnar, Paweł Kosikowski, Grażyna Greczka, Małgorzata Wierzbicka
INTRODUCTION: Sinonasal Inverted Papilloma (IP) constitute relevant therapeutic problem due to destructive character of growth, tendency to recur and the possibility of malignant transformation. Therefore, many attempts to identify risk factors for IP occurrence have been undertaken, as well as research to find markers that would allow for the earlier detection of tumors and the application of adequate therapy. A widely known risk factor of IP is HPV infection. One of the markers of HPV infection and the ongoing effect of this change (although arousing some controversy) is the expression of the p16 protein...
April 19, 2017: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/28470574/tff3-expression-as-stratification-marker-in-borderline-epithelial-tumors-of-the-ovary
#18
Ahmed El-Balat, Iryna Schmeil, Thomas Karn, Sven Becker, Nicole Sänger, Uwe Holtrich, Ruza Arsenic
Borderline tumors (BOT) of the ovary account for 10% to 20% of ovarian neoplasms. Like ovarian cancer, BOT encompass several different histological subtypes (serous, mucinous, endometrioid, clear cell, transitional cell and mixed) with serous (SBOT) and mucinous (MBOT) the most common. Current hypotheses suggest low-grade serous carcinoma may develop in a stepwise fashion from SBOT whereas the majority of high grade serous carcinomas develop rapidly presumably from inclusion cysts or ovarian surface epithelium...
May 3, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28468714/the-indications-for-laparoscopic-pancreatectomy
#19
Marco Siech, Peter Strauss, Stephanie Huschitt, Detlef K Bartsch, Uwe Wittel, Tobias Keck
BACKGROUND: Laparoscopic pancreatectomy is not yet established as a routine procedure everywhere in Germany or in other countries. Few data are available on its short- and long-term outcomes. METHODS: From 2008 onward, a working group initiated by 10 centers and currently comprising 34 centers has gathered data on all cases of laparoscopic pancreatectomy. Procedures in which laparoscopy was converted to open surgery are also included. RESULTS: The registry now contains 550 data sets representing 267 cases of benign disease, 244 malignancies, and 39 borderline tumors...
April 14, 2017: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/28465851/borderline-clear-cell-adenofibroma-of-the-ovary
#20
Pilaiwan Kleebkaow, Apiwat Aue-Aungkul, Amornrat Temtanakitpaisan, Chumnan Kietpeerakool
Borderline clear cell tumors are extremely rare, and few cases have been reported in the literature. Herein, we present a case of borderline clear cell adenofibroma of the ovary in a 58-year-old woman who presented with a pelvic mass and constipation. Physical examination revealed a 10 cm solid midline pelvic mass. Computed tomography showed an 8 cm heterogeneous enhancing mass attached to the left posterolateral wall of the uterus. The patient's serum CA 125 levels were slightly elevated (80.9 U/ml)...
2017: Case Reports in Pathology
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