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https://www.readbyqxmd.com/read/28646282/surgery-for-pancreatic-ductal-adenocarcinoma
#1
REVIEW
R Vera, L Díez, E Martín Pérez, J C Plaza, A Sanjuanbenito, A Carrato
Surgical resection is the only potentially curative option in the treatment of pancreatic ductal adenocarcinoma. Preoperative radiological imaging allows to rule out the presence of metastases. Three resectability categories are established based on the radiological findings depending on the degree of contact between the tumor and the blood vessels. Histological confirmation of malignancy is only required in cases of borderline or non-resectable tumors, prior to neoadjuvant treatment initiation. Diagnostic laparoscopy is recommended in the presence of large tumors of the body or tail and in borderline tumors to explore the possibility of resection and to apply treatment with curative intent, as well as in those cases with high level of biomarkers to rule out peritoneal involvement...
June 23, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28639280/mutational-profiles-of-brenner-tumors-show-distinctive-features-uncoupling-urothelial-carcinomas-and-ovarian-carcinoma-with-transitional-cell-histology
#2
Nicole Pfarr, Silvia Darb-Esfahani, Jonas Leichsenring, Eliane Taube, Melanie Boxberg, Ioana Braicu, Moritz Jesinghaus, Roland Penzel, Volker Endris, Aurelia Noske, Wilko Weichert, Peter Schirmacher, Carsten Denkert, Albrecht Stenzinger
Brenner tumors (BT) are rare ovarian tumors encompassing benign, borderline and malignant variants. While the histopathology of BTs and their clinical course is well described, little is known about the underlying genetic defects. We employed targeted next generation sequencing to analyze the mutational landscape in a cohort of 23 BT cases (17 benign, 2 borderline, 4 malignant) and 3 ovarian carcinomas with transitional cell histology (TCC). Copy number variations (CNV) were validated by fluorescence in-situ hybridization (FISH) and quantitative PCR-based copy number assays...
June 22, 2017: Genes, Chromosomes & Cancer
https://www.readbyqxmd.com/read/28638216/role-of-surgery-in-pancreatic-cancer
#3
EDITORIAL
Trond A Buanes
Treatment of pancreatic cancer is multimodal and surgery is an essential part, mandatory for curative potential. Also chemotherapy is essential, and serious postoperative complications or rapid disease progression may preclude completion of multimodal treatment. The sequence of treatment interventions has therefore become an important concern, and numerous ongoing randomized controlled trials compare clinical outcome after upfront surgery and neoadjuvant treatment with subsequent resection. In previous years, borderline resectable and locally advanced pancreatic cancer was most often considered unresectable...
June 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28636628/effects-of-spirulina-on-the-functions-and-redox-status-of-auditory-system-in-senescence-accelerated-prone-8-mice
#4
Yin-Ching Chan, Juen-Haur Hwang
To our knowledge, the effects of Spirulina platensis water extract (SP) on hearing function have not yet been reported. This study investigated the effects of SP on the function and redox status of the auditory system. Auditory brainstem responses and redox status were compared between two groups of 3-month-old senescence-accelerated prone-8 (SAMP8) mice: the control group was fed a normal diet, and the experimental group was fed a normal diet with oral supplementation of SP for 6 weeks. Compared with the control group, the experimental group had significantly lower hearing thresholds according to auditory brainstem responses measured using click sounds and 8-kHz tone burst sound stimulation at the end of this study...
2017: PloS One
https://www.readbyqxmd.com/read/28629557/multiparametric-mri-for-differentiation-of-borderline-ovarian-tumors-from-stage-i-malignant-epithelial-ovarian-tumors-using-multivariate-logistic-regression-analysis
#5
Fatmaelzahraa Abdelfattah Denewar, Mitsuru Takeuchi, Misugi Urano, Yuki Kamishima, Tatsuya Kawai, Naoki Takahashi, Moe Takeuchi, Susumu Kobayashi, Junichi Honda, Yuta Shibamoto
OBJECTIVE: To assess the value of contrast-enhanced MRI, apparent diffusion coefficient (ADC) measurement, and CA-125 measurement for differentiating borderline ovarian tumors (BOTs) from stage I malignant epithelial ovarian tumors (MEOTs). MATERIAL AND METHODS: This retrospective study included 43 patients with BOTs and 43 patients with stage I MEOTs who underwent contrast-enhanced MRI with DWI and CA-125 analysis. Two radiologists evaluated the MRI findings in consensus...
June 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28627000/pencil-beam-scanned-protons-for-the-treatment-of-patients-with-ewing-sarcoma
#6
Damien C Weber, Fritz R Murray, Dora Correia, Alessandra Bolsi, Martina Frei-Welte, Alessia Pica, Antony J Lomax, Ralf Schneider, Barbara Bachtiary
BACKGROUND: Few data exist regarding the clinical outcome of patients with Ewing sarcoma (EWS) treated with pencil beam scanning proton therapy (PT). We report the outcome of children, adolescents and young adults (AYA) treated with PT at the Paul Scherrer Institute. MATERIALS: Thirty-eight patients (median age, 9.9 years) received a median dose of 54.9 Gy(RBE) (where RBE is relative biologic effectiveness). Size of the tumor ranged from 1.7 to 24 cm. Most common primary site was axial/pelvic (n = 27; 71%)...
June 19, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28626731/how-to-differentiate-borderline-hepatic-nodules-in-hepatocarcinogenesis-emphasis-on-imaging-diagnosis
#7
REVIEW
Hyun Jeong Park, Byung Ihn Choi, Eun Sun Lee, Sung Bin Park, Jong Beum Lee
BACKGROUND: Rapid advances in liver imaging have improved the evaluation of hepatocarcinogenesis and early diagnosis and treatment of hepatocellular carcinoma (HCC). In this situation, detection of early-stage HCC in its development is important for the improvement of patient survival and optimal treatment strategies. Because early HCCs are considered precursors of progressed HCC, precise differentiation between a dysplastic nodule (DN), especially a high-grade DN, and early HCC is important...
June 2017: Liver Cancer
https://www.readbyqxmd.com/read/28624977/interaction-of-mammographic-breast-density-with-menopausal-status-and-postmenopausal-hormone-use-in-relation-to-the-risk-of-aggressive-breast-cancer-subtypes
#8
Lusine Yaghjyan, Rulla M Tamimi, Kimberly A Bertrand, Christopher G Scott, Matthew R Jensen, V Shane Pankratz, Kathy Brandt, Daniel Visscher, Aaron Norman, Fergus Couch, John Shepherd, Bo Fan, Yunn-Yi Chen, Lin Ma, Andrew H Beck, Steven R Cummings, Karla Kerlikowske, Celine M Vachon
PURPOSE: We examined the associations of mammographic breast density with breast cancer risk by tumor aggressiveness and by menopausal status and current postmenopausal hormone therapy. METHODS: This study included 2596 invasive breast cancer cases and 4059 controls selected from participants of four nested case-control studies within four established cohorts: the Mayo Mammography Health Study, the Nurses' Health Study, Nurses' Health Study II, and San Francisco Mammography Registry...
June 17, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28623811/residential-exposure-to-pesticides-as-risk-factor-for-childhood-and-young-adult-brain-tumors-a-systematic-review-and-meta-analysis
#9
REVIEW
Geneviève Van Maele-Fabry, Laurence Gamet-Payrastre, Dominique Lison
BACKGROUND: Accumulating evidence suggests a positive association between exposure to non-agricultural pesticides and childhood brain tumors (CBT). OBJECTIVE: (1) To conduct a systematic review and meta-analysis of published studies on the association between residential/household/domestic exposure to pesticides and childhood brain tumors. (2) To clarify variables that could impact the results. METHODS: Publications in English were identified from a MEDLINE search through 28 February 2017 and from the reference list of identified publications...
June 14, 2017: Environment International
https://www.readbyqxmd.com/read/28614235/pulmonary-spindle-cell-carcinoma-with-unusual-morphology-a-rare-case-report-and-review-of-the-literature
#10
Dian-Jun Qi, Bing Liu, Liang Feng, Lin Zhao, Ping Yan, Jiang Du, Qing-Fu Zhang
RATIONALE: Pulmonary spindle cell carcinoma (PSCC) is a highly malignant carcinoma that often exhibits the histopathological characteristic of cell pleomorphism. PATIENT CONCERNS: Here, we report a PSCC case in a 59-year-old woman with multiple metastases. The pathological manifestation of this case did not show high-grade pleomorphism or atypia, and was easily mimicked by other borderline or low-grade malignant tumors such as an inflammatory myofibroblastic tumor (IMT)...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28612620/sampus-meltump-and-thimump-diagnostic-categories-characterized-by-uncertain-biological-behavior
#11
L Roncati, F Piscioli, T Pusiol
In the dermatopathological practice, there is a group of atypical melanocytic lesions with borderline histological features between benign simulants and malignant melanoma (MM), due to conflicting diagnostic criteria and inter-observer disagreement. In these cases, the dermatopathologist is authorized to seek consult with an established expert in the field, but even the most experienced specialist may not be sure about the correct diagnosis and the subsequent biological behavior. There is general consensus among qualified dermatopathologists that can be helpful to insert these ambiguous cases into two diagnostic categories: SAMPUS (Superficial Atypical Melanocytic Proliferations of Unknown Significance) and MELTUMP (MELanocytic Tumors of Uncertain Malignant Potential)...
2017: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/28612563/-expression-and-clinical-significance-of-numb-and-p53-proteins-in-epithelial-ovarian-carcinoma
#12
Min Xu, Hong-Ju He, Huan Zhang, Ao Wang, Jie Chen
OBJECTIVES: To investigate the expression and clinical significance of Numb and P53 proteins in epithelial ovarian carcinoma. METHODS: We co-tested the expressions of Numb and P53 proteins in epithelial ovarian tissues by immunohistochemistry, including 20 cases of normal tissues, 29 cases of benign tumors, 35 cases of borderline ovarian tumors and 87 cases of epithelial ovarian carcinoma. Their clinical significance was analyzed. RESULTS: The positive expression rates of Numb protein in normal ovarian tissues, benign ovarian tumors, borderline ovarian tumors and epithelial ovarian carcinoma were 5%, 13...
January 2017: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/28608409/neoadjuvant-chemoradiotherapy-of-pancreatic-cancer-induces-a-favorable-immunogenic-tumor-microenvironment-associated-with-increased-major-histocompatibility-complex-class-i-related-chain-a-b-expression
#13
Takashi Murakami, Yuki Homma, Ryusei Matsuyama, Ryutaro Mori, Kentaro Miyake, Yusaku Tanaka, Kanechika Den, Yoji Nagashima, Masatoshi Nakazawa, Yukihiko Hiroshima, Michio Ueda, Kuniya Tanaka, Robert M Hoffman, Michael Bouvet, Itaru Endo
BACKGROUND: Damage-associated molecular patterns (DAMPs) are related to immune responses in malignant tumors including tumor-infiltrating lymphocytes (TILs). The aim of the present study was to determine the relationship between expression of components of DAMPs and TILs in pancreatic cancer patients who underwent neoadjuvant chemoradiotherapy (NACRT) versus those who did not. METHODS: NACRT was administered to 51 patients with borderline-resectable pancreatic cancer and not to 33 patients with resectable pancreatic cancer...
June 12, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28608121/a-prospective-phase-ii-trial-of-neoadjuvant-s-1-with-concurrent-hypofractionated-radiotherapy-in-patients-with-resectable-and-borderline-resectable-pancreatic-ductal-adenocarcinoma
#14
Keiichi Okano, Hironobu Suto, Minoru Oshima, Eri Maeda, Naoki Yamamoto, Keitaro Kakinoki, Hideki Kamada, Tsutomu Masaki, Shigeo Takahashi, Toru Shibata, Yasuyuki Suzuki
BACKGROUND: The ideal neoadjuvant treatment protocol for patients with pancreatic cancer (PDAC) remains unclear. We evaluated the efficacy and safety of neoadjuvant hypofractionated chemoradiotherapy with S-1 for patients with resectable (R) and borderline resectable (BR) PDAC. METHODS: Eligibility criteria included patients with R and BR PDAC, performance status 0-1, and age 20-85 years. Hypofractionated external-beam radiotherapy (30 Gy in 10 fractions) with concurrent S-1 (60 mg/m(2)) was delivered 5 days/week for 2 weeks prior to pancreatectomy...
June 12, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28604453/management-of-primary-retroperitoneal-mucinous-tumors-a-retrospective-meta-analysis
#15
Benjamin Wolf, Christin Kunert, Lars-Christian Horn, Jens Einenkel
OBJECTIVE: Primary retroperitoneal mucinous tumors (PRMTs) are rare epithelial neoplasms arising in the retroperitoneal space whose pathogenesis is poorly understood. To date, only single-case reports and small case series on diagnosis and management of these tumors exist. The aim of this first-time meta-analysis was to provide more reliable data to inform the management of PRMTs. METHODS: Database searches were conducted to identify case reports and case series between the years of 1975 and 2015...
June 10, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28599482/an-unusual-case-of-pseudomyxoma-peritonei-associated-with-synchronous-primary-mucinous-tumors-of-the-ovary-and-appendix-a-case-report
#16
Dong Soo Suh, Yong Jung Song, Byung Su Kwon, Sul Lee, Nam Kyung Lee, Kyung Un Choi, Ki Hyung Kim
Pseudomyxoma peritonei (PMP) is a rare disease that usually originates from mucinous neoplasms of the appendix and, less commonly, from extra-appendiceal tumors, but it may also be caused by synchronous primary mucinous tumors of the ovary and appendix. The current study discusses the case of a 73-year-old female who presented with progressively worsening indigestion and abdominal distension. Magnetic resonance imaging of the pelvis revealed a large cystic mass with a thin enhancing septa arising from the right ovary and ascites with scalloping of the liver surface...
June 2017: Oncology Letters
https://www.readbyqxmd.com/read/28598117/-expression-level-of-membrane-associated-proteins-numb-in-epithelial-ovarian-carcinoma-and-its-relationship
#17
Hong Jing, Xiao-Yu Liu, Ya-Li Chen, Li-Ping Bai, Ai Zheng
OBJECTIVES: To explore the expression level of membrane-associated protein Numb in epithelial ovarian carcinoma and its relationship with ovarian cancer stem cell markers CD117,CD133,acetaldehyde dehydrogenase 1(ALDH1). METHODS: A total of 136 patients who had ovarian tumors and 22 patients who had not ovarian tumors in Department of Gynaecology and Obstetrics,West China Second University Hospital,Sichuan University were chosen as the study subjects.According to the histopathologic examination results,they were divided into epithelial ovarian carcinoma group (n=92),ovarian borderline tumor group (n=23),ovarian benign tumor group (n=21) and normal ovary group (n=22)...
November 2016: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/28594258/first-line-chemotherapy-with-pemetrexed-plus-cisplatin-for-malignant-peritoneal-mesothelioma
#18
Eriko Fujimoto, Takashi Kijima, Kozo Kuribayashi, Yoshiki Negi, Shingo Kanemura, Koji Mikami, Hiroshi Doi, Kazuhiro Kitajima, Takashi Nakano
BACKGROUND: Mesothelioma of peritoneal origin has wider variation in treatment outcomes than mesothelioma of pleural origin, likely because peritoneal mesothelioma comprises borderline malignant variants and aggressive malignant peritoneal mesothelioma (MPeM). This study retrospectively evaluates the efficacy of first-line systemic pemetrexed and cisplatin chemotherapy in MPeM. RESEARCH DESIGN AND METHODS: Twenty-four patients with histologically proven MPeM were treated with pemetrexed plus cisplatin as a first-line systemic chemotherapy...
June 15, 2017: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/28586014/lewis-y-antigen-promotes-the-progression-of-epithelial-ovarian-cancer-by-stimulating-muc1-expression
#19
Rui Hou, Luo Jiang, Dawo Liu, Bei Lin, Zhenhua Hu, Jian Gao, Danye Zhang, Shulan Zhang, Masao Iwamori
MUC1 is a type I transmembrane glycoprotein and is overexpressed in various epithelial tumor tissues. Some researchers have demonstrated that the glycosylation status of MUC1 can affect MUC1-mediated tumor growth and cell differentiation. In our previous study, we proved that the abilities of cell proliferation, adhesion, invasion and metastasis, and drug resistance were enhanced in ovarian cancer cells stably expressing Lewis(y). Therefore, we hypothesized that Lewis(y) antigen may play a central role in regulating MUC1 expression, and MUC1-mediated cell growth and differentiation may be closely associated with Lewis(y) antigen...
June 2, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28571024/elevated-preoperative-ca125-or-ca19-9-in-borderline-ovarian-tumors-could-it-be-suggestive-of-advanced-stage-or-a-poor-prognosis
#20
Taejong Song, Doo Haeng Lee, Yong Wook Jung, Bo Seong Yun, Seok Ju Seong, Chel Hun Choi, Jeong-Won Lee, Duk-Soo Bae, Byoung-Gie Kim
OBJECTIVES: To investigate whether elevated levels of CA125 (≥35 U/mL) and CA19-9 (≥37 U/mL) suggest advanced-stage disease (defined as stage II or higher) or poor prognosis in patients with borderline ovarian tumors (BOTs). STUDY DESIGN: We retrospectively identified 591 patients with BOTs. Multivariate logistic regressions and Cox proportional hazard regressions were used to determine the clinicopathologic factors associated with the presence of advanced-stage disease and the prognostic factors associated with recurrence-free survival...
June 2, 2017: Gynecologic and Obstetric Investigation
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