keyword
https://read.qxmd.com/read/38107473/surgical-treatment-of-a-very-rare-case-of-a-huge-intraligamental-leiomyoma-of-the-uterus-a-case-report-and-mini%C3%A2-review-of-the-literature
#21
Anna Thanasa, Efthymia Thanasa, Evangelos Kamaretsos, Vasiliki Grapsidi, Emmanouil Xydias, Apostolos Ziogas, Evangelos-Ektoras Gerokostas, Ioannis-Rafail Antoniou, Ioannis Paraoulakis, Ioannis Thanasas
Intraligamental leiomyomas of the uterus are rare. Extremely rare are the huge intraligamental fibroids (>20 cm), whose pre-operative diagnosis and surgical management poses a challenge to everyday clinical practice. The present study describes the case of patient who was subjected to surgical treatment for a huge intraligamental leiomyoma of the uterus, which weighed 3,370 g. A 48-year-old patient, without menstrual disorders and with a medical history of atypical symptoms from the digestive tract, was referred for a gynecological examination...
2024: Med Int (Lond)
https://read.qxmd.com/read/38078124/malignant-peripheral-nerve-sheath-tumor-with-hemophilic-syndrome-and-bone-marrow-fibrosis-a-rare-case-report
#22
Hui Li, Li Wang, Ying-Hong Wu, Gang Chen, Hong-Xia Li, Li-Fen Fan, Min Gu, Cai-Hong Jiang
BACKGROUND: Malignant schwannoma is a rare tumor in the peripheral nervous system, accounting for approximately 5% to 10% of systemic soft tissue sarcomas. Especially, malignant schwannoma occurring in the broad ligament of the uterus with hemophilic syndrome and bone marrow fibrosis is extremely rare in clinical practice. Here, we report the first case of an patient diagnosed with malignant peripheral nerve sheath tumor (MPNST) of the broad ligament of the uterus with hemophilic syndrome and bone marrow fibrosis, and share our reference clinical diagnosis and treatment experience...
November 6, 2023: World Journal of Clinical Cases
https://read.qxmd.com/read/38071714/laparoscopic-assisted-vaginal-trachelectomy-with-prophylactic-cerclage-a-safe-fertility-sparing-treatment-for-early-stage-cervical-cancer
#23
JOURNAL ARTICLE
Matteo Pavone, Marta Goglia, Giovanni Scambia, Denis Querleu, Cherif Akladios, Lise Lecointre
BACKGROUND: In recent years fertility-sparing treatments are increasingly developing in patients with early stage cervical cancer.1,2 Among these, trachelectomy represents a milestone with a wide range of surgical approaches,3 evidence of oncological safety, and positive obstetric outcomes.4 PATIENTS AND METHODS: A 26-year-old patient underwent conization for CIN3 with a subsequent diagnosis of squamous cervical cancer stage FIGO IB1. After a negative laparoscopic bilateral pelvic nodes sampling and the radiologic evidence [positron emission tomography-computed tomography (PET-CT) and magnetic resonance imaging (MRI)] of a disease limited to the cervix, the patient was a candidate for trachelectomy according to her fertility-sparing desire...
December 10, 2023: Annals of Surgical Oncology
https://read.qxmd.com/read/38023283/bacterial-dna-and-osteoarthritis-in-dogs-with-patellar-luxation-and-cranial-cruciate-ligament-rupture
#24
JOURNAL ARTICLE
Sirun Tuek-Um, Sarawut Yangtara, Win Surachetpong, Sarawan Kaewmongkol, Gunn Kaewmongkol, Naris Thengchaisri
BACKGROUND AND AIM: The association between bacterial DNA in stifle joints, including those with cranial cruciate ligament rupture (CCLR) and medial patellar luxation (MPL), and osteoarthritis in dogs remains elusive. This study investigated the potential association between the detection of bacterial DNA and osteoarthritis in dogs using a broad-range polymerase chain reaction technique targeting the 16S ribosomal RNA gene. MATERIALS AND METHODS: Synovial fluid (35 samples) and knee tissue samples (32 samples) were obtained from 35 dogs diagnosed with CCLR (n = 20; 11 males and nine females) or MPL (n = 15; five males and 10 females) who underwent a surgical operation between October 2014 and April 2015...
October 2023: Veterinary World
https://read.qxmd.com/read/38021650/postcoital-vaginal-laceration-in-a-nursing-mother-a-rarely-reported-entity
#25
Sudwita Sinha, Jyoti Singh, Mukta Agarwal, Indira Prasad
Postcoital vaginal injury is an uncommon entity in parous women, although it is a commonly encountered problem in virgins. Herein, we present a case of postcoital vaginal injury after consensual intercourse in a seven-month postpartum lactating woman, leading to a 5 cm laceration between the left lateral vaginal wall and posterior vaginal fornix. There was no evidence of colporrhexis. Ultrasonography was done to rule out any intraperitoneal collection or any broad ligament hematoma. The vaginal laceration was repaired in double layers...
October 2023: Curēus
https://read.qxmd.com/read/38020851/radiographic-cervical-spine-injury-patterns-in-admitted-blunt-trauma-patients-with-and-without-prehospital-spinal-motion-restriction
#26
JOURNAL ARTICLE
Susan Jao, Zhe Wang, Ambika Mukhi, Neeta Chaudhary, Jonathan Martin, Victoria Yuan, Robert Laskowski, Emily Huang, James Vosswinkel, Adam J Singer, Randeep Jawa
OBJECTIVES: Selective prehospital cervical spine motion restriction (C-SMR) following blunt trauma has increasingly been used by emergency medical service (EMS) providers. We determined rates of prehospital C-SMR and concomitant radiographic injury patterns. METHODS: A retrospective trauma registry and chart review was conducted for all adult blunt trauma patients who were transported by EMS and hospitalized with radiographic cervical spine injuries from 2011 to 2019 at a level 1 trauma center...
2023: Trauma Surgery & Acute Care Open
https://read.qxmd.com/read/38000678/malignant-female-genital-tract-smooth-muscle-tumors-with-adipocytic-differentiation-a-morphologic-immunohistochemical-mdm2-fluorescence-in-situ-hybridization-and-molecular-genetic-study-of-6-lipoleiomyosarcomas
#27
JOURNAL ARTICLE
Amy A Swanson, Michael Michal, Deyin Xing, Nooshin K Dashti, Vladimir Židlík, E Heidi Cheek-Norgan, Matthew E Keeney, Gary L Keeney, William R Sukov, Sounak Gupta, Marisa R Nucci, J Kenneth Schoolmeester
Leiomyosarcoma with adipocytic differentiation or lipoleiomyosarcoma is an uncommon sarcoma of the female genital tract with only a few individual reports in the literature. We therefore performed a morphologic, immunohistochemical, MDM2 gene amplification and RNA and DNA sequencing analysis of a series of gynecologic lipoleiomyosarcoma to better define the clinicopathologic spectrum. Six tumors from 6 patients were identified and classified as spindled lipoleiomyosarcoma (n = 2), mixed spindled and myxoid lipoleiomyosarcoma (n = 1), epithelioid lipoleiomyosarcoma with focal myxoid features (n = 1) and mixed spindled and epithelioid lipoleiomyosarcoma (n = 2)...
January 2024: Human Pathology
https://read.qxmd.com/read/38000508/thumb-basal-joint-arthritis-in-2023
#28
REVIEW
Lionel Athlani, Yoan-Kim De Almeida, Antoine Martins, Anne-Charlotte Seaourt, François Dap
Thumb carpometacarpal or basal joint arthritis is the second most common location for osteoarthritis in the hand. It mainly affects women over 50years of age. Basal joint arthritis causes pain, loss of strength during pinch grips, and eventually stiffness and progressive deformity of the thumb column. Conservative treatment must be implemented first. It aims to spare the joint by using standardized methods. It must be initiated as soon as pain starts, not once the deformity has settled in. There is broad agreement that surgery is indicated when pain relief is not achieved after at least 6months of conservative treatment...
November 22, 2023: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://read.qxmd.com/read/37986672/a-novel-extraperitoneal-cesarean-section-of-supravesical-approach-operative-techniques
#29
JOURNAL ARTICLE
Fumikazu Kotsuji, Sayoko Hosono, Shigeki Nishikawa, Takashi Shibata, Hiroki Kato, Satoshi Nakago, Tetsuya Oishi
AIM: We have established a novel extraperitoneal cesarean section technique by supravesical approach. An advantage of this technique over the conventional paravesical approach is that the lower uterine segment is broadly exposed and that all operative procedures can be performed under direct vision. We present the details of this novel technique. METHODS: The bladder and the peritoneum are exposed by removing the transversalis and extraperitoneal fasciae. Subsequently, a triangular area between the median umbilical ligament, the peritoneum, and the bladder is exposed...
November 20, 2023: Journal of Obstetrics and Gynaecology Research
https://read.qxmd.com/read/37980175/von-hippel-lindau-disease-related-neoplasia-with-an-emphasis-on-renal-manifestations
#30
REVIEW
Burak Tekin, Lori A Erickson, Sounak Gupta
von Hippel-Lindau (VHL) disease is characterized by biallelic inactivation of the VHL gene leading to abnormal or absent VHL protein function, and constitutive activation of hypoxia-inducible factors (HIF) that leads to pro-tumorigenic signaling. Individuals with VHL disease develop numerous cysts and tumors involving multiple organs including the kidneys, central nervous system, endolymphatic sac, lungs, pancreatobiliary system, adrenal glands, epididymis, and/or broad ligament. On histologic examination, these lesions show morphologic overlap as they are frequently characterized by cells with clear cytoplasm and prominent vascularity...
November 8, 2023: Seminars in Diagnostic Pathology
https://read.qxmd.com/read/37978859/polycaprolactone-based-scaffolds-for-guided-tissue-regeneration-in-periodontal-therapy-a-systematic-review
#31
REVIEW
Florencia Antunovic, Felipe Tolosa, Catherine Klein, René Ocaranza
BACKGROUND: Polycaprolactone (PCL) is a highly recognized synthetic polymer for its biocompatibility, ease of fabrication and mechanical strength in bone tissue engineering. Its applications have extended broadly, including regeneration of oral and maxillofacial lost tissues. Its usefulness has brought attention of researchers to regenerate periodontal lost tissues, including alveolar bone, periodontal ligament and cementum. The aim of this systematic review was to obtain an updated analysis of the contribution of PCL-based scaffolds in the alveolar bone regeneration process...
2023: Journal of Applied Biomaterials & Functional Materials
https://read.qxmd.com/read/37972871/benign-female-genital-tract-smooth-muscle-tumors-with-adipocytic-differentiation-a-morphologic-immunohistochemical-and-mdm2-fluorescence-in-situ-hybridization-study-of-44-conventional-lipoleiomyomas-and-lipoleiomyoma-variants
#32
JOURNAL ARTICLE
Amy A Swanson, Michael Michal, Deyin Xing, Vladimir Židlík, E Heidi Cheek-Norgan, Matthew E Keeney, Gary L Keeney, William R Sukov, Sounak Gupta, Marisa R Nucci, J Kenneth Schoolmeester
Leiomyomas with adipocytic differentiation typically occur in the uterus although they may arise at several sites in the female genital tract. While these are most commonly spindled leiomyomas with a component of adipocytic tissue ("conventional lipoleiomyomas"), there is a relatively ill-defined assortment of leiomyoma variants with adipocytic differentiation. We performed a morphologic, immunohistochemical and MDM2 gene amplification analysis of a large series of gynecologic leiomyomas with adipocytic differentiation to better define the clinicopathologic spectrum...
November 14, 2023: Human Pathology
https://read.qxmd.com/read/37891563/anatomical-investigation-of-the-pelvic-urogenital-fascia-in-10-formalin-fixed-female-cadavers-novel-insights-into-the-laparoscopic-total-mesometrial-resection
#33
JOURNAL ARTICLE
Zheqi Zhou, Bin Li, Jinsong Zhou, Yanbing Ma, Yang Zhao, Cong Tong, Hui Wang, Dian Jin, Yujie Li, Likun Yan
PURPOSE: Previous anatomical studies of the urogenital fascia (UGF) have focused on males, and there is a lack of relevant anatomical studies on the distribution of the extraperitoneal UGF in females. METHODS: In this investigation, guided by the embryonic development of the female urogenital system, the ventral pelvic fascia structure of 10 female cadavers was dissected, and the distribution and morphology of female extraperitoneal UGF were observed, recorded in text, photographs and video, and 3D modeling was performed...
October 27, 2023: BMC Surgery
https://read.qxmd.com/read/37883876/secondary-postpartum-hemorrhage-due-to-uterine-scar-dehiscence-a-case-report
#34
Fathi Mraihi, Jihene Basly, Amani Mezni, Zeineb Ghali, Montasar Hafsi, Dalenda Chelli
INTRODUCTION: Secondary postpartum hemorrhage is rare. The most common cause is retained placenta. Having a uterine scar dehiscence as an etiology is unusual. Complete dehiscence of the uterine scar is even rarer. This rare but serious cause of post-partum haemorrhage can be potentially life threatening due to severe hemorrhage if not managed in adequate time. PRESENTATION OF CASE: We present the case of a 35-year-old patient, gravida 2 para 2. She had undergone two caesarean sections in our department and, after the last one in March 2021, she presented twice to our emergency department with relatively abundant metrorrhagia, but neither the clinical nor the radiological examinations revealed any abnormalities...
October 1, 2023: International Journal of Surgery Case Reports
https://read.qxmd.com/read/37873464/synovial-macrophage-diversity-and-activation-of-m-csf-signaling-in-post-traumatic-osteoarthritis
#35
Alexander J Knights, Easton C Farrell, Olivia M Ellis, Michelle J Song, C Thomas Appleton, Tristan Maerz
OBJECTIVE: Synovium is home to immune and stromal cell types that orchestrate inflammation following a joint injury; in particular, macrophages are central protagonists in this process. We sought to define the cellular and temporal dynamics of the synovial immune niche in a mouse model of post-traumatic osteoarthritis (PTOA), and to identify stromal-immune crosstalk mechanisms that coordinate macrophage function and phenotype. DESIGN: We induced PTOA in mice using a non-invasive tibial compression model of anterior cruciate ligament rupture (ACLR)...
October 5, 2023: bioRxiv
https://read.qxmd.com/read/37869116/high-resolution-finger-mri-what-should-you-look-for-in-trauma-of-the-fingers
#36
REVIEW
Kyoung Yeon Lee, Jiwon Rim, Jung-Ah Choi, Eun Kyung Khil
The fingers are among the most commonly injured structures in traumatic injuries resulting from sports and work. Finger injuries encompass a broad spectrum of injuries to bone and soft tissues, including tendons, ligaments, and cartilage. The high resolution of 3T MRI with dedicated surface coils allows for optimal assessment of the intricate soft tissue structures of the fingers. There have been several reports on detailed MRI features of the basic anatomy and common pathological findings of the finger and hand...
September 2023: J Korean Soc Radiol
https://read.qxmd.com/read/37842095/curcumin-primed-periodontal-ligament-stem-cells-derived-extracellular-vesicles-improve-osteogenic-ability-through-the-wnt-%C3%AE-catenin-pathway
#37
JOURNAL ARTICLE
Qian Lan, Jiadong Cao, Xueting Bi, Xin Xiao, Dongsheng Li, Yilong Ai
Introduction: Curcumin has broad application prospects in the prevention and treatment of periodontal diseases. Periodontal ligament stem cell-derived extracellular vesicles (PDLSC-EV) can effectively promote periodontal tissue regeneration and possess good drug delivery capability. Superior pharmacological effects can be exerted using PDLSC-EV as a curcumin carrier. Methods: In the present study, we constructed curcumin-primed PDLSCs-derived extracellular vesicles (Cur-PDLSC-EV) from cell culture supernatants of curcumin-pretreated PDLSCs by ultracentrifugation and investigated their effects on the proliferation, migration, and osteogenic ability of PDLSCs and the corresponding downstream molecular pathways...
2023: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/37822903/structural-investigations-of-au-ni-aerogels-morphology-and-element-distribution
#38
JOURNAL ARTICLE
Johannes Kresse, Maximilian Georgi, René Hübner, Alexander Eychmüller
The physical properties of nanomaterials are determined by their structural features, making accurate structural control indispensable. This carries over to future applications. In the case of metal aerogels, highly porous networks of aggregated metal nanoparticles, such precise tuning is still largely pending. Although recent improvements in controlling synthesis parameters like electrolytes, reductants, or mechanical stirring, the focus has always been on one particular morphology at a time. Meanwhile, complex factors, such as morphology and element distributions, are studied rather sparsely...
October 10, 2023: Nanoscale advances
https://read.qxmd.com/read/37796636/deciphering-the-art-in-modeling-and-simulation-of-the-knee-joint-assessing-model-calibration-workflows-and-outcomes
#39
JOURNAL ARTICLE
Thor E Andreassen, Peter J Laz, Ahmet Erdemir, Thor F Besier, Jason P Halloran, Carl Imhauser, Snehal Chokhandre, Ariel Schwartz, Neda Abdollahi Nohouji, Nynke Rooks, Marco T Y Schneider, Shady Elmasry, William Zaylor, Donald Hume, Kevin B Shelburne
Model reproducibility is a point of emphasis for the National Institutes of Health (NIH) and in science, broadly. As the use of computational modeling in biomechanics and orthopaedics grows, so does the need to assess the reproducibility of modeling workflows and simulation predictions. The long-term goal of the KneeHub project is to understand the influence of potentially subjective decisions, thus the modeler's "art", on the reproducibility and predictive uncertainty of computational knee joint models. In this paper, we report on the model calibration phase of this project, during which five teams calibrated computational knee joint models of the same specimens from the same specimen-specific joint mechanics dataset...
October 5, 2023: Journal of Biomechanical Engineering
https://read.qxmd.com/read/37733198/therapeutic-potential-of-oral-derived-mesenchymal-stem-cells-in-retinal-repair
#40
REVIEW
Fariba Mohebichamkhorami, Zahra Niknam, Hakimeh Zali, Ebrahim Mostafavi
The retina has restricted regeneration ability to recover injured cell layer because of reduced production of neurotrophic factors and increased inhibitory molecules against axon regrowth. A diseased retina could be regenerated by repopulating the damaged tissue with functional cell sources like mesenchymal stem cells (MSCs). The cells are able to release neurotrophic factors (NFs) to boost axonal regeneration and cell maintenance. In the current study, we comprehensively explore the potential of various types of stem cells (SCs) from oral cavity as promising therapeutic options in retinal regeneration...
September 21, 2023: Stem cell reviews and reports
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