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https://www.readbyqxmd.com/read/29315551/the-impact-of-artificial-selection-on-morphological-integration-in-the-appendicular-skeleton-of-domestic-horses
#1
Pauline Hanot, Anthony Herrel, Claude Guintard, Raphaël Cornette
The relationships between the different component parts of organisms, such as the sharing of common development or function, produce a coordinated variation between the different traits. This morphological integration contributes to drive or constrain morphological variation and thus impacts phenotypic diversification. Artificial selection is known to contribute significantly to phenotypic diversification of domestic species. However, little attention has been paid to its potential impact on integration patterns...
January 8, 2018: Journal of Anatomy
https://www.readbyqxmd.com/read/29311146/impact-of-broad-regulatory-regions-on-gdf5-expression-and-function-in-knee-development-and-susceptibility-to-osteoarthritis
#2
Steve K Pregizer, Ata M Kiapour, Mariel Young, Hao Chen, Michael Schoor, Zun Liu, Jiaxue Cao, Vicki Rosen, Terence D Capellini
OBJECTIVES: Given the role of growth and differentiation factor 5 (GDF5) in knee development and osteoarthritis risk, we sought to characterise knee defects resulting from Gdf5 loss of function and how its regulatory regions control knee formation and morphology. METHODS: The brachypodism (bp) mouse line, which harbours an inactivating mutation in Gdf5, was used to survey how Gdf5 loss of function impacts knee morphology, while two transgenic Gdf5 reporter bacterial artificial chromosome mouse lines were used to assess the spatiotemporal activity and function of Gdf5 regulatory sequences in the context of clinically relevant knee anatomical features...
January 8, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29288856/risk-factors-and-management-of-dural-defects-in-anterior-surgery-for-cervical-ossification-of-the-posterior-longitudinal-ligament
#3
Yue-Qi Du, Wan-Ru Duan, Zan Chen, Hao Wu, Feng-Zeng Jian
OBJECTIVE: To investigate risk factors and outcomes and to develop a cogent perioperative management algorithm for dural defects (DDs) in anterior surgery for cervical ossification of the posterior longitudinal ligament (OPLL). METHODS: Ninety OPLL patients underwent anterior cervical decompression between January 2014 and December 2016 were reviewed. DDs occurred in 12 patients. Demographic, clinical and radiological data; intra- and postoperative management; and complications were analyzed...
December 27, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29251572/a-soft-gripper-with-rigidity-tunable-elastomer-strips-as-ligaments
#4
Amir Mohammadi Nasab, Amin Sabzehzar, Milad Tatari, Carmel Majidi, Wanliang Shan
Like their natural counterparts, soft bioinspired robots capable of actively tuning their mechanical rigidity can rapidly transition between a broad range of motor tasks-from lifting heavy loads to dexterous manipulation of delicate objects. Reversible rigidity tuning also enables soft robot actuators to reroute their internal loading and alter their mode of deformation in response to intrinsic activation. In this study, we demonstrate this principle with a three-fingered pneumatic gripper that contains "programmable" ligaments that change stiffness when activated with electrical current...
December 2017: Soft Robotics
https://www.readbyqxmd.com/read/29234557/the-diagnostic-accuracy-of-the-lever-sign-for-detecting-anterior-cruciate-ligament-injury
#5
Edward P Mulligan, Amanda Anderson, Seth Watson, Robert J Dimeff
Background: An alternative physical examination procedure for evaluating the integrity of the anterior cruciate ligament (ACL) has been proposed in the literature but has not been validated in a broad population of patients with a symptomatic complaint of knee pain for its diagnostic value. Purpose: To investigate the diagnostic accuracy of the Lever Sign to detect ACL tears and compare the results to Lachman testing in both supine and prone positions. Study design: Prospective, blinded, diagnostic accuracy study...
December 2017: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/29207066/erythropoietin-induces-the-osteogenesis-of-periodontal-mesenchymal-stem-cells-from-healthy-and-periodontitis-sources-via-activation-of-the-p38-mapk-pathway
#6
Liying Wang, Fan Wu, Yang Song, Yinzhong Duan, Zoulin Jin
Erythropoietin (Epo), a hematopoietic hormone, has multiple biological functions. Recently, the positively osteogenic effects of Epo on mesenchymal stem cells (MSCs) have attracted broad interest. However, the effects of Epo on the osteogenesis of human periodontal ligament tissue‑derived mesenchymal stem cells (hPDLSCs) and periodontitis mesenchymal stem cells (pPDLSCs) from patients with periodontitis remain unknown. In the present study, osteogenic effects of Epo on hPDLSCs and pPDLSCs were investigated, and the results suggested that the effects were mediated by promoting the expression of runt related transcription factor 2, alkaline phosphatase (ALP) and osteocalcin...
November 28, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29173559/anterolateral-ligament-reconstruction-or-extra-articular-tenodesis-why-and-when
#7
REVIEW
Manoj Mathew, Aad Dhollander, Alan Getgood
Residual rotational laxity following anterior cruciate ligament (ACL) reconstruction has been identified as significant concern in many patients, despite evolution of techniques. The expanding body of knowledge on the anatomy and biomechanics of the anterolateral soft tissue restraints in rotational control of the knee has reignited an interest in extra-articular reconstruction techniques for augmenting ACL reconstruction. Reconstruction techniques currently used can be broadly categorized as either lateral extra-articular tenodesis or reconstruction of the anterolateral ligament...
January 2018: Clinics in Sports Medicine
https://www.readbyqxmd.com/read/29163219/neuromuscular-training-improves-lower-extremity-biomechanics-associated-with-knee-injury-during-landing-in-11-13-year-old-female-netball-athletes-a-randomized-control-study
#8
Amanda J Hopper, Erin E Haff, Christopher Joyce, Rhodri S Lloyd, G Gregory Haff
The purpose of this study was to examine the effects of a neuromuscular training (NMT) program on lower-extremity biomechanics in youth female netball athletes. The hypothesis was that significant improvements would be found in landing biomechanics of the lower-extremities, commonly associated with anterior cruciate ligament (ACL) injury, following NMT. Twenty-three athletes (age = 12.2 ± 0.9 years; height = 1.63 ± 0.08 m; mass = 51.8 ± 8.5 kg) completed two testing sessions separated by 7-weeks and were randomly assigned to either a experimental or control group...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29133151/laparoscopic-management-of-a-rudimentary-uterine-horn
#9
Emilie Faller, Jean Jacques Baldauf, François Becmeur, Anne Lehn, Cherif Youssef Akladios, Lise Lecointre
STUDY OBJECTIVE: To demonstrate a technique of laparoscopic management of a rudimentary horn in a 12-year-old girl. DESIGN: A step-by-step explanation of the surgery using video (instructive video), approved the local institutional Review Board. SETTING: A university hospital, University Hospital of Strasbourg, France. PATIENT: A 12-year-old girl with a uterine rudimentary horn. INTERVENTION: We describe the case of a 12 years old girl who had no medical history...
November 10, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29115064/broad-ligament-hernia-successfully-repaired-by-single-incision-laparoscopy-a-case-report
#10
Hiroshi Takeyama, Yuya Kogita, Takahiko Nishigaki, Masafumi Yamashita, Eriko Aikawa, Minako Hoshi, Hirokazu Taniguchi, Yasuki Maruyama, Kazuhiro Nakajima, Yoshimitsu Yamamoto, Kazushige Adachi, Hitoshi Yamamoto, Kimimasa Ikeda, Eiji Kurokawa
A 52-year-old woman with a history of two parturitions presented with lower abdominal pain. Multi-detector CT of the abdomen showed discontinuity of the sigmoid colon near the broad ligament on the left side. We assigned a provisional diagnosis of an internal hernia progressing through a defect in the broad ligament. SILS revealed a total broad ligament defect on the left side but no signs of ischemic, necrotic bowel. We successfully repaired the broad ligament defect with suturing. At the 2-month follow-up, the patient remained well with no signs of recurrence...
November 8, 2017: Asian Journal of Endoscopic Surgery
https://www.readbyqxmd.com/read/29114335/imaging-of-the-unstable-shoulder
#11
Paolo Baudi, Manuela Rebuzzi, Giovanni Matino, Fabio Catani
Background: Unstable shoulder can occur in different clinical scenarios with a broad spectrum of symptoms and presentations: first-time (or recurrent) traumatic acute shoulder anterior dislocation or chronic anterior instability after repeated dislocations.Imaging in unstable shoulder is fundamental for choosing the right treatment preventing recurrence.The goal of imaging depends on clinical scenario and patient characteristics. Method: Careful selection and evaluation of the imaging procedures is therefore essential to identify, characterize and quantify the lesions...
2017: Open Orthopaedics Journal
https://www.readbyqxmd.com/read/29076695/broad-ligament-haematoma-following-normal-vaginal-delivery
#12
Faiza Ibrar, Azra Saeed Awan, Touseef Fatima, Hina Tabassum
A 37-year-old, patient presented in emergency with history of normal vaginal delivery followed by development of abdominal distention, vomiting, constipation for last 3 days. She was para 4 and had normal vaginal delivery by traditional birth attendant at peripheral hospital 3 days back. Imaging study revealed a heterogeneous complex mass, ascites, pleural effusion, air fluid levels with dilatation gut loops. Based upon pelvic examination by senior gynaecologist in combination with ultrasound; a clinical diagnosis of broad ligament haematoma was made...
July 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/29037192/retroperitoneal-ectopic-pregnancy-a-case-report-and-review-of-the-literature
#13
Man Yang, Lamu Cidan, Dan Zhang
BACKGROUND: Retroperitoneal ectopic pregnancy (REP) is an extremely rare type of ectopic pregnancy, with a total of less than 20 cases reported in the English literature. However, failure to recognize REP may result in severe consequences. CASE PRESENTATION: We report a case of 32-year-old woman with REP. She had amenorrhea, left lower abdominal pain, but no vaginal bleeding. Her urine human chorionic gonadotropin (HCG) test was positive and blood HCG level was 1880 m-international units per milliliter (mIU/mL)...
October 16, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29033397/a-transvaginal-endoscopy-based-technique-for-performing-ovarian-examinations-in-sows
#14
Minami W Okuyama, Tomochika Sugiura, Masaharu Moriyoshi, Kazuto Yamashita, Jun Tamura, Seiji Katagiri
For examining pig ovaries, which have complex structures, laparoscopy is a useful technique, but requires general anesthesia; therefore, it cannot be performed repeatedly within a short period of time. We report a transvaginal endoscopy-based technique for conducting ovarian examinations without general anesthesia. Sows were sedated in pig stalls. Using a colonoscope, the vaginal wall was punctured with a trocar. To avoid the trocar being caught in the broad ligament of the uterus or the connective tissue around the vagina, the trocar was inserted close to the external uterine os and between the 2:00 and 3:00 or the 9:00 and 10:00 positions (in a clockwise direction)...
October 14, 2017: Journal of Reproduction and Development
https://www.readbyqxmd.com/read/29026520/work-related-musculoskeletal-injuries-sustained-by-australian-osteopaths-qualitative-analysis-of-effects-on-practitioner-health-clinical-practice-and-patient-care
#15
Gopi Anne McLeod, Katerina Annels, Jessica Cohen, Samuel Edwards, Daniel Hodgins, Brett Vaughan
BACKGROUND: There is limited literature that explores the experiences of osteopaths injured while engaging in clinical practice. Evidence from other similar health professions has described the numerous effects of work-related musculoskeletal injuries (WRMI). Work-related musculoskeletal injury refers to trauma to joints, ligaments, muscles and tendons resulting from injury sustained while undertaking work duties. This research aimed to gain a contextualised understanding of the experiences of osteopaths who have sustained a work-related musculoskeletal injury while performing clinical practice...
2017: Chiropractic & Manual Therapies
https://www.readbyqxmd.com/read/29022557/two-childhood-pheochromocytoma-cases-due-to-von-hippel-lindau-disease-one-associated-with-pancreatic-neuroendocrine-tumor-a-rare-manifestation
#16
Aydilek Dağdeviren Çakır, Hande Turan, Ayça Aykut, Asude Durmaz, Oya Ercan, Olcay Evliyaoğlu
(VHL) disease is an autosomal dominantly inherited disorder characterized by hemangioblastomas of retina and central nervous system (CNS); renal cysts, clear cell carcinoma; PCC; endolymphatic sac tumors; cystadenomas of the epididymis in males, broad ligament of uterus in females; pancreatic cysts, cystadenomas and neuroendocrine tumors. We here report two cases of VHL disease presented with PCC as the first manifestation. Hemangioblastoma of CNS in the first case and PNET in the second case developed during follow- up and led to the diagnosis of VHL disease...
October 12, 2017: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/28981378/morinda-citrifolia-leaf-extract-enhances-osteogenic-differentiation-through-activation-of-wnt-%C3%AE-catenin-signaling
#17
Hanna Gu, Kanitsak Boonanantanasarn, Moonkyu Kang, Ikhwi Kim, Kyung Mi Woo, Hyun-Mo Ryoo, Jeong-Hwa Baek
Morinda citrifolia (Noni) leaf is an herbal medicine with application in the domestic treatment of a broad range of conditions, including bone fracture and luxation. However, the basic mechanism underlying the stimulation of osteogenic differentiation by Noni leaf extract remains poorly understood. This study aimed to examine the effect of this extract on osteogenic differentiation and the mechanism by which Noni leaf extract enhances osteogenic differentiation. Aqueous extract of Noni leaves was prepared, and rutin and kaempferol-3-O-rutinoside were identified to be two of its major components...
October 5, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28975020/a-case-of-neuroendocrine-carcinoma-developing-from-the-broad-ligament-of-the-uterus
#18
Yui Itonaga, Masakazu Nishida, Harunobu Matsumoto, Kaei Nasu, Hisashi Narahara
Neuroendocrine carcinoma (NEC), also called small cell carcinoma or large cell carcinoma, is a rare and aggressive tumor that develops mainly in the lung and intestine. More rarely, NEC develops in gynecologic organs, with poor prognoses. We experienced a case of NEC in the broad ligament of the uterus. The patient was a 74-year-old woman with symptoms of abdominal distension and constipation. Ultrasound sonography detected an abdominal tumor larger than 10 cm. She was then admitted to our hospital. She underwent surgery under the diagnosis of ovarian cancer, but the bilateral ovaries and uterus were normal in appearance, and a tumor was developing instead from the broad ligament of the uterus...
July 3, 2017: Rare Tumors
https://www.readbyqxmd.com/read/28974911/two-phase-laparoendoscopic-single-site-cervical-ligament-sparing-hysterectomy-an-initial-experience
#19
Mun-Kun Hong, Tang-Yuan Chu, Jen-Huang Wang, Dah-Ching Ding
OBJECTIVE: To report our initial experience with and the short-term outcomes of two-phase laparoendoscopic single-site cervical ligament-sparing hysterectomy (LESS-CLSH). MATERIALS AND METHODS: A retrospective case study included 40 women who underwent LESS-CLSH from January 2014 to December 2016 at Buddhist Tzu Chi General Hospital. Uterine specimens were extracted through contained manual morcellation with a tissue pouch. The first phase was LESS supracervical hysterectomy and conization of the internal orifice of the cervix...
July 2017: Ci Ji Yi Xue za Zhi, Tzu-chi Medical Journal
https://www.readbyqxmd.com/read/28974333/effect-of-the-timing-of-anterior-cruciate-ligament-reconstruction-on-clinical-and-stability-outcomes-a%C3%A2-systematic-review-and-meta-analysis
#20
Yong Seuk Lee, O-Sung Lee, Seung Hoon Lee, Teo Seow Hui
PURPOSE: The purpose of this systematic review and meta-analysis was to evaluate the effect of the timing of anterior cruciate ligament (ACL) reconstruction on clinical and stability outcomes by analyzing high-quality studies that assessed timing as a primary objective. METHODS: The MEDLINE, EMBASE, and Cochrane database were systematically searched. The inclusion criteria were as follows: (1) English articles, (2) noncomparative study or relevant study reporting clinical and/or stability results, and (3) timing of the ACL reconstruction as a primary objective...
September 30, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
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