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https://www.readbyqxmd.com/read/28728324/the-chicken-thigh-adductor-profundus-free-muscle-flap-a-novel-validated-non-living-microsurgery-simulation-training-model
#1
Georgios Pafitanis, Yasmine Serrar, Maria Raveendran, Ali Ghanem, Simon Myers
BACKGROUND: Simulation training is becoming an increasingly important component of skills acquisition in surgical specialties, including Plastic Surgery. Non-living simulation models have an established place in Plastic Surgical microsurgery training, and support the principles of replacement, reduction and refinement of animal use. A more sophisticated version of the basic chicken thigh microsurgery model has been developed to include dissection of a type 1-muscle flap and is described and validated here...
July 2017: Archives of Plastic Surgery
https://www.readbyqxmd.com/read/28728087/surface-imprinted-bacterial-cellulose-nanofibers-for-hemoglobin-purification
#2
Monireh Bakhshpour, Emel Tamahkar, Müge Andaç, Adil Denizli
There is a significant need for the development of the novel adsorbents in the field of protein purification. In this study, thin hemoglobin imprinted film (MIP) was fabricated onto the bacterial cellulose nanofibers' (BCNFs) by surface imprinting method using metal ion coordination interactions with N-methacryloyl-(L)-histidinemethylester (MAH) and copper ions. The hemoglobin surface imprinted bacterial cellulose nanofibers (MIP-BCNFs) was applied to selective recognition of hemoglobin and purification from hemolysate...
July 10, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28728043/autofocus-on-moving-object-in-scanning-electron-microscope
#3
Andrey V Kudryavtsev, Sounkalo Dembélé, Nadine Piat
The sharpness of the images coming from a Scanning Electron Microscope (SEM) is a very important property for many computer vision applications at micro- and nanoscale. It represents how much object details are distinctive in the images: the object may be perceived sharp or blurred. Image sharpness highly depends on the value of focal distance, or working distance in the case of the SEM. Autofocus is the technique allowing to automatically adjust the working distance to maximize the sharpness. Most of the existing algorithms allows working only with a static object which is enough for the tasks of visualization, manual microanalysis or microcharacterization...
July 12, 2017: Ultramicroscopy
https://www.readbyqxmd.com/read/28727847/outstanding-micro-endemism-in-new-caledonia-more-than-one-out-of-ten-animal-species-have-a-very-restricted-distribution-range
#4
Maram Caesar, Philippe Grandcolas, Roseli Pellens
New Caledonia is a biodiversity hotspot, with an extremely high number of endemic species with narrow distribution ranges that are at high risk of extinction due to open-cast nickel mining, invasive species and seasonal man-induced fires. Mentions of micro-endemism permeate the literature on the biota of this archipelago. However, so far there has been no research comparing distribution range in different animal groups. The aim of this study is to examine the implication of different sampling effort variables in order to distinguish micro-endemicity from data deficiency, and evaluate the distribution range, frequency, and extent to which micro-endemism is common to several groups of organisms...
2017: PloS One
https://www.readbyqxmd.com/read/28727765/defining-the-target-and-the-effect-of-imatinib-on-the-filarial-c-abl-homologue
#5
Elise M O'Connell, Olena Kamenyeva, Sara Lustigman, Aaron Bell, Thomas B Nutman
BACKGROUND: Previously we demonstrated the micro- and macrofilaricidal properties of imatinib in vitro. Here we use electron and multiphoton microscopy to define the target of imatinib in the adult and microfilarial stages of Brugia malayi, and assess the effects of pharmacologically relevant levels of imatinib on the adult parasites. METHODS: After fixation of adult B. malayi males and females, sections were stained with polyclonal rabbit anti-c-Abl antibody (or isotype control) and imaged with multiphoton fluorescent microscopy...
July 20, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28727746/atorvastatin-reduces-%C3%AE-adrenergic-dysfunction-in-rats-with-diabetic-cardiomyopathy
#6
Aude Carillion, Sarah Feldman, Na Na, Matthieu Biais, Wassila Carpentier, Aurélie Birenbaum, Nicolas Cagnard, Xavier Loyer, Dominique Bonnefont-Rousselot, Stéphane Hatem, Bruno Riou, Julien Amour
BACKGROUND: In the diabetic heart the β-adrenergic response is altered partly by down-regulation of the β1-adrenoceptor, reducing its positive inotropic effect and up-regulation of the β3-adrenoceptor, increasing its negative inotropic effect. Statins have clinical benefits on morbidity and mortality in diabetic patients which are attributed to their "pleiotropic" effects. The objective of our study was to investigate the role of statin treatment on β-adrenergic dysfunction in diabetic rat cardiomyocytes...
2017: PloS One
https://www.readbyqxmd.com/read/28727688/diazepam-actions-in-the-vta-enhance-social-dominance-and-mitochondrial-function-in-the-nucleus-accumbens-by-activation-of-dopamine-d1-receptors
#7
M A van der Kooij, F Hollis, L Lozano, I Zalachoras, S Abad, O Zanoletti, J Grosse, I Guillot de Suduiraut, C Canto, C Sandi
Benzodiazepines can ameliorate social disturbances and increase social competition, particularly in high-anxious individuals. However, the neural circuits and mechanisms underlying benzodiazepines' effects in social competition are not understood. Converging evidence points to the mesolimbic system as a potential site of action for at least some benzodiazepine-mediated effects. Furthermore, mitochondrial function in the nucleus accumbens (NAc) has been causally implicated in the link between anxiety and social competitiveness...
July 20, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28727390/use-of-indocyanine-green-angiography-in-microsurgical-subinguinal-varicocelectomy-lessons-learned-from-our-initial-experience
#8
Chak-Lam Cho, Kwan-Lun Ho, Wayne Kwun-Wai Chan, Ringo Wing-Hong Chu, In-Chak Law
Microsurgical subinguinal varicocelectomy (MSV) is generally considered the gold standard nowadays in view of the lower risk of complications and recurrence. To achieve complete ligation of veins while preserving testicular artery (TA) during the procedure remains challenging despite the application of high power optical magnification and micro-Doppler ultrasonography. The use of intraoperative indocyanine green angiography (ICGA) with infrared fluorescence operative micro-scope in MSV potentially lowers the incidence of TA injury and shortens the learning curve of nov-ice surgeons...
July 20, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28727342/-obesity-fat-and-bones-friends-or-foes
#9
Emmanuel Biver
Low fat mass is associated with an increased risk of fracture because of low bone mineral density (BMD) and altered bone micro-architecture. Conversely, overweight and obese patients also have an increased risk of fracture, particularly of the humerus and ankle, despite greater BMD. Visceral abdominal fat, which is the most metabolically active, may be associated with poorer quality of bone tissue properties, as suggested in diabetes. Other factors may contribute to higher fracture risk in overweight patients, notably higher frequency of falls and lower bioavailability of vitamin D stoked in fat...
April 19, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28727319/novel-evaluation-and-treatment-techniques-for-white-spot-lesions-an-in-vitro-study
#10
T A Bakhsh, A S Bakry, M M Mandurah, M A Abbassy
OBJECTIVE: White spot lesions (WSLs) are commonly seen during and after orthodontic treatment. Therefore, the objective of this in vitro study was to assess the effect of 45S5-bioglass in remineralizing WSLs using cross-polarization optical coherence tomography (CP-OCT) and confirm the findings by micro-hardness test. METHODS: Ceramic orthodontic brackets were bonded to the buccal surface of 45 human premolars with Transbond XT primer followed by Transbond PLUS according to the manufacturer's instructions...
August 2017: Orthodontics & Craniofacial Research
https://www.readbyqxmd.com/read/28727297/parsel-parallel-selection-of-micro-rnas-for-survival-classification-in-cancers
#11
Debajyoti Sinha, Debarka Sengupta, Sanghamitra Bandyopadhyay
It is known that tumor micro-RNAs (miRNA) can define patient survival and treatment response. We present a framework to identify miRNAs which are predictive of cancer survival. The framework attempts to rank the miRNAs by exploring their collaborative role in gene regulation. Our approach tests a significantly large number of combinatorial cases leveraging parallel computation. We carefully avoided parametric assumptions involved in evaluations of miRNA expressions but used rigorous statistical computation to assign an importance score to a miRNA...
July 2017: Molecular Informatics
https://www.readbyqxmd.com/read/28727264/phosphorylated-polyacrylonitrile-fiber-as-an-efficient-and-greener-acetalization-catalyst
#12
Gang Xu, Jian Cao, Yali Zhao, Lishuo Zheng, Minli Tao, Wenqin Zhang
A novel solid acid catalyst (PANEAPF) was developed by immobilization of phosphoric acid on polyacrylonitrile fiber via covalent bond. Various characterization techniques such as elemental analysis (EA), X-ray photoelectron spectroscopy (XPS), Fourier transform infrared spectroscopy (FTIR), etc. were utilized to confirm the successful grafting and the stability of the fiber catalysts during application. The PANEAPF showed high catalytic activity in the acetalization of aldehydes due to the high utilization efficiency of its functionalized acid sites...
July 20, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28727251/degree-of-conversion-and-cross-link-density-within-a-resin-matrix-composite
#13
Afnan O Al-Zain, George J Eckert, Henry Lukic, Spiro J Megremis, Jeffrey A Platt
The aims of this study were to profile light radiated from two light-curing units (LCUs) and evaluate profile relationship to polymerization patterns within a resin-matrix composite (RMC). Beam profiles of one multiple emission peak light-emitting-diode and one quartz-tungsten-halogen curing-unit were measured using a beam profiler/spectrometer system. A camera-based profiler and an integrating sphere/spectrometer assembly were used to evaluate each LCU beam. Polymerization patterns within a nano-hybrid RMC were investigated using a mapping approach by assessing the degree of conversion utilizing micro-Raman spectroscopy and indirectly estimating cross-link-density by repeated microhardness testing before and after exposure to ethanol (%KH reduction, n = 3)...
July 20, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28727234/kynurenine-a-tryptophan-metabolite-that-accumulates-with-age-induces-bone-loss
#14
Mona El Refaey, Meghan E McGee-Lawrence, Sadanand Fulzele, Eileen J Kennedy, Wendy B Bollag, Mohammed Elsalanty, Qing Zhong, Ke-Hong Ding, Nathaniel G Bendzunas, Xing-Ming Shi, Jianrui Xu, William D Hill, Maribeth H Johnson, Monte Hunter, Jessica L Pierce, Kanglun Yu, Mark W Hamrick, Carlos M Isales
Age-dependent bone loss occurs in humans and in several animal species, including rodents. The underlying causal mechanisms are probably multifactorial, although an age-associated increase in the generation of reactive oxygen species has been frequently implicated. We previously reported that aromatic amino acids function as antioxidants and are anabolic for bone and that they may potentially play a protective role in an aging environment. We hypothesized that upon oxidation the aromatic amino acids would not only lose their anabolic effects but also potentially become a catabolic byproduct...
July 20, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28726962/recent-advances-in-functional-mesoporous-graphitic-carbon-nitride-mpg-c3n4-polymers
#15
REVIEW
Shaodong Sun, Shuhua Liang
Mesoporous micro-/nanostructures acting as supports for catalysts or used directly in catalysis reactions generally show fascinating performances that could lead to great potential for application. In the past few decades, extensive efforts have been devoted to the exploration and enrichment of graphitic carbon nitride (g-C3N4) based research. Especially, mesoporous g-C3N4 (mpg-C3N4) with controllable porosity and electronic/atomic structure can bring to bear unique physicochemical properties and has been widely applied in the fields of photocatalysis, adsorbents, sensors and chemical templates...
July 20, 2017: Nanoscale
https://www.readbyqxmd.com/read/28726923/robust-manufacturing-of-lipid-polymer-nanoparticles-through-feedback-control-of-parallelized-swirling-microvortices
#16
Michael J Toth, Taeyoung Kim, YongTae Kim
A variety of therapeutic and/or diagnostic nanoparticles (NPs), or nanomedicines, have been formulated for improved drug delivery and imaging applications. Microfluidic technology enables continuous and highly reproducible synthesis of NPs through controlled mixing processes at the micro- and nanoscale. Yet, the inherent low-throughput remains a critical roadblock, precluding the probable applications of new nanomedicines for clinical translation. Here we present robust manufacturing of lipid-polymer NPs (LPNPs) through feedback controlled operation of parallelized swirling microvortex reactors (SMRs)...
July 20, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28726912/3d-material-cytometry-3dmac-a-very-high-replicate-high-throughput-analytical-method-using-microfabricated-shape-specific-cell-material-niches
#17
Kirsten Parratt, Jenny Jeong, Peng Qiu, Krishnendu Roy
Studying cell behavior within 3D material niches is key to understanding cell biology in health and diseases, and developing biomaterials for regenerative medicine applications. Current approaches to studying these cell-material niches have low throughput and can only analyze a few replicates per experiment resulting in reduced measurement assurance and analytical power. Here, we report 3D material cytometry (3DMaC), a novel high-throughput method based on microfabricated, shape-specific 3D cell-material niches and imaging cytometry...
July 20, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28726902/limiting-the-valence-advancements-and-new-perspectives-on-patchy-colloids-soft-functionalized-nanoparticles-and-biomolecules
#18
Emanuela Bianchi, Barbara Capone, Ivan Coluzza, Lorenzo Rovigatti, Peter D J van Oostrum
Limited bonding valence, usually accompanied by well-defined directional interactions and selective bonding mechanisms, is nowadays considered among the key ingredients to create complex structures with tailored properties: even though isotropically interacting units already guarantee access to a vast range of functional materials, anisotropic interactions can provide extra instructions to steer the assembly of specific architectures. The anisotropy of effective interactions gives rise to a wealth of self-assembled structures both in the realm of suitably synthesized nano- and micro-sized building blocks and in nature, where the isotropy of interactions is often a zero-th order description of the complicated reality...
July 20, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28726745/dual-source-linear-energy-prediction-line-p-model-in-the-context-of-wsns
#19
Faisal Ahmed, Gert Tamberg, Yannick Le Moullec, Paul Annus
Energy harvesting technologies such as miniature power solar panels and micro wind turbines are increasingly used to help power wireless sensor network nodes. However, a major drawback of energy harvesting is its varying and intermittent characteristic, which can negatively affect the quality of service. This calls for careful design and operation of the nodes, possibly by means of, e.g., dynamic duty cycling and/or dynamic frequency and voltage scaling. In this context, various energy prediction models have been proposed in the literature; however, they are typically compute-intensive or only suitable for a single type of energy source...
July 20, 2017: Sensors
https://www.readbyqxmd.com/read/28726714/performance-of-a-novel-recycling-magnetic-flocculation-membrane-filtration-process-for-tetracycline-polluted-surface-water-treatment
#20
Yufei Wang, Hui Jia, Hongwei Zhang, Jie Wang, Wenjin Liu
A recycling magnetic flocculation membrane filtration (RMFMF) process integrating circulating coagulation, magnetic enhanced flocculation and membrane filtration was investigated for the treatment of surface water micro-polluted by tetracycline, a typical pharmaceutical and personal care product. A bench-scale experiment was conducted and several water quality parameters including turbidity, ultraviolet absorbance at 254 nm (UV254), total organic carbon and tetracycline concentration were evaluated, taking coagulation membrane filtration and magnetic flocculation membrane filtration processes as reference treatments...
July 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
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