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https://www.readbyqxmd.com/read/27913657/cost-benefit-analysis-of-telehealth-in-pre-hospital-care
#1
James R Langabeer, Tiffany Champagne-Langabeer, Diaa Alqusairi, Junghyun Kim, Adria Jackson, David Persse, Michael Gonzalez
OBJECTIVE: There has been very little use of telehealth in pre-hospital emergency medical services (EMS), yet the potential exists for this technology to transform the current delivery model. In this study, we explore the costs and benefits of one large telehealth EMS initiative. METHODS: Using a case-control study design and both micro- and gross-costing data from the Houston Fire Department EMS electronic patient care record system, we conducted a cost-benefit analysis (CBA) comparing costs with potential savings associated with patients treated through a telehealth-enabled intervention...
December 2, 2016: Journal of Telemedicine and Telecare
https://www.readbyqxmd.com/read/27913355/hierarchically-micro-and-nanopatterned-topographical-cues-for-modulation-of-cellular-structure-and-function
#2
Hoon Seonwoo, Won-Gyu Bae, Sunho Park, Hong-Nam Kim, Kyoung Soon Choi, Ki Taek Lim, Hoon Hyun, Jin-Woo Kim, Jangho Kim, Jong Hoon Chung
Living cells receive biochemical and physical information from the surrounding microenvironment and respond to this information. Multiscale hierarchical substrates with micro- and nanogrooves have been shown to mimic the native extracellular matrix (ECM) better than conventional nanopatterned substrates; therefore, substrates with hierarchical topographical cues are considered suitable for investigating the role of physical factors in tissue functions. In this study, precisely controllable, multiscale hierarchical substrates that could mimic the micro- and nanotopography of complex ECMs were fabricated and used to culture various cell types, including fibroblasts, endothelial cells, osteoblasts, and human mesenchymal stem cells...
December 1, 2016: IEEE Transactions on Nanobioscience
https://www.readbyqxmd.com/read/27913249/comparison-of-the-transcriptomic-profile-of-hepatic-human-induced-pluripotent-stem-like-cells-cultured-in-plates-and-in-a-3d-microscale-dynamic-environment
#3
Eric Leclerc, Keiichi Kimura, Marie Shinohara, Mathieu Danoy, Morgane Le Gall, Taketomo Kido, Atsushi Miyajima, Teruo Fujii, Yasuyuki Sakai
We have compared the transcriptomic profiles of human induced pluripotent stem cells after their differentiation in hepatocytes like cells in plates and microfluidic biochips. The biochips provided a 3D and dynamic support during the cell differentiation when compared to the 2D static cultures in plates. The microarray have demonstrated the up regulation of important pathway related to liver development and maturation during the culture in biochips. Furthermore, the results of the transcriptomic profile, coupled with immunostaining, and RTqPCR analysis have shown typical biomarkers illustrating the presence of responders of biliary like cells, hepatocytes like cells, and endothelial like cells...
November 29, 2016: Genomics
https://www.readbyqxmd.com/read/27913178/estimating-the-material-properties-of-heel-pad-sub-layers-using-inverse-finite-element-analysis
#4
Nafiseh Ahanchian, Christopher J Nester, David Howard, Lei Ren, Daniel Parker
Detailed information about the biomechanical behaviour of plantar heel pad tissue contributes to our understanding of load transfer when the foot impacts the ground. The objective of this work was to obtain the hyperelastic and viscoelastic material properties of heel pad sub-layers (skin, micro-chamber and macro-chamber layers) in-vivo. An anatomically detailed 3D Finite Element model of the human heel was used to derive the sub-layer material properties. A combined ultrasound imaging and motorised platform system was used to compress heel pad and to create input data for the Finite Element model...
November 29, 2016: Medical Engineering & Physics
https://www.readbyqxmd.com/read/27913008/microrna-98-plays-a-critical-role-in-experimental-myocarditis
#5
Xiao Chen, Shuo Dong, Ningning Zhang, Liang Chen, Mao-Gang Li, Ping-Chang Yang, Jiangping Song
BACKGROUND AND AIMS: Myocarditis is inflammation in the heart; its pathogenesis is to be further investigated. Activities of micro RNAs (miR) are associated with immune inflammation. This study tests a hypothesis that miR-98 is involved in the development of myocarditis. METHODS: BALB/c mice were immunized with cardiac α-myosin heavy chain peptides (MyHC-α) to induce myocarditis. The effects of miR-98 on regulation of interleukin (IL)-10 were assessed by real time RT-PCR...
November 23, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27912973/micro-ureteroscopy-for-the-treatment-of-distal-ureteral-calculi-in-children
#6
Mehmet Mazhar Utanğaç, Ahmet Ali Sancaktutar, Abdulkadir Tepeler
OBJECTIVE: The objective of this study was to demonstrate the efficacy and safety of micro-ureteroscopy (micro-URS) in the management of distal ureteral stones in the pediatric population. MATERIALS AND METHODS: A total of 11 children, who had undergone micro-URS between September 2015 and April 2016 with the indication of distal ureteral calculi in two referral centers, were retrospectively evaluated. The procedures were performed with the patient in the lithotomy position under general anesthesia using the standard URS technique with a micro-ureteroscope that has a caliber of 4...
November 17, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27912140/characterization-of-the-cleaved-edge-cross-section-of-the-heterostructures-with-gamnas-layer-by-the-confocal-micro-raman-spectroscopy
#7
A V Kudrin, S M Plankina, O V Vikhrova, A V Nezhdanov, A I Mashin, Yu N Drozdov, A V Shvetsov
Confocal micro-Raman spectroscopy was used to measure cross-section linescans of the cleaved edge of heterostructures involving a GaMnAs layer. The investigations revealed a shift of the TO mode in the compressed GaMnAs layer to high frequencies relative to the TO GaAs mode in the substrate and to low frequencies in the tensile GaMnAs layers. These results are in agreement with the different manifestations of the anomalous Hall effect in the GaMnAs layers, with either compressive or tensile strains. It is shown that Raman spectroscopy is an appropriate method for the investigation of cross-sectional semiconductor heterostructures whose total thickness is comparable to the size of the analyzing laser spot...
November 21, 2016: Micron: the International Research and Review Journal for Microscopy
https://www.readbyqxmd.com/read/27912032/pain-input-impairs-recovery-after-spinal-cord-injury-treatment-with-lidocaine
#8
Joel D Turtle, Misty M Strain, Miriam Aceves, Yung-Jen Huang, Joshua A Reynolds, Michelle A Hook, James W Grau
More than 90% of spinal cord injuries are caused by traumatic accidents and are often associated with other tissue damage (polytrauma) that can provide a source of continued pain input during recovery. In a clinically relevant spinal cord contusion injury model, prior work has shown that noxious stimulation at an intensity that engages pain (C) fibers soon after injury augments secondary injury and impairs functional recovery. Noxious input increases the expression of pro-inflammatory cytokines (interleukin 1β and 18), cellular signals associated with cell death (caspase 3 and 8), and physiological signs of hemorrhage...
December 2, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27911397/nanostructured-ag-zeolite-composites-as-luminescence-based-humidity-sensors
#9
Eduardo Coutino-Gonzalez, Wouter Baekelant, Bjorn Dieu, Maarten B J Roeffaers, Johan Hofkens
Small silver clusters confined inside zeolite matrices have recently emerged as a novel type of highly luminescent materials. Their emission has high external quantum efficiencies (EQE) and spans the whole visible spectrum. It has been recently reported that the UV excited luminescence of partially Li-exchanged sodium Linde type A zeolites [LTA(Na)] containing luminescent silver clusters can be controlled by adjusting the water content of the zeolite. These samples showed a dynamic change in their emission color from blue to green and yellow upon an increase of the hydration level of the zeolite, showing the great potential that these materials can have as luminescence-based humidity sensors at the macro and micro scale...
November 15, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27911352/medical-equipment-antiseptic-processes-using-the-atmospheric-plasma-sprayed-copper-coatings
#10
M Goudarzi, Sh Saviz, M Ghoranneviss, A Salar Elahi
Antibacterial surfaces such as copper coatings are able to reduce the growth of bacteria. In this study, copper coatings was deposited on the 316 stainless steel substrates by a handmade device operating as an atmospheric plasma spraying system. The chemical composition microstructure and morphology surface of the coatings are examined by x-ray diffraction (XRD) and scanning electron microscope (SEM) and back scattering electron microscope (BSE). Micro hardness as one of the key properties of the coating is characterized based on cross-section...
November 30, 2016: Journal of X-ray Science and Technology
https://www.readbyqxmd.com/read/27911257/individualized-antibiotic-therapy-in-patients-with-ventilator-associated-pneumonia
#11
Gurdal Yilmaz, Sedat Saylan, Firdevs Aksoy, Iftihar Koksal
The optimal duration of treatment of ventilator-associated pneumonia (VAP) is still the subject of debate. While 1-week treatment has been reported as possibly sufficient, patients generally receive antibiotic therapy for 10-14 days. The purpose of our study was to investigate whether length of treatment in patients with VAP can be reduced with an individualized therapeutic strategy. The study was performed prospectively with patients diagnosed with VAP in our hospital's intensive care units between 1 January and 31 December, 2015...
December 1, 2016: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/27911087/%C3%AE-amyrin-attenuates-high-fructose-diet-induced-metabolic-syndrome-in-rats
#12
Pankaj Prabhakar, K H Reeta, Subir Kumar Maulik, Amit Kumar Dinda, Yogendra Kumar Gupta
This study investigated the effect of α-amyrin (a pentacyclic triterpene) on high-fructose diet (HFD)-induced metabolic syndrome in rats. Male Wistar rats were randomly distributed into different groups. The control group was fed normal rat chow diet. The HFD group was fed HFD (60%; w/w) for 42 days. Pioglitazone (10 mg/kg, orally, once daily) was used as a standard drug. α-Amyrin was administered in 3 doses (50, 100, and 200 mg/kg, orally, once daily along with HFD). Plasma glucose, total cholesterol, triglycerides, and high-density lipoprotein cholesterol (HDL-C) were estimated...
September 2, 2016: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/27910988/visible-light-controlled-catalytic-cu2o-au-micromotors
#13
Dekai Zhou, Yuguang C Li, Pengtao Xu, Nicholas S McCool, Longqiu Li, Wei Wang, Thomas E Mallouk
Visible light driven Cu2O-Au micromotors exhibit rapid on/off switching and speed control. Electrochemical measurements confirm that the light-induced movement of the Cu2O-Au micromotors involves a self-electrophoresis mechanism modulated by the photoconductivity of Cu2O. This study extends the utilization of the electromagnetic spectrum for micro/nanomotors into the visible range.
December 2, 2016: Nanoscale
https://www.readbyqxmd.com/read/27910852/kaleidoscopic-imaging-patterns-of-complex-structures-fabricated-by-laser-induced-deformation
#14
Haoran Zhang, Fengyou Yang, Jianjie Dong, Lena Du, Chuang Wang, Jianming Zhang, Chuan Fei Guo, Qian Liu
Complex surface structures have stimulated a great deal of interests due to many potential applications in surface devices. However, in the fabrication of complex surface micro-/nanostructures, there are always great challenges in precise design, or good controllability, or low cost, or high throughput. Here, we present a route for the accurate design and highly controllable fabrication of surface quasi-three-dimensional (quasi-3D) structures based on a thermal deformation of simple two-dimensional laser-induced patterns...
December 2, 2016: Nature Communications
https://www.readbyqxmd.com/read/27910818/histomorphometric-and-transcriptome-evaluation-of-early-healing-bone-treated-with-a-novel-human-particulate-dentin-powder
#15
Yu-Chih Huang, Wei-Zhen Lew, Sheng-Wei Feng, Wei-Yi Lai, Yoshimitsu Abiko, Haw-Ming Huang
Human particulate dentin (HPD) shows potential as an alternative bone grafting material. However, the mechanism of bone healing at the molecular level after grafting with HPD is unclear. This study assessed the histological and global gene expression of bone tissues grafted with HPD. The HPD was prepared to 250-500 µm in size. X-ray diffraction (XRD) and energy dispersive x-ray spectroscopy (EDX) were performed to confirm the crystal structure, organic compound residues, and surface morphology, respectively...
December 2, 2016: Biomedical Materials
https://www.readbyqxmd.com/read/27910624/a-scanning-hall-probe-microscope-for-high-resolution-large-area-variable-height-magnetic-field-imaging
#16
Gorky Shaw, R B G Kramer, N M Dempsey, K Hasselbach
We present a scanning Hall probe microscope operating in ambient conditions. One of the unique features of this microscope is the use of the same stepper motors for both sample positioning as well as scanning, which makes it possible to have a large scan range (few mm) in the x and y directions, with a scan resolution of 0.1 μm. Protocols have been implemented to enable scanning at different heights from the sample surface. The z range is 35 mm. Microstructured Hall probes of size 1-5 μm have been developed...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910531/a-micro-scale-plasma-spectrometer-for-space-and-plasma-edge-applications-invited
#17
E E Scime, A M Keesee, M Dugas, S Ellison, J Tersteeg, G Wagner, A Barrie, A Rager, D Elliott
A plasma spectrometer design based on advances in lithography and microchip stacking technologies is described. A series of curved plate energy analyzers, with an integrated collimator, is etched into a silicon wafer. Tests of spectrometer elements, the energy analyzer and collimator, were performed with a 5 keV electron beam. The measured collimator transmission and energy selectivity were in good agreement with design targets. A single wafer element could be used as a plasma processing or fusion first wall diagnostic...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910513/spatial-resolution-of-a-spherical-x-ray-crystal-spectrometer-at-various-magnifications
#18
Lan Gao, K W Hill, M Bitter, P C Efthimion, L Delgado-Aparicio, N A Pablant, E O Baronova, N R Pereira
A high spatial resolution of a few μm is often required for probing small-scale high-energy-density plasmas using high resolution x-ray imaging spectroscopy. This resolution can be achieved by adjusting system magnification to overcome the inherent limitation of the detector pixel size. Laboratory experiments on investigating the relation between spatial resolution and system magnification for a spherical crystal spectrometer are presented. Tungsten Lβ2 rays from a tungsten-target micro-focus x-ray tube were diffracted by a Ge 440 crystal, which was spherically bent to a radius of 223 mm, and imaged onto an x-ray CCD with 13-μm pixel size...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910503/characterization-of-x-ray-framing-cameras-for-the-national-ignition-facility-using-single-photon-pulse-height-analysis
#19
J P Holder, L R Benedetti, D K Bradley
Single hit pulse height analysis is applied to National Ignition Facility x-ray framing cameras to quantify gain and gain variation in a single micro-channel plate-based instrument. This method allows the separation of gain from detectability in these photon-detecting devices. While pulse heights measured by standard-DC calibration methods follow the expected exponential distribution at the limit of a compound-Poisson process, gain-gated pulse heights follow a more complex distribution that may be approximated as a weighted sum of a few exponentials...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910450/first-order-reversal-curves-forc-analysis-of-individual-magnetic-nanostructures-using-micro-hall-magnetometry
#20
Merlin Pohlit, Paul Eibisch, Maryam Akbari, Fabrizio Porrati, Michael Huth, Jens Müller
Alongside the development of artificially created magnetic nanostructures, micro-Hall magnetometry has proven to be a versatile tool to obtain high-resolution hysteresis loop data and access dynamical properties. Here we explore the application of First Order Reversal Curves (FORC)-a technique well-established in the field of paleomagnetism for studying grain-size and interaction effects in magnetic rocks-to individual and dipolar-coupled arrays of magnetic nanostructures using micro-Hall sensors. A proof-of-principle experiment performed on a macroscopic piece of a floppy disk as a reference sample well known in the literature demonstrates that the FORC diagrams obtained by magnetic stray field measurements using home-built magnetometers are in good agreement with magnetization data obtained by a commercial vibrating sample magnetometer...
November 2016: Review of Scientific Instruments
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