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https://www.readbyqxmd.com/read/28927136/low-risk-population-among-patients-with-tumor-node-metastasis-stage-iii-iv-oral-squamous-cell-carcinoma
#1
Tohru Ikeda, Sachiko Seki, Mutsunori Fujiwara, Masaaki Matsuura, Yuu Ozaki-Honda, Shuichi Fujita, Hisazumi Ikeda, Masahiro Umeda, Izumi Asahina
A novel system auxiliary to the Union for International Cancer Control classification may allow the prognosis of patients with malignant tumors at similar stages to be predicted, as currently this is challenging. The present study generated a novel system to predict populations at low risk among patients with stage III/IV oral squamous cell carcinoma (OSCC). A total of 41 patients who were diagnosed at stages III/IV OSCC and underwent surgical tumor resection were analyzed. Band-like or follicular lymphocyte infiltration, intraepithelial micro-abscess formation and natural killer (NK) cell infiltration were histopathologically evaluated...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28927077/associations-between-the-expression-of-mta1-and-vegf-c-in-esophageal-squamous-cell-carcinoma-with-lymph-angiogenesis-and-lymph-node-metastasis
#2
Jianping Liu, Juan Xia, Yongheng Zhang, Maoyong Fu, Sheng Gong, Yulong Guo
The aim of the present study was to investigate the association between the expression levels of metastasis-related gene 1 (MTA1) and vascular endothelial growth factor C (VEGF-C) in esophageal squamous cell carcinoma (ESCC) with lymph angiogenesis and lymph node metastasis. The paraffin-embedded tissue samples of 107 cases of ESCC and 56 cases of normal esophageal tissues were collected from the Department of Cardiothoracic Surgery, Suining Central Hospital from March 2013 to January 2014. Immunohistochemical assays were performed to detect the expression levels of MTA1, VEGF-C and D2-40 in ESCC, and the micro-lymphatic vessel density (LVD) was evaluated...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28926787/a-novel-a-b-process-for-enhanced-biological-nutrient-removal-in-municipal-wastewater-reclamation
#3
Guangjing Xu, Han Wang, Jun Gu, Nan Shen, Zheng Qiu, Yan Zhou, Yu Liu
This study developed an innovative A-B process for enhanced nutrients removal in municipal wastewater reclamation, in which a micro-aerated moving bed biofilm reactor served as A-stage and a step-feed sequencing batch reactor (SBR) as B-stage. In the A-stage, 55% of COD and 15% of ammonia nitrogen was removed, while more than 88% of the total nitrogen was removed via nitritation and denitritation, together with 93% of phosphorous removal at the B-stage where ammonia oxidizing bacteria activity was significantly higher than nitrite oxidizing bacteria activity...
September 12, 2017: Chemosphere
https://www.readbyqxmd.com/read/28926707/medieval-gilding-technology-of-historical-metal-threads-revealed-by-electron-optical-and-micro-raman-spectroscopic-study-of-focused-ion-beam-milled-cross-sections
#4
Tamás Gábor Weiszburg, Katalin Gherdán, Kitti Ratter, Norbert Zajzon, Zsolt Bendő, György Z Radnoczi, Ágnes Takács, Tamás Váczi, Gábor Varga, György Szakmány
Although gilt silver threads were widely used for decorating historical textiles, their manufacturing techniques have been elusive for centuries. Contemporary written sources give only limited, sometimes ambiguous information, and detailed cross-sectional study of the microscale soft noble metal objects has been hindered by sample preparation. In this work, to give a thorough characterization of historical gilt silver threads, nano- and microscale textural, chemical and structural data on cross sections, prepared by focused ion beam milling, were collected, using various electron-optical methods (high-resolution scanning electron microscopy (SEM), wavelength-dispersive electron probe microanalysis (EPMA), electron back-scattered diffraction (EBSD) combined with energy-dispersive electron probe microanalysis (EDX), transmission electron microscopy (TEM) combined with EDX, and micro-Raman spectroscopy...
September 19, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28926512/orthosiphon-stamineus-misai-kucing-ameliorated-postmenopausal-osteoporosis-in-rat-model
#5
Rubiatul Adawiyah Bokhari, Seng Fong Lau, Suhaila Mohamed
OBJECTIVE: Orthosiphon stamineus (OS) or Misai Kucing (Java tea) is a popular herbal supplement from Southeast Asia for various metabolic, age-related diseases. This study investigated the potential use of OS leaf extracts to ameliorate osteoporosis in ovariectomized rats. METHODS: Fifty-six female Sprague-Dawley rats were randomly allocated into eight groups (n = 7): SHAM (healthy sham control); OVX (ovarietomized) nontreated rats (negative control); OVX + Remifemin (100 mg/kg body weight), and 2% green tea extract (positive controls); OVX + OS 50% ethanolic and aqueous extracts, both at either 150 or 300 mg/kg...
September 18, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28926221/fourier-transform-ms-and-closed-path-multi-reflection-time-of-flight-ms-using-an-electrostatic-linear-ion-trap
#6
Eric T Dziekonski, Joshua T Johnson, Kenneth W Lee, Scott A McLuckey
An electrostatic linear ion trap (ELIT) has been configured to allow for the simultaneous acquisition of mass spectra via Fourier transform (FT) techniques (frequency measurement) and via time-of-flight (TOF) (time measurement). In the former case, the time-domain image charge derived from a pick-up electrode in the field-free region of the ELIT is converted to frequency-domain data via Fourier transformation (i.e., FT-ELIT MS). In the latter case, the time difference between ion injection into the ELIT and ion detection after release from the ELIT using a micro-channel plate (MCP) enables the acquisition of multi-reflection time-of-flight mass spectra (MR-TOF MS)...
September 19, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28926100/electrokinetic-motion-of-a-spherical-micro-particle-at-an-oil-water-interface-in-microchannel
#7
Chengfa Wang, Mengqi Li, Yongxin Song, Xinxiang Pan, Dongqing Li
The electrokinetic motion of a negatively charged spherical particle at an oil-water interface in a microchannel is numerically investigated and analyzed in this paper. A three-dimensional (3D) transient numerical model is developed to simulate the particle electrokinetic motion. The channel wall, the surface of the particle and the oil-water interface are all considered negatively charged. The effects of the direct current (DC) electric field, the zeta potentials of the particle-water interface and the oil-water interface, and the dynamic viscosity ratio of oil to water on the velocity of the particle are studied in this paper...
September 19, 2017: Electrophoresis
https://www.readbyqxmd.com/read/28926099/anti-osteoporosis-activity-of-sanguinarine-in-preosteoblast-mc3t3-e1-cells-and-an-ovariectomized-rat-model
#8
Fuzhan Zhang, Jile Xie, Genlin Wang, Ge Zhang, Huilin Yang
Sanguinarine, a benzophenanthridine alkaloid, has been previously demonstrated to exert antimicrobial, anti-inflammatory and anti-tumor activities. A previous study has identified Sanguinarine as a potential drug candidate for osteoporosis treatment by computational bioinformatics analysis. This study further evaluated the effects of Sanguinarine on the differentiation of murine preosteoblast MC3T3-E1 cells and its anti-osteoporosis activity in an ovarietomized rat model. Sanguinarine treatment (0.25, 0.5, 1 and 2 µM) of MC3T3-E1 cells significantly increased alkaline phosphatase (ALP) activity and the phoshporalyation of AMP-activated protein kinase α subunit (AMPKα), but did not affect cell proliferation...
September 19, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28925991/a-multiscale-imaging-and-modelling-dataset-of-the-human-inner-ear
#9
Nicolas Gerber, Mauricio Reyes, Livia Barazzetti, Hans Martin Kjer, Sergio Vera, Martin Stauber, Pavel Mistrik, Mario Ceresa, Nerea Mangado, Wilhelm Wimmer, Thomas Stark, Rasmus R Paulsen, Stefan Weber, Marco Caversaccio, Miguel A González Ballester
Understanding the human inner ear anatomy and its internal structures is paramount to advance hearing implant technology. While the emergence of imaging devices allowed researchers to improve understanding of intracochlear structures, the difficulties to collect appropriate data has resulted in studies conducted with few samples. To assist the cochlear research community, a large collection of human temporal bone images is being made available. This data descriptor, therefore, describes a rich set of image volumes acquired using cone beam computed tomography and micro-CT modalities, accompanied by manual delineations of the cochlea and sub-compartments, a statistical shape model encoding its anatomical variability, and data for electrode insertion and electrical simulations...
September 19, 2017: Scientific Data
https://www.readbyqxmd.com/read/28925681/enhanced-coalescence-induced-droplet-jumping-on-nanostructured-superhydrophobic-surfaces-in-the-absence-of-microstructures
#10
Peng Zhang, Yota Maeda, Fengyong Lv, Yasuyuki Takata, Daniel Orejon
Superhydrophobic surfaces are receiving increasing attention due to the enhanced condensation heat transfer, self-cleaning and anti-icing properties by easing droplet self-removal. Despite the extensive research carried out in this topic, the presence or absence of microstructures on droplet adhesion during condensation has not been addressed yet. In this work we, therefore, address the condensation behavior on engineered superhydrophobic copper oxide surfaces with different structural finishes. More specifically, we investigate the coalescence-induced droplet-jumping performance on superhydrophobic surfaces with structures varying from the micro- to the nano-scale...
September 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28925581/advanced-materials-based-on-polymers-and-ionic-liquids
#11
REVIEW
Yuzo Kitazawa, Kazuhide Ueno, Masayoshi Watanabe
Ionic liquids (ILs) are ambient temperature molten salts, which have attracted considerable attention owing to their unique properties. In this contribution, we review advanced materials composed of ILs and polymers for the basis of a new design protocol to fabricate novel materials. As electrolytes for electrochemical devices, cross-linked polymers containing ILs (ion gels) are endowed with functional properties inherited from ILs and mechanical consistency derived from polymers. To create such materials, micro-phase separation of block copolymers and colloidal arrays in the ILs are utilized...
September 19, 2017: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/28925491/corrosion-behavior-of-dental-implants-immersed-into-human-saliva-preliminary-results-of-an-in-vitro-study
#12
M Barbieri, F Mencio, P Papi, D Rosella, S Di Carlo, T Valente, G Pompa
OBJECTIVE: Over the years, different implant surfaces have been used to try to maximize bone to implant contact. The aim of this study was to compare levels of metallic ions and particles dissolution collected from two different dental implants surfaces immersed into human saliva. PATIENTS AND METHODS: A total of 60 dental implants were tested. Group A: sanded with aluminium oxide medium grade particles and acid-etched; Group B: micro-sanded with calcium phosphate powders and acid-etched...
August 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28925399/dock4-promotes-loss-of-proliferation-in-glioblastoma-progenitor-cells-through-nuclear-beta-catenin-accumulation-and-subsequent-mir-302-367-cluster-expression
#13
D N Debruyne, L Turchi, F Burel-Vandenbos, M Fareh, F Almairac, V Virolle, D Figarella-Branger, N Baeza-Kallee, P Lagadec, V Kubiniek, P Paquis, D Fontaine, M-P Junier, H Chneiweiss, T Virolle
Glioblastomas (GBM) are lethal primitive brain tumours characterized by a strong intra-tumour heterogeneity. We observed in GBM tissues the coexistence of functionally divergent micro-territories either enriched in more differentiated and non-mitotic cells or in mitotic undifferentiated OLIG2 positive cells while sharing similar genomic abnormalities. Understanding the formation of such functionally divergent micro-territories in glioblastomas (GBM) is essential to comprehend GBM biogenesis, plasticity and to develop therapies...
September 18, 2017: Oncogene
https://www.readbyqxmd.com/read/28925149/-research-on-modeling-method-to-analyze-lonicerae-japonicae-flos-extraction-process-with-online-mems-nir-based-on-two-types-of-error-detection-theory
#14
Chen-Zhao Du, Zhi-Sheng Wu, Na Zhao, Zheng Zhou, Xin-Yuan Shi, Yan-Jiang Qiao
To establish a rapid quantitative analysis method for online monitoring of chlorogenic acid in aqueous solution of Lonicera Japonica Flos extraction by using micro-electromechanical near infrared spectroscopy (MEMS-NIR). High performance liquid chromatography(HPLC) was used as reference method.Kennard-Stone (K-S) algorithm was used to divide sample sets, and partial least square(PLS) regression was adopted to establish the multivariate analysis model between the HPLC analysis contents and NIR spectra. The synergy interval partial least squares (SiPLS) was used to selected modeling waveband to establish PLS models...
October 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28925020/one-pot-synthesis-of-size-controllable-core-shell-cds-and-derivative-cds-znxcd1-xs-structures-for-dramatic-photocatalytic-hydrogen-production
#15
Shuangshuang Kai, Baojuan Xi, Yifeng Wang, Shenglin Xiong
Chalcogenide micro/nano composite structures have been attracting world-wide attention due to the enormous prospect of applications in photocatalytic hydrogen production. Well-defined micro/nanostructures, featured with predominant properties, are of extraordinary importance. Herein, we reported a facile one-pot method on synthesis of monodispersed size-controllable CdS and CdS@ZnxCd1-xS core-shell submicrospheres, which were engineered with respect to the structural conformation and size. CdS core-shell submicrospheres with different size were selectively prepared for the first time...
September 18, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28924384/fgfr3-deficient-mice-have-accelerated-fracture-repair
#16
Yangli Xie, Fengtao Luo, Wei Xu, Zuqiang Wang, Xianding Sun, Meng Xu, Junlan Huang, Dali Zhang, Qiaoyan Tan, Bo Chen, Wanling Jiang, Xiaolan Du, Lin Chen
Bone fracture healing is processed through multiple biological stages that partly recapitulates the skeletal development process. FGFR3 is a negative regulator of chondrogenesis during embryonic stage and plays an important role in both chondrogenesis and osteogenesis. We have investigated the role of FGFR3 in fracture healing using unstabilized fracture model and found that gain-of-function mutation of FGFR3 inhibits the initiation of chondrogenesis during cartilage callus formation. Here, we created closed, stabilized proximal tibia fractures with an intramedullary pin in Fgfr3(-/-)mice and their littermate wild-type mice...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/28924381/osthole-promotes-bone-fracture-healing-through-activation-of-bmp-signaling-in-chondrocytes
#17
Pinger Wang, Jun Ying, Cheng Luo, Xing Jin, Shanxing Zhang, Taotao Xu, Lei Zhang, Meng Mi, Di Chen, Peijian Tong, Hongting Jin
Osthole is a bioactive coumarin derivative and has been reported to be able to enhance bone formation and improve fracture healing. However, the molecular mechanism of Osthole in bone fracture healing has not been fully defined. In this study we determined if Osthole enhances bone fracture healing through activation of BMP2 signaling in mice. We performed unilateral open transverse tibial fracture procedure in 10-week-old C57BL/6 mice which were treated with or without Osthole. Our previous studies demonstrated that chondrocyte BMP signaling is required for bone fracture healing, in this study we also performed tibial fracture procedure in Cre-negative and Col2-Cre;Bmp2(flox/flox) conditional knockout (KO) mice (Bmp2(Col2Cre) ) to determine if Osthole enhances fracture healing in a BMP2-dependent manner...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/28924172/multi-characterization-of-licoo2-cathode-films-using-advanced-afm-based-techniques-with-high-resolution
#18
Jiaxiong Wu, Shan Yang, Wei Cai, Zhuanfang Bi, Guangyi Shang, Junen Yao
The thin film Li-ion batteries have been extensively used in micro-electronic devices due to their miniaturization, high capacity density and environmental friendliness, etc. In order to further prolong the lifetime of the film batteries, one of important tasks is to explore the aging mechanisms of the cathode films. In this paper, we especially focused on the multi-characterization of the LiCoO2 film in nanoscale, which is carried out by combining advanced AFM-based techniques with capacity measurement. The surface morphology, contact stiffness as well as surface potential were measured by amplitude modulation-frequency modulation (AM-FM) and kelvin probe force microscope (KPFM), respectively...
September 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28924159/live-bearing-without-placenta-physical-estimation-indicates-the-high-oxygen-supplying-ability-of-white-shark-uterus-to-the-embryo
#19
Taketeru Tomita, Ryo Nozu, Masaru Nakamura, Shohei Matsuzaki, Kei Miyamoto, Keiichi Sato
One of the mysteries of shark aplacental viviparity is the ability of the embryos to acquire oxygen from their mothers without a placental connection. It has been assumed that embryonic respiration in aplacental viviparous shark depends on oxygen from the uterine wall, although this hypothesis has not been confirmed quantitatively. Morphological observations of the uterine wall of white shark (Carcharodon carcharias) provided the first quantitative evidence to support the ability of the uterus to supply ample oxygen to the embryo of viviparous elasmobranchs...
September 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28923936/isolation-of-exosomes-from-whole-blood-by-integrating-acoustics-and-microfluidics
#20
Mengxi Wu, Yingshi Ouyang, Zeyu Wang, Rui Zhang, Po-Hsun Huang, Chuyi Chen, Hui Li, Peng Li, David Quinn, Ming Dao, Subra Suresh, Yoel Sadovsky, Tony Jun Huang
Exosomes are nanoscale extracellular vesicles that play an important role in many biological processes, including intercellular communications, antigen presentation, and the transport of proteins, RNA, and other molecules. Recently there has been significant interest in exosome-related fundamental research, seeking new exosome-based biomarkers for health monitoring and disease diagnoses. Here, we report a separation method based on acoustofluidics (i.e., the integration of acoustics and microfluidics) to isolate exosomes directly from whole blood in a label-free and contact-free manner...
September 18, 2017: Proceedings of the National Academy of Sciences of the United States of America
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