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https://www.readbyqxmd.com/read/28351016/nano-enabled-paper-humidity-sensor-for-mobile-based-point-of-care-lung-function-monitoring
#1
Mitradip Bhattacharjee, Harshal B Nemade, Dipankar Bandyopadhyay
The frequency of breathing and peak flow rate of exhaled air are necessary parameters to detect chronic obstructive pulmonary diseases (COPDs) such as asthma, bronchitis, or pneumonia. We developed a lung function monitoring point-of-care-testing device (LFM-POCT) consisting of mouthpiece, paper-based humidity sensor, micro-heater, and real-time monitoring unit. Fabrication of a mouthpiece of optimal length ensured that the exhaled air was focused on the humidity-sensor. The resistive relative humidity sensor was developed using a filter paper coated with nanoparticles, which could easily follow the frequency and peak flow rate of the human breathing...
March 22, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28350850/defective-bone-repair-in-mast-cell-deficient-cpa3cre-mice
#2
Jose Luis Ramirez-GarciaLuna, Daniel Chan, Robert Samberg, Mira Abou-Rjeili, Timothy H Wong, Ailian Li, Thorsten B Feyerabend, Hans-Reimer Rodewald, Janet E Henderson, Paul A Martineau
In the adult skeleton, cells of the immune system interact with those of the skeleton during all phases of bone repair to influence the outcome. Mast cells are immune cells best known for their pathologic role in allergy, and may be involved in chronic inflammatory and fibrotic disorders. Potential roles for mast cells in tissue homeostasis, vascularization and repair remain enigmatic. Previous studies in combined mast cell- and Kit-deficient KitW-sh/W-sh mice (KitW-sh) implicated mast cells in bone repair but KitW-sh mice suffer from additional Kit-dependent hematopoietic and non- hematopoietic deficiencies that could have confounded the outcome...
2017: PloS One
https://www.readbyqxmd.com/read/28350671/enhanced-calvarial-bone-healing-in-cd11c-tlr4-and-myd88-mice
#3
Dan Wang, Gwen M Taylor, James R Gilbert, Joseph E Losee, Chhinder P Sodhi, David J Hackam, Timothy R Billiar, Gregory M Cooper
BACKGROUND: Inflammation is integral to the injury response. The inflammatory response is essential to the host defense against infection and also to tissue regeneration and repair. Toll-like receptors (TLRs) are critical activators of the innate immune response and present attractive therapeutic targets for inflammation-modulated tissue regeneration. The authors' previous study showed that depletion of TLR4 resulted in accelerated skull bone healing concurrent with increased expression of osteoclastogenic genes...
April 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28350523/comparison-of-micro-ct-and-cone-beam-ct-on-the-feasibility-of-assessing-mandibular-trabecular-structures-in-mandibular-condyle
#4
Xin Liang, Zuyan Zhang, Jianping Gu, Zhihui Wang, Bart Vandenberghe, Reinhilde Jacobs, Jie Yang, Guowu Ma, Haibin Ling, Xuchen Ma
OBJECTIVES: To evaluate the accuracy of Cone-beam CT (CBCT) in assessing trabecular structures Methods: Two human mandibles were scanned by micro-CT (Skyscan 1173 high energy spiral scan micro-CT, Skyscan NV, Kontich, Belgium) and CBCT(3D Accuitomo 170, Morita Japan). The CBCT images were reconstructed in 0.5mm and 1 mm thickness. The condylar images were selected for registration. A parallel algorithm for histogram computation was introduced to perform the registration. Mutual information (MI) value was used to evaluate the match between the images obtained from micro-CT and CBCT...
March 28, 2017: Dento Maxillo Facial Radiology
https://www.readbyqxmd.com/read/28350455/model-based-classification-for-digital-pcr-your-umbrella-for-rain
#5
Bart K M Jacobs, Els Goetghebeur, Jo Vandesompele, Ariane De Ganck, Nele Nijs, Anneleen Beckers, Nina Papazova, Nancy Hélène C J Roosens, Lieven Clement
Standard data analysis pipelines for digital PCR estimate the concentration of a target nucleic acid by digitizing the end-point fluorescence of the parallel micro-PCR reactions using an automated hard threshold. While it is known that misclassification has a major impact on the concentration estimate and substantially reduces accuracy, the uncertainty of this classification is typically ignored. We introduce a model-based clustering method to estimate the probability that the target is present (absent) in a partition conditional on its observed fluorescence and the distributional shape in no template control samples...
March 28, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28350448/mechanism-exploration-of-ion-transport-in-nanocomposite-cation-exchange-membranes
#6
Xin Tong, Bopeng Zhang, Yilin Fan, Yongsheng Chen
The origin of property enhancement of nanocomposite ion exchange membranes (IEMs) is far from being fully understood. By combining experimental work and computational modeling analysis, we could determine the influence of nanomaterials on the ion transport properties of nanocomposite cation exchange membranes (CEMs). We synthesized and characterized a series of nanocomposite CEMs by using SPPO as polymer materials and silica nanoparticles (NPs) (unsulfonated or sulfonated) as nanomaterials. We found that with the increase of NP loading, measured CEM permselectivity and swelling degree first increased and then decreased...
March 28, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28350433/scalable-fabrication-of-photochemically-reduced-graphene-based-monolithic-micro-supercapacitors-with-superior-energy-and-power-densities
#7
Sen Wang, Zhong-Shuai Wu, Shuanghao Zheng, Feng Zhou, Chenglin Sun, Hui-Ming Cheng, Xinhe Bao
Micro-supercapacitors (MSCs) hold great promise as highly competitive miniaturized power sources satisfying the increased demand of smart integrated electronics. However, single-step scalable fabrication of MSCs with both high energy and power densities is still challenging. Here we demonstrate the scalable fabrication of graphene-based monolithic MSCs with diverse planar geometries and capable of superior integration by photochemical reduction of graphene oxide/TiO2 nanoparticle hybrid films. The resulting MSCs exhibit high volumetric capacitance of 233...
March 28, 2017: ACS Nano
https://www.readbyqxmd.com/read/28346890/high-throughput-system-wide-engineering-and-screening-for-microbial-biotechnology
#8
REVIEW
Yannick Vervoort, Alicia Gutiérrez Linares, Miguel Roncoroni, Chengxun Liu, Jan Steensels, Kevin J Verstrepen
Genetic engineering and screening of large number of cells or populations is a crucial bottleneck in today's systems biology and applied (micro)biology. Instead of using standard methods in bottles, flasks or 96-well plates, scientists are increasingly relying on high-throughput strategies that miniaturize their experiments to the nanoliter and picoliter scale and the single-cell level. In this review, we summarize different high-throughput system-wide genome engineering and screening strategies for microbes...
March 24, 2017: Current Opinion in Biotechnology
https://www.readbyqxmd.com/read/28346787/assembly-and-speed-in-ion-exchange-based-modular-phoretic-micro-swimmers
#9
Ran Niu, Denis Botin, Julian Weber, Alexander Reinmüller, Thomas Palberg
We report an experimental study on ion-exchange based modular micro-swimmers in low-salt water. Cationic ion-exchange particles and passive cargo particles assemble into self-propelling complexes, showing self-propulsion at speeds of several microns per second over extended distances and times. We quantify the assembly and speed of the complexes for different combinations of ion exchange particles and cargo particles, substrate types, salt types and concentrations, and cell geometries. Irrespective of experimental boundary conditions, we observe a regular development of the assembly shape with increasing number of cargo...
March 27, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28346390/the-effect-and-mechanism-of-transdermal-penetration-enhancement-of-fu-s-cupping-therapy-new-physical-penetration-technology-for-transdermal-administration-with-traditional-chinese-medicine-tcm-characteristics
#10
Wei-Jie Xie, Yong-Ping Zhang, Jian Xu, Xiao-Bo Sun, Fang-Fang Yang
BACKGROUND: In this paper, a new type of physical penetration technology for transdermal administration with traditional Chinese medicine (TCM) characteristics is presented. Fu's cupping therapy (FCT), was established and studied using in vitro and in vivo experiments and the penetration effect and mechanism of FCT physical penetration technology was preliminarily discussed. METHODS: With 1-(4-chlorobenzoyl)-5-methoxy-2-methylindole-3-ylacetic acid (indomethacin, IM) as a model drug, the establishment of high, medium, and low references was completed for the chemical permeation system via in vitro transdermal tests...
March 27, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28346008/wnt-%C3%AE-catenin-signaling-is-required-for-distraction-osteogenesis-in-rats
#11
Xuemei Wang, En Luo, Ruiye Bi, Bin Ye, Jing Hu, Shujuan Zou
OVERVIEW: The Wnt signaling pathway plays crucial roles in embryonic skeletal development and postnatal bone regeneration. However, mechanisms of Wnt signaling functioning in distraction osteogenesis (DO) haven't been well characterized. MATERIALS AND METHODS: We established a DO model using Sprague-Dawley rat tibia. And a Wnt signaling blocking agent, recombinant rat Dickkopf-related protein 1 (rrDkk1), was locally applied in the distracted gap to study the role of Wnt signaling during DO process...
March 1, 2017: Connective Tissue Research
https://www.readbyqxmd.com/read/28345927/stable-superwetting-meshes-for-on-demand-separation-of-immiscible-oil-water-mixtures-and-emulsions
#12
Mingming Liu, Yuanyuan Hou, Jing Li, Zhiguang Guo
Oil-water separation is of great importance for the treatment of oily wastewater, including immiscible light/heavy oil-water mixtures, oil-in-water or water-in-oil emulsions. Recently, interfacial materials (especially filtration membranes) with special wettability have been broadly developed to solve the environmental problems by virtue of their advantages in energy saving, high flux and good selectivity. However, the given wetting property (superhydrophilicity or superhydrophobicity) and pore size and poor stability of filtration membranes limit their widespread applications, which is far from meeting a wide variety of oil polluted water...
March 27, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28345869/characterization-of-the-aerosol-based-synthesis-of-uranium-particles-as-a-potential-reference-material-for-micro-analytical-methods
#13
Ronald Middendorp, Martin Dürr, Alexander Knott, Fabien Pointurier, Dario Ferreira Sanchez, Valerie Ann Samson, Daniel Grolimund
A process for production of micrometer-sized particles composed of uranium oxide using aerosol spray pyrolysis is characterized with respect to the various production parameters. The aerosol is generated using a vibrating orifice aerosol generator providing monodisperse droplets, which are oxidized in a subsequent heat treatment. The final particles are characterized with micro analytical methods to determine size, shape, internal morphology, chemical and structural properties in order to assess the suitability of the produced particles as a reference material for micro analytical methods, in particular for mass-spectrometry...
March 27, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28345691/surface-plasmon-resonance-imaging-for-abh-antigen-detection-on-red-blood-cells-and-in-saliva-secretor-status-related-abo-subgroup-identification
#14
Patjaree Peungthum, Krisda Sudprasert, Ratthasart Amarit, Armote Somboonkaew, Boonsong Sutapun, Apirom Vongsakulyanon, Wuttigrai Seedacoon, Pimpun Kitpoka, Mongkol Kunakorn, Toemsak Srikhirin
Low antigenic expression of ABO subgroup system on red blood cell (RBC) is cause of discrepancy between forward and reverse blood typing in the standard agglutination technique. Neutralization agglutination is employed for verification of the detection of ABH substances in saliva. However, the neutralization technique is complicated, time-consuming and requires expertise. To overcome these drawbacks, surface plasmon resonance (SPR) imaging was developed for ABH antigen detection on RBCs and in saliva. An antibody array was designed to classify the ABO subgroups by anti-A, anti-B, and anti-H antibodies; the array was immobilized on a carboxymethyl-dextran sensor-surface...
March 27, 2017: Analyst
https://www.readbyqxmd.com/read/28345687/recent-advances-in-high-performance-fluorescent-and-bioluminescent-rna-imaging-probes
#15
REVIEW
Yuqiong Xia, Ruili Zhang, Zhongliang Wang, Jie Tian, Xiaoyuan Chen
RNA plays an important role in life processes. Imaging of messenger RNAs (mRNAs) and micro-RNAs (miRNAs) not only allows us to learn the formation and transcription of mRNAs and the biogenesis of miRNAs involved in various life processes, but also helps in detecting cancer. High-performance RNA imaging probes greatly expand our view of life processes and enhance the cancer detection accuracy. In this review, we summarize the state-of-the-art high-performance RNA imaging probes, including exogenous probes that can image RNA sequences with special modification and endogeneous probes that can directly image endogenous RNAs without special treatment...
March 27, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/28345597/post-traumatic-osteoarthritis-in-mice-following-mechanical-injury-to-the-synovial-joint
#16
Muhammad Farooq Rai, Xin Duan, James D Quirk, Nilsson Holguin, Eric J Schmidt, Nobuaki Chinzei, Matthew J Silva, Linda J Sandell
We investigated the spectrum of lesions characteristic of post-traumatic osteoarthritis (PTOA) across the knee joint in response to mechanical injury. We hypothesized that alteration in knee joint stability in mice reproduces molecular and structural features of PTOA that would suggest potential therapeutic targets in humans. The right knees of eight-week old male mice from two recombinant inbred lines (LGXSM-6 and LGXSM-33) were subjected to axial tibial compression. Three separate loading magnitudes were applied: 6N, 9N, and 12N...
March 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28345583/synergistic-effects-of-micro-electrolysis-photocatalysis-on-water-treatment-and-fish-performance-in-saline-recirculating-aquaculture-system
#17
Zhangying Ye, Shuo Wang, Weishan Gao, Haijun Li, Luowei Pei, Mingwei Shen, Songming Zhu
A new physico-chemical process for TAN (total ammonia nitrogen) removal and disinfection is introduced in saline recirculating aquaculture system (RAS), in which the biofilter is replaced with an integrated electrolysis cell and an activated carbon filter. The electrolysis cell which is based on micro current electrolysis combined with UV-light was self-designed. After the fundamental research, a small pilot scale RAS was operated for 30 days to verify the technical feasibility. The system was stocked by 42 GIFT tilapia (Oreochromis niloticus) fish with the rearing density of 13 kg/m(3)...
March 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28345454/genome-wide-profiling-of-micro-rna-expression-in-gefitinib-resistant-human-lung-adenocarcinoma-using-microarray-for-the-identification-of-mir-149-5p-modulation
#18
Yong Hu, Xiaobing Qin, Dali Yan, Haixia Cao, Leilei Zhou, Fan Fan, Jialan Zang, Jie Ni, Xiaoyue Xu, Huanhuan Sha, Siwen Liu, Shaorong Yu, Jianzhong Wu, Rong Ma, Jifeng Feng
To understand the mechanism involved in gefitinib resistance, we established gefitinib-resistant human HCC827/GR-8-1 cell line from the parental HCC827 cell line. We compared the micro-RNA expression profiles of the HCC827 cells HCC827/GR-8-1 using Agilent micro-RNA microarrays. The micro-RNAs, such as the miR-149-5p, were up- or downregulated and associated with acquired gefitinib resistance. Quantitative real-time polymerase chain reaction was then performed to verify the expression patterns of different micro-RNAs...
March 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28345449/fabrication-of-pcl-plga-bcp-porous-scaffold-for-bone-tissue-engineering-applications
#19
Nguyen Thi Hiep, Huynh Chan Khon, Nguyen Dai Hai, Lee-Byong Taek, Vo Van Toi, Le Thanh Hung
In this study, biomimic porous polycaprolactone/poly (lactide-co-glycolide) loading biphasic tricalcium phosphate (PCL/PLGA-BCP) scaffolds were fabricated successfully by solvent evaporation method. The distribution of biphasic tricalcium phosphate (BCP) in polycaprolactone/poly (lactide-co-glycolide) (PCL/PLGA) scaffold was confirmed by micro-computed tomography (micro-CT) scanning, scanning electron microscope (SEM) observation and Energy-dispersive X-ray Spectroscopy (EDS) analysis. The hydrophilicity of the scaffolds was confirmed by contact angle measurement...
March 26, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28345411/corrigendum-to-depth-dependent-glycosaminoglycan-concentration-in-articular-cartilage-by-quantitative-contrast-enhanced-micro-computed-tomography
#20
(no author information available yet)
Owing to the errors made by the authors, Mittelstaedt D and Xia Y, the following article contains error. Mittelstaedt D, Xia Y. Depth-Dependent Glycosaminoglycan Concentration in Articular Cartilage by Quantitative Contrast-Enhanced Micro-Computed Tomography. Cartilage. 2015;6:216-25. Original doi: 10.1177/1947603515596418.
April 2017: Cartilage
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