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https://www.readbyqxmd.com/read/29775946/il-9-exhibits-elevated-expression-in-osteonecrosis-of-femoral-head-patients-and-promotes-cartilage-degradation-through-activation-of-jak-stat-signaling-in-vitro
#1
Wei Geng, Wen Zhang, Jinzhu Ma
Osteonecrosis of the femoral head (ONFH) often causes severe symptoms in young people and limits the mobility of the hip joint. Interleukin-9 (IL-9) is a multi-functional inflammatory factor that participates in lumbar disk herniation and arthritis and has been reported in many studies. However, the correlation between IL-9 and ONFH is unclear. The present study aimed to determine the role of IL-9 in the pathogenetic mechanism of osteonecrosis. To assess IL-9 expression in ONFH and femoral neck fracture patients, cartilage tissue was examined through western blot analysis and immunohistochemistry...
May 15, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29763429/factors-affecting-femoral-rotational-angle-based-on-the-posterior-condylar-axis-in-gap-based-navigation-assisted-total-knee-arthroplasty-for-valgus-knee
#2
Sung-Sahn Lee, Yong-In Lee, Dong-Uk Kim, Dae-Hee Lee, Young-Wan Moon
BACKGROUND: Achieving proper rotational alignment of the femoral component in total knee arthroplasty (TKA) for valgus knee is challenging because of lateral condylar hypoplasia and lateral cartilage erosion. Gap-based navigation-assisted TKA enables surgeons to determine the angle of femoral component rotation (FCR) based on the posterior condylar axis. This study evaluated the possible factors that affect the rotational alignment of the femoral component based on the posterior condylar axis...
2018: PloS One
https://www.readbyqxmd.com/read/29741735/widespread-epigenomic-transcriptomic-and-proteomic-differences-between-hip-osteophytic-and-articular-chondrocytes-in-osteoarthritis
#3
Julia Steinberg, Roger A Brooks, Lorraine Southam, Sahir Bhatnagar, Theodoros I Roumeliotis, Konstantinos Hatzikotoulas, Eleni Zengini, J Mark Wilkinson, Jyoti S Choudhary, Andrew W McCaskie, Eleftheria Zeggini
Objectives: To identify molecular differences between chondrocytes from osteophytic and articular cartilage tissue from OA patients. Methods: We investigated genes and pathways by combining genome-wide DNA methylation, RNA sequencing and quantitative proteomics in isolated primary chondrocytes from the cartilaginous layer of osteophytes and matched areas of low- and high-grade articular cartilage across nine patients with OA undergoing hip replacement surgery. Results: Chondrocytes from osteophytic cartilage showed widespread differences to low-grade articular cartilage chondrocytes...
May 8, 2018: Rheumatology
https://www.readbyqxmd.com/read/29734501/using-multidimensional-topological-data-analysis-to-identify-traits-of-hip-osteoarthritis
#4
Jasmine Rossi-deVries, Valentina Pedoia, Michael A Samaan, Adam R Ferguson, Richard B Souza, Sharmila Majumdar
BACKGROUND: Osteoarthritis (OA) is a multifaceted disease with many variables affecting diagnosis and progression. Topological data analysis (TDA) is a state-of-the-art big data analytics tool that can combine all variables into multidimensional space. TDA is used to simultaneously analyze imaging and gait analysis techniques. PURPOSE: To identify biochemical and biomechanical biomarkers able to classify different disease progression phenotypes in subjects with and without radiographic signs of hip OA...
May 7, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29732726/functional-characterisation-of-the-osteoarthritis-genetic-risk-residing-at-aldh1a2-identifies-rs12915901-as-a-key-target-variant
#5
Colin Shepherd, Dongxing Zhu, Andrew J Skelton, Jennifer Combe, Harrison Threadgold, Linyi Zhu, Tonia L Vincent, Paul Stuart, Louise N Reynard, John Loughlin
OBJECTIVE: To identify the functional single nucleotide polymorphisms (SNPs) and mechanisms conferring increased hand osteoarthritis (OA) risk at the ALDH1A2 locus, which is a retinoic acid (RA) regulatory gene. METHODS: Tissues from 247 knee, hip or hand OA patients who had undergone joint surgery were included. RNA-sequencing was used to investigate differential expression of ALDH1A2 and other RA signalling pathway genes in cartilage. ALDH1A2 expression in multiple joint tissues was quantified by qPCR...
May 6, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29730681/clinical-and-ultrasound-findings-in-patients-with-calcium-pyrophosphate-dihydrate-deposition-disease
#6
Paulina Vele, Siao-Pin Simon, Laura Damian, Ioana Felea, Laura Muntean, Ileana Filipescu, Simona Rednic
AIM: To evaluate the presence and distribution of calcium pyrophosphate (CPP) deposits in joints commonly affected by CPP deposition (CPPD) disease (acromio-clavicular, gleno-humeral, wrists, hips, knees, ankles, and symphysis pubis joints) using ultrasound (US). MATERIAL AND METHODS: Thirty consecutive patients fulfilling McCarty diagnostic criteria for CPPD were consecutively enrolled in the study. The data registered using the US included the affected joints, the calcification site, and the pattern of calcification (thin hyperechoic bands, parallel to the surface of the hyaline cartilage, hyperechoic spots, and hyperechoic nodular or oval deposits)...
May 2, 2018: Medical Ultrasonography
https://www.readbyqxmd.com/read/29730219/prevalence-of-high-grade-cartilage-defects-in-patients-with-borderline-dysplasia-with-femoroacetabular-impingement-a-comparative-cohort-study
#7
Ioanna K Bolia, Karen K Briggs, Renato Locks, Jorge Chahla, Hajime Utsunomiya, Marc J Philippon
PURPOSE: To compare the prevalence, size, and location of Outerbridge grade III and IV cartilage defects on the femoral head and acetabulum between patients with borderline acetabular dysplasia and patients with non-borderline dysplasia who underwent hip arthroscopy for femoroacetabular impingement (FAI). METHODS: Patients aged 18 years or older who underwent primary hip arthroscopy for correction of FAI and labral repair from November 2005 to April 2016 were included...
May 2, 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29727407/three-dimensional-mri-analysis-of-femoral-head-remodeling-after-reduction-in-patients-with-developmental-dysplasia-of-the-hip
#8
Yuta Tsukagoshi, Hiroshi Kamada, Makoto Kamegaya, Ryoko Takeuchi, Shogo Nakagawa, Yohei Tomaru, Kenta Tanaka, Mio Onishi, Tomofumi Nishino, Masashi Yamazaki
BACKGROUND: Previous reports on patients with developmental dysplasia of the hip (DDH) showed that the prereduced femoral head was notably smaller and more nonspherical than the intact head, with growth failure observed at the proximal posteromedial area. We evaluated the shape of the femoral head cartilage in patients with DDH before and after reduction, with size and sphericity assessed using 3-dimensional (3D) magnetic resonance imaging (MRI). METHODS: We studied 10 patients with unilateral DDH (all female) who underwent closed reduction...
May 2, 2018: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/29715363/hip-joint-contact-pressure-distribution-during-pavlik-harness-treatment-of-an-infant-hip-a-patient-specific-finite-element-model
#9
Behzad Vafaeian, Samer Adeeb, Marwan El-Rich, Dornoosh Zonoobi, Abhilash R Hareendranathan, Jacob L Jaremko
Developmental dysplasia of the hip (DDH) in infants under 6 months of age is typically treated by the Pavlik harness (PH). During successful PH treatment, a subluxed/dislocated hip is spontaneously reduced into the acetabulum, and DDH undergoes self-correction. PH treatment may fail due to avascular necrosis (AVN) of the femoral head. An improved understanding of mechanical factors accounting for the success/failure of PH treatment may arise from investigating articular cartilage contact pressure (CCP) within a hip during treatment...
July 1, 2018: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/29704188/mucolipidosis-type-iii-a-series-of-adult-patients
#10
Esmee Oussoren, David van Eerd, Elaine Murphy, Robin Lachmann, Jan C van der Meijden, Lies H Hoefsloot, Rob Verdijk, George J G Ruijter, Mario Maas, Carla E M Hollak, Janneke G Langendonk, Ans T van der Ploeg, Mirjam Langeveld
BACKGROUND: Mucolipidosis type III α/β or γ (MLIII) are rare autosomal recessive diseases, in which reduced activity of the enzyme UDP-N-acetyl glucosamine-1-phosphotransferase (GlcNAc-PTase) leads to intra-lysosomal accumulation of different substrates. Publications on the natural history of MLIII, especially the milder forms, are scarce. This study provides a detailed description of the disease characteristics and its natural course in adult patients with MLIII. METHODS: In this retrospective chart study, the clinical, biochemical and molecular findings in adult patients with a confirmed diagnosis of MLIII from three treatment centres were collected...
April 27, 2018: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/29704036/evaluation-of-articular-cartilage-following-rotational-acetabular-osteotomy-for-hip-dysplasia-using-t2-mapping-mri
#11
Takeshi Shoji, Takuma Yamasaki, Soutaro Izumi, Mikiya Sawa, Yuji Akiyama, Yuji Yasunaga, Nobuo Adachi
BACKGROUND: Rotational acetabular osteotomy (RAO) is one of the surgical treatments for acetabular dysplasia, and satisfactory results have been reported. We evaluated the postoperative changes of articular cartilage and whether the pre-operative condition of the articular cartilage influences the clinical results using T2 mapping MRI. METHODS: We reviewed 31 hips with early stage osteoarthritis in 31 patients (mean age, 39.6 years), including three men and 28 women who underwent RAO for hip dysplasia...
April 27, 2018: Skeletal Radiology
https://www.readbyqxmd.com/read/29702415/robust-variational-segmentation-of-3d-bone-ct-data-with-thin-cartilage-interfaces
#12
Tarun Gangwar, Jeff Calder, Takashi Takahashi, Joan E Bechtold, Dominik Schillinger
We present a two-stage variational approach for segmenting 3D bone CT data that performs robustly with respect to thin cartilage interfaces. In the first stage, we minimize a flux-augmented Chan-Vese model that accurately segments well-separated regions. In the second stage, we apply a new phase-field fracture inspired model that reliably eliminates spurious bridges across thin cartilage interfaces, resulting in an accurate segmentation topology, from which each bone object can be identified. Its mathematical formulation is based on the phase-field approach to variational fracture, which naturally blends with the variational approach to segmentation...
April 17, 2018: Medical Image Analysis
https://www.readbyqxmd.com/read/29696319/danish-hip-arthroscopy-registry-predictors-of-outcome-in-patients-with-femoroacetabular-impingement-fai
#13
Bjarne Mygind-Klavsen, Bent Lund, Torsten Grønbech Nielsen, Niels Maagaard, Otto Kraemer, Per Hölmich, Søren Winge, Martin Lind
PURPOSE: Predictors of outcome after femoroacetabular impingement (FAI) surgery are not well-documented. This study presents data from the Danish Hip Arthroscopy Registry (DHAR) for such analyses. The purpose of this study was to identify predictors of poor outcome after FAI surgery in a Danish FAI population. The primary hypothesis was that older patients, patients with severe cartilage damage and female patients might have inferior outcome results compared with younger patients, patients with minor cartilage damage and male patients...
April 25, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29662770/predicting-the-collapse-of-the-femoral-head-due-to-osteonecrosis-from-basic-methods-to-application-prospects
#14
REVIEW
Leilei Chen, GuoJu Hong, Bin Fang, Guangquan Zhou, Xiaorui Han, Tianan Guan, Wei He
Collapse of the femoral head is the most significant pathogenic complication arising from osteonecrosis of the femoral head. It is related to the disruption of the maintenance of cartilage and bone, and results in an impaired function of the vascular component. A method for predicting the collapse of the femoral head can be treated as a type of clinical index. Efforts in recent years to predict the collapse of the femoral head due to osteonecrosis include multiple methods of radiographic analysis, stress distribution analysis, finite element analysis, and other innovative methods...
October 2017: Journal of Orthopaedic Translation
https://www.readbyqxmd.com/read/29658534/the-influence-of-osteoporotic-bone-structures-of-the-pelvic-hip-complex-on-stress-distribution-under-impact-load
#15
Katarzyna Arkusz, Tomasz Klekiel, Niezgoda Niezgoda, Romuald Będziński
PURPOSE: The aim of this study was to determine the effect of bone mineral density (BMD) on the stress distribution in pelvic-hip complex (PHC) model which included bone structures and soft tissues. Bone mass changes in osteoporosis and osteopenia were considered in this analysis. In addition, the relations between force direction and stress distribution causing PHC fractures were determined. METHODS: This paper presents the development and validation of a detailed 3D finite element model with high anatomical fidelity of the PHC and BMD changes in trabecular and cortical bones, modelled based on CT scans...
2018: Acta of Bioengineering and Biomechanics
https://www.readbyqxmd.com/read/29643866/joint-genomic-prediction-of-canine-hip-dysplasia-in-uk-and-us-labrador-retrievers
#16
Stefan M Edwards, John A Woolliams, John M Hickey, Sarah C Blott, Dylan N Clements, Enrique Sánchez-Molano, Rory J Todhunter, Pamela Wiener
Canine hip dysplasia, a debilitating orthopedic disorder that leads to osteoarthritis and cartilage degeneration, is common in several large-sized dog breeds and shows moderate heritability suggesting that selection can reduce prevalence. Estimating genomic breeding values require large reference populations, which are expensive to genotype for development of genomic prediction tools. Combining datasets from different countries could be an option to help build larger reference datasets without incurring extra genotyping costs...
2018: Frontiers in Genetics
https://www.readbyqxmd.com/read/29629574/acetabular-delamination-epidemiology-histological-features-and-treatment
#17
Eugenio Jannelli, Antonina Parafioriti, Alberto Acerbi, Alessandro Ivone, Alberto Fioruzzi, Andrea Fontana
Objective The International Cartilage Repair Society classification is the one mainly used to define chondral defects. However, this classification does not include delamination. The objective of the study is to describe the characteristics of this lesion to better explain its classification in the context of chondral lesions of the hip. Design We performed a retrospective analysis of 613 patients who underwent hip arthroscopy. In this group, the incidence, localization, histological characteristics, and association to femoroacetabular impingement as well as to other intraarticular lesions of acetabular delamination (AD) were analyzed...
April 1, 2018: Cartilage
https://www.readbyqxmd.com/read/29579721/the-influence-of-isolated-femur-and-tibia-rotations-on-patella-cartilage-stress-a-sensitivity-analysis
#18
Tzu-Chieh Liao, Li Yin, Christopher M Powers
BACKGROUND: To determine the influence of femur and tibia rotations in the transverse and frontal planes on patella cartilage stress. METHODS: Patella cartilage stress profiles of six healthy females were obtained during a squatting task using subject-specific finite element models of the patellofemoral joint (45° of knee flexion). Input parameters for the finite element model included joint geometry, quadriceps muscle forces, and weight-bearing patellofemoral joint kinematics...
March 12, 2018: Clinical Biomechanics
https://www.readbyqxmd.com/read/29578868/hip-joint-effusion-synovitis-is-associated-with-hip-pain-and-sports-recreation-function-in-female-professional-ballet-dancers
#19
Susan Mayes, April-Rose Ferris, Peter Smith, Jill Cook
OBJECTIVE: To compare hip joint effusion-synovitis prevalence in professional ballet dancers with nondancing athletes and to evaluate the relationship between effusion-synovitis and clinical measures and cartilage defects. DESIGN: Case-control study. SETTING: Elite ballet and sport. PARTICIPANTS: Forty-nine professional ballet dancers and 49 age-matched and sex-matched athletes. INDEPENDENT VARIABLES: Group (dancers/athletes), sex, age, years of training, Copenhagen Hip and Groin Outcome Scores (HAGOSs), hip rotation range of motion (ROM), generalized joint hypermobility (GJH), and hip cartilage defect scores...
March 23, 2018: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/29573913/fresh-osteochondral-allograft-transplantation-for-treatment-of-large-cartilage-defects-of-the-femoral-head-a-minimum-two-year-follow-up-study-of-twenty-two-patients
#20
Xin Y Mei, Ibrahim S Alshaygy, Oleg A Safir, Allan E Gross, Paul R Kuzyk
BACKGROUND: Controversy remains over the surgical management of large osteochondral lesions of the femoral head in young, active patients. The purpose of this study is to assess midterm clinical and radiographic outcomes after fresh osteochondral allograft transplantation (OAT) for large femoral head lesions at minimum 2-year follow-up. METHODS: A retrospective review of prospectively collected data was performed for 22 patients under the age of 50 years with defined femoral head osteochondral lesions who underwent fresh OAT between 2008 and 2015...
February 9, 2018: Journal of Arthroplasty
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