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https://www.readbyqxmd.com/read/29330619/mr-arthrography-of-the-hip-diagnostic-performance-and-image-quality-of-3d-steady-state-free-precession-versus-2d-turbo-spin-echo-sequences
#1
Mareen Sarah Kraus, Mike Notohamiprodjo, Sasan Partovi, Ahmed Sobieh, Andrea Baur-Melnyk, Joerg Hausdorf, Ulrich Grosse
OBJECTIVE: To retrospectively compare the diagnostic performance of isotropic 3D steady-state free precession (3D-SSFP) sequences with 2D turbo spin-echo proton density-weighted fat-saturated (2D-TSE-PD fs) images in hip magnetic resonance arthrography; arthroscopy was a standard of reference. METHODS: Eighty-one patients with suspected labral tears who underwent hip MR arthrography (3-T scanner) were included. 2D-TSE-PD fs sequences were acquired in three planes and a singular sagittal 3D-SSFP...
January 12, 2018: Skeletal Radiology
https://www.readbyqxmd.com/read/29318429/effect-of-intra-articular-injection-of-intermediate-weight-hyaluronic-acid-on-hip-and-knee-cartilage-in-vivo-evaluation-using-t2-mapping
#2
Giulio Ferrero, Luca Maria Sconfienza, Francesco Fiz, Emanuele Fabbro, Angelo Corazza, Daniele Dettore, Davide Orlandi, Carlo Castellazzo, Stefano Tornago, Giovanni Serafini
OBJECTIVES: We used T2 mapping to quantify the effect of intra-articular hyaluronic acid administration (IAHAA) on cartilage with correlation to clinical symptoms. METHODS: One hundred two patients with clinical and MRI diagnosis of hip or knee grade I-III chondropathy were prospectively included. All patients received a standard MRI examination of the affected hip/knee (one joint/patient) and T2-mapping multiecho sequence for cartilage evaluation. T2 values of all slices were averaged and used for analysis...
January 9, 2018: European Radiology
https://www.readbyqxmd.com/read/29309831/mutant-cartilage-oligomeric-matrix-cartilage-comp-compromises-bone-integrity-joint-function-and-the-balance-between-adipogenesis-and-osteogenesis
#3
Francoise Coustry, Karen L Posey, Tristan Maerz, Kevin Baker, Annie M Abraham, Catherine G Ambrose, Sabah Nobakhti, Sandra J Shefelbine, Xiaohong Bi, Michael Newton, Karissa Gawronski, Lindsay Remer, Alka C Veerisetty, Mohammad G Hossain, Frankie Chiu, Jacqueline T Hecht
Mutations in COMP (cartilage oligomeric matrix protein) cause severe long bone shortening in mice and humans. Previously, we showed that massive accumulation of misfolded COMP in the ER of growth plate chondrocytes in our MT-COMP mouse model of pseudoachondroplasia (PSACH) causes premature chondrocyte death and loss of linear growth. Premature chondrocyte death results from activation of oxidative stress and inflammation through the CHOP-ER pathway and is reduced by removing CHOP or by anti-inflammatory or antioxidant therapies...
January 5, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29309383/analysis-of-acetabular-ossification-from-the-triradiate-cartilage-and-secondary-centers
#4
Kevin C Parvaresh, Andrew T Pennock, James D Bomar, Dennis R Wenger, Vidyadhar V Upasani
BACKGROUND: Acetabular development is a complex process that involves both endochondral growth from the triradiate cartilage (TRC) and intramembranous growth from the primary and secondary ossification centers of the innominate bones. Ponseti and others have described these centers including their contribution toward the development of normal acetabular shape. Prior studies have not utilized advanced imaging to study the appearance and closure of these secondary centers. The purpose of this study was to determine the chronological age at which the secondary ossification centers of the acetabulum appear and close and where there are any sex differences...
January 5, 2018: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/29305458/hemiarthroplasty-proximal-femoral-endoprostheses-following-tumour-reconstruction-is-acetabular-replacement-necessary
#5
J D Stevenson, V S Kumar, G L Cribb, P Cool
AIMS: Dislocation rates are reportedly lower in patients requiring proximal femoral hemiarthroplasty than for patients undergoing hip arthroplasty for neoplasia. Without acetabular replacement, pain due to acetabular wear necessitating revision surgery has been described. We aimed to determine whether wear of the native acetabulum following hemiarthroplasty necessitates revision surgery with secondary replacement of the acetabulum after proximal femoral replacement (PFR) for tumour reconstruction...
January 2018: Bone & Joint Journal
https://www.readbyqxmd.com/read/29299482/have-the-annual-trends-of-total-hip-arthroplasty-in-rheumatoid-arthritis-patients-decreased
#6
Kemjika O Onuoha, Max Solow, Jared M Newman, Nipun Sodhi, Robert Pivec, Anton Khlopas, Assem A Sultan, Morad Chughtai, Neil V Shah, Jaiben George, Michael A Mont
Background: Rheumatoid arthritis (RA) is characterized by chronic systemic and synovial inflammation, resulting in damage to both cartilage and bone. Medical treatment, which has increasingly relied upon disease modifying anti-rheumatic drugs (DMARDs), may fail to slow disease progression and limit joint damage, ultimately warranting surgical intervention. Up to 25% of RA patients will require lower extremity total joint arthroplasty. Though total hip arthroplasty (THA) is known to improve quality of life and functional measures, clarification is still required with respect to the impact of increased DMARD use on annual rates of THA...
December 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29287118/serum-n-propeptide-of-collagen-iia-piianp-as-a-marker-of-radiographic-osteoarthritis-burden
#7
Hikmat N Daghestani, Joanne M Jordan, Jordan B Renner, Michael Doherty, A Gerry Wilson, Virginia B Kraus
OBJECTIVE: Cartilage homeostasis relies on a balance of catabolism and anabolism of cartilage matrix. Our goal was to evaluate the burden of radiographic osteoarthritis and serum levels of type IIA procollagen amino terminal propeptide (sPIIANP), a biomarker representing type II collagen synthesis, in osteoarthritis. METHODS: OA burden was quantified on the basis of radiographic features as total joint faces with an osteophyte, joint space narrowing, or in the spine, disc space narrowing...
2017: PloS One
https://www.readbyqxmd.com/read/29250341/results-of-hip-arthroscopy-in-patients-with-mri-diagnosis-of-subchondral-cysts-a-case-series
#8
David E Hartigan, Itay Perets, Leslie C Yuen, Benjamin G Domb
The aim of this article is to examine the results of arthroscopic management of patients with labral pathology who have preoperative magnetic resonance images (MRIs) demonstrating subchondral cysts. This institution's database was searched for patients who underwent hip arthroscopy and had subchondral cysts on MRI and >2-year follow-up. Exclusion criteria included previous hip surgery, Tönnis grade >1, inflammatory arthritis, Perthes, slipped capital femoral epiphysis or abductor repair. Patient-reported outcome (PRO) scores including visual analog scale, modified Harris hip score (mHHS), non-arthritic hip score and hip outcome score sports-specific subscale (HOS-SSS) were gathered preoperatively, at 3 months, and annually thereafter...
December 2017: Journal of Hip Preservation Surgery
https://www.readbyqxmd.com/read/29250336/preoperative-planning-for-redirective-periacetabular-osteotomies
#9
REVIEW
Christoph E Albers, Piet Rogers, Nicholas Wambeek, Sufian S Ahmad, Piers J Yates, Gareth H Prosser
Redirective, periacetabular osteotomies (PAO) represent a group of surgical procedures for treatment of developmental dysplasia of the hip (DDH) in skeletally mature and immature patients. The ultimate goal of all procedures is to reduce symptoms, improve function and delay or prevent progression of osteoarthritis. During the last two decades, the understanding of the underlying pathomechanisms has continuously evolved. This is mainly attributable to the development of the femoroacetabular impingement concept that has increased the awareness of the underlying three-dimensional complexity associated with DDH...
December 2017: Journal of Hip Preservation Surgery
https://www.readbyqxmd.com/read/29249340/fully-automated-segmentation-of-a-hip-joint-using-the-patient-specific-optimal-thresholding-and-watershed-algorithm
#10
Jung Jin Kim, Jimin Nam, In Gwun Jang
BACKGROUND AND OBJECTIVE: Automated segmentation with high accuracy and speed is a prerequisite for FEA-based quantitative assessment with a large population. However, hip joint segmentation has remained challenging due to a narrow articular cartilage and thin cortical bone with a marked interindividual variance. To overcome this challenge, this paper proposes a fully automated segmentation method for a hip joint that uses the complementary characteristics between the thresholding technique and the watershed algorithm...
February 2018: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29242964/-bone-substitute-materials-as-local-drug-carriers-current-status-of-substitutes-of-various-origins
#11
REVIEW
K-D Kühn, C Berberich, H Bösebeck
BACKGROUND: Autologous bone grafts (autografts) are used in surgery for defect filling and impaction grafting during hip socket and femur reconstruction. Because of their superior osteoinductive capacity, autografts are considered the "gold standard" for these treatments. However, because of a better cost-benefit ratio, allografts are also often used. In the case of limited donor availability for autologous or allogenic bone grafts, bone substitute materials (BSMs) are a reasonable alternative or supplement...
December 14, 2017: Der Orthopäde
https://www.readbyqxmd.com/read/29234663/reconstruction-with-iliac-pedestal-cup-and-proximal-femur-tumor-prosthesis-after-wide-resection-of-chondrosarcoma-10-year-follow-up-results
#12
Diogo Lino Moura, Rúben Fonseca, João Freitas, António Figueiredo, José Casanova
Chondrosarcoma is a malignant cartilage-forming neoplasm. It is difficult to treat because of resistance to both chemotherapy and radiation, making wide local excision the only treatment. This report presents an active, 43 year-old man who was diagnosed with recurrent clear cell chondrosarcoma of the proximal left femur, previously reconstructed with a total hip prosthesis, extending to the weight-bearing dome of the acetabulum. Cancer staging study revealed no signs of tumor dissemination at distance. Given the excellent functional status of the patient, the authors performed a Enneking-Dunham type periacetabular pelvic resection and resected en bloc, with the total hip prosthesis including 22 cm of the femur and a portion of the hip abductor apparatus...
November 2017: Revista Brasileira de Ortopedia
https://www.readbyqxmd.com/read/29229239/in-vivo-postoperative-motion-analysis-of-metal-and-ceramic-bipolar-hip-hemiarthroplasty
#13
Toru Yoshioka, Nobukazu Okimoto, Yoshifumi Fuse, Makoto Kawasaki, Toshiharu Mori, Akinori Sakai, Tokifumi Majima
BACKGROUND: We hypothesized that ceramic bipolar shows less impingement between stem neck and outer head compared to metal bipolar, because of its low coefficient of friction with the acetabulum cartilage. In this paper, a three dimensional (3D) postoperative motion analysis has been used to assess the different motion characteristics of metal and ceramic bipolar hip hemiarthroplasty systems. METHODS: This study was conducted on 40 patients divided in two matched cohorts: 20 patients with metal bipolar and 20 patients with the ceramic bipolar...
December 8, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/29228594/bone-strengthening-pill-bsp-promotes-bone-cell-and-chondrocyte-repair-and-the-clinical-and-experimental-study-of-bsp-in-the-treatment-of-osteonecrosis-of-the-femoral-head
#14
Zheng Li, Lulin Wang, Jin Wei, Liguo Zhu, Xisheng Weng, Jin Jin, Hong Xiao, Jun Zhang, Heming Wang, Guantong Shi, Lingpeng Pei, Fangde Zou, Wanqiang Zhang, Tianzun Tao, Xin Dong
About 1 in 3 people suffer from bone and joint disease, which is a disease of bone and cartilage cells. Osteonecrosis of the femoral head (ONFH) is a typical example of bone and joint disease involving bone cell necrosis. Osteonecrosis of the femoral head leads to the occurrence of premature osteoarthritis of the hip and collapse of the cartilage cells, and there is currently no effective drug treatment available. In order to study the effects of "bone-strengthening pill" (BSP) on the repair of bone and cartilage cells, we investigated the potential effects of the herbal mixture BSP in an animal model of avascular necrosis of the femoral head and in patients...
November 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/29226162/relationship-between-age-at-onset-of-symptoms-and-intraoperative-findings-in-hip-arthroscopic-surgery
#15
Carlos Suarez-Ahedo, Chengcheng Gui, Stephanie M Rabe, John P Walsh, Sivashankar Chandrasekaran, Benjamin G Domb
Background: Hip arthroscopic surgery is intended to treat multiple abnormalities in an effort to delay the progression to osteoarthritis, especially in young patients. However, the length of time in which patients experience joint pain before seeking a specialist for a diagnosis can delay hip preservation surgery and influence clinical outcomes. Purpose: To investigate the relationship between age at symptom onset and findings during hip arthroscopic surgery as well as outcomes after 2 years of clinical follow-up...
November 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29225159/histopathology-of-periarticular-non-hereditary-heterotopic-ossification
#16
REVIEW
Kristin L Foley, Nader Hebela, Mary Ann Keenan, Robert J Pignolo
In the mature adult skeleton, new bone formation is normally restricted to regeneration of osseous tissue at sites of fracture. However, heterotopic ossification, or the formation of bone outside the normal skeleton, can occur within muscle, adipose, or fibrous connective tissue. Periarticular non-hereditary heterotopic ossification (NHHO) may occur after musculoskeletal trauma, following CNS injury, with certain arthropathies, or following injury or surgery that is often sustained in the context of age-related pathology...
December 7, 2017: Bone
https://www.readbyqxmd.com/read/29218684/feasibility-of-arthroscopic-autologous-chondrocyte-implantation-in-the-hip-using-an-injectable-hydrogel
#17
Steffen Thier, Florian Baumann, Christel Weiss, Stefan Fickert
INTRODUCTION: In the long term the treatment of articular cartilage defects of the hip has the most direct impact on the postoperative outcome and should diminish degenerative changes caused by different pathologies. The purpose of this prospective feasibility study is to describe technical aspects of arthroscopic, injectable autologous chondrocyte implantation in the hip and to report the short-term outcome. METHODS: Full-thickness cartilage defects of 13 patients were treated arthroscopically with an injectable autologous chondrocyte transplantation product (Novocart Inject, Tetec) in a 2-step surgical procedure...
December 8, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/29208853/investigations-of-cartilage-matrix-degeneration-in-patients-with-early-stage-femoral-head-necrosis
#18
Ronghua Xu, Bo Wei, Jiayi Li, Chenyu Huang, Rongcai Lin, Cheng Tang, Yan Xu, Qingqiang Yao, Liming Wang
BACKGROUND The purpose of this study was to explore changes in cartilage matrix in early-stage femoral head necrosis (FHN). MATERIAL AND METHODS Femoral head samples of patients with early FHN were collected during total hip arthroplasty (THA), high-field 7.0T MRI scans were performed in vitro, and the average T2 values were calculated. Cartilage samples were obtained from the weight-bearing area (FHN group) and non-weight-bearing area (Control group), divided into 3 equal parts and used for biochemical analysis, histopathological staining, and gene expression analysis...
December 6, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29192936/outcomes-of-femoral-head-marrow-stimulation-techniques-at-minimum-2-year-follow-up
#19
David E Hartigan, Itay Perets, Edwin O Chaharbakhshi, John P Walsh, Leslie C Yuen, Benjamin G Domb
This study compared patients who underwent femoral head microfracture with a control group of patients who did not require microfracture. Patients had more than 2 years of follow-up. The patient groups had similar demographic and radiographic features, including sex, age within 5 years, body mass index within 5 points, equal Tönnis grade, lateral center edge angle within 5°, labral treatment, and capsular closure vs release. Inclusion criteria were a minimum of 2 years of follow-up, Outerbridge grade IV cartilage damage, and femoral head marrow stimulation technique performed at the time of arthroscopy...
November 30, 2017: Orthopedics
https://www.readbyqxmd.com/read/29172934/early-osteoarthritis-after-slipped-capital-femoral-epiphysis
#20
Lukas Helgesson, Peter Kälebo Johansson, Ylva Aurell, Carl-Johan Tiderius, Johan Kärrholm, Jacques Riad
Background and purpose - Slipped capital femoral epiphysis (SCFE) results in a more or less pronounced deformity of the proximal femur, sometimes causing impingement and early osteoarthritis. We studied early osteoarthritis after SCFE and the association with deformity and self-reported hip function, pain, and quality of life. Patients and methods - 9 women and 16 men, mean age 32 (21-50) years, 19 with unilateral and 6 with bilateral SCFE, participated. All patients had primarily been operated by pin or screw with no attempt at reposition of the slip...
November 27, 2017: Acta Orthopaedica
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