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https://www.readbyqxmd.com/read/28213129/cyclic-compressive-stress-induced-scinderin-regulates-progress-of-developmental-dysplasia-of-the-hip
#1
Cheng-Long Wang, Hui Wang, Fei Xiao, Chuan-Dong Wang, Guo-Li Hu, Jun-Feng Zhu, Chao Shen, Bin Zuo, Yi-Min Cui, De Li, Yuan-Gao, Xiao-Ling Zhang, Xiao-Dong Chen
Developmental dysplasia of the hip (DDH) is a common musculoskeletal disorder characterized by a mismatch between acetabulum and femoral head. Mechanical force plays an important role during the occurrence and development of abnormities in acetabulum and femoral head. In this study, we established a mechanical force model named cyclic compressive stress (Ccs). To analyze the effect of Ccs on DDH, we detected special genes in chondrocytes and osteoblasts. Results showed that Ccs downregulated chondrogenesis of ADTC5 in a concentration-dependent manner...
February 14, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28209345/multiobjective-optimization-of-cartilage-stress-for-non-invasive-patient-specific-recommendations-of-high-tibial-osteotomy-correction-angle-a-novel-method-to-investigate-alignment-correction
#2
Keke Zheng, Corey J Scholes, Junning Chen, David Parker, Qing Li
Medial opening wedge high tibial osteotomy (MOWHTO) is a surgical procedure to treat knee osteoarthritis associated with varus deformity. However, the ideal final alignment of the Hip-Knee-Ankle (HKA) angle in the frontal plane, that maximizes procedural success and post-operative knee function, remains controversial. Therefore, the purpose of this study was to introduce a subject-specific modeling procedure in determining the biomechanical effects of MOWHTO alignment on tibiofemoral cartilage stress distribution...
February 13, 2017: Medical Engineering & Physics
https://www.readbyqxmd.com/read/28202208/survivorship-analysis-of-eighty-revised-hip-arthroplasties-with-the-impaction-grafting-technique-using-whole-femoral-head-allografts-with-the-articular-cartilage
#3
Ahmed Fadulelmola, Efstathios Drampalos, John Hodgkinson, Mukesh Hemmady
BACKGROUND: Acetabular impaction bone grafting aims to restore anatomy in hip revision surgery. This is an effective but expensive and time-consuming technique. Usually, the articular cartilage is removed from the femoral head allograft. We aimed to reproduce the same results retaining the cartilage of the allograft. METHODS: Eighty acetabular revisions using impacted morselized bone graft retaining the articular cartilage and a cemented cup were studied retrospectively...
January 24, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28197751/rotational-acetabular-osteotomy-for-acetabular-dysplasia-and-osteoarthritis-a-mean-follow-up-of-20%C3%A2-years
#4
Takahito Yuasa, Katsuhiko Maezawa, Kazuo Kaneko, Masahiko Nozawa
INTRODUCTION: Rotational acetabular osteotomy (RAO), a joint-conserving surgery in which the femoral head coverage by autologous cartilage is improved to achieve joint stability, is one of the most common joint-conserving surgeries for acetabular dysplasia of the hip in adult patients. Favorable outcome of RAO for pre- and initial coxarthrosis has been reported with middle- to long-term observation; however, surgery should be selected for advanced coxarthrosis. The objective of this study was to investigate the long-term clinical outcomes and radiological arthritis changes in patients who were treated with RAO and could be followed for 15 years or longer, and to investigate the joint conservation rate by preoperative arthritis stage...
February 14, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28197696/large-meniscus-extrusion-ratio-is-a-poor-prognostic-factor-of-conservative-treatment-for-medial-meniscus-posterior-root-tear
#5
Yoon-Ho Kwak, Sahnghoon Lee, Myung Chul Lee, Hyuk-Soo Han
PURPOSE: The purpose of this study was to find a prognostic factor of medial meniscus posterior root tear (MMPRT) for surgical decision making. METHODS: Eighty-eight patients who were diagnosed as acute or subacute MMPRT without severe degeneration of the meniscus were treated conservatively for 3 months. Fifty-seven patients with MMPRT showed good response to conservative treatment (group 1), while the remaining 31 patients who failed to conservative treatment (group 2) received arthroscopic meniscus repair...
February 15, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28185391/severe-cartilage-degeneration-in-patients-with-developmental-dysplasia-of-the-hip
#6
Wei-Jia Feng, Hui Wang, Chao Shen, Jun-Feng Zhu, Xiao-Dong Chen
Developmental dysplasia of the hip (DDH) is a developmental disorder that has long-term chronic pain and limited hip joint mobility as major pathological characteristics. This study aims to access the association between the development of DDH and cartilage metabolic disorders. Cartilage tissue samples were acquired from patients with DDH, osteoarthritis (OA) and femoral neck fracture. The proteoglycan level was evaluated by safranin O-fast green, toluidine blue and hematoxylin-eosin (HE) staining. The levels of collagen-II (Col-II), collagen-X (Col-X) and metal matrix proteinase-13 (MMP-13) were evaluated by immunohistochemistry (IHC) and Western blotting analysis...
February 10, 2017: IUBMB Life
https://www.readbyqxmd.com/read/28164046/treatment-of-the-bullet-traversing-femoral-neck-lodged-in-hip-joint-initial-arthroscopic-removal-and-subsequent-cartilage-repair
#7
Mehmet Faruk Çatma, Serhan Ünlü, Önder Ersan, Alper Öztürk
INTRODUCTION: There have been several reports on arthroscopically assisted removal of the bullet imbedded in hip joint in the literature. Similarly, in this case, a bullet lodged in acetabulum was extracted with arthroscopic technique. What makes this case unique in the literature is that the bullet removed from the acetabulum traversed the femoral neck. CASE REPORT: Male patient aged 32 years with a low-velocity gunshot wound was referred to the emergency room on August 28, 2012...
September 2016: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28149716/hip-arthroscopy-for-removal-of-an-acetabular-rim-based-osteoid-osteoma-and-concomitant-femoroacetabular-impingement-correction
#8
Jacques A Denker, Hollis M Fritts, Rebecca M Stone, Christopher M Larson
Minimally invasive percutaneous radiofrequency ablation (RFA) techniques are the standard of care for treating simple osteoid osteomas (OOs). Historically, OOs were treated with open en bloc resection or curettage of the nidus. RFA procedures have been linked to soft-tissue complications of varying severity. In addition, RFA may be a poor choice for periarticular OOs because of the potential for procedure-related articular cartilage damage. Hip arthroscopy is a widely accepted approach for the treatment of femoroacetabular impingement...
December 2016: Arthroscopy Techniques
https://www.readbyqxmd.com/read/28123640/microrna-410-promotes-chondrogenic-differentiation-of-human-bone-marrow-mesenchymal-stem-cells-through-down-regulating-wnt3a
#9
Yanjie Zhang, Xiaohan Huang, Yanhao Yuan
BACKGROUND: Chondrogenic differentiation of mesenchymal stem cells (MSCs) is important for osteoarthritis (OA) treatment. However, the specific mechanisms involved are undefined. MicroRNAs (miRNAs) downregulate protein synthesis by binding to the 3'UTR of target mRNA. METHODS: Bone marrow aspirates were obtained from OA patients undergoing total hip arthroplasty (n=8) to isolate MSCs. MiR-410 or miR-410 inhibitor were transfected into MSCs using lentivirus and the effects were assessed...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28108757/degeneration-of-articular-cartilage-in-osteonecrosis-of-the-femoral-head-begins-at-the-necrotic-region-after-collapse-a-preliminary-study-using-t1-rho-mri
#10
Kazuhiko Sonoda, Goro Motomura, Satoshi Kawanami, Yukihisa Takayama, Hiroshi Honda, Takuaki Yamamoto, Yasuharu Nakashima
OBJECTIVE: The purpose of this study is to evaluate the role of collapse on the degeneration of articular cartilage in patients with osteonecrosis of the femoral head (ONFH). MATERIALS AND METHODS: Sixteen hips in 12 patients (four men, eight women; mean age, 34.8 years) with a history of systemic corticosteroid treatment were studied using T1 rho magnetic resonance imaging (MRI). Six hips had collapsed ONFH, five had non-collapsed ONFH, and five had no osteonecrosis (controls)...
January 21, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28097114/bilateral-idiopathic-chondrolysis-of-the-hip-in-an-adult-a-case-report-and-review-of-the-literature
#11
Kyoung-Ho Moon, Eun-Ho Shin, Joon-Soon Kang
Idiopathic chondrolysis of the hip usually develops in adolescents and is a disease characterized by gradual degenerative changes of the hyaline cartilage surrounding the head of the femur. It eventually decreases the hip joint space and causes limitations in the hip joint range of motion due to pain. The authors had experienced an unusual case of bilateral idiopathic chondrolysis of the hip in an 54 year-old male; thus, we report the treatment results and literature reviews in this case report.
December 2016: Hip & Pelvis
https://www.readbyqxmd.com/read/28090448/quantitative-techniques-for-musculoskeletal-mri-at-7-tesla
#12
REVIEW
Neal K Bangerter, Meredith D Taylor, Grayson J Tarbox, Antony J Palmer, Daniel J Park
Whole-body 7 Tesla MRI scanners have been approved solely for research since they appeared on the market over 10 years ago, but may soon be approved for selected clinical neurological and musculoskeletal applications in both the EU and the United States. There has been considerable research work on musculoskeletal applications at 7 Tesla over the past decade, including techniques for ultra-high resolution morphological imaging, 3D T2 and T2* mapping, ultra-short TE applications, diffusion tensor imaging of cartilage, and several techniques for assessing proteoglycan content in cartilage...
December 2016: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/28088837/disease-severity-classification-using-quantitative-magnetic-resonance-imaging-data-of-cartilage-in-femoroacetabular-impingement
#13
Lisa L Henn, John Hughes, Eleena Iisakka, Jutta Ellermann, Shabnam Mortazavi, Connor Ziegler, Mikko J Nissi, Patrick Morgan
Femoroacetabular impingement (FAI) is a condition in which subtle deformities of the femoral head and acetabulum (hip socket) result in pathological abutment during hip motion. FAI is a common cause of hip pain and can lead to acetabular cartilage damage and osteoarthritis. For some patients with FAI, surgical intervention is indicated, and it can improve quality of life and potentially delay the onset of osteoarthritis. For other patients, however, surgery is contraindicated because significant cartilage damage has already occurred...
January 15, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/28086918/atypical-monoarthritis-presentation-in-children-with-oligoarticular-juvenile-idiopathic-arthritis-a-case-series
#14
Natasha Lepore, Megan Cashin, Debra Bartley, Daniela Simona Ardelean
BACKGROUND: Oligoarticular juvenile idiopathic arthritis (oligoJIA), the most common chronic inflammatory arthritis of childhood, usually involves the knees and ankles. Severe oligoJIA monoarthritis presenting in a joint other than knees and ankles, is rare. FINDINGS: We report four children who presented with severe isolated arthritis of the hip, wrist or elbow and were diagnosed with oligoJIA. All four were girls with a median age of 11.5 years. Those with hip arthritis also met the classification criteria for juvenile-onset spondylarthopathy...
January 13, 2017: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/28066741/cell-therapy-for-cartilage-defects-of-the-hip
#15
Rodrigo Mardones, Alessio Giai Via, Claudio Jofré, José Minguell, Claudio Rodriguez, Alexander Tomic, Matias Salineros
BACKGROUND: Chondral injuries are commonly related to poor clinical outcome, but recent data showed some improvements in function and pain after hip arthroscopy. Cell-based therapies represent an appealing alternative strategy for cartilage regeneration, and interesting results have been recently reported after intra-articular injections of mesenchymal stem cells (MSCs). The results of hip arthroscopy for femoroacetabular impingement (FAI) and intra-articular injections of autologous expanded bone marrow - MSCs (BM-MSCs) are reported in this retrospective study...
July 2016: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/28057012/clinical-results-of-arthroscopic-surgery-in-patients-over-50%C3%A2-years-of-age-what-viability-does-it-have-as-a-joint-preservative-surgery
#16
Mitsutoshi Moriya, Kensuke Fukushima, Katsufumi Uchiyama, Naonobu Takahira, Takeaki Yamamoto, Yojiro Minegishi, Masashi Takaso
BACKGROUND: To identify whether hip arthroscopy is a suitable option for treating hip pain in elderly patients and investigate the clinical outcomes of hip arthroscopic surgery for labrum tear and/or osteoarthritis in patients over 50 years of age. METHODS: Between August 2009 and May 2014, a series of 23 patients (6 men and 17 women) with a mean age of 59 years underwent arthroscopy. We retrospectively examined the clinical records, radiographs, and outcome questionnaires from all patients...
January 6, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/28053252/instability-of-the-hip-after-anatomical-re-alignment-in-patients-with-a-slipped-capital-femoral-epiphysis
#17
REVIEW
A Aprato, M Leunig, A Massé, T Slongo, R Ganz
AIMS: Several studies have reported the safety and efficacy of subcapital re-alignment for patients with slipped capital femoral epiphysis (SCFE) using surgical dislocation of the hip and an extended retinacular flap. Instability of the hip and dislocation as a consequence of this surgery has only recently gained attention. We discuss this problem with some illustrative cases. MATERIALS AND METHODS: We explored the literature on the possible pathophysiological causes and surgical steps associated with the risk of post-operative instability and articular damage...
January 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/28050531/femoroacetabular-impingement
#18
REVIEW
José Batista Volpon
The femoroacetabular impingement (FAI) is as condition recently characterized that results from the abnormal anatomic and functional relation between the proximal femur and the acetabular border, associated with repetitive movements, which lead labrum and acetabular cartilage injuries. Such alterations result from anatomical variations such as acetabular retroversion or decrease of the femoroacetabular offset. In addition, FAI may result from acquired conditions as malunited femoral neck fractures, or retroverted acetabulum after pelvic osteotomies...
November 2016: Revista Brasileira de Ortopedia
https://www.readbyqxmd.com/read/28041611/the-mechanics-of-focal-chondral-defects-in-the-hip
#19
Brenden J Klennert, Benjamin J Ellis, Travis G Maak, Ashley L Kapron, Jeffrey A Weiss
There is a mean incidence of osteoarthritis (OA) of the hip in 8% of the overall population. In the presence of focal chondral defects, defined as localized damage to the articular cartilage, there is an increased risk of symptomatic progression toward OA. This relationship between chondral defects and subsequent development of OA has led to substantial efforts to develop effective procedures for surgical cartilage repair. This study examined the effects of chondral defects and labral delamination on cartilage mechanics in the dysplastic hip during the gait cycle using subject-specific finite element analysis...
November 29, 2016: Journal of Biomechanics
https://www.readbyqxmd.com/read/28035445/effect-of-progressive-high-impact-exercise-on-femoral-neck-structural-strength-in-postmenopausal-women-with-mild-knee-osteoarthritis-a-12-month-rct
#20
J Multanen, T Rantalainen, H Kautiainen, R Ahola, T Jämsä, M T Nieminen, E Lammentausta, A Häkkinen, I Kiviranta, A Heinonen
: It is uncertain whether subjects with mild knee osteoarthritis, and who may be at risk of osteoporosis, can exercise safely with the aim of improving hip bone strength. This RCT showed that participating in a high-impact exercise program improved femoral neck strength without any detrimental effects on knee cartilage composition. INTRODUCTION: No previous studies have examined whether high-impact exercise can improve bone strength and articular cartilage quality in subjects with mild knee osteoarthritis...
December 29, 2016: Osteoporosis International
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