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https://www.readbyqxmd.com/read/28547137/age-dependent-arthrosonographic-reference-values-of-the-hip-joint-in-healthy-children-and-adolescents-a-cross-sectional-multicenter-ultrasound-study
#1
Ralf Felix Trauzeddel, Hartwig Lehmann, Daniel Windschall, Gerd Ganser, Rainer Berendes, Maria Haller, Manuela Krumrey-Langkammerer, Katharina Palm-Beden, Antje Nimtz-Talaska, Christine Nirschl, Phillip Schoof, Ralf Trauzeddel
BACKGROUND: Musculoskeletal US is a noninvasive imaging method for diagnosing and monitoring inflammatory rheumatic diseases. OBJECTIVES: To develop age- and gender-related arthrosonographic reference intervals for the hip joint of healthy children and adolescents. MATERIALS AND METHODS: In a cross-sectional US study, we examined both hip joints of 445 children and adolescents with an age range of 1 year to 18 years. We measured the distance between the bone surface and the outer margin of the joint capsule to define the bone-capsule distance, the joint capsule and cartilage thickness, and the capsule layer thickness...
May 25, 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/28530031/celecoxib-for-osteoarthritis
#2
REVIEW
Livia Puljak, Ana Marin, Davorka Vrdoljak, Filipa Markotic, Ana Utrobicic, Peter Tugwell
BACKGROUND: Osteoarthritis (OA) is the most common form of arthritis and is caused by degeneration of the joint cartilage and growth of new bone, cartilage and connective tissue. It is often associated with major disability and impaired quality of life. There is currently no consensus on the best treatment to improve OA symptoms. Celecoxib is a selective non-steroidal anti-inflammatory drug (NSAID). OBJECTIVES: To assess the clinical benefits (pain, function, quality of life) and safety (withdrawals due to adverse effects, serious adverse effects, overall discontinuation rates) of celecoxib in osteoarthritis (OA)...
May 22, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28529662/femoral-and-acetabular-re-alignment-in-slipped-capital-femoral-epiphysis
#3
M Leunig, H M Manner, L Turchetto, R Ganz
NEW PATHOPHYSIOLOGICAL INSIGHTS: Based on improved knowledge of the vascular supply of the proximal femur, a safe surgical dislocation of the hip joint was established allowing direct insights to the pathomorphological malfunctioning of the joint. One insight was that slipped capital femoral epiphysis (SCFE) impingement leads to substantial damage of the chondrolabral rim area, even in the presence of minor slips. A further surgical development was the extended retinacular flap allowing for correction of the deformity with calculable risk for iatrogenic necrosis...
April 2017: Journal of Children's Orthopaedics
https://www.readbyqxmd.com/read/28529661/slipped-capital-femoral-epiphysis-management-and-the-arthroscope
#4
F Accadbled, O May, C Thévenin-Lemoine, J Sales de Gauzy
BACKGROUND: In situ pinning of slipped capital femoral epiphysis (SCFE) results in various degrees of deformity of the femoral head-neck junction. Repetitive trauma from cam-type femoroacetabular impingement (FAI) can lead to labral tears and injury to the articular cartilage causing loss of function. Arthroscopic osteoplasty is an alternative to open procedure and to Southwick/Imhäuser-type osteotomies in symptomatic selected cases. SURGICAL TECHNIQUE: The amount of bone to be resected has to be carefully planned pre-operatively...
April 2017: Journal of Children's Orthopaedics
https://www.readbyqxmd.com/read/28521839/associations-between-systemic-bone-mineral-density-and-early-knee-cartilage-changes-in-middle-aged-adults-without-clinical-knee-disease-a-prospective-cohort-study
#5
Andrew J Teichtahl, Yuanyuan Wang, Anita E Wluka, Boyd J Strauss, Joseph Proietto, John B Dixon, Graeme Jones, Flavia M Cicuttini
BACKGROUND: Osteoarthritis has a high prevalence in people with high bone mineral density (BMD). Nevertheless, whether high systemic BMD predates early structural features of knee osteoarthritis is unclear. This study examined the association between systemic BMD and knee cartilage defect progression and cartilage volume loss in middle-aged people without clinical knee disease. METHODS: Adults (n = 153) aged 25-60 years had total body, lumbar spine, and total hip BMD assessed by dual-energy X-ray absorptiometry at baseline (2005-2008), and tibial cartilage volume and tibiofemoral cartilage defects assessed by magnetic resonance imaging at baseline and follow up (2008-2010)...
May 18, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28506842/diagnostic-and-prognostic-value-of-delayed-gadolinium-enhanced-magnetic-resonance-imaging-of-cartilage-dgemric-in-early-osteoarthritis-of-the-hip
#6
Antony Palmer, Scott Fernquest, Ines Rombach, Daniel Park, Tom Pollard, John Broomfield, Neal Bangerter, Andrew Carr, Sion Glyn-Jones
BACKGROUND: Delayed Gadolinium Enhanced MRI of Cartilage (dGEMRIC) can detect glycosaminoglycan loss in the acetabular cartilage of asymptomatic individuals with cam morphology. The aims of this study were to explore the relationship between cam morphology and dGEMRIC values, and to explore whether baseline dGEMRIC can predict the development of radiographic hip osteoarthritis. METHODS: Prospective cohort (SibKids) study with clinical, radiographic, and MRI assessment at baseline and five-year follow-up (n=34)...
May 12, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28500828/the-impact-of-thyroid-autoimmunity-tpoab-on-bone-density-and-fracture-risk-in-postmenopausal-women
#7
Snezana P Polovina, Dragana Miljic, Sladjana Zivojinovic, Natasa Milic, Dragan Micic, Vera Popovic Brkic
OBJECTIVE: Skeletal development, linear growth, cartilage biology and bone turnover are highly dependent on the activity of thyroid hormones. Thyroid dysfunction affects the skeleton, and autoimmune thyroid disease, manifesting as a chronic inflammatory condition, may be an important contributing factor to impaired bone quality in these patients. MATERIALS AND METHODS: Measurement of TSH, FT4, TPOAb and bone mineral density and FRAX score calculations were performed in 189 postmenopausal women (110 euthyroid women and 79 women diagnosed with subclinical hypothyroidism) divided into subgroups according to the presence of TPOAb...
January 2017: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28474620/bone-marrow-extract-as-a-growth-supplement-for-human-iliac-apophyseal-chondrocyte-culture
#8
Balasubramanian Balakumar, Karthikeyan Rajagopal, Vrisha Madhuri
BACKGROUND & OBJECTIVES: Human bone marrow is rich in various growth factors which may support the chondrocyte growth. This study was conducted to compare the culture characteristics of human growth plate chondrocyte in foetal bovine serum (FBS) and human autologous bone marrow extract (BME) in monolayer culture. METHODS: Iliac crest apophyseal cartilage was harvested from four donors, aged between two and nine years, undergoing hip surgery. Chondrocytes were propagated under two culture conditions, with 10 per cent FBS and 10 per cent autologous BME harvested from the same donors...
December 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/28474284/damage-associated-molecular-patterns-in-the-pathogenesis-of-osteoarthritis-potentially-novel-therapeutic-targets
#9
REVIEW
John H Rosenberg, Vikrant Rai, Matthew F Dilisio, Devendra K Agrawal
Osteoarthritis (OA) is a chronic disease that degrades the joints and is often associated with increasing age and obesity. The two most common sites of OA in adults are the knee and hip joints. Increased mechanical stress on the joint from obesity can cause the articular cartilage to degrade and release damage-associated molecular patterns (DAMPs). These DAMPs are involved in various molecular pathways that interact with nuclear factor-kappa B and result in the transcription of inflammatory cytokines and activation of matrix metalloproteinases that progressively destroy cartilage...
May 4, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28466651/t2-mapping-of-the-hip-in-asymptomatic-volunteers-with-normal-cartilage-morphology-an-analysis-of-regional-and-age-dependent-distribution
#10
Tobias Hesper, Christoph Schleich, Alexander Buchwald, Harish S Hosalkar, Gerald Antoch, Rüdiger Krauspe, Christoph Zilkens, Bernd Bittersohl
Objective To assess age-dependent and regional differences in T2* relaxation measurements in hip joint cartilage of asymptomatic volunteers at 3 T. Design Three age cohorts (cohort 1: age 20-30 years, 15 individuals; cohort 2: age 30-40 years, 17 individuals; cohort 3: age 40-50 years, 15 individuals) were enrolled. T2* values were obtained in the central and peripheral cartilage of the acetabulum and the femoral head in 7 regions (anterior to superior and posterior). Results T2* did not differ among age cohorts in acetabular cartilage (cohort 1: 24...
December 1, 2016: Cartilage
https://www.readbyqxmd.com/read/28466650/t2-mapping-for-hip-joint-cartilage-assessment-pre-mri-exercise-and-time-of-imaging-do-not-bias-the-t2-measurement-in-asymptomatic-volunteers
#11
Tobias Hesper, Harish S Hosalkar, Christoph Schleich, Gerald Antoch, Götz H Welsch, Rüdiger Krauspe, Christoph Zilkens, Bernd Bittersohl
Objective To identify if the time of day and pre-imaging exercise matter while performing T2* mapping of hip joint cartilage at 3 T. Design Nine asymptomatic healthy volunteers (mean age 27.4 ± 4.0 years) with no obvious morphological evidence of cartilage damage were enrolled. The MRI protocol included a double-echo steady state (DESS) sequence for morphological cartilage assessment and a multi-echo data image combination sequence for the T2* measurement. T2* values were obtained between 8 and 11 a.m., between 3 and 6 p...
August 1, 2016: Cartilage
https://www.readbyqxmd.com/read/28466104/imaging-evaluation-of-the-hip-after-arthroscopic-surgery-for-femoroacetabular-impingement
#12
REVIEW
Julia Crim
Arthroscopic surgery for femoroacetabular impingement (FAI) is increasingly frequently performed. Initial reports were that complications were very low, but as experience has increased, a number of long-term complications, in addition to factors related to poor clinical outcomes, have been identified. This review describes the normal and abnormal postoperative imaging appearance of the hip after arthroscopy for FAI. Abnormalities discussed include incomplete resection or over-resection of the impingement lesion, heterotopic ossification, cartilage damage, chondrolysis, instability and dislocation, recurrent labral tear, adhesions, psoas atrophy, infection, and avascular necrosis...
May 2, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28448087/effect-of-a-mediterranean-type-diet-on-inflammatory-and-cartilage-degradation-biomarkers-in-patients-with-osteoarthritis
#13
J Dyer, G Davison, S M Marcora, A R Mauger
OBJECTIVES: To investigate the effects of a Mediterranean type diet on patients with osteoarthritis (OA). PARTICIPANTS: Ninety-nine volunteers with OA (aged 31 - 90 years) completed the study (83% female). SETTING: Southeast of England, UK. DESIGN: Participants were randomly allocated to the dietary intervention (DIET, n = 50) or control (CON, n = 49). The DIET group were asked to follow a Mediterranean type diet for 16 weeks whereas the CON group were asked to follow their normal diet...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/28432505/3d-double-echo-steady-state-sequence-assessment-of-hip-joint-cartilage-and-labrum-at-3-tesla-comparative-analysis-of-magnetic-resonance-imaging-and-intraoperative-data
#14
Christoph Schleich, Tobias Hesper, Harish S Hosalkar, Fanni Rettegi, Christoph Zilkens, Rüdiger Krauspe, Gerald Antoch, Bernd Bittersohl
OBJECTIVES: To assess the diagnostic accuracy of a high-resolution, three-dimensional (3D) double-echo steady-state (DESS) sequence with radial imaging at 3 Tesla (T) for evaluating cartilage and labral alterations in the hip. METHODS: Magnetic resonance imaging (MRI) data obtained at 3 T, including radially reformatted DESS images and intraoperative data of 45 patients (mean age 42 ± 13.7 years) who underwent hip arthroscopy, were compared. The acetabular cartilage and labrum of the upper hemisphere of the acetabulum and the central femoral head cartilage were evaluated...
April 21, 2017: European Radiology
https://www.readbyqxmd.com/read/28421358/vitamin-d-supplementation-for-the-management-of-knee-osteoarthritis-a-systematic-review-of-randomized-controlled-trials
#15
Salman Hussain, Ambrish Singh, Mohd Akhtar, Abul Kalam Najmi
Conflicting evidence exists concerning the supplementation of vitamin D in knee osteoarthritis condition. This systematic literature review was done to explore the effects of vitamin D supplementation in the management of knee osteoarthritis. Electronic literature search was done in databases like PubMed(®), Embase(®), and Cochrane CENTRAL from inception to 6th July 2016. The quality of included Randomized Controlled Trials (RCTs) was assessed using Cochrane risk of bias tool. We considered change in Western Ontario and McMaster Universities (WOMAC) index, Visual Analog Scale (VAS) and Functional Pain Score (FPS) as the primary outcome measure...
April 18, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28405471/mri-based-hip-cartilage-measures-in-osteoarthritic-and-non-osteoarthritic-individuals-a-systematic-review
#16
REVIEW
Hector N Aguilar, Michele C Battié, Jacob L Jaremko
Osteoarthritis is a common hip joint disease, involving loss of articular cartilage. The prevalence and prognosis of hip osteoarthritis have been difficult to determine, with various clinical and radiological methods used to derive epidemiological estimates exhibiting significant heterogeneity. MRI-based methods directly visualise hip joint cartilage, and offer potential to more reliably define presence and severity of osteoarthritis, but have been underused. We performed a systematic review of MRI-based estimates of hip articular cartilage in the general population and in patients with established osteoarthritis, using MEDLINE, EMBASE and SCOPUS current to June 2016, with search terms such as 'hip', 'femoral head', 'cartilage', 'volume', 'thickness', 'MRI', etc...
2017: RMD Open
https://www.readbyqxmd.com/read/28399156/presence-of-il-17-in-synovial-fluid-identifies-a-potential-inflammatory-osteoarthritic-phenotype
#17
Sarah J B Snelling, Sylvette Bas, Gabor J Puskas, Stephanie G Dakin, Domizio Suva, Axel Finckh, Cem Gabay, Pierre Hoffmeyer, Andrew J Carr, Anne Lübbeke
PURPOSE: Osteoarthritis (OA) is a common and heterogeneous arthritic disorder. Patients suffer pain and their joints are characterized by articular cartilage loss and osteophyte formation. Risk factors for OA include age and obesity with inflammation identified as a key mediator of disease pathogenesis. Interleukin-17A (IL-17) is a pro-inflammatory cytokine that has been implicated in inflammatory diseases such as rheumatoid arthritis. IL-17 can upregulate expression of inflammatory cytokines and adipocytokines...
2017: PloS One
https://www.readbyqxmd.com/read/28385001/comparative-kinematic-gait-analysis-in-young-and-old-beagle-dogs
#18
Malin Lorke, Maray Willen, Karin Lucas, Martin Beyerbach, Patrick Wefstaedt, Hugo Murua Escobar, Ingo Nolte
Age-related involution in dogs involves loss of muscle mass and changes in connective tissue and articular cartilage. The aim of this study was to examine whether an age-related influence on joint mobility can be detected in the absence of diseases. Five young (Ø 2.0 years) and five old (Ø 10.4 years) healthy and sound Beagle dogs were measured during locomotion on a treadmill by computer-assisted gait analysis. Angles of the shoulder, elbow, carpal, hip, stifle and tarsal joints were analyzed, including joint angle progression curves, minimum and maximum joint angles and range of motion (ROM)...
April 6, 2017: Journal of Veterinary Science
https://www.readbyqxmd.com/read/28384153/cartilage-formation-in-the-pelvic-skeleton-during-the-embryonic-and-early-fetal-period
#19
Misaki Okumura, Aoi Ishikawa, Tomoki Aoyama, Shigehito Yamada, Chigako Uwabe, Hirohiko Imai, Tetsuya Matsuda, Akio Yoneyama, Tohoru Takeda, Tetsuya Takakuwa
The pelvic skeleton is formed via endochondral ossification. However, it is not known how the normal cartilage is formed before ossification occurs. Furthermore, the overall timeline of cartilage formation and the morphology of the cartilage in the pelvis are unclear. In this study, cartilage formation in the pelvic skeletons of 25 human fetuses (crown-rump length [CRL] = 11.9-75.0 mm) was observed using phase-contrast computed tomography and 7T magnetic resonance imaging. The chondrification center of the ilium, ischium, and pubis first appeared simultaneously at Carnegie stage (CS) 18, was located around the acetabulum, and grew radially in the later stage...
2017: PloS One
https://www.readbyqxmd.com/read/28379908/effects-of-long-term-high-load-exercise-on-the-anatomy-of-the-hip-joints-a-preliminary-report
#20
Yawei Song, Xiyuan Zhang, Ke Rong
The aim of this study was to assess the impact of different sports on hip joint anatomic parameters in athletes. This was a cross-sectional study of eight male trampolinists, eight male weightlifters, and eight male volunteers enrolled in July 2014. Hip joint anatomic parameters were measured from plain radiographs taken at the level of the lesser trochanter center. Data were compared between groups using the χ-test or one-way analysis of variance with the Bonferroni post-hoc test. There were no significant differences among groups in age, height, or weight...
April 4, 2017: Journal of Pediatric Orthopedics. Part B
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