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https://www.readbyqxmd.com/read/28638837/validation-of-a-novel-immunoline-assay-for-patient-stratification-according-to-virulence-of-the-infecting-helicobacter-pylori-strain-and-eradication-status
#1
Luca Formichella, Laura Romberg, Hannelore Meyer, Christian Bolz, Michael Vieth, Michael Geppert, Gereon Göttner, Christina Nölting, Wolfgang Schepp, Arne Schneider, Kurt Ulm, Petra Wolf, Ingrid Lisanne Holster, Ernst J Kuipers, Bernd Birkner, Erwin Soutschek, Markus Gerhard
Helicobacter pylori infection shows a worldwide prevalence of around 50%. However, only a minority of infected individuals develop clinical symptoms or diseases. The presence of H. pylori virulence factors, such as CagA and VacA, has been associated with disease development, but assessment of virulence factor presence requires gastric biopsies. Here, we evaluate the H. pylori recomLine test for risk stratification of infected patients by comparing the test score and immune recognition of type I or type II strains defined by the virulence factors CagA, VacA, GroEL, UreA, HcpC, and gGT with patient's disease status according to histology...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28637876/monocyte-derived-dendritic-cells-with-silenced-pd-1-ligands-and-transpresenting-interleukin-15-stimulate-strong-tumor-reactive-t-cell-expansion
#2
Johan Mj Van den Bergh, Evelien Ljm Smits, Zwi N Berneman, Tim Ja Hutten, Hans De Reu, Viggo Fi Van Tendeloo, Harry Dolstra, Eva Lion, Willemijn Hobo
Although allogeneic stem cell transplantation (allo-SCT) can elicit graft-versus-tumor (GVT) immunity, patients often relapse due to residual tumor cells. As essential orchestrators of the immune system, vaccination with dendritic cells (DCs) is an appealing strategy to boost the GVT-response. Nevertheless, durable clinical responses after DC vaccination are still limited, stressing the need to improve current DC vaccines. Aiming to empower DC potency, we engineered monocyte-derived DCs to deprive them of ligands for the immune checkpoint regulated by programmed death 1 (PD-1)...
June 21, 2017: Cancer Immunology Research
https://www.readbyqxmd.com/read/28633071/structural-characterization-of-the-immunostimulatory-exopolysaccharide-produced-by-leuconostoc-mesenteroides-strain-ntm048
#3
Chiaki Matsuzaki, Chikahiro Takagaki, Yusuke Tomabechi, Lennart S Forsberg, Christian Heiss, Parastoo Azadi, Kenji Matsumoto, Toshihiko Katoh, Koji Hosomi, Jun Kunisawa, Kenji Yamamoto, Keiko Hisa
The exopolysaccharide (EPS) produced by probiotic Leuconostoc mesenteroides subsp. mesenteroides strain NTM048 has been reported to be an immunostimulant that enhances mucosal IgA production. In this study, we found that intranasal administration of mice with the EPS and an antigen (ovalbumin) resulted in secretion of antigen-specific IgA and IgG in the airway mucosa and the serum, suggesting that the EPS has the adjuvant activity for use with mucosal vaccination. Methylation analysis coupled to GC-MS, and 1D and 2D NMR spectroscopy revealed that 94% of the EPS consists of an α-(1 → 6) glucan containing 4% of 1→3-linked α-glucose branches...
June 15, 2017: Carbohydrate Research
https://www.readbyqxmd.com/read/28626952/multivariate-binary-classification-of-imbalanced-datasets-a-case-study-based-on-high-dimensional-multiplex-autoimmune-assay-data
#4
Laura Schlieker, Anna Telaar, Angelika Lueking, Peter Schulz-Knappe, Carmen Theek, Katja Ickstadt
The classification of a population by a specific trait is a major task in medicine, for example when in a diagnostic setting groups of patients with specific diseases are identified, but also when in predictive medicine a group of patients is classified into specific disease severity classes that might profit from different treatments. When the sizes of those subgroups become small, for example in rare diseases, imbalances between the classes are more the rule than the exception and make statistical classification problematic when the error rate of the minority class is high...
June 19, 2017: Biometrical Journal. Biometrische Zeitschrift
https://www.readbyqxmd.com/read/28620645/alloimmunity-but-not-viral-immunity-promotes-allograft-loss-in-a-mouse-model-of-polyomavirus-associated-allograft-injury
#5
Steven C Kim, Jun Wang, Ying Dong, David V Mathews, Joshua A Albrecht, Cynthia P Breeden, Alton B Farris, Aron E Lukacher, Mandy L Ford, Kenneth A Newell, Andrew B Adams
BACKGROUND: The interplay between viral infection and alloimmunity is known to influence the fate of transplanted organs. Clarifying how local virus-associated inflammation/injury and antiviral immunity can alter host alloimmune responses in transplantation remains a critical question. METHODS: We used a mouse model of polyomavirus (PyV) infection and kidney transplantation to investigate the roles of direct viral pathology, the antiviral immune response, and alloimmunity in the pathogenesis of PyV-associated allograft injury...
June 2017: Transplantation Direct
https://www.readbyqxmd.com/read/28620373/mechanisms-of-autoantibody-induced-pathology
#6
REVIEW
Ralf J Ludwig, Karen Vanhoorelbeke, Frank Leypoldt, Ziya Kaya, Katja Bieber, Sandra M McLachlan, Lars Komorowski, Jie Luo, Otavio Cabral-Marques, Christoph M Hammers, Jon M Lindstrom, Peter Lamprecht, Andrea Fischer, Gabriela Riemekasten, Claudia Tersteeg, Peter Sondermann, Basil Rapoport, Klaus-Peter Wandinger, Christian Probst, Asmaa El Beidaq, Enno Schmidt, Alan Verkman, Rudolf A Manz, Falk Nimmerjahn
Autoantibodies are frequently observed in healthy individuals. In a minority of these individuals, they lead to manifestation of autoimmune diseases, such as rheumatoid arthritis or Graves' disease. Overall, more than 2.5% of the population is affected by autoantibody-driven autoimmune disease. Pathways leading to autoantibody-induced pathology greatly differ among different diseases, and autoantibodies directed against the same antigen, depending on the targeted epitope, can have diverse effects. To foster knowledge in autoantibody-induced pathology and to encourage development of urgently needed novel therapeutic strategies, we here categorized autoantibodies according to their effects...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28614781/cell-lines-generated-from-a-chronic-lymphocytic-leukemia-mouse-model-exhibit-constitutive-btk-and-akt-signaling
#7
Simar Pal Singh, Saravanan Y Pillai, Marjolein J W de Bruijn, Ralph Stadhouders, Odilia B J Corneth, Henk Jan van den Ham, Alice Muggen, Wilfred van IJcken, Erik Slinger, Annemieke Kuil, Marcel Spaargaren, Arnon P Kater, Anton W Langerak, Rudi W Hendriks
Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of mature CD5+ B cells in blood. Spontaneous apoptosis of CLL cells in vitro has hampered in-depth investigation of CLL pathogenesis. Here we describe the generation of three monoclonal mouse cell lines, EMC2, EMC4 and EMC6, from the IgH.TEμ CLL mouse model based on sporadic expression of SV40 large T antigen. The cell lines exhibit a stable CD5+CD43+IgM+CD19+ CLL phenotype in culture and can be adoptively transferred into Rag1-/- mice...
May 26, 2017: Oncotarget
https://www.readbyqxmd.com/read/28610739/histologic-and-immunohistochemical-identification-of-cribriform-adenocarcinoma
#8
Rashidah Wiley, Aditya Kalgi, Renee Reich, Paul Freedman
OBJECTIVE: To assess whether tumors originally classified as adenocarcinoma not otherwise specified (Adca-NOS), adenoid cystic carcinoma (ACC), and polymorphous low-grade adenocarcinoma (PLGA) could be reclassified as cribriform adenocarcinoma of the tongue and minor salivary gland (CATMSG). STUDY DESIGN: Tumors diagnosed between 1992 and 2014 at Oral Pathology Laboratory, Inc. (New York Presbyterian Hospital) were selected. Each tumor was reviewed by 3 oral pathologists to confirm the diagnosis of CATMSG...
July 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/28607544/analysis-of-fascin-1-in-relation-to-gleason-risk-classification-and-nuclear-ets-related-gene-status-of-human-prostate-carcinomas-an-immunohistochemical-study-of-clinically-annotated-tumours-from-the-wales-cancer-bank
#9
Matthew T Jefferies, Christopher S Pope, Howard G Kynaston, Alan R Clarke, Richard M Martin, Josephine C Adams
Although prostate-specific antigen (PSA) testing can identify early-stage prostate cancers, additional biomarkers are needed for risk stratification. In one study, high levels of the actin-bundling protein, fascin-1, were correlated with lethal-phase, hormone-refractory prostate cancer. Analyses of independent samples are needed to establish the value of fascin-1 as a possible biomarker. We examined fascin-1 by immunohistochemistry in tumour specimens from the Wales Cancer Bank in comparison with nuclear-located ETS-related gene (ERG), an emerging marker for aggressive prostate cancer...
2017: Biomarkers in Cancer
https://www.readbyqxmd.com/read/28592422/association-of-sex-with-risk-of-kidney-graft-failure-differs-by-age
#10
Fanny Lepeytre, Mourad Dahhou, Xun Zhang, Julie Boucquemont, Ruth Sapir-Pichhadze, Heloise Cardinal, Bethany J Foster
Prior studies of sex differences in kidney graft survival showed conflicting results. We hypothesized that the association between recipient sex and kidney graft failure risk differs by recipient age and donor sex. We evaluated 159,417 patients recorded in the Scientific Registry of Transplant Recipients database who received a first deceased-donor kidney transplant (1995-2013). We used time-varying Cox models to estimate the association between recipient sex and death-censored graft failure. Models, stratified on donor sex and adjusted for potential confounders, included a recipient sex by current age interaction term...
June 7, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28591309/detection-and-molecular-characterisation-of-a-diagnosis-escape-variant-associated-with-occult-hepatitis-b-virus-in-brazil
#11
Ricardo Wagner de Almeida, Francisco Campello do Amaral Mello, Isabelle Vasconcelos Menegoy, Márcia Paschoal do Espírito Santo, Cléber Ferreira Ginuíno, Paulo Sérgio Fonseca de Sousa, Livia Melo Villar, Elisabeth Lampe, Lia Laura Lewis-Ximenez
BACKGROUND: Many studies have identified mutations in the hepatitis B surface antigen (HBsAg) as important factors limiting the ability of commercial serological assays to detect this viral antigen. However, an association between mutations in the HBsAg gene and the occurrence of occult HBV infection (OBI) in patients has not been established. OBJECTIVES: To detect hepatitis B virus (HBV) DNA in patients with anti-HBc as a unique serological marker, a previously published, cost-effective TaqMan-based real-time polymerase chain reaction (PCR) test with minor groove binding probes was adapted for use in this study...
July 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28589078/recent-clinical-trials-of-cancer-immunogene-therapy-in-companion-animals
#12
REVIEW
Liliana M E Finocchiaro, Gerardo C Glikin
This mini-review presents the results of veterinary clinical trials on immunogene therapy published from 2014 to 2016. A variety of tumors, among them melanoma (canine and equine), mastocytoma (canine), mammary adenocarcinoma (canine) and fibrosarcoma (feline) were treated by using diverse strategies. Non-viral vectors were usually employed to transfer genes of cytokines, suicide enzymes and/or tumor associated antigens. In general terms, minor or no adverse collateral effects were related to these procedures, and treated patients frequently improved their conditions (better quality of life, delayed or suppressed recurrence or metastatic spread, increased survival)...
May 20, 2017: World Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28582644/no-prolongation-of-skin-allograft-survival-by-immunoproteasome-inhibition-in-mice
#13
Sarah Mundt, Michael Basler, Birgit Sawitzki, Marcus Groettrup
The immunoproteasome, a distinct class of proteasomes, which is inducible under inflammatory conditions and constitutively expressed in monocytes and lymphocytes, is known to shape the antigenic repertoire presented on major histocompatibility complex (MHC) class I molecules. Moreover, inhibition of the immunoproteasome subunit LMP7 ameliorates clinical symptoms of autoimmune diseases in vivo and was shown to suppress the development of T helper cell (Th) 1 and Th17 cells and to promote regulatory T-cell (Treg) generation independently of its function in antigen processing...
June 2, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/28581468/a-phase-i-ii-minor-histocompatibility-antigen-loaded-dendritic-cell-vaccination-trial-to-safely-improve-the-efficacy-of-donor-lymphocyte-infusions-in-myeloma
#14
L E Franssen, M W H Roeven, W Hobo, R Doorn, R Oostvogels, J H F Falkenburg, N W van de Donk, M G D Kester, H Fredrix, K Westinga, I Slaper-Cortenbach, E Spierings, M J Kersten, H Dolstra, T Mutis, N Schaap, H M Lokhorst
Allogeneic stem cell transplantation (allo-SCT) with or without donor lymphocyte infusions (DLI) is the only curative option for several hematological malignancies. Unfortunately, allo-SCT is often associated with GvHD, and patients often relapse. We therefore aim to improve the graft-versus-tumor effect, without increasing the risk of GvHD, by targeting hematopoietic lineage-restricted and tumor-associated minor histocompatibility antigens using peptide-loaded dendritic cell (DC) vaccinations. In the present multicenter study, we report the feasibility, safety and efficacy of this concept...
June 5, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28573192/modeling-the-effect-of-the-aryl-hydrocarbon-receptor-on-transplant-immunity
#15
Walker Julliard, John H Fechner, Leah Owens, Chelsea A O'Driscoll, Ling Zhou, Jeremy A Sullivan, Lynn Frydrych, Amanda Mueller, Joshua D Mezrich
BACKGROUND: Exposure to pollutants through inhalation is a risk factor for lung diseases including cancer, asthma, and lung transplant rejection, but knowledge of the effects of inhaled pollutants on pathologies outside of the lung is limited. METHODS: Using the minor-mismatched model of male C57BL/6J (B6) to female B6 skin grafts, recipient mice were treated with an inhaled urban dust particle sample every 3 days before and after grafting. Graft survival time was determined, and analysis of the resulting immune response was performed at time before rejection...
May 2017: Transplantation Direct
https://www.readbyqxmd.com/read/28571291/membranous-basal-cell-adenoma-a-rare-entity-in-an-unusual-location
#16
Nadeem Jeddy, Lakshmipathy Prasannamoorthy, Rooban Thavarajah, T Radhika, Aarthi Ramachandran
Basal cell adenoma is a rare benign salivary gland neoplasm exhibiting an isomorphic basaloid tumour cell pattern, commonly occurring in the parotid. Membranous variant warrants separate consideration because of its recurrence and rate of malignant transformation. We report a case of membranous type basal cell adenoma occurring in minor salivary gland in a 61-year-old female patient. The histopathological diagnosis was supported by immunohistochemical analysis and serum Carcinoembryonic antigen level.
April 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28562582/the-b-cell-receptor-controls-fitness-of-myc-driven-lymphoma-cells-via-gsk3%C3%AE-inhibition
#17
Gabriele Varano, Simon Raffel, Martina Sormani, Federica Zanardi, Silvia Lonardi, Christin Zasada, Laura Perucho, Valentina Petrocelli, Andrea Haake, Albert K Lee, Mattia Bugatti, Ulrike Paul, Eelco Van Anken, Laura Pasqualucci, Raul Rabadan, Reiner Siebert, Stefan Kempa, Maurilio Ponzoni, Fabio Facchetti, Klaus Rajewsky, Stefano Casola
Similar to resting mature B cells, where the B-cell antigen receptor (BCR) controls cellular survival, surface BCR expression is conserved in most mature B-cell lymphomas. The identification of activating BCR mutations and the growth disadvantage upon BCR knockdown of cells of certain lymphoma entities has led to the view that BCR signalling is required for tumour cell survival. Consequently, the BCR signalling machinery has become an established target in the therapy of B-cell malignancies. Here we study the effects of BCR ablation on MYC-driven mouse B-cell lymphomas and compare them with observations in human Burkitt lymphoma...
June 8, 2017: Nature
https://www.readbyqxmd.com/read/28561420/cab4b-the-first-human-platelet-antigen-carried-by-gpix-discovered-in-a-context-of-severe-neonatal-thrombocytopenia
#18
V Jallu, T Beranger, F Bianchi, C Casale, C Chenet, N Ferre, S Philippe, J Quesne, C Martageix, R Petermann
BACKGROUND: After 3 miscarriages, a 39-year-old woman gave birth at 1 year interval to 2 severely thrombocytopenic neonates (4 and 33 G/L) with intracranial haemorrhages. Transfusion of platelets concentrates corrected thrombocytopenias. The outcome was favourable for the 1(st) child but the second one died 10 days after caesarean delivery (31 WG + 6 days). METHODS: Serological studies were performed using MAIPA and flow cytometry techniques. Human platelet antigens (HPA) genotyping was done by using the BioArray HPA BeadChip and PCR-SSP techniques...
May 31, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28560754/oncostatin-m-induces-rig-i-and-mda5-expression-and-enhances-the-double-stranded-rna-response-in-fibroblasts
#19
Sabine Hergovits, Christine Mais, Claude Haan, Ana P Costa-Pereira, Heike M Hermanns
Interleukin (IL)-6-type cytokines have no direct antiviral activity; nevertheless, they display immune-modulatory functions. Oncostatin M (OSM), a member of the IL-6 family, has recently been shown to induce a distinct number of classical interferon stimulated genes (ISG). Most of them are involved in antigen processing and presentation. However, induction of retinoic acid-inducible gene (RIG)-I-like receptors (RLR) has not been investigated. Here we report that OSM has the capability to induce the expression of the DExD/H-Box RNA helicases RIG-I and melanoma differentiation antigen 5 (MDA5) as well as of the transcription factors interferon regulatory factor (IRF)1, IRF7 and IRF9 in primary fibroblasts...
May 30, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28552396/the-effect-of-histone-acetyl-transferase-inhibitor-trichostatin-a-on-porcine-mesenchymal-stem-cell-transcriptome
#20
Artur Gurgul, Jolanta Opiela, Klaudia Pawlina, Tomasz Szmatoła, Michał Bochenek, Monika Bugno-Poniewierska
The use of histone acetyl-transferase inhibitors such as trichostatin A (TSA) for epigenetic transformation of mesenchymal stem cells (MSCs), whose nuclei will be transferred into enucleated oocytes, is a novel approach in research involving somatic cell cloning of pigs and other mammalian species. Although the effectiveness of TSA in cloning applications was confirmed, processes and mechanisms underlying achieved effects are not yet fully understood, especially for pig MSCs. To contribute to this knowledge, in this study we performed a comprehensive transcriptome analysis using high-throughput sequencing of pig bone-marrow derived MSCs, both treated and untreated with TSA, and evaluated the effect of TSA administration on their transcription profile after 24 h of in vitro culture...
May 25, 2017: Biochimie
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