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https://www.readbyqxmd.com/read/29455444/persistent-left-superior-vena-cava-with-thrombus-formed-in-the-catheter-lumen-4-h-after-dialysis-catheter-placed
#1
Tomoki Kawasaki, Hiroyuki Tanaka, Miki Oba, Megumi Takada, Haruna Tanaka, Shin Suda
Persistent left superior vena cava (PLSVC) is one of the most common thoracic venous anomaly and rarely noticed, because it is asymptomatic. However, for nephrologists, it is frequent enough to be encountered while placing hemodialysis catheters through the jugular vein. We report the case of 66-year-old patient with PLSVC presenting intrinsic thrombosis formation 4 h after dialysis catheter placed. Dialysis catheter was placed in the left internal jugular vein without resistance and any complication. PLSVC was detected after dialysis catheter insertion...
February 17, 2018: CEN Case Reports
https://www.readbyqxmd.com/read/29455202/phosphate-and-calcium-control-in-short-frequent-hemodialysis-with-the-nxstage-system-one-cycler-mass-balance-studies-and-comparison-with-standard-thrice-weekly-bicarbonate-dialysis
#2
Chiara Carla Maria Brunati, Francesca Gervasi, Costanza Casati, Maria Luisa Querques, Alberto Montoli, Giacomo Colussi
BACKGROUND: Short frequent dialysis with NxStage System One cycler (NSO) has become increasingly popular as home hemodialysis prescription. Short dialysis sessions with NSO might not allow adequate phosphate (P) removal. METHODS: Single-session and weekly balances of P and calcium (Ca) were compared in 14 patients treated with NSO (6 sessions/week) and in 14 patients on standard bicarbonate dialysis (BHD). RESULTS: NSO and BHD showed similar plasma P fall, with end-dialysis plasma P slightly lower in BHD (2...
February 16, 2018: Blood Purification
https://www.readbyqxmd.com/read/29447254/loop-diuretics-are-associated-with-greater-risk-of-sarcopenia-in-patients-with-non-dialysis-dependent-chronic-kidney-disease
#3
Seiko Ishikawa, Shotaro Naito, Soichiro Iimori, Daiei Takahashi, Moko Zeniya, Hidehiko Sato, Naohiro Nomura, Eisei Sohara, Tomokazu Okado, Shinichi Uchida, Tatemitsu Rai
INTRODUCTION: Sarcopenia, the age-related loss of muscle mass and function, frequently accompanies chronic kidney disease. The aim of this study was to clarify the prevalence and the risk factors for sarcopenia among patients with non-dialysis-dependent chronic kidney disease (NDD-CKD), focusing on the use of drugs. METHODS: We conducted a cross-sectional analysis on a cohort of 260 patients with NDD-CKD in a university hospital, recruited between June 2016 and March 2017...
2018: PloS One
https://www.readbyqxmd.com/read/29441480/prognostic-value-of-cardiovascular-calcifications-in-hemodialysis-patients-a-longitudinal-study
#4
Nada Dimkovic, Georg Schlieper, Aleksandar Jankovic, Zivka Djuric, Marcus Ketteler, Tatjana Damjanovic, Petar Djuric, Jelena Marinkovic, Zoran Radojcic, Natasa Markovic, Jürgen Floege
PURPOSE: Cardiovascular calcifications (CVC) are present in up to 70% of non-diabetic dialysis patients. Sparse data are available on predictors of very long-term outcomes of such patients. The Belgrade Aachen Study on Calcification in Hemodialysis patients (BASCH study) aimed to study this using a comprehensive CVC assessment. METHODS: We prospectively analyzed 220 hemodialysis patients followed for a mean of 76 months (median 73 months, range 6-160 months). We compared patients deceased from cardiovascular diseases (CVD) and survivors...
February 13, 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/29437874/comparison-of-species-and-cell-type-differences-in-fraction-unbound-of-liver-tissues-hepatocytes-and-cell-lines
#5
Keith A Riccardi, Sangwoo Ryu, Jian Lin, Phillip Yates, David A Tess, Rui Li, Dhirender Singh, Brian R Holder, Brendon Kapinos, George Chang, Li Di
Fraction unbound (fu) of liver tissue, hepatocytes and other cell types is an essential parameter used to estimate unbound liver drug concentration and intracellular free drug concentration. Fu,liver and fu,cell are frequently measured in multiple species and cell types in drug discovery and development for various applications. A comparison study of 12 matrices for fu,liver and fu,cell of hepatocytes in five different species (mouse, rat, dog, monkey and human), as well as fu,cell of Huh7 and HEK-293 cell lines, was conducted for 22 structurally diverse compounds with the equilibrium dialysis method...
February 2, 2018: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/29429750/arteriovenous-fistula-maturation-in-prevalent-hemodialysis-patients-in-the-united-states-a%C3%A2-national%C3%A2-study
#6
Kenneth J Woodside, Sarah Bell, Purna Mukhopadhyay, Kaitlyn J Repeck, Ian T Robinson, Ashley R Eckard, Sudipta Dasmunshi, Brett W Plattner, Jeffrey Pearson, Douglas E Schaubel, Ronald L Pisoni, Rajiv Saran
BACKGROUND: Arteriovenous fistulas (AVFs) are the preferred form of hemodialysis vascular access, but maturation failures occur frequently, often resulting in prolonged catheter use. We sought to characterize AVF maturation in a national sample of prevalent hemodialysis patients in the United States. STUDY DESIGN: Nonconcurrent observational cohort study. SETTING & PARTICIPANTS: Prevalent hemodialysis patients having had at least 1 new AVF placed during 2013, as identified using Medicare claims data in the US Renal Data System...
February 8, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29423194/women-and-renal-replacement-therapy-in-europe-lower-incidence-equal-access-to-transplantation-longer-survival-than-men
#7
Raul Fernandez-Prado, Beatriz Fernandez-Fernandez, Alberto Ortiz
In 2018, World Kidney Day (WKD) and International Women's Day coincide. The WKD editorial focuses on women's kidney health. The European Renal Association-European Dialysis and Transplant Association (ERA-EDTA) Registry Annual Report 2015 summary provides an excellent snapshot of renal replacement therapy (RRT) epidemiology and women in Europe. The WKD editorial reports a lower incidence of RRT in women in major registries and potential limitations to women's access to transplantation. What is the situation in Europe? In Europe, the incidence of RRT is also lower in women: 38% of incident RRT patients are women...
February 2018: Clinical Kidney Journal
https://www.readbyqxmd.com/read/29421800/health-related-quality-of-life-and-its-factors-of-hemodialysis-patients-in-suzhou-china
#8
Chen-Wei Pan, Yin Wu, Hui-Jun Zhou, Bin-Xian Xu, Pei Wang
BACKGROUND: To identify factors of health-related quality of life (HRQOL) of Chinese end-stage renal disease patients undergoing hemodialysis (HD). METHODS: In all, 315 HD patients were recruited from a tertiary hospital in Suzhou, -China. Each patient completed the Kidney Disease Quality of Life Short Form. It generated 4 types of HRQOL scores: PCS score, MCS score, kidney disease component summary (KDCS) score, and SF-6D index score. Multiple linear regressions were conducted to identify the factors associated with each of the scores...
February 8, 2018: Blood Purification
https://www.readbyqxmd.com/read/29415664/gender-related-differences-in-clinicopathological-characteristics-and-renal-outcomes-of-chinese-patients-with-iga-nephropathy
#9
Wei Deng, Xiaojun Tan, Qian Zhou, Zhen Ai, Wenting Liu, Wei Chen, Xueqing Yu, Qiongqiong Yang
BACKGROUND: The prognostic effect of gender on immunoglobulin A nephropathy (IgAN) is not clear. We explored gender-related differences in clinicopathological features and renal outcomes in IgAN. METHODS: This was a single-centre retrospective study. Patients were divided into two groups according to gender. The clinicopathological features at biopsy and renal outcomes during the follow-up were collected and analysed. Renal outcomes were defined as the doubling of baseline serum creatinine and end-stage renal disease (ESRD) (estimated glomerular filtration rate < 15 mL/min/1...
February 7, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29409679/peritoneal-dialysis-a-factor-of-risk-or-protection-for-posterior-reversible-encephalopathy-syndrome-review-of-the-literature
#10
Mercedes Moreiras-Plaza, Francisco Fernández-Fleming, Naiara Azkárate-Ramírez, Walfred Nájera-de la Garza, Isabel Martín-Baez, Maria Hernansanz-Pérez
Posterior reversible encephalopathy syndrome is a clinical and radiological entity with acute or subacute neurological presentation associated with brain lesions that primarily affect the white matter of the posterior regions. It is often associated with the rapid onset of severe hypertension and/or with kidney failure (acute and chronic), but it has also been reported as a neurological complication in several medical conditions. In recent years, there has been an increase in the number of cases and related publications due to the advance of diagnostic imaging techniques...
February 3, 2018: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/29402860/effect-of-sedative-hypnotic-medicines-on-mortality-in-peritoneal-dialysis-patients-with-sleep-disorders-a-retrospective-cohort-study
#11
Ying Zhou, Peiran Yin, Bin Li, Jianying Li, Naya Huang, Haishan Wu, Habib Ullah, Xiao Yang, Xueqing Yu
BACKGROUND: Sedative-hypnotic medication is widely used among continuous ambulatory peritoneal dialysis (CAPD) patients with sleep disorders; however, its effect on mortality has rarely been investigated. METHODS: Logistic regression was employed to identify factors associated with sedative-hypnotic medication, whose effect on mortality was evaluated by Cox proportional hazards models. RESULTS: A total of 146 CAPD patients with sleep disorders were recruited, of which 46 patients (31...
December 12, 2017: Blood Purification
https://www.readbyqxmd.com/read/29395485/omega-3-polyunsaturated-fatty-acid-supplementation-to-prevent-arteriovenous-fistula-and-graft-failure-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#12
Andrea K Viecelli, Ashley B Irish, Kevan R Polkinghorne, Carmel M Hawley, David W Johnson, Trevor A Mori, Elaine M Pascoe, Giovanni F M Strippoli, Charmaine E Lok, Suetonia C Palmer
BACKGROUND: Arteriovenous access failure frequently occurs in people on hemodialysis and is associated with morbidity, mortality and large healthcare expenditures. Omega-3 polyunsaturated fatty acids (omega-3 PUFA) may improve access outcomes via pleiotropic effects on access maturation and function, but may cause bleeding complications. STUDY DESIGN: Systematic review with meta-analysis. SETTING & POPULATION: Adults requiring hemodialysis via arteriovenous fistula or graft...
January 27, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29395340/primary-outcomes-of-the-monitoring-in-dialysis-study-indicate-that-clinically-significant-arrhythmias-are-common-in-hemodialysis-patients-and-related-to-dialytic-cycle
#13
Prabir Roy-Chaudhury, Jim A Tumlin, Bruce A Koplan, Alexandru I Costea, Vijay Kher, Don Williamson, Saurabh Pokhariyal, David M Charytan
Sudden death is one of the more frequent causes of death for hemodialysis patients, but the underlying mechanisms, contribution of arrhythmia, and associations with serum chemistries or the dialysis procedure are incompletely understood. To study this, implantable loop recorders were utilized for continuous cardiac rhythm monitoring to detect clinically significant arrhythmias including sustained ventricular tachycardia, bradycardia, asystole, or symptomatic arrhythmias in hemodialysis patients over six months...
January 27, 2018: Kidney International
https://www.readbyqxmd.com/read/29393217/impact-of-recurrent-acute-kidney-injury-on-patient-outcomes
#14
Eva Rodríguez, Carlos Arias-Cabrales, Sheila Bermejo, Adriana Sierra, Carla Burballa, María José Soler, Clara Barrios, Julio Pascual
BACKGROUND/AIMS: Recurrent acute kidney injury (AKI) is common among patients after a first hospitalized AKI. However, little is known about the prognosis of recurrent AKI episodes in chronic kidney disease (CKD) development, cardiovascular events and mortality. METHODS: A retrospective study included patients admitted to our Hospital from 2000 to 2010. AKI was defined according to the Acute Dialysis Quality Initiative criteria. In the follow-up period after the first AKI episode, clinical, laboratory data and the number of repeated AKI episodes, etiology and severity were recorded...
January 23, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29386308/effects-of-oral-paricalcitol-and-calcitriol-treatment-on-peritoneal-membrane-characteristics-of-peritoneal-dialysis-patients-a-pilot-study
#15
Karima Farhat, Andrea W Stavenuiter, Marc Vervloet, Pieter M Ter Wee, Robert H Beelen, Frans J van Ittersum
BACKGROUND: Long-term peritoneal dialysis (PD) is frequently complicated by technique failure preceded by peritoneal remodeling. Vitamin D has potent immunomodulatory characteristics: anti-inflammatory, anti-angiogenic, anti-fibrotic properties, and influences on the macrophage phenotype. Little is known about the relation between pleiotropic effects attributed to vitamin D3 and the peritoneal membrane and what is the most appropriate vitamin D sterol in prevention of peritoneal remodeling in PD patients...
January 31, 2018: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/29383580/sickle-cell-nephropathy-an-update-on-pathophysiology-diagnosis-and-treatment
#16
REVIEW
Essa Hariri, Anthony Mansour, Andrew El Alam, Yazan Daaboul, Serge Korjian, Sola Aoun Bahous
Sickle cell nephropathy is a major complication of sickle cell disease. It manifests in different forms, including glomerulopathy, proteinuria, hematuria, and tubular defects, and frequently results in end-stage renal disease (ESRD). Different pathophysiologic mechanisms have been proposed to explain the development of nephropathy in SCD, where hemolysis and vascular occlusion are the main contributors in the manifestations of this disease. Markers of renal injury, such as proteinuria and tubular dysfunction, have been associated with outcomes among patients with sickle cell nephropathy and provide means for early detection of nephropathy and screening prior to progression to renal failure...
January 30, 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/29380499/removal-of-vancomycin-administered-during-dialysis-by-a-high-flux-dialyzer
#17
Heather A Nyman, Adhish Agarwal, Harry O Senekjian, John K Leypoldt, Alfred K Cheung
INTRODUCTION: Hemodialysis patients frequently receive vancomycin for treatment of gram-positive bacterial infections. This drug is most conveniently administered in outpatient dialysis units during the hemodialysis treatment. However, there is a paucity of data on the removal of vancomycin by high-flux polyamide dialyzers. METHODS: This is a prospective crossover study in which seven uninfected chronic hemodialysis patients at three dialysis units received vancomycin 1 gram intravenously over one hour immediately after the dialysis treatment (Phase 1), and vancomycin 1...
January 30, 2018: Hemodialysis International
https://www.readbyqxmd.com/read/29373244/race-and-sex-disparities-in-outcomes-of-dialysis-access-maintenance-interventions
#18
Premal S Trivedi, Kimberly E Lind, Charles E Ray, Paul J Rochon, Robert K Ryu
PURPOSE: To determine whether utilization and outcomes of dialysis access maintenance interventions vary by patient race or sex. MATERIALS AND METHODS: Data for this retrospective cohort study of first-time arteriovenous (AV) access recipients were drawn from a 5% sample of Medicare beneficiaries, containing claims from all clinical settings (2009-2014) in 2,693 patients who received their first AV fistula/graft in 2009. Maintenance interventions-angiography, angioplasty, thrombolysis, stent placement, and venous embolization-were identified by corresponding Current Procedural Terminology codes...
January 17, 2018: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/29369449/biomarkers-for-acute-kidney-injury-in-decompensated-cirrhosis-a-prospective-study
#19
David A Jaques, Laurent Spahr, Gregory Berra, Vincent Poffet, Pierre Lescuyer, Eric Gerstel, Nicolas Garin, Pierre-Yves Martin, Belen Ponte
BACKGROUND: Acute kidney injury (AKI) is a frequent complication in cirrhotic patients. As serum creatinine is a poor marker of renal function in this population, we aimed to study the utility of several biomarkers in this context. METHODS: A prospective study was conducted in hospitalized patients with decompensated cirrhosis. Serum creatinine (SCr), Cystatin C (CystC), NGAL and urinary NGAL, KIM-1, protein, albumin and sodium were measured on three separate occasions...
January 25, 2018: Nephrology
https://www.readbyqxmd.com/read/29362960/effect-of-intradialytic-exercise-on-daily-physical-activity-and-sleep-quality-in-maintenance-hemodialysis-patients
#20
Ji-Hyung Cho, Ji-Yeon Lee, Sukyung Lee, Hyuntae Park, Seung-Wook Choi, Jun Chul Kim
PURPOSE: Physical inactivity and sleep disturbance are frequently observed and relate to poor clinical outcomes in maintenance hemodialysis patients. We aimed to investigate the effect of intradialytic exercise on daily physical activity and sleep quality, measured by an accelerometer, in maintenance hemodialysis patients. METHODS: This study randomly assigned ambulatory maintenance hemodialysis patients aged ≥ 20 years on dialysis ≥ 6 months, without a hospitalization history for the previous 3 months to 4 groups: aerobic exercise (AE), resistance exercise (RE), combination exercise (CE), and control...
January 23, 2018: International Urology and Nephrology
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