keyword
MENU ▼
Read by QxMD icon Read
search

Brain hyperactivity

keyword
https://www.readbyqxmd.com/read/29792238/mapping-the-neuroanatomic-substrates-of-cognition-in-familial-attention-deficit-hyperactivity-disorder
#1
Rachel Muster, Saadia Choudhury, Wendy Sharp, Steven Kasparek, Gustavo Sudre, Philip Shaw
BACKGROUND: While the neuroanatomic substrates of symptoms of attention deficit hyperactivity disorder (ADHD) have been investigated, less is known about the neuroanatomic correlates of cognitive abilities pertinent to the disorder, particularly in adults. Here we define the neuroanatomic correlates of key cognitive abilities and determine if there are associations with histories of psychostimulant medication. METHODS: We acquired neuroanatomic magnetic resonance imaging data from 264 members of 60 families (mean age 29...
May 24, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29789937/visual-and-auditory-steady-state-responses-in-attention-deficit-hyperactivity-disorder
#2
Ali Khaleghi, Hadi Zarafshan, Mohammad Reza Mohammadi
We designed a study to investigate the patterns of the steady-state visual evoked potential (SSVEP) and auditory steady-state response (ASSR) in adolescents with attention-deficit/hyperactivity disorder (ADHD) when performing a motor response inhibition task. Thirty 12- to 18-year-old adolescents with ADHD and 30 healthy control adolescents underwent an electroencephalogram (EEG) examination during steady-state stimuli when performing a stop-signal task. Then, we calculated the amplitude and phase of the steady-state responses in both visual and auditory modalities...
May 22, 2018: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/29785533/stressful-life-events-adhd-symptoms-and-brain-structure-in-early-adolescence
#3
Kathryn L Humphreys, Emily L Watts, Emily L Dennis, Lucy S King, Paul M Thompson, Ian H Gotlib
Despite a growing understanding that early adversity in childhood broadly affects risk for psychopathology, the contribution of stressful life events to the development of symptoms of attention-deficit/hyperactivity disorder (ADHD) is not clear. In the present study, we examined the association between number of stressful life events experienced and ADHD symptoms, assessed using the Attention Problems subscale of the Child Behavior Checklist, in a sample of 214 children (43% male) ages 9.11-13.98 years (M = 11...
May 21, 2018: Journal of Abnormal Child Psychology
https://www.readbyqxmd.com/read/29785227/alterations-in-the-three-components-of-selfhood-in-persons-with-post-traumatic-stress-disorder-symptoms-a-pilot-qeeg-neuroimaging-study
#4
Andrew A Fingelkurts, Alexander A Fingelkurts
Background and Objective: Understanding how trauma impacts the self-structure of individuals suffering from the Post-Traumatic Stress Disorder (PTSD) symptoms is a complex matter and despite several attempts to explain the relationship between trauma and the "Self", this issue still lacks clarity. Therefore, adopting a new theoretical perspective may help understand PTSD deeper and to shed light on the underlying psychophysiological mechanisms. Methods: In this study, we employed the "three-dimensional construct model of the experiential selfhood" where three major components of selfhood (phenomenal first-person agency, embodiment, and reflection/narration) are related to three Operational Modules (OMs) of the self-referential brain network...
2018: Open Neuroimaging Journal
https://www.readbyqxmd.com/read/29778625/the-mediating-role-of-phosphodiesterase-type-4-in-the-dopaminergic-modulation-of-motor-impulsivity
#5
P R A Heckman, A Blokland, N P Van Goethem, B T J Van Hagen, J Prickaerts
The current study investigated the mediating role of phosphodiesterase type 4 (PDE4) regulated cAMP in the dopaminergic modulation of premature responding (action restraint) in rats. Response inhibition, which includes action restraint, finds its neurobiological origin in cortico-striatal-thalamic circuitry and can be modulated by dopamine. Intracellularly, the effect of dopamine is largely mediated through the cAMP/PKA signaling cascade. Areas in the prefrontal cortex are very sensitive to their neurochemical environment, including catecholamine levels...
May 17, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29772390/pathobiology-of-christianson-syndrome-linking-disrupted-endosomal-lysosomal-function-with-intellectual-disability-and-sensory-impairments
#6
Mallory Kerner-Rossi, Maria Gulinello, Steven Walkley, Kostantin Dobrenis
Christianson syndrome (CS) is a recently described rare neurogenetic disorder presenting early in life with a broad range of neurological symptoms, including severe intellectual disability with nonverbal status, hyperactivity, epilepsy, and progressive ataxia due to cerebellar atrophy. CS is due to loss-of-function mutations in SLC9A6, encoding NHE6, a sodium-hydrogen exchanger involved in the regulation of early endosomal pH. Here we review what is currently known about the neuropathogenesis of CS, based on insights from experimental models, which to date have focused on mechanisms that affect the CNS, specifically the brain...
May 14, 2018: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29771818/suppressed-acoustic-startle-response-in-traumatic-brain-injury-masks-post-traumatic-stress-disorder-hyper-responsivity
#7
Grant M Liska, Jea-Young Lee, Kaya Xu, Paul R Sanberg, Cesario V Borlongan
An exaggerated acoustic startle reflex (ASR) is a clinical indicator of anxiety disorders, such as post-traumatic stress disorder (PTSD). Given the prevalence of PTSD following traumatic brain injury (TBI), we studied the effects of TBI on ASR. Adult Sprague Dawley rats exposed to moderate controlled cortical impact injury model of TBI displayed suppression of ASR intensity and sensitivity. As patients with PTSD have been shown to display hyperactive startle responses, the present discrepant observation of TBI-induced suppression of ASR has clinical implications, in that the reduced, instead of elevated, startle response in patients with comorbid TBI/PTSD could be owing to a masking effect of TBI...
May 16, 2018: Neuroreport
https://www.readbyqxmd.com/read/29769613/genetic-variant-for-behavioral-regulation-factor-of-executive-function-and-its-possible-brain-mechanism-in-attention-deficit-hyperactivity-disorder
#8
Xiao Sun, Zhaomin Wu, Qingjiu Cao, Ying Qian, Yong Liu, Binrang Yang, Suhua Chang, Li Yang, Yufeng Wang
As a childhood-onset psychiatric disorder, attention deficit hyperactivity disorder (ADHD) is complicated by phenotypic and genetic heterogeneity. Lifelong executive function deficits in ADHD are described in many literatures and have been proposed as endophenotypes of ADHD. However, its genetic basis is still elusive. In this study, we performed a genome-wide association study of executive function, rated with Behavioral Rating Inventory of Executive Function (BRIEF), in ADHD children. We identified one significant variant (rs852004, P = 2...
May 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29767302/amyloid-causes-intermittent-network-disruptions-in-cognitively-intact-older-subjects
#9
Susanne G Mueller
Recent findings in AD models but also human patients suggest that amyloid can cause intermittent neuronal hyperactivity. The overall goal of this study was to use dynamic fMRI analysis combined with graph analysis to a) characterize the graph analytical signature of two types of intermittent hyperactivity (spike-like (spike) and hypersynchronus-like (synchron)) in simulated data and b) to attempt to identify one of these signatures in task-free fMRIs of cognitively intact subjects (CN) with or without increased brain amyloid...
May 16, 2018: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/29765402/tlr4-nf-%C3%AE%C2%BA-b-signal-involved-in-depressive-like-behaviors-and-cytokine-expression-of-frontal-cortex-and-hippocampus-in-stressed-c57bl-6-and-ob-ob-mice
#10
Yihe Wang, Jingjing Xu, Yuan Liu, Ziyang Li, Xiaohong Li
Studies found that elevated levels of cytokines such as interleukin- (IL-) 1 β , IL-6, and tumor necrosis factor- α (TNF- α ) are closely associated with the pathogenesis of depression. Obesity providing a low-grade inflammation state was proposed to be implicated in susceptibility to depression in obesity. However, the alterations of cytokines and the TLR4-NF- κ B signal in the brain of normal-weight and obese mice under stress have not been fully elucidated. This study used chronic unpredictable mild stress (CUMS) to induce a depressive-like behavior in an animal model and examine depressive-like behaviors, memory changes, and serum corticosterone levels, as well as the expressions of cytokines and NF- κ B in the frontal cortex and hippocampus...
2018: Neural Plasticity
https://www.readbyqxmd.com/read/29765401/mixed-effects-modeling-of-neurofeedback-self-regulation-performance-moderators-for-learning-in-children-with-adhd
#11
Agnieszka Zuberer, Franziska Minder, Daniel Brandeis, Renate Drechsler
Introduction: Neurofeedback (NF) has gained increasing popularity as a training method for children and adults with attention deficit hyperactivity disorder (ADHD). However, it is unclear to what extent children learn to regulate their brain activity and in what way NF learning may be affected by subject- and treatment-related factors. Methods: In total, 48 subjects with ADHD (age 8.5-16.5 years; 16 subjects on methylphenidate (MPH)) underwent 15 double training sessions of NF in either a clinical or a school setting...
2018: Neural Plasticity
https://www.readbyqxmd.com/read/29764626/25-hydroxvitamin-d-concentrations-are-not-lower-in-children-with-bronchial-asthma-atopic-dermatitis-obesity-or-attention-deficient-hyperactivity-disorder-than-in-healthy-children
#12
Thomas Reinehr, Christian Langrock, Eckard Hamelmann, Thomas Lücke, Cordula Koerner-Rettberg, Martin Holtmann, Tanja Legenbauer, Stephanie Gest, Mirjam Frank, Börge Schmidt, Katharina Radkowski, Karl-Heinz Jöckel
Vitamin D (vitD) is involved in immune regulation, and its receptor has been identified in several tissues including lung, adipose tissue, brain, and skin. Based on these observations, it has been suggested that vitD has an essential role not only in bone metabolism but also in other diseases such as atopic dermatitis (AD), bronchial asthma (BA), attention-deficit/hyperactivity disorder (ADHD), and obesity because the affected tissues express vitD receptors. Furthermore, obesity, AD, and BA are regarded as inflammatory diseases...
April 2018: Nutrition Research
https://www.readbyqxmd.com/read/29758392/effects-of-mindfulness-and-psychoeducation-on-working-memory-in-adult-adhd-a-randomised-controlled-fmri-study
#13
Katharina Bachmann, Alexandra P Lam, Peter Sörös, Manuela Kanat, Eliza Hoxhaj, Swantje Matthies, Bernd Feige, Helge Müller, Jale Özyurt, Christiane M Thiel, Alexandra Philipsen
Adult attention-deficit/hyperactivity disorder (ADHD) is a serious mental disorder associated with impaired neurocognitive performance related to working memory function. Recent clinical trials have suggested that mindfulness is a promising intervention in adults with ADHD. We performed a randomised controlled clinical trial to investigate working memory (WM) with an n-back task in adults with ADHD during fMRI before and after an 8-week mindfulness intervention (MAP) compared with psychoeducation (PE). ADHD symptoms were assessed using the self- and observer-rated Conners Adult ADHD Rating Scales (CAARS)...
May 7, 2018: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/29757463/depression-related-behavioural-and-neuroendocrine-changes-in-the-spontaneously-diabetic-torii-sdt-fatty-rat-an-animal-model-of-type-2-diabetes-mellitus
#14
Katsuya Sakimura, Tatsuya Maekawa, Kazuo Sasagawa, Yukihito Ishii, Shin-Ichi Kume, Takeshi Ohta
Depression is one of the most common psychiatric diseases and is commonly comorbid with type 1 or 2 diabetes mellitus (DM). However, the pathophysiology underlying the depressive state in DM remains poorly understood. Animal models are useful tools to investigate the association between depression and DM. In the present study we investigated whether the Spontaneously Diabetic Torii (SDT) fatty rat, a novel animal model of type 2 DM, shows depression-related features. We assessed depression-like behaviour, hyperactivation of the hypothalamic-pituitary-adrenal (HPA) axis, and neurotransmitter levels in the brain...
May 14, 2018: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29752654/reduced-hemispheric-asymmetry-of-brain-anatomical-networks-in-attention-deficit-hyperactivity-disorder
#15
Dandan Li, Ting Li, Yan Niu, Jie Xiang, Rui Cao, Bo Liu, Hui Zhang, Bin Wang
Despite many studies reporting a variety of alterations in brain networks in patients with attention deficit hyperactivity disorder (ADHD), alterations in hemispheric anatomical networks are still unclear. In this study, we investigated topology alterations in hemispheric white matter in patients with ADHD and the relationship between these alterations and clinical features of the illness. Weighted hemispheric brain anatomical networks were first constructed for each of 40 right-handed patients with ADHD and 53 matched normal controls...
May 11, 2018: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/29749060/visual-processing-as-a-potential-endophenotype-in-youths-with-attention-deficit-hyperactivity-disorder-a-sibling-study-design-using-the-counting-stroop-functional-mri
#16
Li-Ying Fan, Chi-Yung Shang, Wen-Yih Isaac Tseng, Susan Shur-Fen Gau, Tai-Li Chou
Deficits in inhibitory control and visual processing are common in youths with attention-deficit/hyperactivity disorder (ADHD), but little is known about endophenotypes for unaffected siblings of youths with ADHD. This study aimed to investigate the potential endophenotypes of brain activation and performance in inhibitory control and visual processing among ADHD probands, their unaffected siblings, and neurotypical youths. We assessed 27 ADHD probands, 27 unaffected siblings, and 27 age-, gender-, and IQ-matched neurotypical youths using the counting Stroop functional magnetic resonance imaging and two tasks of the Cambridge Neuropsychological Test Automated Battery (CANTAB): rapid visual information processing (RVP) for inhibitory control and spatial span (SSP) for visual processing...
May 10, 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29748773/preliminary-evidence-of-altered-gray-matter-volume-in-subjects-with-internet-gaming-disorder-associations-with-history-of-childhood-attention-deficit-hyperactivity-disorder-symptoms
#17
Deokjong Lee, Kee Namkoong, Junghan Lee, Young-Chul Jung
Attention-deficit/hyperactivity disorder (ADHD) is commonly comorbid with Internet gaming disorder (IGD). Although childhood ADHD symptoms may decline during late brain maturation, structural alterations in some brain areas may persist into adulthood. This study investigated whether young adults with IGD and a history of childhood ADHD symptoms had gray matter volume (GMV) alterations that were distinct from subjects without a history of childhood ADHD. As an exploratory investigation, we conducted a whole-brain voxel-based morphometry with the diffeomorphic anatomical registration using an exponentiated Lie algebra algorithm and applied an uncorrected threshold at the voxel level for multiple comparisons...
May 11, 2018: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/29744804/frontal-lobe-functioning-during-a-simple-response-conflict-task-in-first-episode-psychosis-and-its-relationship-to-treatment-response
#18
Keith M Shafritz, Toshikazu Ikuta, Allison Greene, Delbert G Robinson, Juan Gallego, Todd Lencz, Pamela DeRosse, Peter B Kingsley, Philip R Szeszko
Prior functional magnetic resonance imaging (fMRI) studies have investigated the neural mechanisms underlying cognitive control in patients with psychosis with findings of both hypo- and hyperfrontality. One factor that may contribute to inconsistent findings is the use of complex and polyfactorial tasks to investigate frontal lobe functioning. In the current study we employed a simple response conflict task during fMRI to examine differences in brain activation between patients experiencing their first-episode of psychosis (n = 33) and age- and sex-matched healthy volunteers (n = 33)...
May 9, 2018: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/29741273/is-auditory-perceptual-timing-a-core-deficit-of-developmental-coordination-disorder
#19
Laurel J Trainor, Andrew Chang, John Cairney, Yao-Chuen Li
Time is an essential dimension for perceiving and processing auditory events, and for planning and producing motor behaviors. Developmental coordination disorder (DCD) is a neurodevelopmental disorder affecting 5-6% of children that is characterized by deficits in motor skills. Studies show that children with DCD have motor timing and sensorimotor timing deficits. We suggest that auditory perceptual timing deficits may also be core characteristics of DCD. This idea is consistent with evidence from several domains, (1) motor-related brain regions are often involved in auditory timing process; (2) DCD has high comorbidity with dyslexia and attention deficit hyperactivity, which are known to be associated with auditory timing deficits; (3) a few studies report deficits in auditory-motor timing among children with DCD; and (4) our preliminary behavioral and neuroimaging results show that children with DCD at age 6 and 7 have deficits in auditory time discrimination compared to typically developing children...
May 9, 2018: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/29738269/psychological-and-behavioural-difficulties-following-severe-tbi-in-adolescence-a-comparison-with-a-sample-of-peers-with-brain-lesions-of-other-origin-and-with-a-control-group
#20
Valentina Pastore, Susanna Galbiati, Monica Recla, Katia Colombo, Elena Beretta, Sandra Strazzer
OBJECTIVE: To describe behavioural and adjustment problems in a group of 57 adolescents with severe traumatic brain injury (TBI) and compare them with a clinical group of peers with brain lesions of other origin (N = 33) and a control group of healthy adolescents (N = 48). METHODS: All subjects received an age-appropriate assessment, including the child behaviour checklist (CBCL) 4/18, the strengths and difficulties questionnaire (SDQ) and the vineland adaptive behaviour scales (VABS)...
May 8, 2018: Brain Injury: [BI]
keyword
keyword
49402
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"