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https://www.readbyqxmd.com/read/28750365/a-novel-evaluation-for-predicting-aortic-complicated-lesions-using-calcification-on-chest-x-ray
#1
Yoshitaka Yamaguchi, Tomotaka Tanaka, Sohei Yoshimura, Masatoshi Koga, Kazuyuki Nagatsuka, Kazunori Toyoda
BACKGROUND: The aorta is a significant source of cerebral thromboembolisms. Aortic complicated lesions (ACLs) are key findings on transesophageal echocardiography (TEE) for assessing aortic sources of emboli to the brain. TEE is sometimes avoided due to its invasiveness. However, few reports have examined alternative methods for predicting ACLs. We investigated relationships between aortic arch calcification (AAC) on chest X-ray and ACLs. METHODS: Participants comprised 300 patients with acute ischemic stroke or transient ischemic attack who underwent TEE for the evaluation of the aortic arch and heart...
July 28, 2017: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/28750189/potencial-markers-and-metabolic-processes-involved-in-mechanism-of-radiation-induced-heart-injury
#2
Jan Slezak, Branislav Kura, Pavel Babal, Miroslav Barancik, Miroslav Ferko, Karel Frimmel, Barbora Kalocayova, Rakesh Kukreja, Antigone Lazou, Lucia Mezesova, Ludmila Okruhlicova, Tatiana Ravingerova, Pawan K Singal, Barbara Szeiffova Bacova, Csilla Viczenczova, Norbert Vrbjar, Narcis Tribulova
Irradiation of normal tissues leads to acute increase in reactive oxygen/nitrogen species that serve as intra and intercellular signaling to alter cell and tissue function. In the case of chest irradiation it can affect the heart, blood vessels and lungs, with consequent tissue remodelation and adverse side effects and symptoms. This complex process is orchestrated by a large number of interacting molecular signals, including cytokines, chemokines and growth factors. Inflammation, endothelial cell dysfunction, thrombogenesis, organ dysfunction and ultimate failing of the heart occur as a pathological entity - "radiation-induced heart disease" (RIHD) that is major source of morbidity and mortality...
July 27, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28749715/insomnia-and-autonomic-function-predict-well-being-in-patients-receiving-palliative-care
#3
Marco Warth, Jens Kessler, Hubert J Bardenheuer
BACKGROUND: The improvement of health-related quality of life (HRQOL) is one of the main treatment goals in end-of-life care. Although definitions and conceptualizations remain heterogeneous, many researchers proposed HRQOL to be considered as subjective patient well-being. However, research on its determinants in palliative care is rare, and little is known about the interplay between psychological and biological variables. OBJECTIVE: The aim of this study was to explain differences in terminally ill patients' acute well-being (AWB) by use of a multimethod approach, examining both self-ratings and physiological predictors...
July 27, 2017: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/28749400/a-novel-approach-for-characterizing-variations-in-serum-peptides-in-rheumatic-heart-disease
#4
Xiaochen Wu, Qin Yue, Weikun Jia, Jinbao Zhang, Hui Ouyang, Dong Xin, Yingbin Xiao
BACKGROUND & OBJECTIVES: Acute rheumatic fever and rheumatic heart disease (RHD) are important public health problems in developing countries. In this study, peptidomic analyses on RHD patients and healthy individuals were performed to characterize variations in serum peptide levels using label-free quantitation approaches. METHODS: Blood samples were obtained from 160 healthy controls and 160 RHD patients. Of the 448 identified peptides, 272 were analyzed by two label-free mass spectrometry methods, the spectral count and spectral index...
March 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/28749177/sprint-trial-it-s-not-just-the-blood-pressure
#5
Gijs Fn Berkelmans, Frank Lj Visseren, Nicole Em Jaspers, Wilko Spiering, Yolanda van der Graaf, Jannick An Dorresteijn
Background The SPRINT trial showed a beneficial effect of systolic blood pressure treatment targets of 120 mmHg on cardiovascular risk compared to targets of 140 mmHg. However, differences in medication use, most importantly diuretics, are suggested as an alternative explanation. This post-hoc analysis aimed to determine whether the reduced event rate can be attributed to changes in systolic blood pressure (ΔSBP) . Methods Analyses were based on all 9361 participants of the SPRINT trial. ΔSBP was defined as the change between baseline and 6-month follow-up systolic blood pressure...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28749044/video-assisted-thoracoscopic-lobectomy-after-percutaneous-coronary-intervention-in-lung-cancer-patients-with-concomitant-coronary-heart-disease
#6
Xin Li, YiLi Fu, JinBai Miao, Hui Li, Bin Hu
BACKGROUND: In recent years, based on clinical observations, the number of lung cancer patients with concomitant coronary heart disease (CHD) has gradually increased. However, because of the requirement of long-term anticoagulant therapy after percutaneous coronary intervention (PCI), some of these patients lose the opportunity for surgical treatment, resulting in tumor progression. The objective of this study was to determine the appropriate timing of video-assisted thoracic surgery (VATS) lobectomy after PCI without increasing perioperative cardiovascular risk...
July 27, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28748892/clinical-profile-of-geriatric-acute-kidney-injury-in-a-tertiary-care-center-from-south-india
#7
Eshwarappa Mahesh, Praveen Nallamuthu, Mahesh Kumar, Parampalli Rakesh Madhyastha, Gurudev Konanna
The incidence of acute kidney injury (AKI) is high in the elderly, who comprise an ever-growing segment of the population. Elderly patients pose a different set of diagnostic and therapeutic challenge owing to their associated comorbidities. AKI in the elderly is associated with an increased risk of mortality, morbidity, prolonged length of stay, and progression to chronic kidney disease. Data regarding the clinical profile of AKI in the elderly from the South Indian population are limited. Hence, we present this analysis of the etiological and prognostic factors associated with AKI in elderly population from South India...
July 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28748885/cardiac-status-in-children-with-acute-poststreptococcal-glomerulonephritis
#8
Tushar Idhate, Syed Ahmed Zaki, Preeti Shanbag
Acute poststreptococcal glomerulonephritis (PSGN) is the most common type of glomerulonephritis seen in children. It can affect multiple organs with heart being frequently involved. Yet, there are very few studies on cardiac status in children with PSGN and hence this study was conducted. All consecutive children from 1 month to 12 years of age, admitted over a two-year period with a diagnosis of PSGN, were included in the study. An electrocardiogram (ECG) and two-dimensional echocardiogram were performed in all patients on admission and repeated at six and 12 weeks, if abnormal...
July 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28748625/multiple-risk-factor-counseling-to-promote-heart-healthy-lifestyles-in-the-chest-pain-observation-unit-pilot-randomized-controlled-trial
#9
David A Katz, Mark Graber, Patricia Lounsbury, Mark W Vander Weg, Emily K Phillips, Christina Clair, Phillip A Horwitz, Xueya Cai, Alan J Christensen
OBJECTIVE: Admission to the chest pain observation unit (CPOU) may be an advantageous time for patients to consider heart-healthy lifestyle changes while undergoing diagnostic evaluation to rule out myocardial ischemia. The aim of this pragmatic trial was to assess the effectiveness of a multiple risk factor intervention in changing CPOU patients' health beliefs and readiness to change health behaviors. A secondary aim was to obtain preliminary estimates of the intervention's effect on diet, physical activity, and smoking...
July 27, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/28748371/acute-effects-of-heated-resistance-exercise-in-female-and-male-power-athletes
#10
Julia R Casadio, Adam G Storey, Fabrice Merien, Andrew E Kilding, James D Cotter, Paul B Laursen
PURPOSE: To determine the effects of heated resistance exercise on thermal strain, neuromuscular function and hormonal responses in power athletes. METHODS: Sixteen (n = 8 female; 8 male) highly trained power athletes completed a combined strength and power resistance exercise session in hot (HOT ~30 °C) and temperate (CON ~20 °C) conditions. Human growth hormone (hGH), cortisol and testosterone concentrations in plasma, peak power (counter-movement jump, CMJ) and peak force (isometric mid-thigh pull) were measured before and after each training session; thermoregulatory responses were monitored during training...
July 26, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28748119/uric-acid-in-the-pathogenesis-of-metabolic-renal-and-cardiovascular-diseases-a-review
#11
REVIEW
Usama A A Sharaf El Din, Mona M Salem, Dina O Abdulazim
The association between uric acid (UA) on one side and systemic hypertension (Htn), dyslipidemia, glucose intolerance, overweight, fatty liver, renal disease and cardiovascular disease (CVD) on the other side is well recognized. However, the causal relationship between UA and these different clinical problems is still debatable. The recent years have witnessed hundreds of experimental and clinical trials that favored the opinion that UA is a probable player in the pathogenesis of these disease entities. These studies disclosed the strong association between hyperuricemia and metabolic syndrome (MS), obesity, Htn, type 2 diabetes mellitus (DM), non-alcoholic fatty liver disease, hypertriglyceridemia, acute kidney injury, chronic kidney disease (CKD), coronary heart disease (CHD), heart failure and increased mortality among cardiac and CKD patients...
September 2017: Journal of Advanced Research
https://www.readbyqxmd.com/read/28747842/combined-application-of-extracorporeal-membrane-oxygenation-and-an-artificial-pacemaker-in-fulminant-myocarditis-in-a-child
#12
Sheng Ye, Lvchan Zhu, Botao Ning, Chenmei Zhang
Fulminant myocarditis is severe and aggressive, but it is self-limited and usually has a favorable prognosis if the patients can survive the acute phase. When drug treatment is not effective, extracorporeal membrane oxygenation technology should be applied to support cardiopulmonary function. Extracorporeal membrane oxygenation can simultaneously support function of the left ventricle, right ventricle, and lungs, and provide stable blood circulation for patients with heart and respiratory failure, which allows sufficient time for the cardiopulmonary system to recover...
June 2017: Türk Pediatri Arşivi
https://www.readbyqxmd.com/read/28747453/serum-matrix-metalloproteinase-9-levels-and-prognosis-of-acute-ischemic-stroke
#13
Chongke Zhong, Jingyuan Yang, Tan Xu, Tian Xu, Yanbo Peng, Aili Wang, Jinchao Wang, Hao Peng, Qunwei Li, Zhong Ju, Deqin Geng, Yonghong Zhang, Jiang He
OBJECTIVE: To examine the association between serum matrix metalloproteinases-9 (MMP-9) levels and prognosis of acute ischemic stroke. METHODS: We measured serum MMP-9 levels in 3,186 participants (2,008 men and 1,178 women) from the China Antihypertensive Trial in Acute Ischemic Stroke (CATIS). Study outcome data on death, major disability (modified Rankin Scale score ≥3), and vascular disease were collected at 3 months after stroke onset. RESULTS: During 3 months of follow-up, 767 participants (24...
July 26, 2017: Neurology
https://www.readbyqxmd.com/read/28747039/prior-beta-blockers-use-is-independently-associated-with-increased-inpatient-mortality-in-patients-presenting-with-acute-myocardial-infarction
#14
Yan Zhou, Suzhen Chen, Xiang Zhu, Junhong Gui, Khalid Abusaada
BACKGROUND: Beta blockers (BBs) are recommended for patients presenting with acute myocardial infarction. However, the effects of prior BBs use on inpatient mortality in patients presenting with acute myocardial infarction (AMI) are unknown. METHODS: This was a retrospective cohort study of patients presenting with AMI in Florida Hospital Orlando from January 1, 2013 to December 31, 2014. Data were collected prospectively, as part of the Acute Coronary Treatment and Intervention Outcomes Network (ACTION) Registry...
September 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28747037/increased-arterial-stiffness-is-an-independent-risk-factor-for-hemorrhagic-transformation-in-ischemic-stroke-undergoing-thrombolysis
#15
Maurizio Acampa, Silvia Camarri, Pietro Enea Lazzerini, Francesca Guideri, Rossana Tassi, Raffaella Valenti, Alessandra Cartocci, Giuseppe Martini
BACKGROUND: Hemorrhagic transformation (HT) is a multifactorial phenomenon and represents a possible complication of ischemic stroke, especially after thrombolytic treatment. Increased arterial stiffness has been associated with intracranial hemorrhage, but there is no evidence of association with HT after thrombolytic therapy. The aim of our study is to investigate a possible link between arterial stiffness and HT occurrence after thrombolytic therapy in patients with ischemic stroke...
September 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28746811/the-acute-effects-of-different-spironolactone-doses-on-cardiac-function-in-streptozotocin-induced-diabetic-rats
#16
Aleksandra Vranic, Stefan Simovic, Petar Ristic, Tamara R Nikolic, Isidora Stojic, Ivan M Srejovic, Vladimir I Zivkovic, Vladimir Jakovljevic, Dusan Djuric
Currently, cardiovascular diseases are leading cause of global mortality, while diabetes mellitus remains an important cause of cardiovascular morbidity. Findings suggest that obesity and diabetes mellitus are closely interconnected with high aldosterone levels, while mineralocorticoid receptors antagonist therapy has shown positive effects on cardiovascular complications associated with diabetes mellitus. A recent study showed that patients with diabetes mellitus treated with mineralocorticoid receptors antagonist have improved coronary microvascular function, leading to improved diastolic dysfunction...
July 26, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28746082/heartware-ventricular-assist-device-as-a-bridge-to-transplant-in-a-small-boy-with-complicated-kawasaki-disease
#17
Christopher E Mascio, Dhananjay P Malankar, Jonathan J Rome
We report a case of HeartWare ventricular assist device (HVAD) implant as a Bridge-to-Transplant in the smallest and the youngest known patient, a 32-month-old boy (body surface area of 0.66 m2) with known Kawasaki disease and giant coronary artery aneurysms. The disease course was complicated by coronary thromboembolism resulting in acute myocardial infarction, ventricular fibrillation, and cardiac arrest. After short-term support with extracorporeal membrane oxygenation for 7 days and long-term support with an HVAD for 5 months, he underwent heart transplantation and is doing well 2 months after the transplant...
July 25, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/28745846/acute-decompensated-heart-failure-new-strategies-for-improving-outcomes-digest
#18
Emily Singer Fisher, Boyd Burns, Jeremy Kim
Acute decompensated heart failure is a common emergency department presentation with significant associated morbidity and mortality. Heart failure accounts for more than 1 million hospitalizations annually, with a steadily increasing incidence as our population ages. This issue reviews recent literature regarding appropriate management of emergency department presentations of acute decompensated heart failure, with special attention to newer medication options. Emergency department management and appropriate interventions are discussed, along with critical decision-making points in resuscitation for both hypertensive and hypotensive patients...
May 22, 2017: Emergency Medicine Practice
https://www.readbyqxmd.com/read/28745784/clinical-research-of-different-analgesia-methods-on-perianesthetic-pain-of-patients-with-moderate-and-severe-craniocerebral-injury-who-have-emergency-operation
#19
Q Huang, H Xu, Q-S Xiao
OBJECTIVE: To compare the effects of two different analgesia methods on postoperative pain of patients with moderate and severe craniocerebral injury who had an emergency operation. PATIENTS AND METHODS: In this study, 64 patients who were treated in our hospital from January 2015 to January 2016 and diagnosed with acute craniocerebral injury, were consecutively selected. The patients were divided into the propofol total intravenous anesthesia group (the observation group) and the isoflurane intravenous-inhalation combined anesthesia group (the control group) randomly with 32 cases each...
July 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28745139/role-of-mir-29-as-marker-of-risk-of-acute-rejection-after-heart-transplant
#20
S Guo, X Guo, S Wang, Q Nie, G Ni, C Wang
BACKGROUND: Circulating miRNAs are potential biomarkers of the pathogenesis of certain diseases and in monitoring therapeutic responses. We hypothesized that serum miR-29 can determine risk of acute cardiac allograft rejection. METHODS: Peripheral vein blood was collected from 50 healthy volunteers and 506 patients during post-transplant surveillance. Serum cardiac troponin I (cTnI) and miR-29 was detected by ELISA and qRT-PCR assay respectively. Rejection risk was defined as International Society of Heart and Lung Transplant score from leukocyte infiltration of an endomyocardial biopsy...
July 26, 2017: British Journal of Biomedical Science
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