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https://www.readbyqxmd.com/read/28231264/precision-engineering-for-prrsv-resistance-in-pigs-macrophages-from-genome-edited-pigs-lacking-cd163-srcr5-domain-are-fully-resistant-to-both-prrsv-genotypes-while-maintaining-biological-function
#1
Christine Burkard, Simon G Lillico, Elizabeth Reid, Ben Jackson, Alan J Mileham, Tahar Ait-Ali, C Bruce A Whitelaw, Alan L Archibald
Porcine Reproductive and Respiratory Syndrome (PRRS) is a panzootic infectious disease of pigs, causing major economic losses to the world-wide pig industry. PRRS manifests differently in pigs of all ages but primarily causes late-term abortions and stillbirths in sows and respiratory disease in piglets. The causative agent of the disease is the positive-strand RNA PRRS virus (PRRSV). PRRSV has a narrow host cell tropism, limited to cells of the monocyte/macrophage lineage. CD163 has been described as a fusion receptor for PRRSV, whereby the scavenger receptor cysteine-rich domain 5 (SRCR5) region was shown to be an interaction site for the virus in vitro...
February 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28230563/implementation-of-an-early-mobility-pathway-in-neurointensive-care-unit-patients-with-external-ventricular-devices
#2
Megan Moyer, Bethany Young, Joseph Borst, William Pino, Marisa Hart, Jesse LoBreglio, Derek Zaleski, Isaira Leonor, David Kung, Michelle Smith, Eric Zager, M Sean Grady, Monisha Kumar
BACKGROUND: Patients with an external ventricular drain (EVD) may not be readily mobilized because of concerns of catheter dislodgment and/or inappropriate cerebrospinal fluid drainage. Delayed mobilization may result in longer hospital stays and an increased risk for complications related to immobility. We aimed to determine the safety, feasibility, and outcome of an EVD mobilization protocol in patients with subarachnoid hemorrhage (SAH). METHODS: A multidisciplinary group developed a formal algorithm for the mobilization of patients with SAH with EVDs...
February 23, 2017: Journal of Neuroscience Nursing: Journal of the American Association of Neuroscience Nurses
https://www.readbyqxmd.com/read/28229160/pregnancy-outcome-of-first-trimester-exposure-to-the-vitamin-k-antagonist-phenprocoumon-depends-on-duration-of-treatment
#3
Eleanor Hüttel, Stephanie Padberg, Reinhard Meister, Evelin Beck, Christof Schaefer
The aim of this observational cohort study was to specify the risk of the vitamin K antagonist (VKA) phenprocoumon during first trimester of pregnancy, in particular to estimate the risk of birth defects and spontaneous fetal loss. Four hundred eight pregnancies with phenprocoumon exposure were compared to 1,642 pregnancies neither exposed to VKA nor to other major teratogens or fetotoxicants. There was no typical warfarin embryopathy in our exposed cohort. However, the overall rate of major birth defects was significantly increased (7...
February 23, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28226068/-multiple-causes-of-maternal-mortality-related-to-abortion-in-minas-gerais-state-brazil-2000-2011
#4
Eunice Francisca Martins, Pollyanna Ferraz Botelho de Almeida, Cilene de Oliveira Paixão, Paula Gonçalves Bicalho, Livia de Souza Pancrácio de Errico
This study aimed to analyze trends in maternal mortality from abortion in Minas Gerais State, Brazil, from 2000 to 2011, addressing multiple causes of death. The analysis focused on women's social and demographic characteristics, year, location, and underlying and associated causes of death. Maternal mortality ratio (MMR) and abortion-specific ratio were calculated for each year, as well as Spearman's correlation coefficient (p < 0.05), to assess the trend in ratios during the study period. One hundred and eighty-three deaths from abortion were recorded, accounting for 15% of maternal deaths, and MMR remained stable...
February 13, 2017: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/28224721/progesterone-driven-local-regulatory-t-cell-induction-does-not-prevent-fetal-loss-in-the-cba-j%C3%A3-dba-2j-abortion-prone-model
#5
Anne Schumacher, Dominique Dauven, Ana C Zenclussen
PROBLEM: Best known for its endocrine and immunologic properties, progesterone (P4) is a pivotal player for pregnancy success. However, the immunologic actions underlying P4 protection are not completely understood. Here, we investigated whether P4 application in a murine abortion-prone combination regulates regulatory T cells (Treg) and dendritic cells (DCs) and thereby affects pregnancy outcome. METHOD OF STUDY: Progesterone or vehicle was applied to DBA/2J-mated CBA/J abortion-prone animals in early pregnancy...
March 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28224271/the-perfect-womb-promoting-equality-of-fetal-opportunity
#6
Evie Kendal
This paper aims to address how artificial gestation might affect equality of opportunity for the unborn and any resultant generation of "ectogenetic" babies. It will first explore the current legal obstacles preventing the development of ectogenesis, before looking at the benefits of allowing this technology to control fetal growth and development. This will open up a discussion of the treatment/enhancement divide regarding the use of reproductive technologies, a topic featured in various bioethical debates on the subject...
February 21, 2017: Journal of Bioethical Inquiry
https://www.readbyqxmd.com/read/28222427/impact-of-fmr1-pre-mutation-status-on-blastocyst-development-in-patients-undergoing-pre-implantation-genetic-diagnosis
#7
Anne P Hutchinson, Nigel Pereira, Debra P Lilienthal, Siobhán Coveney, Jovana P Lekovich, Rony T Elias, Zev Rosenwaks
BACKGROUND/AIMS: The study aimed to investigate the impact of fragile X mental retardation 1 (FMR1) pre-mutation status on blastocyst development in patients undergoing pre-implantation genetic diagnosis (PGD). METHODS: Case-control study of patients <40 years undergoing PGD at blastocyst stage for FMR1 pre-mutation status. Age-matched patients undergoing PGD for other single gene disorders were considered controls. Blastocyst development, calculated per metaphase II (MII) oocyte retrieved and per 2 pronuclear (2PN) embryos, was compared between the 2 groups...
February 22, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/28219911/triple-negative-breast-cancer-with-brain-metastasis-in-a-pregnant-woman
#8
Francisco Trinca, Mariana Inácio, Teresa Timóteo, Rui Dinis
A woman aged 35 years was diagnosed with triple-negative breast cancer in October 2012. During the investigation, it was discovered that she was pregnant, the patient decided to have an abortion. She was submitted to a radical modified mastectomy and adjuvant chemotherapy followed by adjuvant breast radiotherapy of the left breast. 2 months after the adjuvant treatment, she began to have headaches and dizziness. The cranial MRI (head MRI) showed brain metastasis. She was then treated with whole brain radiotherapy, stereotactic radiosurgery and concomitant temozolomide which resulted in complete response...
February 20, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28219281/a-theory-of-unborn-life-from-abortion-to-genetic-manipulation
#9
Matt James
No abstract text is available yet for this article.
April 2016: New Bioethics: a Multidisciplinary Journal of Biotechnology and the Body
https://www.readbyqxmd.com/read/28219270/the-ethics-of-pregnancy-abortion-and-childbirth-exploring-moral-choices-in-childbearing
#10
Trevor Stammers
No abstract text is available yet for this article.
November 2016: New Bioethics: a Multidisciplinary Journal of Biotechnology and the Body
https://www.readbyqxmd.com/read/28219266/does-the-english-law-on-abortion-affront-human-dignity
#11
Charles Foster
The English law on abortion is examined through four lenses manufactured by the principle of dignity. Those lenses are embodiment, relationality, story and a transactional, rather than an atomistic, approach to the ascertaining of the relevant interests. It is contended that this approach gives more nuanced, humane, intellectually satisfactory and pastorally satisfactory answers than those generated by the existing law. It is further argued that only this dignity-based approach is compatible with that mandated by Article 8 of the ECHR...
November 2016: New Bioethics: a Multidisciplinary Journal of Biotechnology and the Body
https://www.readbyqxmd.com/read/28219264/we-are-not-gametes-distinguishing-between-abortion-and-contraception
#12
Toni Saad
It is sometimes argued that interruptions of the life's continuum which have the same end result are morally equivalent. In other words, abortion and contraception are ethically identical because both prevent birth and the development of persons. We will examine two major arguments in favour of this thesis: (1) all things that are potential persons have equal moral status. Hence preventing fertilisation of gametes is morally identical to destroying an embryo; (2) all interruptions of the continuous process which leads to the creation of a person are morally equivalent; abortion and contraception are morally indistinguishable...
November 2016: New Bioethics: a Multidisciplinary Journal of Biotechnology and the Body
https://www.readbyqxmd.com/read/28217618/recurrent-first-trimester-abortion-in-a-young-female-rare-presentation-of-takayasu-arteritis
#13
Suruchi Gupta, Puneet Chhabra, Nikhil Gupta, Parul Aggarwal
Takayasu arteritis (TA) is a chronic, progressive, autoimmune, idiopathic, and large-vessel vasculitis that usually affects young adults, especially females. TA primarily affects the aorta and its major branches, the coronary arteries, and the pulmonary arteries. Recurrent pregnancy loss is usually defined as three or more consecutive losses occurring at <20 weeks' gestation of a clinically recognized pregnancy. Common causes of recurrent fetal loss include anatomic, chromosomal, hormonal, infectious, or antiphospholipid antibody syndrome...
July 2016: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/28216912/pregnancy-outcomes-and-maternal-and-perinatal-complications-of-pregnancies-following-in-vitro-fertilization-intracytoplasmic-sperm-injection-using-own-oocytes-donor-oocytes-and-vitrified-embryos-a-prospective-follow-up-study
#14
Manish Banker, Vidhisha Mehta, Dipesh Sorathiya, Mira Dave, Sandeep Shah
BACKGROUND: Several global studies have assessed maternal and perinatal outcomes and complications with the type of embryo transfer (ET) following in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI). The present study assessed the incidence of maternal and perinatal outcomes and complications following IVF/ICSI associated with the type of embryo transferred. METHODOLOGY: A total of 2112 ETs were performed in 2092 female patients aged 21-50 years between January 1 and December 31, 2014 (Group A: Fresh ET using self-oocytes: 691; Group B: Fresh ET using donor oocytes: 810; and Group C: Thaw ET using vitrified-warmed embryos: 611)...
October 2016: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/28216547/mid-term-follow-up-of-school-aged-children-with-borderline-long-qt-interval
#15
Aya Miyazaki, Heima Sakaguchi, Yu Matsumura, Yosuke Hayama, Kanae Noritake, Jun Negishi, Etsuko Tsuda, Yoshihiro Miyamoto, Takeshi Aiba, Wataru Shimizu, Kengo Kusano, Isao Shiraishi, Hideo Ohuchi
BACKGROUND: There are no definitive diagnostic criteria or follow-up strategies for long QT syndrome (LQTS) in children with a borderline long QT interval (b-LQT).Methods and Results:We retrospectively evaluated the clinical course, genetic testing results, corrected QT interval (QTc), and LQTS score of 59 school-aged children (5-18 years old) with a b-LQT (400≤QTc<500 ms). Syncope, but neither aborted cardiac arrest nor sudden cardiac death, occurred in 2 patients during the follow-up (6±3...
February 18, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28212654/diversity-and-distribution-of-avian-malaria-and-related-haemosporidian-parasites-in-captive-birds-from-a-brazilian%C3%A2-megalopolis
#16
Carolina Romeiro Fernandes Chagas, Gediminas Valkiūnas, Lilian de Oliveira Guimarães, Eliana Ferreira Monteiro, Fernanda Junqueira Vaz Guida, Roseli França Simões, Priscila Thihara Rodrigues, Expedito José de Albuquerque Luna, Karin Kirchgatter
BACKGROUND: The role of zoos in conservation programmes has increased significantly in last decades, and the health of captive animals is essential to guarantee success of such programmes. However, zoo birds suffer from parasitic infections, which often are caused by malaria parasites and related haemosporidians. Studies determining the occurrence and diversity of these parasites, aiming better understanding infection influence on fitness of captive birds, are limited. METHODS: In 2011-2015, the prevalence and diversity of Plasmodium spp...
February 17, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28209623/access-to-contraception-and-sexual-and-reproductive-health-information-post-abortion-a-systematic-review-of-literature-from-low-and-middle-income-countries
#17
REVIEW
Claire Rogers, Jaya A R Dantas
AIM: This systematic literature review documented, analysed and critiqued the accessibility of contraception and sexual and reproductive health (SRH) information for women living in low- and middle-income countries who have undergone medical or surgical abortion. METHODOLOGY: This review systematically collated relevant and recent empirical evidence regarding women's access to contraception and SRH information post-abortion within low- and middle-income countries...
February 16, 2017: Journal of Family Planning and Reproductive Health Care
https://www.readbyqxmd.com/read/28209547/pregnancy-after-urinary-diversion-at-young-ages-risks-and-outcome
#18
N Huck, S Schweizerhof, P Honeck, A Neisius, J Thüroff, R Stein
OBJECTIVE: To assess the urological and obstetric outcomes during and after pregnancy following urinary diversion (UD) performed during childhood or adolescence. PATIENTS AND METHODS: From our urinary diversion database, we identified 25 females who became pregnant between 1981 and 2013. Reasons for urinary diversion were neurogenic bladder, exstrophy, trauma, sinus urogenitalis and interstitial cystitis. 17 had continent cutaneous diversion, 4 continent anal diversion and 4 colonic conduit...
February 13, 2017: Urology
https://www.readbyqxmd.com/read/28209376/-ethics-surrounding-the-provision-of-abortion-care
#19
REVIEW
Anibal Faúndes, Laura Miranda
The provision of abortion care represents a great ethical challenge to physicians, particularly in countries where the law states that abortion is a crime. The concept that it is a crime carries a stigma that is worse than that associated with other acts qualified by law as crimes. This stigma leads to at least two different kinds of unethical behavior. One is the refusal to provide safe abortion services to women who comply with the legal requirements, alleging conscientious objection, and the other is to discriminate against women with complications of induced abortion...
January 20, 2017: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/28209216/hypertrophic-cardiomyopathy-with-left%C3%A2-ventricular-apical-aneurysm-implications-for-risk-stratification-and-management
#20
Ethan J Rowin, Barry J Maron, Tammy S Haas, Ross F Garberich, Weijia Wang, Mark S Link, Martin S Maron
BACKGROUND: A previously under-recognized subset of hypertrophic cardiomyopathy (HCM) patients with left ventricular (LV) apical aneurysms is being identified with increasing frequency. However, risks associated with this subgroup are unknown. OBJECTIVES: The authors aimed to clarify clinical course and prognosis of a large cohort of HCM patients with LV apical aneurysms over long-term follow-up. METHODS: The authors retrospectively analyzed 1,940 consecutive HCM patients at 2 centers, 93 of which (4...
February 21, 2017: Journal of the American College of Cardiology
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