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https://www.readbyqxmd.com/read/28103512/protein-o-fucosyltransferase-1-promotes-trophoblast-cell-proliferation-through-activation-of-mapk-and-pi3k-akt-signaling-pathways
#1
Chang Liu, Xiaohua Liang, Jiao Wang, Qin Zheng, Yue Zhao, Muhammad Noman Khan, Shuai Liu, Qiu Yan
Protein O-fucosylation is an important glycosylation modification and plays an important role in embryonic development. Protein O-fucosyltransferase 1 (poFUT1) is an essential enzyme that catalyzes the synthesis of protein O-fucosylation. Our previous studies showed that poFUT1 promoted trophoblast cell migration and invasion at the fetal-maternal interface, but the role of poFUT1 in trophoblast cells proliferation remains unclear. Here, immunohistochemistry data showed that poFUT1 and PCNA levels were decreased in abortion patient's trophoblasts compared with women with normal pregnancies...
January 16, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28102101/thyroid-in-pregnancy-from-physiology-to-screening
#2
Drahomira Springer, Jan Jiskra, Zdenka Limanova, Tomas Zima, Eliska Potlukova
Thyroid hormones are crucial for the growth and maturation of many target tissues, especially the brain and skeleton. During critical periods in the first trimester of pregnancy, maternal thyroxine is essential for fetal development as it supplies thyroid hormone-dependent tissues. The ontogeny of mature thyroid function involves organogenesis, and maturation of the hypothalamus, pituitary and the thyroid gland; and it is almost complete by the 12th-14th gestational week. In case of maternal hypothyroidism, substitution with levothyroxine must be started in early pregnancy...
January 19, 2017: Critical Reviews in Clinical Laboratory Sciences
https://www.readbyqxmd.com/read/28101470/protective-roles-of-n-acetyl-cysteine-and-or-taurine-against-sumatriptan-induced-hepatotoxicity
#3
Javad Khalili Fard, Hossein Hamzeiy, Mohammadreza Sattari, Mohammad Ali Eghbal
Purpose: Triptans are the drug category mostly prescribed for abortive treatment of migraine. Most recent cases of liver toxicity induced by triptans have been described, but the mechanisms of liver toxicity of these medications have not been clear. Methods: In the present study, we obtained LC50 using dose-response curve and investigated cell viability, free radical generation, lipid peroxide production, mitochondrial injury, lysosomal membrane damage and the cellular glutathione level as toxicity markers as well as the beneficial effects of taurine and/or N-acetyl cysteine in the sumatriptan-treated rat parenchymal hepatocytes using accelerated method of cytotoxicity mechanism screening...
December 2016: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28100470/vacuum-aspiration-for-induced-abortion-could-be-safely-and-legally-performed-by-nurses-and-midwives
#4
Sally Sheldon, Joanne Fletcher
BACKGROUND: Some 40% of abortions carried out in England and Wales are done by vacuum aspiration. It is widely assumed that, in order to be lawful, these procedures must be performed by doctors. AIM AND DESIGN: This study aimed to provide a detailed reassessment of the relevant law and the clinical evidence that supports this assumption. CONCLUSIONS: A close reading of relevant law reveals that this assumption is unfounded. On the contrary, it would be lawful for appropriately trained nurses or midwives, acting as part of a multidisciplinary team, to carry out vacuum aspiration procedures...
January 18, 2017: Journal of Family Planning and Reproductive Health Care
https://www.readbyqxmd.com/read/28100116/physician-opinions-concerning-legal-abortion-in-bogot%C3%A3-colombia
#5
Kaitlyn Stanhope, Roger Rochat, Lauren Fink, Kalie Richardson, Chelsey Brack, Dawn Comeau
Since the decriminalisation of abortion in 2006, women in Colombia have continued to seek clandestine abortions, endangering their health and contributing to maternal mortality and morbidity. The goal of this study was to explore physicians' opinions towards and knowledge about legal abortion in Bogotá, Colombia, and key barriers to the legal abortion access. We conducted 13 key informant interviews followed by a survey with a probability sample of 49 doctors working in public hospitals in Bogotá. Interview and survey data showed lack of technical experience in the provision of abortion and nuanced opinions towards its practice...
January 19, 2017: Culture, Health & Sexuality
https://www.readbyqxmd.com/read/28100115/paternal-age-is-not-associated-with-pregnancy-outcomes-after-single-thawed-euploid-blastocyst-transfer
#6
Ashley W Tiegs, Nidhee M Sachdev, Jamie A Grifo, David H McCulloh, Frederick Licciardi
Although controversial, increasing paternal age has been shown to negatively affect assisted reproductive technology (ART) outcomes and success rates. Most studies investigating the effect of paternal age on ART outcomes use a donor oocyte model to minimize maternal aneuploidy contribution. This study sought to determine whether increasing paternal age is associated with adverse in vitro fertilization (IVF) outcomes when aneuploidy is minimized using preimplantation genetic screening. There were 573 single thawed euploid embryo transfers from 473 patients undergoing oocyte donor and autologous IVF cycles...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28100112/abortion-attitudes-among-south-africans-findings-from-the-2013-social-attitudes-survey
#7
Elizabeth A Mosley, Elizabeth J King, Amy J Schulz, Lisa H Harris, Nicole De Wet, Barbara A Anderson
Abortion is legal in South Africa, but over half of abortions remain unsafe there. Evidence suggests women who are (Black) African, of lower socioeconomic status, living with HIV, or residents of Gauteng, KwaZulu-Natal, or Limpopo provinces are disproportionately vulnerable to morbidity or mortality from unsafe abortion. Negative attitudes toward abortion have been documented in purposively sampled studies, yet it remains unclear what attitudes exist nationally or whether they differ across sociodemographic groups, with implications for inequities in service accessibility and health...
January 19, 2017: Culture, Health & Sexuality
https://www.readbyqxmd.com/read/28099741/abortion-choices-among-women-in-cambodia-after-introduction-of-a-socially-marketed-medicated-abortion-product
#8
Khim Sotheary, Dianna Long, Gary Mundy, Yasmin Madan, Paul D Blumenthal
OBJECTIVE: To assess whether a social marketing initiative focusing on medicated abortion via a mifepristone/misoprostol "combipack" has contributed to reducing unsafe abortion in Cambodia. METHODS: In a questionnaire-based cross-sectional study, annual household surveys were conducted across 13 Cambodian provinces in 2010, 2011, and 2012. One married woman of reproductive age who was not pregnant and did not wish to be within the next 2 years in each randomly selected household was approached for inclusion...
February 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28099731/provision-of-harm-reduction-services-to-limit-unsafe-abortion-in-tanzania
#9
Catherine Kahabuka, Andrea Pembe, Alejandra Meglioli
OBJECTIVE: To investigate the feasibility of providing harm-reduction services to reduce unsafe abortion in Tanzania. METHODS: A cross-sectional study was conducted among 110 women who received harm-reduction counseling at a public health center in Dar es Salaam between February 10 and October 10, 2014. Background and clinical information was collected for all women; a subgroup (n=50) undertook a semi-structured survey that measured the type of services women received, women's perception of the services, and pregnancy outcome...
February 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28099728/effects-of-an-intervention-initiated-by-a-national-society-to-improve-postabortion-care-in-rural-facilities-in-burkina-faso
#10
Sibraogo Kiemtoré, Hyacinthe Zamané, Danlotoma P Kaïn, Yobi A Sawadogo, Issa Ouédraogo, Ali Ouédraogo, Jean Lankoandé
OBJECTIVE: To evaluate the results of an intervention by the Societé de Gynécologues et Obstétriciens du Burkina (SOGOB) to improve postabortion care (PAC) in rural areas of Burkina Faso. METHODS: From June 1, 2012, to May 31, 2013, SOGOB increased capacity for PAC by providing training in health care and equipment to 45 rural health facilities. Performance in PAC in the year before intervention (June 1, 2011, to May 31, 2012) was compared with that in the year following intervention (June 1, 2013, to May 31, 2014)...
February 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28099717/maternal-serum-amyloid-a-level-as-a-novel-marker-of-primary-unexplained-recurrent-early-pregnancy-loss
#11
Moustafa I Ibrahim, Ahmed R Ramy, Ahmed S Abdelhamid, Mohamed I Ellaithy, Amna Omar, Rany M Harara, Hayam Fathy, Ashraf S Abolouz
OBJECTIVE: To assess maternal serum amyloid A (SAA) levels among women with primary unexplained recurrent early pregnancy loss (REPL). METHODS: A prospective study was conducted among women with missed spontaneous abortion in the first trimester at Ain Shams University Maternity Hospital, Cairo, Egypt, between January 21 and December 25, 2014. Women with at least two consecutive primary unexplained REPLs and no previous live births were enrolled. A control group was formed of women with no history of REPL who had at least one previous uneventful pregnancy with no adverse outcomes...
December 7, 2016: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28099714/zika-virus-infection-in-brazil-and-human-rights-obligations
#12
Debora Diniz, Sinara Gumieri, Beatriz Galli Bevilacqua, Rebecca J Cook, Bernard M Dickens
The February 2016 WHO declaration that congenital Zika virus syndrome constitutes a Public Health Emergency of International Concern reacted to the outbreak of the syndrome in Brazil. Public health emergencies can justify a spectrum of human rights responses, but in Brazil, the emergency exposed prevailing inequities in the national healthcare system. The government's urging to contain the syndrome, which is associated with microcephaly among newborns, is confounded by lack of reproductive health services. Women with low incomes in particular have little access to such health services...
January 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28099713/systematic-review-of-obstetric-care-from-a-women-centered-perspective-in-nigeria-since-2000
#13
REVIEW
Atsumi Hirose, Oluwatoyin Owolabi, Mari Imamura, Friday Okonofua, Julia Hussein
BACKGROUND: A women-centered approach can improve the quality of patient care. OBJECTIVE: To review issues in the provision of obstetric care from a patient-centered care perspective in Nigeria. SEARCH STRATEGY: Using terms related to maternal and perinatal mortality, in combination with "Nigeria", MEDLINE, Embase, CINAHL, Web of Knowledge, and African Journal Online were searched, between December 1, 2013 and January 31, 2014, for articles in any language...
January 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28099708/association-between-previous-spontaneous-abortion-and-pre-eclampsia-during-a-subsequent-pregnancy
#14
Mahdi Sepidarkish, Amir Almasi-Hashiani, Saman Maroufizadeh, Samira Vesali, Reihaneh Pirjani, Reza O Samani
OBJECTIVE: To determine the impact of a history of spontaneous abortion on pre-eclampsia during a subsequent pregnancy. METHODS: A cross-sectional study enrolled pregnant women admitted to obstetrics and gynecology wards at 103 hospitals in Tehran, Iran for delivery between July 6 and July 21, 2015. Consenting participants were interviewed by midwives; data were collected using a five-part questionnaire and patients' medical records were retrieved. Patient data were analyzed by multiple logistic regression to identify variables associated with increased odds of pre-eclampsia...
January 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28099705/prevalence-of-induced-abortions-and-contraceptive-use-among-married-women-in-an-urban-slum-of-delhi-india
#15
Meenakshi Bhilwar, Panna Lal, Nandini Sharma, Preena Bhalla, Ashok Kumar
OBJECTIVE: To document abortion practices and contraceptive use among women of reproductive age in an urban slum of Delhi. METHODS: Data were collected as part of a cross-sectional study conducted in an urban resettlement colony in the North East District of Delhi between November 2010 and December 2011. Systematic random sampling was used to enroll 200 married women aged 15-49 years from each of the four blocks of the colony. Participants were interviewed and data were entered into a pretested semi-structured questionnaire...
January 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28099696/reaching-vulnerable-women-through-maternity-waiting-homes-in-malawi
#16
Kavita Singh, Ilene Speizer, Eunsoo Timothy Kim, Clara Lemani, Ann Phoya
OBJECTIVE: To determine whether two maternity waiting homes (MWHs) supported by the Safe Motherhood Initiative are reaching vulnerable women during the early phase of their implementation. METHODS: A cross-sectional interview-based study was conducted among women who attended two centers in Malawi with attached MWHs (Area 25 Health Centre, Lilongwe; and Kasungu District Hospital, Kasungu). Between April and June 2015, exit interviews were conducted among MWH users and non-users...
January 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28099695/low-maternal-pregnancy-associated-plasma-protein-a-during-the-first-trimester-of-pregnancy-and-pregnancy-outcomes
#17
Marja Kaijomaa, Leena Rahkonen, Veli-Matti Ulander, Esa Hämäläinen, Henrik Alfthan, Helene Markkanen, Seppo Heinonen, Vedran Stefanovic
OBJECTIVE: To assess the association between pregnancy-associated placental protein A (PAPP-A) levels in the first trimester of pregnancy and adverse pregnancy outcomes. METHOD: A retrospective study included data from a group of patients in the first trimester of pregnancy with PAPP-A levels below 0.3 multiples of median who attended the Helsinki University Hospital, Finland, between January 1, 2009 and December 31, 2012; an age-matched control group of patients with PAPP-A levels 0...
January 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28099690/intimate-partner-violence-and-constraints-to-reproductive-autonomy-and-reproductive-health-among-women-seeking-abortion-services-in-bangladesh
#18
Erin Pearson, Kathryn L Andersen, Kamal Biswas, Rezwana Chowdhury, Susan G Sherman, Michele R Decker
OBJECTIVE: To understand intersections between intimate partner violence (IPV) and other constraints to women's reproductive autonomy, and the influence of IPV on reproductive health. METHODS: A secondary analysis examined cross-sectional data from a facility-based sample of women seeking abortion care (for spontaneous or induced abortion) between March 1 and October 31, 2013. Women aged 18-49 years, who received abortion services and selected a short-acting contraceptive method or no contraception completed an interviewer-administered survey after treatment...
November 25, 2016: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28099685/meta-analysis-comparing-the-safety-of-laparoscopic-and-open-surgical-approaches-for-suspected-adnexal-mass-during-the-second-trimester
#19
REVIEW
Yi-Xuan Liu, Yang Zhang, Jin-Feng Huang, Li Wang
BACKGROUND: The safety of laparoscopic surgery during the second trimester of pregnancy remains a controversial subject. OBJECTIVES: To compare the safety of laparoscopic surgery and laparotomy for suspected adnexal mass during the second trimester. SEARCH STRATEGY: Articles published in any language prior to April 31, 2016, were retrieved from PubMed, Scopus, EMBSCO, and the Cochrane Library using keywords including pregnant, adnexal mass, laparoscopy, laparotomy, pregnancy outcomes, and surgical outcomes...
November 25, 2016: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28099679/clinical-outcomes-for-couples-containing-a-reciprocal-chromosome-translocation-carrier-without-preimplantation-genetic-diagnosis
#20
Biao Yin, Yuanchang Zhu, Tonghua Wu, Shuqiu Shen, Yong Zeng, Desheng Liang
OBJECTIVE: To evaluate the pregnancy outcomes of couples containing a carrier of a reciprocal chromosome translocation (RCT) after assisted reproductive technology without preimplantation genetic diagnosis. METHODS: A retrospective study was performed using data for couples with an RCT carrier and control couples with a normal karyotype (1:4 ratio) who underwent assisted reproductive technology cycles at a Chinese fertility center in 2010-2011. The embryos were fertilized via in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI)...
November 15, 2016: International Journal of Gynaecology and Obstetrics
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