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https://www.readbyqxmd.com/read/28448571/localization-of-adenovirus-morphogenesis-players-together-with-visualization-of-assembly-intermediates-and-failed-products-favor-a-model-where-assembly-and-packaging-occur-concurrently-at-the-periphery-of-the-replication-center
#1
Gabriela N Condezo, Carmen San Martín
Adenovirus (AdV) morphogenesis is a complex process, many aspects of which remain unclear. In particular, it is not settled where in the nucleus assembly and packaging occur, and whether these processes occur in a sequential or a concerted manner. Here we use immunofluorescence and immunoelectron microscopy (immunoEM) to trace packaging factors and structural proteins at late times post infection by either wildtype virus or a delayed packaging mutant. We show that representatives of all assembly factors are present in the previously recognized peripheral replicative zone, which therefore is the AdV assembly factory...
April 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28447484/assessment-of-pain-during-medical-abortion-with-home-use-of-misoprostol
#2
Sandra Cavet, Christian Fiala, Agathe Scemama, Henri Partouche
OBJECTIVES: Although medical abortion with home use of misoprostol has been shown to be safe and acceptable, there are few data about the experience of pain during the procedure. The aims of this study were to assess the intensity of pain associated with home use of misoprostol for medical abortion and to identify variables associated with severe pain. METHODS: This was an observational study using an anonymous web-based questionnaire in patients having a medical abortion at home in France between 1 December 2013 and 30 April 2014...
April 27, 2017: European Journal of Contraception & Reproductive Health Care
https://www.readbyqxmd.com/read/28445268/the-use-of-mifepristone-in-abortion-associated-with-an-increased-risk-of-uterine-leiomyomas
#3
Qi Shen, Li Shu, Hui Luo, Xiaoli Hu, Xueqiong Zhu
To investigate the association between widespread use of mifepristone in abortions and risk of uterine leiomyomas.We conducted a case-control study of 305 patients with uterine leiomyomas between January 2011 and July 2012; 311 women with ordinary vaginitis were selected as controls during the same period. Data were collected by questionnaires (including past history, life history, menstruation history, reproductive history, abortion history, the use of mifepristone, and uterine leiomyomas risk factors) and calculated by univariate and multivariate conditional logistic regression analyses; odds ratios and its 95% confidence interval were calculated to estimate the risk for uterine leiomyomas...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28444557/overview-on-the-current-status-of-zika-virus-pathogenesis-and-animal-related-research
#4
REVIEW
Shashank S Pawitwar, Supurna Dhar, Sneham Tiwari, Chet Raj Ojha, Jessica Lapierre, Kyle Martins, Alexandra Rodzinski, Tiyash Parira, Iru Paudel, Jiaojiao Li, Rajib Kumar Dutta, Monica R Silva, Ajeet Kaushik, Nazira El-Hage
There is growing evidence that Zika virus (ZIKV) infection is linked with activation of Guillan-Barré syndrome (GBS) in adults infected with the virus and microcephaly in infants following maternal infection. With the recent outpour in publications by numerous research labs, the association between microcephaly in newborns and ZIKV has become very apparent in which large numbers of viral particles were found in the central nervous tissue of an electively aborted microcephalic ZIKV-infected fetus. However, the underlying related mechanisms remain poorly understood...
April 25, 2017: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://www.readbyqxmd.com/read/28444434/quantitative-anatomy-of-the-primary-ossification-center-of-the-femoral-shaft-in-human-fetuses
#5
Mariusz Baumgart, Marcin Wiśniewski, Magdalena Grzonkowska, Mateusz Badura, Bogdan Małkowski, Michał Szpinda
PURPOSE: Early clinical distinction of congenital defects in the femur is extremely important, as it determines the prognosis of the development of the lower limb. This study was performed to quantitatively examine the primary center of ossification in the femoral shaft with respect to its linear, planar, and volumetric parameters. MATERIALS AND METHODS: Using methods of CT, digital-image analysis, and statistics, the size of the primary ossification center of the femoral shaft in 47 spontaneously aborted human fetuses aged 17-30 weeks was studied...
April 25, 2017: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/28444176/-j-waves-induced-after-short-coupling-intervals-a-manifestations-of-latent-depolarization-abnormality
#6
Yoshifusa Aizawa, Masafumi Nakayama, Masahito Sato, Masaaki Okabe, Yoshiyasu Aizawa, Seiji Takatsuki, Keiichi Fukuda
Aims: To confirm the presence of tachycardia-induced slur or notch in the terminal portion of the QRS complexes in a general patient population. Methods and results: A tachycardia-induced J wave was defined as a slur or notch in the terminal portion of the QRS complexes newly induced at short RR intervals during atrial premature contractions (APCs) or atrial electrical stimulation in the electrophysiological study (EPS). Twenty-three out of 2000 patients with general diseases were involved...
April 24, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28443481/impact-of-abnormal-dna-methylation-of-imprinted-loci-on-human-spontaneous-abortion
#7
Yudong Liu, Yan Tang, Desheng Ye, Weixu Ma, Shuxian Feng, Xuelan Li, Xingyu Zhou, Xin Chen, Shiling Chen
Currently, there is a growing concern regarding the safety of assisted reproductive technology (ART) due to increased risk of spontaneous abortion (SA) and imprinting disorders in ART-conceived offspring. Early investigations suggested that aberrant genetic imprinting may be related to pregnancy loss; however, few studies have used human tissue specimens. Here the DNA methylation patterns of 3 imprinted genes, including maternally inherited GRB10 and the paternally inherited IGF2 and PEG3 genes, were evaluated in human chorionic villus samples by pyrosequencing and bisulfite sequencing polymerase chain reaction...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28443388/utilization-of-thoracic-ultrasound-for-confirmation-of-central-venous-catheter-placement-and-exclusion-of-pneumothorax-a-novel-technique-in-real-time-application
#8
Dileep Raman, Manish Sharma, Ajit Moghekar, Xiaofeng Wang, Umur Hatipoğlu
AIM: To evaluate the safety and utility of ultrasonography as a tool to confirm central venous catheter (CVC) position and to exclude insertion-related pneumothorax in place of chest radiography (CXR) in a tertiary medical intensive care unit (ICU). METHODS: We randomized 60 consecutive medical ICU patients to conventional or ultrasound groups for CVC placement. Both groups had CVCs inserted under ultrasound guidance. The intervention group underwent real-time transthoracic echocardiography to assist in catheter positioning and chest ultrasonography for exclusion of pneumothorax...
January 1, 2017: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/28443127/transcriptome-analysis-of-a-female-sterile-mutant-fsm-in-chinese-cabbage-brassica-campestris-ssp-pekinensis
#9
Shengnan Huang, Zhiyong Liu, Chengyu Li, Runpeng Yao, Danyang Li, Li Hou, Xiang Li, Wenjie Liu, Hui Feng
Female-sterile mutants are ideal materials for studying pistil development in plants. Here, we identified a female-sterile mutant fsm in Chinese cabbage. This mutant, which exhibited stable inheritance, was derived from Chinese cabbage DH line 'FT' using a combination of isolated microspore culture and ethyl methanesulfonate mutagenesis. Compared with the wild-type line 'FT,' the fsm plants exhibited pistil abortion, and floral organs were also relatively smaller. Genetic analysis indicated that the phenotype of fsm is controlled by a single recessive nuclear gene...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28442797/pre-and-post-sexual-exposure-prophylaxis-of-hiv-an-update
#10
REVIEW
Yogesh S Marfatia, Sheethal K Jose, Reema R Baxi, Ruchi J Shah
Pitfalls in current HIV prevention strategies include late HIV testing, vulnerability among youth and females; lack of emphasis on treatment, low acceptance of circumcision, and nonavailability of protective vaccines. Continuing high-risk sexual behavior, forceful sex, coercive and nonconsensual sex, rape, and unprotected sexual activities make women the most vulnerable to acquisition of sexually transmitted infection/HIV and necessitates a more radical approach of prevention in high-risk individuals who do not have HIV...
January 2017: Indian Journal of Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28442485/citizens-assembly-recommends-unrestricted-access-to-abortion-in-ireland
#11
Gareth Iacobucci
No abstract text is available yet for this article.
April 25, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28442189/exploring-how-residents-who-partially-participate-in-family-planning-training-determine-their-level-of-participation
#12
Jema K Turk, Felisa Preskill, Alecia Fields, Uta Landy, Jody E Steinauer
OBJECTIVES: The Accreditation Council for Graduate Medical Education (ACGME) requires that obstetrics and gynecology residency programs provide access to abortion training, though residents may elect to opt out of participating due to religious or moral objections. While clinical benefits of partial participation have previously been explored, our study aimed to explore how residents navigate partial participation in abortion training and determine their limits. STUDY DESIGN: This study was qualitative in nature...
April 22, 2017: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
https://www.readbyqxmd.com/read/28441992/safety-of-a-c1-inhibitor-concentrate-in-pregnant-women-with-hereditary-angioedema
#13
James Fox, Arthur B Vegh, Inmaculada Martinez-Saguer, Walter A Wuillemin, Jonathan Edelman, Debora Williams-Herman, Mikhail Rojavin, Tanja Rosenberg
BACKGROUND: Increased estrogen levels during pregnancy can exacerbate hereditary angioedema (HAE), yet disease and treatment ramifications remain poorly studied in pregnant women. OBJECTIVE: Data from the international Berinert Patient Registry were used to evaluate outcomes of pregnancies exposed to plasma-derived, pasteurized, nanofiltered C1-inhibitor concentrate (pnfC1-INH) during routine HAE management. METHODS: This observational registry, conducted between 2010 and 2014 at 30 U...
May 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28441941/effect-of-previous-utilization-and-out-of-pocket-expenditure-on-subsequent-utilization-of-a-state-led-public-private-partnership-scheme-chiranjeevi-yojana-to-promote-facility-births-in-gujarat-india
#14
Sandul Yasobant, Hemant Deepak Shewade, Kranti Suresh Vora, Kristi Sidney Annerstedt, Petros Isaakidis, Nishith B Dholakia, Dileep V Mavalankar
BACKGROUND: In Gujarat, India, a state led public private partnership scheme to promote facility birth named Chiranjeevi Yojana (CY) was implemented in 2005. Institutional birth is provided free of cost at accredited private health facilities to women from socially disadvantaged groups (eligible women). CY has contributed in increasing facility birth and providing substantially subsidized (but not totally free) birth care; however, the retention of mothers in this scheme in subsequent child birth is unknown...
April 25, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28441100/women-s-health-as-an-ideological-and-political-issue-restricting-the-right-to-abortion-access-to-in-vitro-fertilization-procedures-and-prenatal-testing-in-poland
#15
Piotr Żuk, Paweł Żuk
The authors describe the problems of women in Poland, who have limited access to abortion, in vitro fertilization procedures and prenatal tests. The current situation stems from ideological pressure which affects women's health issues. This is part of a broader syndrome of the conservative approach to women's health in Eastern Europe, as well as the factor that strengthens the extreme right in Europe. As women's sexual health is demonized, women less often undergo preventive examinations. Making the debate about health more rational requires radical socio-cultural changes in this part of the world...
April 25, 2017: Health Care for Women International
https://www.readbyqxmd.com/read/28440862/a-large-intrauterine-vascular-lesion-developing-after-the-successful-treatment-of-a-cesarean-scar-pregnancy-with-methotrexate-injection
#16
Ji Won Song, Da Hye Ju, Sang Wook Yi, Joo Hee Lee, Woo Seok Sohn, Sang Soo Lee
A cesarean scar pregnancy is a rare type of ectopic pregnancy. Induced abortion by local methotrexate (MTX) injection is an effective management approach. We describe a case in which a large intrauterine vascular lesion appeared after the sonographic-guided local injection of MTX, which successfully induced the abortion of the cesarean scar pregnancy. Although a cesarean scar pregnancy may be safely treated with a local MTX injection, close follow-up, including serum β-human chorionic gonadotropin level measurement and Doppler sonography, is needed because an intrauterine vascular lesion could develop even after a successfully induced abortion...
April 25, 2017: Journal of Clinical Ultrasound: JCU
https://www.readbyqxmd.com/read/28439851/exploring-the-pathophysiology-of-takotsubo-cardiomyopathy
#17
REVIEW
Wengen Chen, Vasken Dilsizian
PURPOSE OF REVIEW: The purpose of this review is to explore the pathophysiology of Takotsubo cardiomyopathy by appraising the interplay between myocardial perfusion, function, metabolism, and, particularly, sympathetic innervation. RECENT FINDINGS: A number of hypotheses have been proposed to explain the pathogenesis of Takotsubo cardiomyopathy, which include (1) catecholamine cardiac toxicity, (2) myocardial sympathetic innervation disruption, (3) coronary vasospasm, (4) myocardial microvascular dysfunction, and (5) aborted myocardial infarction...
June 2017: Current Cardiology Reports
https://www.readbyqxmd.com/read/28439710/application-of-gold-nanoparticle-assisted-pcr-for-equine-herpesvirus-1-diagnosis-in-field-samples
#18
Dalia M El-Husseini, Nashwa M Helmy, Reham H Tammam
Equine herpesvirus 1 (EHV-1) is one of the most significant pathogens that affects equine species worldwide, causing sporadic abortion, neonatal deaths, chorioretinopathy, as well as neurological and upper respiratory tract diseases. Currently, conventional PCR targeting different genes is used widely for the molecular detection of EHV-1, but the low viral titer in some clinical samples can lead to false negative results. In this study, we aimed to assess gold nanoparticle (GNP)-assisted PCR as an inexpensive, highly efficient, and sensitive method for the detection of EHV-1, and to compare its results with conventional PCR and real-time quantitative PCR (qPCR)...
April 24, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28438095/arcobacter-an-emerging-food-borne-zoonotic-pathogen-its-public-health-concerns-and-advances-in-diagnosis-and-control-a-comprehensive-review
#19
Thadiyam Puram Ramees, Kuldeep Dhama, Kumaragurubaran Karthik, Ramswaroop Singh Rathore, Ashok Kumar, Mani Saminathan, Ruchi Tiwari, Yashpal Singh Malik, Raj Kumar Singh
Arcobacter has emerged as an important food-borne zoonotic pathogen, causing sometimes serious infections in humans and animals. Newer species of Arcobacter are being incessantly emerging (presently 25 species have been identified) with novel information on the evolutionary mechanisms and genetic diversity among different Arcobacter species. These have been reported from chickens, domestic animals (cattle, pigs, sheep, horses, dogs), reptiles (lizards, snakes and chelonians), meat (poultry, pork, goat, lamb, beef, rabbit), vegetables and from humans in different countries...
April 25, 2017: Veterinary Quarterly
https://www.readbyqxmd.com/read/28433733/factors-influencing-repeated-teenage-pregnancy-a-review-and-meta-analysis
#20
REVIEW
Joemer C Maravilla, Kim S Betts, Camila Couto E Cruz, Rosa Alati
OBJECTIVE: Existing evidence of predictors of repeated teenage pregnancy (RTP) has not been rigorously assessed. This systematic review provides a comprehensive evaluation of protective and risk factors associated with RTP through a meta-analytical consensus. DATA SOURCES: Pubmed, EMBASE, CINAHL, ProQuest, PsychINFO, ScienceDirect, Scopus and Web of Science databases, from 1997 to 2015; and reference list of other relevant research papers and related reviews. STUDY ELIGIBILITY CRITERIA: Eligibility criteria included 1) epidemiological studies which analysed factors associated with repeated pregnancy or birth among adolescents under 20 years of age who were nulliparous or experienced at least one pregnancy; 2) experimental studies with an observational component adjusted for the intervention...
April 19, 2017: American Journal of Obstetrics and Gynecology
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