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Yue Shi, Bin Zhang, Fanbin Kong, Xilian Li
To analyze prenatal ultrasound data for fetal limb deformities in high-risk pregnant women and the risk factors for prenatal limb defects in high-risk pregnant women.This was a retrospective study of high-risk pregnant women at the multidisciplinary consultation center from January 2006 to December 2015. When deformities were definitively diagnosed in the first trimester by ultrasound, patients were recommended to undergo an abortion, and fetal abnormalities were confirmed by pathological examination (both gross anatomic examinations and fetal chromosome and genetic tests)...
July 2018: Medicine (Baltimore)
Sook Ryung Kim, Eun Jung Choi, Young Joo Kim, Tae Yoon Kim, Young Jin Lee
Although trisomy 16 is commonly detected in spontaneous abortions and accounts for over 30% of cases of autosomal trisomy detected after spontaneous abortion, trisomy 16 mosaicism is rarely detected by amniocentesis in the second trimester. Here, we report a case of level III trisomy 16 mosaicism (47,XX,+16[8]/46,XX[31]) diagnosed by cytogenetic analysis of independently cultured amniotic fluid cells. The female baby was delivered at full term with low birth weight and intrauterine growth retardation, and interestingly, her karyotype was normal (46,XX)...
June 2018: Balsaeng'gwa Saengsig
Jianlong Liu, Rui Zhai, Fengxia Liu, Yingxiao Zhao, Huibin Wang, Lulu Liu, Chengquan Yang, Zhigang Wang, Fengwang Ma, Lingfei Xu
Parthenocarpy, the production of seedless fruit without fertilization, has a variety of valuable qualities, especially for self-incompatible species, such as pear. To explore whether melatonin (MT) induces parthenocarpy, we used 'Starkrimson' pear as a material for morphological observations. According to our results, exogenous MT promoted the expansion and division of the mesocarp cells in a manner similar to hand pollination. However, the seeds of exogenous MT-treated fruit were undeveloped and aborted later in the fruit-setting stage...
2018: Frontiers in Plant Science
Nadine Wentzell, Tania Schink, Ulrike Haug, Sandra Ulrich, Marieke Niemeyer, Rafael Mikolajczyk
PURPOSE: For studying drug utilization and safety in pregnancy based on administrative health care data, the reliable identification and classification of pregnancy outcomes in the data is essential. We aimed to optimize an existing algorithm for the identification and classification of pregnancy outcomes in the German Pharmacoepidemiological Research Database (GePaRD) with a particular focus on births. METHODS: We reconsidered all codes used by the original algorithm and applied it to data of GePaRD from 2006 to 2014...
July 18, 2018: Pharmacoepidemiology and Drug Safety
Dane R Van Domelen, Emily M Mitchell, Neil J Perkins, Enrique F Schisterman, Amita K Manatunga, Yijian Huang, Robert H Lyles
In a multivariable logistic regression setting where measuring a continuous exposure requires an expensive assay, a design in which the biomarker is measured in pooled samples from multiple subjects can be very cost effective. A logistic regression model for poolwise data is available, but validity requires that the assay yields the precise mean exposure for members of each pool. To account for errors, we assume the assay returns the true mean exposure plus a measurement error (ME) and/or a processing error (PE)...
July 18, 2018: Statistics in Medicine
Łukasz Olewnik, Anna Waśniewska, Michał Polguj, Michał Podgórski, Piotr Łabętowicz, Kacper Ruzik, Mirosław Topol
PURPOSE: The palmaris longus (PL) muscle is characterized by high-morphological variability. It is clinically important as it is routinely harvested for the reconstruction of other tendons. The study characterizes the morphology of the PL in human fetuses and creates a new classification based on its variations that would relate to the spectrum of morphological variability in adults. METHODS: Eighty spontaneously aborted human foetuses (44 male, 36 female, 160 upper limbs), aged 18-38 weeks of gestation, were examined...
July 18, 2018: Surgical and Radiologic Anatomy: SRA
Gary R Lichtenstein, Brian G Feagan, Uma Mahadevan, Bruce A Salzberg, Wayne Langholff, G James Morgan, Michael Safdi, Riikka Nissinen, François Taillard, William J Sandborn, Russell D Cohen
OBJECTIVES: We described pregnancy outcomes in Crohn's disease (CD) patients enrolled in the TREAT Registry who received infliximab before, or during pregnancy and those not treated with infliximab or any biologic agent. METHODS: In the TREAT Registry (1999-2012), pregnancy outcomes were analyzed from maternal and paternal patients exposed to infliximab ≤365 days (gestational exposure), >365 days (pre-gestational exposure) of pregnancy outcome or without infliximab exposure (non-biologic exposed)...
July 19, 2018: American Journal of Gastroenterology
Elizabeth A Caves, Sarah A Cook, Nara Lee, Donna Stoltz, Simon Watkins, Kathy H Y Shair
Epstein-Barr virus (EBV) is a ubiquitous gammaherpesvirus that establishes a latent reservoir in peripheral B-lymphocytes with sporadic reactivation. EBV also infects epithelial cells, predominantly resulting in a lytic infection, which may contribute to EBV transmission from saliva. In the nasopharynx, EBV infection can lead to the clonal expansion of a latently infected cell and the development of nasopharyngeal carcinoma (NPC). The mechanisms governing EBV pathogenesis in nasopharyngeal epithelium are largely unknown...
July 18, 2018: MSphere
Caitlin Gerdts, Ruvani T Jayaweera, Sarah E Baum, Inna Hudaya
INTRODUCTION: Unsafe abortion past the first trimester disproportionately accounts for the majority of global abortion-related morbidity and mortality; research that documents the safety, feasibility and acceptability of existing models for providing information and support to women who self-manage outside of formal clinic settings is needed. METHODS: This study is a retrospective analysis of anonymised electronic client records from callers to a safe abortion hotline in Indonesia...
July 18, 2018: BMJ sexual & reproductive health
Elizabeth M Stringer, Michelle A Kendall, Shahin Lockman, Thomas B Campbell, Karin Nielsen-Saines, Fred Sawe, Susan Cu-Uvin, Xingye Wu, Judith S Currier
As antiretroviral therapy (ART) expands in resource-limited settings, understanding the impact of ART on pregnancy outcomes is critical. We analyzed women who became pregnant on ART while enrolled in a clinical trial (HPTN 052, ACTG A5208, and ACTG A5175); the majority of women were from Africa, with a median age of 29 years. Eligible women were on ART at conception and had a documented date of a last menstrual period and a pregnancy outcome. The primary outcome was non-live birth (stillbirth; spontaneous abortion; elective termination; or ectopic pregnancy) versus live birth...
2018: PloS One
Hongyu Chen, Shuqin Li, Lu Li, Weiying Wu, Xiaolong Ke, Wenxuan Zou, Jie Zhao
The endosperm and embryo originate from the fertilized central cell and egg cell through a programmed series of cell division and differentiation events. Characterization of more vital genes involved in endosperm and embryo development can help us to deeply understand the regulatory mechanism. In this study, we found loss of NAA10 and NAA15, the catalytic and auxiliary subunit of Arabidopsis thaliana N-terminal acetyltransferase A (AtNatA), led to severely delayed and incomplete endosperm cellularization, accompanied with disordered cell division in early embryo...
July 18, 2018: Plant & Cell Physiology
Susan M Seav, Nathaniel M Schuster
Background There are cases in the headache literature described as "cluster-migraine," but none of stereotyped cases of cluster headache evolving into status migrainosus. We believe this is the first documented case of "cluster-status migrainosus". Case A 54 year-old female hospital administrator presented with headaches with a unique periodicity and semiology that were acutely responsive to high-flow oxygen. She experienced cluster headache attacks every Thursday morning at 3-4 am, which would evolve into status migrainosus lasting through Sunday evening...
January 1, 2018: Cephalalgia: An International Journal of Headache
Yuyeon Jung, Ah Ra Lee, Sung-Jong Lee, Yong Seok Lee, Dong Choon Park, Eun Kyung Park
Objective: This study aimed to determine the factors affecting pathologic discrepancy and final diagnosis between colposcopic biopsy and pathology by loop electrosurgical excision procedure (LEEP). Methods: Between 2004 and 2016, 1,200 patients who underwent LEEP were enrolled for this study. 667 underwent cervical cytology, human papillomavirus (HPV) test, colposcopic biopsy, and LEEP. We analyzed patient's age, menopausal status, number of delivery, abortion times, cervical cytology, number of punch biopsies, HPV type, LEEP, and interval between colposcopic biopsy and LEEP...
July 2018: Obstetrics & Gynecology Science
Alberto Kornblihtt
No abstract text is available yet for this article.
July 2018: Nature
Ke Wang, Zong-Li Guo, Wen-Tao Zhou, Cheng Zhang, Ze-Yuan Zhang, Yue Lou, Shuang-Xi Xiong, Xiaozhen Yao, Jiong-Jiong Fan, Jun Zhu, Zhong-Nan Yang
The outer pollen wall (sexine) protects pollen and contains sporopollenin, which is synthesized using a pathway of approximately eight genes in Arabidopsis thaliana. MALE STERILITY 188 (MS188) and its direct upstream regulator ABORTED MICROSPORES (AMS) are two transcription factors essential for tapetum development. Here, we show that all the sporopollenin biosynthesis proteins are specifically expressed in the tapetum and are secreted into anther locules. MS188, a MYB transcription factor expressed in the tapetum, directly regulates the expression of POLYKETIDE SYNTHASE A (PKSA), PKSB, MALE STERILE2 (MS2), and a CYTOCHROME P450 gene (CYP703A2)...
July 17, 2018: Plant Physiology
Stephan Scherneck, Natalie Schlinke, Evelin Beck, Katharina Grupe, Corinna Weber-Schoendorfer, Christof Schaefer
The aim of this study was to evaluate the risk of major birth defects and spontaneous abortion after metformin use during the first trimester of pregnancy. We conducted an observational cohort study comparing pregnancies with metformin treatment during the first trimester with non-exposed women matched for BMI and year of enrolment. Pregnancies were prospectively ascertained in the German Embryotox pharmacovigilance database between 2004 and 2014. The study sample included 336 pregnancies with metformin exposure for PCOS and fertility disorders (56...
July 11, 2018: Reproductive Toxicology
Tomas Zaremba, Anders Krogh Brøndberg, Henrik Kjærulf Jensen, Won Yong Kim
PURPOSE: We aimed to identify and assess cardiac abnormalities by cardiovascular magnetic resonance (CMR) in a non-ischaemic aborted sudden cardiac death (SCD) population and to establish possible predictors of SCD. METHODS: Thirty-six consecutive SCD survivors [median age 37.6 years (IQR 24.1-43.2), 31% female] with no previous cardiac history or evidence of ischaemic heart disease underwent CMR on day 6 (IQR 4-10) after admission. Data on ventricular volumes and the extent of late gadolinium enhancement (LGE) were collected...
August 2018: European Journal of Radiology
M Rahal, D Tahir, C Eldin, I Bitam, D Raoult, P Parola
Coxiella burnetii, is an obligate intracellular bacterium which is present throughout the world. In humans, C. burnetii is the causative agent of Q fever. In cattle, the infection is suspected to cause stillbirths, retained fetal membranes, metritis and infertility. The birth products of ruminants shed huge amounts of bacteria, and are considered a major source for human infection. The present study was designed to search for the presence of C. burnetii in placental tissues collected from aborted and normal calving dairy cows in Algeria, using molecular tools...
April 2018: Comparative Immunology, Microbiology and Infectious Diseases
Md Nazmul Ahsan, Riddhi Maharaj
Health at birth shapes an individual's well-being over her life cycle. We categorize the Indian states into high and low infant mortality regions to capture the diverse disease environment and analyze the nature of the association between parental human capital and child survival and nutrition measures at birth. We restrict our analysis only to firstborns to avoid confounding from a number of factors including sex-selective abortions in the higher birth orders. We broadly find that parental human capital, especially maternal health, is a strong and significant predictor of a child's birth outcomes under adverse disease environment...
June 30, 2018: Economics and Human Biology
Shane A Kavanagh, Julia M Shelley, Christopher Stevenson
Theoretical approaches suggest that gender inequity increases men's health risks. Previous findings from the United States support this contention, however only a small number of health outcomes have been explored. This study extends the range of health outcomes examined by using a cross-sectional, multilevel analysis to investigate whether measures of state-level gender inequity are predictors of men's self-rated health. Data were derived primarily from the Behavioral Risk Factor Surveillance System and the full-case data set included 116,594 individuals nested within 50 states...
2018: PloS One
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