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https://www.readbyqxmd.com/read/28943148/in-vivo-safety-evaluation-of-antibacterial-silver-chloride-nanoparticles-from-streptomyces-exfoliatus-icn25-in-zebrafish-embryos
#1
Appadurai Muthamil Iniyan, Rajaretinam Rajesh Kannan, Francis-Joseph Rosemary Sharmila Joseph, Thankaraj Rajam Jabila Mary, Mani Rajasekar, Puthenpurayil Chellappan Sumy, Arul Maximus Rabel, Dasnamoorthy Ramachandran, Samuel Gnana Prakash Vincent
Silver chloride nanoparticles were synthesized from the cell-free culture supernatant of Streptomyces strain using green synthesis approach with good yield. The nanoparticles were characterized by UV-Vis, IR, SEM, AFM and XRD techniques. These nanoparticles exhibited broad spectrum of antibacterial activity towards Methicillin-resistant Staphylococcus aureus, Methicillin sensitive S. aureus, Escherichia coli, Pseudomonas aeruginosa and Klebsiella pneumonia at ≤ 2 μg/ml minimal inhibitory concentrations...
September 21, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28942778/psychometric-evaluation-of-the-hospital-culture-of-transitions-survey
#2
Mark McClelland, James Bena, Nancy M Albert, Jesse M Pines
BACKGROUND: Ineffective or inefficient transitions threaten patient safety, hinder communication, and worsen patient outcomes. The Hospital Culture of Transitions (H-CulT) survey was designed to assess a hospital's organizational culture related to within-hospital transitions in care involving patient movement. In this article, psychometric properties of the H-CulT survey were examined to assess and refine the hospital culture of transitions. METHODS: A cross-sectional, multicenter, multidisciplinary correlational design and survey methods were used to examine the psychometric properties of the H-CulT survey...
October 2017: Joint Commission Journal on Quality and Patient Safety
https://www.readbyqxmd.com/read/28940765/consensus-achievement-of-leadership-organisational-and-individual-factors-that-influence-safety-climate-implications-for-nursing-management
#3
Shelly A Fischer, Jacqueline Jones, Joyce A Verran
AIM: To validate a framework of factors that influence the relationship of transformational leadership and safety climate, and to enable testing of safety chain factors by generating hypotheses regarding their mediating and moderating effects. BACKGROUND: Understanding the patient safety chain and mechanisms by which leaders affect a strong climate of safety is essential to transformational leadership practice, education, and research. METHODS: A systematic review of leadership and safety literature was used to develop an organising framework of factors proposed to influence the climate of safety...
September 21, 2017: Journal of Nursing Management
https://www.readbyqxmd.com/read/28940247/enhancing-patient-safety-in-the-operating-theatre-from-the-perspective-of-experienced-operating-theatre-nurses
#4
Eydis Ingvarsdottir, Sigridur Halldorsdottir
THE STUDY'S RATIONALE: Surgical care is an extensive component of modern health care, but patient safety issues and complications of surgery have been identified as a major cause of death and disability. OBJECTIVE: The aim of this study was to identify, from the perspective of experienced operating theatre nurses (OTNs), how patient safety in the operating theatre (OT) can be enhanced. RESEARCH METHODOLOGY AND METHODS: In this phenomenological study, 14 individual interviews were conducted with a purposive sample of 11 participants: ten women and one man...
September 22, 2017: Scandinavian Journal of Caring Sciences
https://www.readbyqxmd.com/read/28940212/no-induced-mutagenesis-in-human-lymphoblast-cell-line-and-bacterial-systems-upon-their-prolonged-sub-culturing-in-irradiated-food-blended-media
#5
Sudhanshu Saxena, Sanjeev Kumar, Jyoti Tripathi, Satyendra Gautam
BACKGROUND: Confound apprehension towards safety of irradiated food has remained a major cause behind tardy acceptance of this technology though it has immense socio-economic potential. Generation of in depth scientific evidences will help to refute these apprehensions. With this prospective, present study was undertaken where safety of various irradiated (Dmin up to 25 kGy) foods was evaluated through long term exposure studies in models including human lymphoblast TK6 cell line (100 generations) and Escherichia coli MG1655 cells (exclusive subcuturing in irradiated food medium for 3000 generations)...
September 20, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28938891/treatment-of-lumbar-degenerative-disc-disease-associated-radicular-pain-with-culture-expanded-autologous-mesenchymal-stem-cells-a-pilot-study-on-safety-and-efficacy
#6
Christopher Centeno, Jason Markle, Ehren Dodson, Ian Stemper, Christopher J Williams, Matthew Hyzy, Thomas Ichim, Michael Freeman
BACKGROUND: Degenerative disc disease (DDD) is a common cause of lower back pain with radicular symptoms and has a significant socioeconomic impact given the associated disability. Limited effective conservative therapeutic options result in many turning to surgical alternatives for management, which vary in the rate of success and also carry an increased risk of morbidity and mortality associated with the procedures. Several animal based studies and a few human pilot studies have demonstrated safety and suggest efficacy in the treatment of DDD with mesenchymal stem cells (MSCs)...
September 22, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28938300/enhancing-the-quality-and-safety-of-the-perioperative-patient
#7
Sven Staender, Andrew Smith
PURPOSE OF REVIEW: Many possible hazards bedevil the perioperative patient. This review focuses on a number of aspects of perioperative management where the patient's quality and safety can be enhanced. RECENT FINDINGS: Our understanding of the relationship between preoperative preparation and postoperative outcomes has improved. There have also been recent developments in our understanding of how to construct useful cognitive aids and make the best use of checklists by understanding the cultural environment supporting their use...
September 21, 2017: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/28936776/brettanomyces-bruxellensis-yeasts-impact-on-wine-and-winemaking
#8
REVIEW
Monica Agnolucci, Antonio Tirelli, Luca Cocolin, Annita Toffanin
Yeasts belonging to the Brettanomyces/Dekkera genus are non-conventional yeasts, which affect winemaking by causing wine spoilage all over the world. This mini-review focuses on recent results concerning the presence of Brettanomyces bruxellensis throughout the wine processing chain. Here, culture-dependent and independent methods to detect this yeast on grapes and at the very early stage of wine production are encompassed. Chemical, physical and biological tools, devised for the prevention and control of such a detrimental species during winemaking are also presented...
September 21, 2017: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/28936475/surgical-data-science-the-new-knowledge-domain
#9
S Swaroop Vedula, Gregory D Hager
Healthcare in general, and surgery/interventional care in particular, is evolving through rapid advances in technology and increasing complexity of care with the goal of maximizing quality and value of care. While innovations in diagnostic and therapeutic technologies have driven past improvements in quality of surgical care, future transformation in care will be enabled by data. Conventional methodologies, such as registry studies, are limited in their scope for discovery and research, extent and complexity of data, breadth of analytic techniques, and translation or integration of research findings into patient care...
April 2017: Innov Surg Sci
https://www.readbyqxmd.com/read/28936111/agile-development-of-a-smartphone-app-for-perinatal-monitoring-in-a-resource-constrained-setting
#10
Boris Martinez, Rachel Hall-Clifford, Enma Coyote, Lisa Stroux, Camilo E Valderrama, Christopher Aaron, Aaron Francis, Cate Hendren, Peter Rohloff, Gari D Clifford
Technology provides the potential to empower frontline healthcare workers with low levels of training and literacy, particularly in low- and middle-income countries. An obvious platform for achieving this aim is the smartphone, a low cost, almost ubiquitous device with good supply chain infrastructure and a general cultural acceptance for its use. In particular, the smartphone offers the opportunity to provide augmented or procedural information through active audiovisual aids to illiterate or untrained users, as described in this article...
2017: Journal of Health Informatics in Developing Countries
https://www.readbyqxmd.com/read/28935568/genetically-engineered-oncolytic-newcastle-disease-virus-mediates-cytolysis-of-prostate-cancer-stem-like-cells
#11
Shobana Raghunath, Raghavendra Sumanth Pudupakam, Adria Allen, Moanaro Biswas, Nammalwar Sriranganathan
Oncolytic virotherapy is a promising novel approach that overcomes the limitations posed by radiation and chemotherapy. In this study, the oncolytic efficacy of a recombinant Newcastle disease virus (rNDV) BC-KLQL-GFP, against prostate cancer stem-like/tumor initiating cells was evaluated. Xenograft derived prostaspheres (XPS) induced tumor more efficiently than monolayer cell derived prostaspheres (MCPS) in nude mice. Primary and secondary XPS show enhanced self-renewal and clonogenic potential compared to MCPS...
September 19, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28933639/violence-prevention-community-meeting-conducted-on-your-unit
#12
Marilyn L Lanza
The Violence Prevention Community Meeting (VPCM) is to reduce violence on inpatient psychiatry units, and has been written about elsewhere. The purpose of this article is to explain how other nurses can implement a similar meeting in their work setting. Details of different aspects of the VPCM are provided including the purpose, administrative support role of patients and staff, and the content and process of the VPCM. The reader is presented with several different scenarios about assault. The VPCM is an innovative, group-based treatment, administered by nursing staff members...
September 21, 2017: Issues in Mental Health Nursing
https://www.readbyqxmd.com/read/28932818/impact-of-cell-culture-parameters-on-production-and-vascularization-bioactivity-of-mesenchymal-stem-cell-derived-extracellular-vesicles
#13
Divya B Patel, Kelsey M Gray, Yasasvhinie Santharam, Tek N Lamichhane, Kimberly M Stroka, Steven M Jay
Mesenchymal stem cell (MSC)-derived extracellular vesicles (EVs) have emerged as potential therapeutic agents for numerous applications. EVs offer potential advantages over cell-based therapies with regard to safety, stability and clearance profiles, however production and potency limitations must be addressed to enable eventual translation of EV-based approaches. Thus, we sought to examine the role of specific cell culture parameters on MSC EV production and bioactivity toward informing rational design parameters for scalable EV biomanufacturing...
June 2017: Bioengineering & Translational Medicine
https://www.readbyqxmd.com/read/28931834/mild-hypothermia-provides-treg-stability
#14
Marek- Trzonkowska Natalia, Piekarska Karolina, Filipowicz Natalia, Piotrowski Arkadiusz, Gucwa Magdalena, Vogt Katrin, Sawitzki Birgit, Siebert Janusz, Trzonkowski Piotr
Regulatory T cells (Tregs) play crucial role in maintenance of peripheral tolerance. Recent clinical trials confirmed safety and efficacy of Treg treatment of deleterious immune responses. However, Tregs lose their characteristic phenotype and suppressive potential during expansion ex vivo. Therefore, multiple research teams have been studding Treg biology in aim to improve their stability in vitro. In the current paper, we demonstrate that mild hypothermia of 33 °C induces robust proliferation of Tregs, preserves expression of FoxP3, CD25 and Helios, and prevents TSDR methylation during culture in vitro...
September 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28931827/altered-methylations-of-h19-snrpn-mest-and-peg3-are-reversible-by-developmental-reprogramming-in-kidney-tissue-of-icsi-derived-mice
#15
Qitao Zhan, Xuchen Qi, Ning Wang, Fang Le, Luna Mao, Xinyun Yang, Mu Yuan, Hangying Lou, Xiangrong Xu, Xijing Chen, Fan Jin
Although the prevalence of Intracytoplasmic sperm injection (ICSI) has increased year by year, there remains concern about the safety of these procedures because of reports of the increased risk for imprinting disorders. Previous research has demonstrated that gonadotropin stimulation contributes to an increased incidence of epimutations in ICSI-derived mice. However, the epimutations in ICSI offspring after removing the effect of gonadotropin stimulation and the possibility that epimutations are reversible by developmental reprogramming has not been investigated...
September 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28931383/evaluation-of-caregiver-friendly-workplace-policy-cfwps-interventions-on-the-health-of-full-time-caregiver-employees-ces-implementation-and-cost-benefit-analysis
#16
Allison M Williams, Emile Tompa, Donna S Lero, Janet Fast, Amin Yazdani, Isik U Zeytinoglu
BACKGROUND: Current Canadian evidence illustrating the health benefits and cost-effectiveness of caregiver-friendly workplace policies is needed if Canadian employers are to adopt and integrate caregiver-friendly workplace policies into their employment practices. The goal of this three-year, three study research project is to provide such evidence for the auto manufacturing and educational services sectors. The research questions being addressed are: What are the impacts for employers (economic) and workers (health) of caregiver-friendly workplace policy intervention(s) for full-time caregiver-employees? What are the impacts for employers, workers and society of the caregiver-friendly workplace policy intervention(s) in each participating workplace? What contextual factors impact the successful implementation of caregiver-friendly workplace policy intervention(s)? METHODS: Using a pre-post-test comparative case study design, Study A will determine the effectiveness of newly implemented caregiver-friendly workplace policy intervention(s) across two workplaces to determine impacts on caregiver-employee health...
September 20, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28930669/a-highly-specific-escherichia-coli-qpcr-and-its-comparison-with-existing-methods-for-environmental-waters
#17
David I Walker, Jonathan McQuillan, Michael Taiwo, Rachel Parks, Craig A Stenton, Hywel Morgan, Matthew C Mowlem, David N Lees
The presence of Escherichia coli in environmental waters is considered as evidence of faecal contamination and is therefore commonly used as an indicator in both water quality and food safety analysis. The long period of time between sample collection and obtaining results from existing culture based methods means that contamination events may already impact public health by the time they are detected. The adoption of molecular based methods for E. coli could significantly reduce the time to detection. A new quantitative real-time PCR (qPCR) assay was developed to detect the ybbW gene sequence, which was found to be 100% exclusive and inclusive (specific and sensitive) for E...
August 25, 2017: Water Research
https://www.readbyqxmd.com/read/28930638/use-of-telehealth-for-health-care-of-indigenous-peoples-with-chronic-conditions-a-systematic-review
#18
Sarah Fraser, Tamara Mackean, Julian Grant, Kate Hunter, Kurt Towers, Rebecca Ivers
INTRODUCTION: Telehealth may be a cost effective modality in healthcare delivery, but how well used or how appropriate it is for the care of Indigenous peoples is unclear. This review examines the evidence for telehealth in facilitating chronic conditions management with Indigenous peoples. METHODS: Databases were systematically searched for qualitative or quantitative primary research studies that investigated telehealth use for chronic conditions management with Indigenous peoples worldwide...
July 2017: Rural and Remote Health
https://www.readbyqxmd.com/read/28929881/high-reliability-in-healthcare-creating-the-culture-and-mindset-for-patient-safety
#19
Bonnie S Cochrane, Mitch Hagins, Gino Picciano, John A King, David A Marshall, Brian Nelson, Craig Deao
Occurrences of patient harm in healthcare represent a significant burden, with serious implications for patients and families and for the capacity of health systems to manage patient access, flow, and wait times. Interest in the science of high reliability, developed originally in industries such as commercial airlines that have demonstrated exceptional safety records, is an emerging trend in healthcare with the potential to help organizations and systems achieve the ultimate goal of zero patient harm. This article argues that zero patient harm is a fundamental imperative, and that high-reliability science can help to accelerate and sustain progress toward this vital goal...
March 2017: Healthcare Management Forum
https://www.readbyqxmd.com/read/28929877/cultural-safety-and-engagement-keys-to-improving-access-to-care
#20
Justin Ringer
The challenges of providing equitable and timely access to high-quality care are numerous, and the proposed solutions are well documented. However, frequently absent from discussions dealing with access to care is how access is being defined and by whom. This article demonstrates the importance of engaging individuals and communities when defining access and developing improvement strategies, and the experience of an Indigenous regional health and social services authority.
July 2017: Healthcare Management Forum
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