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https://www.readbyqxmd.com/read/29141316/-a-clinical-analysis-of-micafungin-treatment-of-pulmonary-invasive-fungal-infection-in-pediatric-patients-with-acute-leukemia-or-post-hematopoietic-stem-cells-transplantation
#1
K Huang, K Y Qiu, L L Deng, J P Fang, Y Li, H X Guo, D H Zhou
Objective: To investigate the efficacy and safety of micafungin (MCF) for pulmonary invasive fungal disease (PIFD) in pediatric patients with acute leukemia or post hematopoietic stem cells transplantation. Method: Twenty-five neutropenic PIFD children with acute leukemia or post hematopoietic stem cells transplantation in Sun Yat-sen Memorial Hospital of Sun Yat-sen University were selected from January 2012 to June 2015, including 12 males and 13 females, age range 2-15 (average 6.2±2.0) years. There were 12 cases of acute leukemia (AL) after chemotherapy, 4 cases of acute leukemia (AL) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) and 9 cases of β-thalassemia major after allo-HSCT...
November 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/29140887/inconsistencies-between-two-cross-cultural-adaptations-of-the-hospital-survey-on-patient-safety-culture-into-french
#2
Bastien Boussat, Patrice François, Gérald Gandon, Joris Giai, Arnaud Seigneurin, Thomas Perneger, José Labarère
OBJECTIVES: Two cross-cultural adaptations of the 12-dimension Hospital Survey on Patient Safety Culture (HSOPSC) into French coexist: the Occelli and Vlayen versions. The objective of this study was to assess the psychometric properties of the Occelli version in comparison with those reported for the Vlayen and the original US versions of this instrument. METHODS: Using the original data from a cross-sectional study of 5,064 employees at a single university hospital in France, we examined the acceptability, internal consistency, factorial structure, and construct validity of the Occelli version of the HSOPSC...
November 15, 2017: Journal of Patient Safety
https://www.readbyqxmd.com/read/29140839/effectiveness-and-safety-of-a-thermosensitive-hydrogel-cultured-epidermal-allograft-for-burns
#3
Jaechul Yoon, Hyeong-Tae Yang, Haejun Yim, Yong-Suk Cho, Dohern Kym, Jun Hur, Wook Chun, Jong-Wook Lee, Chunjae Yoon
OBJECTIVE: To retest the safety and effectiveness of a thermosensitive hydrogel-type cultured epithelial allograft (KeraHeal-Allo; MCTT, Seoul, South Korea) and identify the subjective experience of patients and doctors with this product. DESIGN AND SETTING: Prospective interventional phase 3 study in 3 burn centers near Seoul, South Korea. PATIENTS: Thirty-three patients with deep second-degree burns larger than 200 cm (for intervention and control sites of 100 cm each) were enrolled...
December 2017: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29140497/integrating-complementary-and-traditional-practices-in-middle-eastern-supportive-cancer-care
#4
Eran Ben-Arye, Noah Samuels, Michel Daher, Ibrahim Turker, Omar Nimri, Maryam Rassouli, Michael Silbermann
The Middle East is a promising arena in which researchers can explore the interchange between cross-cultural traditional medicine and supportive cancer care, as provided within an integrative oncology setting. Integrative oncology research and clinical practice in this part of the world have been focusing, for the most part, on the use of herbal medicine and mind-body-spiritual modalities, both of which are deeply rooted in traditional medical care. A regional, multinational, and interdisciplinary collaboration is currently being undertaken as part of the academic activities of the Middle-East Research Group in Integrative Oncology (MERGIO)...
November 1, 2017: Journal of the National Cancer Institute. Monographs
https://www.readbyqxmd.com/read/29140453/faecal-transplantation-for-ibd-management-pitfalls-and-promises
#5
M N Quraishi, T Critchlow, N Bhala, N Sharma, T Iqbal
Background: Faecal microbiota transplantation (FMT) as a potential treatment for inflammatory bowel disease (IBD) is an area of active current research, having been stimulated by the remarkable efficacy of FMT in treatment of Clostridium difficile-associated colitis. Sources of data: This review is based on data from numerous case series on FMT in IBD since 1989 and results of four RCTs in ulcerative colitis (UC); three fully published. Areas of agreement: Early signals of short to medium-term efficacy of FMT for UC are promising...
November 13, 2017: British Medical Bulletin
https://www.readbyqxmd.com/read/29138540/a-qualitative-study-exploring-issues-related-to-medication-management-in-residential-aged-care-facilities
#6
Mariani Ahmad Nizaruddin, Marhanis-Salihah Omar, Adliah Mhd-Ali, Mohd Makmor-Bakry
Background: Globally, the population of older people is on the rise. As families are burdened with the high cost of care for aging members, demand is increasing for medical care and nursing homes. Thus, medication management is crucial to ensure that residents in a care center benefit and assist the management of the care center in reducing the burden of health care. This study is aimed to qualitatively explore issues related to medication management in residential aged care facilities (RACFs)...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/29137854/-inclusion-of-patient-safety-into-the-medical-degree-electives-description-of-the-experience-and-student-perception
#7
R Ladenheim, D Macchiavello, M Milberg
INTRODUCTION: One of the factors identified to reduce medical errors has been the organisational culture. Education is proposed as a tool for its modification, but this does not have a unique way of being achieved. This paper sought to describe a patient safety elective for medical students and to determine their perceptions on the subject. MATERIALS AND METHODS: A descriptive study was performed in the Center of Medical Education and Clinical Investigations, in Argentina...
November 11, 2017: Revista de Calidad Asistencial: Organo de la Sociedad Española de Calidad Asistencial
https://www.readbyqxmd.com/read/29134722/school-climate-and-college-attendance-for-black-adolescents-moving-beyond-college-going-culture
#8
Kelly A Minor, Aprile D Benner
Understanding how contexts promote positive educational outcomes is a critical objective of adolescent research. This study provides support for the established link between school climate and educational outcomes and expands our understanding of this association by examining multiple aspects of school climate in a sample of Black adolescents in the United States (N = 1,740). Data were drawn from the Education Longitudinal Study of 2002, and multinomial logistic regression and multiple group modeling in a structural equation modeling framework revealed that Black high school students' perceptions of school safety, school liking, and academic press were associated with enrollment in higher education...
November 14, 2017: Journal of Research on Adolescence: the Official Journal of the Society for Research on Adolescence
https://www.readbyqxmd.com/read/29131334/antioxidant-activities-of-lactic-acid-bacteria-for-quality-improvement-of-fermented-sausage
#9
Yulong Zhang, Ping Hu, Lijiao Lou, Jianlong Zhan, Min Fan, Dan Li, Qianwei Liao
Lactobacillus curvatus (SR6) and Lactobacillus paracasei (SR10-1) were assessed for their antioxidant activities and inoculated into sausages to investigate their effects on quality during fermentation. The results showed that L. curvatus SR6 had better DPPH• scavenging activity (59.67% ± 6.68%) and reducing power (47.31% ± 4.62%) and L. paracasei SR10-1 had better OH• scavenging activity (285.67% ± 2.00%) and anti-lipid peroxidation capacity (63.89% ± 0.93%). The superoxide dismutase activity of the cell culture fluid was greater than 47...
November 13, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/29130778/lack-of-induced-mutagenesis-in-e-coli-or-human-lymphoblast-cell-line-upon-long-term-sub-culturing-in-medium-from-irradiated-meat
#10
Sachin N Hajare, Jyoti Tripathi, Satyendra Gautam
PURPOSE: Current study was aimed to enhance the confidence of consumers as well as entrepreneurs towards food irradiation program. MATERIALS AND METHODS: In this work, safety of high dose (25 kGy) irradiated meat samples (HDIMS) was ascertained by scoring mutation frequency through a long-term sub-culturing study in Escherichia coli MG1655 cells (ATCC 700926) up to 1500 generations (at 1%), 250 generations (at 5 and 10%) and human lymphoblast thymidine kinase heterozygote (TK6) cell line (ATCC CRL-8015) [at two gene loci, tk(-/+) (thymidine kinase) and hprt(+) (Hypoxanthine Phosphoribosyltransferase)] up to 156 generations using goat meat sample...
November 13, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/29130123/informal-value-chain-actors-knowledge-and-perceptions-about-zoonotic-diseases-and-biosecurity-in-kenya-and-the-importance-for-food-safety-and-public-health
#11
Simon Nyokabi, Regina Birner, Bernard Bett, Linda Isuyi, Delia Grace, Denise Güttler, Johanna Lindahl
Zoonotic diseases, transmitted from animals to humans, are a public health challenge in developing countries. Livestock value chain actors have an important role to play as the first line of defence in safeguarding public health. However, although the livelihood and economic impacts of zoonoses are widely known, adoption of biosecurity measures aimed at preventing zoonoses is low, particularly among actors in informal livestock value chains in low and middle-income countries. The main objective of this study was to investigate knowledge of zoonoses and adoption of biosecurity measures by livestock and milk value chain actors in Bura, Tana River County, in Kenya, where cattle, camels, sheep and goats are the main livestock kept...
November 13, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/29127231/evaluation-of-psychometric-properties-of-the-german-hospital-survey-on-patient-safety-culture-and-its-potential-for-cross-cultural-comparisons-a-cross-sectional-study
#12
Nikoloz Gambashidze, Antje Hammer, Mareen Brösterhaus, Tanja Manser
OBJECTIVE: To study the psychometric characteristics of German version of the Hospital Survey on Patient Safety Culture and to compare its dimensionality to other language versions in order to understand the instrument's potential for cross-national studies. DESIGN: Cross-sectional multicentre study to establish psychometric properties of German version of the survey instrument. SETTING: 73 units from 37 departments of two German university hospitals...
November 9, 2017: BMJ Open
https://www.readbyqxmd.com/read/29126706/-clinical-governance-and-patient-safety-culture-in-clinical-laboratories-in-the-spanish-national-health-system
#13
Á Giménez-Marín, F Rivas-Ruiz
AIM: To conduct a situational analysis of patient safety culture in public laboratories in the Spanish National Health System and to determine the clinical governance variables that most strongly influence patient safety. METHOD: A descriptive cross-sectional study was carried out, in which a Survey of Patient Safety in Clinical Laboratories was addressed to workers in 26 participating laboratories. In this survey, which consisted of 45 items grouped into 6 areas, scores were assigned on a scale from 0 to 100 (where 0 is the lowest perception of patient safety)...
November 7, 2017: Revista de Calidad Asistencial: Organo de la Sociedad Española de Calidad Asistencial
https://www.readbyqxmd.com/read/29121500/validation-of-a-salmonella-loop-mediated-isothermal-amplification-assay-in-animal-food
#14
Kelly J Domesle, Qianru Yang, Thomas S Hammack, Beilei Ge
Loop-mediated isothermal amplification (LAMP) has emerged as a promising alternative to PCR for pathogen detection in food testing and clinical diagnostics. This study aimed to validate a Salmonella LAMP method run on both turbidimetry (LAMP I) and fluorescence (LAMP II) platforms in representative animal food commodities. The U.S. Food and Drug Administration (FDA)'s culture-based Bacteriological Analytical Manual (BAM) method was used as the reference method and a real-time quantitative PCR (qPCR) assay was also performed...
October 18, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29120515/the-effects-of-crew-resource-management-on-teamwork-and-safety-climate-at-veterans-health-administration-facilities
#15
Miriam E Schwartz, Deborah E Welsh, Douglas E Paull, Regina S Knowles, Lori D DeLeeuw, Robin R Hemphill, Keith E Essen, Gary L Sculli
Communication failure is a significant source of adverse events in health care and a leading root cause of sentinel events reported to the Joint Commission. The Veterans Health Administration National Center for Patient Safety established Clinical Team Training (CTT) as a comprehensive program to enhance patient safety and to improve communication and teamwork among health care professionals. CTT is based on techniques used in aviation's Crew Resource Management (CRM) training. The aviation industry has reached a significant safety record in large part related to the culture change generated by CRM and sustained by its recurrent implementation...
November 9, 2017: Journal of Healthcare Risk Management: the Journal of the American Society for Healthcare Risk Management
https://www.readbyqxmd.com/read/29120320/adapting-maternal-health-practice-to-co-morbidities-and-social-inequality-a-systematic-approach
#16
Aditi Iyer, V Srinidhi, Anuradha Sreevathsa, Gita Sen
The process of adapting universal guidelines to local institutional and cultural settings is recognized as important to their implementation and uptake. However, clarity on what, why and how to adapt in an evidence-based manner is still somewhat elusive. Health providers in low and middle income country contexts often have to deal with widely present co-morbidities and social inequalities among pregnant women. Since neither of these problems finds adequate discussion within the usual guidelines, and given the continual pressures posed by resource scarcity, health providers respond through ad hoc adaptations inimical to maternal safety and equity...
November 9, 2017: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
https://www.readbyqxmd.com/read/29119377/meat-retail-conditions-within-the-establishments-of-kigali-city-rwanda-bacteriological-quality-and-risk-factors-for-salmonella-occurrence
#17
Eugène Niyonzima, Martin Patrick Ongol, Yves Brostaux, Nicolas Korsak, Georges Daube, Anastase Kimonyo, Marianne Sindic
Meat constitutes one of the major vehicles for human foodborne infections. This study aimed to assess the retail conditions and to determine the microbiological quality and safety of meat retailed within the establishments of Kigali (Rwanda). A questionnaire survey was carried out in 150 retail outlets to characterise meat retail conditions. Additionally, 270 retail meat samples were analysed for the enumeration of hygiene indicator bacteria (total mesophilic bacteria and Escherichia coli) and for the qualitative detection of Salmonella, using conventional culture methods...
November 8, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/29118058/induced-pluripotent-stem-cell-ipsc-derived-extracellular-vesicles-are-safer-and-more-effective-for-cardiac-repair-than-ipscs
#18
Marta Adamiak, Guangming Cheng, Sylwia Bobis-Wozowicz, Lin Zhao, Sylwia Kedracka-Krok, Anweshan Samanta, Elzbieta Karnas, Yu-Ting Xuan, Bozena Skupien-Rabian, Xing Chen, Urszula Jankowska, Magdy Girgis, Malgorzata Sekula, Arash Davani, Slawomir Lasota, Robert J Vincent, Michal Sarna, Kathy L Newell, Ou-Li Wang, Nathaniel Dudley, Zbigniew Madeja, Buddhadeb Dawn, Ewa K Zuba-Surma
Rationale: Extracellular vesicles (EVs) are tiny membrane-enclosed droplets released by cells through membrane budding or exocytosis. The myocardial reparative abilities of EVs derived from induced pluripotent stem cells (iPSCs) have not been directly compared with the source iPSCs. Objective: To examine whether iPSC-derived EVs can influence the biological functions of cardiac cells in vitro; and compare the safety and efficacy of iPSC-EVs and iPSCs for cardiac repair in vivo. Methods and Results: Murine iPSCs were generated and EVs isolated from culture supernatants by sequential centrifugation...
November 8, 2017: Circulation Research
https://www.readbyqxmd.com/read/29117448/an-exploratory-study-of-safety-culture-biological-risk-management-and-hand-hygiene-of-healthcare-professionals
#19
Laurence Bernard, Alain Biron, Geneviève Lavigne, Julie Frechette, Agnès Bernard, Jonathan Mitchell, Mélanie Lavoie-Tremblay
AIMS: The objectives of the study were to: (1) examine the relationships between three different qualitative perceptions of safety culture and the Canadian Patient Safety Climate Survey factors; (2) determine whether these perceptions are associated with different hand hygiene practices. BACKGROUND: Healthcare-associated infections and safety cultures are a worldwide issue. During the A/H1N1 Influenza pandemic, Europe and North America did not have the same responses...
November 8, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/29116962/weaving-a-culture-of-safety-into-the-fabric-of-nursing
#20
Ilia M Echevarria, Michele Thoman
No abstract text is available yet for this article.
November 7, 2017: Nursing Management
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