keyword
https://read.qxmd.com/read/38489912/pik3r1-fusion-drives-chemoresistance-in-ovarian-cancer-by-activating-erk1-2-and-inducing-rod-and-ring-like-structures
#21
JOURNAL ARTICLE
Heidi Rausio, Alejandra Cervera, Vanina D Heuser, Gun West, Jaana Oikkonen, Elena Pianfetti, Marta Lovino, Elisa Ficarra, Pekka Taimen, Johanna Hynninen, Rainer Lehtonen, Sampsa Hautaniemi, Olli Carpén, Kaisa Huhtinen
Gene fusions are common in high-grade serous ovarian cancer (HGSC). Such genetic lesions may promote tumorigenesis, but the pathogenic mechanisms are currently poorly understood. Here, we investigated the role of a PIK3R1-CCDC178 fusion identified from a patient with advanced HGSC. We show that the fusion induces HGSC cell migration by regulating ERK1/2 and increases resistance to platinum treatment. Platinum resistance was associated with rod and ring-like cellular structure formation. These structures contained, in addition to the fusion protein, CIN85, a key regulator of PI3K-AKT-mTOR signaling...
March 14, 2024: Neoplasia: An International Journal for Oncology Research
https://read.qxmd.com/read/38489872/ovarian-cancer-ascites-confers-platinum-chemoresistance-to-ovarian-cancer-cells
#22
JOURNAL ARTICLE
Yifat Koren Carmi, Abed Agbarya, Hazem Khamaisi, Raymond Farah, Yelena Shechtman, Roman Korobochka, Jacob Gopas, Jamal Mahajna
Ovarian cancer (OC), the second most common form of gynecologic malignancy, has a poor prognosis and is often discovered in the late stages. Platinum-based chemotherapy is the first line of therapy. Nevertheless, treatment OC has proven challenging due to toxicity and the development of acquired resistance to therapy. Tumor microenvironment (TME) has been associated with platinum chemoresistance. Malignant ascites has been used as OC tumor microenvironment and its ability to induce platinum chemoresistance has been investigated...
March 14, 2024: Translational Oncology
https://read.qxmd.com/read/38489864/systematic-review-on-antibacterial-photodynamic-therapeutic-effects-of-transition-metals-ruthenium-and-iridium-complexes
#23
REVIEW
Anadil Gul, Munir Ahmad, Raza Ullah, Rizwan Ullah, Yan Kang, Wenchao Liao
The prevalence of antibiotic-resistant pathogenic bacteria poses a significant threat to public health and ranks among the principal causes of morbidity and mortality worldwide. Antimicrobial photodynamic therapy is an emerging therapeutic technique that has excellent potential to embark upon antibiotic resistance problems. The efficacy of this therapy hinges on the careful selection of suitable photosensitizers (PSs). Transition metal complexes, such as Ruthenium (Ru) and Iridium (Ir), are highly suitable for use as PSs because of their surface plasmonic resonance, crystal structure, optical characteristics, and photonics...
March 11, 2024: Journal of Inorganic Biochemistry
https://read.qxmd.com/read/38487245/-in-situ-sers-imaging-of-protein-specific-glycan-oxidation-on-living-cells-to-quantitatively-visualize-pathogen-cell-interactions
#24
JOURNAL ARTICLE
Yuru Wang, Shan Wu, Yuanjiao Yang, Yuhui Yang, Huipu Liu, Yunlong Chen, Huangxian Ju
Glycan oxidation on the cell surface occurs in many specific life processes including pathogen-cell interactions. This work develops a surface-enhanced Raman scattering (SERS) imaging strategy for in situ quantitative monitoring of protein-specific glycan oxidation mediated pathogen-cell interactions by utilizing Raman reporter DTNB and aptamer co-assembled platinum shelled gold nanoparticles (Au@Pt-DTNB/Apt). Using Fusarium graminearum ( FG ) and MCF-7 cells as models, Au@Pt-DTNB/Apt can specifically bind to MUC1 protein on the cell surface containing heavy galactose (Gal) and N -acetylgalactosamine (GalNAc) modification...
March 13, 2024: Chemical Science
https://read.qxmd.com/read/38487220/tuning-the-photoactivated-anticancer-activity-of-pt-iv-compounds-via-distant-ferrocene-conjugation
#25
JOURNAL ARTICLE
Huayun Shi, Fortuna Ponte, Jaspreet S Grewal, Guy J Clarkson, Cinzia Imberti, Ian Hands-Portman, Robert Dallmann, Emilia Sicilia, Peter J Sadler
Photoactive prodrugs offer potential for spatially-selective antitumour activity with minimal effects on normal tissues. Excited-state chemistry can induce novel effects on biochemical pathways and combat resistance to conventional drugs. Photoactive metal complexes in particular, have a rich and relatively unexplored photochemistry, especially an ability to undergo facile intersystem crossing and populate triplet states. We have conjugated the photoactive octahedral Pt(iv) complex trans , trans , trans -[Pt(N3 )2 (OH)2 (py)2 ] to ferrocene to introduce novel features into a candidate photochemotherapeutic drug...
March 13, 2024: Chemical Science
https://read.qxmd.com/read/38480884/evolutionary-trajectories-of-small-cell-lung-cancer-under-therapy
#26
JOURNAL ARTICLE
Julie George, Lukas Maas, Nima Abedpour, Maria Cartolano, Laura Kaiser, Rieke N Fischer, Andreas H Scheel, Jan-Philipp Weber, Martin Hellmich, Graziella Bosco, Caroline Volz, Christian Mueller, Ilona Dahmen, Felix John, Cleidson Padua Alves, Lisa Werr, Jens Peter Panse, Martin Kirschner, Walburga Engel-Riedel, Jessica Jürgens, Erich Stoelben, Michael Brockmann, Stefan Grau, Martin Sebastian, Jan A Stratmann, Jens Kern, Horst-Dieter Hummel, Balazs Hegedüs, Martin Schuler, Till Plönes, Clemens Aigner, Thomas Elter, Karin Toepelt, Yon-Dschun Ko, Sylke Kurz, Christian Grohé, Monika Serke, Katja Höpker, Lars Hagmeyer, Fabian Doerr, Khosro Hekmath, Judith Strapatsas, Karl-Otto Kambartel, Geothy Chakupurakal, Annette Busch, Franz-Georg Bauernfeind, Frank Griesinger, Anne Luers, Wiebke Dirks, Rainer Wiewrodt, Andrea Luecke, Ernst Rodermann, Andreas Diel, Volker Hagen, Kai Severin, Roland T Ullrich, Hans Christian Reinhardt, Alexander Quaas, Magdalena Bogus, Cornelius Courts, Peter Nürnberg, Kerstin Becker, Viktor Achter, Reinhard Büttner, Jürgen Wolf, Martin Peifer, Roman K Thomas
The evolutionary processes that underlie the marked sensitivity of small cell lung cancer (SCLC) to chemotherapy and rapid relapse are unknown1-3 . Here we determined tumour phylogenies at diagnosis and throughout chemotherapy and immunotherapy by multiregion sequencing of 160 tumours from 65 patients. Treatment-naive SCLC exhibited clonal homogeneity at distinct tumour sites, whereas first-line platinum-based chemotherapy led to a burst in genomic intratumour heterogeneity and spatial clonal diversity...
March 13, 2024: Nature
https://read.qxmd.com/read/38479871/treatment-outcomes-of-second-line-systemic-therapy-for-neuroendocrine-prostate-cancer-a-report-of-four-cases
#27
JOURNAL ARTICLE
Yuto Tsubonuma, Keita Funakoshi, Tomohisa Takaba, Kazumasa Jyojima, Akinori Minato, Ikko Tomisaki, Kenichi Harada, Naohiro Fujimoto
Neuroendocrine prostate cancer (NEPC) is a histological variant of prostate cancer and is characterized by aggressiveness and poor clinical outcomes. NEPC usually develops as a mechanism of treatment resistance in patients receiving hormone therapy for advanced prostate cancer. NEPC is sensitive to primary platinum-based chemotherapy, and has a short response duration. Second-line therapy is required in many cases, but clinical data on subsequent treatment after progression to first-line chemotherapy is limited...
2024: Journal of UOEH
https://read.qxmd.com/read/38479209/chemotherapy-response-score-as-a-predictor-of-survival-in-ovarian-cancer-patients
#28
JOURNAL ARTICLE
Ioannis Rodolakis, Michalis Liontos, Vasilios Pergialiotis, Dimitrios Haidopoulos, Maria Kaparelou, Dimitrios Efthimios Vlachos, Meletios Athanasios Dimopoulos, Dimitrios Loutradis, Alexandros Rodolakis, Aristotelis Bamias, Nikolaos Thomakos
OBJECTIVE: The chemotherapy response score (CRS) has been widely adopted as a predictive tool for ovarian cancer survival. In the present study, we seek to define differences in survival rates among patients grouped in the traditionally established three-tiered system and those who have not been offered debulking surgery. STUDY DESIGN: We designed a retrospective cohort study involving women treated with chemotherapy and offered interval or late debulking surgery for ovarian cancer...
March 7, 2024: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://read.qxmd.com/read/38478398/primary-resistance-to-ret-inhibition-in-a-ret-fusion-positive-pancreatic-neuroendocrine-carcinoma
#29
JOURNAL ARTICLE
Blake J McKinley, Tucker W Coston, Jason S Starr
We present a 54-year-old White male with a diagnosis of stage IV pancreatic neuroendocrine carcinoma. Next-generation sequencing of the tumor/blood identified a complex tumor genome, which included a rearranged during transfection (RET) gene fusion. The patient initially received cytotoxic chemotherapy with a significant radiographic response. After 4 cycles of chemotherapy, the patient was transitioned to a clinical trial using selpercatinib, a RET inhibitor, as maintenance therapy. Unfortunately, our patient developed progression of disease at the first treatment monitoring scan...
March 13, 2024: Oncologist
https://read.qxmd.com/read/38474631/platinum-0-%C3%AE-2-1-2-e-ditosylethene-complexes-bearing-phosphine-isocyanide-and-n-heterocyclic-carbene-ligands-synthesis-and-cytotoxicity-towards-ovarian-and-breast-cancer-cells
#30
JOURNAL ARTICLE
Nicola Compagno, Rachele Piccolo, Enrica Bortolamiol, Nicola Demitri, Flavio Rizzolio, Fabiano Visentin, Thomas Scattolin
A wide range of platinum(0)-η2 -( E )-1,2-ditosylethene complexes bearing isocyanide, phosphine and N -heterocyclic carbene ancillary ligands have been prepared with high yields and selectivity. All the novel products underwent thorough characterization using spectroscopic techniques, including NMR and FT-IR analyses. Additionally, for some compounds, the solid-state structures were elucidated through X-ray diffractometry. The synthesized complexes were successively evaluated for their potential as anticancer agents against two ovarian cancer cell lines (A2780 and A2780 cis ) and one breast cancer cell line (MDA-MB-231)...
March 1, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38474580/recently-reported-biological-activities-and-action-targets-of-pt-ii-and-cu-ii-based-complexes
#31
REVIEW
Cristhian Eduardo Maciel-Flores, Juan Antonio Lozano-Alvarez, Egla Yareth Bivián-Castro
Most diseases that affect human beings across the world are now treated with drugs of organic origin. However, some of these are associated with side effects, toxicity, and resistance phenomena. For the treatment of many illnesses, the development of new molecules with pharmacological potential is now an urgent matter. The biological activities of metal complexes have been reported to have antitumor, antimicrobial, anti-inflammatory, anti-infective and antiparasitic effects, amongst others. Metal complexes are effective because they possess unique properties...
February 29, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38474294/different-patterns-of-platinum-resistance-in-ovarian-cancer-cells-with-homologous-recombination-proficient-and-deficient-background
#32
JOURNAL ARTICLE
Michela Chiappa, Federica Guffanti, Chiara Grasselli, Nicolò Panini, Alessandro Corbelli, Fabio Fiordaliso, Giovanna Damia
Platinum compounds are very active in first-line treatments of ovarian carcinoma. In fact, high rates of complete remission are achieved, but most patients eventually relapse with resistant disease. Many mechanisms underlying the platinum-resistant phenotype have been reported. However, there are no data in the same isogenic cell system proficient and deficient in homologous recombination (HR) on platinum-acquired resistance that might unequivocally clarify the most important mechanism associated with resistance...
March 6, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38472557/a-signature-of-circulating-mirnas-predicts-the-prognosis-and-therapeutic-outcome-of-taxane-platinum-regimen-in-advanced-ovarian-carcinoma-patients
#33
JOURNAL ARTICLE
Ranita Pal, Trisha Choudhury, Madhurima Ghosh, Manisha Vernakar, Partha Nath, Vilas Deorao Nasare
PURPOSE: Ovarian carcinoma (OC) is ranked as the eighth most lethal gynecological cancer due to late diagnosis and high recurrence. Existing biomarkers are lacking to predict the recurrence and stratify patients who are likely to benefit from chemotherapy. MicroRNAs (miRNAs/miRs) are persistently present in humans and are capable of predicting treatment outcomes. Thus, the purpose of the study was to assess the potential of circulatory miRNAs to predict the efficacy of OC. METHODS: Newly diagnosed n = 208 OC patients were administrated neoadjuvant/adjuvant chemotherapy (taxane + platinum) after surgery...
March 12, 2024: Clinical & Translational Oncology
https://read.qxmd.com/read/38469896/platinum-nanoparticles-regulated-v-2-c-mxene-nanoplatforms-with-nir-ii-enhanced-nanozyme-effect-for-photothermal-and-chemodynamic-anti-infective-therapy
#34
JOURNAL ARTICLE
Xiaojun He, Ya Lv, Yanling Lin, Hong Yu, Yipiao Zhang, Yuhua Tong, Chunwu Zhang
Given the challenge of multidrug resistance in antibiotics, non-antibiotic-dependent antibacterial strategies show promise for anti-infective therapy. V2 C MXene-based nanomaterials have demonstrated strong biocompatibility and photothermal conversion efficiency (PCE) for photothermal therapy (PTT). However, the limitation of V2 C MXene's laser irradiation to the near-infrared region I (NIR-I) restricts tissue penetration, making it difficult to achieve complete bacterial eradication with single-effect therapeutic strategies...
March 12, 2024: Advanced Materials
https://read.qxmd.com/read/38468115/standardized-bench-test-evaluation-of-biomechanical-characteristics-of-stents-used-in-right-ventricular-outflow-tract-revalvulation
#35
JOURNAL ARTICLE
Pierre-Guillaume Piriou, Julien Plessis, Thibaut Manigold, Vincent Letocart, Robin Le Ruz, Paul Padovani, Patrice Guérin
PURPOSE: Pre-stenting of the right ventricular outflow tract (RVOT) is commonly performed before percutaneous pulmonary valve implantation (PPVI), to relieve obstruction, prevent valved stent fractures, and provide a landing zone. This study aimed to evaluate the biomechanical characteristics of the stents currently used to perform pre-stenting of the RVOT. METHODS: We assessed five commercially available stents: Cheatham-Platinum Stent ("CP Stent"), AndraStent XL, AndraStent XXL, Optimus XL, and Optimus XXL...
March 11, 2024: Cardiovascular Engineering and Technology
https://read.qxmd.com/read/38463803/long-non-coding-rnas-in-drug-resistance-across-the-top-five-cancers-update-on-their-roles-and-mechanisms
#36
REVIEW
Yue Shi, Joseph Adu-Amankwaah, Qizhong Zhao, Xin Li, Qianxue Yu, Aisha Bushi, Jinxiang Yuan, Rubin Tan
Cancer drug resistance stands as a formidable obstacle in the relentless fight against the top five prevalent cancers: breast, lung, colorectal, prostate, and gastric cancers. These malignancies collectively account for a significant portion of cancer-related deaths worldwide. In recent years, long non-coding RNAs (lncRNAs) have emerged as pivotal players in the intricate landscape of cancer biology, and their roles in driving drug resistance are steadily coming to light. This comprehensive review seeks to underscore the paramount significance of lncRNAs in orchestrating resistance across a spectrum of different cancer drugs, including platinum drugs (DDP), tamoxifen, trastuzumab, 5-fluorouracil (5-FU), paclitaxel (PTX), and Androgen Deprivation Therapy (ADT) across the most prevalent types of cancer...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38461903/unraveling-the-immune-landscape-and-therapeutic-biomarker-pmepa1-for-oxaliplatin-resistance-in-colorectal-cancer-a-comprehensive-approach
#37
JOURNAL ARTICLE
Zhengguang Zhang, Tianming Lu, Zhe Zhang, Zixian Liu, Ruoning Qian, Ruogu Qi, Fuqiong Zhou, Min Li
Oxaliplatin (OXA) is a platinum-based chemotherapeutic agent with promising applications in the treatment of various malignancies, particularly colorectal cancer (CRC). However, the management of OXA resistance remains an ongoing obstacle in CRC therapy. This study aims to comprehensively investigate the immune landscape, targeted therapeutic biomarkers, and mechanisms that influence OXA resistance in CRC. Our results demonstrated that our OXA resistance-based CRC prognostic model not only provides risk assessment for patients but also reflects the immune landscape of patients...
March 8, 2024: Biochemical Pharmacology
https://read.qxmd.com/read/38461087/-targeting-the-spliceosome-a-new-therapeutic-strategy-to-counteract-chemotherapy-resistance-in-lung-cancer
#38
JOURNAL ARTICLE
A Shreim, S Gazzeri, B Eymin
Lung cancer is the first cancer-related cause of death worldwide. This is in partially due to therapeutic resistance, which occurs in around 70% of patients, especially those receiving platinum salts, the gold-standard chemotherapy. The massive deregulation of alternative transcript splicing processes observed in many cancers has led to the development of a new class of pharmacological agents aimed at inhibiting the activity of the splicing machinery (spliceosome). The molecular mechanisms by which these inhibitors act remain largely unknown, as do the benefits of using them in combination with other therapies...
March 8, 2024: Revue des Maladies Respiratoires
https://read.qxmd.com/read/38460481/novel-titanocene-y-derivative-with-albumin-affinity-exhibits-improved-anticancer-activity-against-platinum-resistant-cells
#39
JOURNAL ARTICLE
Sergio Gomez-Lopez, Rosario Serrano, Boiko Cohen, Isabel Martinez-Argudo, Laura Lopez-Sanz, Marta Carmen Guadamillas, Raul Calero, Maria Jose Ruiz
The antitumor activity of Ti(IV)-based compounds put them in the spotlight for cancer treatment in the past, but their lack of stability in vivo due to a high rate of hydrolysis has hindered their development as antitumor drugs. As a possible solution for this problem, we have reported a synthesis strategy through which we combined a titanocene fragment, a tridentate ligand, and a long aliphatic chain. This strategy allowed us to generate a titanium compound (Myr-Ti) capable of interacting with albumin, highly stable in water and with cytotoxic activity in tumor cells[1]...
March 6, 2024: Journal of Inorganic Biochemistry
https://read.qxmd.com/read/38460387/platinum-group-nanoparticles-doped-bcn-matrix-efficient-catalysts-for-the-electrocatalytic-reduction-of-nitrate-to-ammonia
#40
JOURNAL ARTICLE
Zhengxi Wang, Shiying Xia, Xuefan Deng, Glib Baryshnikov, Artem Kuklin, Hans Ågren, Haibo Zhang
The effective treatment of nitrate (NO3 - ) in water as a nitrogen source and electrocatalytic NO3 - reduction to ammonia (NH3 ) (NRA) have become preferred methods for NO3 - -to-NH3 conversion. Achieving efficient NO3 - -to-NH3 conversion requires the design and development of electrode materials with high activity and efficiency for the electrocatalytic NRA reaction. Herein, based on the special properties of dodecahydro-closo-dodecaborate anions, a BCN matrix, loaded with platinum-group nanoparticles (namely, Pd/BCN, Pt/BCN, and Ru/BCN), was prepared using a simple method for the electrocatalytic NRA reaction...
March 6, 2024: Journal of Colloid and Interface Science
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