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https://www.readbyqxmd.com/read/29241119/bench-to-bedside-review-possible-role-of-vitamin-d-in-autism-spectrum-disorder
#1
REVIEW
Feiyong Jia, Ling Shan, Bing Wang, Honghua Li, Chunyue Miao, Zhida Xu, Ching-Po Lin, Khaled Saad
Autism spectrum disorder (ASD) is a group of dysfunctions in social interaction, communication, and behaviors. Studies have demonstrated that vitamin D deficiency during pregnancy and in individuals increased the risk of ASD. A genetic polymorphism study has pinpointed that genotype AA/A-allele of GC rs4588 in children is associated with ASD, which encodes the vitamin D binding protein. Translating the mentioned points into clinical practice, several clinical trials have demonstrated that vitamin D supplementation can improve the core symptoms in children with ASD...
December 6, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29237275/an-exploratory-longitudinal-study-of-social-and-language-outcomes-in-children-with-autism-in-bilingual-home-environments
#2
Vanessa Zhou, Jeffrey A Munson, Jessica Greenson, Yan Hou, Sally Rogers, Annette M Estes
Little is known about outcomes of early intervention for children with autism spectrum disorder reared in bilingual homes. There are concerns that social communication deficits among children with autism spectrum disorder may reduce the developmental benefits of early intervention for children with autism spectrum disorder raised in bilingual environments. We conducted an exploratory analysis of cross-sectional and longitudinal data from a larger study to explore associations between home language environment and language ability and social skills in response to early autism spectrum disorder intervention...
December 1, 2017: Autism: the International Journal of Research and Practice
https://www.readbyqxmd.com/read/29234739/effects-of-cross-rearing-with-social-peers-on-myelination-in-the-medial-prefrontal-cortex-of-a-mouse-model-with-autism-spectrum-disorder
#3
Manabu Makinodan, Kazuki Okumura, Daisuke Ikawa, Yasunori Yamashita, Kazuhiko Yamamuro, Michihiro Toritsuka, Sohei Kimoto, Takahira Yamauchi, Takashi Komori, Yoshinori Kayashima, Hiroki Yoshino, Akio Wanaka, Toshifumi Kishimoto
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impaired social interaction, poor communication skills, and repetitive/restrictive behaviors. Recent studies have indicated that early rehabilitative intervention can alleviate the symptoms of individuals with ASD. However, it remains unknown whether rehabilitative intervention can restore brain structures such as myelin, which generally shows abnormalities in individuals with ASD. Therefore, in the present study, we used a mouse model of ASD (BTBR mice) that demonstrated asocial behaviors and hypomyelination in the medial prefrontal cortex (mPFC) to investigate whether interaction with social peers (C57BL/6J mice) has an effect on myelination...
November 2017: Heliyon
https://www.readbyqxmd.com/read/29225922/using-participatory-learning-action-pla-research-techniques-for-inter-stakeholder-dialogue-in-primary-healthcare-an-analysis-of-stakeholders-experiences
#4
T de Brún, M O'Reilly-de Brún, E Van Weel-Baumgarten, N Burns, C Dowrick, C Lionis, C O'Donnell, F S Mair, M Papadakaki, A Saridaki, W Spiegel, C Van Weel, M Van den Muijsenbergh, A MacFarlane
Plain English summary: It is important for health care workers to know the needs and expectations of their patients. Therefore, service users have to be involved in research. To achieve a meaningful dialogue between service users, healthcare workers and researchers, participatory methods are needed. This paper describes how the application of a specific participatory methodology, Participatory Learning and Action (PLA) can lead to such a meaningful dialogue. In PLA all stakeholders are regarded as equal partners and collaborators in research...
2017: Research Involvement and Engagement
https://www.readbyqxmd.com/read/29225339/early-speech-development-in-koolen-de-vries-syndrome-limited-by-oral-praxis-and-hypotonia
#5
Angela T Morgan, Leenke van Haaften, Karen van Hulst, Carol Edley, Cristina Mei, Tiong Yang Tan, David Amor, Simon E Fisher, David A Koolen
Communication disorder is common in Koolen de Vries syndrome (KdVS), yet its specific symptomatology has not been examined, limiting prognostic counselling and application of targeted therapies. Here we examine the communication phenotype associated with KdVS. Twenty-nine participants (12 males, 4 with KANSL1 variants, 25 with 17q21.31 microdeletion), aged 1.0-27.0 years were assessed for oral-motor, speech, language, literacy, and social functioning. Early history included hypotonia and feeding difficulties...
December 11, 2017: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/29223042/experiences-of-early-labour-management-from-perspectives-of-women-labour-companions-and-health-professionals-a-systematic-review-of-qualitative-evidence
#6
REVIEW
Sarah Beake Rm Ma Research Associate, Yan-Shing Chang Ba MPhil PhD Lecturer, Helen Cheyne Rm Rgn MSc PhD Professor Of Midwifery, Helen Spiby MPhil Rn Rm Professor Of Midwifery, Jane Sandall Rm MSc PhD Professor Of Social Science And Women's Health, Debra Bick
OBJECTIVES: to examine evidence of women's, labour companions' and health professionals' experiences of management of early labour to consider how this could be enhanced to better reflect women's needs. DESIGN: a systematic review of qualitative evidence. SETTING AND PARTICIPANTS: women in early labour with term, low risk singleton pregnancies, not booked for a planned caesarean birth or post-dates induction of labour, their labour companions, and health professionals responsible for early labour care (e...
November 13, 2017: Midwifery
https://www.readbyqxmd.com/read/29219245/behavior-profiles-of-children-with-autism-spectrum-disorder-in-kindergarten-comparison-with-other-developmental-disabilities-and-typically-developing-children
#7
Magdalena Janus, Emma Mauti, Matt Horner, Eric Duku, Ayesha Siddiqua, Scott Davies
Monitoring behavior patterns that may be specific to autism spectrum disorder (ASD) at a population level has the potential to improve the allocation of intervention strategies and reduction of the burden of the disease. In Ontario, Canada, developmental data are regularly collected for all kindergarten children with the Early Development Instrument (EDI), a teacher-completed questionnaire that provides information on children's status in five domains: physical, social, emotional, language/cognitive, and communication/general knowledge...
December 8, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/29218791/a-novel-approach-to-training-attention-and-gaze-in-asd-a-feasibility-and-efficacy-pilot-study
#8
Leanne Chukoskie, Marissa Westerfield, Jeanne Townsend
In addition to the social, communicative and behavioral symptoms that define the disorder, individuals with ASD have difficulty re-orienting attention quickly and accurately. Similarly, fast re-orienting saccadic eye movements are also inaccurate and more variable in both endpoint and timing. Atypical gaze and attention are among the earliest symptoms observed in ASD. Disruption of these foundation skills critically affects development of higher level cognitive and social behavior. We propose that interventions aimed at these early deficits that support social and cognitive skills will be broadly effective...
December 8, 2017: Developmental Neurobiology
https://www.readbyqxmd.com/read/29215309/can-teacher-child-relationships-support-human-rights-to-freedom-of-opinion-and-expression-education-and-participation
#9
Cen Wang, Linda J Harrison, Sharynne McLeod, Sue Walker, Jantine L Spilt
PURPOSE: This study explored how teacher-child relationships change over the early school years, in terms of closeness and conflict, whether these trajectories differ in type and frequency for children with typical development and children with speech and language concern (SLC), and whether the trajectories are associated with school outcomes at 12-13 years. METHOD: Participants were children, parents and teachers in the Longitudinal Study of Australian Children...
December 7, 2017: International Journal of Speech-language Pathology
https://www.readbyqxmd.com/read/29211740/a-systematic-review-and-meta-analysis-of-comprehensive-interventions-for-pre-school-children-with-autism-spectrum-disorder-asd
#10
Yoshiyuki Tachibana, Celine Miyazaki, Erika Ota, Rintaro Mori, Yeonhee Hwang, Eriko Kobayashi, Akiko Terasaka, Julian Tang, Yoko Kamio
BACKGROUND: There has an increasing number of published trials on psychosocial intervention programmes for pre-school children with autism spectrum disorder (ASD). To achieve better quality of unbiased evidence for the effectiveness of ASD interventions, it is necessary to conduct a comprehensive review that covers studies with adequate quality standards, such as randomised controlled trials (RCTs), and different types of intervention In this study, we categorize interventions for ASD as behavioural, social-communication focused, and multimodal developmental based on Howlin's classification of early interventions for children with ASD...
2017: PloS One
https://www.readbyqxmd.com/read/29209697/false-belief-development-in-children-who-are-hard-of-hearing-compared-with-peers-with-normal-hearing
#11
Elizabeth A Walker, Sophie E Ambrose, Jacob Oleson, Mary Pat Moeller
Purpose: This study investigates false belief (FB) understanding in children who are hard of hearing (CHH) compared with children with normal hearing (CNH) at ages 5 and 6 years and at 2nd grade. Research with this population has theoretical significance, given that the early auditory-linguistic experiences of CHH are less restricted compared with children who are deaf but not as complete as those of CNH. Method: Participants included CHH and CNH who had completed FB tasks as part of a larger multicenter, longitudinal study on outcomes of children with mild-to-severe hearing loss...
December 6, 2017: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/29204259/early-development-of-infants-with-neurofibromatosis-type-1-a-case-series
#12
Anna May Kolesnik, Emily Jane Harrison Jones, Shruti Garg, Jonathan Green, Tony Charman, Mark Henry Johnson
Background: Prospective studies of infants at familial risk for autism spectrum disorder (ASD) have yielded insights into the earliest signs of the disorder but represent heterogeneous samples of unclear aetiology. Complementing this approach by studying cohorts of infants with monogenic syndromes associated with high rates of ASD offers the opportunity to elucidate the factors that lead to ASD. Methods: We present the first report from a prospective study of ten 10-month-old infants with neurofibromatosis type 1 (NF1), a monogenic disorder with high prevalence of ASD or ASD symptomatology...
2017: Molecular Autism
https://www.readbyqxmd.com/read/29198284/facilitating-autism-research
#13
Deborah Fein, Molly Helt
Early autism research focused on behavior and cognition. In recent decades, the pace of research has accelerated, and advances in imaging and genetics have allowed the accumulation of biological data. Nevertheless, a coherent picture of the syndrome at either phenotypic or biological level has not emerged. We see two fundamental obstacles to progress in basic understanding of autism. First, the two defining features (impairment in social interactions and communication, and restricted, repetitive behaviors and interests) are historically seen as integrally related...
October 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/29193826/validation-of-eye-tracking-measures-of-social-attention-as-a-potential-biomarker-for-autism-clinical-trials
#14
Michael Murias, Samantha Major, Katherine Davlantis, Lauren Franz, Adrianne Harris, Benjamin Rardin, Maura Sabatos-DeVito, Geraldine Dawson
Social communication impairments are a core feature of autism spectrum disorder (ASD), and this class of symptoms is a target for treatments for the disorder. Measures of social attention, assessed via eye-gaze tracking (EGT), have been proposed as an early efficacy biomarker for clinical trials targeting social communication skills. EGT measures have been shown to differentiate children with ASD from typical children; however, there is less known about their relationships with social communication outcome measures that are typically used in ASD clinical trials...
November 29, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/29188589/psychometric-properties-of-spanish-adaptation-of-the-pdd-mrs-scale-in-adults-with-intellectual-developmental-disorders-the-evtea-di-scale
#15
Maria José Cortés, Carmen Orejuela, Gemma Castellví, Annabel Folch, Lluís Rovira, Luis Salvador-Carulla, Marcia Irazábal, Silvia Muñoz, Josep Maria Haro, Elisabet Vilella, Rafael Martínez-Leal
Strategies for the early detection of autism spectrum disorders (ASD) in people with intellectual developmental disorder (IDD) are urgently needed, but few specific tools have been developed. The present study examines the psychometric properties of the EVTEA-DI, a Spanish adaptation of the PDD-MRS, in a large randomized sample of 979 adults with IDD. Factorial solution analysis suggested a three-factor solution (stereotyped behavior, communication, and social behavior). The EVTEA-DI showed good reliability and convergent validity when compared to the Childhood Autism Rating Scale...
November 29, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/29183980/speaker-gaze-increases-information-coupling-between-infant-and-adult-brains
#16
Victoria Leong, Elizabeth Byrne, Kaili Clackson, Stanimira Georgieva, Sarah Lam, Sam Wass
When infants and adults communicate, they exchange social signals of availability and communicative intention such as eye gaze. Previous research indicates that when communication is successful, close temporal dependencies arise between adult speakers' and listeners' neural activity. However, it is not known whether similar neural contingencies exist within adult-infant dyads. Here, we used dual-electroencephalography to assess whether direct gaze increases neural coupling between adults and infants during screen-based and live interactions...
November 28, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29182951/the-aetiology-of-borderline-personality-disorder-bpd-contemporary-theories-and-putative-mechanisms
#17
REVIEW
Catherine Winsper
This article presents an overview of current knowledge regarding the aetiology of Borderline Personality Disorder (BPD). It begins with a brief synopsis of early research and theory, and discusses how changing conceptualisations of BPD have impacted on our aetiological knowledge. Contemporary theories are described and presented within a developmental psychopathology framework. Deficient co-regulation and social communication in infancy are purported to underpin emotional dysregulation and social cognition deficits across development...
November 7, 2017: Current Opinion in Psychology
https://www.readbyqxmd.com/read/29181689/do-parents-and-clinicians-agree-on-ratings-of-autism-related-behaviors-at-12-months-of-age-a-study-of-infants-at-high-and-low-risk-for-asd
#18
Suzanne L Macari, Grace C Wu, Kelly K Powell, Scuddy Fontenelle, Deanna M Macris, Katarzyna Chawarska
Given the emphasis on early screening for ASD, it is crucial to examine the concordance between parent report and clinician observation of autism-related behaviors. Similar items were compared from the First Year Inventory (Baranek et al. First-Year Inventory (FYI) 2.0. University of North Carolina, Chapel Hill, 2003), a parent screener for ASD, and the ADOS-2 Toddler Module (Lord et al. 2013), a standardized ASD diagnostic tool. Measures were administered concurrently to 12-month-olds at high and low risk for ASD...
November 27, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/29178408/spousal-recollections-of-early-signs-of-primary-progressive-aphasia
#19
Margaret Pozzebon, Jacinta Douglas, David Ames
BACKGROUND: Although primary progressive aphasia (PPA) is characterized by progressive loss of language and communication skills, knowledge about the earliest emerging signs announcing the onset of this condition is limited. AIMS: To explore spousal recollections regarding the earliest signs of PPA and to compare the nature of the earliest perceived symptoms across the three PPA variants. METHODS & PROCEDURES: In-depth interviews focusing on the earliest signs of illness onset were conducted with 13 spouses whose partners were diagnosed with PPA...
November 26, 2017: International Journal of Language & Communication Disorders
https://www.readbyqxmd.com/read/29172197/-voxel-based-morphometry-and-social-cognitive-function-in-parkinson-s-disease
#20
Mutsutaka Kobayakawa
In recent years, voxel-based morphometry (VBM) has been increasingly used to investigate local brain structures in Parkinson's disease (PD). Compared to healthy participants, PD patients tend to show reduced brain volume in limbic and paralimbic areas in early disease stages, while the neocortical areas, such as the temporal and frontal cortices, are affected in advanced patients. Moreover, there are many studies showing correlation between cognitive performance and local brain volume. In the last decade, emotional and social cognitive function, such as facial emotion recognition, emotional decision-making, and theory of mind, have been the target of VBM analysis in PD...
November 2017: Brain and Nerve, Shinkei Kenkyū No Shinpo
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