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Lymphoma, leukemia, lymph node

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https://www.readbyqxmd.com/read/29903571/role-of-cxcl12-and-cxcr4-in-the-pathogenesis-of-hematological-malignancies
#1
Amnon Peled, Shiri Klein, Katia Beider, Jan A Burger, Michal Abraham
The chemokine receptor CXCR4 and its ligand stromal cell-derived factor-1 (SDF-1/CXCL12) are important players in the cross-talk among lymphoma, myeloma and leukemia cells and their microenvironments. In hematological malignancies and solid tumors, the overexpression of CXCR4 on the cell surface has been shown to be responsible for disease progression, increasing tumor cell survival and chemoresistance and metastasis to organs with high CXCL12 levels (e.g., lymph nodes and bone marrow (BM)). Furthermore, the overexpression of CXCR4 has been found to have prognostic significance for disease progression in many type of tumors including lymphoma, leukemia, glioma, and prostate, breast, colorectal, renal, and hepatocellular carcinomas...
September 2018: Cytokine
https://www.readbyqxmd.com/read/29898383/foxp3-positive-t-cell-lymphomas-in-non-htlv1-carriers-include-alk-negative-anaplastic-large-cell-lymphoma-expanding-the-spectrum-of-t-cell-lymphomas-with-regulatory-phenotype
#2
Cristiane R Ferreira, Shuchun Zhao, Malaya K Sahoo, Benjamin Pinsky, Jenna Weber, Luis A P C Lage, Juliana Pereira, Maria C N Zerbini, Yasodha Natkunam
Forkhead box P3 (FOXP3) is a specific marker for regulatory T-cells (Tregs). We report 6 cases of T-cell lymphomas with Treg phenotype based on diffuse positivity for FOXP3 in tumor cells. The patients showed a median age of 56years with a male predominance. Sites of disease included lymph nodes (4), skin (2), subcutaneous tissue (1) and bone marrow (1). All cases showed monomorphic large cells, some with Hodgkin-like or anaplastic cells. All cases expressed pan T cell markers and lacked cytotoxic markers; one case showed diffuse PD1 staining...
June 10, 2018: Human Pathology
https://www.readbyqxmd.com/read/29796007/b-chronic-lymphocytic-leukemia-showed-triple-transformation-to-diffuse-large-b-cell-cd20-negative-and-t-cell-neoplasm-during-ofatumumab-treatment-a-case-report
#3
Osamu Imataki, Makiko Uemura
Background: Chronic lymphocytic leukemia (CLL) is a mature lymphoid neoplasm currently categorized as an indolent type of malignant lymphoma. CLL progresses slowly over years, but it eventually transforms to a more aggressive lymphoma such as the diffuse large B-cell (DLBCL) type, also known as Richter's syndrome. Case presentation: We treated a 69-year-old Japanese male who was histologically diagnosed with Richter's syndrome after 6 years of CLL. His lymphadenopathy had systemically progressed for years, with lymphocyte counts of less than 10,000 cells/μL and a disease status of Rai classification stage I and Binet classification B...
2018: BMC Clinical Pathology
https://www.readbyqxmd.com/read/29740389/a-rare-case-of-composite-dural-extranodal-marginal-zone-lymphoma-and-chronic-lymphocytic-leukemia-small-lymphocytic-lymphoma
#4
REVIEW
Mark Bustoros, Benjamin Liechty, David Zagzag, Cynthia Liu, Timothy Shepherd, Deborah Gruber, Bruce Raphael, Dimitris G Placantonakis
Background: Primary extranodal marginal zone lymphoma (MZL) of the dura is a rare neoplastic entity in the central nervous system (CNS). Methods: We used literature searches to identify previously reported cases of primary dural MZL. We also reviewed clinical, pathologic, and radiographic data of an adult patient with concurrent dural MZL and chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL). Results: We identified 104 cases of dural MZL in the literature...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29725426/role-of-endoscopic-ultrasound-guided-fine-needle-aspiration-in-evaluating-mediastinal-and-intra-abdominal-lymphadenopathies-of-unknown-origin
#5
Jinlin Wang, Qian Chen, Xiaoli Wu, Yun Wang, Wei Hou, Bin Cheng
The aim of the present study was to evaluate the efficacy of endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) in diagnosing mediastinal and intra-abdominal lymphadenopathies. A total of 154 patients with mediastinal and intra-abdominal lymphadenopathies were included in this retrospective study between February 2010 and March 2015. Malignancy was suspected in the patients as a result of imaging findings and EUS-FNAs were performed to confirm the diagnoses. EUS and EUS-FNA data, as well as hospital medical records, were reviewed...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29668470/secondary-hodgkin-lymphoma-and-myelodysplastic-syndrome-mds-after-paclitaxel-carboplatin-treatment-in-a-patient-with-small-cell-lung-cancer
#6
Marija Petrusevska, Irina Panovska Stavridis, Kristina Mladenovska, Gordana Petrushevska
Herein synchronous occurrence of Hodgkin lymphoma and secondary myelodysplastic syndrome in a 60 year old male patient with small cell lung cancer treated with combined chemotherapy (carboplatin and paclitaxel) and radiotherapy is presented. The objective of this report is to stress the importance of documenting and monitoring adverse drug reactions that arise from chemotherapy. After four years of treatment with the combined chemotherapy, the patient presented inguinal lymphadenopathy and enlarged lymph nodes and histopathology rapport was suggestive for plasmacytoid variant of Castleman disease...
December 1, 2017: Prilozi (Makedonska Akademija Na Naukite i Umetnostite. Oddelenie za Medicinski Nauki)
https://www.readbyqxmd.com/read/29618693/-long-term-remission-with-mogamulizumab-monotherapy-in-a-patient-with-refractory-adult-t-cell-leukemia-lymphoma
#7
Yosuke Nakaya, Minako Tsutsumi, Hoyuri Fuseya, Mirei Horiuchi, Takuro Yoshimura, Yoshiki Hayashi, Hiroshi Kanashima, Takafumi Nakao, Takahisa Yamane
A 73-year-old female with malaise, anorexia, and hydrodipsia was referred to our department. Peripheral blood tests revealed leukocytosis with 51% blast cells exhibiting flower-shaped nuclei. Flow-cytometry to detect tumor cells in peripheral blood indicated CD3+, CD4+, CD8-, and CD25- expression, but those in the lymph nodes expressed CD25+. Southern blots revealed clonal HTLV-1 provirus in the tumor cells, consistent with adult T-cell leukemia-lymphoma. Cytotoxic chemotherapy was ineffective, but eight cycles of mogamulizumab induced complete remission (CR)...
2018: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/29571658/cryopreservation-of-testicular-tissue-in-pre-pubertal-and-adolescent-boys-at-risk-for-infertility-a-low-risk-procedure
#8
Jessica M Ming, Michael E Chua, Roberto Iglesias Lopes, Anne Marie Maloney, Abha A Gupta, Armando J Lorenzo
INTRODUCTION: Cryopreservation of testicular tissue (TT) has become an increasingly attractive option for fertility preservation (FP), particularly for pre-pubertal boys at risk for gonadotoxicity from cancer therapy. At our institution, all at-risk families undergo counseling regarding infertility risk and available FP strategies, including this vulnerable patient population. As the technology required to use the acquired tissue is, as yet, unproven, it is paramount to document minimal morbidity and complications from this procedure...
March 9, 2018: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29505472/cutaneous-t-cell-lymphoma-a-novel-manifestation-of-pdgfra-rearranged-neoplasm
#9
Amir Behdad, Pamela Allen, Xinyan Lu, Xiaolong Alan Zhou, Joan Guitart, Qing Chen, Barbara Pro
Patients with PDGFRA-rearranged hematopoietic neoplasms typically present with chronic eosinophilic leukemia and rarely with acute myeloid leukemia or T-lymphoblastic lymphoma. However, mature T-cell lymphoma has not been previously associated with PDGFRA aberrations. We report a patient who presented with simultaneous T-lymphoblastic lymphoma, focal myeloid proliferation, and cutaneous cytotoxic T-cell lymphoma refractory to chemotherapy. The presence of myeloid and lymphoid lineages prompted genetic and molecular studies...
February 21, 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29501750/mixed-phenotype-t-b-myeloid-extramedullary-blast-crisis-as-an-initial-presentation-of-chronic-myelogenous-leukemia
#10
Xin Qing, Annie Qing, Ping Ji, Samuel W French, Holli Mason
BACKGROUND: Chronic myelogenous leukemia (CML) is a myeloproliferative disorder characterized by the Philadelphia (Ph) chromosome generated by the reciprocal translocation t(9,22)(q34;q11). The natural progression of the disease follows a biphasic or triphasic course. Most cases of CML are diagnosed in the chronic phase. Extramedullary blast crisis rarely occurs during the course of CML, and is extremely rare as the initial presentation of CML. CASE PRESENTATION: Here, we report the case of a 32-year-old female with enlarged neck lymph nodes and fatigue...
April 2018: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/29491299/adult-t-cell-leukemia-lymphoma-as-a-methotrexate-associated-lymphoproliferative-disorder-in-a-patient-with-rheumatoid-arthritis-a-case-report
#11
Ichiro Takajo, Kunihiko Umekita, Yoshihiko Ikei, Koichi Oshima, Akihiko Okayama
The patient was a 74-year-old Japanese woman with rheumatoid arthritis (RA) who developed generalized lymphadenopathy with elevated levels of lactase dehydrogenase (LD), and soluble IL-2 receptor (sIL-2R). She was found to be positive for anti-human T-cell leukemia virus type 1 (HTLV-1) antibodies. Her symptoms and laboratory abnormalities spontaneously regressed after the cessation of methotrexate (MTX), suggesting that she had an MTX-associated lymphoproliferative disorder; however, her lymphadenopathy appeared again approximately 14 months later with LD and sIL-2R elevation...
February 28, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29487747/extranodal-non-b-non-t-cell-lymphoma-with-bilateral-tympanic-bulla-involvement-in-a-cat
#12
Austin T Kerns, Kelsey A Brakel, Christopher Premanandan, Ashlie Saffire, Sarah A Moore
Case summary: A 9-year-old spayed female domestic shorthair cat with clinical signs suggestive of chronic recurrent otitis media and recent seizures was presented with multifocal nervous system disease, including bilateral central and/or peripheral vestibular, cerebellar and forebrain deficits. Prior to presentation, there was inadequate improvement after 6 weeks of treatment for bilateral middle ear effusion from which a highly susceptible Staphylococcus species was cultured. This was followed by the development of seizures...
January 2018: JFMS Open Reports
https://www.readbyqxmd.com/read/29483496/comparison-of-chromosomal-rearrangements-in-bone-marrow-cells-and-blast-transformed-b-cells-in-relapse-of-b-cell-chronic-lymphocytic-leukemia-small-lymphocytic-lymphoma
#13
S V Andreieva, K V Korets, O E Ruzhinska, I M Skorokhod, O G Alkhimova
AIM: The genetic mechanisms of resistance to chemotherapy in B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma (B-CLL/SLL) are not clear. We aimed to determine the peculiarities of abnormal karyotype formation in bone marrow (BM) cells and peripheral blood (PB) blast transformed B-cells in relapse of B-CLL/SLL. MATERIALS AND METHODS: Cytogenetic GTG banding technique and molecular cytogenetic in interphase cells (i-FISH) studies of BM cells and PB blast transformed B-lymphocytes were performed in 14 patients (10 males and 4 females) with B-CLL/SLL...
July 2017: Experimental Oncology
https://www.readbyqxmd.com/read/29470582/prognostic-factors-for-complete-response-to-ibrutinib-in-patients-with-chronic-lymphocytic-leukemia-a-pooled-analysis-of-2-clinical-trials
#14
Susan M O'Brien, Samantha Jaglowski, John C Byrd, Rajat Bannerji, Kristie A Blum, Christopher P Fox, Richard R Furman, Peter Hillmen, Thomas J Kipps, Marco Montillo, Jeff Sharman, Sam Suzuki, Danelle F James, Alvina D Chu, Steven E Coutre
Importance: Ibrutinib, a first-in-class Bruton tyrosine kinase inhibitor taken once daily, is approved in the United States for patients with chronic lymphocytic leukemia/small lymphocytic lymphoma and allows for treatment without chemotherapy. Extended treatment with ibrutinib has demonstrated increased complete response (CR) rates over time. Objective: To analyze baseline factors that predict CR in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma treated with ibrutinib...
February 22, 2018: JAMA Oncology
https://www.readbyqxmd.com/read/29449436/mixed-species-rnaseq-analysis-of-human-lymphoma-cells-adhering-to-mouse-stromal-cells-identifies-a-core-gene-set-that-is-also-differentially-expressed-in-the-lymph-node-microenvironment-of-mantle-cell-lymphoma-and-chronic-lymphocytic-leukemia-patients
#15
Gustav Arvidsson, Johan Henriksson, Birgitta Sander, Anthony P Wright
A subset of hematologic cancer patients is refractory to treatment or suffers relapse, due in part to minimal residual disease, whereby some cancer cells survive treatment. Cell-adhesion-mediated drug resistance is an important mechanism, whereby cancer cells receive survival signals via interaction with e.g. stromal cells. No genome-wide studies of in vitro systems have yet been performed to compare gene expression in different cell subsets within a co-culture and cells grown separately. Using RNA sequencing and species-specific read mapping, we compared transcript levels in human Jeko-1 mantle cell lymphoma cells stably adhered to mouse MS-5 stromal cells or in suspension within a co-culture or cultured separately as well as in stromal cells in co-culture or in separate culture...
April 2018: Haematologica
https://www.readbyqxmd.com/read/29434969/a-unique-bone-marrow-lymphoma-patient-presenting-with-an-isolated-mass-a-case-report
#16
Yi-Wen Xu, Ming-Hui Duan
Bone marrow lymphoma with the onset of an isolated mass in the bone marrow is extremely rare. The present case report described a unique case of B cell lymphoblastic lymphoma (LBL) presenting with an isolated mass in the bone marrow cavity, without any organopathy or lymphadenopathy. An isolated mass in bone marrow is a rare primary manifestation of LBL. The patient in the present case report presented with pain in the right elbow, a fever, pancytopenia and splenomegaly. Additionally, no abnormality was determined in the lymph nodes, the bone marrow karyotype or a computed tomography scan of the humerus...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29419478/-18-f-fludarabine-pet-for-lymphoma-imaging-first-in-man-study-in-dlbcl-and-cll-patients
#17
Sylvain Chantepie, Narinée Hovhannisyan, Stéphane Guillouet, Jean-Pierre Pelage, Méziane Ibazizene, Caroline Bodet-Milin, Thomas Carlier, Anne-Claire Gac, Emilie Réboursière, Jean-Pierre Vilque, Françoise Kraeber-Bodéré, Alain Manrique, Gandhi Damaj, Michel Leporrier, Louisa Barré
This is the first in-man clinical study of 18 F-fludarabine which is a radiopharmaceutical for PET imaging in lymphoma where many issues remain controversial with the standard radiotracer 18 F-FDG. Methods: 18 F-Fludarabine-PET(/CT) was performed in 10 patients: five with diffuse large B-cell lymphoma (DLBCL) and five with chronic lymphocytic leukemia (CLL). The biodistribution, and radiation dosimetry of 18 F-fludarabine have also been evaluated. Six successive partial body PET scans were acquired for 250 min after intravenous 4 MBq/kg bolus of 18 F-fludarabine...
February 1, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29397833/-c-myc-gene-and-protein-expression-in-paraffin-wax-of-t-lymphoblastic-lymphoma-and-leukemia-patients-and-its-effect-on-the-prognosis
#18
Xiao-Dong Zhang, Li-Ming He, Lei Ma, Zhang-Guo Chang
OBJECTIVE: To explore the relevance between the expression of C-MYC gene and protein of patients with T lymphoblastic lymphoma and leukemia(T-LBL/ALL) and its effect on the prognosis. METHODS: Paraffin specimens from 60 cases of T-LBL/ALL with detailed follow-up during May 2005 to May 2016 were selected as study group; at same time 20 cases of reactive hyperplasia (RH) of lymphonuedes were selected as control group. The immunohistochemical EnVision method was used to mark the terminal deoxynucleotidyl transferase (TDT), myeloperoxidase (MPO), Ki-67 and C-MYC immune tissue...
February 2018: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/29396936/flow-cytometry-in-pediatric-malignancies
#19
Anil Handoo, Tina Dadu
The utility of flow cytometry as a useful diagnostic modality for the assessment of hematopoietic neoplasms has been established beyond doubt. In fact, it is now an integral part of the diagnosis and classification of various diseases like leukemias and lymphomas along with molecular studies and cytogenetics. Prognostication and disease monitoring by flow cytometry is also being recognized increasingly as one of the important fortes. This is evident by the number of articles in the published in literature on the minimal residual disease detection by flow cytometry especially in the last decade or so...
January 15, 2018: Indian Pediatrics
https://www.readbyqxmd.com/read/29341235/concomitant-cutaneous-squamous-cell-carcinoma-and-chronic-lymphocytic-leukemia-in-a-patient-the-utility-of-18-f-fdg-pet-ct-in-differentiation-of-nodal-metastasis
#20
Kerem Ozturk, Celalettin Ustun, Sobia Khaja, Faqian Li, Matthew Rischall, Zuzan Cayci
No abstract text is available yet for this article.
January 17, 2018: American Journal of Hematology
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