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https://www.readbyqxmd.com/read/28817303/chrna7-deletions-are-enriched-in-risperidone-treated-children-and-adolescents
#1
Madelyn A Gillentine, Janson J White, Christopher M Grochowski, James R Lupski, Christian P Schaaf, Chadi A Calarge
OBJECTIVE: Aggression is among the most common indications for referral to child and adolescent mental health services and is often challenging to treat. Understanding the biological underpinnings of aggression could help optimize treatment efficacy. Neuronal nicotinic acetylcholine receptors (nAChRs), specifically the α7 nAChR, encoded by the gene CHRNA7, have been implicated in aggressive behaviors in animal models as well as humans. Copy number variants (CNVs) of CHRNA7 are found in individuals with neuropsychiatric disorders, often with comorbid aggression...
August 17, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28816982/performance-of-procalcitonin-in-diagnosing-parapneumonic-pleural-effusions-a-clinical-study-and-meta-analysis
#2
Chao He, Bo Wang, Danni Li, Huan Xu, Yongchun Shen
BACKGROUND: Parapneumonic pleural effusion (PPE) is a common complication of pneumonia. The accurate diagnosis of PPE remains a challenge. Recent studies suggest that procalcitonin (PCT) emerges as a potential biomarker for PPE. Our study aimed to determine the diagnostic value of PCT for PPE by a clinical study and summarize the overall diagnostic performance of PCT through a meta-analysis. METHODS: Demographic and clinical data of the patients with PPE and controls were collected in our clinical study...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28815388/guiding-patients-toward-the-appropriate-surgical-treatment-for-obesity-should-presurgery-psychological-correlates-influence-choice-between-roux-en-y-gastric-bypass-and-vertical-sleeve-gastrectomy
#3
Gretchen E Ames, Michael G Heckman, Nancy N Diehl, Dustin M Shepherd, Allison A Holgerson, Karen B Grothe, Todd A Kellogg, Steven P Bowers, Matthew M Clark
BACKGROUND: Helping patients determine which type of bariatric surgery, Roux-en-Y gastric bypass (RYGB) or vertical sleeve gastrectomy (VSG), may be the best treatment can be challenging. This study investigated psychological correlates and their influence on weight loss for patients who underwent RYGB or VSG. METHODS: Four hundred twenty-two patients (RYGB = 305; VSG = 117) completed screening questionnaires presurgery and underwent surgery between August 2012 and April 2015...
August 16, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28815145/evolving-research-data-sharing-networks-to-clinical-app-sharing-networks
#4
Kavishwar B Wagholikar, Rahul Jain, Eliel Oliveira, Joshua Mandel, Jeffery Klann, Ricardo Colas, Prasad Patil, Kuladip Yadav, Kenneth D Mandl, Thomas Carton, Shawn N Murphy
Research networks for data sharing are growing into a large platform for pragmatic clinical trials to generate quality evidence for shared medical decision-making. Institutions partnering in the networks have made large investments in developing the infrastructure for sharing data. We investigate whether institutions partnering on Patient-Centered Outcomes Research Institute's (PCORI) network can share clinical apps. At two different sites, we imported patient data in PCORI's clinical data model (CDM) format into i2b2 repositories, and adapted the SMART-on-FHIR cell to perform CDM-to-FHIR translation, serving demographics, laboratory results and diagnoses...
2017: AMIA Summits on Translational Science Proceedings
https://www.readbyqxmd.com/read/28812567/high-taxonomic-variability-despite-stable-functional-structure-across-microbial-communities
#5
Stilianos Louca, Saulo M S Jacques, Aliny P F Pires, Juliana S Leal, Diane S Srivastava, Laura Wegener Parfrey, Vinicius F Farjalla, Michael Doebeli
Understanding the processes that are driving variation of natural microbial communities across space or time is a major challenge for ecologists. Environmental conditions strongly shape the metabolic function of microbial communities; however, other processes such as biotic interactions, random demographic drift or dispersal limitation may also influence community dynamics. The relative importance of these processes and their effects on community function remain largely unknown. To address this uncertainty, here we examined bacterial and archaeal communities in replicate 'miniature' aquatic ecosystems contained within the foliage of wild bromeliads...
December 5, 2016: Nature ecology & evolution
https://www.readbyqxmd.com/read/28810974/factors-affecting-organizational-commitment-in-navy-corpsmen
#6
Stephanie Booth-Kewley, Renée G Dell'Acqua, Cynthia J Thomsen
BACKGROUND: Organizational commitment is a psychological state that has a strong impact on the likelihood that employees will remain with an organization. Among military personnel, organizational commitment is predictive of a number of important outcomes, including reenlistment intentions, job performance, morale, and perceived readiness. Because of the unique challenges and experiences associated with military service, it may be that organizational commitment is even more critical in the military than in civilian populations...
July 2017: Military Medicine
https://www.readbyqxmd.com/read/28807361/challenges-to-treating-older-glioblastoma-patients-the-influence-of-clinical-and-tumour-characteristics-on-survival-outcomes
#7
C F Lorimer, C Hanna, F Saran, A Chalmers, J Brock
AIMS: There is now evidence to support giving single-agent chemotherapy, radiotherapy or hypofractionated concurrent chemoradiotherapy to older patients with glioblastoma (GBM). However, the clinical basis on which treatment decisions are made is under-researched and not standardised. This retrospective, multicentre study assessed whether pre-morbid characteristics or tumour imaging features could predict for overall survival in a cohort of older patients with GBM. MATERIALS AND METHODS: Patients aged > 70 years, diagnosed with GBM at three neuro-oncology centres from 2010 to 2015 were retrospectively analysed...
August 11, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/28807252/role-of-hepatic-trisectionectomy-in-advanced-hepatocellular-carcinoma
#8
J S Tsang, K S H Chok, C M Lo
BACKGROUND: Advanced hepatocellular carcinoma (HCC) with underlying cirrhosis poses a major operative challenge. Patients have a dismal prognosis without curative resection. The role of hepatic trisectionectomy in these patients is not established. The aim of this study was to analyze and compare the perioperative outcome and prognosis of patients undergoing trisectionectomy with hepatic resection of a lesser extent. METHODS: From 2000 to 2014, 48 patients underwent hepatic trisectionectomy for HCC with background cirrhosis or chronic hepatitis (Group A)...
September 2017: Surgical Oncology
https://www.readbyqxmd.com/read/28807192/does-compliance-with-antibiotic-prophylaxis-in-pediatric-simple-appendicitis-matter
#9
Krislynn M Mueck, Luke R Putnam, Kathryn T Anderson, Kevin P Lally, KuoJen Tsao, Lillian S Kao
BACKGROUND: Institutional protocols for preincisional antibiotic prophylaxis can standardize care and improve outcomes. However, challenges remain in compliance with such protocols for urgent or emergent operations. We hypothesized that compliance with an institutional protocol for antibiotic prophylaxis for appendectomy for appendicitis in pediatric patients results in reduced surgical site infections (SSIs) after simple appendectomy. METHODS: This retrospective study assessed all pediatric patients (≤18 y) who underwent appendectomy for confirmed simple appendicitis at a tertiary children's hospital between 2012 and 2015...
August 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28806490/challenges-and-resources-for-nurses-participating-in-a-hurricane-sandy-hospital-evacuation
#10
Nancy VanDevanter, Victoria H Raveis, Christine T Kovner, Meriel McCollum, Ronald Keller
PURPOSE: Weather-related disasters have increased dramatically in recent years. In 2012, severe flooding as a result of Hurricane Sandy necessitated the mid-storm patient evacuation of New York University Langone Medical Center. The purpose of this study was to explore, from the nurses' perspective, what the challenges and resources were to carrying out their responsibilities, and what the implications are for nursing education and preparation for disaster. DESIGN: This mixed-methods study included qualitative interviews with a purposive sample of nurses and an online survey of nurses who participated in the evacuation...
August 14, 2017: Journal of Nursing Scholarship
https://www.readbyqxmd.com/read/28804983/a-longitudinal-study-of-the-profiles-of-psychological-thriving-resilience-and-loss-in-people-with-inflammatory-bowel-disease
#11
Fuschia M Sirois, Jameson K Hirsch
OBJECTIVES: Despite the toll of inflammatory bowel disease (IBD) on adjustment, many patients are resilient to the challenges associated with living with IBD, and successfully cope with their illness and thrive. Yet there is little research on why some individuals with IBD enter a trajectory of growth, while others may struggle to adapt. The aim of this study was to investigate the adjustment-related factors that distinguished thriving, resilience, and loss in people with IBD across personal growth, life satisfaction, and relationship quality domains...
August 14, 2017: British Journal of Health Psychology
https://www.readbyqxmd.com/read/28803597/somali-latino-and-hmong-parents-perceptions-and-approaches-about-raising-healthy-weight-children-a-community-based-participatory-research-study
#12
Chrisa Arcan, Kathleen A Culhane-Pera, Shannon Pergament, Maira Rosas-Lee, Mai Bao Xiong
OBJECTIVE: Immigrants in the USA are confronted with health disparities, including childhood obesity and obesity-related chronic diseases. We aimed to identify perceptions of childhood body weight, approaches to raising healthy children and desires for supportive programmes of Somali, Latino and Hmong (SLM) parents in the Twin Cities, Minnesota, USA. DESIGN: Using community-based participatory research, ten focus groups (FG) were conducted with sixty-seven parents (n 28 Somali, three FG; n 19 Latino, four FG; n 20 Hmong, three FG) of 3-12-year-old children in their native language...
August 14, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/28803583/cross-sectional-survey-of-long-term-care-facilities-in-the-rockaway-peninsula-preparedness-and-response-during-hurricane-sandy
#13
Lynn Jiang, Christopher Tedeschi, Saleena Subaiya
BACKGROUND: Few studies have described the challenges experienced by long-term care facilities (LTCFs) following Hurricane Sandy. This study examined LTCF preparedness and experiences during and after the storm. METHODS: A cross-sectional survey was conducted 2 years after Hurricane Sandy to assess LTCF demographics, preparation, and post-storm resources. Surveys were conducted at LTCFs located on the Rockaway Peninsula of New York City. All LTCFs located in a heavily affected area were approached...
August 14, 2017: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/28802084/the-parameters-that-help-to-differentiate-biliary-atresia-from-other-diseases
#14
Makoto Hayashida, Toshiharu Matsuura, Yoshiaki Kinoshita, Genshiro Esumi, Koichiro Yoshimaru, Yusuke Yanagi, Yoshiaki Takahashi, Tomoaki Taguchi
BACKGROUND: The diagnosis of biliary atresia (BA) is still challenging. The aim of this study was to analyze the clinical features and parameters that contribute to a diagnosis of BA. METHODS: From January 2000 to December 2013, 37 patients who underwent operative cholangiography were evaluated retrospectively. The patients were divided into two groups: a BA group, and a group with other cholestatic diseases (non-BA group). The demographic data and preoperative liver function test results were analyzed...
August 12, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28800879/the-association-between-fruit-and-vegetable-consumption-and-fruit-and-vegetable-stage-of-change-in-underserved-communities-engaging-with-cooperative-extension-services
#15
Shannon M Robson, Elizabeth Orsega-Smith, Katie Greenawalt, P M Peterson
OBJECTIVE: To compare differences in fruit and vegetable (FV) intake and FV stage of change in 2 diverse communities engaging with cooperative extension services (Extension). METHODS: Cross-sectional study of FV behaviors of community members enrolled in a team-based challenge offered by Extension. t test and chi-square analyses examined differences in FV intake and FV stage of change. Linear regression examined the relationship between FV stage of change and FV intake, adjusting for demographics...
August 8, 2017: Journal of Nutrition Education and Behavior
https://www.readbyqxmd.com/read/28799157/-social-medicine-and-interfaces-in-sectoral-health-care-provision
#16
Hans Gerber, Christian Alex, Michael Penz, Michael Röder, Gert von Mittelstaedt
In addition to the consideration of individual medicine, social medicine focuses on the social references of health and sickness. In this context, it reflects the structures of the entire health care system, its functions and its functional deficits. It deals with the specific interaction between medicine and society and functions such as a link to the classical social sciences (1). Of particular interest in this context are the interfaces to sectoral health care provision. The working group "Nursing Care" of the Department "Practical Social Medicine and Rehabilitation" of the German Society for Social Medicine and Prevention examines the fundamental interfaces in our sectoral health care system from the perspective of social medicine in their current functions and perspectives, particularly in view of the future demographic challenges to be faced...
August 10, 2017: Das Gesundheitswesen
https://www.readbyqxmd.com/read/28798367/epidemiology-of-tuberculosis-in-chongqing-china-a-secular-trend-from-1992-to-2015
#17
Bo Wu, Ya Yu, Weijia Xie, Ying Liu, Yao Zhang, Daiyu Hu, Yafei Li
Chongqing is a southwest city of China with high tuberculosis (TB) burden. An observational retrospective study has been performed based on routine TB surveillance data in Chongqing from 1992 to 2015. The TB notification rate has declined to 70.8 cases per 100,000 population from the peak of 106 cases per 100,000 in 2005. The TB notification rate in population over-65 years has become the highest among all-ages population since 2010. The average proportion of farmers in all notified cases from 2008 to 2015 was 62...
August 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28797645/advance-directives-in-hospice-healthcare-providers-a-clinical-challenge
#18
George R Luck, Terry Eggenberger, David Newman, Jacqueline Cortizo, Derek C Blankenship, Charles H Hennekens
BACKGROUND: On a daily basis, healthcare providers, especially those dealing with terminally ill patients, such as hospice workers, witness how advance directives help ensure the wishes of patients. They also witness the deleterious consequences when patients fail to document the care they desire at their end of life. To the best of our knowledge there are no data concerning the prevalence of advance directives among hospice healthcare providers. We, therefore, explored the prevalence and factors influencing completion rates in a survey of hospice healthcare providers...
August 7, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28796982/-causes-of-death-in-children-and-adolescents-aged-1-19-in-poland-in-the-light-of-international-statistics-since-2000
#19
Joanna Mazur, Marta Malinowska-Cieślik, Anna Oblacińska
BACKGROUND: Analyses of children and young people mortality continue to be an important component of health monitoring of this population. Such analyses provide the basis to assess the overall trends, the structure of the causes of death over longer periods, and the differences between Poland and other countries. PURPOSE: The purpose of the current study is to present the current status and the direction of changes since 2000 with regard to the level and underlying causes of mortality in children and adolescents aged 1-19 years in Poland on the background of statistics for leading European countries...
2017: Developmental Period Medicine
https://www.readbyqxmd.com/read/28795921/health-at-the-borders-bayesian-multilevel-analysis-of-women-s-malnutrition-determinants-in-ethiopia
#20
Tefera Darge Delbiso, Jose Manuel Rodriguez-Llanes, Chiara Altare, Bruno Masquelier, Debarati Guha-Sapir
Background Women's malnutrition, particularly undernutrition, remains an important public health challenge in Ethiopia. Although various studies examined the levels and determinants of women's nutritional status, the influence of living close to an international border on women's nutrition has not been investigated. Yet, Ethiopian borders are regularly affected by conflict and refugee flows, which might ultimately impact health. Objective To investigate the impact of living close to borders in the nutritional status of women in Ethiopia, while considering other important covariates...
December 2016: Global Health Action
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