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https://www.readbyqxmd.com/read/28238744/peanut-allergen-threshold-study-pats-novel-single-dose-oral-food-challenge-study-to-validate-eliciting-doses-in-peanut-allergic-children
#1
Jonathan O'B Hourihane, Katrina J Allen, Wayne G Shreffler, Gillian Dunngalvin, Julie A Nordlee, Giovanni A Zurzolo, Audrey DunnGalvin, Lyle C Gurrin, Joseph L Baumert, Steve L Taylor
BACKGROUND: Eliciting doses (ED) of allergenic foods can be defined by the distribution of threshold doses for individuals within a specific population. ED05 is the dose that elicits a reaction in 5% of allergic subjects. The predicted ED05 for peanut (PN) is 1.5 mg of peanut protein (6 mg whole peanut). OBJECTIVE: We sought to validate the predicted peanut ED05 (1.5 mg) with a novel single dose challenge. METHODS: Consecutive eligible peanut allergic children in 3 centres were prospectively invited to participate, irrespective of previous reaction severity...
February 24, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28238508/using-a-multidimensional-prognostic-index-mpi-based-on-comprehensive-geriatric-assessment-cga-to-predict-mortality-in-elderly-undergoing-transcatheter-aortic-valve-implantation
#2
Marie-Laure Bureau, Evelyne Liuu, Luc Christiaens, Alberto Pilotto, Jean Mergy, Fabienne Bellarbre, Pierre Ingrand, Marc Paccalin
BACKGROUND: Selection of appropriate elderly who can benefit from transcatheter aortic valve implantation (TAVI) is challenging. We evaluated the prognosis of this procedure according to the comprehensive geriatric assessment (CGA) based on the multidimensional prognostic index (MPI). METHODS: Prospective observational monocentric study from January 2013 to December 2015. Consecutive patients aged ≥75 who underwent TAVI and a complete CGA were included. Baseline demographic, geriatric and cardiologic data were collected...
February 16, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28237772/factors-related-to-shunt-survival-in-paediatric-hydrocephalus-could-failure-be-avoided
#3
Sara Iglesias, Bienvenido Ros, Álvaro Martín, Antonio Carrasco, Miguel Segura, Angela Ros, Francisca Rius, Miguel Ángel Arráez
BACKGROUND: Improved shunt survival and a better understanding of factors related to failure in paediatric hydrocephalus still pose a challenge for neurosurgeons, in order to avoid morbidity and mortality, as well as the economic impact of repeated revision surgeries. For these reasons, an analysis is performed on the factors related to the first shunt failure in the long-term follow-up of a series in a single centre. METHODS: A retrospective review was conducted on 166 hydrocephalic paediatric patients shunted for the first time between 2000 and 2014...
February 22, 2017: Neurocirugía
https://www.readbyqxmd.com/read/28237388/using-administrative-data-to-look-at-changes-in-the-level-and-distribution-of-out-of-pocket-medical-expenditure-an-example-using-medicare-data-from-australia
#4
Xinyang Hua, Guido Erreygers, John Chalmers, Tracey-Lea Laba, Philip Clarke
OBJECTIVES: Australia's universal health insurance system Medicare generates very large amounts of data on out-of-pocket expenditure (OOPE), but only highly aggregated statistics are routinely published. Our primary purpose is to develop indices from the Medicare administrative data to quantify changes in the level and distribution of OOPE on out-of-hospital medical services over time. METHODS: Data were obtained from the Australian Hypertension and Absolute Risk Study, which involved patients aged 55 years and over (n=2653)...
February 22, 2017: Health Policy
https://www.readbyqxmd.com/read/28237131/diagnostic-values-for-egg-white-specific-ige-levels-with-the-skin-prick-test-in-turkish-children-with-egg-white-allergy
#5
H T Nacaroglu, S B Erdem, S Karaman, D Dogan, C S U Karkiner, E T Kanık, D Can
BACKGROUND: The diagnostic values for the skin prick test (SPT) diameters and egg white-specific IgE (EW-sIgE) levels that will allow us to predict the result of the oral food challenge test (OFC) in the diagnosis of egg white allergy vary by the community where the study is carried out. OBJECTIVE: This study aimed to determine the diagnostic values of SPT and EW-sIgE levels in the diagnosis of egg white allergy. METHODS: 59 patients followed with the diagnosis of egg allergy September 2013 to September 2015 were included in our retrospective cross-sectional study...
February 22, 2017: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/28236337/trends-in-operative-vaginal-delivery-2005-2013-a-population-based-study
#6
A A Merriam, C V Ananth, J D Wright, Z Siddiq, M E D'Alton, A M Friedman
OBJECTIVE: The objectives of this study were to determine temporal trends in forceps and vacuum delivery and factors associated with operative vaginal delivery. DESIGN: Retrospective cohort. SETTING: Population-based study of US birth records. POPULATION: US births from 2005 to 2013. METHODS: This study evaluated forceps and vacuum extraction during vaginal delivery in live-born, non-anomalous singleton gestations from ≥ 36 to < 42 weeks of gestation...
February 25, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28235750/the-state-of-open-source-electronic-health-record-projects-a-software-anthropology-study
#7
Mona Alsaffar, Peter Yellowlees, Alberto Odor, Michael Hogarth
BACKGROUND: Electronic health records (EHR) are a key tool in managing and storing patients' information. Currently, there are over 50 open source EHR systems available. Functionality and usability are important factors for determining the success of any system. These factors are often a direct reflection of the domain knowledge and developers' motivations. However, few published studies have focused on the characteristics of free and open source software (F/OSS) EHR systems and none to date have discussed the motivation, knowledge background, and demographic characteristics of the developers involved in open source EHR projects...
February 24, 2017: JMIR Medical Informatics
https://www.readbyqxmd.com/read/28231421/varying-demographic-impacts-of-different-fisheries-on-three-mediterranean-seabird-species
#8
M Genovart, D Doak, J M Igual, S Sponza, J Kralj, D Oro
Fisheries have an enormous economic importance but reconciling their socio-economic features with the conservation and sustainability of marine ecosystems presents major challenges. Bycatch mortality from fisheries is clearly among the most serious global threats for marine ecosystems, affecting a wide range of top predators. Recent estimates report ca. 200,000 seabirds killed annually by bycatch in European waters. However there is an urgent need to rigorously estimate actual mortality rates and quantify effects of bycatch on populations...
February 23, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28231283/rapid-evolution-of-distinct-helicobacter-pylori-subpopulations-in-the-americas
#9
Kaisa Thorell, Koji Yahara, Elvire Berthenet, Daniel J Lawson, Jane Mikhail, Ikuko Kato, Alfonso Mendez, Cosmeri Rizzato, María Mercedes Bravo, Rumiko Suzuki, Yoshio Yamaoka, Javier Torres, Samuel K Sheppard, Daniel Falush
For the last 500 years, the Americas have been a melting pot both for genetically diverse humans and for the pathogenic and commensal organisms associated with them. One such organism is the stomach-dwelling bacterium Helicobacter pylori, which is highly prevalent in Latin America where it is a major current public health challenge because of its strong association with gastric cancer. By analyzing the genome sequence of H. pylori isolated in North, Central and South America, we found evidence for admixture between H...
February 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28229808/knowledge-of-behavioural-management-principles-amongst-specialist-paediatric-dental-practitioners-in-the-united-kingdom
#10
James Coxon, Marie Therese Hosey, J Tim Newton
BACKGROUND: Paediatric specialist dental practitioners are often faced with the challenge of disruptive behaviour or refusal to comply with treatment. Behaviour management skills are an essential component of their role. However, little is known of the confidence or competence of practitioners in these approaches. AIM: To identify paediatric dentists' knowledge of behavioural management principles as applied to paediatric dentistry. METHOD: Postal questionnaire survey of all specialists in Paediatric Dentistry on the General Dental Council UK register (n = 234), using the Knowledge of Behavioural Principles as Applied to Children Questionnaire (KBPACQ; O'Dell, 1979) adapted for the dental setting...
March 2017: Behavioural and Cognitive Psychotherapy
https://www.readbyqxmd.com/read/28228976/facebook-enables-disaster-research-studies-the-use-of-social-media-to-recruit-participants-in-a-post-disaster-setting
#11
Karin Hugelius, Annsofie Adolfsson, Mervyn Gifford, Per Örtenwall
INTRODUCTION: Disaster research entails several methodological challenges, given the context of a disaster. This article aims to describe and evaluate the use of Facebook as a tool to recruit participants for a self-selected Internet sample using a web-based survey in a post-disaster setting in the Philippines after the Haiyan typhoon hit parts of the country in November 2013. METHOD: An invitation to a web-based survey about health was posted on several Facebook pages during a ten-day period...
January 19, 2017: PLoS Currents
https://www.readbyqxmd.com/read/28226613/using-demographic-and-time-series-physiological-features-to-classify-sepsis-in-the-intensive-care-unit
#12
Kristin Gunnarsdottir, Vijay Sadashivaiah, Matthew Kerr, Sabato Santaniello, Sridevi V Sarma, Kristin Gunnarsdottir, Vijay Sadashivaiah, Matthew Kerr, Sabato Santaniello, Sridevi V Sarma, Sridevi V Sarma, Sabato Santaniello, Kristin Gunnarsdottir, Matthew Kerr, Vijay Sadashivaiah
Sepsis, a systemic inflammatory response to infection, is a major health care problem that affects millions of patients every year in the intensive care units (ICUs) worldwide. Despite the fact that ICU patients are heavily instrumented with physiological sensors, early sepsis detection remains challenging, perhaps because clinicians identify sepsis by (i) using static scores derived from bed-side measurements individually, and (ii) deriving these scores at a much slower rate than the rate for which patient data is collected...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28225781/chronic-pain-depression-and-cardiovascular-disease-linked-through-a-shared-genetic-predisposition-analysis-of-a-family-based-cohort-and-twin-study
#13
Oliver van Hecke, Lynne J Hocking, Nicola Torrance, Archie Campbell, Sandosh Padmanabhan, David J Porteous, Andrew M McIntosh, Andrea V Burri, Haruka Tanaka, Frances M K Williams, Blair H Smith
BACKGROUND: Depression and chronic pain are the two most important causes of disability (Global Burden of Disease Study 2013). They occur together more frequently than expected and both conditions have been shown to be co-morbid with cardiovascular disease. Although shared socio-demographic risk factors (e.g. gender, deprivation) might explain the co-morbidity of these three conditions, we hypothesised that these three long-term, highly prevalent conditions co-occur and may be due to shared familial risk, and/or genetic factors...
2017: PloS One
https://www.readbyqxmd.com/read/28225467/comparison-of-anesthetic-management-and-outcomes-in-patients-having-either-transnasal-or-transoral-endoscopic-odontoid-process-surgery
#14
Matthew A Sexton, Arnoley S Abcejo, Jeffrey J Pasternak
BACKGROUND: Endoscopic neurosurgical procedures involving the upper cervical vertebrae are challenging due to a narrow operating field and close proximity to vital anatomical structures. Historically, transoropharyngeal (transoral) endoscopy has been the preferred approach. More recently, however, an endoscopic transnasal approach was developed as an alternative method in hopes to reduce postoperative dysphagia, a common complication following transoral neurosurgery. METHODS: Twenty-two endoscopic neurosurgical cases involving the odontoid or C1 vertebra were reviewed between January 1, 2005 and December 31, 2015 (17 and 5 through transoral and transnasal approaches, respectively)...
February 20, 2017: Journal of Neurosurgical Anesthesiology
https://www.readbyqxmd.com/read/28222340/a-comparative-retrospective-exploration-of-the-profiles-of-patients-in-south-africa-diagnosed-with-epileptic-and-psychogenic-non-epileptic-seizures
#15
David G Anderson, Maria Damianova, Skye Hanekom, Marilyn Lucas
Psychogenic non-epileptic seizures (PNES) have a high prevalence globally but the accurate diagnosis of this condition still remains a challenge. This is particularly the case in countries where there is scarce expertise and insufficient affordable medical facilities to which patients have access. The rate of PNES diagnosis in epilepsy units is typically within the range of 20 to 30%. In the context of developing countries, this rate tends to be higher and increases demand on the existing scarce health care capacities...
February 18, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28221872/analysis-of-food-safety-and-security-challenges-in-emerging-african-food-producing-areas-through-a-one-health-lens-the-dairy-chains-in-mali
#16
Rachel Cheng, Alberto Mantovani, Chiara Frazzoli
Challenges posed by changes in livestock production in emerging food producing areas and demographic development and climate change require new approaches and responsibilities in the management of food chains. The increasingly recognized role of primary food producers requires the support of the scientific community to instruct effective approaches based on scientific data, tools, and expertise. Mali is an emerging food producing area, and this review covers (i) the dairy farming scenario and its environment, (ii) the role of dairy production in food security, including the greatly different animal rearing systems in the Sahel and tropical regions, (iii) risk management pillars as modern infrastructures, effective farmer organizations, and institutional systems to guarantee animal health and safety of products, and (iv) feasible interventions based on good practices and risk assessment at the farm level (e...
January 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28221274/pharmacy-use-in-the-first-year-of-the-veterans-choice-program-a-mixed-methods-evaluation
#17
Walid F Gellad, Francesca E Cunningham, Chester B Good, Joshua M Thorpe, Carolyn T Thorpe, Brandi Bair, KatieLynn Roman, Susan L Zickmund
BACKGROUND: The Veterans Choice Program (VCP) was created to ensure timely access to health care in the Department of Veterans Affairs (VA). Under this program, medications may be ordered by select non-VA clinicians to be dispensed by VA pharmacies, creating new challenges in ensuring medication safety. OBJECTIVES: To examine pharmaceutical use during the first year of the VCP and to understand barriers and facilitators for VA pharmacists to dispensing medications under the VCP...
February 17, 2017: Medical Care
https://www.readbyqxmd.com/read/28221186/evaluation-of-electronic-health-record-implementation-in-hospitals
#18
Ahmad Tubaishat
The effectiveness of electronic health records has not previously been widely evaluated. Thus, this national cross-sectional study was conducted to evaluate electronic health records, from the perspective of nurses, by examining how they use the records, their opinions on the quality of the systems, and their overall levels of satisfaction with electronic health records. The relationship between these constructs was measured, and its predictors were investigated. A random sample of Jordanian hospitals that used electronic health records was selected, and data were gathered using a self-administered questionnaire, based on the DeLone and McLean Information Systems Success model...
February 17, 2017: Computers, Informatics, Nursing: CIN
https://www.readbyqxmd.com/read/28219879/use-of-online-forums-for-perinatal-mental-illness-stigma-and-disclosure-an-exploratory-model
#19
Donna Moore, Nicholas Drey, Susan Ayers
BACKGROUND: Perinatal mental illness is a global health concern; however, many women with the illness do not get the treatment they need to recover. Interventions that reduce the stigma around perinatal mental illness have the potential to enable women to disclose their symptoms to health care providers and consequently access treatment. There are many online forums for perinatal mental illness and thousands of women use them. Preliminary research suggests that online forums may promote help-seeking behavior, potentially because they have a role in challenging stigma...
February 20, 2017: JMIR Mental Health
https://www.readbyqxmd.com/read/28219587/management-of-bladder-cancer-after-renal-transplantation
#20
C Demirdag, S Citgez, Z Talat, B Onal
OBJECTIVES: In renal transplant recipients, the risk of developing bladder cancer and rate of diagnosis of advanced staged bladder cancer are generally higher than the general population. Also, it is more challenging to treat renal transplant recipients than the regular patient population. We aimed to evaluate the efficacy and safety of radical cystectomy (RC) and urinary diversion with ileal conduit in renal transplant recipients. METHODS: We identified 2 patients with prior history of renal transplantation who underwent RC and ileal conduit urinary diversion for bladder cancer...
March 2017: Transplantation Proceedings
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