keyword
https://read.qxmd.com/read/38428817/atlas-of-exercise-induced-brain-activation-in-mice
#21
JOURNAL ARTICLE
Grethe Skovbjerg, Andreas Mæchel Fritzen, Charlotte Sashi Air Svendsen, Johanna Perens, Jacob Lercke Skytte, Camilla Lund, Jens Lund, Martin Rønn Madsen, Urmas Roostalu, Jacob Hecksher-Sørensen, Christoffer Clemmensen
OBJECTIVES: There is significant interest in uncovering the mechanisms through which exercise enhances cognition, memory, and mood, and lowers the risk of neurodegenerative diseases. In this study, we utilize forced treadmill running and distance-matched voluntary wheel running, coupled with light sheet 3D brain imaging and c-FOS immunohistochemistry, to generate a comprehensive atlas of exercise-induced brain activation in mice. METHODS: To investigate the effects of exercise on brain activity, we compared whole-brain activation profiles of mice subjected to treadmill running with mice subjected to distance-matched wheel running...
February 28, 2024: Molecular Metabolism
https://read.qxmd.com/read/38414628/neurobiology-of-bruxism-the-impact-of-stress-review
#22
REVIEW
Ioannis A Pavlou, Demetrios A Spandidos, Vassilis Zoumpourlis, Veronica K Papakosta
Bruxism is a non-functional involuntary muscle activity that affects more than one-third of the population at some point in their lives. A number of factors have been found to be related to the etiopathogenesis of bruxism; therefore, the condition is considered multifactorial. The most commonly accepted factor is stress. Stress has long been considered to increase muscle tone and to reduce the pain threshold. Current evidence indicates that exposure to chronic stress, distress and allostatic load ignite neurological degeneration and the attenuation of critical neuronal pathways that are highly implicated in the orofacial involuntary muscle activity...
April 2024: Biomedical Reports
https://read.qxmd.com/read/38405686/investigating-the-impact-of-stress-on-pain-a-scoping-review-on-sense-of-control-social-evaluative-threat-unpredictability-and-novelty-stun-model
#23
REVIEW
Karen Ghoussoub, Catherine Isadora Côté, Maude Fortier, Bénédicte Nauche, Pierre Rainville, M Gabrielle Pagé
BACKGROUND: Stress can have paradoxical effects on pain, namely hyperalgesia and hypoalgesia. Four situational characteristics activate the hypothalamic-pituitary-adrenal axis, leading to a physiological stress response: lacking Sense of control, social-evaluative Threat, Unpredictability and Novelty (STUN). This scoping review reports on the types of evidence published on the effects of STUN characteristics on pain outcomes. DATABASES/DATA TREATMENT: Searches of primary electronic databases were performed to identify articles published on adults between 1990 and 2021 that contained search terms on pain and stress/STUN characteristics...
2024: Journal of Pain Research
https://read.qxmd.com/read/38399559/unraveling-the-complex-web-of-fibromyalgia-a-narrative-review
#24
REVIEW
Sarah Al Sharie, Scott J Varga, Lou'i Al-Husinat, Piercarlo Sarzi-Puttini, Mohammad Araydah, Batool Riyad Bal'awi, Giustino Varrassi
Fibromyalgia is a complex and often misunderstood chronic pain disorder. It is characterized by widespread musculoskeletal pain, fatigue, and heightened sensitivity, and has evolved in diagnostic criteria and understanding over the years. Initially met with skepticism, fibromyalgia is now recognized as a global health concern affecting millions of people, with a prevalence transcending demographic boundaries. The clinical features and diagnosis of fibromyalgia encompass a range of symptoms beyond pain, including sleep disturbances and cognitive difficulties...
February 4, 2024: Medicina
https://read.qxmd.com/read/38395315/role-of-soluble-epoxide-hydrolase-in-pain-and-depression-comorbidity
#25
JOURNAL ARTICLE
Yuchen Bu, Siqi Yang, Di Wang, Suwan Hu, Qi Zhang, Zifeng Wu, Chun Yang
The coexistence of chronic pain and depression in clinical practice places a substantial social burden and profoundly impacts in patients. Although a clear correlation exists, the underlying mechanism of comorbidity between chronic pain and depression remains elusive. Research conducted in recent decades has uncovered that soluble epoxide hydrolase, a pivotal enzyme in the metabolism of polyunsaturated fatty acids, plays a crucial role in inflammation. Interestingly, this enzyme is intricately linked to the development of both pain and depression...
February 21, 2024: Neurobiology of Disease
https://read.qxmd.com/read/38395015/mindfulness-induced-self-transcendence-promotes-universal-love-with-consequent-effects-on-opioid-misuse
#26
JOURNAL ARTICLE
Eric L Garland, Thupten Jinpa
In addition to its health benefits, mindfulness has been theorized in classical contemplative frameworks to elicit self-transcendent experiences as a means of promoting universal love and compassion. Increasing feelings of love may be especially clinically relevant for the treatment of opioid misuse, in that addictive use of opioids dysregulates neurobiological processes implicated in the experience of love. Here we tested these hypotheses in a secondary analysis (n = 187) of data from a randomized clinical trial of Mindfulness-Oriented Recovery Enhancement (MORE) versus supportive psychotherapy for comorbid opioid misuse and chronic pain...
February 7, 2024: Behaviour Research and Therapy
https://read.qxmd.com/read/38383920/neuron-microglia-interaction-is-involved-in-anti-inflammatory-response-by-vagus-nerve-stimulation-in-the-prefrontal-cortex-of-rats-injected-with-polyinosinic-polycytidylic-acid
#27
JOURNAL ARTICLE
Ki-Joong Kim, Jinyeon Hwang, Kang-Woo Lee, Jieun Kim, Yunha Han, Uk Namgung
Injection of polyinosinic:polycytidylic acid (poly(I:C)) into experimental animals induces neuroimmunological responses and thus has been used for the study of neurological disorders such as anxiety, depression, and chronic fatigue. Here, we investigated the effects of vagus nerve stimulation (VNS) on poly(I:C)-induced neuroinflammation and associated behavioral consequences in rats. The microglia in the prefrontal cortex (PFC) displayed the activated form of morphology in poly(I:C)-injected rats and changed to a normal shape after acute VNS (aVNS)...
February 22, 2024: Molecular Neurobiology
https://read.qxmd.com/read/38369488/lipopolysaccharide-ve-cadherin-hmgb1-and-hif-1%C3%AE-levels-are-elevated-in-the-systemic-circulation-in-chronic-migraine-patients-with-medication-overuse-headache-evidence-of-leaky-gut-and-inflammation
#28
JOURNAL ARTICLE
Doga Vuralli, Merve Ceren Akgor, Hale Gok Dagidir, Ozlem Gulbahar, Meltem Yalinay, Hayrunnisa Bolay
OBJECTIVE: Medication overuse headache (MOH) was recently shown to be associated with leaky gut in rodents. We aimed to investigate whether chronic migraine (CM) patients with MOH have elevated lipopolysaccharide levels and inflammatory molecules in blood circulation. MATERIALS AND METHODS: The study included women participants (40 CM patients with NSAID overuse headache, 35 episodic migraine (EM) patients, and 20 healthy non-headache sufferers). Migraine duration, monthly migraine headache days, MigSCog, HADS-D, HADS-A, and HIT-6 scores were recorded...
February 19, 2024: Journal of Headache and Pain
https://read.qxmd.com/read/38366580/topical-review-getting-into-the-head-of-youth-with-chronic-pain-how-theory-of-mind-deficits-may-relate-to-the-development-and-maintenance-of-pediatric-pain
#29
JOURNAL ARTICLE
Bridget A Nestor, Joe Kossowsky, Sarah M Nelson
OBJECTIVE: Theory of mind (ToM) is the ability to understand the thoughts, feelings, and mental states of others and is critical for effective social and psychological functioning. ToM deficits have been associated with various psychological disorders and identified in adult pain populations. For youth with chronic pain, ToM deficits may underlie the biological, psychological, and social factors that contribute to their experience of pain, but this remains poorly understood. METHODS: This topical review explored the extant literature in the areas of ToM and chronic pain, particularly for pediatric populations, with respect to biological, psychological, and social elements of the biopsychosocial model of pain...
February 15, 2024: Journal of Pediatric Psychology
https://read.qxmd.com/read/38363535/astrocyte-activation-in-the-acc-contributes-to-comorbid-anxiety-in-chronic-inflammatory-pain-and-involves-in-the-excitation-inhibition-imbalance
#30
JOURNAL ARTICLE
Naixuan Wei, Zi Guo, Mengting Qiu, Ru Ye, Xiaomei Shao, Yi Liang, Boyi Liu, Jianqiao Fang, Junfan Fang, Junying Du
Neurons within the anterior cingulate cortex (ACC) orchestrate the co-occurrence of chronic pain and anxiety. The ACC hyperactivity plays a crucial role in the emotional impact of neuropathic pain. Astrocyte-mediated neuroinflammatory is responsible for regulating the balance between excitation-inhibition (E/I) in the brain. However, there is limited understanding of the possible contributions of astrocytes in the ACC to comorbidity of anxiety and chronic inflammatory pain. This paper aims to investigate the possible contribution of astrocytes in the ACC to the comorbidity between anxiety and chronic inflammatory pain, as well as their involvement in the E/I imbalance of pyramidal cells...
February 16, 2024: Molecular Neurobiology
https://read.qxmd.com/read/38363424/expression-of-cgrp-in-the-trigeminal-ganglion-and-its-effect-on-the-polarization-of-macrophages-in-rats-with-temporomandibular-arthritis
#31
JOURNAL ARTICLE
Junli Tao, Xiaohui Wang, Jie Xu
Calcitonin gene-related peptide (CGRP) is synthesized and secreted by trigeminal ganglion neurons, and is a key neuropeptide involved in pain and immune regulation. This study investigates the expression of CGRP in the trigeminal ganglion (TG) and its regulatory role in the polarization of macrophages in rats with temporomandibular arthritis. A rat model of temporomandibular arthritis was established using CFA. Pain behavior was then observed. Temporomandibular joint (TMJ) and the TG were collected, and immunohistochemistry, immunofluorescence (IF) staining, and RT-qPCR were used to examine the expression of CGRP and macrophage-related factors...
February 16, 2024: Cellular and Molecular Neurobiology
https://read.qxmd.com/read/38348133/a-systematic-review-and-coordinate-based-meta-analysis-of-fmri-studies-on-acupuncture-at-lr-3
#32
Yawen Rao, Limin Ge, Jiaxin Wu
OBJECTIVES: The acupoint LR3 (Taichong) is frequently utilized in clinical acupuncture. However, its underlying neural mechanisms remain not fully elucidated, with speculations suggesting its close association with specific brain activity patterns. METHODS: A comprehensive literature search was undertaken across several online databases, such as PubMed, Web of Science, Embase, Cochrane Library, CNKI (China National Knowledge Infrastructure), Wanfang Database, VIP Database, and the Chinese Biomedical Database...
2024: Frontiers in Neuroscience
https://read.qxmd.com/read/38347700/neural-network-excitation-inhibition-a-key-to-empathy-and-empathy-impairment
#33
REVIEW
Yuanhong Tang, Chunjian Wang, Qingquan Li, Gang Liu, Da Song, Zhenzhen Quan, Yan Yan, Hong Qing
Empathy is an ability to fully understand and feel the mental states of others. We emphasize that empathy is elicited by the transmission of pain, fear, and sensory information. In clinical studies, impaired empathy has been observed in most psychiatric conditions. However, the precise impairment mechanism of the network systems on the pathogenesis of empathy impairment in psychiatric disorders is still unclear. Multiple lines of evidence suggest that disturbances in the excitatory/inhibitory balance in neurologic disorders are key to empathetic impairment in psychiatric disorders...
February 12, 2024: Neuroscientist: a Review Journal Bringing Neurobiology, Neurology and Psychiatry
https://read.qxmd.com/read/38341233/insight-gained-from-using-animal-models-to-study-pain-in-parkinson-s-disease
#34
JOURNAL ARTICLE
Yazead Buhidma, Joana Lama, Susan Duty
Pain is one of the key non-motor symptoms experienced by a large proportion of people living with Parkinson's disease (PD), yet the mechanisms behind this pain remain elusive and as such its treatment remains suboptimal. It is hoped that through the study of animal models of PD, we can start to unravel some of the contributory mechanisms, and perhaps identify models that prove useful as test beds for assessing the efficacy of potential new analgesics. However, just how far along this journey are we right now? Is it even possible to model pain in PD in animal models of the disease? And have we gathered any insight into pain mechanisms from the use of animal models of PD so far? In this chapter we intend to address these questions and in particular highlight the findings generated by others, and our own group, following studies in a range of rodent models of PD...
2024: International Review of Neurobiology
https://read.qxmd.com/read/38341227/setting-the-clinical-context-to-non-motor-symptoms-reflected-by-park-pain-park-sleep-and-park-autonomic-subtypes-of-parkinson-s-disease
#35
JOURNAL ARTICLE
Mubasher A Qamar, Phoebe Tall, Daniel van Wamelen, Yi Min Wan, Katarina Rukavina, Anna Fieldwalker, Donna Matthew, Valentina Leta, Kirsty Bannister, K Ray Chaudhuri
Non-motor symptoms (NMS) of Parkinson's disease (PD) are well described in both clinical practice and the literature, enabling their management and enhancing our understanding of PD. NMS can dominate the clinical pictures and NMS subtypes have recently been proposed, initially based on clinical observations, and later confirmed in data driven analyses of large datasets and in biomarker-based studies. In this chapter, we provide an update on what is known about three common subtypes of NMS in PD. The pain (Park-pain), sleep dysfunction (Park-sleep), and autonomic dysfunction (Park-autonomic), providing an overview of their individual classification, clinical manifestation, pathophysiology, diagnosis, and potential treatments...
2024: International Review of Neurobiology
https://read.qxmd.com/read/38336518/chronic-nicotine-exposure-elicits-pain-hypersensitivity-through-activation-of-dopaminergic-projections-to-anterior-cingulate-cortex
#36
JOURNAL ARTICLE
Danyang Chen, Liang Shen, Yu-Zhuo Zhang, Bu-Fan Kan, Qian-Qian Lou, Dan-Dan Long, Ji-Ye Huang, Zhi Zhang, Shan-Shan Hu, Di Wang
BACKGROUND: Cigarette smoking is commonly reported among chronic pain patients in the clinic. Although chronic nicotine exposure is directly linked to nociceptive hypersensitivity in rodents, underlying neurobiological mechanisms remain unknown. METHODS: Multi-tetrode recordings in freely moving mice were used to test the activity of dopaminergic projections from the ventral tegmental area (VTA) to pyramidal neurones in the anterior cingulate cortex (ACC) in chronic nicotine-treated mice...
February 8, 2024: British Journal of Anaesthesia
https://read.qxmd.com/read/38329679/electroacupuncture-alleviates-hyperalgesia-and-anxiety-like-behaviors-in-pain-memory-model-rats-through-activation-of-gabaergic-neurons-and-gaba-receptor-in-the-rostral-anterior-cingulate-cortex
#37
JOURNAL ARTICLE
Jing Sun, Chi Zhang, Yifang Wang, Siqi Xiao, Haiju Sun, Zhiyuan Bian, Zui Shen, Xiaofen He, Jianqiao Fang, Xiaomei Shao
Recent studies have confirmed that pain memory is often accompanied by negative emotions. Electroacupuncture (EA) can block the retrieval of painful memories, thereby alleviating the associated negative behaviors. However, the underlying mechanism is poorly understood. This study revealed that the effect of EA on pain memory-induced negative behaviors is related to the mediation of GABAergic neuron activity and GABA receptor expression in the rostral anterior cingulate cortex (rACC). Previous studies have shown that the rACC is a crucial area for regulating nociceptive behaviors and negative emotions in pain memory models...
February 8, 2024: Molecular Neurobiology
https://read.qxmd.com/read/38327725/pain-sensorimotor-interactions-new-perspectives-and-a-new-model
#38
REVIEW
Greg M Murray, Barry J Sessle
How pain and sensorimotor behavior interact has been the subject of research and debate for many decades. This article reviews theories bearing on pain-sensorimotor interactions and considers their strengths and limitations in the light of findings from experimental and clinical studies of pain-sensorimotor interactions in the spinal and craniofacial sensorimotor systems. A strength of recent theories is that they have incorporated concepts and features missing from earlier theories to account for the role of the sensory-discriminative, motivational-affective, and cognitive-evaluative dimensions of pain in pain-sensorimotor interactions...
2024: Neurobiology of Pain
https://read.qxmd.com/read/38314104/a-review-of-dorsal-root-ganglia-and-primary-sensory-neuron-plasticity-mediating-inflammatory-and-chronic-neuropathic-pain
#39
REVIEW
Kyeongran Jang, Sandra M Garraway
Pain is a sensory state resulting from complex integration of peripheral nociceptive inputs and central processing. Pain consists of adaptive pain that is acute and beneficial for healing and maladaptive pain that is often persistent and pathological. Pain is indeed heterogeneous, and can be expressed as nociceptive, inflammatory, or neuropathic in nature. Neuropathic pain is an example of maladaptive pain that occurs after spinal cord injury (SCI), which triggers a wide range of neural plasticity. The nociceptive processing that underlies pain hypersensitivity is well-studied in the spinal cord...
2024: Neurobiology of Pain
https://read.qxmd.com/read/38292321/inflammation-brain-connectivity-and-neuromodulation-in-post-traumatic-headache
#40
REVIEW
Fernando da Silva Fiorin, Caroline Cunha do Espírito Santo, Joyce T Da Silva, Man-Kyo Chung
Post-traumatic headache (PTH) is a debilitating condition that affects individuals with different levels of traumatic brain injury (TBI) severity. The difficulties in developing an effective treatment are related to a lack of understanding the complicated mechanisms and neurobiological changes in brain function after a brain injury. Preclinical studies have indicated that peripheral and central sensitization of the trigeminal nociceptive pathways contributes to PTH. While recent brain imaging studies have uncovered widespread changes in brain functional connectivity following trauma, understanding exactly how these networks contribute to PTH after injury remains unknown...
February 2024: Brain, behavior, & immunity health
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