Grethe Skovbjerg, Andreas Mæchel Fritzen, Charlotte Sashi Air Svendsen, Johanna Perens, Jacob Lercke Skytte, Camilla Lund, Jens Lund, Martin Rønn Madsen, Urmas Roostalu, Jacob Hecksher-Sørensen, Christoffer Clemmensen
OBJECTIVES: There is significant interest in uncovering the mechanisms through which exercise enhances cognition, memory, and mood, and lowers the risk of neurodegenerative diseases. In this study, we utilize forced treadmill running and distance-matched voluntary wheel running, coupled with light sheet 3D brain imaging and c-FOS immunohistochemistry, to generate a comprehensive atlas of exercise-induced brain activation in mice. METHODS: To investigate the effects of exercise on brain activity, we compared whole-brain activation profiles of mice subjected to treadmill running with mice subjected to distance-matched wheel running...
February 28, 2024: Molecular Metabolism