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pain neurobiology

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https://www.readbyqxmd.com/read/28725185/reticular-formation-and-pain-the-past-and-the-future
#1
REVIEW
Isabel Martins, Isaura Tavares
The involvement of the reticular formation (RF) in the transmission and modulation of nociceptive information has been extensively studied. The brainstem RF contains several areas which are targeted by spinal cord afferents conveying nociceptive input. The arrival of nociceptive input to the RF may trigger alert reactions which generate a protective/defense reaction to pain. RF neurons located at the medulla oblongata and targeted by ascending nociceptive information are also involved in the control of vital functions that can be affected by pain, namely cardiovascular control...
2017: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/28706741/the-link-between-depression-and-chronic-pain-neural-mechanisms-in-the-brain
#2
REVIEW
Jiyao Sheng, Shui Liu, Yicun Wang, Ranji Cui, Xuewen Zhang
Chronic pain, as a stress state, is one of the critical factors for determining depression, and their coexistence tends to further aggravate the severity of both disorders. Unfortunately, their association remains unclear, which creates a bottleneck problem for managing chronic pain-induced depression. In recent years, studies have found considerable overlaps between pain- and depression-induced neuroplasticity changes and neurobiological mechanism changes. Such overlaps are vital to facilitating the occurrence and development of chronic pain and chronic pain-induced depression...
2017: Neural Plasticity
https://www.readbyqxmd.com/read/28701703/the-behavioral-and-neural-basis-of-empathic-blame
#3
Indrajeet Patil, Marta Calò, Federico Fornasier, Fiery Cushman, Giorgia Silani
Mature moral judgments rely both on a perpetrator's intent to cause harm, and also on the actual harm caused-even when unintended. Much prior research asks how intent information is represented neurally, but little asks how even unintended harms influence judgment. We interrogate the psychological and neural basis of this process, focusing especially on the role of empathy for the victim of a harmful act. Using fMRI, we found that the 'empathy for pain' network was involved in encoding harmful outcomes and integrating harmfulness information for different types of moral judgments, and individual differences in the extent to which this network was active during encoding and integration of harmfulness information determined severity of moral judgments...
July 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28699403/rna-seq-investigations-of-human-post-mortem-trigeminal-ganglia
#4
Danielle M LaPaglia, Matthew R Sapio, Peter D Burbelo, Jean Thierry-Mieg, Danielle Thierry-Mieg, Stephen J Raithel, Christopher E Ramsden, Michael J Iadarola, Andrew J Mannes
Background The trigeminal ganglion contains neurons that relay sensations of pain, touch, pressure, and many other somatosensory modalities to the central nervous system. The ganglion is also a reservoir for latent herpes virus 1 infection. To gain a better understanding of molecular factors contributing to migraine and headache, transcriptome analyses were performed on postmortem human trigeminal ganglia. Methods RNA-Seq measurements of gene expression were conducted on small sub-regions of 16 human trigeminal ganglia...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/28694679/a-clinical-perspective-on-a-pain-neuroscience-education-approach-to-manual-therapy
#5
Adriaan Louw, Jo Nijs, Emilio J Puentedura
In recent years, there has been an increased interest in pain neuroscience education (PNE) in physical therapy. There is growing evidence for the efficacy of PNE to decrease pain, disability, fear-avoidance, pain catastrophization, limited movement, and health care utilization in people struggling with pain. PNE teaches people in pain more about the biology and physiology of their pain experience including processes such as central sensitization, peripheral sensitization, allodynia, inhibition, facilitation, neuroplasticity and more...
July 2017: Journal of Manual & Manipulative Therapy
https://www.readbyqxmd.com/read/28690582/decreased-openness-to-experience-is-associated-with-migraine-type-headaches-in-subjects-with-lifetime-depression
#6
Mate Magyar, Xenia Gonda, Dorottya Pap, Andrea Edes, Attila Galambos, Daniel Baksa, Natalia Kocsel, Edina Szabo, Gyorgy Bagdy, Rebecca Elliott, Gyongyi Kokonyei, Gabriella Juhasz
INTRODUCTION: Migraine and depression frequently occur as comorbid conditions, and it has been hypothesized that migraine with and without depression may have a different genetic background. A distinct personality trait constellation has been described in migraineurs. Less attention, however, was paid to personality differences in migraineurs with and without depression which may also shed light on differences in the neurobiological, background. The aim of our study was to investigate big five personality traits, headaches, and lifetime depression (DEP) in a large European general population sample...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28666966/aapt-diagnostic-criteria-for-central-neuropathic-pain
#7
Eva Widerström-Noga, John D Loeser, Troels Staehelin Jensen, Nanna Brix Finnerup
Central neuropathic pain, which is pain caused by a lesion or disease of the central somatosensory nervous system, is a serious consequence of spinal cord injury, stroke, multiple sclerosis, and other conditions affecting the central nervous system. A collaborative effort between the Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks public-private partnership and the American Pain Society, the Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks-American Pain Society Pain Taxonomy (AAPT) initiative, invited a working group to develop diagnostic criteria for central neuropathic pain...
June 27, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28664196/postinflammatory-hyperpigmentation-after-human-cold-pain-testing
#8
Melissa J Wolz, Katelyn E Sadler, Caela C Long, Daniel S Brenner, Brian S Kim, Robert W Gereau, Benedict J Kolber
Changes in cold temperature sensitivity are often associated with chronic pain conditions. Progress in understanding the neurobiological mechanism underlying these changes and resulting development of effective therapies has been slowed by the accessibility and affordability of devices used to measure thermal sensitivity in humans. To address this gap, we developed an inexpensive method to measure cold pain thresholds in healthy adult volunteers using dry ice and a thermode. However, early in preliminary testing, a subject presented with epidermal postinflammatory hyperpigmentation that lasted for >200 days...
August 2016: Pain Reports (Baltimore, Md.)
https://www.readbyqxmd.com/read/28651098/an-interoceptive-model-of-bulimia-nervosa-a-neurobiological-systematic-review
#9
REVIEW
Megan Klabunde, Danielle Collado, Cara Bohon
The objective of our study was to examine the neurobiological support for an interoceptive sensory processing model of bulimia nervosa (BN). To do so, we conducted a systematic review of interoceptive sensory processing in BN, using the PRISMA guidelines. We searched PsychInfo, Pubmed, and Web of Knowledge databases to identify biological and behavioral studies that examine interoceptive detection in BN. After screening 390 articles for inclusion and conducting a quality assessment of articles that met inclusion criteria, we reviewed 41 articles...
June 19, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28616655/-cognitive-perceptive-approaches-in-the-treatment-of-chronic-pain
#10
REVIEW
C Storz, H Schulte-Göcking, M Azqueta, C Wania, M Neugebauer, A Reiners, S Azad, E Kraft
In the treatment of difficult chronic pain conditions, cognitive-perceptive approaches offer an alternative to conventional therapies. Especially phantom limb pain and complex regional pain syndrome (CRPS) are frequently treated with these promising modalities. This article provides an overview of the most important cognitive-perceptive therapies and the research results concerning their clinical efficacy. In addition, we discuss their neurobiological foundation and clinical perspectives.
June 14, 2017: Der Schmerz
https://www.readbyqxmd.com/read/28602044/the-dynamic-interaction-between-pain-and-opioid-misuse
#11
REVIEW
Adrianne R Wilson-Poe, Jose A Morón
In 2014, drug overdose surpassed automobile accidents as the number one cause of accidental death for the first time in the history of the United States. The overdose epidemic is largely driven by opioids, and genuine prescription opioid analgesics play the biggest role in this phenomenon. Despite advancements in abuse deterrent formulations, prescription drug monitoring programmes and clinical assessments for the detection of abuse potential, drug overdoses continue to escalate. The Center for Disease Control has recently issued new guidelines for opioid prescription, yet even these recommendations have their shortcomings...
June 11, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28596533/breaking-barriers-to-novel-analgesic-drug-development
#12
REVIEW
Ajay S Yekkirala, David P Roberson, Bruce P Bean, Clifford J Woolf
Acute and chronic pain complaints, although common, are generally poorly served by existing therapies. This unmet clinical need reflects a failure to develop novel classes of analgesics with superior efficacy, diminished adverse effects and a lower abuse liability than those currently available. Reasons for this include the heterogeneity of clinical pain conditions, the complexity and diversity of underlying pathophysiological mechanisms, and the unreliability of some preclinical pain models. However, recent advances in our understanding of the neurobiology of pain are beginning to offer opportunities for developing novel therapeutic strategies and revisiting existing targets, including modulating ion channels, enzymes and G-protein-coupled receptors...
June 9, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28595945/role-of-placebo-effects-in-pain-and-neuropsychiatric-disorders
#13
REVIEW
Annabelle M Belcher, Sergi Ferré, Pedro E Martinez, Luana Colloca
The placebo (and the nocebo) effect is a powerful determinant of health outcomes in clinical disease treatment and management. Efforts to completely eradicate placebo effects have shifted dynamically, as increasingly more researchers are tuned to the potentially beneficial effects of incorporating those uncontrollable placebo effects into clinical therapeutic strategies. In this review, we highlight the major findings from placebo research, elucidating the main neurobiological systems and candidate determinants of the placebo phenomenon, and illustrate a perspective that can effectively frame future research on the topic...
June 8, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28586443/deconstructing-one-medical-school-s-pain-curriculum-ii-partnering-with-medical-students-on-an-evidence-guided-redesign
#14
Ylisabyth S Bradshaw, Neha Patel Wacks, Alejandra Perez-Tamayo, Brenden Myers, Chukwueloka Obionwu, Rebecca A Lee, Daniel B Carr
Objective: To reshape medical education about pain to present it as a population-based public health process as well as a neuron-centered phenomenon. Design: Collaborate with students to apply a recent inventory of pain-related preclinical curricular content and clinical training in order to modify the current multiyear presentation and offer a broadened social perspective on pain. Appraise fourth-year medical students' pain-related educational needs by surveying their knowledge, attitudes, experience with the curriculum, and self-reported assessment of pain-related competencies...
April 1, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28579944/impaired-spinal-glucocorticoid-receptor-signaling-contributes-to-the-attenuating-effect-of-depression-on-mechanical-allodynia-and-thermal-hyperalgesia-in-rats-with-neuropathic-pain
#15
Xiao Wei, Yuqi Sun, Fei Luo
Although depression-induced altered pain perception has been described in several laboratory and clinical studies, its neurobiological mechanism in the central nervous system (CNS), particularly in the spinal dorsal horn, remains unclear. Therefore, in this study, we aimed to clarify whether nociceptive sensitivity of neuropathic pain is altered in the olfactory bulbectomy (OB) model of depression and whether glucocorticoid receptor (GR), which is involved in the etio-pathologic mechanisms of both major depression and neuropathic pain, contributes to these processes in the spinal dorsal horn of male Sprague-Dawley rats...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28569221/a-four-part-working-bibliography-of-neuroethics-part-4-ethical-issues-in-clinical-and-social-applications-of-neuroscience
#16
EDITORIAL
Kira Becker, John R Shook, Martina Darragh, James Giordano
BACKGROUND: As a discipline, neuroethics addresses a range of questions and issues generated by basic neuroscientific research (inclusive of studies of putative neurobiological processes involved in moral and ethical cognition and behavior), and its use and meanings in the clinical and social spheres. Here, we present Part 4 of a four-part bibliography of the neuroethics literature focusing on clinical and social applications of neuroscience, to include: the treatment-enhancement discourse; issues arising in neurology, psychiatry, and pain care; neuroethics education and training; neuroethics and the law; neuroethics and policy and political issues; international neuroethics; and discourses addressing "trans-" and "post-" humanity...
May 31, 2017: Philosophy, Ethics, and Humanities in Medicine: PEHM
https://www.readbyqxmd.com/read/28557681/hypnosis-in-cancer-care
#17
Joshua Wortzel, David Spiegel
Cancer affects a growing proportion of the population as survival improves. The illness and its treatment brings a substantial burden of symptoms, including pain, anxiety, insomnia, and grief. Here, the uses of hypnosis in the treatment of these cancer-related problems will be reviewed. The utility of measuring hypnotizability in the clinical setting will be discussed. The current neurobiology of hypnotizability and hypnosis will be reviewed. Methods and results of using hypnosis for pain control in acute and chronic settings will be presented...
July 2017: American Journal of Clinical Hypnosis
https://www.readbyqxmd.com/read/28537555/identification-of-a-novel-spinal-nociceptive-motor-gate-control-for-a%C3%AE-pain-stimuli-in-rats
#18
Dvir Blivis, Gal Haspel, Philip Z Mannes, Michael J O'Donovan, Michael J Iadarola
Physiological responses to nociceptive stimuli are initiated within tens of milliseconds, but the corresponding sub-second behavioral responses have not been adequately explored in awake, unrestrained animals. A detailed understanding of these responses is crucial for progress in pain neurobiology. Here, high-speed videography during nociceptive Aδ fiber stimulation demonstrated engagement of a multi-segmental motor program coincident with, or even preceding, withdrawal of the stimulated paw. The motor program included early head orientation and adjustments of the torso and un-stimulated paws...
May 24, 2017: ELife
https://www.readbyqxmd.com/read/28503039/the-possible-role-of-meditation-in-myofascial-pain-syndrome-a-new-hypothesis
#19
Prashanth Panta
BACKGROUND OF HYPOTHESIS: Myofascial pain syndrome (MPS) is the most common musculoskeletal pain disorder of the head and neck area. In the past, several theories were put forth to explain its origin and nature, but none proved complete. Myofascial pain responds to changing psychological states and stress, anxiety, lack of sleep, anger, depression and chronic pain are direct contributional factors. Myofascial pain syndrome may be considered as a psychosomatic disorder. There are numerous accepted palliative approaches, but of all, relaxation techniques stand out and initiate healing at the base level...
April 2017: Indian Journal of Palliative Care
https://www.readbyqxmd.com/read/28493519/neurotransmitters-behind-pain-relief-with-transcranial-magnetic-stimulation-positron-emission-tomography-evidence-for-release-of-endogenous-opioids
#20
S Lamusuo, J Hirvonen, P Lindholm, I K Martikainen, N Hagelberg, R Parkkola, T Taiminen, J Hietala, S Helin, A Virtanen, A Pertovaara, S K Jääskeläinen
BACKGROUND: Repetitive transcranial magnetic stimulation (rTMS) at M1/S1 cortex has been shown to alleviate neuropathic pain. OBJECTIVES: To investigate the possible neurobiological correlates of cortical neurostimulation for the pain relief. METHODS: We studied the effects of M1/S1 rTMS on nociception, brain dopamine D2 and μ-opioid receptors using a randomized, sham-controlled, double-blinded crossover study design and 3D-positron emission tomography (PET)...
May 11, 2017: European Journal of Pain: EJP
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